Olivia C Leavy, Anne F Goemans, Amy D Stockwell, Richard J Allen, Beatriz Guillen-Guio, Tamara Hernandez-Beeftink, Ayodeji Adegunsoye, Helen L Booth, Paul Cullinan, William A Fahy, Tasha E Fingerlin, Harvinder S Virk, Ian P Hall, Simon P Hart, Mike R Hill, Nik Hirani, Richard B Hubbard, Naftali Kaminski, Shwu-Fan Ma, Robin J McAnulty, X Rebecca Sheng, Ann B Millar, Maria Molina-Molina, Vidya Navaratnam, Margaret Neighbors, Helen Parfrey, Gauri Saini, Ian Sayers, Mary E Strek, Martin D Tobin, Moira Kb Whyte, Yingze Zhang, Toby M Maher, Philip L Molyneaux, Justin M Oldham, Brian L Yaspan, Carlos Flores, Fernando Martinez, Carl J Reynolds, David A Schwartz, Imre Noth, R Gisli Jenkins, Louise V Wain
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition that is more prevalent in males than females. The reasons for this are not fully understood, with differing environmental exposures due to historically sex-biased occupations, or diagnostic bias, being possible explanations. To date, over 20 independent genetic variants have been identified to be associated with IPF susceptibility, but these have been discovered when combining males and females. Our aim was to test for the presence of sex-specific associations with IPF susceptibility and assess whether there is a need to consider sex-specific effects when evaluating genetic risk in clinical prediction models for IPF...
January 15, 2024: medRxiv