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https://www.readbyqxmd.com/read/28626539/resistance-to-colistin-in-klebsiella-pneumoniae-a-4-0-strain
#1
REVIEW
Guido Granata, Nicola Petrosillo
The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed. Treatment options for multidrug-resistant K. pneumoniae are actually limited to combination therapy with some aminoglycosides, tigecycline and to older antimicrobial agents. Unfortunately, the prevalence of colistin-resistant and tigecycline-resistant K...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28614982/intraventricular-administration-of-tigecycline-for-the-treatment-of-multidrug-resistant-bacterial-meningitis-after-craniotomy-a-case-report
#2
Yuanxing Wu, Kai Chen, Jingwei Zhao, Qiang Wang, Jianxin Zhou
BACKGROUND: Intracranial infections, especially multidrug-resistant (MDR) bacterial meningitis, are one of the most severe complications after craniotomy and may greatly impact patient outcomes. CASE PRESENTATION: We report a case of severe MDR Klebsiella pneumonia meningitis after craniotomy that was treated with three different dosages of tigecycline (Pfizer, New York, NY, U.S.A.)via a combined intravenous (IV) and intracerebroventricular (ICV) administration...
June 14, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28614259/global-regulator-soxr-is-a-negative-regulator-of-efflux-pump-gene-expression-and-affects-antibiotic-resistance-and-fitness-in-acinetobacter-baumannii
#3
Henan Li, Qi Wang, Ruobing Wang, Yawei Zhang, Xiaojuan Wang, Hui Wang
SoxR is a global regulator contributing to multidrug resistance in Enterobacteriaceae. However, the contribution of SoxR to antibiotic resistance and fitness in Acinetobacter baumannii has not yet been studied. Comparisons of molecular characteristics were performed between 32 multidrug-resistant A. baumannii isolates and 11 susceptible isolates. A soxR overexpression mutant was constructed, and its resistance phenotype was analyzed. The impact of SoxR on efflux pump gene expression was measured at the transcription level...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28612536/-resistance-of-acinetobacter-baumannii-to-tigecycline
#4
Jun-Yan Qu, Xiao-Ju Ü
OBJECTIVES: To determine the impact of long-term use of antibiotics and ultraviolet radiation on the resistance of Acinetobacter baumannii to tigecycline and the viability of tigecycline-resistant Acinetobacter baumannii . METHODS: Three strains of tigecycline sensitive Acinetobacter baumannii were selected. Tigecycline resistance was induced through multi-step method or by ultraviolet radiation. Two strains of tigecycline resistant Acinetobacter baumannii were repeatedly passaged on blank MHA plates, for the purpose of determination of minimum inhibitory concentrations (MICs) of tigecycline using broth microdilution method...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28607024/population-pharmacokinetics-of-tigecycline-in-critically-ill-patients-with-severe-infections
#5
Jiao Xie, Jason A Roberts, Abdulaziz S Alobaid, Claire Roger, Yan Wang, Qianting Yang, Jinyao Sun, Haiyan Dong, Xue Wang, Jianfeng Xing, Jeffrey Lipman, Yalin Dong
Objectives: We sought to describe the population pharmacokinetics of tigecycline in critically ill patients and describe optimized dosing regimens of tigecycline for different bacterial infections.Methods: This prospective study included ten critically ill patients given a standard dose of tigecycline. Blood samples were collected during one dosing interval and analyzed using validated chromatography. Population pharmacokinetics and Monte Carlo dosing simulations were undertaken using Pmetrics. Three target exposures, ratios of 24h area under the curve to minimum inhibitory concentrations (AUC0-24/MIC), were evaluated (≥17...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28602387/surveillance-of-carbapenemase-producing-enterobacteriaceae%C3%A2-in-the-indian-ocean-region-between-january-2010%C3%A2-and-december-2015
#6
A M Holman, J Allyn, G Miltgen, N Lugagne, N Traversier, S Picot, A Lignereux, C Oudin, O Belmonte, N Allou
BACKGROUND: The aim of this study was to trace the emergence of carbapenemase-producing Enterobacteriaceae (CPE) on Reunion Island, a French overseas territory well suited for the surveillance of CPE emergence in patients from the entire Indian Ocean Region. METHODS: This retrospective multicenter study was conducted on Reunion Island between 2010 and 2015. RESULTS: A total of 43 CPEs were isolated during the course of the study, in 36 patients (50% in the last year alone)...
