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https://www.readbyqxmd.com/read/28550780/dioxin-in-the-river-elbe
#1
Rainer Götz, Michael Bergemann, Burkhard Stachel, Gunther Umlauf
This paper provides a macro-analysis of the dioxin contamination in the river Elbe from the 1940s to the present. Based on different data sets, the historic dioxin concentration in the Elbe has been reconstructed. For the section between the tributary Mulde and Hamburg, during the 1940s, we find a concentration of about 1500 pg WHO-TEQ g(-1). We argue that this dioxin contamination was caused mainly by emissions from a magnesium plant in Bitterfeld-Wolfen, whose effluents were discharged into a tributary of the river Mulde which flows into the Elbe...
May 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28550703/improving-patient-engagement-and-satisfaction-lessons-from-a-patient-driven-care-initiative-in-a-community-based-hospital
#2
Lisa Shiozaki, Kirsten Burgomaster, Manon Lemonde
Lack of collaboration and alignment between members of the healthcare team interfere with the patient-centred care approach. The Patient-Driven Care Project was initiated in 2012. This model sought to advance a system of care that is patient-driven, family-centred and provider-guided to improve the value to patients and give them more control on their health journey. The evaluation revealed that the efforts should focus on sustainability and continuation of support and encouragement of hospital colleagues to ensure each patient and family experience is based on caring communication at every interaction with them...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550505/neuro-oncology-family-caregivers-view-on-keeping-track-of-care-issues-using-ehealth-systems-it-s-a-question-of-time
#3
Florien W Boele, Cornelia F van Uden-Kraan, Karen Hilverda, Jason Weimer, Heidi S Donovan, Jan Drappatz, Frank S Lieberman, Irma Verdonck-de Leeuw, Paula R Sherwood
Primary brain tumors (PBTs) are rare but have a great impact on both patient and family caregiver wellbeing. Supporting caregivers can help them to continue their caregiving activities to maintain the patients' best possible level of quality of life. Efforts to improve PBT caregiver wellbeing should take into account country- or culture-specific differences in care issues and supportive care needs to serve larger caregiver groups. We aimed to explore PBT caregivers' satisfaction with the current supportive care provision, as well as their thoughts on monitoring their care issues with both paper-based and digital instruments...
May 26, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28550001/more-than-a-text-message-dismantling-digital-triggers-to-curate-behavior-change-in-patient-centered-health-interventions
#4
Frederick Muench, Amit Baumel
Digital triggers such as text messages, emails, and push alerts are designed to focus an individual on a desired goal by prompting an internal or external reaction at the appropriate time. Triggers therefore have an essential role in engaging individuals with digital interventions delivered outside of traditional health care settings, where other events in daily lives and fluctuating motivation to engage in effortful behavior exist. There is an emerging body of literature examining the use of digital triggers for short-term action and longer-term behavior change...
May 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28549980/trends-in-malpractice-claims-for-obstetric-and-gynecologic-procedures-2005-2014
#5
Laura M Glaser, Farah A Alvi, Magdy P Milad
BACKGROUND: Interest in medical malpractice and areas of medico-legal vulnerability for practicing obstetricians and gynecologists has grown substantially, and many providers report changing surgical practice out of fear of litigation. Furthermore, education on medical malpractice and risk management is lacking for obstetrics and gynecology trainees. Recent obstetric and gynecologic malpractice claims data is lacking. We report on recent trends in malpractice claims for obstetrics and gynecology procedures, and compare these trends to those of other medical specialties...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#6
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28549876/prediction-and-analysis-of-promiscuous-t-cell-epitopes-derived-from-the-vaccine-candidate-antigens-of-leishmania-donovani-binding-to-mhc-class-ii-alleles-using-in-silico-approach
#7
Manju Kashyap, Varun Jaiswal, Umar Farooq
Visceral leishmaniasis is a dreadful infectious disease and caused by the intracellular protozoan parasites, Leishmania donovani and Leishmania infantum. Despite extensive efforts for developing effective prophylactic vaccine, still no vaccine is available against leishmaniasis. However, advancement in immunoinformatics methods generated new dimension in peptide based vaccine development. The present study was aimed to identify T-cell epitopes from the vaccine candidate antigens like Lipophosphogylcan-3(LPG-3) and Nucleoside hydrolase (NH) from the L...
May 23, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28549864/hyaluronan-hydrogels-with-a-low-degree-of-modification-as-scaffolds-for-cartilage-engineering
#8
Annalisa La Gatta, Giulia Ricci, Antonietta Stellavato, Marcella Cammarota, Rosanna Filosa, Agata Papa, Antonella D'Agostino, Marianna Portaccio, Ines Delfino, Mario De Rosa, Chiara Schiraldi
In the field of cartilage engineering, continuing efforts have focused on fabricating scaffolds that favor maintenance of the chondrocytic phenotype and matrix formation, in addition to providing a permeable, hydrated, microporous structure and mechanical support. The potential of hyaluronan-based hydrogels has been well established, but the ideal matrix remains to be developed. This study describes the development of hyaluronan sponges-based scaffolds obtained by lysine methyl-ester crosslinking. The reaction conditions are optimized with minimal chemical modifications to obtain materials that closely resemble elements in physiological cellular environments...
