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https://www.readbyqxmd.com/read/28225449/ifn-%C3%AE-augments-natural-killer-mediated-antibody-dependent-cellular-cytotoxicity-of-hiv-1-infected-autologous-cd4-t-cells-regardless-of-major-histocompatibility-complex-class-1-downregulation
#1
Costin Tomescu, Pablo Tebas, Luis J Montaner
DESIGN: We have previously shown that IFN-α stimulation augments direct natural killer (NK) cell lysis of autologous CD4 primary T cells infected with certain HIV-1 isolates based upon major histocompatibility complex class 1 (MHC-1) downregulation capacity. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC) could trigger lysis of HIV-1 isolates that were resistant to direct NK lysis and if IFN-α prestimulation of NK cells could further enhance ADCC. METHODS: Using broadly neutralizing monoclonal antibodies against gp120 (VRC01 or PGV04) or plasma from HIV-1-infected patients (ART-suppressed or elite controller) to trigger ADCC, we measured NK cell chromium release cytotoxicity against HIV-1-infected autologous CD4 primary T cells and NK cell CD107a degranulation against gp120-coated CD4 T cells...
March 13, 2017: AIDS
https://www.readbyqxmd.com/read/28223305/eighty-three-per-cent-of-elite-athletes-return-to-preinjury-sport-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-with-meta-analysis-of-return-to-sport-rates-graft-rupture-rates-and-performance-outcomes
#2
REVIEW
Courtney C H Lai, Clare L Ardern, Julian A Feller, Kate E Webster
OBJECTIVES: The primary objective was to calculate the rate of return to sport (RTS) following anterior cruciate ligament (ACL) reconstruction in elite athletes. Secondary objectives were to estimate the time taken to RTS, calculate rates of ACL graft rupture, evaluate postsurgical athletic performance and identify determinants of RTS. DESIGN: Pooled RTS and graft rupture rates were calculated using random effects proportion meta-analysis. Time to RTS, performance data and determinants of RTS were synthesised descriptively...
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28220500/neuroplus-biofeedback-improves-attention-resilience-and-injury-prevention-in-elite-soccer-players
#3
Aiace Rusciano, Giuliano Corradini, Ivilin Stoianov
Performance and injury prevention in elite soccer players are typically investigated from physical-tactical, biomechanical, and metabolic perspectives. However, executive functions, visuospatial abilities, and psychophysiological adaptability or resilience are also fundamental for efficiency and well-being in sports. Based on previous research associating autonomic flexibility with prefrontal cortical control, we designed a novel integrated autonomic biofeedback training method called Neuroplus to improve resilience, visual attention, and injury prevention...
February 21, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28213178/the-atypical-excretion-profile-of-meldonium-comparison-of-urinary-detection-windows-after-single-and-multiple-dose-application-in-healthy-volunteers
#4
Christian Görgens, Sven Guddat, Christina Bosse, Hans Geyer, Valentin Pop, Wilhelm Schänzer, Mario Thevis
Following a one-year monitoring program providing unequivocal analytical evidence for a high prevalence in international elite sports, meldonium has been included in the World Anti-Doping Agency's (WADA) list of prohibited substances that came into effect on 1 January 2016. Despite of the polar and hydrophilic nature of the molecule, an unusual long detection window was observed in pilot elimination studies. Consequently, in the present study, urinary excretion profiles after single-dose (5 volunteers, 1×500mg) and multiple-dose oral application (5 volunteers; 2×500mg/day for 6days) were determined in order to facilitate the result management concerning meldonium findings in doping controls...
