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https://www.readbyqxmd.com/read/29232486/an-essential-warning-editorial-on-vertebral-fractures-after-discontinuation-of-denosumab-a-post-hoc-analysis-of-the-randomized-placebo-controlled-freedom-trial-its-extension
#1
Benjamin Leder
Over the past two decades, osteoporosis treatment options have expanded greatly and physicians and patients are now able to choose among several classes of medications and numerous specific drugs. As these options have grown, however, the choice of which medication to prescribe and how to balance the risks and benefits in specific populations and individual patients has become increasingly complex. This complexity, in turn, combined with the proliferation of well-publicized reports of rare but serious side effects, is exacerbating the recent trend of declining rates of osteoporosis treatment...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29232319/knowledge-of-the-warning-signs-of-foot-ulcer-deterioration-among-patients-with-diabetes
#2
Yen-Fan Chin, Jiun-Ting Yeh, Hsing-Yi Yu, Li-Chueh Weng
BACKGROUND: Seeking treatment in a timely manner may prevent lower limb amputation subsequent to diabetic foot ulcers. Knowledge regarding the warning signs is one important factor that is related to the timely treatment seeking of patients with diabetic foot ulcers. However, there is no previous research on which aspects of such knowledge that patients with diabetes are lacking. PURPOSE: The aims of this study were to test the psychometric properties of a questionnaire that was designed to assess the knowledge of the warning signs of diabetic foot ulcer deterioration and to determine the knowledge of these warning signs among patients with a history of diabetic foot ulcers...
December 7, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29232258/development-and-history-of-morcellators
#3
Ceana Nezhat, Robert K Zurawin
PURPOSE OF REVIEW: Controversy exists surrounding extraction of tissue in gynecologic surgery using morcellators following cases of disseminated uterine cancers discovered after the use of electromechanical morcellators. This chapter traces the history of tissue extraction in gynecology and reviews the evolving scientific data and opinions regarding the future of morcellation. RECENT FINDINGS: Since the initial Food and Drug Administration warning about morcellation in 2014, subsequent studies do not support the Food and Drug Administration's high incidence of occult uterine cancer...
December 11, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29230686/impact-of-a-breast-cancer-educational-program-on-female-university-students-knowledge-attitudes-and-practices
#4
Arwa Alsaraireh, Muhammad W Darawad
Breast cancer (BC) is a worldwide fatal cancer among females. Efforts fighting against this disease should start with females at younger ages. This study evaluated the effectiveness a BC educational program in promoting female university students' knowledge and attitudes towards BC and practices of breast self-examination (BSE). A pre- and post-test design was used in two phases; pre- and post-intervention phase. A 1-day educational program was conducted with theoretical and practical educational sessions. Participants were evaluated twice (before and 2 weeks after the intervention) for the following variables: knowledge regarding BC warning signs, BC risk factors and knowledge in regard to BSE, in addition to their attitudes and practices of BSE...
December 11, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29229971/development-of-decision-forest-models-for-prediction-of-drug-induced-liver-injury-in-humans-using-a-large-set-of-fda-approved-drugs
#5
Huixiao Hong, Shraddha Thakkar, Minjun Chen, Weida Tong
Drug-induced liver injury (DILI) presents a significant challenge to drug development and regulatory science. The FDA's Liver Toxicity Knowledge Base (LTKB) evaluated >1000 drugs for their likelihood of causing DILI in humans, of which >700 drugs were classified into three categories (most-DILI, less-DILI, and no-DILI). Based on this dataset, we developed and compared 2-class and 3-class DILI prediction models using the machine learning algorithm of Decision Forest (DF) with Mold2 structural descriptors...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229436/a-longitudinal-analysis-of-allostatic-load-among-a-multi-ethnic-sample-of-midlife-women-findings-from-the-study-of-women-s-health-across-the-nation
#6
Laura Chyu, Dawn M Upchurch
OBJECTIVES: We examined longitudinal patterns and sociodemographic correlates of allostatic load (AL), a measure of cumulative biological risk and aging, in a sample of midlife women consisting of non-Hispanic White, African American, Chinese, and Japanese women. METHODS: Longitudinal cohort data from the Study of Women's Health Across the Nation were used to examine AL patterns in midlife women ages 42-53 (n = 1,932). AL measures were created using 10 biomarkers representing cardiovascular, inflammatory, neuroendocrine, and metabolic system functioning...