May 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28549856/three-decades-of-managing-tomato-spotted-wilt-virus-in-peanut-in-southeastern-united-states
#9
REVIEW
R Srinivasan, M R Abney, A K Culbreath, R C Kemerait, R S Tubbs, W S Monfort, H R Pappu
Southeastern states namely Georgia, Florida, and Alabama produce two-thirds of the peanuts in the United States. Thrips-transmitted Tomato spotted wilt virus (TSWV), which causes spotted wilt disease, has been a major impediment to peanut production for the past three decades. The cultivars grown in the 1980s were extremely susceptible to TSWV. Early yield losses extended to tens of millions of dollars each year (up to 100% loss in many fields). This situation led to the creation of an interdisciplinary team known as "SWAT: Spotted Wilt Action Team"...
May 23, 2017: Virus Research
https://www.readbyqxmd.com/read/28549854/an-empirical-review-of-antimalarial-quality-field-surveys-the-importance-of-characterising-outcomes
#10
REVIEW
James Grech, James Robertson, Jackson Thomas, Gabrielle Cooper, Mark Naunton, Tamsin Kelly
For decades, thousands of people have been dying from malaria infections because of poor-quality medicines (PQMs). While numerous efforts have been initiated to reduce their presence, PQMs are still risking the lives of those seeking treatment. This review addresses the importance of characterising results of antimalarial medicine field surveys based upon the agreement of clearly defined definitions. Medicines found to be of poor quality can be falsified or counterfeit, substandard or degraded. The distinction between these categories is important as each category requires a different countermeasure...
May 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28549706/long-term-effectiveness-of-a-multifactorial-fall-and-fracture-prevention-program-in-bavarian-nursing-homes-an-analysis-based-on-health-insurance-claims-data
#11
Claudia Schulz, Ivonne Lindlbauer, Kilian Rapp, Clemens Becker, Hans-Helmut König
OBJECTIVE: Femoral fractures are frequently consequences of falls in nursing homes and are associated with considerable costs and unfavorable outcomes such as immobility and mortality. The purpose of this study was to examine the long-term effectiveness of a multifactorial fall and fracture prevention program in nursing homes in terms of reducing femoral fractures. DESIGN: Retrospective cohort study. SETTING: Nursing homes. PARTICIPANTS: Health insurance claims data for 2005-2013 including 85,148 insurants of a sickness fund (Allgemeine Ortskrankenkasse Bayern), aged 65 years or older and living in 802 nursing homes in Bavaria, Germany...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549431/insecticide-treated-nets-provide-protection-against-malaria-to-children-in-an-area-of-insecticide-resistance-in-southern-benin
#12
John Bradley, Aurore Ogouyèmi-Hounto, Sylvie Cornélie, Jacob Fassinou, Yolande Sissinto Savi de Tove, Adicath Adéola Adéothy, Filémon T Tokponnon, Patrick Makoutode, Alioun Adechoubou, Thibaut Legba, Telesphore Houansou, Dorothée Kinde-Gazard, Martin C Akogbeto, Achille Massougbodji, Tessa Bellamy Knox, Martin Donnelly, Immo Kleinschmidt
BACKGROUND: Malaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa. METHODS: In 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children. RESULTS: Children who used LLINs had lower levels of malaria infection [odds ratio = 0...
May 26, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28549270/the-effects-of-early-life-adversity-on-the-immune-system
#13
REVIEW
Martha M C Elwenspoek, Annette Kuehn, Claude P Muller, Jonathan D Turner
Early life adversity (ELA) is associated with a higher risk for diseases in adulthood. Although the pathophysiological effects of ELA are varied, there may be a unifying role for the immune system in all of the long-term pathologies such as chronic inflammatory disorders (autoimmune diseases, allergy, and asthma). Recently, significant efforts have been made to elucidate the long-term effects ELA has on immune function, as well as the mechanisms underlying these immune changes. In this review, we focus on data from human studies investigating immune parameters in relation to post-natal adverse experiences...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28549142/how-do-performance-based-financing-programmes-measure-quality-of-care-a-descriptive-analysis-of-68-quality-checklists-from-28-low-and-middle-income-countries
#14
Erik Josephson, Jessica Gergen, Martha Coe, Samantha Ski, Supriya Madhavan, Sebastian Bauhoff
This paper seeks to systematically describe the length and content of quality checklists used in performance-based financing programmes, their similarities and differences, and how checklists have evolved over time. We compiled a list of supply-side, health facility-based performance-based financing (PBF) programmes in low- and lower middle-income countries based on a document review. We then solicited PBF manuals and quality checklists from implementers and donors of these PBF mechanisms. We entered each indicator from each quality checklist into a database verbatim in English, and translated into English from French where appropriate, and categorized each indicator according to the Donabedian framework and an author-derived categorization...
