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https://www.readbyqxmd.com/read/28534760/minibrain-storm-cerebral-organoids-aren-t-real-brains-but-they-provide-a-powerful-platform-for-modeling-brain-diseases-like-zika-infection-alzheimer-s-and-even-autism
#1
Shannon Fischer
Floating in a Petri dish, they look like tiny tapioca pearls in peach broth, a couple dozen in number and none much larger than the tip of a ballpoint pen. But under a microscope, dense, lumpy bodies come into focus, outlined by wispy coronas.
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28531950/modelling-pesticides-volatilisation-in-greenhouses-sensitivity-analysis-of-a-modified-pearl-model
#2
Michael Houbraken, Kim Doan Ngoc, Frederik van den Berg, Pieter Spanoghe
BACKGROUND: The application of the existing PEARL model was extended to include estimations of the concentration of crop protection products in greenhouse (indoor) air due to volatilisation from the plant surface. The model was modified to include the processes of ventilation of the greenhouse air to the outside atmosphere and transformation in the air. RESULTS: A sensitivity analysis of the model was performed by varying selected input parameters on a one-by-one basis and comparing the model outputs with the outputs of the reference scenarios...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28530602/bioactive-compound-and-antioxidant-activity-distribution-in-roller-milled-and-pearled-fractions-of-conventional-and-pigmented-wheat-varieties
#3
Debora Giordano, Monica Locatelli, Fabiano Travaglia, Matteo Bordiga, Amedeo Reyneri, Jean Daniel Coïsson, Massimo Blandino
In this study, the chemical composition of pigmented wheats (yellow, purple and blue types), and the distribution of the bioactive compounds in their roller-milled and pearled fractions, were compared with conventional wheats (red and white types). Roller-milling promoted the recovery of total dietary fiber, β-glucans, phenolic acids and anthocyanins in the bran fraction, which resulted also in a higher total antioxidant activity than the refined flour. Conversely, lutein resulted mainly concentrated in the refined flour...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28527752/so-you-want-to-be-published-pearls-for-journal-publishing
#4
EDITORIAL
Lauren L Patton
No abstract text is available yet for this article.
April 13, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28524157/gp-participation-in-increasing-uptake-in-a-national-bowel-cancer-screening-programme-the-pearl-project
#5
Sally C Benton, Piers Butler, Katy Allen, Michelle Chesters, Sally Rickard, Sally Stanley, Richard Roope, Daniel Vulkan, Stephen W Duffy
BACKGROUND: The NHS Bowel Cancer Screening Programme (BCSP) in England does not involve general practitioners (GPs). Uptake is ∼58%. The Practice Endorsed Additional Reminder Letter (PEARL) study piloted a GP-endorsed reminder letter. METHODS: General practices in Wessex with uptake <55% (prevalent invitations) were invited to participate. Subjects who had been invited for screening, sent a standard 28-day BCSP reminder letter but had not returned a test kit within 30 days of the standard reminder were sent a second reminder letter bearing the GP's letterhead and signature...
May 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28523513/erratum-to-high-interspecimen-variability-in-engagement-of-the-anterolateral-ligament-an-in-vitro-cadaveric-study
#6
Robert N Kent, James F Boorman-Padgett, Ran Thein, Jelle P van der List, Danyal H Nawabi, Thomas L Wickiewicz, Carl W Imhauser, Andrew D Pearle
No abstract text is available yet for this article.
May 18, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28522935/penile-ossification-a-reconstructive-challenge
#7
Arthi Satyanarayan, Nirmish Singla, Allen F Morey
Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Penile ossification remains a poorly understood, unusual entity that may pose a reconstructive challenge for urologists...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28522072/cardiovascular-magnetic-resonance-in-systemic-sclerosis-pearls-and-pitfalls
#8
REVIEW
Sophie I Mavrogeni, Juerg Schwitter, Luna Gargani, Alessia Pepe, Lorenzo Monti, Yannick Allanore, Marco Matucci-Cerinic
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular dysfunction and excessive fibrosis, involving internal organs including the heart. The estimated prevalence of cardiac involvement in SSc is high and remains subclinical until the late stages. It is either primary, related to myocardial inflammation and fibrosis, or secondary, due to pulmonary arterial hypertension (SSc-PAH) or systemic hypertension, in those patients with renal involvement. Cardiovascular magnetic resonance (CMR) is a useful tool for the early assessment of cardiac involvement in SSc...