June 8, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28602098/antibacterial-constituents-from-antarctic-fungus-aspergillus-sydowii-sp-1
#7
Wen-Ting Li, Dan Luo, Jia-Ning Huang, Lin-Lin Wang, Feng-Guo Zhang, Tao Xi, Jian-Min Liao, Yuan-Yuan Lu
One new alkaloid, named as acremolin C (1), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo-(L-Trp-L-Phe) (2), 4-hydroxyphenylacetic acid (3), (7S)-(+)-hydroxysydonic acid (4) and (7S, 11S)-(+)-12-hydroxysydonic acid (5), were isolated and identified. Biological studies disclosed that compounds 2, 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE...
June 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28600216/molecular-epidemiology-and-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus-circulating-in-the-russian-federation
#8
Vladimir Gostev, Alexander Kruglov, Olga Kalinogorskaya, Olga Dmitrenko, Olga Khokhlova, Tatsuo Yamamoto, Yuri Lobzin, Irina Ryabchenko, Sergey Sidorenko
The aim of this study was to investigate the patterns of antimicrobial resistance and molecular features of methicillin-resistant Staphylococcus aureus (MRSA) isolates in Russia. Isolates recovered from hospital patients (n=480), healthy medical personnel (n=25), and healthy carriers (n=13) were included in the study. Hospital-acquired MRSA (HA-MRSA) demonstrated high resistance to ciprofloxacin, gentamicin, and chloramphenicol (76%-92%), moderate - to tetracycline, erythromycin, clindamycin, and rifampicin (38%-54%), and low - to fusidic acid, co-trimoxazole, mupirocin, and daptomycin (2%-7%)...
June 7, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28584435/a-study-of-24-patients-with-colistin-resistant-gram-negative-isolates-in-a-tertiary-care-hospital-in-south-india
#9
Rajalakshmi Arjun, Ram Gopalakrishnan, P Senthur Nambi, D Suresh Kumar, R Madhumitha, V Ramasubramanian
BACKGROUND: As the use of colistin to treat carbapenem-resistant Gram-negative infections increases, colistin resistance is being increasingly reported in Indian hospitals. MATERIALS AND METHODS: Retrospective chart review of clinical data from patients with colistin-resistant isolates (minimum inhibitory concentration >2 mcg/ml). Clinical profile, outcome, and antibiotics that were used for treatment were analyzed. RESULTS: Twenty-four colistin-resistant isolates were reported over 18 months (January 2014-June 2015)...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28578555/infections-due-to-acinetobacter-baumannii-in-the-icu-treatment-options
#10
Joseph P Lynch, George G Zhanel, Nina M Clark
Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and infections of the bloodstream, urinary tract, and wounds). Treatment of Acinetobacter infections is difficult, as Acinetobacter spp. are intrinsically resistant to multiple antimicrobial agents, and have a remarkable ability to acquire new resistance determinants via mechanisms that include plasmids, transposons, integrons, and resistance islands...
June 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28572073/tigecycline-treatment-in-an-infant-with-extensively-drug-resistant-acinetobacter-baumannii-bacteremia
#11
Jiawei Zeng, Lidan Zhang, Min Gao, Jingjing Wu, Haiyan Wu, Jie Chen, Xiao Chen, Wen Tang
The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented. Tigecycline serum concentrations were monitored to help improve antibiotic efficacy and minimize side effects. A literature review identified 11 additional pediatric cases of A. baumannii infection treated with tigecycline since 2011. Tigecycline treatment should be considered in children with extensively drug-resistant bacterial infections.
