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https://www.readbyqxmd.com/read/29748936/semi-quantitative-dopamine-transporter-standardized-uptake-value-in-comparison-with-conventional-specific-binding-ratio-in-123i-fp-cit-single-photon-emission-computed-tomography-datscan
#1
Yuichi Wakabayashi, Ryuichi Takahashi, Tomonori Kanda, Feibi Zeng, Munenobu Nogami, Kazunari Ishii, Takamichi Murakami
PURPOSE: We developed a new analytical method to quantify the dopamine transporter (DAT) radiation dose in the striatum on [123 I] FP-CIT single-photon emission computed tomography (SPECT). This method is based on the dopamine transporter standardized uptake value (DaTSUV). The purpose of this study was to compare DaTSUV with the classical specific binding ratio (SBR) in the discrimination of dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. METHOD: Seventy-seven consecutive patients who underwent DaTscan were included...
May 10, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29713303/association-between-peripheral-inflammation-and-datscan-data-of-the-striatal-nuclei-in-different-motor-subtypes-of-parkinson-disease
#2
Hossein Sanjari Moghaddam, Farzaneh Ghazi Sherbaf, Mahtab Mojtahed Zadeh, Amir Ashraf-Ganjouei, Mohammad Hadi Aarabi
The interplay between peripheral and central inflammation has a significant role in dopaminergic neural death in nigrostriatal pathway, although no direct assessment of inflammation has been performed in relation to dopaminergic neuronal loss in striatal nuclei. In this study, the correlation of neutrophil to lymphocyte ratio (NLR) as a marker of peripheral inflammation to striatal binding ratios (SBRs) of DAT SPECT images in bilateral caudate and putamen nuclei was calculated in 388 drug-naïve early PD patients [288 tremor dominant (TD), 73 postural instability and gait difficulty (PIGD), and 27 indeterminate] and 148 controls...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29406893/dopamine-transporter-imaging-predicts-motor-responsiveness-to-levodopa-challenge-in-patients-with-parkinson-s-disease-a-pilot-study-of-datscan-for-subthalamic-deep-brain-stimulation
#3
Asuka Nakajima, Yasushi Shimo, Satoko Sekimoto, Koji Kamagata, Takayuki Jo, Genko Oyama, Atsushi Umemura, Nobutaka Hattori
Imaging studies are necessary prior to subthalamic deep brain stimulation (STN-DBS). Dopamine transporter (DAT) imaging is a powerful tool for visualizing dopamine terminals in the striatum, but its usefulness in STN-DBS is unclear. Here, we retrospectively investigated the relationship between motor symptoms and the specific binding ratio (SBR) on DAT imaging in patients with Parkinson's disease (PD). We included 23 consecutive patients (9 female; 14 male) who were evaluated for DBS eligibility between October 2013 and October 2014 and subsequently received bilateral STN-DBS...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29366621/high-resolution-diffusion-tensor-imaging-indicates-asymmetric-microstructural-disorganization-within-substantia-nigra-in-early-parkinson-s-disease
#4
Frauke Knossalla, Zacharias Kohl, Jürgen Winkler, Stefan Schwab, Thomas Schenk, Tobias Engelhorn, Arnd Doerfler, Philipp Gölitz
BACKGROUND AND PURPOSE: Parkinson's disease (PD) is characterised by neuropathological degenerative changes in the substantia nigra (SN). Our study aimed to evaluate whether high-resolution diffusion tensor-imaging (DTI) can detect anatomical biomarkers in early-stage PD, and has the potential to visualize asymmetry effects comparable to the 123I-FP-CIT SPECT (DaTSCAN). METHODS: Ten early-stage PD patients with mild disease severity and ten age- and gender-matched healthy controls were examined with a high-resolution DTI protocol at a 3 Tesla MRI scanner to assess fractional anisotropy (FA) values in the ventral, middle and dorsal region of SN...