February 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28211903/activating-killer-immunoglobulin-receptors-and-hla-c-a-successful-combination-providing-hiv-1-control
#5
Mauro S Malnati, Elisabetta Ugolotti, Maria Cristina Monti, Davide De Battista, Irene Vanni, Domenico Bordo, Francesca Sironi, Patrizia Larghero, Eddi Di Marco, Priscilla Biswas, Guido Poli, Elisa Vicenzi, Agostino Riva, Maciej Tarkowski, Giuseppe Tambussi, Silvia Nozza, Gino Tripodi, Francesco Marras, Andrea De Maria, Angela Pistorio, Roberto Biassoni
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210347/assessing-cognitive-performance-in-badminton-players-a-reproducibility-and-validity-study
#6
Tanja van de Water, Barbara Huijgen, Irene Faber, Marije Elferink-Gemser
Fast reaction and good inhibitory control are associated with elite sports performance. To evaluate the reproducibility and validity of a newly developed Badminton Reaction Inhibition Test (BRIT), fifteen elite (25 ± 4 years) and nine non-elite (24 ± 4 years) Dutch male badminton players participated in the study. The BRIT measured four components: domain-general reaction time, badminton-specific reaction time, domain-general inhibitory control and badminton-specific inhibitory control. Five participants were retested within three weeks on the badminton-specific components...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210346/mental-toughness-in-talented-youth-tennis-players-a-comparison-between-on-court-observations-and-a-self-reported-measure
#7
Ruben Houwer, Tamara Kramer, Ruud den Hartigh, Nikki Kolman, Marije Elferink-Gemser, Barbara Huijgen
In tennis, mental toughness is often considered highly important in achieving the elite level. The current study is the first to examine behavioural expressions of mental toughness on the court and their relationships with self-reported measures. Based on the input of five experienced tennis coaches of junior tennis players and behaviours used in previous studies, we developed a taxonomy consisting of six positive behaviours and ten negative ones. To investigate the relationship between these on-court behaviours of mental toughness and how the players rated their own mental toughness, emotional control in particular, six talented tennis players (aged 10-13) were recorded during tennis matches and filled out the self-reported measure of mental toughness (MTQ48)...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28197695/rotational-glenohumeral-adaptations-are-associated-with-shoulder-pathology-in-professional-male-handball-players
#8
Przemyslaw Lubiatowski, Piotr Kaczmarek, Pawel Cisowski, Ewa Breborowicz, Monika Grygorowicz, Marcin Dzianach, Tomasz Krupecki, Lior Laver, Leszek Romanowski
PURPOSE: Glenohumeral range of motion adaptations may affect throwing athletes and contribute to shoulder injury. The purpose of this study was to evaluate shoulder rotation deficits among elite professional handball players and its correlation to the presence of shoulder pain and morphological changes. METHODS: Eighty-seven elite professional handball players and 41 healthy non-athlete volunteers participated in the study. Evaluations included measurement of range of internal and external rotation, total arch of motion, identification of shoulder pain and ultrasound scan for diagnosis of rotator cuff tears and internal impingement...
February 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28194116/dynamic-and-static-exercises-differentially-affect-plasma-cytokine-content-in-elite-endurance-and-strength-trained-athletes-and-untrained-volunteers
#9
Leonid V Kapilevich, Anna N Zakharova, Anastasia V Kabachkova, Tatyana A Kironenko, Sergei N Orlov
Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training interventions on cytokine production remains poorly defined. In this study, we compared effects of dynamic and static load on cytokine plasma content in elite strength- and endurance-trained athletes vs. healthy untrained volunteers. The plasma cytokine content was measured before, immediately after, and 30 min post-exercise using enzyme-linked immunosorbent assay...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28193736/down-regulation-of-cd73-on-b-cells-of-patients-with-viremic-hiv-correlates-with-b-cell-activation-and-disease-progression
#10
Eun-Seong Kim, Christin Ackermann, Ilona Tóth, Patrick Dierks, Johanna M Eberhard, Raluca Wroblewski, Felix Scherg, Matthias Geyer, Reinhold E Schmidt, Claudia Beisel, Maximilian Bockhorn, Friedrich Haag, Jan van Lunzen, Julian Schulze Zur Wiesch
Recently, alterations of the T cell expression of the ectonucleotidases, CD39 and CD73, during HIV infection have been described. Here, peripheral (n = 70) and lymph nodal B cells (n = 10) of patients with HIV at different stages of disease as well as uninfected individuals were analyzed via multicolor flow cytometry with regard to expression of CD39 and CD73 and differentiation, proliferation, and exhaustion status. Patients with chronic, untreated HIV showed a significantly decreased frequency of CD73-expressing B cells (P < 0...
