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https://www.readbyqxmd.com/read/28534493/usp13-negatively-regulates-antiviral-responses-by-deubiquitinating-sting
#1
He Sun, Qiang Zhang, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian-Chen Xiong, Yan Wu, Qi-Yun Zhu, Jing Yao, Hong-Bing Shu, Dandan Lin, Bo Zhong
STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific protease 13 (USP13) is a STING-interacting protein that catalyses deubiquitination of STING. Knockdown or knockout of USP13 potentiates activation of IRF3 and NF-κB and expression of downstream genes after HSV-1 infection or transfection of DNA ligands. USP13 deficiency results in impaired replication of HSV-1...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28532793/streptococcus-agalactiae-in-elephants-a-comparative-study-with-isolates-from-human-and-zoo-animal-and-livestock-origin
#2
Tobias Eisenberg, Jörg Rau, Uta Westerhüs, Tobias Knauf-Witzens, Ahmad Fawzy, Karen Schlez, Michael Zschöck, Ellen Prenger-Berninghoff, Carsten Heydel, Reinhard Sting, Stefanie P Glaeser, Dipen Pulami, Mark van der Linden, Christa Ewers
Streptococcus (S.) agalactiae represents a significant pathogen for humans and animals. However, there are only a few elderly reports on S. agalactiae infections in wild and zoo elephants even though this pathogen has been isolated comparatively frequently in these endangered animal species. Consequently, between 2004 and 2015, we collected S. agalactiae isolates from African and Asian elephants (n=23) living in four different zoos in Germany. These isolates were characterised and compared with isolates from other animal species (n=20 isolates) and humans (n=3)...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28522827/involvement-of-gata1-and-sp3-in-the-activation-of-the-murine-sting-gene-promoter-in-nih3t3-cells
#3
Yan-Yan Xu, Rui Jin, Guo-Ping Zhou, Hua-Guo Xu
Stimulator of Interferon Gene (STING) is a key mediator of innate immune signaling. STING plays a pivotal role in the pathogenesis of many diseases including infectious diseases, auto-immune diseases and cancer. Many studies have been carried out recently in the field of STING-regulated pathway, however, rarely of transcriptional mechanisms. To characterize the murine STING (mSTING) promoter, we cloned a series of different nucleotide sequences of the 5'-flanking region of the mSTING gene. Transient transfection of promoter-reporter recombinant plasmids and luciferase assay illustrated the region (-77/+177) relative to the transcription start site (TSS) of the mSTING gene was sufficient for full promoter activity...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514660/absence-of-specific-chlamydia-trachomatis-inclusion-membrane-proteins-triggers-premature-inclusion-membrane-lysis-and-host-cell-death
#4
Mary M Weber, Jennifer L Lam, Cheryl A Dooley, Nicholas F Noriea, Bryan T Hansen, Forrest H Hoyt, Aaron B Carmody, Gail L Sturdevant, Ted Hackstadt
Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic factors. Using recently developed genetic tools, we show that three inclusion membrane proteins (Incs) out of eleven examined are required for inclusion membrane stability and avoidance of host cell death pathways...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28513988/aquagenic-cutaneous-disorders
#5
REVIEW
Fang Wang, Yu-Kun Zhao, Ze-Yu Luo, Qian Gao, Wei Wu, Rashmi Sarkar, Di-Qing Luo
Aquagenic cutaneous disorders, which include aquagenic urticaria, aquagenic pruritus, and aquagenic acrokeratoderma, are a group of rare diseases characterized by skin lesions or discomfort induced by brief contact with water. Aquagenic urticaria is characterized by pruritic wheals that occur at the sites of water contact, either immediately or within minutes, and disappear within 30-60 min after water removal. Aquagenic pruritus presents with severe pruritus or a stinging, tingling, or burning sensation without any visible skin changes...
May 17, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28512240/sting-activation-reverses-lymphoma-mediated-resistance-to-antibody-immunotherapy
#6
Lekh N Dahal, Lang Dou, Khiyam Hussain, Rena Liu, Alexander Earley, Kerry L Cox, Salome Murinello, Ian Tracy, Francesco Forconi, Andrew J Steele, Patrick Duriez, Diego Gomez-Nicola, Jessica L Teeling, Martin J Glennie, Mark S Cragg, Stephen A Beers
Tumors routinely attract and co-opt macrophages to promote their growth, angiogenesis and metastasis. Macrophages are also the key effector cell for monoclonal antibody (mAb) therapies. Here we report that the tumor microenvironment creates an immunosuppressive signature on tumor-associated macrophages (TAM) which favors expression of inhibitory rather than activating Fcγ receptors (FcγR), thereby limiting the efficacy of mAb immunotherapy. We assessed a panel of TLR and STING agonists (a) for their ability to reprogram macrophages to a state optimal for mAb immunotherapy...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28512035/the-predatory-behavior-of-the-neotropical-social-wasp-polybia-rejecta
#7
Alain Dejean, Héctor Rodríguez-Pérez, James M Carpenter, Frédéric Azémar, Bruno Corbara
We experimentally studied the predatory behavior of Polybia rejecta (Vespidae, Polistinae, Epiponini) towards 2-88 mm-long insects attracted to a UV light trap. Foragers, which began to hunt at 6:30, selected 4-14 mm-long prey insects. Prey detection by sight by hovering wasps was confirmed using decoys. After the wasps landed and walked along a sinuous path, prey were detected by contact or from a distance (1-3cm). This was followed by seizure, stinging (contrarily to most other known cases), prey manipulation and retrieval...
