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Margaret D. Allen

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https://www.readbyqxmd.com/read/27776247/delay-discounting-in-opioid-use-disorder-differences-between-heroin-and-prescription-opioid-users
#1
Sterling L Karakula, Roger D Weiss, Margaret L Griffin, Allison M Borges, Allen J Bailey, R Kathryn McHugh
BACKGROUND: Among those with opioid use disorder, heroin use is associated with poorer prognosis relative to use of prescription opioids alone. However, relatively little is known about distinguishing features between those who use heroin relative to those who use prescription opioids. In the present study we evaluated differences in delay discounting in those with opioid use disorder based on primary opioid of use. Delay discounting is associated with a range of negative outcomes and is an important therapeutic target in this population...
October 17, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27308046/crystal-structure-of-tris-pyridin-2-ylmeth-yl-amine-%C3%AE%C2%BA-4-n-copper-ii-bromide
#2
Emma C Bridgman, Megan M Doherty, Kaleigh A Ellis, Elizabeth A Homer, Taylor N Lashbrook, Margaret E Mraz, Gina C Pernesky, Emma M Vreeke, Kayode D Oshin, Allen G Oliver
In the asymmetric unit of the title compound, [CuBr(C18H18N4)]Br, there are three crystallographically independent cations. One of the cations exhibits positional disorder of the pyridin-2-yl-methyl groups over two sets of sites with refined occupancies of 0.672 (8) and 0.328 (8). The outer-sphere bromine counter-ion is severely disordered over multiple sites. In each cation, the Cu(II) ion is coordinated by the four N atoms of the tris-(pyridin-2-ylmeth-yl)amine ligand and one bromine and adopts a slightly distorted trigonal-bipyramidal geometry...
June 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27276562/exome-sequencing-and-the-management-of-neurometabolic-disorders
#3
Maja Tarailo-Graovac, Casper Shyr, Colin J Ross, Gabriella A Horvath, Ramona Salvarinova, Xin C Ye, Lin-Hua Zhang, Amit P Bhavsar, Jessica J Y Lee, Britt I Drögemöller, Mena Abdelsayed, Majid Alfadhel, Linlea Armstrong, Matthias R Baumgartner, Patricie Burda, Mary B Connolly, Jessie Cameron, Michelle Demos, Tammie Dewan, Janis Dionne, A Mark Evans, Jan M Friedman, Ian Garber, Suzanne Lewis, Jiqiang Ling, Rupasri Mandal, Andre Mattman, Margaret McKinnon, Aspasia Michoulas, Daniel Metzger, Oluseye A Ogunbayo, Bojana Rakic, Jacob Rozmus, Peter Ruben, Bryan Sayson, Saikat Santra, Kirk R Schultz, Kathryn Selby, Paul Shekel, Sandra Sirrs, Cristina Skrypnyk, Andrea Superti-Furga, Stuart E Turvey, Margot I Van Allen, David Wishart, Jiang Wu, John Wu, Dimitrios Zafeiriou, Leo Kluijtmans, Ron A Wevers, Patrice Eydoux, Anna M Lehman, Hilary Vallance, Sylvia Stockler-Ipsiroglu, Graham Sinclair, Wyeth W Wasserman, Clara D van Karnebeek
BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn errors of metabolism, since many of these disorders are responsive to therapy that targets pathophysiological features at the molecular or cellular level. METHODS: To uncover the genetic basis of potentially treatable inborn errors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the discrete components of a patient's clinical and biochemical phenotype) with whole-exome sequencing analysis through a semiautomated bioinformatics pipeline in consecutively enrolled patients with intellectual developmental disorder and unexplained metabolic phenotypes...
June 9, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27043413/acidic-chitinase-primes-the-protective-immune-response-to-gastrointestinal-nematodes
#4
Kevin M Vannella, Thirumalai R Ramalingam, Kevin M Hart, Rafael de Queiroz Prado, Joshua Sciurba, Luke Barron, Lee A Borthwick, Allen D Smith, Margaret Mentink-Kane, Sandra White, Robert W Thompson, Allen W Cheever, Kevin Bock, Ian Moore, Lori J Fitz, Joseph F Urban, Thomas A Wynn
Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment of type 2 inflammation in the lung in response to allergens or helminths. In contrast, AMCase-deficient mice showed a profound defect in type 2 immunity following infection with the chitin-containing gastrointestinal nematodes Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri...
