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https://www.readbyqxmd.com/read/29350569/practice-pearl-liraglutide-and-cardiovascular-and-renal-events-in-type-2-diabetes
#1
Robert Guthrie
Review of: Marso S, Daniels G, Brown-Frandsen K, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016; 375: 311-322. Mann J, Orsted D, Brown-Frandsen K, et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017; 377: 839-848. This comprehensive research project, LEADER, led to two reports, one focusing on the effect of liraglutide on cardiovascular events, and the second one reporting on the renal effects on the same study population. The study group included 9340 patients with type 2 diabetes...
January 19, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29349034/arthroscopic-microfracture-of-hip-chondral-lesions
#2
H Atil Atilla, T David Luo, Allston J Stubbs
Microfracture of hip chondral lesions has been performed for more than a decade with modified treatment principles and techniques from knee arthroscopy. This note and accompanying video review the pertinent techniques, pearls, and pitfalls of the microfracture procedure in the treatment of hip chondral lesions. After debridement of damaged chondral tissue, the size of the lesion is approximated to determine the number of microfracture holes to create. The working portal may be adjusted based on the site of the lesion...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349019/arthroscopic-decompression-of-greater-trochanteric-sciatic-nerve-impingement
#3
Shane Tipton, Ian Alkhafaji, Rebecca Senehi, Allston Stubbs
Therapeutic extra-articular hip endoscopy is an effective treatment of greater trochanteric sciatic nerve impingement. We describe in detail technical pearls of the procedure including positioning, portal placement, and steps to obtaining adequate decompression while avoiding iatrogenic nerve injury.
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349018/open-4-compartment-fasciotomy-for-chronic-exertional-compartment-syndrome-of-the-leg
#4
Amos Z Dai, Michael Zacchilli, Neha Jejurikar, Hien Pham, Laith Jazrawi
Chronic exertional compartment syndrome (CECS) is a significant source of lower extremity pain and morbidity in the athletic population. Although endoscopic techniques have been introduced, open fasciotomy remains the mainstay of surgical treatment because of the paucity of evidence in support of an endoscopic approach. The literature on surgical management of CECS is mixed, and overall success rates are modest at best. Optimizing surgical technique, including prevention of neurovascular injury and wound complications, can make a significant impact on the clinical outcome...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349010/arthroscopic-repair-of-hip-labrum-with-suture-anchors
#5
Kartik Shenoy, Amos Z Dai, Siddharth A Mahure, Daniel J Kaplan, Brian Capogna, Thomas Youm
The acetabular labrum and the transverse acetabular ligament form a continuous ring of tissue on the periphery of the acetabulum that provides a seal for the hip joint and increases the surface area to spread load distribution during weight-bearing. When a labral tear is suspected, the treatment algorithm always begins with conservative management, including physical therapy and nonsteroidal anti-inflammatory drugs. When conservative management fails, patients become candidates for arthroscopic labral repair...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349008/meniscal-allograft-transplantation-made-simple-bridge-and-slot-technique
#6
Daniel J Kaplan, Sergio A Glait, William E Ryan, Michael J Alaia, Kirk A Campbell, Eric J Strauss, Laith M Jazrawi
Over recent years, appreciation for the critical role of the meniscus in joint biomechanics has led to an emphasis on meniscal preservation. Meniscal allograft transplant (MAT) is a promising biological solution for the symptomatic young patient with a meniscus-deficient knee that has not developed advanced osteoarthritis. As surgical techniques are refined and outcomes continue to improve, it is vital to consider the utility of such procedures and offer a straightforward approach to MAT. This article and accompanying video provide a step-by-step tutorial on how to perform a MAT using the bridge and slot technique, its key pearls and pitfalls as well as the relevant advantages and disadvantages of MAT...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29347751/surface-deformation-during-an-action-potential-in-pearled-cells
#7
Matan Mussel, Christian Fillafer, Gal Ben-Porath, Matthias F Schneider