May 13, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28511825/neuropsychiatric-factors-in-sensitive-skin
#8
Laurent Misery
Sensitive skin is a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that normally should not provoke such sensations. The worldwide prevalence of sensitive skin is approximately 40%. Clinical, histologic, biochemical, and therapeutic data show that this condition is related to changes in epidermal nerve endings with subsequent hyperreactivity and neurogenic inflammation; hence, sensitive skin is not a psychosomatic disorder, although psychologic consequences are possible...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28507496/safety-and-efficacy-of-venom-immunotherapy-a-real-life-study
#9
Agnieszka Kołaczek, Dawid Skorupa, Monika Antczak-Marczak, Piotr Kuna, Maciej Kupczyk
INTRODUCTION: Venom immunotherapy (VIT) is recommended as the first-line treatment for patients allergic to Hymenoptera venom. AIM: To analyze the safety and efficacy of VIT in a real life setting. MATERIAL AND METHODS: One hundred and eighty patients undergoing VIT were studied to evaluate the safety, efficacy, incidence and nature of symptoms after field stings and adverse reactions to VIT. RESULTS: Significantly more patients were allergic to wasp than bee venom (146 vs...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28503403/diagnostics-in-hymenoptera-venom-allergy-current-concepts-and-developments-with-special-focus-on-molecular-allergy-diagnostics
#10
Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller
BACKGROUND: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28503385/intervention-effects-of-five-cations-and-their-correction-on-hemolytic-activity-of-tentacle-extract-from-the-jellyfish-cyanea-capillata
#11
Hui Zhang, Qianqian Wang, Liang Xiao, Liming Zhang
Cations have generally been reported to prevent jellyfish venom-induced hemolysis through multiple mechanisms by spectrophotometry. Little attention has been paid to the potential interaction between cations and hemoglobin, potentially influencing the antagonistic effect of cations. Here, we explored the effects of five reported cations, La(3+), Mn(2+), Zn(2+), Cu(2+) and Fe(2+), on a hemolytic test system and the absorbance of hemoglobin, which was further used to measure their effects on the hemolysis of tentacle extract (TE) from the jellyfish Cyanea capillata...
2017: PeerJ
https://www.readbyqxmd.com/read/28499778/fatal-anaphylaxis-to-yellow-jacket-stings-in-mastocytosis-options-for-identification-and-treatment-of-at-risk-patients
#12
Byrthe J P R Vos, Bjorn van Anrooij, Jasper J van Doormaal, Anthony E J Dubois, Joanne N G Oude Elberink
BACKGROUND: Patients with indolent systemic mastocytosis (ISM) are at risk for severe anaphylactic reactions to yellow jacket (YJ) stings while demonstration of sensitization can be challenging because specific IgE (sIgE) levels are regularly below 0.35 kUA/L. The implication of missing YJ allergy is illustrated by a case of fatal anaphylaxis. OBJECTIVE: To explore the natural course of YJ venom allergy and the diagnostic accuracy and therapeutic consequence of YJ venom sIgE in patients with ISM...
May 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28497070/impact-of-polyethylene-glycol-400-propylene-glycol-hydroxypropyl-guar-and-0-1-sodium-hyaluronate-on-postoperative-discomfort-following-cataract-extraction-surgery-a-comparative-study
#13
Georgios Labiris, Panagiota Ntonti, Haris Sideroudi, Vassilios Kozobolis
BACKGROUND: Universal postoperative guidelines for cataract extraction surgery are yet to be introduced. Artificial tears are gaining popularity as an additional integral component of the postoperative regime. The primary objective of this study was to explore the impact of two prevalent artificial tear preparations on postoperative discomfort following cataract extraction surgery. METHODS: A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their postoperative regime: a) Study group 1 (SG1) received a fixed combination of tobramycin and dexamethasone (FCTD) quid for 3 weeks and, additionally polyethylene glycol 400/propylene glycol/hydroxypropyl-guar quid, for 6 weeks, b) Study group 2 (SG2) received FCTD quid for 3 weeks and, additionally 0...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28494206/component-resolved-evaluation-of-the-content-of-major-allergens-in-therapeutic-extracts-for-specific-immunotherapy-of-honeybee-venom-allergy
#14
Simon Blank, Stefanie Etzold, Ulf Darsow, Maximilian Schiener, Bernadette Eberlein, Dennis Russkamp, Sara Wolf, Anke Graessel, Tilo Biedermann, Markus Ollert, Carsten B Schmidt-Weber
Allergen-specific immunotherapy is the only curative treatment for honeybee venom (HBV) allergy, which is able to protect against further anaphylactic sting reactions. Recent analyses on a molecular level have demonstrated that HBV represents a complex allergen source that contains more relevant major allergens than formerly anticipated. Moreover, allergic patients show very diverse sensitization profiles with the different allergens. HBV-specific immunotherapy is conducted with HBV extracts which are derived from pure venom...