April 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29346173/the-subresolution-datscan-phantom-a-cost-effective-flexible-alternative-to-traditional-phantom-technology
#5
Jonathan C Taylor, Nicholas Vennart, Ian Negus, Robin Holmes, Oliver Bandmann, Christine Lo, John Fenner
The Alderson striatal phantom is frequently used to assess I-FP-CIT (Ioflupane) image quality and to test semi-quantification software. However, its design is associated with a number of limitations, in particular: unrealistic image appearances and inflexibility. A new physical phantom approach is proposed on the basis of subresolution phantom technology. The design incorporates thin slabs of attenuating material generated through additive manufacturing, and paper sheets with radioactive ink patterns printed on their surface, created with a conventional inkjet printer...
March 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29247084/protocol-of-a-single-group-prospective-observational-study-on-the-diagnostic-value-of-3t-susceptibility-weighted-mri-of-nigrosome-1-in-patients-with-parkinsonian-symptoms-the-n3-i-pd-study-nigrosomal-i-ron-i-maging-i-n-parkinson-s-disease
#6
Stefan T Schwarz, Yue Xing, Saadnah Naidu, Jim Birchall, Rob Skelly, Alan Perkins, Jonathan Evans, Gill Sare, Antonio Martin-Bastida, Nin Bajaj, Penny Gowland, Paola Piccini, Dorothee P Auer
INTRODUCTION: Parkinson's disease (PD) is the most common movement disorder in the elderly and is characterised clinically by bradykinesia, tremor and rigidity. Diagnosing Parkinson's can be difficult especially in the early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it is unclear whether this may help to establish the diagnosis in the early stages of PD, when there is diagnostic uncertainty. In this scenario, a single photon emission CT scan using a radioactive dopamine transporter ligand can help to establish the diagnosis, or clinical follow-up may eventually clarify the diagnosis...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29164011/dat-s-awesome-hawai-i-s-first-dopamine-transporter-dat-nuclear-medicine-study
#7
Eric J Royston, Yang-En Kao, Kevin M Nakamura
Parkinsonian Syndromes are difficult to accurately diagnose and distinguish from other neurological processes such as essential tremor. Until now, physical exam and clinical presentation have been the gold standard for diagnosis (bradykinesia, tremor, rigidity, and postural instability).1 However, this leads to over- or under diagnosis and improper treatment due to variability in presentation and symptoms.1 A nuclear medicine study using I-123 Ioflupane (DaTSCAN) has been developed, which allows accurate differentiation of Parkinsonian Syndromes from other etiologies...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29131690/investigating-ioflupane-i-123-injection-and-single-photon-emission-tomography-as-an-imaging-biomarker-for-long-term-sequelae-following-mild-traumatic-brain-injury
#8
Nicole Reams, Julie Anderson, Reid Perlman, Wei Li, Shaun Walters, Samuel Tideman, Chi Wang, Kelly Simon, Roberta Frigerio, Demetrius M Maraganore
OBJECTIVE: To determine whether there were differences in clinical outcomes for ioflupane I123 injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI). METHODS: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months)...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29095328/c9orf72-intermediate-repeat-expansion-in-a-patient-with-psychiatric-disorders-and-progressive-cerebellar-ataxia
#9
Mario Meloni, Rita Farris, Paolo Solla, Marcello M Mascia, Francesco Marrosu, Antonino Cannas
INTRODUCTION: Large expansions of the noncoding GGGGCC repeat (more than 30) in the first intron of the C9ORF72 gene have been demonstrated to cause amyotrophic lateral sclerosis and frontotemporal dementia. Recent papers have investigated the possible pathogenic role and associated clinical phenotypes of hexanucleotide expansions with intermediate repeat lengths ranging between 20 and 29 repeats. CASE REPORT: We report a case of a 71-year-old Sardinian female patient with a long history of psychiatric disorders such as mixed anxiety-depressive disorder associated with somatization disorder and histrionic personality who developed a slowly progressive cerebellar syndrome, mild cognitive impairment, pyramidal signs, and rapid eye movement sleep behavior disorder with imaging abnormalities on the DaTSCAN single-photon emission computed tomography indicating an alteration in the presynaptic dopaminergic system...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29082509/combining-olfactory-test-and-motion-analysis-sensors-in-parkinson-s-disease-preclinical-diagnosis-a-pilot-study
#10
C Maremmani, F Cavallo, C Purcaro, G Rossi, S Salvadori, E Rovini, D Esposito, A Pieroni, S Ramat, P Vanni, B Fattori, G Meco
OBJECTIVES: Preclinical diagnosis of Parkinson's disease (PD) is nowadays a topic of interest as the neuropathological process could begin years before the appearance of motor symptoms. Several symptoms, among them hyposmia, could precede motor features in PD. In the preclinical phase of PD, a subclinical reduction in motor skills is highly likely. In this pilot study, we investigate a step-by-step method to achieve preclinical PD diagnosis. MATERIAL AND METHODS: We used the IOIT (Italian Olfactory Identification Test) to screen a population of healthy subjects...
