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https://www.readbyqxmd.com/read/27933717/mass-cytometry-analytical-approaches-reveal-cytokine-induced-changes-in-natural-killer-cells
#1
Elena Vendrame, Julia Fukuyama, Dara M Strauss-Albee, Susan Holmes, Catherine A Blish
BACKGROUND: Natural killer (NK) cells have antiviral and antitumor activity that could be harnessed for the treatment of infections and malignancies. To maintain cell viability and enhance antiviral and antitumor effects, NK cells are frequently treated with cytokines. Here we performed an extensive assessment of the effects of cytokines on the phenotype and function of human NK cells. METHODS: We used cytometry by time-of-flight (CyTOF) to evaluate NK cell repertoire changes after stimulation with interleukin (IL)-2, IL-15 or a combination of IL- 12/IL-15/IL-18...
December 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27933436/emerging-biotechnologies-for-production-of-itaconic-acid-and-its-applications-as-a-platform-chemical
#2
REVIEW
Badal C Saha
Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L(-1)) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L(-1)). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A...
December 8, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27933408/twelve-weeks-progressive-resistance-training-combined-with-protein-supplementation-beyond-habitual-intakes-increases-upper-leg-lean-tissue-mass-muscle-strength-and-extended-gait-speed-in-healthy-older-women
#3
Peter Francis, William Mc Cormack, Clodagh Toomey, Catherine Norton, Jean Saunders, Emmet Kerin, Mark Lyons, Philip Jakeman
The age-related decline in functional capability is preceded by a reduction in muscle quality. The purpose of this study was to assess the combined effects of progressive resistance training (PRT) and protein supplementation beyond habitual intakes on upper leg lean tissue mass (LTM), muscle quality and functional capability in healthy 50-70 years women. In a single-blinded, randomized, controlled design, 57 healthy older women (age 61.1 ± 5.1 years, 1.61 ± 0.65 m, 65.3 ± 15.3 kg) consumed 0.33 g/kg body mass of a milk-based protein matrix (PRO) for 12 weeks...
December 8, 2016: Biogerontology
https://www.readbyqxmd.com/read/27933202/screening-and-management-of-viral-hepatitis-and-hepatocellular-carcinoma-in-mongolia-results-from-a-survey-of-mongolian-physicians-from-all-major-provinces-of-mongolia
#4
Yoona A Kim, Jacqueline Estevez, An Le, Dennis Israelski, Oidov Baatarkhuu, Tserenchimed Sarantuya, Sonom Narantsetseg, Pagbajabyn Nymadawa, Richard H Le, Man-Fung Yuen, Geoffrey Dusheiko, Mario Rizzetto, Mindie H Nguyen
BACKGROUND: According to Globocan, Mongolia has the highest worldwide hepatocellular carcinoma (HCC) incidence (78.1/100 000, 3.5× higher than China). AIMS AND METHODS: We conducted an anonymous survey of physicians from major provinces who attended an educational liver symposium, analysing their demography, practice, knowledge, perceptions and proposed solutions. Multivariate logistic regression was used to estimate OR relating demography and practice factors with higher provider knowledge and improvement...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27933065/current-challenges-and-limitations-in-antibody-based-detection-of-citrullinated-histones
#5
Indira Neeli, Marko Radic
Studies on NETosis demand reliable and convenient markers to monitor the progress of this form of cell death. Because a determining step in the release of nuclear chromatin NETs requires the conversion of arginine residues to citrulline residues in histones by peptidylarginine deiminase, citrullinated histones can provide such a marker. Here, we evaluate antibody reagents for the detection of citrulline residues in histones and observe alarming differences between commercial antisera and mouse and rabbit monoclonal antibodies in their ability to detect their nominal target residues...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27932932/atlas-of-ohio-aquatic-insects-volume-ii-plecoptera
#6
R Edward DeWalt, Scott A Grubbs, Brian J Armitage, Richard W Baumann, Shawn M Clark, Michael J Bolton
BACKGROUND: We provide volume II of a distributional atlas of aquatic insects for the eastern USA state of Ohio. This treatment of stoneflies (Plecoptera) is companion to Armitage et al. (2011) on caddisflies (Trichoptera). We build on a recent analysis of Ohio stonefly diversity patterns based on large drainages (DeWalt et al. 2012), but add 3717 new records to the data set. We base most analyses on the United States Geological Survey Hierarchical Unit Code eight (HUC8) drainage scale...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932583/inhibition-of-hiv-1-gag-membrane-interactions-by-specific-rnas
#7
Gabrielle C Todd, Alice A Duchon, Jingga Inlora, Erik D Olson, Karin Musier-Forsyth, Akira Ono
HIV-1 particle assembly, which occurs at the plasma membrane (PM) of cells, is driven by the viral polyprotein, Gag. Gag recognizes phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], a PM-specific phospholipid, via the highly basic region (HBR) in its N-terminal matrix (MA) domain. The HBR is also known to bind to RNA. We have previously shown using an in vitro liposome binding assay that RNA inhibits Gag binding to membranes that lack PI(4,5)P2. If this RNA block is removed by RNase treatment, Gag can bind non-specifically to other negatively charged membranes...
