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https://www.readbyqxmd.com/read/29471402/a-review-of-sclerodermus-latreille-1809-hymenoptera-bethylidae-infestations-and-report-of-the-first-case-in-north-america-north-of-mexico
#1
Michael J Skvarla
Sclerodermus Latreille, 1809 (Hymenoptera: Bethylidae), are parasitoids of wood-boring beetle larvae that can co-infest furniture and homes attacked by such larvae. This can result in the human inhabitants receiving stings from adult female wasps as they wander in search of new hosts. Herein, I report the first infestation of Sclerodermus macrogaster (Ashmead, 1887) of a home in North America and provide a review of Sclerodermus biology and clinical signs relevant to their pestiferous nature.
February 20, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29469797/a-gastronomic-delight
#2
Livia Francine Soriano, Bernard Cummings, Victoria Jolliffe
Flagellate dermatitis (FD) exhibits a striking clinical appearance similar to whiplash marks. General dermatologists are likely to encounter this clinical appearance as a more localized presentation of phytophotodermatosis. Jellyfish stings may also cause localized linear or FD. Chemotherapeutic agents such as bleomycin, doxorubicin, docetaxel, and trastuzumab are well-recognized causes of a widespread FD and it may more rarely be seen in connective tissue disease such as dermatomyositis or Still disease. In our case, this was a presentation of shiitake mushroom dermatitis...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469757/delusions-of-parasitosis-a-brief-review-of-the-literature-and-pathway-for-diagnosis-and-treatment
#3
Nicholas Laidler
A large proportion of patients seen in dermatology practices have underlying psychological issues associated with their skin diseases. One of the most flagrant examples of this are patients with delusions of parasitosis. These patients have false fixed beliefs that they are infested by parasites and experience cutaneous sensations of crawling, biting, and stinging associated with their delusions. There is no organic skin disorder and all cutaneous manifestations are self-induced. Rather than a psychiatrist, the dermatologist is often designated by the patient to handle the chief complaint, even though the main disorder is psychogenic...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29467580/history-of-morgellons-disease-from-delusion-to-definition
#4
REVIEW
Marianne J Middelveen, Melissa C Fesler, Raphael B Stricker
Morgellons disease (MD) is a skin condition characterized by the presence of multicolored filaments that lie under, are embedded in, or project from skin. Although the condition may have a longer history, disease matching the above description was first reported in the US in 2002. Since that time, the condition that we know as MD has become a polemic topic. Because individuals afflicted with the disease may have crawling or stinging sensations and sometimes believe they have an insect or parasite infestation, most medical practitioners consider MD a purely delusional disorder...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29467525/genomic-instability-the-sting-of-metastasis
#5
Sarah Seton-Rogers
No abstract text is available yet for this article.
February 22, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29466729/a-cell-intrinsic-interferon-like-response-links-replication-stress-to-cellular-aging-caused-by-progerin
#6
Ray Kreienkamp, Simona Graziano, Nuria Coll-Bonfill, Gonzalo Bedia-Diaz, Emily Cybulla, Alessandro Vindigni, Dale Dorsett, Nard Kubben, Luis Francisco Zirnberger Batista, Susana Gonzalo
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts accumulate genomic instability, but its underlying mechanisms and contribution to disease remain poorly understood. Here, we show that progerin-induced replication stress (RS) drives genomic instability by eliciting replication fork (RF) stalling and nuclease-mediated degradation. Rampant RS is accompanied by upregulation of the cGAS/STING cytosolic DNA sensing pathway and activation of a robust STAT1-regulated interferon (IFN)-like response...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29465830/toll-like-receptor-3-signal-augments-radiation-induced-tumor-growth-retardation-in-a-murine-model
#7
Sumito Yoshida, Hiroaki Shime, Yohei Takeda, Jin-Min Nam, Ken Takashima, Misako Matsumoto, Hiroki Shirato, Masanori Kasahara, Tsukasa Seya
Radiotherapy induces anti-tumor immunity by induction of tumor antigens and damage-associated molecular patterns (DAMPs). DNA, a representative DAMP in radiotherapy, activates the STING pathway which enhances the immune response. However, the immune response does not always parallel the inflammation associated with radiotherapy. This lack of correspondence may in part explain the radiation-resistance of tumors. Additive immunotherapy is expected to revive tumor-specific CTLs facilitating radiation-resistant tumor shrinkage...
