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https://www.readbyqxmd.com/read/28820953/a-fluorescence-based-high-throughput-assay-for-the-identification-of-anticancer-reagents-targeting-fructose-1-6-bisphosphate-aldolase
#1
Eun Jeong Cho, Ashwini K Devkota, Gabriel Stancu, Ramakrishna Edupunganti, Garth Powis, Kevin N Dalby
A high rate of glycolysis, which supplies energy and materials for anabolism, is observed in a wide range of tumor cells, making it a potential pathway to control cancer growth. ALDOA is a multifunctional enzyme in the glycolytic pathway and also promotes HIF-1α, which is of importance in hypoxic solid tumors. The current method for assaying ALDOA activity involves monitoring the consumption of NADH in vitro using absorbance or intrinsic fluorescence via a coupled enzymatic reaction. Here, we report the development of a homogeneous biochemical assay that can overcome limitations of current methods, in particular for the application of high-throughput drug screening...
August 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28816171/effect-of-magnesium-supplementation-on-muscular-damage-markers-in-basketball-players-during-a-full-season
#2
Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García
Although it has been widely accepted that Mg has a positive effect on muscle function, studies on the efficacy of Mg supplementation in young athletes have generated contrasting results. The aim of this work was to examine the effect of Mg supplementation on muscular damage markers and the association between serum Mg levels with these muscular markers. Twelve elite male basketball players (PB) from a team of Spanish Professional Basketball League and a control group (CG) comprising twelve university students who practiced regularly recreational basketball and competed in minor university leagues participated in this study...
August 17, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28815371/-side-effects-of-modernity-dam-building-health-care-and-the-construction-of-power-in-the-context-of-the-control-of-schistosomiasis-in-egypt-in-the-1960s-and-early-1970s
#3
Benjamin Brendel
This article analyzes the modernization campaigns in Egypt in the 1960s and early 1970s. The regulation of the Nile by the Aswan High Dam and the resulting irrigation projects caused the rate of schistosomiasis infestation in the population to rise. The result was a discourse between experts from the global north and Egyptian elites about modernization, development aid, dam building and health care. The fight against schistosomiasis was like a cipher, which combined different power-laden concepts and arguments...
August 16, 2017: NTM
https://www.readbyqxmd.com/read/28815018/serum-complexed-and-free-prostate-specific-antigen-levels-are-lower-in-female-elite-athletes-in-comparison-to-control-women
#4
Emma Eklund, Eleftherios P Diamandis, Carla Muytjens, Sarah Wheeler, Anu Mathew, Martin Stengelin, Eli Glezer, Galina Nikolenko, Marshall D Brown, Yingye Zheng, Angelica Lindén Hirschberg
BACKGROUND: We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women. METHODS: We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls.  Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively...
2017: F1000Research
https://www.readbyqxmd.com/read/28814702/reorganizing-hospital-space-the-1894-plague-epidemic-in-hong-kong-and-the-germ-theory
#5
Kyu-Hwan Sihn
This paper examined whether the preventive measures taken by the Hong Kong's colonial authorities were legitimate during the 1894 Hong Kong plague epidemic, and illuminated the correlation between the plague epidemic and hospital space in Hong Kong in the late 19th century. The quarantine measures taken by the colonial authorities were neither a clear-cut victory for Western medicine nor for a rational quarantine based on scientific medical knowledge. Hong Kong's medical officials based on the miasma theory, and focused only on house-to-house inspections and forced quarantine or isolation, without encouraging people to wear masks and without conducting disinfection...
April 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28806100/including-the-copenhagen-adduction-exercise-in-the-fifa-11-provides-missing-eccentric-hip-adduction-strength-effect-in-male-soccer-players-a-randomized-controlled-trial
#6
Joar Harøy, Kristian Thorborg, Andreas Serner, André Bjørkheim, Linn E Rolstad, Per Hölmich, Roald Bahr, Thor Einar Andersen
BACKGROUND: The FIFA 11+ was developed as a complete warm-up program to prevent injuries in soccer players. Although reduced hip adduction strength is associated with groin injuries, none of the exercises included in the FIFA 11+ seem to specifically target hip adduction strength. PURPOSE: To investigate the effect on eccentric hip adduction strength of the FIFA 11+ warm-up program with or without the Copenhagen adduction exercise. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28799906/of-mice-macaques-and-men-broadly-neutralizing-antibody-immunotherapy-for-hiv-1
#7
REVIEW
Yoshiaki Nishimura, Malcolm A Martin
The neutralizing antibodies targeting the HIV-1 envelope protein have been a major focus for HIV therapy. Early studies with anti-HIV-1 neutralizing monoclonal antibodies (mAbs) administered to infected individuals showed some promise, as they resulted in transient reductions in plasma viremia in some recipients. However, resistant viral variants rapidly emerged. A major development during the past 6 to 7 years has been the isolation and characterization of highly potent and broadly neutralizing mAbs (bNAbs) from infected individuals known as "elite neutralizers...
