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https://www.readbyqxmd.com/read/28918369/the-development-of-biodiversity-conservation-measures-in-china-s-hydro-projects-a-review
#1
REVIEW
Ruiqiao Bai, Xuehua Liu, Xiaofei Liu, Lanmei Liu, Jianping Wang, Sihui Liao, Annah Zhu, Zhouyuan Li
The hydropower capacity of China ranks first in the world and accounts for approximately 20% of the total energy production in the country. While hydropower has substantially contributed to meeting China's renewable energy targets and providing clean energy to rural areas, the development of hydropower in China has been met with significant controversy. Ecologically, hydro projects alter the landscape, with potential impacts to the country's aquatic biodiversity. Over the past four decades in China, various mainstream opinions and misunderstandings have been presented concerning how to alleviate the negative impacts of hydro projects on aquatic ecosystems...
September 14, 2017: Environment International
https://www.readbyqxmd.com/read/28918078/assessment-of-environmental-impacts-and-operational-costs-of-the-implementation-of-an-innovative-source-separated-urine-treatment
#2
Elorri Igos, Mathilde Besson, Tomás Navarrete Gutiérrez, Ana Barbara Bisinella de Faria, Enrico Benetto, Ligia Barna, Aras Ahmadi, Mathieu Spérandio
Innovative treatment technologies and management methods are necessary to valorise the constituents of wastewater, in particular nutrients from urine (highly concentrated and can have significant impacts related to artificial fertilizer production). The FP7 project, ValuefromUrine, proposed a new two-step process (called VFU) based on struvite precipitation and microbial electrolysis cell (MEC) to recover ammonia, which is further transformed into ammonium sulphate. The environmental and economic impacts of its prospective implementation in the Netherlands were evaluated based on life cycle assessment (LCA) methodology and operational costs...
September 8, 2017: Water Research
https://www.readbyqxmd.com/read/28918016/therapeutic-mirna-and-sirna-moving-from-bench-to-clinic-as-next-generation-medicine
#3
REVIEW
Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C George Priya Doss, Sang-Soo Lee
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are some of the most important biopharmaceuticals that are in commercial space as future medicines. This review summarizes the patents of miRNA- and siRNA-based new drugs, and also provides a snapshot about significant biopharmaceutical companies that are investing for the therapeutic development of miRNA and siRNA molecules. An insightful view about individual siRNA and miRNA drugs has been depicted with their present status, which is gaining attention in the therapeutic landscape...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917950/suicide-behavior-and-associated-psychosocial-factors-among-adolescents-in-campeche-mexico
#4
Catalina González-Forteza, Carlos E Juárez-López, Alberto Jiménez, Liliana Montejo-León, Ulises R Rodríguez-Santisbón, Fernando A Wagner
Suicide is an important public health problem that requires a preventive approach. The present study aimed at assessing suicidal behaviors and their relations with other psychosocial factors in Campeche, Mexico, in order to inform the design of potential preventive interventions. A multistage probability sample of 2386 students representative of all middle schools of the state of Campeche, Mexico, took a standardized, paper-and-pencil survey covering selected psychosocial constructs including suicide behavior, depression, drug use, familial relationships, locus of control, impulsivity, and self-esteem, among others...
September 13, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28917776/apta-nanosensors-for-detection-and-quantitative-determination-of-acetamiprid-a-pesticide-residue-in-food-and-environment
#5
REVIEW
Asma Verdian
In an effort to achieve high sensitive and selective detection of pesticide residues, numerous nanomaterial-based aptasensors are currently being developed for acetamiprid analysis. Recently, aptamers as a potent alternative of antibodies are used in biosensing platforms. There is tremendous interest in utilizing of nanomaterial as basic building blocks and signaling elements in aptasensors. The nanomaterials have the unique optical and electrical properties. The combination of nanomaterial and aptamer technology has opened a new window in pesticide residues monitoring...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917733/stabilization-of-gas-phase-uranyl-complexes-enables-rapid-speciation-using-electrospray-ionization-and-ion-mobility-mass-spectrometry
#6
Austen L Davis, Brian H Clowers
Significant challenges exist when characterizing f-element complexes in solution using traditional approaches such as electrochemical and spectroscopic techniques as they do not always capture information for lower abundance species. However, provided a metal-complex with sufficient stability, soft ionization techniques such as electrospray offer a means to quantify and probe the characteristics of such systems using mass spectrometry. Unfortunately, the gas-phase species observed in ESI-MS systems do not always reflect the solution phase distributions due to the inherent electrochemical mechanism of the electrospray process, ion transfer from ambient to low pressures conditions, and other factors that are related to droplet evaporation...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917505/association-of-self-reported-discrimination-and-suicide-ideation-in-older-chinese-americans
#7
Lydia W Li, Gilbert C Gee, XinQi Dong
OBJECTIVE: This study examines racial discrimination as a potential novel risk factor for suicide ideation among older Chinese Americans. DESIGN: In a cross-sectional analysis, this study drew on data collected in the Population-based Study of Chinese Elderly in Chicago on Chinese older adults age 60 + in the Greater Chicago area (N = 3,157). Thirty-day suicide ideation was a dichotomous variable, derived from items of the Physical Health Questionnaire and the Geriatric Mental State Examination-Version A...