March 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28521166/factors-controlling-cadmium-and-lead-activities-in-different-parent-material-derived-soils-from-the-pearl-river-basin
#9
Shuran He, Qin Lu, Wenyan Li, Zongling Ren, Zhen Zhou, Xiao Feng, Yulong Zhang, Yongtao Li
Labile metals in agricultural soils are available to crops and thus pose a great health risk for human beings. Therefore, factors influencing heavy metal activity are of interest to researchers. In this study, a total of 142 soil samples representing 5 typical parent materials in the Pearl River Basin (PRB), China were collected to investigate factors impacting the distribution of labile Cd and Pb in the soils. The results showed that the labile fractions accounted for 0.03%-14.7% for Cd and 0.01%-0.39% for Pb of the total metals, and the labile fractions were linearly correlated to their corresponding total contents...
May 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28513468/structural-evolution-during-calcination-and-sintering-of-a-la-sub-0-6-sub-sr-sub-0-4-sub-sub-0-99-sub-coo-sub-3-%C3%AE-sub-nanofiber-prepared-by-electrospinning
#10
Søren Simonsen, Jing Shao, Wenjing Zhang
Design of 3-dimensional metal oxide nanofibers by electrospinning is being widely explored. However, the impacts of calcination and sintering on the resulting morphology remain unknown. For the first time, (La<sub>0.6</sub>Sr<sub>0.4</sub>)<sub>0.99</sub>CoO<sub>3-δ</sub> (LSC) nanofiber, which is among the most promising electrode materials for solid oxide fuel cells, was synthesized by sol-gel electrospinning. By elevating the temperature in oxygen using in situ transmission electron microscopy, we discovered the structural transitions from nanofibers to nanotubes and then to nano-pearl strings...
May 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28513191/the-antecedents-and-outcomes-of-dyadic-coping-in-close-personal-relationships-a-systematic-review-and-narrative-synthesis
#11
Helen R Staff, Faye F Didymus, Susan H Backhouse
BACKGROUND AND OBJECTIVES: Theories of dyadic coping and empirical literature have intermittently and inconsistently highlighted antecedents and outcomes of dyadic coping. The purpose of this review was to systematically identify the antecedents and outcomes of dyadic coping in close personal relationships. DESIGN: A PRISMA-guided systematic review and narrative synthesis. METHODS: Literature searches were conducted using CINAHL, PubMed, PsycINFO, and citation pearl growing to identify studies that were relevant to the aim of the review...
May 17, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/28508613/genetic-mutations-birth-lengths-weights-and-head-circumferences-of-children-with-igf-i-receptor-defects-comparison-with-other-congenital-defects-in-the-gh-igf-i-axis
#12
Jenna Lee Essakow, Aharon Lauterpacht, Pearl Lilos, Rivka Kauli, Zvi Laron
BACKGROUND: In recent years more and more genetic defects along the GHRH-GH-IGF-I axis have been reported. Mutations of the IGF-I receptor (R) are a rare abnormality of whom only the heterozygote progenies survive. OBJECTIVES: To summarize, from the literature, data on birth length, weight and head circumference of neonates with IGF-I-R mutations, and to correlate the data with that of other types of mutations in the GH/IGF-I axis. SUBJECTS: Sixty seven neonates from 24 published articles were included and forty seven different mutations of the IGF-I (R) located on chromosome 15 have been identified...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28507551/deciphering-genomic-regions-for-high-grain-iron-and-zinc-content-using-association-mapping-in-pearl-millet
#13
N Anuradha, C Tara Satyavathi, C Bharadwaj, T Nepolean, S Mukesh Sankar, Sumer P Singh, Mahesh C Meena, Tripti Singhal, Rakesh K Srivastava
Micronutrient malnutrition, especially deficiency of two mineral elements, iron [Fe] and zinc [Zn] in the developing world needs urgent attention. Pearl millet is one of the best crops with many nutritional properties and is accessible to the poor. We report findings of the first attempt to mine favorable alleles for grain iron and zinc content through association mapping in pearl millet. An association mapping panel of 130 diverse lines was evaluated at Delhi, Jodhpur and Dharwad, representing all the three pearl millet growing agro-climatic zones of India, during 2014 and 2015...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28503985/diagnostic-and-therapeutic-management-of-a-first-unprovoked-seizure-in-children-and-adolescents-with-a-focus-on-the-revised-diagnostic-criteria-for-epilepsy
#14
Arnold J Sansevere, Jennifer Avalone, Lauren Doyle Strauss, Archana A Patel, Anna Pinto, Maya Ramachandran, Ivan Sanchez Fernandez, Ann M Bergin, Amir Kimia, Phillip L Pearl, Tobias Loddenkemper