May 2016: Nature Immunology
https://www.readbyqxmd.com/read/26921161/effects-of-a-video-on-organ-donation-consent-among-primary-care-patients-a-randomized-controlled-trial
#5
J Daryl Thornton, Catherine Sullivan, Jeffrey M Albert, Maria Cedeño, Bridget Patrick, Julie Pencak, Kristine A Wong, Margaret D Allen, Linda Kimble, Heather Mekesa, Gordon Bowen, Ashwini R Sehgal
BACKGROUND: Low organ donation rates remain a major barrier to organ transplantation. OBJECTIVE: We aimed to determine the effect of a video and patient cueing on organ donation consent among patients meeting with their primary care provider. DESIGN: This was a randomized controlled trial between February 2013 and May 2014. SETTING: The waiting rooms of 18 primary care clinics of a medical system in Cuyahoga County, Ohio...
August 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/26870592/crystal-structure-of-bis-2-amino-ethyl-%C3%AE%C2%BAn-2-4-tri-fluoro-meth-yl-benzyl-idene-amino-eth-yl-amine-%C3%AE%C2%BAn-di-chlorido-copper-ii
#6
Katherine A Bussey, Annie R Cavalier, Margaret E Mraz, Ashley S Holderread, Kayode D Oshin, Allen G Oliver, Matthias Zeller
The Cu(II) atom in the title compound, [CuCl2(C14H21F3N4)], adopts a coordination geometry that is between distorted square-based pyramidal and very Jahn-Teller-elongated octa-hedral. It is coordinated by three N atoms from the bis-(2-amino-eth-yl)(2-{[4-(tri-fluoro-meth-yl)benzyl-idene]amino}-eth-yl)amine and two chloride ligands. The two crystallographically unique copper complexes present in the asymmetric unit exhibit noticeable differences in the coordination bond lengths. Considering the Cu(II) atoms as having square-pyramidal geometry, the basal Cu-Cl bond lengths are typical [2...
January 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/26860627/advancing-product-quality-a-summary-of-the-second-fda-pqri-conference
#7
Lawrence X Yu, Ilgaz Akseli, Barbara Allen, Gregory Amidon, Tara Gooen Bizjak, Ashley Boam, Margaret Caulk, David Doleski, Joseph Famulare, Adam C Fisher, Scott Furness, Brian Hasselbalch, Henry Havel, Stephen W Hoag, Robert Iser, Bruce D Johnson, Robert Ju, Paula Katz, Emanuela Lacana, Sau L Lee, Richard Lostritto, Grace McNally, Mehul Mehta, Ganapathy Mohan, Moheb Nasr, Roger Nosal, Mary Oates, Thomas O'Connor, Jim Polli, G K Raju, Mahesh Ramanadham, Giuseppe Randazzo, Susan Rosencrance, Anna Schwendeman, Arzu Selen, Paul Seo, Vinod Shah, Ramesh Sood, Michael P Thien, Tony Tong, Bernhardt L Trout, Katherine Tyner, Siva Vaithiyalingam, Martin VanTrieste, Fionnuala Walsh, Russell Wesdyk, Janet Woodcock, Geoffrey Wu, Larisa Wu, Louis Yu, Diane Zezza
No abstract text is available yet for this article.
March 2016: AAPS Journal
https://www.readbyqxmd.com/read/26364544/global-regional-and-national-comparative-risk-assessment-of-79-behavioural-environmental-and-occupational-and-metabolic-risks-or-clusters-of-risks-in-188-countries-1990-2013-a-systematic-analysis-for-the-global-burden-of-disease-study-2013
#8
COMPARATIVE STUDY
Mohammad H Forouzanfar, Lily Alexander, H Ross Anderson, Victoria F Bachman, Stan Biryukov, Michael Brauer, Richard Burnett, Daniel Casey, Matthew M Coates, Aaron Cohen, Kristen Delwiche, Kara Estep, Joseph J Frostad, K C Astha, Hmwe H Kyu, Maziar Moradi-Lakeh, Marie Ng, Erica Leigh Slepak, Bernadette A Thomas, Joseph Wagner, Gunn Marit Aasvang, Cristiana Abbafati, Ayse Abbasoglu Ozgoren, Foad Abd-Allah, Semaw F Abera, Victor Aboyans, Biju Abraham, Jerry Puthenpurakal Abraham, Ibrahim Abubakar, Niveen M E Abu-Rmeileh, Tania C Aburto, Tom Achoki, Ademola Adelekan, Koranteng Adofo, Arsène K Adou, José C Adsuar, Ashkan Afshin, Emilie E Agardh, Mazin J Al Khabouri, Faris H Al Lami, Sayed Saidul Alam, Deena