August 9, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28799866/proprioception-and-flexibility-profiles-of-elite-synchronized-swimmers
#8
Nora M Y Cho, Hedda P Giorgi, Karen P Y Liu, Young-Hyeon Bae, Louisa M Y Chung, Kitchana Kaewkaen, Shirley S M Fong
This study compared the full-body flexibility and joint proprioception (on land and underwater) of (a) 20 elite female synchronized swimmers (mean age ± standard deviation = 18.5 ± 1.9 years) and (b) 20 college female swim team members with no training in synchronized swimming (control participants; mean age ± standard deviation = 20.6 ± 1.3 years). Flexibility of the trunk and upper and lower limbs was measured using plastic tape and a goniometer, respectively. Joint proprioception (joint position sense) of the upper and lower limbs on land and underwater was measured by an active joint angle repositioning test...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28782910/eucapnic-voluntary-hyperventilation-test-in-children
#9
Janne Burman, Heikki Lukkarinen, Varpu Elenius, Sami Remes, Tom Kuusela, Tuomas Jartti
BACKGROUND: In children, exercise-induced dyspnea is a common symptom that can be due to dysfunctional breathing. EVH test has bee used especially in elite athletes as bronchoprovocation test. Currently, there are only few studies on the EVH test. New research methods are required alongside the traditionally used tests especially due to dysfunctional breathing disorder. PURPOSE: The purpose of the "pilot study" was to study the usability of the EVH test with real time biofeedback in children of 10-16 years of age in the diagnostics of exercise-induced dyspnea...
August 7, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28780586/is-there-an-optimum-level-of-diversity-in-utilization-of-genetic-resources
#10
Manfred Mayer, Sandra Unterseer, Eva Bauer, Natalia de Leon, Bernardo Ordas, Chris-Carolin Schön
Capitalizing upon the genomic characteristics of long-term random mating populations, sampling from pre-selected landraces is a promising approach for broadening the genetic base of elite germplasm for quantitative traits. Genome-enabled strategies for harnessing untapped allelic variation of landraces are currently evolving. The success of such approaches depends on the choice of source material. Thus, the analysis of different strategies for sampling allelic variation from landraces and their impact on population diversity and linkage disequilibrium (LD) is required to ensure the efficient utilization of diversity...
August 5, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28768893/performance-trade-offs-and-ageing-in-the-world-s-greatest-athletes
#11
Vincent Careau, Robbie S Wilson
The mechanistic foundations of performance trade-offs are clear: because body size and shape constrains movement, and muscles vary in strength and fibre type, certain physical traits should act in opposition with others (e.g. sprint versus endurance). Yet performance trade-offs are rarely detected, and traits are often positively correlated. A potential resolution to this conundrum is that within-individual performance trade-offs can be masked by among-individual variation in 'quality'. Although there is a current debate on how to unambiguously define and account for quality, no previous studies have partitioned trait correlations at the within- and among-individual levels...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28761702/static-stretching-does-not-enhance-recovery-in-elite-youth-soccer-players
#12
Sam Pooley, Owen Spendiff, Matt Allen, Hannah J Moir
BACKGROUND: Static stretching (SS) is a recovery intervention used for the reduction of muscle soreness postexercise. The effects of SS on elite young footballers have received little attention, and therefore the aim of this study was to assess the effects of SS on muscle recovery following competitive soccer matches in elite young footballers. METHODS: Ten male participants (16±1 years) were recruited from an English Premier League professional soccer academy...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28749699/patellofemoral-joint-loads-during-running-at-the-time-of-return-to-sport-in-elite-athletes-with-acl-reconstruction
#13
Lee Herrington, Saud Alarifi, Richard Jones
BACKGROUND: Patellofemoral joint pain and degeneration are common in patients who undergo anterior cruciate ligament reconstruction (ACLR). The presence of patellofemoral joint pain significantly affects the patient's ability to continue sport participation and may even affect participation in activities of daily living. The mechanisms behind patellofemoral joint pain and degeneration are unclear, but previous research has identified altered patellofemoral joint loading in individuals with patellofemoral joint pain when running...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28748664/long-term-efficient-control-of-siv-infection-in-macaques-is-associated-with-an-intact-intestinal-barrier
#14
Maria Daskalaki, Berit Neumann, Antonina Klippert, Kerstin Mätz-Rensing, Franz-Josef Kaup, Christiane Stahl-Hennig
Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing controllers, elite controllers show preserved CD4 T cells, and low viral load, apoptosis, and inflammation.