May 26, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28549120/dementia-capable-care-coordination-in-duals-demonstration-programs-workforce-needs-promising-practices-and-policy
#15
Brooke Hollister, Jason D Flatt, Susan A Chapman
Background and Objectives: This study describes the program requirements, workforce competencies, and barriers for dementia capable care coordination within health plans from seven states participating in the Center for Medicare and Medicaid Services demonstration programs for dually-eligible Medicare and Medicaid beneficiaries. Research Design and Methods: Data came from contracts, policy documents, and 24 semistructured key informant interviews with national experts and leaders from community-based organizations, advocacy organizations, researchers, federal and state government, and health plans in the seven states...
May 25, 2017: Gerontologist
https://www.readbyqxmd.com/read/28548703/microsporidians-xenomas-of-anglerfish-from-ne-atlantic-waters
#16
M Llarena-Reino, E Abollo, S Pascual
The presence of emergent visible parasites at commercial valuable fish species is increasingly causing problems at fisheries and seafood industries. Microsporidians have been previously reported to appear forming apparent xenomas complexes in anglerfish species, but no effort has been carried out to simultaneously integrate epidemiological data, phenotypic, genotypic and fine structural characterizations in the same parasite sample. In this work, specimens of Lophius budegassa and Lophius piscatorius from NE Atlantic waters were sampled and examined to provide information about specific site of infection and demographic data of two groups of different sizes of xenomas present at both fish species...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28548390/a-step-towards-removing-plasma-volume-variance-from-the-athlete-s-biological-passport-the-use-of-biomarkers-to-describe-vascular-volumes-from-a-simple-blood-test
#17
Louisa M Lobigs, Pierre-Edouard Sottas, Pitre C Bourdon, Zoran Nikolovski, Mohamed El-Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O Schumacher
The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers. Our laboratory recently identified a panel of common chemistry markers (from a simple blood test) capable of describing ~67% of PV variance, presenting an applicable method to account for volume shifts within antidoping practices...
May 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28548103/an-aavp-based-solid-phase-transducing-matrix-for-transgene-delivery-potential-for-translational-applications
#18
T L Smith, G R Souza, R L Sidman, W Arap, R Pasqualini
A hybrid vector of adeno-associated virus and phage (termed AAVP) has been introduced as a platform for systemic ligand-directed delivery of transgenes to tumors over the past decade. A series of studies have evaluated the AAVP platform for potential theranostic or purely therapeutic applications in several tumor models. Sufficient ligand-directed tumor targeting consistently resulted in specific molecular-genetic imaging and/or anti-tumor responses to 'suicide' transgene delivery. However, efforts to optimize transduction efficiency are still ongoing...
May 26, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28547033/assessing-colorectal-cancer-knowledge-among-puerto-rican-hispanics-implications-for-cancer-prevention-and-control
#19
Reinaldo Ramírez-Amill, Marievelisse Soto-Salgado, Carla Vázquez-Santos, Mónica Corzo-Pedrosa, Marcia Cruz-Correa
In Puerto Rico, colorectal cancer (CRC) incidence and mortality rates are increasing. Moreover, adherence rates to CRC screening (52.2%) are still below the goals (70.5%) established by Healthy People 2020. Lack of knowledge is described as a significant barrier to adherence to CRC screening. The aim of this study was to assess CRC knowledge and screening rates among Puerto Rican Hispanics. Participants aged 40-85 years were recruited from the internal medicine outpatient clinics at the University of Puerto Rico...
May 25, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28546055/the-long-way-of-implementing-patient-centered-care-and-shared-decision-making-in-germany
#20
Martin Härter, Jörg Dirmaier, Isabelle Scholl, Norbert Donner-Banzhoff, Marie-Luise Dierks, Wolfgang Eich, Hardy Müller, David Klemperer, Klaus Koch, Christiane Bieber
The main focus of the paper is on the description of the development and current state of research and implementation of patient-centered care (PCC) and shared decision-making (SDM) after fifteen years of substantial advances in health policy and health services research. What is the current state of SDM in health policy? The "Law on Patients' Rights" from 2013 standardizes all rights and responsibilities within the framework of medical treatment for German citizens and legal residents. This comprises the right to informed decisions, comprehensive and comprehensible information for patients, and decisions based on a clinician-patient-partnership...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
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