By definition, unprovoked seizures are not precipitated by an identifiable factor, such as fever or trauma. A thorough history and physical examination are essential to caring for pediatric patients with a potential first unprovoked seizure. Differential diagnosis, EEG, neuroimaging, laboratory tests, and initiation of treatment will be reviewed. Treatment is typically initiated after 2 unprovoked seizures, or after 1 seizure in select patients with distinct epilepsy syndromes. Recent expansion of the definition of epilepsy by the ILAE allows for the diagnosis of epilepsy to be made after the first seizure if the clinical presentation and supporting diagnostic studies suggest a greater than 60% chance of a second seizure...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28503347/wasting-of-extensor-digitorum-brevis-as-a-decisive-preoperative-clinical-indicator-of-lumbar-canal-stenosis-a-single-center-prospective-cohort-study
#15
S Munakomi, B M Kumar
BACKGROUND: The dilemma in managing patients with low back ache lies in differentiating radiculopathy from lumbar canal stenosis. This has a huge bearing in patients being planned for surgical intervention as underperforming leads to failed back syndrome whereas over-doing leads to instability. There still remains a loophole in clinically diagnosing lumbar canal stenosis. AIM: We opt to utilize a simple bedside clinical examination in routinely assessing patients presenting with low back ache in ruling out underlying canal stenosis...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28502359/pearls-and-pitfalls-for-a-surgeon-new-to-ankle-replacements
#16
REVIEW
Federico Giuseppe Usuelli, Camilla Maccario
The role of the surgeon learning curve in total ankle replacement (TAR) has produced contradictory results. It is important for a new surgeon to know what clinical and radiological parameters are considered reliable and ideal. It is clear that exposure to a high-volume center will increase the reliability of a new surgeon approaching TAR. Implant choice may be influenced by surgeon training, and the debate of mobile versus fix-bearing prosthesis is still open. Anterior versus lateral approach is still an open debate, with any hypothetical advantages given by the direct vision on the center of rotation to be proven...
June 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28501074/scared-to-the-marrow-pitfalls-and-pearls-in-renal-imaging
#17
EDITORIAL
Brent Wagner
No abstract text is available yet for this article.
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28500323/development-of-an-inducible-mouse-model-of-irfp713-to-track-recombinase-activity-and-tumour-development-in-vivo
#18
Andreas K Hock, Eric C Cheung, Timothy J Humpton, Tiziana Monteverde, Viola Paulus-Hock, Pearl Lee, Ewan McGhee, Alessandro Scopelliti, Daniel J Murphy, Douglas Strathdee, Karen Blyth, Karen H Vousden
While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue penetration and high background autofluorescence. To overcome these limitations, we generated an inducible knock-in mouse model of iRFP713. This model was used to assess Cre activity in a Rosa Cre-ER background and quantify Cre activity upon different tamoxifen treatments in several organs...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499376/benefits-of-preparing-for-childbirth-with-mindfulness-training-a-randomized-controlled-trial-with-active-comparison
#19
Larissa G Duncan, Michael A Cohn, Maria T Chao, Joseph G Cook, Jane Riccobono, Nancy Bardacke
BACKGROUND: Childbirth fear is linked with lower labor pain tolerance and worse postpartum adjustment. Empirically validated childbirth preparation options are lacking for pregnant women facing this problem. Mindfulness approaches, now widely disseminated, can alleviate symptoms of both chronic and acute pain and improve psychological adjustment, suggesting potential benefit when applied to childbirth education. METHODS: This study, the Prenatal Education About Reducing Labor Stress (PEARLS) study, is a randomized controlled trial (RCT; n = 30) of a short, time-intensive, 2...
May 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28497511/effects-of-medical-trainees-weight-loss-history-on-perceptions-of-patients-with-obesity
#20
Rebecca L Pearl, Dallas Argueso, Thomas A Wadden
CONTEXT: Medical professionals often express weight-biased attitudes. Prior research suggests that people who overcome a challenge are critical of individuals who struggle to overcome the same challenge. Thus, medical trainees who have successfully achieved and maintained weight loss may express greater weight bias and more critical attitudes toward patients with obesity who fail to overcome these challenges. OBJECTIVES: This study was designed to determine the effects of medical trainees' weight-loss history on weight-biased attitudes and responses to patients with varying weight-loss outcomes...
May 11, 2017: Medical Education
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