December 8, 2016: RNA
https://www.readbyqxmd.com/read/27932546/what-can-a-participatory-approach-to-evaluation-contribute-to-the-field-of-integrated-care
#8
Laura Eyre, Michael Farrelly, Martin Marshall
Better integration of care within the health sector and between health and social care is seen in many countries as an essential way of addressing the enduring problems of dwindling resources, changing demographics and unacceptable variation in quality of care. Current research evidence about the effectiveness of integration efforts supports neither the enthusiasm of those promoting and designing integrated care programmes nor the growing efforts of practitioners attempting to integrate care on the ground. In this paper we present a methodological approach, based on the principles of participatory research, that attempts to address this challenge...
December 8, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27932261/does-adding-clinical-data-to-administrative-data-improve-agreement-among-hospital-quality-measures
#9
Amresh D Hanchate, Kelly L Stolzmann, Amy K Rosen, Aaron S Fink, Michael Shwartz, Arlene S Ash, Hassen Abdulkerim, Mary Jo V Pugh, Priti Shokeen, Ann Borzecki
BACKGROUND: Hospital performance measures based on patient mortality and readmission have indicated modest rates of agreement. We examined if combining clinical data on laboratory tests and vital signs with administrative data leads to improved agreement with each other, and with other measures of hospital performance in the nation's largest integrated health care system. METHODS: We used patient-level administrative and clinical data, and hospital-level data on quality indicators, for 2007-2010 from the Veterans Health Administration (VA)...
December 5, 2016: Healthcare
https://www.readbyqxmd.com/read/27932213/relating-hydraulic-conductivity-and-hyporheic-zone-biogeochemical-processing-to-conserve-and-restore-river-ecosystem-services
#10
Clara Mendoza-Lera, Thibault Datry
River management practices commonly attempt to improve habitat and ecological functioning (e.g. biogeochemical processing or retention of pollutants) by restoring hydrological exchange with the hyporheic zone (i.e. hyporheic flow) in an effort to increase mass transfer of solutes (nutrients, carbon and electron acceptors such as oxygen or nitrate). However, even when hyporheic flow is increased, often no significant changes in biogeochemical processing are detected. Some of these apparent paradox result from the simplistic assumption that there is a direct relationship between hyporheic flow and biogeochemical processing...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27931937/influence-of-capillary-barrier-effect-on-biogas-distribution-at-the-base-of-passive-methane-oxidation-biosystems-parametric-study
#11
Bahar Ahoughalandari, Alexandre R Cabral
The efficiency of methane oxidation in passive methane oxidation biosystems (PMOBs) is influenced by, among other things, the intensity and distribution of the CH4 loading at the base of the methane oxidation layer (MOL). Both the intensity and distribution are affected by the capillary barrier that results from the superposition of the two materials constituting the PMOB, namely the MOL and the gas distribution layer (GDL). The effect of capillary barriers on the unsaturated flow of water has been well documented in the literature...
December 5, 2016: Waste Management
https://www.readbyqxmd.com/read/27931897/is-suicide-reporting-in-indian-newspapers-responsible-a-study-from-rajasthan
#12
Nikhil Jain, Sunil Kumar
PURPOSE: Media reporting has consistently been shown to influence suicidal behaviour. Irresponsible reporting by the media can lead to imitative suicidal behaviour. The WHO has delineated guidelines for responsible media reporting of suicide. The study aims to examine whether Indian newspapers adhere to the WHO guidelines and whether there are differences in style of reporting between local and national newspapers and between English and Hindi newspapers. METHODS: The study was conducted on ten newspaper publications that were circulated in Jaipur, India from 1st October 2014 to 31st December 2014...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931835/management-of-patients-with-recurrent-advanced-cervical-cancer-beyond-first-line-platinum-regimens-where-do-we-stand-a-literature-review
#13
REVIEW
Stergios Boussios, Esmeralda Seraj, George Zarkavelis, Dimitrios Petrakis, Aristomenes Kollas, Aikaterini Kafantari, Abraam Assi, Konstantina Tatsi, Nicholas Pavlidis, George Pentheroudakis
BACKGROUND: Cervical cancer is the fourth most common cancer affecting women worldwide. Despite advances in screening and human papillomavirus (HPV) vaccination, a significant number of women present with or develop advanced disease. Palliative platinum-based chemotherapy (CT) is the standard first-line treatment for metastatic/recurrent cervical cancer. The prognosis remains poor and effective second line options are urgently needed. METHODS: We searched the English-language medical literature as well as relevant guideline databases, published from January 1981 to December 2015 and identified publications related to cervical cancer and its therapies...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27931466/evidence-based-clinical-practice-guideline-for-the-use-of-pit-and-fissure-sealants
#14
(no author information available yet)
BACKGROUND: This article presents evidence-based clinical recommendations for the use of pit-and-fissure sealants on the occlusal surfaces of primary and permanent molars in children and adolescents. A guideline panel convened by the American Dental Association (ADA) Council on Scientific Affairs and the American Academy of Pediatric Dentistry conducted a systematic review and formulated recommendations to address clinical questions in relation to the efficacy, retention, and potential side effects of sealants to prevent dental caries; their efficacy compared with fluoride varnishes; and a head-to-head comparison of the different types of sealant material used to prevent caries on pits-and-fissures of occlusal surfaces...