May 29, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28572036/draft-genome-sequence-of-a-multidrug-resistant-oxa-23-producing-acinetobacter-baumannii-st191-clinical-isolate-from-china
#12
Juan Xu, Wenping Lin, Weixing Xi, Yingyu Yao
Acinetobacter baumannii has emerged worldwide as a dominant pathogen in nosocomial infections. In this study, we report the draft genome sequence of a clinical multidrug-resistant (MDR) A. baumannii ST191 (CC92) strain. Whole-genome sequencing of the isolate was performed using an Illumina HiSeq™ 2500 system, and bioinformatics analysis was also performed. The draft genome length was 4,259,210bp, harbouring 14 gene sequences relevant to antibiotic resistance. Antimicrobial susceptibility testing revealed that the isolate was resistant to all of the tested antibiotics except for tigecycline and colistin...
May 30, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28567543/risk-factors-for-recurrent-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infection-a-prospective-cohort-study
#13
Maddalena Giannella, Elena Graziano, Lorenzo Marconi, Nicolo Girometti, Michele Bartoletti, Sara Tedeschi, Fabio Tumietto, Francesco Cristini, Simone Ambretti, Andrea Berlingeri, Russell E Lewis, Pierluigi Viale
To assess risk factors for recurrent carbapenem-resistant Klebsiella pneumoniae bloodstream-infection (CR-KP BSI), we performed a prospective observational cohort study of all consecutive adult patients cured of a CR-KP BSI at our hospital over a six-year period (June 2010 to June 2016). Maximum follow-up per patient was 180 days from the index blood cultures (BCs). Recurrent CR-KP BSI was defined as new evidence of positive BCs in patients with documented clinical response after completing a course of anti-CR-KP therapy...
June 1, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28559729/biosynthesis-of-oxytetracycline-by-streptomyces-rimosus-%C3%A2-past-present-and-future-directions-in-the-development%C3%A2-of-tetracycline-antibiotics
#14
REVIEW
Hrvoje Petković, Tadeja Lukežič, Jagoda Šušković
Natural tetracycline (TC) antibiotics were the first major class of therapeutics to earn the distinction of 'broad-spectrum antibiotics' and they have been used since the 1940s against a wide range of both Gram-positive and Gram-negative pathogens, mycoplasmas, intracellular chlamydiae, rickettsiae and protozoan parasites. The second generation of semisynthetic tetracyclines, such as minocycline and doxycycline, with improved antimicrobial potency, were introduced during the 1960s. Despite emerging resistance to TCs erupting during the 1980s, it was not until 2006, more than four decades later, that a third--generation TC, named tigecycline, was launched...
March 2017: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28559254/human-bile-reduces-antimicrobial-activity-of-selected-antibiotics-against-enterococcus-faecalis-and-escherichia-coli-in-vitro
#15
Beatrix Wulkersdorfer, David Jaros, Sabine Eberl, Stefan Poschner, Walter Jäger, Enrico Cosentini, Markus Zeitlinger, Richard Schwameis
It has been known from previous studies that body fluids, such as cerebrospinal fluid, lung surfactant and urine, have a strong impact on the bacterial killing of many anti-infective agents. However, the influence of human bile on the antimicrobial activity of antibiotics is widely unknown. Human bile was obtained and pooled from 11 patients undergoing cholecystectomy. After sterilisation of the bile fluid by gamma irradiation its effect on bacterial killing was investigated for linezolid (LZD) and tigecycline (TGC) against Enterococcus faecalis ATCC 29212...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28556623/ultrasonography-driven-combination-antibiotic-therapy-with-tigecycline-significantly-increases-survival-among-patients-with-neutropenic-enterocolitis-following-cytarabine-containing-chemotherapy-for-the-remission-induction-of-acute-myeloid-leukemia
#16
Novella Pugliese, Paola Salvatore, Dora Vita Iula, Maria Rosaria Catania, Federico Chiurazzi, Roberta Della Pepa, Claudio Cerchione, Marta Raimondo, Claudia Giordano, Luigia Simeone, Simona Caruso, Fabrizio Pane, Marco Picardi
Neutropenic enterocolitis (NEC) is an abdominal infection reported primarily in patients with acute myeloid leukemia (AML) following chemotherapy, especially cytarabine, a notable efficacious cytotoxic agent for AML remission. Specific data regarding the impact of different cytarabine schedules and/or antibacterial regimens for NEC are sparse. The aim of the study was to identify the predictors of outcome within 30 days of NEC onset. NEC episodes were retrospectively pinpointed among 440 patients with newly diagnosed AML hospitalized in our Institution, over a 10-year period, for receiving chemotherapy protocols with 100-6000 mg/m(2) daily of cytarabine...
