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https://www.readbyqxmd.com/read/28194630/source-based-morphometry-multivariate-approach-to-analyze-123-i-fp-cit-spect-imaging
#1
Enrico Premi, V D Calhoun, V Garibotto, R Turrone, A Alberici, E Cottini, A Pilotto, S Gazzina, M Magoni, B Paghera, B Borroni, A Padovani
PURPOSE: [(123)I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [(123)I]FP-CIT may be considered for other monoaminergic systems, in particular the serotonin transporter (SERT). Independent component analysis (ICA) implemented in source-based morphometry (SBM) could represent an alternative method to explore monoaminergic pathways, studying the relationship among voxels and grouping them into "neurotransmission" networks...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28130765/-123-i-fp-cit-enc-dat-normal-database-the-impact-of-the-reconstruction-and-quantification-methods
#2
Livia Tossici-Bolt, John C Dickson, Terez Sera, Jan Booij, Susanne Asenbaun-Nan, Maria C Bagnara, Thierry Vander Borght, Cathrine Jonsson, Robin de Nijs, Swen Hesse, Pierre M Koulibaly, Umit O Akdemir, Michel Koole, Klaus Tatsch, Andrea Varrone
BACKGROUND: [(123)I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [(123)I]FP-CIT specific binding ratio (SBR) under optimised protocols for image acquisition and processing. Simpler reconstruction methods, however, are in use in many hospitals, often without implementation of attenuation and scatter corrections...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28120040/is-increased-spinal-nociception-another-hallmark-for-parkinson-s-disease
#3
Evangelia Boura, Maria Stamelou, David Vadasz, Vincent Ries, Marcus M Unger, Georg Kägi, Wolfgang H Oertel, Jens C Möller, Veit Mylius
Augmented spinal nociception during the "off" phase has been observed early in Parkinson's disease further increasing with disease duration. To find out whether increased spinal nociception represents a premotor feature, experimental pain sensitivity was assessed in idiopathic REM-sleep behavior disorder (IRBD) patients with or without signs of a neurodegenerative disorder compared to early Parkinson's disease (ePD) patients and healthy controls (HC). Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in 14 IRBD, 15 ePD patients in the medication-defined "off" state and 27 HC in an explorative cohort study...
January 24, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28040345/imagerie-c%C3%A3-r%C3%A3-brale-dans-les-syndromes-parkinsoniens
#4
Stéphane Prange, Marc Hermier, Teodor Danaila, Chloé Laurencin, Stéphane Thobois
Role of brain imaging for Parkinsonism T brain MRI is normal in Pakinson's disease. Brain MRI is useless when clinical presentation is typical of idiopathic Parkinson's disease. Brain MRI is the exam of choice for differentiating idiopathic Parkinson's disease and atypical parkinsonism. DATscan* confirms or rules out dopaminergic degeneration but does not separate idiopathic Parkinson's disease from Parkinson "plus" syndromes. FDG PET is helpful to separate idiopathic Parkinson's disease from Parkinson "plus" syndromes...
December 28, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27990313/deep-brain-stimulation-of-a-patient-with-psychogenic-movement-disorder
#5
Jean-Philippe Langevin, Jesse M Skoch, Scott J Sherman
BACKGROUND: The long-term safety of deep brain stimulation (DBS) is an important issue because new applications are being investigated for a variety of disorders. Studying instances where DBS was inadvertently implanted in patients without a movement disorder may provide information about the safety of the therapy. We report the case of a patient with a psychogenic movement disorder treated with deep brain stimulation (DBS). CASE DESCRIPTION: The patient presented at our clinic after 5 years of chronic DBS of the subthalamic nucleus (STN) for presumed Parkinson's disease...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27984256/cognition-in-patients-with-a-clinical-diagnosis-of-parkinson-disease-and-scans-without-evidence-of-dopaminergic-deficit-swedd-2-year-follow-up
#6
Kathryn A Wyman-Chick, Phillip K Martin, Michal Minár, Ryan W Schroeder
OBJECTIVE AND BACKGROUND: More than 10% of patients clinically diagnosed with Parkinson disease demonstrate normal dopamine uptake on dopamine transporter single-photon emission computed tomography (DaTscan), but little is known about how cognitive function differs between patients with dopamine deficiency on DaTscan and patients with scans without evidence of dopaminergic deficit (SWEDD). We compared the cognitive function of these two groups of patients over 2 years. METHODS: We retrospectively analyzed data obtained from the Parkinson's Progression Markers Initiative on 309 participants clinically diagnosed with idiopathic Parkinson disease who had scored in the normal range on the Montreal Cognitive Assessment at baseline and had completed 1- and 2-year follow-up visits...
2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27909286/three-cases-of-levodopa-resistant-parkinsonism-after-radiation-therapy
#7
Raja Mehanna, Joohi Jimenez-Shahed, Ilia Itin
BACKGROUND Unequivocal brain radiation-induced parkinsonism has so far been reported in only in two pediatric patients. However, with the rising incidence rates for brain tumors in industrialized countries and the consequential increased exposure to cranial radiotherapy, clinicians might become more exposed to this entity. CASE REPORT Three patients were treated for intraparenchymal brain tumor with resection, chemotherapy, and whole brain radiation. One patient developed leukoencephalopathy and parkinsonism within one year of treatment, one developed it seven years after treatment completion, and one developed dementia, parkinsonism and cerebral infracts 40 years after whole brain radiation...