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931395/urban-stormwater-characterization-control-and-treatment
#15
Jason R Vogel, Trisha L Moore
The following review presents a synthesis of 181 journal articles published during 2015 that represent progress toward better characterizing, controlling, and treating urban stormwater runoff. The review is structured by general topical areas related to (1) stormwater quality and quantity characterization; (2) engineered stormwater control and treatment practices, including erosion and sediment control, stormwater ponds, constructed stormwater wetlands, bioretention, permeable pavement, greenroofs, and rainwater harvesting systems; and (3) watershed-scale modeling and optimization of stormwater control and treatment practices...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27931268/an-epidemiological-analysis-of-equine-welfare-data-from-regulatory-inspections-by-the-official-competent-authorities
#16
P L Hitchens, J Hultgren, J Frössling, U Emanuelson, L J Keeling
Determining welfare status in a population is the first step in efforts to improve welfare. The primary objective of this study was to explore a new epidemiological approach for analysis of data from official competent authorities that pertain to compliance with animal welfare legislation. We reviewed data already routinely collected as part of Swedish official animal welfare inspections for 2010-13, using a checklist containing 45 checkpoints (CPs). These covered animal-, resource- and management-based measures of equine welfare...
December 9, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27930740/facilitators-and-barriers-of-antiretroviral-therapy-initiation-among-hiv-discordant-couples-in-kenya-qualitative-insights-from-a-pre-exposure-prophylaxis-implementation-study
#17
Rena C Patel, Josephine Odoyo, Keerthana Anand, Gaelen Stanford-Moore, Imeldah Wakhungu, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown
INTRODUCTION: The World Health Organization now recommends antiretroviral therapy (ART) initiation for all HIV-infected individuals regardless of CD4 cell count or disease status. Understanding the facilitators and barriers to initiation of and adherence to ART is essential to successful scale-up of "universal" ART. METHODS: To investigate facilitators and barriers to ART initiation, we conducted 44 in-depth individual or couple interviews with 63 participants (33 participants with HIV and 30 without HIV) already enrolled in a prospective implementation study of oral antiretroviral-based prevention in Kisumu, Kenya between August and September 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27930736/analysis-of-a-smartphone-based-architecture-with-multiple-mobility-sensors-for-fall-detection
#18
Eduardo Casilari, Jose Antonio Santoyo-Ramón, Jose Manuel Cano-García
During the last years, many research efforts have been devoted to the definition of Fall Detection Systems (FDSs) that benefit from the inherent computing, communication and sensing capabilities of smartphones. However, employing a smartphone as the unique sensor in a FDS application entails several disadvantages as long as an accurate characterization of the patient's mobility may force to transport this personal device on an unnatural position. This paper presents a smartphone-based architecture for the automatic detection of falls...
2016: PloS One
https://www.readbyqxmd.com/read/27930672/brain-connectivity-variation-topography-associated-with-working-memory
#19
Xiaofei Ma, Xiaolin Huang, Yun Ge, Yueming Hu, Wei Chen, Aili Liu, Hongxing Liu, Ying Chen, Bin Li, Xinbao Ning
Brain connectivity analysis plays an essential role in the research of working memory that involves complex coordination of various brain regions. In this research, we present a comprehensive view of trans-states brain connectivity variation based on continuous scalp EEG, extending beyond traditional stimuli-lock averaging or restriction to short time scales of hundreds of milliseconds after stimulus onset. The scalp EEG was collected under three conditions: quiet, memory, and control. The only difference between the memory and control conditions was that in the memory condition, subjects made an effort to retain information...
2016: PloS One
https://www.readbyqxmd.com/read/27930485/results-from-the-bipartisan-policy-center-s-ceo-council-physical-activity-challenge-to-american-business
#20
Jeff Berko, Ron Z Goetzel, Enid Chung Roemer, Karen Kent, Janet Marchibroda
OBJECTIVE: The aim of this study was to describe findings from a survey of employees at 10 businesses participating in the "Building Better Health: Physical Activity Challenge," an effort led by the Bipartisan Policy Center's CEO Council on Health and Innovation. METHODS: Employers provided employees with pedometers as part of an 8-week Physical Activity Challenge (Challenge). Employees were then asked to complete a survey about their awareness of, participation in, and satisfaction with the Challenge...
December 2016: Journal of Occupational and Environmental Medicine
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