February 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28190980/effect-of-low-dose-short-term-creatine-supplementation-on-muscle-power-output-in-elite-youth-soccer-players
#11
Aquiles Yáñez-Silva, Cosme F Buzzachera, Ivan Da C Piçarro, Renata S B Januario, Luis H B Ferreira, Steven R McAnulty, Alan C Utter, Tacito P Souza-Junior
BACKGROUND: To determine the effects of a low dose, short-term Creatine monohydrate (Cr) supplementation (0.03 g.kg.d(-1) during 14 d) on muscle power output in elite youth soccer players. METHODS: Using a two-group matched, double blind, placebo-controlled design, nineteen male soccer players (mean age = 17.0 ± 0.5 years) were randomly assigned to either Cr (N = 9) or placebo (N = 10) group. Before and after supplementation, participants performed a 30s Wingate Anaerobic Test (WAnT) to assess peak power output (PPO), mean power output (MPO), fatigue index (FI), and total work...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28182614/similar-immunological-profiles-between-nonprogressing-hiv-infection-in-children-and-nonpathogenic-siv-infection
#12
Eva Poveda, Enrique Martin-Gayo
In the absence of antirretroviral therapy (ART), HIV infection leads to progression to AIDS in most infected individuals. However, there is a small group of HIV-infected patients capable of spontaneously controlling HIV infection, known as the elite controllers (less than 1% of total infected population). These patients maintain undetectable levels of HIV replication, in part, due to a continuously effective HIV specific T cell response. Moreover, in HIV-infected patients with suppressed viremia under ART, a chronic activation of the immune system persist, which can be related to a poor clinical outcome including death, development of co-morbidities, AIDS and non-AIDS defining events...
January 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28179910/temporally-and-genetically-discrete-periods-of-wheat-sensitivity-to-high-temperature
#13
Henry M Barber, Martin Lukac, James Simmonds, Mikhail A Semenov, Mike J Gooding
Successive single day transfers of pot-grown wheat to high temperature (35/30°C day/night) replicated controlled environments, from the second node detectable to the milky-ripe growth stages, provides the strongest available evidence that the fertility of wheat can be highly vulnerable to heat stress during two discrete peak periods of susceptibility: early booting [decimal growth stage (GS) 41-45] and early anthesis (GS 61-65). A double Gaussian fitted simultaneously to grain number and weight data from two contrasting elite lines (Renesansa, listed in Serbia, Ppd-D1a, Rht8; Savannah, listed in UK, Ppd-D1b, Rht-D1b) identified peak periods of main stem susceptibility centered on 3 (s...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28178738/core-executive-functions-are-associated-with-success-in-young-elite-soccer-players
#14
Torbjörn Vestberg, Gustaf Reinebo, Liselotte Maurex, Martin Ingvar, Predrag Petrovic
Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, and it has been suggested that executive functions (EF) are fundamentally important for success in soccer. However, executive functions are going through a steep development from adolescence to adulthood. Moreover, more complex EF involving manipulation of information (higher level EF) develop later than simple executive functions such as those linked to simple working memory capacity (Core EF)...