Alasfoor, Mohammed I Albittar, Miguel A Alegretti, Alicia V Aleman, Zewdie A Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, Mohammed K Ali, François Alla, Peter Allebeck, Peter J Allen, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Adansi A Amankwaa, Azmeraw T Amare, Emmanuel A Ameh, Omid Ameli, Heresh Amini, Walid Ammar, Benjamin O Anderson, Carl Abelardo T Antonio, Palwasha Anwari, Solveig Argeseanu Cunningham, Johan Arnlöv, Valentina S Arsic Arsenijevic, Al Artaman, Rana J Asghar, Reza Assadi, Lydia S Atkins, Charles Atkinson, Marco A Avila, Baffour Awuah, Alaa Badawi, Maria C Bahit, Talal Bakfalouni, Kalpana Balakrishnan, Shivanthi Balalla, Ravi Kumar Balu, Amitava Banerjee, Ryan M Barber, Suzanne L Barker-Collo, Simon Barquera, Lars Barregard, Lope H Barrero, Tonatiuh Barrientos-Gutierrez, Ana C Basto-Abreu, Arindam Basu, Sanjay Basu, Mohammed O Basulaiman, Carolina Batis Ruvalcaba, Justin Beardsley, Neeraj Bedi, Tolesa Bekele, Michelle L Bell, Corina Benjet, Derrick A Bennett, Habib Benzian, Eduardo Bernabé, Tariku J Beyene, Neeraj Bhala, Ashish Bhalla, Zulfiqar A Bhutta, Boris Bikbov, Aref A Bin Abdulhak, Jed D Blore, Fiona M Blyth, Megan A Bohensky, Berrak Bora Başara, Guilherme Borges, Natan M Bornstein, Dipan Bose, Soufiane Boufous, Rupert R Bourne, Michael Brainin, Alexandra Brazinova, Nicholas J Breitborde, Hermann Brenner, Adam D M Briggs, David M Broday, Peter M Brooks, Nigel G Bruce, Traolach S Brugha, Bert Brunekreef, Rachelle Buchbinder, Linh N Bui, Gene Bukhman, Andrew G Bulloch, Michael Burch, Peter G J Burney, Ismael R Campos-Nonato, Julio C Campuzano, Alejandra J Cantoral, Jack Caravanos, Rosario Cárdenas, Elisabeth Cardis, David O Carpenter, Valeria Caso, Carlos A Castañeda-Orjuela, Ruben E Castro, Ferrán Catalá-López, Fiorella Cavalleri, Alanur Çavlin, Vineet K Chadha, Jung-Chen Chang, Fiona J Charlson, Honglei Chen, Wanqing Chen, Zhengming Chen, Peggy P Chiang, Odgerel Chimed-Ochir, Rajiv Chowdhury, Costas A Christophi, Ting-Wu Chuang, Sumeet S Chugh, Massimo Cirillo, Thomas K D Claßen, Valentina Colistro, Mercedes Colomar, Samantha M Colquhoun, Alejandra G Contreras, Cyrus Cooper, Kimberly Cooperrider, Leslie T Cooper, Josef Coresh, Karen J Courville, Michael H Criqui, Lucia Cuevas-Nasu, James Damsere-Derry, Hadi Danawi, Lalit Dandona, Rakhi Dandona, Paul I Dargan, Adrian Davis, Dragos V Davitoiu, Anand Dayama, E Filipa de Castro, Vanessa De la Cruz-Góngora, Diego De Leo, Graça de Lima, Louisa Degenhardt, Borja del Pozo-Cruz, Robert P Dellavalle, Kebede Deribe, Sarah Derrett, Don C Des Jarlais, Muluken Dessalegn, Gabrielle A deVeber, Karen M Devries, Samath D Dharmaratne, Mukesh K Dherani, Daniel Dicker, Eric L Ding, Klara Dokova, E Ray Dorsey, Tim R Driscoll, Leilei Duan, Adnan M Durrani, Beth E Ebel, Richard G Ellenbogen, Yousef M Elshrek, Matthias Endres, Sergey P Ermakov, Holly E Erskine, Babak Eshrati, Alireza Esteghamati, Saman Fahimi, Emerito Jose A Faraon, Farshad Farzadfar, Derek F J Fay, Valery L Feigin, Andrea B Feigl, Seyed-Mohammad Fereshtehnejad, Alize J Ferrari, Cleusa P Ferri, Abraham D Flaxman, Thomas D Fleming, Nataliya Foigt, Kyle J Foreman, Urbano Fra Paleo, Richard C Franklin, Belinda Gabbe, Lynne Gaffikin, Emmanuela Gakidou, Amiran Gamkrelidze, Fortuné G Gankpé, Ron T Gansevoort, Francisco A García-Guerra, Evariste Gasana, Johanna M Geleijnse, Bradford D Gessner, Pete Gething, Katherine B Gibney, Richard F Gillum, Ibrahim A M Ginawi, Maurice Giroud, Giorgia Giussani, Shifalika Goenka, Ketevan Goginashvili, Hector Gomez Dantes, Philimon Gona, Teresita Gonzalez de Cosio, Dinorah González-Castell, Carolyn C Gotay, Atsushi Goto, Hebe N Gouda, Richard L Guerrant, Harish C Gugnani, Francis Guillemin, David Gunnell, Rahul