August 17, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28917299/exploitation-of-chemical-herbal-and-nanoformulated-acaricides-to-control-the-cattle-tick-rhipicephalus-boophilus-microplus-a-review
#8
REVIEW
Balan Banumathi, Baskaralingam Vaseeharan, Periyannan Rajasekar, Narayanan Marimuthu Prabhu, Palaniappan Ramasamy, Kadarkarai Murugan, Angelo Canale, Giovanni Benelli
The tick Rhipicephalus (Boophilus) microplus is a key vector of bacterial and protozoan diseases causing heavy economic losses directly and indirectly in animal husbandry. In the past decades, the control of ticks faced some major issues, such as the rapid development of resistance in targeted vectors and non-target effects on human health and the environment, due to the employ of synthetic acaricides and repellents. Eco-friendly pesticides for treating and controlling animal parasites such as ticks were mainly from medicinal plants and thus they form the richest entity for manufacturing resources for drugs...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917266/urinary-biomarkers-in-prostate-cancer-detection-and-monitoring-progression
#9
REVIEW
Duojia Wu, Jie Ni, Julia Beretov, Paul Cozzi, Mark Willcox, Valerie Wasinger, Bradley Walsh, Peter Graham, Yong Li
Prostate cancer (CaP) is the most common cancer in men and the second leading cause of cancer deaths in males in Australia. Although serum prostate-specific antigen (PSA) has been the most widely used biomarker in CaP detection for decades, PSA screening has limitations such as low specificity and potential association with over-diagnosis. Current biomarkers used in the clinic are not useful for the early detection of CaP, or monitoring its progression, and have limited value in predicting response to treatment...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28916898/a-strengths-based-case-management-intervention-to-reduce-hiv-viral-load-among-people-who-use-drugs
#10
Alex H Kral, Barrot H Lambdin, Megan Comfort, Christina Powers, Helen Cheng, Andrea M Lopez, Robert O Murdoch, Torsten B Neilands, Jennifer Lorvick
Engaging highly marginalized HIV positive people in sustained medical care is vital for optimized health and prevention efforts. Prior studies have found that strengths-based case management helps link people who use drugs to HIV care. We conducted a pilot to assess whether a strengths-based case management intervention may help people who use injection drugs (PWID) or smoke crack cocaine (PWSC) achieve undetectable HIV viral load. PWID and PWSC were recruited in Oakland, California using targeted sampling methods and referral from jails and were tested for HIV...
September 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28916818/identification-of-4-phenylquinolin-2-1h-one-as-a-specific-allosteric-inhibitor-of-akt
#11
Bill X Huang, Kenny Newcomer, Karl Kevala, Elena Barnaeva, Wei Zheng, Xin Hu, Samarjit Patnaik, Noel Southall, Juan Marugan, Marc Ferrer, Hee-Yong Kim
Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of its inhibitory mechanism. Out of 373,868 compounds screened, 4-phenylquinolin-2(1H)-one specifically decreased Akt phosphorylation at both T308 and S473, and inhibited Akt kinase activity (IC50 = 6 µM) and downstream signaling...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916507/cardiac-patients-experiences-and-perceptions-of-social-media-mixed-methods-study
#12
Stephanie R Partridge, Anne C Grunseit, Patrick Gallagher, Becky Freeman, Blythe J O'Hara, Lis Neubeck, Sarah Due, Glenn Paull, Ding Ding, Adrian Bauman, Philayrath Phongsavan, Kellie Roach, Leonie Sadler, Helen Glinatsis, Robyn Gallagher
BACKGROUND: Traditional in-person cardiac rehabilitation has substantial benefits for cardiac patients, which are offset by poor attendance. The rapid increase in social media use in older adults provides an opportunity to reach patients who are eligible for cardiac rehabilitation but unable to attend traditional face-to-face groups. However, there is a paucity of research on cardiac patients' experiences and perspectives on using social media to support their health. OBJECTIVE: The aim of this study was to describe cardiac rehabilitation patients' experiences in using social media in general and their perspective on using social media, particularly Facebook, to support their cardiac health and secondary prevention efforts...
September 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28916448/molecular-and-synaptic-mechanisms-regulating-drug-associated-memories-towards-a-bidirectional-treatment-strategy
#13
REVIEW
Matthew T Rich, Mary M Torregrossa
The successful treatment of substance use disorders is dependent on the establishment of a long-term abstinent state. Relapse can be suppressed by interfering with memories of drug use that are evoked by re-exposure to drug-associated contexts and cues. Two strategies for accomplishing this goal are either to prevent drug-memory reconsolidation or to induce the formation of a competing, extinction memory. However, clinical attempts to prolong abstinence by behavioral modification of drug-related memories have had limited success...
