keyword
Keywords Circulating biomarkers AND ner...

Circulating biomarkers AND nervous system disease

https://read.qxmd.com/read/38514190/inflammation-biomarkers-in-the-intracranial-blood-are-associated-with-outcome-in-patients-with-ischemic-stroke
#1
JOURNAL ARTICLE
Cyril Dargazanli, Marine Blaquière, Marinette Moynier, Frédéric de Bock, Julien Labreuche, Adrien Ter Schiphorst, Imad Derraz, Răzvan Alexandru Radu, Gregory Gascou, Pierre Henri Lefevre, Francesca Rapido, Julien Fendeleur, Caroline Arquizan, Romain Bourcier, Philippe Marin, Paolo Machi, Federico Cagnazzo, Christophe Hirtz, Vincent Costalat, Nicola Marchi
BACKGROUND: Performing endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) allows a port of entry for intracranial biological sampling. OBJECTIVE: To test the hypothesis that specific immune players are molecular contributors to disease, outcome biomarkers, and potential targets for modifying AIS. METHODS: We examined 75 subjects presenting with large vessel occlusion of the anterior circulation and undergoing EVT. Intracranial blood samples were obtained by microcatheter aspiration, as positioned for stent deployment...
March 21, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38433020/human-umbilical-cord-mesenchymal-stem-cells-reverse-depression-in-rats-induced-by-chronic-unpredictable-mild-stress-combined-with-lipopolysaccharide
#2
JOURNAL ARTICLE
Pengxiang Wang, Yunxia Li, Yongli Song, Yuan Gao, Chunxia Hao, Yang Zhou, Siqin Bao, Jitong Guo, Xihe Li
BACKGROUND: Inflammation and oxidative stress are considered crucial to the pathogenesis of depression. Rat models of depression can be created by combined treatments of chronic unpredictable mild stress (CUMS) and lipopolysaccharide (LPS). Behaviors associated with depression could be improved by treatment with mesenchymal stem cells (MSCs) owing to immunomodulatory functions of the cells. Therapeutic potentials of the MSCs to reverse pro-inflammatory cytokines, proteins, and metabolites were identified by transcriptomic, proteomic, and metabolomic analysis, respectively...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38425927/development-of-a-fluorescently-labeled-ligand-for-rapid-detection-of-dat-in-human-and-mouse-peripheral-blood-monocytes
#3
JOURNAL ARTICLE
Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newman
The dopamine transporter (DAT) is one of the key regulators of dopamine (DA) signaling in the central nervous system (CNS) and in the periphery. Recent reports in a model of Parkinson's disease (PD) have shown that dopamine neuronal loss in the CNS impacts the expression of DAT in peripheral immune cells. The mechanism underlying this connection is still unclear but could be illuminated with sensitive and high-throughput detection of DAT-expressing immune cells in the circulation. Herein, we have developed fluorescently labeled ligands (FLL) that bind to surface-expressing DAT with high affinity and selectivity...
February 26, 2024: JACS Au
https://read.qxmd.com/read/38425361/plasma-neurofilament-light-chain-associated-with-impaired-regional-cerebral-blood-flow-in-healthy-individuals
#4
JOURNAL ARTICLE
Fardin Nabizadeh, Richard T Ward, Mohammad Balabandian, Samuel Berchi Kankam, Mahsa Pourhamzeh
Background: Recent findings suggest that the plasma axonal structural protein, neurofilament light (NFL) chain, may serve as a potential blood biomarker for early signs of neurodegenerative diseases, such as Alzheimer's disease (AD). Given the need for early detection of neurodegenerative disorders, the current study investigated the associations between regional cerebral blood flow (rCBF) in brain regions associated with neurodegenerative disorders and memory function with plasma NFL in AD, mild cognitive impairment (MCI), and healthy controls (HCs)...
October 7, 2023: Current journal of neurology
https://read.qxmd.com/read/38424741/increased-levels-of-circulating-soluble-cd226-in-multiple-sclerosis
#5
JOURNAL ARTICLE
Saniya Kari, Florence Bucciarelli, Thibault Angles, Anne-Cecile Oster, Pauline Cauboue, Karl Laviolette, Madeline Mougenot, Elena Morandi, Isabelle Bernard, Beatrice Pignolet, Chloé Bost, Joelle Thomas, Leonor Nogueira, Abdelhadi Saoudi, Roland Liblau, Anne L Astier
BACKGROUND: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown. OBJECTIVE: To investigate the presence and functional implications of sCD226 in persons with multiple sclerosis (pwMS) and other neurological diseases. METHODS: The mechanisms of sCD226 production were first investigated by analyzing CD226 surface expression levels and supernatants of CD3/CD226-coactivated T cells...