May 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28494175/the-effect-of-plasmapheresis-on-treating-disseminated-intravascular-coagulation-dic-caused-by-a-hemiscorpius-lepturus-gadim-sting
#15
Babak Mostafazadeh, Ahmad Gorbani, Mitra Mogaddaspour, Hamid Reza Khoddami Vishteh
INTRODUCTION: The highest mortality from scorpion stings in Iran is due to the stings of a particular type of scorpion known as Hemiscorpius lepturus (H. lepturus, Gadim in local language). The present study aimed at investigating the use of plasmapheresis to treat severe cases of H. lepturus stings. METHOD: This pilot study was a randomized clinical trial conducted from June 2015 to June 2016 in Razi hospital of Ahvaz, Iran. Twenty-nine patients who had been stung by H...
May 11, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28492291/crisaborole-phosphodiesterase-inhibitor-for-treatment-of-atopic-dermatitis
#16
D M Paton
Atopic dermatitis (AD) is an extremely common condition affecting as many as 10-20% of children and 2-10% of adults. A particularly distressing symptom of AD is pruritus. One of the important aspects of AD is inflammation associated with increased activity of phosphodiesterase 4 (PDE4), resulting in decreased intracellular levels of cyclic adenosine monophosphate, which in turn causes increased production of inflammatory cytokines. Crisaborole was developed as a small-molecule, boron-based, selective PDE4 inhibitor that can be used topically...
April 2017: Drugs of Today
https://www.readbyqxmd.com/read/28486123/evolution-taking-the-sting-out-of-wasp-phylogenetics
#17
Pu Tang, Alfried P Vogler
Hymenopterans - one of the 'big four' of insect orders - includes the sawflies, wasps, ants and bees. Two phylogenomic studies now resolve hymenopteran phylogeny and provide scenarios for the evolution of major lineages and key lifestyle transitions.
May 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28484079/intrinsic-antiproliferative-activity-of-the-innate-sensor-sting-in-t-lymphocytes
#18
Silvia Cerboni, Nadia Jeremiah, Matteo Gentili, Ulf Gehrmann, Cécile Conrad, Marie-Claude Stolzenberg, Capucine Picard, Bénédicte Neven, Alain Fischer, Sébastian Amigorena, Frédéric Rieux-Laucat, Nicolas Manel
Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate immune responses. However, the role of STING in adaptive immunity is still unknown. In this study, we show that STING activation reduces the proliferation of T lymphocytes. This activity was independent of TBK1 and IRF3 recruitment and of type I IFN but required a distinct C-terminal domain of STING that activates NF-κB. Inhibition of cell proliferation by STING required its relocalization to the Golgi apparatus and caused mitotic errors...
May 8, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28483787/a-sting-agonist-given-with-ox40-receptor-and-pd-l1-modulators-primes-immunity-and-reduces-tumor-growth-in-tolerized-mice
#19
Jeremy B Foote, Marleen Kok, James M Leatherman, Todd D Armstrong, Bridget C Marcinkowski, Laureen S Ojalvo, David B Kanne, Elizabeth M Jaffee, Thomas W Dubensky, Leisha A Emens
STING signaling induces interferon-β (IFNβ) production by intratumoral dendritic cells (DCs), driving T-cell priming and recruitment into the tumor microenvironment (TME). We examined to what extent pre-existing antigen tolerance influenced the efficacy of in situ delivery of a potent STING-activating cyclic dinucleotide (CDN), ADU S-100, against established HER-2(+) breast tumors. ADU S-100 induced HER-2-specific CD8(+) T-cell priming and durable tumor clearance in 100% of nontolerant parental FVB/N mice...
May 8, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28480951/arzneimittelinduzierte-anaphylaxie
#20
Ali Yildirim, Heinz-Theo Lübbers, Ayhan Yildirim
Anaphylaxis is defined as a serious allergic or hypersensitivity reaction in the most cases as a result of an IgE-mediated allergic reaction that is rapid in onset and may cause death. Common triggers are foods, insect stings, and medications. The medical treatment includes, epinephrine, glucocorticoids, antihistamines and inhaled bronchodilators, with the aim to prevent progression to life-threatening respiratory and/or cardiovascular symptoms.
2017: Swiss Dental Journal
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