December 8, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29227462/psychiatric-disorders-antiretroviral-medication-adherence-and-viremia-in-a-cohort-of-perinatally-hiv-infected-adolescents-and-young-adults
#7
Amelia Bucek, Cheng-Shiun Leu, Stephanie Benson, Patricia Warne, Elaine J Abrams, Katherine S Elkington, Curtis Dolezal, Andrew Wiznia, Claude Ann Mellins
BACKGROUND: Perinatally HIV-infected (PHIV+) adolescents and young adults (AYA) are at risk for sub-optimal antiretroviral therapy (ART) adherence, and mental health and substance use problems that, in HIV-infected adults, predict non-adherence. Studies on the relationship between psychiatric and substance use disorders (SUD) and adherence among PHIV+ AYA are limited, but may be important to informing evidence-based interventions to promote adherence. METHODS: Data were analyzed from three annual follow-up interviews (FU2-4, N=179) in a longitudinal study of PHIV+ AYA...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227303/alternative-facts-and-morcellation
#8
David L Olive
PURPOSE OF REVIEW: Since the recent black-box warning regarding the use of electromechanical morcellation, there has been a hesitancy to utilize the product and even to perform other types of morcellation by gynecologists. Unfortunately, this Food and Drug Administration action and the continued public criticisms of this procedure are grounded in poor data and faulty reasoning. To truly perform informed consent to patients considering procedures involving morcellation, a thorough review of the facts, not alternative facts, must be communicated...
December 8, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29225757/dengue-fever-in-a-south-asian-metropolis-a-report-on-219-cases
#9
Shiv Sekhar Chatterjee, Ankush Sharma, Shilpee Choudhury, Sushil Kumar Chumber, Ras Bage, Nittin Parkhe, Uma Khanduri
Background and Objectives: Yearly epidemics of Dengue fever occur post-monsoon in India's capital, Delhi. A prospective observational study was conducted during the outbreak months to understand the epidemiology and outcome of this infection and its economic impact. Materials and Methods: Febrile hospitalized (n=219) patients with dengue fever diagnosed by a combination of MAC-ELISA, GAC-ELISA and NS1Antigen-ELISA were enrolled. Epidemiologic (including economic) parameters, clinical, radiological and laboratory manifestations were noted and patients followed up over the period of hospital stay...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29224980/factors-responsible-for-the-post-slaughter-loss-of-carcass-and-offal-s-in-abattoirs-in-south-africa
#10
Ishmael Festus Jaja, Borden Mushonga, Ezekiel Green, Voster Muchenje
Global demand for food is surging upward due to the expansion of human population. Hence food production and supply need to double with little or no waste to meet this demand. Food loss at any point in the farm to fork chain inhibits the stability of food security at household and national level. A retrospective (AR) and a post mortem meat inspection (PMMI) study to identify major causes of offal and carcass condemnation was conducted in three abattoirs namely, Adeliade, Queenstown and East London abattoirs represented as AD, QT, and EL respectively...
December 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29224770/pain-control-following-tonsillectomy-in-children-a-survey-of-patients
#11
Philip R Persino, Lena Saleh, David L Walner
OBJECTIVE: This prospective study aimed to survey pediatric patients and their parents after tonsillectomy to assess their pain management utilization and satisfaction. INTRODUCTION: Tonsillectomy is the second most common surgical procedure performed in pediatric patients. Postoperative recovery is often associated with high levels of pain and severe functional limitations. There is currently no consensus on pain control regimens. Additionally, a recent FDA Black Box Warning on narcotic use has caused more uncertainty in appropriate pain control regimens...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223710/behavioral-responses-of-cd-1-mice-to-conspecific-and-heterospecific-blood-odors-and-to-a-blood-odor-component
#12
Christian Lahger, Matthias Laska
The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species we assessed behavioral responses of male CD-1 mice (n=60) to the odor of blood of same-sex and opposite-sex conspecifics, of a natural predator of mice (cat), and of a herbivore (horse) and an omnivore (human) non-predator of mice. Further, we assessed their behavior towards the mammalian blood odor component trans-4,5-epoxy-(E)-2-decenal which recent studies have shown to be as attractive to mammalian predators as the odor of real blood...
December 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29223440/outcomes-of-cardiac-pacing-in-adult-patients-after-a-fontan-operation
#13
Alexander C Egbe, Geoffery D Huntley, Heidi M Connolly, Naser M Ammash, Abhishek J Deshmukh, Arooj R Khan, Sameh M Said, Emmanuel Akintoye, Carole A Warnes, Suraj Kapa
BACKGROUND: Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS: We performed a retrospective review of Fontan patients from 1994 through 2014. We defined DRCs as lead failure, lead recall, cardiac perforation, lead thrombus/vegetation, or device-related infection, and cardiovascular adverse events (CAEs) as venous thrombosis, stroke, death, or heart transplant...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29223168/serious-gastric-perforation-after-second-stereotactic-body-radiotherapy-for-peripheral-lung-cancer-that-recurred-after-initial-stereotactic-body-radiotherapy-a-case-report
#14
Hotaka Nonaka, Hiroshi Onishi, Masatoki Ozaki, Kengo Kuriyama, Takafumi Komiyama, Ryo Saito
BACKGROUND: In recent reports, re-irradiation with stereotactic body radiotherapy for lung tumors in patients previously treated with thoracic radiation therapy resulted in several serious toxicities. Serious non-lung toxicities were observed mostly in patients with central tumors, but we experienced a case of fatal gastric perforation after a second stereotactic body radiotherapy in a patient with a peripheral lung tumor. CASE PRESENTATION: An 83-year-old Asian man was diagnosed with T2N0M0 lung cancer in the form of squamous cell carcinoma in the lower lobe of his left lung...