February 29, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38407050/beyond-csf-and-neuroimaging-assessment-evaluating-plasma-mir-145-5p-as-a-potential-biomarker-for-mild-cognitive-impairment-and-alzheimer-s-disease
#6
JOURNAL ARTICLE
Qingfeng Wen, Mandy Melissa Jane Wittens, Sebastiaan Engelborghs, Marcel H M van Herwijnen, Maria Tsamou, Erwin Roggen, Bert Smeets, Julian Krauskopf, Jacco Jan Briedé
Alzheimer's disease (AD) is the most common cause of dementia. New strategies for the early detection of MCI and sporadic AD are crucial for developing effective treatment options. Current techniques used for diagnosis of AD are invasive and/or expensive, so they are not suitable for population screening. Cerebrospinal fluid (CSF) biomarkers such as amyloid β1-42 (Aβ1-42), total tau (T-tau), and phosphorylated tau181 (P-tau181) levels are core biomarkers for early diagnosis of AD. Several studies have proposed the use of blood-circulating microRNAs (miRNAs) as potential novel early biomarkers for AD...
March 6, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38321854/study-protocol-of-the-hungarian-longitudinal-study-of-healthy-brain-aging-huba
#7
JOURNAL ARTICLE
Éva M Bankó, Béla Weiss, István Hevesi, Annamária Manga, Pál Vakli, Menta Havadi-Nagy, Rebeka Kelemen, Eszter Somogyi, István Homolya, Adél Bihari, Ádám Simon, Ádám Nárai, Krisztina Tóth, Noémi Báthori, Vivien Tomacsek, András Horváth, Anita Kamondi, Mihály Racsmány, Ádám Dénes, Péter Simor, Tibor Kovács, Petra Hermann, Zoltán Vidnyánszky
BACKGROUND AND PURPOSE: <p>Neuro&shy;cog&shy;nitive aging and the associated brain diseases impose a major social and economic burden. Therefore, substantial efforts have been put into revealing the lifestyle, the neurobiological and the genetic underpinnings of healthy neurocognitive aging. However, these studies take place almost exclusively in a limited number of highly-developed countries. Thus, it is an important open question to what extent their findings may generalize to neurocognitive aging in other, not yet investigated regions...
January 30, 2024: Ideggyógyászati Szemle
https://read.qxmd.com/read/38295557/biomarkers-of-mitochondrial-disorders
#8
REVIEW
Brian J Shayota
Mitochondrial diseases encompass a heterogeneous group of disorders with a wide range of clinical manifestations, most classically resulting in neurological, muscular, and metabolic abnormalities, but having the potential to affect any organ system. Over the years, substantial progress has been made in identifying and characterizing various biomarkers associated with mitochondrial diseases. This review summarizes the current knowledge of mitochondrial biomarkers based on a literature review and discusses the evidence behind their use in clinical practice...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38285244/iron-based-biomarkers-for-personalizing-pharmacological-ascorbate-therapy-in-glioblastoma-insights-from-a-phase-2-clinical-trial
#9
JOURNAL ARTICLE
M S Petronek, K L Bodeker, C Y Lee, N Teferi, K L Eschbacher, K A Jones, B T Loeffler, B J Smith, J M Buatti, V A Magnotta, B G Allen
BACKGROUND: Pharmacological ascorbate (intravenous delivery reaching plasma concentrations ≈ 20 mM; P-AscH- ) has emerged as a promising therapeutic strategy for glioblastoma. Recently, a single-arm phase 2 clinical trial demonstrated a significant increase in overall survival when P-AscH- was combined with temozolomide and radiotherapy. As P-AscH- relies on iron-dependent mechanisms, this study aimed to assess the predictive potential of both molecular and imaging-based iron-related markers to enhance the personalization of P-AscH- therapy in glioblastoma participants...
February 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38269400/characterization-of-hair-metabolome-in-5xfad-mice-and-patients-with-alzheimer-s-disease-using-mass-spectrometry-based-metabolomics
#10
JOURNAL ARTICLE
Chih-Wei Chang, Jen-Yi Hsu, Yu-Tai Lo, Yu-Hsuan Liu, Onanong Mee-Inta, Hsueh-Te Lee, Yu-Min Kuo, Pao-Chi Liao
Hair emerged as a biospecimen for long-term investigation of endogenous metabolic perturbations, reflecting the chemical composition circulating in the blood over the past months. Despite its potential, the use of human hair for metabolomics in Alzheimer's disease (AD) research remains limited. Here, we performed both untargeted and targeted metabolomic approaches to profile the key metabolic pathways in the hair of 5xFAD mice, a widely used AD mouse model. Furthermore, we applied the discovered metabolites to human subjects...