Gupta, Rajeev Gupta, Reyna A Gutiérrez, Nima Hafezi-Nejad, Holly Hagan, Maria Hagstromer, Yara A Halasa, Randah R Hamadeh, Mouhanad Hammami, Graeme J Hankey, Yuantao Hao, Hilda L Harb, Tilahun Nigatu Haregu, Josep Maria Haro, Rasmus Havmoeller, Simon I Hay, Mohammad T Hedayati, Ileana B Heredia-Pi, Lucia Hernandez, Kyle R Heuton, Pouria Heydarpour, Martha Hijar, Hans W Hoek, Howard J Hoffman, John C Hornberger, H Dean Hosgood, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Howard Hu, Cheng Huang, John J Huang, Bryan J Hubbell, Laetitia Huiart, Abdullatif Husseini, Marissa L Iannarone, Kim M Iburg, Bulat T Idrisov, Nayu Ikeda, Kaire Innos, Manami Inoue, Farhad Islami, Samaya Ismayilova, Kathryn H Jacobsen, Henrica A Jansen, Deborah L Jarvis, Simerjot K Jassal, Alejandra Jauregui, Sudha Jayaraman, Panniyammakal Jeemon, Paul N Jensen, Vivekanand Jha, Fan Jiang, Guohong Jiang, Ying Jiang, Jost B Jonas, Knud Juel, Haidong Kan, Sidibe S Kany Roseline, Nadim E Karam, André Karch, Corine K Karema, Ganesan Karthikeyan, Anil Kaul, Norito Kawakami, Dhruv S Kazi, Andrew H Kemp, Andre P Kengne, Andre Keren, Yousef S Khader, Shams Eldin Ali Hassan Khalifa, Ejaz A Khan, Young-Ho Khang, Shahab Khatibzadeh, Irma Khonelidze, Christian Kieling, Daniel Kim, Sungroul Kim, Yunjin Kim, Ruth W Kimokoti, Yohannes Kinfu, Jonas M Kinge, Brett M Kissela, Miia Kivipelto, Luke D Knibbs, Ann Kristin Knudsen, Yoshihiro Kokubo, M Rifat Kose, Soewarta Kosen, Alexander Kraemer, Michael Kravchenko, Sanjay Krishnaswami, Hans Kromhout, Tiffany Ku, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Ernst J Kuipers, Chanda Kulkarni, Veena S Kulkarni, G Anil Kumar, Gene F Kwan, Taavi Lai, Arjun Lakshmana Balaji, Ratilal Lalloo, Tea Lallukka, Hilton Lam, Qing Lan, Van C Lansingh, Heidi J Larson, Anders Larsson, Dennis O Laryea, Pablo M Lavados, Alicia E Lawrynowicz, Janet L Leasher, Jong-Tae Lee, James Leigh, Ricky Leung, Miriam Levi, Yichong Li, Yongmei Li, Juan Liang, Xiaofeng Liang, Stephen S Lim, M Patrice Lindsay, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Giancarlo Logroscino, Stephanie J London, Nancy Lopez, Joannie Lortet-Tieulent, Paulo A Lotufo, Rafael Lozano, Raimundas Lunevicius, Jixiang Ma, Stefan Ma, Vasco M P Machado, Michael F MacIntyre, Carlos Magis-Rodriguez, Abbas A Mahdi, Marek Majdan, Reza Malekzadeh, Srikanth Mangalam, Christopher C Mapoma, Marape Marape, Wagner Marcenes, David J Margolis, Christopher Margono, Guy B Marks, Randall V Martin, Melvin B Marzan, Mohammad T Mashal, Felix Masiye, Amanda J Mason-Jones, Kunihiro Matsushita, Richard Matzopoulos, Bongani M Mayosi, Tasara T Mazorodze, Abigail C McKay, Martin McKee, Abigail McLain, Peter A Meaney, Catalina Medina, Man Mohan Mehndiratta, Fabiola Mejia-Rodriguez, Wubegzier Mekonnen, Yohannes A Melaku, Michele Meltzer, Ziad A Memish, Walter Mendoza, George A Mensah, Atte Meretoja, Francis Apolinary Mhimbira, Renata Micha, Ted R Miller, Edward J Mills, Awoke Misganaw, Santosh Mishra, Norlinah Mohamed Ibrahim, Karzan A Mohammad, Ali H Mokdad, Glen L Mola, Lorenzo Monasta, Julio C Montañez Hernandez, Marcella Montico, Ami R Moore, Lidia Morawska, Rintaro Mori, Joanna Moschandreas, Wilkister N Moturi, Dariush Mozaffarian, Ulrich O Mueller, Mitsuru Mukaigawara, Erin C Mullany, Kinnari S Murthy, Mohsen Naghavi, Ziad Nahas, Aliya Naheed, Kovin S Naidoo, Luigi Naldi, Devina Nand, Vinay Nangia, K M Venkat Narayan, Denis Nash, Bruce Neal, Chakib Nejjari, Sudan P Neupane, Charles R Newton, Frida N Ngalesoni, Jean de Dieu Ngirabega, Grant Nguyen, Nhung T Nguyen, Mark J Nieuwenhuijsen, Muhammad I Nisar, José R Nogueira, Joan M Nolla, Sandra Nolte, Ole F Norheim, Rosana E Norman, Bo Norrving, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Bolajoko