Electric pulses in biological cells (action potentials) have been reported to be accompanied by a propagating cell-surface deformation with a nanoscale amplitude. Typically, this cell surface is covered by external layers of polymer material (extracellular matrix, cell wall material, etc.). It was recently demonstrated in excitable plant cells (Chara braunii) that the rigid external layer (cell wall) hinders the underlying deformation. When the cell membrane was separated from the cell wall by osmosis, a mechanical deformation, in the micrometer range, was observed upon excitation of the cell...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346000/preventable-emergency-department-visits-for-nontraumatic-dental-conditions-trends-and-disparities-in-nevada-2009-2015
#8
Wenlian Zhou, Pearl Kim, Jay J Shen, Joseph Greenway, Marcia Ditmyer
OBJECTIVES: To examine trends and socioeconomic disparities for preventable dental-related emergency department (ED) visits in Nevada. METHODS: We pooled retrospective data containing 66 267 ED visits involving dental conditions from Nevada hospital ED databases from 2009 to 2015. The dependent variable was nontraumatic dental conditions identified by International Classification of Diseases, Ninth Revision, codes; 3 independent variables included treatment year, health insurance status, and race/ethnicity...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29344777/giant-cell-arteritis-practical-pearls-and-updates
#9
REVIEW
Swati Pradeep, Jonathan H Smith
PURPOSE OF REVIEW: The purpose of this review is to summarize recent updates and distill practical points from the literature which can be applied to the care of patients with suspected and confirmed giant cell arteritis (GCA). RECENT FINDINGS: Contemporary thinking implicates a fundamental failure of T regulatory cell function in GCA pathophysiology, representing opportunity for novel therapeutic avenues. Tocilizumab has become the first Food and Drug Administration-approved treatment for GCA following demonstration of efficacy and safety in a phase 3 clinical trial...
January 17, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29344055/non-organic-vision-loss-in-the-afghanistan-and-iraq-conflicts
#10
Kevin M Broderick, Thomas B Ableman, Eric D Weber, Robert W Enzenauer, Harold J Wain, Keith J Wroblewski
Non-organic visual loss (NOVL), defined as a decrease in visual acuity or field without an identifiable organic cause, can be challenging to diagnose, especially in patients whose NOVL is superimposed on some component of true organic pathology. Exposure to combat puts soldiers at risk of emotional distress and physical trauma, which can contribute to the development of NOVL with conversion disorder or malingering. This case series describes six patients with NOVL who sustained ocular or non-ocular injuries while serving in combat operations in Iraq and Afghanistan, and highlights diagnostic pearls and components of inter-disciplinary management in the unique military context...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29340846/novel-isoforms-of-n16-and-n19-families-implicated-for-the-nacreous-layer-formation-in-the-pearl-oyster-pinctada-fucata
#11
Fumito Ohmori, Shigeharu Kinoshita, Daisuke Funabara, Hiroki Koyama, Kiyohito Nagai, Kaoru Maeyama, Kikuhiko Okamoto, Shuichi Asakawa, Shugo Watabe
Although a wide variety of proteins and genes possibly related to the shell formation in bivalve have been identified, their functions have been only partially approved. We have recently performed deep sequencing of expressed sequence tags (ESTs) from the pearl oyster Pinctada fucata using a next-generation sequencer, identifying a dozen of novel gene candidates which are possibly associated with the nacreous layer formation. Among the ESTs, we focused on three novel isoforms (N16-6, N16-7, and N19-2) of N16 and N19 families with reference to five known genes in the families and determined the full-length cDNA sequences of these isoforms...
January 16, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29339340/bioavailability-and-soil-to-crop-transfer-of-heavy-metals-in-farmland-soils-a-case-study-in-the-pearl-river-delta-south-china
#12
Jingru Zhang, Huizhen Li, Yongzhang Zhou, Lei Dou, Limei Cai, Liping Mo, Jing You
Soil-bound heavy metals are of great concern for human health due to the potential exposure via food chain transfer. In the present study, the occurrence, the bioavailability and the soil-to-crop transfer of heavy metals in farmland soils were investigated based on data from two agricultural areas, i.e. Sihui and Shunde in South China. Six heavy metals (As, Cu, Hg, Mn, Ni and Pb) were quantified in the farmland soils. The mean single pollution level indices (PI) were all lower than 1 except for Hg in soils from Shunde (PI = 1...
January 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29335306/pearls-oy-sters-family-history-of-huntington-disease-disguised-a-case-of-dentatorubral-pallidoluysian-atrophy
#13
Sinem Tunc, Vera Tadic, Christine Zühlke, Yorck Hellenbroich, Norbert Brüggemann
No abstract text is available yet for this article.