February 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29063467/correlations-between-dopamine-transporter-density-measured-by-123-i-fp-cit-spect-and-regional-gray-matter-volume-in-parkinson-s-disease
#11
Tomoko Maekawa, Noriko Sato, Miho Ota, Atsuhiko Sugiyama, Daichi Sone, Mikako Enokizono, Yukio Kimura, Youhei Mukai, Miho Murata, Harumasa Takano, Etsuko Imabayashi, Hiroshi Matsuda, Akira Kunimatsu, Osamu Abe
PURPOSE: Parkinson's disease (PD) is caused by a selective degeneration of dopamine neurons. The relationship between dopamine transporter (DAT) density and gray matter volume has been unclear. Here we investigated the voxelwise correlation between gray matter volume and DAT binding measured by123 I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (123 I-FP-CIT) single-photon emission computed tomography (SPECT; DaTscan™ imaging) in PD. MATERIALS AND METHODS: Thirty-one male patients with PD were examined with MRI and DaTscan...
December 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28981227/-treatment-of-parkinson-s-disease
#12
S Dethy
Parkinson's disease in a neurodegenerative disorder that affects as many as 1-2 % of persons aged 60 years and older. Parkinson's disease occurs infrequently under 40 years of age, with major genetic implication. Alpha-synuclein plays significant pathogenic role in Parkinson's disease. Therapeutic advances based on a synucleinrelated mechanism are now developed : immunotherapy against alpha-synuclein for example. The diagnosis of Parkinson's disease remains mostly clinical. DatScan® may be helpful to distinguish parkinsonian syndrome and essential tremor...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28926500/occipital-lobe-and-posterior-cingulate-perfusion-in-the-prediction-of-dementia-with-lewy-body-pathology-in-a-clinical-sample
#13
Angus M J Prosser, Livia Tossici-Bolt, Christopher M Kipps
OBJECTIVE: The aim of this study was to investigate the diagnostic value of occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure of analysis. PATIENTS AND METHODS: In total, 99 patients with cognitive complaints who had undergone both technetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography (Tc-HMPAO SPECT) and I ioflupane (I-FP-CIT also called DaTSCAN) imaging in a dementia diagnostic center were analyzed...
December 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28836067/is-nigrostriatal-dopaminergic-deficit-necessary-for-holmes-tremor-to-develop-the-datscan-and-ibzm-spect-study
#14
Agata Gajos, Sławomir Budrewicz, Magdalena Koszewicz, Małgorzata Bieńkiewicz, Janusz Dąbrowski, Jacek Kuśmierek, Jarosław Sławek, Andrzej Bogucki
Holmes's tremor (HT) is assumed to be the result of coexistence of nigrostriatal dopaminergic system impairment and the lesion of cerebello-thalamic pathways. It was suggested that dopaminergic deficiency is responsible for rest tremor, and lack of compensatory cerebellar function leads to spill of tremor into voluntary movements. Cases of HT with and without abnormalities of the presynaptic part of dopaminergic nigrostriatal were published and these findings raised the question of possibility of the postsynaptic lesion...