January 25, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38238684/mendelian-randomization-analyses-of-known-and-suspected-risk-factors-and-biomarkers-for-myasthenia-gravis-overall-and-by-subtypes
#11
JOURNAL ARTICLE
Wenwen Wang, Wei Ge, Junling Feng, Manli Huang, Xihua Zhang, Jielai Xia, Ling Wang, Chen Li
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease that affects neuromuscular junction. The literature suggests the involvement of circulating cytokines (CK), gut microbiota (GM), and serum metabolites (SM) with MG. However, this research is limited to observational trials, and comprehensive causal relationship studies have not been conducted. Based on published datasets, this investigation employed Mendelian Randomization (MR) to analyze the known and suspected risk factors and biomarkers causal association of MG and its subtypes...
January 18, 2024: BMC Neurology
https://read.qxmd.com/read/38218027/clinical-applications-of-cerebrospinal-fluid-liquid-biopsies-in-central-nervous-system-tumors
#12
JOURNAL ARTICLE
Maria Diaz, Sofia Chudsky, Elena Pentsova, Alexandra M Miller
For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this disease...
January 12, 2024: Translational Oncology
https://read.qxmd.com/read/38160122/increased-production-of-inflammatory-cytokines-by-circulating-monocytes-in-mesial-temporal-lobe-epilepsy-a-possible-role-in-drug-resistance
#13
JOURNAL ARTICLE
C Milano, M Montali, S Barachini, I S Burzi, F Pratesi, L Petrozzi, L Chico, R Morganti, G Gambino, L Rossi, R Ceravolo, G Siciliano, P Migliorini, I Petrini, C Pizzanelli
We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant - DR, vs. drug-sensitive - DS). Patients with epilepsy showed higher levels of serum CCL2, CCL3, IL-8 and AOPP, and lower levels of FRAP and thiols compared to healthy controls (HC). Although none of the serum biomarkers distinguished DR from DS patients, when analysing intracellular cytokines after in vitro stimulation, DR patients presented higher percentages of IL-1β and IL-6 positive monocytes compared to DS patients and HC...
December 23, 2023: Journal of Neuroimmunology
https://read.qxmd.com/read/38140650/elevated-plasma-protein-carbonyl-concentration-is-associated-with-more-abnormal-white-matter-in-people-with-hiv
#14
JOURNAL ARTICLE
Patricia K Riggs, Albert M Anderson, Bin Tang, Leah H Rubin, Susan Morgello, Christina M Marra, Benjamin B Gelman, David B Clifford, Donald Franklin, Robert K Heaton, Ronald J Ellis, Christine Fennema-Notestine, Scott L Letendre
Structural brain abnormalities, including those in white matter (WM), remain common in people with HIV (PWH). Their pathogenesis is uncertain and may reflect multiple etiologies. Oxidative stress is associated with inflammation, HIV, and its comorbidities. The post-translational carbonylation of proteins results from oxidative stress, and circulating protein carbonyls may reflect this. In this cross-sectional analysis, we evaluated the associations between protein carbonyls and a panel of soluble biomarkers of neuronal injury and inflammation in plasma (N = 45) and cerebrospinal fluid (CSF, n = 32) with structural brain MRI...
December 12, 2023: Viruses
https://read.qxmd.com/read/38140053/circulating-biomarkers-for-monitoring-chemotherapy-induced-cardiotoxicity-in-children
#15
REVIEW
Luigia Meo, Maria Savarese, Carmen Munno, Peppino Mirabelli, Pia Ragno, Ornella Leone, Mariaevelina Alfieri
Most commonly diagnosed cancer pathologies in the pediatric population comprise leukemias and cancers of the nervous system. The percentage of cancer survivors increased from approximatively 50% to 80% thanks to improvements in medical treatments and the introduction of new chemotherapies. However, as a consequence, heart disease has become the main cause of death in the children due to the cardiotoxicity induced by chemotherapy treatments. The use of different cardiovascular biomarkers, complementing data obtained from electrocardiogram, echocardiography cardiac imaging, and evaluation of clinical symptoms, is considered a routine in clinical diagnosis, prognosis, risk stratification, and differential diagnosis...