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29334946/surmounting-difficulties-to-provide-home-based-neonatal-care-reflections-of-community-health-workers
#14
Abhijit Shrinivas Prabhughate, Pearl Tiwari, Shubhangi Sohoni, Vallaree Anant Morgaonkar, Ajay Gajanan Phatak, Somashekhar Marutirao Nimbalkar, Anagha Anand Mahajani
BACKGROUND: In India, community health workers' (CHW) effectiveness in providing home-based neonatal care (HBNC) has been well documented. The nature of challenges faced and strategies adopted while providing HBNC services need to be studied in-depth. METHODS: A qualitative study to understand the challenges faced and strategies used by Sakhis (women CHW) while providing services as part of a HBNC program implemented by a non-profit organization. Data consisted of 20 in-depth interviews and three focus group discussions (FGD) with Sakhis...
January 15, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29333023/nivolumab-pearls-of-evidence
#15
REVIEW
Pratishtha B Chaudhari
Purpose: Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods: Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, and Cochrane Central through September 2016 for controlled prospective interventional studies of nivolumab across two indications - NSCLC and RCC...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332368/-pearl-oyster-a-new-ultrasonographic-sign-of-the-regressed-testicular-tumor
#16
Lucio Dell'Atti, Andrea Benedetto Galosi
No abstract text is available yet for this article.
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29329533/nutritional-status-of-in-school-children-and-its-associated-factors-in-denkyembour-district-eastern-region-ghana-comparing-schools-with-feeding-and-non-school-feeding-policies
#17
Mavis Pearl Kwabla, Charlotte Gyan, Francis Zotor
BACKGROUND: Childhood malnutrition still remains a major public health problem impacting negatively on the academic aptitude of school-aged children (SAC) particularly in limited resource countries. The Government of Ghana in collaboration with the Dutch Government introduced the school feeding programme (SFP) to boost the nutritional status of SAC in the country. This study sought to compare the nutritional status of SAC enrolled in schools with the SFP and SAC enrolled in schools without the SFP in place for the purpose of identifying which group has the higher rate of malnutrition...
January 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29326194/association-of-erythrocyte-parameters-with-metabolic-syndrome-in-the-pearl-river-delta-region-of-china-a-cross-sectional-study
#18
Ling Ling Huang, Dong-Mei Dou, Nan Liu, Xiao Xiao Wang, Li-Ying Fu, Xiao Wu, Peixi Wang
OBJECTIVE: Increasing studies have reported that erythrocyte parameters, including red blood cells (RBCs), haematocrit (HCT), haemoglobin (Hb) and red blood cell distribution width (RDW), are associated with metabolic syndrome (MetS) in adults worldwide. However, the association, stratified by sex, remains to be elucidated, particularly in the Pearl River Delta region of China. Therefore, our aim was to explore the association of erythrocyte parameters with MetS, stratified by sex, in the Pearl River Delta region of China...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29323067/modified-cajal-s-trichrome-stain-as-a-diagnostic-aid-in-the-study-of-epithelial-pathology
#19
Karpagaselvi Sanjai, Anjum Baker, Lokesh Papiah Reddy, Bhavna Pandey
BACKGROUND: Diagnosis of initial epithelial pathology maybe difficult in Squamous Cell Carcinoma (SCC), Carcinoma In Situ and other atypical epithelial malignancies, under routine Haematoxylin and Eosin (H and E) stain. The detection of minor basement membrane alterations in doubtful cases is both time consuming and confusing. AIMS: To evaluate efficacy of Modified Cajal's Trichrome Stain (CTS) in relation to Haematoxylin and Eosin for study of epithelial dysplasia, carcinoma in situ, micro invasive SCC, frank SCC, and SCC in lymph nodes...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29320333/prostate-specific-membrane-antigen-pet-clinical-utility-in-prostate-cancer-normal-patterns-pearls-and-pitfalls
#20
Michael S Hofman, Rodney J Hicks, Tobias Maurer, Matthias Eiber
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is overexpressed in prostate cancer. Radiolabeled small molecules that bind with high affinity to its active extracellular center have emerged as a potential new diagnostic standard of reference for prostate cancer, resulting in images with extraordinary tumor-to-background contrast. Currently, gallium 68 (68Ga)-PSMA-11 (or HBED-PSMA) is the most widely used radiotracer for PSMA positron emission tomography (PET)/computed tomography (CT) or PSMA PET/magnetic resonance (MR) imaging...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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