O Olusanya, Saad B Omer, John Nelson Opio, Ricardo Orozco, Rodolfo S Pagcatipunan, Amanda W Pain, Jeyaraj D Pandian, Carlo Irwin A Panelo, Christina Papachristou, Eun-Kee Park, Charles D Parry, Angel J Paternina Caicedo, Scott B Patten, Vinod K Paul, Boris I Pavlin, Neil Pearce, Lilia S Pedraza, Andrea Pedroza, Ljiljana Pejin Stokic, Ayfer Pekericli, David M Pereira, Rogelio Perez-Padilla, Fernando Perez-Ruiz, Norberto Perico, Samuel A L Perry, Aslam Pervaiz, Konrad Pesudovs, Carrie B Peterson, Max Petzold, Michael R Phillips, Hwee Pin Phua, Dietrich Plass, Dan Poenaru, Guilherme V Polanczyk, Suzanne Polinder, Constance D Pond, C Arden Pope, Daniel Pope, Svetlana Popova, Farshad Pourmalek, John Powles, Dorairaj Prabhakaran, Noela M Prasad, Dima M Qato, Amado D Quezada, D Alex A Quistberg, Lionel Racapé, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Murugesan Raju, Ivo Rakovac, Saleem M Rana, Mayuree Rao, Homie Razavi, K Srinath Reddy, Amany H Refaat, Jürgen Rehm, Giuseppe Remuzzi, Antonio L Ribeiro, Patricia M Riccio, Lee Richardson, Anne Riederer, Margaret Robinson, Anna Roca, Alina Rodriguez, David Rojas-Rueda, Isabelle Romieu, Luca Ronfani, Robin Room, Nobhojit Roy, George M Ruhago, Lesley Rushton, Nsanzimana Sabin, Ralph L Sacco, Sukanta Saha, Ramesh Sahathevan, Mohammad Ali Sahraian, Joshua A Salomon, Deborah Salvo, Uchechukwu K Sampson, Juan R Sanabria, Luz Maria Sanchez, Tania G Sánchez-Pimienta, Lidia Sanchez-Riera, Logan Sandar, Itamar S Santos, Amir Sapkota, Maheswar Satpathy, James E Saunders, Monika Sawhney, Mete I Saylan, Peter Scarborough, Jürgen C Schmidt, Ione J C Schneider, Ben Schöttker, David C Schwebel, James G Scott, Soraya Seedat, Sadaf G Sepanlou, Berrin Serdar, Edson E Servan-Mori, Gavin Shaddick, Saeid Shahraz, Teresa Shamah Levy, Siyi Shangguan, Jun She, Sara Sheikhbahaei, Kenji Shibuya, Hwashin H Shin, Yukito Shinohara, Rahman Shiri, Kawkab Shishani, Ivy Shiue, Inga D Sigfusdottir, Donald H Silberberg, Edgar P Simard, Shireen Sindi, Abhishek Singh, Gitanjali M Singh, Jasvinder A Singh, Vegard Skirbekk, Karen Sliwa, Michael Soljak, Samir Soneji, Kjetil Søreide, Sergey Soshnikov, Luciano A Sposato, Chandrashekhar T Sreeramareddy, Nicolas J C Stapelberg, Vasiliki Stathopoulou, Nadine Steckling, Dan J Stein, Murray B Stein, Natalie Stephens, Heidi Stöckl, Kurt Straif, Konstantinos Stroumpoulis, Lela Sturua, Bruno F Sunguya, Soumya Swaminathan, Mamta Swaroop, Bryan L Sykes, Karen M Tabb, Ken Takahashi, Roberto T Talongwa, Nikhil Tandon, David Tanne, Marcel Tanner, Mohammad Tavakkoli, Braden J Te Ao, Carolina M Teixeira, Martha M Téllez Rojo, Abdullah S Terkawi, José Luis Texcalac-Sangrador, Sarah V Thackway, Blake Thomson, Andrew L Thorne-Lyman, Amanda G Thrift, George D Thurston, Taavi Tillmann, Myriam Tobollik, Marcello Tonelli, Fotis Topouzis, Jeffrey A Towbin, Hideaki Toyoshima, Jefferson Traebert, Bach X Tran, Leonardo Trasande, Matias Trillini, Ulises Trujillo, Zacharie Tsala Dimbuene, Miltiadis Tsilimbaris, Emin Murat Tuzcu, Uche S Uchendu, Kingsley N Ukwaja, Selen B Uzun, Steven van de Vijver, Rita Van Dingenen, Coen H van Gool, Jim van Os, Yuri Y Varakin, Tommi J Vasankari, Ana Maria N Vasconcelos, Monica S Vavilala, Lennert J Veerman, Gustavo Velasquez-Melendez, N Venketasubramanian, Lakshmi Vijayakumar, Salvador Villalpando, Francesco S Violante, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Gregory R Wagner, Stephen G Waller, Mitchell T Wallin, Xia Wan, Haidong Wang, JianLi Wang, Linhong Wang, Wenzhi Wang, Yanping Wang, Tati S Warouw, Charlotte H Watts, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, K Ryan Wessells, Ronny Westerman, Harvey A Whiteford, James D Wilkinson, Hywel C Williams, Thomas N Williams, Solomon M Woldeyohannes, Charles D A Wolfe, John Q Wong, Anthony D Woolf, Jonathan L Wright, Brittany Wurtz, Gelin Xu, Lijing L Yan, Gonghuan Yang, Yuichiro Yano, Pengpeng Ye, Muluken Yenesew, Gökalp K Yentür, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Zourkaleini Younoussi, Chuanhua Yu, Maysaa E Zaki, Yong Zhao, Yingfeng Zheng, Maigeng Zhou, Jun Zhu, Shankuan Zhu, Xiaonong Zou, Joseph R Zunt, Alan D Lopez, Theo Vos, Christopher J Murray
BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution...
December 5, 2015: Lancet
https://www.readbyqxmd.com/read/26334870/content-validity-of-the-hypogonadism-impact-of-symptoms-questionnaire-his-q-a-patient-reported-outcome-measure-to-evaluate-symptoms-of-hypogonadism
#9
Heather L Gelhorn, Margaret K Vernon, Katie D Stewart, Michael G Miller, Meryl Brod, Stanley E Althof, Leonard R DeRogatis, Adrian Dobs, Allen D Seftel, Dennis A Revicki
BACKGROUND: Hypogonadism, or low testosterone, is a common disorder. There are currently no patient-reported outcome (PRO) instruments designed to comprehensively evaluate the symptoms of hypogonadism and to detect changes in these symptoms in response to treatment. OBJECTIVE: The purpose of this study was to develop a PRO instrument, the Hypogonadism Impact of Symptoms Questionnaire (HIS-Q) and to assess its content validity. METHODS: A literature review, expert clinician input, and qualitative concept elicitation with 39 male hypogonadism patients (four focus groups: n = 25; individual interviews: n = 14; mean age 52...
April 2016: Patient
https://www.readbyqxmd.com/read/26247145/color-coded-prefilled-medication-syringes-decrease-time-to-delivery-and-dosing-errors-in-simulated-prehospital-pediatric-resuscitations-a-randomized-crossover-trial
#10
RANDOMIZED CONTROLLED TRIAL
Allen D Stevens, Caleb Hernandez, Seth Jones, Maria E Moreira, Jason R Blumen, Emily Hopkins, Margaret Sande, Katherine Bakes, Jason S Haukoos
BACKGROUND: Medication dosing errors remain commonplace and may result in potentially life-threatening outcomes, particularly for pediatric patients where dosing often requires weight-based calculations. Novel medication delivery systems that may reduce dosing errors resonate with national healthcare priorities. Our goal was to evaluate novel, prefilled medication syringes labeled with color-coded volumes corresponding to the weight-based dosing of the Broselow Tape, compared to conventional medication administration, in simulated prehospital pediatric resuscitation scenarios...
November 2015: Resuscitation
https://www.readbyqxmd.com/read/26156797/plasma-micronutrient-concentrations-are-altered-by-antiretroviral-therapy-and-lipid-based-nutrient-supplements-in-lactating-hiv-infected-malawian-women
#11
Valerie L Flax, Linda S Adair, Lindsay H Allen, Setarah Shahab-Ferdows, Daniela Hampel, Charles S Chasela, Gerald Tegha, Eric J Daza, Amanda Corbett, Nicole L Davis, Deborah Kamwendo, Athena P Kourtis, Charles M van der Horst, Denise J Jamieson, Margaret E Bentley
BACKGROUND: Little is known about the influence of antiretroviral therapy with or without micronutrient supplementation on the micronutrient concentrations of HIV-infected lactating women in resource-constrained settings. OBJECTIVE: We examined associations of highly active antiretroviral therapy (HAART) and lipid-based nutrient supplements (LNS) with concentrations of selected micronutrients in HIV-infected Malawian women at 24 wk postpartum. METHODS: Plasma micronutrient concentrations were measured in a subsample (n = 690) of Breastfeeding, Antiretrovirals, and Nutrition (BAN) study participants who were randomly assigned at delivery to receive HAART, LNS, HAART+LNS, or no HAART/no LNS (control)...
