David A Siegel, Cassandra Thanh, Eunice Wan, Rebecca Hoh, Kristen Hobbs, Tony Pan, Erica A Gibson, Deanna L Kroetz, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Maureen Martin, Mary Carrington, Satish Pillai, Michael P Busch, Mars Stone, Claire N Levy, Meei-Li Huang, Pavitra Roychoudhury, Florian Hladik, Keith R Jerome, Hans-Peter Kiem, Timothy J Henrich, Steven G Deeks, Sulggi A Lee
OBJECTIVE: Prior genomewide association studies have identified variation in major histocompatibility complex (MHC) class I alleles and C-C chemokine receptor type 5 gene (CCR5Δ32) as genetic predictors of viral control, especially in 'elite' controllers, individuals who remain virally suppressed in the absence of therapy. DESIGN: Cross-sectional genomewide association study. METHODS: We analyzed custom whole exome sequencing and direct human leukocyte antigen (HLA) typing from 202 antiretroviral therapy (ART)-suppressed HIV+ noncontrollers in relation to four measures of the peripheral CD4+ T-cell reservoir: HIV intact DNA, total (t)DNA, unspliced (us)RNA, and RNA/DNA...
March 1, 2023: AIDS