September 12, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28916391/zika-virus-structural-biology-and-progress-in-vaccine-development
#14
REVIEW
Hsiao-Han Lin, Bak-Sau Yip, Li-Min Huang, Suh-Chin Wu
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the threat to pregnant women. Instances of microcephaly and central nervous system malformations continue to increase in ZIKV outbreak regions. ZIKV is a small enveloped positive-strand RNA virus belonging to the Flavivirus genus of the Flaviviridae family. High-resolution ZIKV structures recently identified by cryo-electron microscopy indicate that the overall ZIKV structure is similar to those of other flaviviruses...
September 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28916250/successful-integration-of-pediatrics-into-state-health-care-reform-efforts
#15
Judith S Shaw, Susan E Varni, Elizabeth Cheng Tolmie, Mary Kate Mohlman, Valerie S Harder
Health care reform in Vermont promotes patient-centered medical homes (PCMH) and multi-disciplinary community health teams to support population health. This qualitative study describes the expansion of Vermont's health care reform efforts, initially focused on adult primary care, to pediatrics through interviews with project managers and facilitators, CHT members, pediatric practitioners and care coordinators, and community-based providers. Analyses used grounded theory, identifying themes confirmed by repeat occurrence across respondents...
September 12, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28916228/cellular-therapy-injections-in-today-s-orthopedic-market-a-social-media-analysis
#16
Prem N Ramkumar, Sergio M Navarro, Heather S Haeberle, Morad Chughtai, Christopher Demetriades, Nicolas S Piuzzi, Michael A Mont, Thomas W Bauer, George F Muschler
BACKGROUND: The current state of cellular therapy for musculoskeletal conditions is at a crossroads. Marketing efforts are often outpacing clinical evidence and regulatory control. QUESTIONS/PURPOSES: This study was an effort to describe the marketing of cellular therapy in musculoskeletal medicine by evaluating the content in popular social media channels. Specifically, media posts were evaluated for the following: (1) perspective, (2) tone, (3) content and (4) visibility...
September 12, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28916222/estimating-vocal-effort-from-the-aerodynamics-of-labial-fricatives-a-feasibility-study
#17
Yohann Meynadier, Anita El Hajj, Michel Pitermann, Thierry Legou, Antoine Giovanni
OBJECTIVE AND HYPOTHESIS: Vocal effort in loud voice is produced with increased subglottal pressure during vowels and increased supraglottal pressure during consonants. In the paper, our main objective is to check whether it was supported by a parallel increase in the airflow resistance of the laryngeal articulator and of the supralaryngeal articulator, here the lips. STUDY DESIGN AND METHOD: For this comparison, our choice fell on the fricative consonants, as their production allows perfectly synchronous air pressure and airflow measurements...
September 12, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28915988/learning-to-be-gendered-gender-socialization-in-early-adolescence-among-urban-poor-in-delhi-india-and-shanghai-china
#18
Sharmistha Basu, Xiayun Zuo, Chaohua Lou, Rajib Acharya, Rebecka Lundgren
PURPOSE: The purpose of the study is to understand the gender socialization process in early adolescence. METHODS: The study was located in two disadvantaged urban communities in Delhi, India and Shanghai, China and was part of the multicountry (15) Global Early Adolescent Study. Qualitative methodologies were used with boys and girls aged 11-13 years, including 16 group-based timeline exercises and 65 narrative interviews. In addition, 58 parents of participating adolescents were interviewed...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915964/decreased-use-of-spatial-pattern-separation-in-contemporary-lifestyles-may-contribute-to-hippocampal-atrophy-and-diminish-mental-health
#19
Lindy Birkel
The spatial pattern separation process has not yet been proposed as a pivotal neural activity affecting hippocampal volume, a metric of mental health. The dentate gyrus/CA3 region is increasingly implicated in hippocampal atrophy, its putative role in spatial pattern separation appears to be impaired in mental health disorders, and performance on a task indicative of pattern separation correlates with dentate gyrus/CA3 volume. Spatial pattern separation is thought to utilize the heightened neural plasticity of newborn neurons in the dentate gyrus to distinguish highly similar aspects of scene so that these remain distinct in memory rather than lost...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915945/potentiometric-sensor-for-non-invasive-lactate-determination-in-human-sweat
#20
Massimo Onor, Stefano Gufoni, Tommaso Lomonaco, Silvia Ghimenti, Pietro Salvo, Fiodor Sorrentino, Emilia Bramanti
The present work describes a non invasive lactate sensing in sweat during workout. The sensing system is based on a non-equilibrium potentiometric measure performed using disposable, chemically modified, screen printed carbon electrodes (SPCEs) that can be wetted with sweat during the exercise. The potentiometric signal, which is proportional to lactate concentration in sweat, is produced by a redox reaction activated by UV radiation, as opposed to the enzymatic reaction employed in traditional, blood-based measuring devices...
October 9, 2017: Analytica Chimica Acta
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