August 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/26146388/structural-studies-of-prop-2-en-1-yl-bis-pyridin-2-yl-methylidene-amine-hetero-scorpionate-copper-complexes
#12
Katherine A Bussey, Annie R Cavalier, Jennifer R Connell, Margaret E Mraz, Kayode D Oshin, Tomislav Pintauer, Allen G Oliver
The structures of five compounds consisting of (prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine complexed with copper in both the Cu(I) and Cu(II) oxidation states are presented, namely chlorido{(prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine-κ(3)N,N',N''}copper(I) 0.18-hydrate, [CuCl(C15H17N3)]·0.18H2O, (1), catena-poly[[copper(I)-μ2-(prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine-κ(5)N,N',N'':C(2),C(3)] perchlorate acetonitrile monosolvate], {[Cu(C15H17N3)]ClO4·CH3CN}n, (2), dichlorido{(prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine-κ(3)N,N',N''}copper(II) dichloromethane monosolvate, [CuCl2(C15H17N3)]·CH2Cl2, (3), chlorido{(prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine-κ(3)N,N',N''}copper(II) perchlorate, [CuCl(C15H17N3)]ClO4, (4), and di-μ-chlorido-bis({(prop-2-en-1-yl)bis[(pyridin-2-yl)methylidene]amine-κ(3)N,N',N''}copper(II)) bis(tetraphenylborate), [Cu2Cl2(C15H17N3)2][(C6H5)4B]2, (5)...
July 2015: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/26070773/can-cytoprotective-cobalt-protoporphyrin-protect-skeletal-muscle-and-muscle-derived-stem-cells-from-ischemic-injury
#13
Heather-Marie P Wilson, Robert E Welikson, Jun Luo, Thomas J Kean, Baohong Cao, James E Dennis, Margaret D Allen
BACKGROUND: Extremity trauma is the most common injury seen in combat hospitals as well as in civilian trauma centers. Major skeletal muscle injuries that are complicated by ischemia often result in substantial muscle loss, residual disability, or even amputation, yet few treatment options are available. A therapy that would increase skeletal muscle tolerance to hypoxic damage could reduce acute myocyte loss and enhance preservation of muscle mass in these situations. QUESTIONS/PURPOSES: In these experiments, we investigated (1) whether cobalt protoporphyrin (CoPP), a pharmacologic inducer of cytoprotective heme oxygenase-1 (HO-1), would upregulate HO-1 expression and activity in skeletal muscle, tested in muscle-derived stem cells (MDSCs); and (2) whether CoPP exposure would protect MDSCs from cell death during in vitro hypoxia/reoxygenation...
September 2015: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/25844195/crystal-structure-of-but-3-en-1-yl-bis-pyridin-2-yl-meth-yl-amine-%C3%AE%C2%BA-3-n-n-n-di-chlorido-copper-ii-diethyl-ether-hemisolvate
#14
Katherine A Bussey, Jennifer R Connell, Annie R McGlone, Margaret E Mraz, Kayode D Oshin, Tomislav Pintauer, Allen G Oliver
The five-coordinate Cu(II) atom in the title complex [CuCl2(C16H19N3)]·0.5C4H10O, adopts a near-ideal square-pyramidal geometry (τ-5 = 0.01). The apical Cu-Cl distance is 0.2626 (6) Å longer than the basal Cu-Cl distance. Weak C-H⋯Cl interactions between pyridine rings and the Cl atoms of adjacent complex molecules are present. The solvent molecule, located on a twofold rotation axis, is situated in the voids of this arrangement. Copper atoms coordinated by tridentate nitro-gen-containing ligands have been found to be excellent promoters of Atom Transfer Radical Addition (ATRA) reactions...
March 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/25760519/five-reasons-to-consider-phytophthora-infestans-a-reemerging-pathogen
#15
REVIEW
W E Fry, P R J Birch, H S Judelson, N J Grünwald, G Danies, K L Everts, A J Gevens, B K Gugino, D A Johnson, S B Johnson, M T McGrath, K L Myers, J B Ristaino, P D Roberts, G Secor, C D Smart
Phytophthora infestans has been a named pathogen for well over 150 years and yet it continues to "emerge", with thousands of articles published each year on it and the late blight disease that it causes. This review explores five attributes of this oomycete pathogen that maintain this constant attention. First, the historical tragedy associated with this disease (Irish potato famine) causes many people to be fascinated with the pathogen. Current technology now enables investigators to answer some questions of historical significance...