May 26, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28556289/influence-of-regular-reporting-on-local-pseudomonas-aeruginosa-and-acinetobacter-spp-sensitivity-to-antibiotics-on-consumption-of-antibiotics-and-resistance-patterns
#17
Z M Djordjevic, M M Folic, S M Jankovic
WHAT IS KNOWN AND OBJECTIVE: Regular surveillance of antimicrobial resistance is an important component of multifaceted interventions directed at the problem with resistance of bacteria causing healthcare-associated infections (HAIs) in intensive care units (ICUs). Our aim was to analyse antimicrobial consumption and resistance among isolates of Pseudomonas aeruginosa and Acinetobacter spp. causing HAIs, before and after the introduction of mandatory reporting of resistance patterns to prescribers...
May 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28552659/antimicrobial-activity-evaluation-and-comparison-of-methods-of-susceptibility-for-klebsiella-pneumoniae-carbapenemase-kpc-producing-enterobacter-spp-isolates
#18
Daniele Zendrini Rechenchoski, Angélica Marim Lopes Dambrozio, Ana Carolina Polano Vivan, Paulo Alfonso Schuroff, Tatiane das Neves Burgos, Marsileni Pelisson, Marcia Regina Eches Perugini, Eliana Carolina Vespero
The production of KPC (Klebsiella pneumoniae carbapenemase) is the major mechanism of resistance to carbapenem agents in enterobacterias. In this context, forty KPC-producing Enterobacter spp. clinical isolates were studied. It was evaluated the activity of antimicrobial agents: polymyxin B, tigecycline, ertapenem, imipenem and meropenem, and was performed a comparison of the methodologies used to determine the susceptibility: broth microdilution, Etest(®) (bioMérieux), Vitek 2(®) automated system (bioMérieux) and disc diffusion...
May 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28546920/ocular-penetration-of-topically-applied-1-tigecycline-in-a-rabbit-model
#19
Yasar Sakarya, Rabia Sakarya, Muammer Ozcimen, Sertan Goktas, Serap Ozcimen, Ismail Alpfidan, Ismail Senol Ivacık, Erkan Erdogan, Servet Cetinkaya, Abdulkadir Bukus
AIM: To evaluate ocular penetration of topically applied 1% tigecycline. METHODS: Forty-two New Zealand White rabbits were divided into 3 groups. A 50 µL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15min for 60min (keratitis protocol). Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180min after the last drop. All animals in group 3 were euthanatized...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28542602/antimicrobial-resistance-status-of-enterococcus-from-australian-cattle-populations-at-slaughter
#20
Robert S Barlow, Kate E McMillan, Lesley L Duffy, Narelle Fegan, David Jordan, Glen E Mellor
Antimicrobial agents are used in cattle production systems for the prevention and control of bacterial associated diseases. A consequence of their use is the potential development of antimicrobial resistance (AMR). Enterococcus faecium and Enterococcus faecalis that are resistant to antimicrobials are of increased concern to public health officials throughout the world as they may compromise the ability of various treatment regimens to control disease and infection in human medicine. Australia is a major exporter of beef; however it does not have an ongoing surveillance system for AMR in cattle or foods derived from these animals...
2017: PloS One
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