November 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28743197/evaluation-of-parkinson-s-disease-by-neuromelanin-sensitive-magnetic-resonance-imaging-and-123-i-fp-cit-spect
#15
Keita Kuya, Toshihide Ogawa, Yuki Shinohara, Mana Ishibashi, Shinya Fujii, Naoko Mukuda, Yoshio Tanabe
Background Both neuromelanin-sensitive magnetic resonance imaging (NmMRI) and 123 I-FP-CIT single photon emission computed tomography (SPECT) (DaTSCAN) assist the diagnosis of Parkinson's disease (PD). However, there have been few studies investigating a correlation between them. Purpose To correlate the utility of NmMRI and DaTSCAN and to evaluate the relationship between both imaging findings and the Unified PD rating scale part III (UPDRS III) score for the diagnosis and management of PD. Material and Methods Seventeen patients with PD who underwent both NmMRI and DaTSCAN were included...
May 2018: Acta Radiologica
https://www.readbyqxmd.com/read/28704342/a-novel-compact-small-field-of-view-hybrid-gamma-camera-first-clinical-results
#16
Aik H Ng, Patricia E Blackshaw, Mohammed S Alqahtani, Layal K Jambi, Sarah L Bugby, John E Lees, Alan C Perkins
INTRODUCTION: Hybrid imaging has proven to be a major innovation in nuclear medicine, allowing the fusion of functional information with anatomical detail. In the past, the use of hybrid imaging such as PET-CT, PET-MRI and SPECT-CT has been of great clinical benefit; however, these scanners are relatively large and bulky. We have developed and investigated the clinical application of a compact small field of view hybrid gamma camera (HGC) that is suitable for small-organ imaging at the patient bedside...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28615899/clinical-and-imaging-study-of-isolated-and-mixed-rest-and-action-tremor-essential-tremor-versus-parkinson-s-disease
#17
Sandro Zambito Marsala, Michele Pistacchi, Manuela Gioulis, Franco Ferracci, Livio Capus
BACKGROUND: Some patients present an unusual association of both action tremor (AT) and rest tremor (RT) making the differential diagnosis between essential tremor (ET) and Parkinson's disease (PD) difficult. AIM: To investigate this particular clinical picture trying to focus on possible peculiar clinical inferences. PATIENTS AND METHODS: Twenty-three patients with atypical tremor syndrome were selected for the study. They underwent neurological examination, neuroimaging study, and brain DaTSCAN single-photon emission computed tomography...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28424607/multivariate-analysis-of-18f-dmfp-pet-data-to-assist-the-diagnosis-of-parkinsonism
#18
Fermín Segovia, Juan M Górriz, Javier Ramírez, Francisco J Martínez-Murcia, Johannes Levin, Madeleine Schuberth, Matthias Brendel, Axel Rominger, Kai Bötzel, Gaëtan Garraux, Christophe Phillips
An early and differential diagnosis of parkinsonian syndromes still remains a challenge mainly due to the similarity of their symptoms during the onset of the disease. Recently, 18F-Desmethoxyfallypride (DMFP) has been suggested to increase the diagnostic precision as it is an effective radioligand that allows us to analyze post-synaptic dopamine D2/3 receptors. Nevertheless, the analysis of these data is still poorly covered and its use limited. In order to address this challenge, this paper shows a novel model to automatically distinguish idiopathic parkinsonism from non-idiopathic variants using DMFP data...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28402459/spine-topographical-distribution-of-skin-%C3%AE-synuclein-deposits-in-idiopathic-parkinson-disease
#19
Vincenzo Donadio, Alex Incensi, Giovanni Rizzo, Cesa Scaglione, Sabina Capellari, Enrico Fileccia, Patrizia Avoni, Rocco Liguori
Phosphorylated α-synuclein (p-syn) in skin nerves mainly in the proximal sites is a promising neurodegenerative biomarker for idiopathic Parkinson disease (IPD). However, the p-syn spine distribution particularly in patients with unilateral motor dysfunctions remains undefined. This study aimed to investigate in IPD p-syn differences between left and right cervical spine sites in patients with prevalent unilateral motor symptoms, and cervical and thoracic spine sites in patients with bilateral motor symptoms...
May 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28382589/age-related-effects-and-gender-differences-in-japanese-healthy-controls-for-123-i-fp-cit-spect
#20
Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki
OBJECTIVE: Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of aging and gender on DAT availability in Japanese people. METHODS: SPECT imaging of 30 healthy Japanese controls (17 males, 13 females; range 50-86 years, mean 70 years) was performed...
June 2017: Annals of Nuclear Medicine
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