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28740260/richer-gut-microbiota-with-distinct-metabolic-profile-in-hiv-infected-elite-controllers
#15
Jan Vesterbacka, Javier Rivera, Kajsa Noyan, Mariona Parera, Ujjwal Neogi, Malu Calle, Roger Paredes, Anders Sönnerborg, Marc Noguera-Julian, Piotr Nowak
Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal microbiota were significantly higher in EC versus naive. Genera Succinivibrio, Sutterella, Rhizobium, Delftia, Anaerofilum and Oscillospira were more abundant in EC, whereas Blautia and Anaerostipes were depleted...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738681/optimizing-high-resolution-mass-spectrometry-for-the-identification-of-low-abundance-post-translational-modifications-of-intact-proteins
#16
Lisa E Kilpatrick, Eric L Kilpatrick
Intact protein analysis by liquid chromatography-mass spectrometry (LC-MS) is now possible due to the improved capabilities of mass spectrometers yielding greater resolution, mass accuracy, and extended mass ranges. Concurrent measurement of post-translational modifications (PTMs) during LC-MS of intact proteins is advantageous while monitoring critical proteoform status, such as for clinical samples or during production of reference materials. However, difficulties exist for PTM identification when the protein is large or contains multiple modification sites...
August 8, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28738670/antidoping-program-an-important-factor-in-the-promotion-and-protection-of-the-integrity-of-sport-and-athlete-s-health
#17
Filomena Mazzeo, Vincenzo Monda, Stefania Santamaria, Ersilia Nigro, Anna Valenzano, Ines Villano, Giuseppe Cibelli, Antonietta Messina, Giovanni Messina
Use of performance-enhancing drugs concern not only elite Olympic and Paralympic Games' athletes but also amateur athletes, who are making increasing use of substances and/or methods. Furthermore, a new frontier reached by the doping is the use of genes. World Anti- Doping Agency (WADA), expressly prohibited the participation in competitive sports by the athlete in case of taking banned substances to treat disease in the event that the above assumption implies an excessive improvement of performance. This study aims to analyze and show the doping control as an essential part of the anti-doping program to promote and protect the integrity of sport and athlete's health...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28730463/exploring-new-alleles-for-frost-tolerance-in-winter-rye
#18
Wiltrud Erath, Eva Bauer, D Brian Fowler, Andres Gordillo, Viktor Korzun, Mira Ponomareva, Malthe Schmidt, Brigitta Schmiedchen, Peer Wilde, Chris-Carolin Schön
Rye genetic resources provide a valuable source of new alleles for the improvement of frost tolerance in rye breeding programs. Frost tolerance is a must-have trait for winter cereal production in northern and continental cropping areas. Genetic resources should harbor promising alleles for the improvement of frost tolerance of winter rye elite lines. For frost tolerance breeding, the identification of quantitative trait loci (QTL) and the choice of optimum genome-based selection methods are essential. We identified genomic regions involved in frost tolerance of winter rye by QTL mapping in a biparental population derived from a highly frost tolerant selection from the Canadian cultivar Puma and the European elite line Lo157...
July 20, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28720421/assessment-of-the-hiv-1-reservoir-in-cd4-regulatory-t-cells-by-a-droplet-digital-pcr-based-approach
#19
Gábor Artúr Dunay, Anastasia Solomatina, Silke Kummer, Anja Hüfner, Julia Katharina Bialek, Johanna Maria Eberhard, Eva Tolosa, Joachim Hauber, Julian Schulze Zur Wiesch
The relative contribution of regulatory T cells (Treg) as reservoir of HIV-1 in patients on chronic antiretroviral therapy is unclear to date. The aim of the current study was to assess the total HIV DNA burden and replication competent viral reservoir in Treg in comparison to central and effector memory cells (Tcm and Tem). Peripheral blood mononuclear cells were obtained from 10 HIV patients treated with antiretroviral therapy and one HIV elite controller. Droplet Digital PCR (ddPCR) was used to quantify total HIV DNA loads in FACS sorted CD4+ Treg (CD25+CD127lo) as compared with Tcm (CD45RO+CCR7+) and Tem (CD45RO+CCR7-)...
July 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28714759/effects-of-rigid-and-kinesio-taping-on-shoulder-rotation-motions-posterior-shoulder-tightness-and-posture-in-asymptomatic-overhead-athletes-a-randomized-controlled-trial
#20
Damla Gulpinar, Sibel Tekeli Ozer, Sevgi S Yesilyaprak
CONTEXT: Alterations in posture and motion patterns are thought to play a role in developing shoulder injuries in overhead athletes. Taping is widely used in the sporting population, but there are limited empirical data regarding its effectiveness. OBJECTIVES: To determine and compare the effects of rigid and kinesio taping on shoulder rotation motions, posterior shoulder tightness (PST) and posture in overhead athletes. DESIGN: Randomized controlled trial...
July 17, 2017: Journal of Sport Rehabilitation
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