February 21, 2018: Cancer Science
https://www.readbyqxmd.com/read/29462223/efficacy-safety-and-tolerability-of-topical-dapsone-gel-7-5-for-treatment-of-acne-vulgaris-by-fitzpatrick-skin-phototype
#8
Susan C Taylor, Fran E Cook-Bolden, Amy McMichael, Jeanine B Downie, David A Rodriguez, Andrew F Alexis, Valerie D Callender, Nancy Alvandi
BACKGROUND: Acne vulgaris (acne) is prevalent in individuals with skin of color, often with more frequent sequelae than in patients with lighter skin color. It is important to determine if there are also differences in response to medications. OBJECTIVE: This study evaluated the efficacy and tolerability of once-daily dapsone gel, 7.5% in patients with acne, stratified by Fitzpatrick skin phototype. METHODS: Data were pooled from 2 identically designed, phase 3, randomized, double-blind, vehicle-controlled studies in patients aged 12 years and older with moderate acne...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29459647/life-history-and-biocontrol-potential-of-the-first-female-producing-parthenogenetic-species-of-diglyphus-hymenoptera-eulophidae-against-agromyzid-leafminers
#9
Fu-Yu Ye, Chao-Dong Zhu, Zoya Yefremova, Wan-Xue Liu, Jian-Yang Guo, Fang-Hao Wan
Diglyphus species are dominant biocontrol agents for suppressing outbreaks of agromyzid leafminers in fields. In July 2015, we collected a new thelytokous species of Diglyphus in Qinghai, China. The wasp is here named as D. wani Liu, Zhu & Yefremova sp. nov., based on morphological and molecular analyses. The life history and biocontrol potential of the wasp were studied in the laboratory and by providing Liriomyza sativae larvae. The intrinsic rate of increase, finite rate of increase, and mean generation time were 0...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29456253/delicate-regulation-of-the-cgas-mita-mediated-innate-immune-response
#10
REVIEW
Wei-Wei Luo, Hong-Bing Shu
Although it has long been demonstrated that cytosolic DNA is a potent immune stimulant, it is only in recent years that the molecular mechanisms of DNA-stimulated innate immune responses have emerged. Studies have established critical roles for the DNA sensor cyclic GMP-AMP synthase (cGAS) and the adapter protein MITA/STING in the innate immune response to cytosolic DNA or DNA viruses. Although the regulation of cGAS-MITA/STING-mediated signaling remains to be fully investigated, understanding the processes involved may help to explain the mechanisms of innate immune signaling events and perhaps autoinflammatory diseases and to provide potential therapeutic targets for drug intervention...
February 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#11
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29449905/searching-for-silver-linings-is-perceived-medical-discrimination-weaker-in-segregated-areas
#12
Joseph Gibbons, Tse-Chuan Yang
An ongoing obstacle in dealing with minority health disparities is discriminatory behavior from healthcare practitioners, also known as medical discrimination. It is not clear, however, if the effects of medical discriminations onto health are constant across space. For example, there is evidence to suspect minorities in racially segregated neighborhoods suffer less from discrimination compared to those living elsewhere. To determine the presence of spatial heterogeneity underlying medical discrimination, we implement logistic geographically weighted regression (GWR) using individual data in the city of Philadelphia from the 2006 and 2008 Public Health Management Corporation's Southeastern Pennsylvania Household Health Surveys...
March 2018: Applied Spatial Analysis and Policy
https://www.readbyqxmd.com/read/29447986/research-progress-of-cgas-sting-pathway-in-infectious-diseases
#13
REVIEW
Xiaohu Wang, Chuntao Liu
Infectious diseases pose a serious threat to human health. cGAS is a newly discovered nucleic acid transferase in recent years, which can identify cytoplasmic DNA and produce an endogenous cyclic dinucleotide cGAMP to activate STING. It is found that the cGAS-STING pathway plays an important role in the body's resistance to microbe infection. This article reviews the recent progress of cGAS-STING pathway in infectious diseases.