2017: PloS One
https://www.readbyqxmd.com/read/28174513/cervical-mucus-proteome-in-endometriosis
#15
Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola, Riccardo Marana
BACKGROUND: Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7-10% of women of reproductive age and up to 50% of women with infertility. The current gold standard for the diagnosis combines laparoscopic evaluation and biopsy of the visualized lesions. However, laparoscopy requires general anesthesia and developed surgical skills and it has a high procedural cost...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28174008/setting-characteristics-and-mechanical-properties-of-self-adhesive-resin-luting-agents
#16
Raphael Pilo, Dimitris Papadogiannis, Spiros Zinelis, George Eliades
OBJECTIVE: To evaluate the degree of conversion (DC%), salt yield and mechanical properties of self-adhesive luting agents (SAA) set under dual-cure (E) and self-cure (NE) modes. METHODS: Three SAA (GC LinkAce/GCLA, MaxCem Elite/MXEL, Rely-X Unicem 2/RXUN) and an adhesive resin luting agent (Rely-X Ultimate/RXUL-control) were used. The properties tested under E and NE modes were a) DC% and phosphate salt yield after 10min, 1h (h) and 3 weeks (w) storage, by infrared spectroscopy; and b) the mechanical properties of 3w-stored specimens by instrumented indentation testing (Martens hardness/HM, Elastic modulus/EIT, Elastic index/ηIT) and microscopic Vickers hardness/VH...
February 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28163595/identification-of-a-low-tiller-gene-from-a-new-plant-type-cultivar-in-rice-oryza-sativa-l
#17
Md Nashir Uddin, Asami Tomita, Mitsuhiro Obara, Seiji Yanagihara, Yoshimichi Fukuta
We characterized a rice introgression line, YTH34, harboring a chromosome segment from a New Plant Type (NPT) cultivar, IR65600-87-2-2-3, in the genetic background of an Indica Group elite rice cultivar, IR 64, under upland and irrigated lowland conditions in Japan. The number of panicles (as an indicator of tiller number) and number of spikelets per panicle of YTH34 were lower than those of IR 64 under irrigated lowland conditions, but both of those as well as culm length, panicle length, seed fertility, panicle weight, whole plant weight, and harvest index were dramatically reduced under upland conditions...
December 2016: Breeding Science
https://www.readbyqxmd.com/read/28152692/pathway-map-development-as-an-approach-to-identifying-priority-areas-for-quality-improvement-in-ontario
#18
Jasmin Soobrian, Joan Murphy, Lorraine Elit, Michael F Milosevic, Angelika Gollnow, Jillian Ross, Claire Holloway
: 108 Background: Disease Pathway Management (DPM) is the unifying approach to the way in which Cancer Care Ontario (CCO) sets priorities for cancer control, plans cancer services and improves the quality of care in Ontario. In 2014 DPM began developing a cervical cancer pathway map (CCPM) to map the patient journey along the cervical cancer care continuum. OBJECTIVE: to report on the CPPM development process as a tool to identify key priorities for cervical cancer management in Ontario...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150471/the-effect-of-4-weeks-fixed-and-mixed-intermittent-hypoxic-training-iht-on-respiratory-metabolic-and-acid-base-response-of-capillary-blood-during-submaximal-bicycle-exercise-in-male-elite-taekwondo-players
#19
Hun-Young Park, Sub Sunoo, Sang-Seok Nam
Purpose: The purpose of our study was to determine the effectiveness of 4 weeks fixed and mixed intermittent hypoxic training (IHT) and its difference from exercise training at sea-level on exercise load, respiratory metabolic and acid-base response of capillary blood during 80% maximal heart rate (HRmax) bicycle exercise in male elite Taekwondo players. Methods: Male elite Taekwondo players (n = 25 out of 33) were randomly assigned to training at sea-level (n = 8, control group), training at 16...
December 31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28149523/differences-in-life-expectancy-between-olympic-high-jumpers-discus-throwers-marathon-and-100-meter-runners
#20
Jeffrey Lee-Heidenreich, David Lee-Heidenreich, Jonathan Myers
BACKGROUND: Several studies have demonstrated that body habitus is associated with survival (life expectancy) time. We sought to determine if survival differed between elite athletes with a range of body types. We hypothesized that the survival would differ between athlete types and that ectomorph athletes would have longer survival than heavier athletes. METHODS: For each Olympics between 1928 and 1948 we identified the top (up to 20) Olympic male and female finishers in the high jump (HJ), discus throw, marathon, and 100-m run...
2017: BMC Sports Science, Medicine and Rehabilitation
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