December 2, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27844089/-biomarkers-for-dementia-and-other-neurodegenerative-diseases-current-developments
#8
J Wiltfang, P Lewczuk, M Otto
Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) support the early and differential diagnosis of dementia, most importantly the diagnosis of early or preclinical Alzheimer's dementia (AD). Meanwhile CSF-NDD are now recommended for improved exclusion and positive diagnostics of AD by the German national neuropsychiatry S3 dementia guidelines ( www.DGPPN.de ). Meta-analyses of independent international multicenter studies have shown that a combined CSF analysis of amyloid-beta 1-42 (Aβ 1-42, decreased), total tau proteins (increased) and phospho-tau proteins (increased) offers a sensitivity and specificity of 80-90 % for the early and differential diagnosis of AD (AD versus all other)...
December 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27813429/clinical-utility-of-datscan%C3%A2-imaging-in-the-evaluation-of-patients-with-parkinsonism-a-us-perspective
#9
Stuart H Isaacson, Stanley Fisher, Fiona Gupta, Neal Hermanowicz, Daniel E Kremens, Mark F Lew, Kenneth Marek, Rajesh Pahwa, David S Russell, John Seibyl
Single photon emission computed tomography (SPECT) with Ioflupane I123 injection (DaTscan™) was approved by the Food and Drug Administration in 2011 for striatal dopamine transporter visualization to assist in the evaluation of adult patients with suspected parkinsonian syndromes. While brain SPECT imaging using DaTscan is a covered service under Medicare policy, there is a lack of consensus on its role in routine clinical practice in the US. Areas covered: To address this issue, an expert group of US-based movement disorders neurologists convened to discuss the clinical utility of DaTscan in movement disorders practices within the US...
March 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27750247/transcranial-sonography-and-datscan-in-early-stage-parkinson-s-disease-and-essential-tremor
#10
Joana Jesus-Ribeiro, António Freire, João Sargento-Freitas, Mário Sousa, Fernando Silva, Fradique Moreira, Maria João Cunha, Uwe Walter, Cristina Januário
BACKGROUND: The diagnosis of Parkinson's disease (PD) can sometimes be a challenge in the early stages of the disease. Both transcranial sonography (TCS) and DaTSCAN are recommended as auxiliary examinations for the differential diagnosis of PD; however, only few data exist regarding their diagnostic accuracy in the early stage of PD and essential tremor (ET). METHODS: We evaluated patients with clinically suspected diagnosis of PD at early stages (Hoehn and Yahr ≤2) or ET...
2016: European Neurology
https://www.readbyqxmd.com/read/27730415/machine-learning-interface-for-medical-image-analysis
#11
Yi C Zhang, Alexander C Kagen
TensorFlow is a second-generation open-source machine learning software library with a built-in framework for implementing neural networks in wide variety of perceptual tasks. Although TensorFlow usage is well established with computer vision datasets, the TensorFlow interface with DICOM formats for medical imaging remains to be established. Our goal is to extend the TensorFlow API to accept raw DICOM images as input; 1513 DaTscan DICOM images were obtained from the Parkinson's Progression Markers Initiative (PPMI) database...
October 11, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27649003/subarachnoid-hemorrhage-and-extrapyramidal-symptoms-a-case-report
#12
Patrizia Mammi, Rodolfo Brianti, Laura Galuppo, Paolo Caffarra
INTRODUCTION: Parkinsonism may occur after brain lesions such as subarachnoid hemorrhage (1), hydrocephalus (2,3), slit ventricle (4), or shunt revision (5).Until now, pathogenesis remains unclear. METHOD: Case Report. RESULTS: We described the case of a 53 years Caucasian male with subarachnoid hemorrhage after anterior communicating artery aneurysm rupture, with subsequent complications and early development of bilateral extrapiramidal symptoms...
2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27614874/clinical-impact-of-123i-ioflupane-spect-datscan-in-a-movement-disorder-center
#13
Allison K Graebner, Daniel Tarsy, Ludy C Shih, Veronique Vanderhorst, Omesh Kulkarni, Scott Kaplan, David K Simon
BACKGROUND/AIMS: The clinical diagnosis of degenerative forms of parkinsonism is imperfect, with past studies reporting a high rate of misdiagnosis by neurologists and movement disorder specialists, particularly early in the disease course. 123I-ioflupane SPECT (DaTscan) is a diagnostic neuroimaging tool used to distinguish essential tremor from tremor due to degenerative parkinsonisms. The present study expands upon prior studies of the clinical impact of DaTscan imaging in movement disorder centers by assessing quantitative estimates of diagnostic certainty, the impact on subsequent clinical decisions, and the degree to which the asymmetry in the results corresponds to laterality by clinical history and examination...