November 30, 2023: Pharmaceutics
https://read.qxmd.com/read/38103252/circulating-proteomic-biomarkers-for-diagnosing-sporadic-amyotrophic-lateral-sclerosis-a-cross-sectional-study
#16
JOURNAL ARTICLE
Lu He, Qinming Zhou, Chaoyang Xiu, Yaping Shao, Dingding Shen, Huanyu Meng, Weidong Le, Sheng Chen
JOURNAL/nrgr/04.03/01300535-202408000-00039/figure1/v/2023-12-16T180322Z/r/image-tiff Biomarkers are required for the early detection, prognosis prediction, and monitoring of amyotrophic lateral sclerosis, a progressive disease. Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarkers. In this study, we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral sclerosis compared with five healthy controls...
August 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38061398/differential-profiles-of-serum-cytokines-in-parkinson-s-disease-according-to-disease-duration
#17
JOURNAL ARTICLE
Giulia Di Lazzaro, Anna Picca, Sofia Boldrini, Francesco Bove, Emanuele Marzetti, Martina Petracca, Carla Piano, Anna Rita Bentivoglio, Paolo Calabresi
OBJECTIVE: Neurodegeneration and neuroinflammation are two intertwined mechanisms contributing to the pathophysiology of Parkinson's disease. Whether circulating biomarkers reflecting those two processes differ according to disease duration remains to be established. The present study was conducted to characterize the biomarkers individuals with PD with short (≤5 years) or long disease duration (>5 years). METHODS: We consecutively enrolled 104 patients with Parkinson's disease and evaluated them using validated clinical scales (MDS-UPDRS, Hoehn and Yahr staging, MMSE)...
December 5, 2023: Neurobiology of Disease
https://read.qxmd.com/read/38049870/a-metabolomics-study-in-aqueous-humor-discloses-altered-arginine-metabolism-in-parkinson-s-disease
#18
JOURNAL ARTICLE
Joan Serrano-Marín, Silvia Marin, David Bernal-Casas, Alejandro Lillo, Marc González-Subías, Gemma Navarro, Marta Cascante, Juan Sánchez-Navés, Rafael Franco
BACKGROUND: The lack of accessible and informative biomarkers results in a delayed diagnosis of Parkinson's disease (PD), whose symptoms appear when a significant number of dopaminergic neurons have already disappeared. The retina, a historically overlooked part of the central nervous system (CNS), has gained recent attention. It has been discovered that the composition of cerebrospinal fluid influences the aqueous humor composition through microfluidic circulation. In addition, alterations found in the brain of patients with PD have a correlate in the retina...
December 4, 2023: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38045857/metabolomic-analysis-of-serum-short-chain-fatty-acid-concentrations-in-a-mouse-of-mptp-induced-parkinson-s-disease-after-dietary-supplementation-with-branched-chain-amino-acids
#19
JOURNAL ARTICLE
Na Mi, Lili Ma, Xueying Li, Jia Fu, Xinxin Bu, Fei Liu, Fan Yang, Yali Zhang, Lifen Yao
The gut microbiota and microbial metabolites influence the enteric nervous system and the central nervous system via the microbial-gut-brain axis. Increasing body of evidence suggests that disturbances in the metabolism of peripheral branched-chain amino acids (BCAAs) can contribute to the development of neurodegenerative diseases through neuroinflammatory signaling. Preliminary research has shown that longitudinal changes in serum amino acid levels in mouse models of Parkinson's disease (PD) are negatively correlated with disease progression...
2023: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38022574/immunotherapy-in-patients-with-brain-metastasis-advances-and-challenges-for-the-treatment-and-the-application-of-circulating-biomarkers
#20
REVIEW
E M Brozos-Vázquez, C Rodríguez-López, A Cortegoso-Mosquera, S López-Landrove, L Muinelo-Romay, J García-González, R López-López, L León-Mateos
The central nervous system (CNS) is one of the most frequent metastatic sites of various cancers, including lung cancer, breast cancer and melanoma. The development of brain metastases requires a specific therapeutic approach and is associated with high mortality and morbidity in cancer patients. Advances in precision medicine and the introduction in recent years of new drugs, such as immunotherapy, have made it possible to improve the prognosis of these patients by improving survival and quality of life. New diagnostic techniques such as liquid biopsy allow real-time monitoring of tumor evolution, providing molecular information on prognostic and predictive biomarkers of response to treatment in blood or other fluids...
2023: Frontiers in Immunology
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