December 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29222108/illicit-cigarette-sales-in-indian-cities-findings-from-a-retail-survey
#15
Rijo M John, Hana Ross
OBJECTIVE: To estimate illicit cigarette consumption in India using a modified and replicable method and compare it with estimates generated by the tobacco industry and by a commercial entity. METHODS: The study employed a modified approach to cigarette pack analysis suitable for countries with prevalent single-cigarette sales. Empty cigarette packs generated by 1 day's single-cigarette sales were collected directly from cigarette vendors in four large and four small cities covering the length and breadth of India...
December 8, 2017: Tobacco Control
https://www.readbyqxmd.com/read/29221787/evaluation-of-alternative-serum-biomarkers-to-monitor-the-progression-of-chronic-hbv-and-hcv-infection
#16
S Tsiomita, U Georgopoulou, P P Doumba, J Koskinas, K Adamidis, C Papaloukas, G Thyphronitis
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are among the most serious health conditions affecting about 600 million people worldwide leading to a number of severe liver diseases. Due to the lack of warning signs or mild symptoms during the early stage of the infection, a molecular signature associated with disease progression would be useful. Based on our recent paper where candidate biomarkers were determined through topological and modularity analysis of protein interaction networks (PINs), this study was focused on the evaluation of MIF, TNFRSF1A, FAS and TMSB4X as diagnostic biomarkers in chronic HBV and HCV infections...
December 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29220520/gaps-in-workplace-education-for-prevention-of-occupational-skin-disease
#17
Tanya Gupta, Victoria H Arrandale, Irena Kudla, D Linn Holness
Background: Occupational contact dermatitis (OCD) is a common occupational disease. Evidence suggests that education and training are effective prevention strategies. In spite of these known prevention strategies, workers continue to develop OCD. Little is reported regarding the actual training experience of workers. Objective: To examine the training experience of workers with contact dermatitis to identify areas for improvement. Methods: Participants were workers being assessed for contact dermatitis in an occupational health clinic...
December 5, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29220115/hiv-prevention-where-it-is-needed-most-comparison-of-strategies-for-the-geographical-allocation-of-interventions
#18
Sarah-Jane Anderson, Peter D Ghys, Regina Ombam, Timothy B Hallett
INTRODUCTION: A strategic approach to the application of HIV prevention interventions is a core component of the UNAIDS Fast Track strategy to end the HIV epidemic by 2030. Central to these plans is a focus on high-prevalence geographies, in a bid to target resources to those in greatest need and maximize the reduction in new infections. Whilst this idea of geographical prioritization has the potential to improve efficiency, it is unclear how it should be implemented in practice. There are a range of prevention interventions which can be applied differentially across risk groups and locations, making allocation decisions complex...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29219284/does-a-previous-prostate-biopsy-related-acute-bacterial-prostatitis-affect-the-results-of-radical-prostatectomy
#19
Hakan Türk, Sitki Ün, Erkan Arslan, Ferruh Zorlu
OBJECTIVE: To The standard technique for obtaining a histologic diagnosis of prostatic carcinomas is transrectal ultrasound guided prostate biopsy. Acute prostatitis which might develop after prostate biopsy can cause periprostatic inflammation and fibrosis. In this study, we performed a retrospective review of our database to determine whether ABP history might affect the outcome of RP. MATERIALS AND METHODS: 441 RP patients who were operated in our clinic from 2002 to 2014 were included in our study group...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29218211/a-rare-anatomical-variant-transosseous-supraclavicular-nerve-identified-during-clavicle-fracture-fixation
#20
Jasdeep Giddie, Rachel Fisher, Andrew White
We describe a rare case of an anatomical variant of the supraclavicular nerve in the intra-operative setting of clavicle fixation for a fracture. Intra-operatively it was noted that one of the supraclavicular nerves was passing through a foramen in the clavicle shaft. A 60-year-old gentleman presented with a displaced multifragmentary fracture of the left clavicle after a fall. Plate fixation with a pre-contoured locking plate was performed under general anaesthesia. The clavicle was exposed through an infraclavicular transverse incision...
November 2017: Journal of Surgical Case Reports
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