September 10, 2016: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27544504/evaluation-of-parkinsonism-and-striatal-dopamine-transporter-loss-in-patients-with-spinocerebellar-ataxia-type-6
#14
Tao Xie, Daniel Appelbaum, Jacqueline Bernard, Mahesh Padmanaban, Yonglin Pu, Christopher Gomez
It is unclear whether patients with spinocerebellar ataxia type 6 (SCA6) have parkinsonism and striatal dopamine transporter (DAT) loss, based on previously small size studies without well-matched controls. A study with a larger number of patients and both age- and gender-matched healthy controls (HCs) is needed for a better answer to this question. Twelve genetically confirmed ataxic SCA6 patients (six male six female, age 65.3 ± 11.2 years), and eight age- and gender-matched HCs (five male three female, age 71...
November 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27544223/computed-tomography-guided-anatomic-standardization-for-quantitative-assessment-of-dopamine-transporter-spect
#15
Kota Yokoyama, Etsuko Imabayashi, Kaoru Sumida, Daichi Sone, Yukio Kimura, Noriko Sato, Youhei Mukai, Miho Murata, Hiroshi Matsuda
PURPOSE: For the quantitative assessment of dopamine transporter (DAT) using [(123)I]FP-CIT single-photon emission computed tomography (SPECT) (DaTscan), anatomic standardization is preferable for achieving objective and user-independent quantification of striatal binding using a volume-of-interest (VOI) template. However, low accumulation of DAT in Parkinson's disease (PD) would lead to a deformation error when using a DaTscan-specific template without any structural information. To avoid this deformation error, we applied computed tomography (CT) data obtained using SPECT/CT equipment to anatomic standardization...
March 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27517671/a-case-of-lithium-induced-parkinsonism-presenting-with-typical-motor-symptoms-of-parkinson-s-disease-in-a-bipolar-patient
#16
Adriana P Hermida, A Umair Janjua, Oliver M Glass, Camille P Vaughan, Felicia Goldstein, Lynn Marie Trotti, Stewart A Factor
Lithium is a mood stabilizer rarely associated with drug-induced parkinsonism (DIP). We present a case of an elderly woman with bipolar disorder who developed parkinsonian symptoms after chronic lithium administration despite therapeutic serum levels. Upon evaluation, classic parkinsonian signs of muscle rigidity, tremor, bradykinesia, freezing of gait, and cognitive decline were observed. Initially, she was diagnosed with Parkinson's disease (PD); however, DaTscan SPECT imaging clarified the diagnosis as DIP...
December 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27511183/evolution-of-clinical-features-in-possible-dlb-depending-on-fp-cit-spect-result
#17
Zuzana Walker, Emilio Moreno, Alan Thomas, Fraser Inglis, Naji Tabet, Tim Stevens, Tim Whitfield, Dag Aarsland, Michael Rainer, Alessandro Padovani
OBJECTIVE: To test the hypothesis that core and suggestive features in possible dementia with Lewy bodies (DLB) would vary in their ability to predict an abnormal dopamine transporter scan and therefore a follow-up diagnosis of probable DLB. A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the (123)I-FP-CIT SPECT scan result. METHODS: A total of 187 patients with possible DLB (dementia plus one core or one suggestive feature) were randomized to have dopamine transporter imaging or to follow-up without scan...
September 6, 2016: Neurology
https://www.readbyqxmd.com/read/27309537/n-acetyl-cysteine-may-support-dopamine-neurons-in-parkinson-s-disease-preliminary-clinical-and-cell-line-data
#18
Daniel A Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A Wintering, Jingli Cai, Xiatao Wei, Anthony J Bazzan, Li Zhong, Brendan Bowen, Charles M Intenzo, Lorraine Iacovitti, Andrew B Newberg
BACKGOUND: The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD). METHODS: The overarching goal of this pilot study was to generate additional data about potentially protective properties of NAC in PD, using an in vitro and in vivo approach. In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD...
2016: PloS One
https://www.readbyqxmd.com/read/27293063/datscan-in-differential-diagnostics-of-lewy-body-disease
#19
Jan Luzny, Katerina Ivanova
Differential diagnosis between Lewy body disease and Alzheimer´s disease might be difficult because of similarities of clinical symptoms in both neurodegenerative diseases. DatSCAN is a modern functional neuroimmaging method which differentiates between this similar diseases and helps in correct treatment strategy. We report our positive experience with DatSCAN in differentiating Lewy body disease from Alzheimer´s disease. This is a case report of a woman with Lewy body disease, initially diagnosed as Alzheimer´s disease...
June 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27264342/impulse-control-disorder-in-pd-a-lateralized-monoaminergic-frontostriatal-disconnection-syndrome
#20
E Premi, A Pilotto, V Garibotto, B Bigni, R Turrone, A Alberici, E Cottini, L Poli, M Bianchi, A Formenti, M Cosseddu, S Gazzina, M Magoni, M Bertoli, B Paghera, B Borroni, A Padovani
BACKGROUND: Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. METHODS: 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM)...
September 2016: Parkinsonism & related Disorders
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