February 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29447950/ethnobotanical-and-ethnomedicinal-studies-in-baluchi-tribes-a-case-study-in-mt-taftan-southeastern-iran
#14
Tahereh Maleki, Hossein Akhani
ETHNOBOTANICAL RELEVANCE: From ancient times, the applied use of herbs has been common among indigenous people throughout the world. The present survey is a regional ethnobotanical study of Baluchi tribes living in the Mt. Taftan area, Sistan and Baluchistan Province, southeastern Iran. The aim of this study was to document all traditional knowledge and analyze the medicinal plants used in area and also to identify significant plant species for future pharmacological study. MATERIALS AND METHODS: Local knowledge was obtained through semi structured and open interviews, in which 51 informants were interviewed...
February 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29447250/correction-sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#15
Jason R Baird, Zipei Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
[This corrects the article DOI: 10.1371/journal.pone.0187532.].
2018: PloS One
https://www.readbyqxmd.com/read/29446653/cgas-mediated-autophagy-protects-the-liver-from-ischemia-reperfusion-injury-independent-of-sting
#16
Zhao Lei, Meihong Deng, Zhongjie Yi, Qian Sun, Richard A Shapiro, Hongbo Xu, Tunliang Li, Patricia A Loughran, John E Griepentrog, Hai Huang, Melanie J Scott, Feizhou Huang, Timothy R Billiar
Liver ischemia/reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor known to trigger stimulator of interferon genes (STING) and downstream type1 interferon (IFN-I) pathways, which are pivotal innate immune system responses to pathogen. However, little is known about the role of cGAS/STING in liver I/R injury...
February 15, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29441146/-vespa-crabro-immunotherapy-versus-vespula-venom-immunotherapy-in-vespa-crabro-allergy-a-comparison-study-in-field-re-stings
#17
Donatella Macchia, Gabriele Cortellini, Marina Mauro, Elisa Meucci, Oliviero Quercia, Mariangela Manfredi, Alessandro Massolo, Maurizio Valentini, Maurizio Severino, Giovanni Passalacqua
Background: In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. However, antigen 5 immunoblotting studies showed that a genuine sensitization to VC venom may exist. In such cases, a specific VC venom would be preferable for VIT treatment. Since in the last few years, VC venom extracts became available for diagnosis and desensitization, we assessed the efficacy and safety of VIT with a VC-VIT, compared to VE extract...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29440426/sting-dependent-translation-inhibition-restricts-rna-virus-replication
#18
Kate M Franz, William J Neidermyer, Yee-Joo Tan, Sean P J Whelan, Jonathan C Kagan
In mammalian cells, IFN responses that occur during RNA and DNA virus infections are activated by distinct signaling pathways. The RIG-I-like-receptors (RLRs) bind viral RNA and engage the adaptor MAVS (mitochondrial antiviral signaling) to promote IFN expression, whereas cGAS (cGMP-AMP synthase) binds viral DNA and activates an analogous pathway via the protein STING (stimulator of IFN genes). In this study, we confirm that STING is not necessary to induce IFN expression during RNA virus infection but also find that STING is required to restrict the replication of diverse RNA viruses...
February 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29431896/on-taking-the-sting-out-of-immune-activation
#19
REVIEW
Andra Banete, Kyle Seaver, Devyani Bakshi, Katrina Gee, Sameh Basta
Nearly a decade ago, an endoplasmic reticulum (ER) adaptor protein called stimulator of interferon genes (STING) was found to be critical in the induction of type I IFN production in response to DNA virus infection. STING functions by sensing cytoplasmic DNA and activates key transcription factors, including IFN regulatory factor (IRF)-3 and IRF7, to initiate type I IFN expression. Type I IFNs are vital in immunity against viral infections and can influence cancer cell proliferation, migration, and apoptosis...
February 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29428915/second-dose-of-scorpion-antivenom-in-children-with-indian-red-scorpion-mesobuthus-tamulus-sting-envenomation
#20
Anitha Abimannane, Ramachandran Rameshkumar, Ponnarmeni Satheesh, Subramanian Mahadevan
OBJECTIVE: To study the effect of the second dose of scorpion antivenom in children with non-resolving or worsening scorpion sting envenomation. METHODS: 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation at 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied...
February 9, 2018: Indian Pediatrics
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