July 2015: Phytopathology
https://www.readbyqxmd.com/read/25702581/oncogenic-properties-of-apoptotic-tumor-cells-in-aggressive-b-cell-lymphoma
#16
Catriona A Ford, Sofia Petrova, John D Pound, Jorine J L P Voss, Lynsey Melville, Margaret Paterson, Sarah L Farnworth, Awen M Gallimore, Simone Cuff, Helen Wheadon, Edwina Dobbin, Carol Anne Ogden, Ingrid E Dumitriu, Donald R Dunbar, Paul G Murray, Dominik Ruckerl, Judith E Allen, David A Hume, Nico van Rooijen, John R Goodlad, Tom C Freeman, Christopher D Gregory
BACKGROUND: Cells undergoing apoptosis are known to modulate their tissue microenvironments. By acting on phagocytes, notably macrophages, apoptotic cells inhibit immunological and inflammatory responses and promote trophic signaling pathways. Paradoxically, because of their potential to cause death of tumor cells and thereby militate against malignant disease progression, both apoptosis and tumor-associated macrophages (TAMs) are often associated with poor prognosis in cancer. We hypothesized that, in progression of malignant disease, constitutive loss of a fraction of the tumor cell population through apoptosis could yield tumor-promoting effects...
March 2, 2015: Current Biology: CB
https://www.readbyqxmd.com/read/25701295/color-coded-prefilled-medication-syringes-decrease-time-to-delivery-and-dosing-error-in-simulated-emergency-department-pediatric-resuscitations
#17
RANDOMIZED CONTROLLED TRIAL
Maria E Moreira, Caleb Hernandez, Allen D Stevens, Seth Jones, Margaret Sande, Jason R Blumen, Emily Hopkins, Katherine Bakes, Jason S Haukoos
STUDY OBJECTIVE: The Institute of Medicine has called on the US health care system to identify and reduce medical errors. Unfortunately, medication dosing errors remain commonplace and may result in potentially life-threatening outcomes, particularly for pediatric patients when dosing requires weight-based calculations. Novel medication delivery systems that may reduce dosing errors resonate with national health care priorities. Our goal was to evaluate novel, prefilled medication syringes labeled with color-coded volumes corresponding to the weight-based dosing of the Broselow Tape, compared with conventional medication administration, in simulated pediatric emergency department (ED) resuscitation scenarios...
August 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25575913/national-healthcare-safety-network-report-data-summary-for-2013-device-associated-module
#18
Margaret A Dudeck, Jonathan R Edwards, Katherine Allen-Bridson, Cindy Gross, Paul J Malpiedi, Kelly D Peterson, Daniel A Pollock, Lindsey M Weiner, Dawn M Sievert
No abstract text is available yet for this article.
March 1, 2015: American Journal of Infection Control
https://www.readbyqxmd.com/read/25324900/association-of-mapt-haplotypes-with-alzheimer-s-disease-risk-and-mapt-brain-gene-expression-levels
#19
Mariet Allen, Michaela Kachadoorian, Zachary Quicksall, Fanggeng Zou, High Seng Chai, Curtis Younkin, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Siddharth Krishnan, Thuy Nguyen, Li Ma, Kimberly Malphrus, Sarah Lincoln, Gina Bisceglio, Christopher P Kolbert, Jin Jen, Shubhabrata Mukherjee, John K Kauwe, Paul K Crane, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Joseph E Parisi, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
INTRODUCTION: MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer's disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although insufficient power and incomplete assessment of MAPT haplotypes may account for this. METHODS: We examined the association of MAPT haplotypes with LOAD risk in more than 20,000 subjects (n-cases = 9,814, n-controls = 11,550) from Mayo Clinic (n-cases = 2,052, n-controls = 3,406) and the Alzheimer's Disease Genetics Consortium (ADGC, n-cases = 7,762, n-controls = 8,144)...
2014: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/25256757/the-rbmx-gene-as-a-candidate-for-the-shashi-x-linked-intellectual-disability-syndrome
#20
V Shashi, P Xie, K Schoch, D B Goldstein, T D Howard, M N Berry, C E Schwartz, K Cronin, S Sliwa, A Allen, A C Need
A novel X-linked intellectual disability (XLID) syndrome with moderate intellectual disability and distinguishing craniofacial dysmorphisms had been previously mapped to the Xq26-q27 interval. On whole exome sequencing in the large family originally reported with this disorder, we identified a 23 bp frameshift deletion in the RNA binding motif protein X-linked (RBMX) gene at Xq26 in the affected males (n = 7), one carrier female, absent in unaffected males (n = 2) and in control databases (7800 exomes)...
October 2015: Clinical Genetics
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