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https://www.readbyqxmd.com/read/29730963/screening-for-intellectual-disabilities-a-validation-of-the-hayes-ability-screening-index-for-in-patients-with-substance-use-disorder
#1
Kirsten J Braatveit, Torbjørn Torsheim, Oddbjørn Hove
BACKGROUND: There is a reason to believe that many individuals with substance use disorder (SUD) in contact with services have an undiagnosed intellectual disability (ID). Assessing ID in persons with SUD can be challenging due to the influence of substances, time consumption, and specific requirements for the education of the assessor. On the other hand, an undiagnosed condition may lead to a lack of treatment adjustment and may result in drop-out from treatment or lack of treatment effect...
May 7, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29701156/diagnostic-issues-in-early-onset-obsessive-compulsive-disorder-and-their-treatment-implications
#2
Elisabetta Burchi, Stefano Pallanti
BACKGROUND: The lifespan approach and recent shift in the conceptualization of Obsessive-Compulsive Disorder (OCD) promoted by the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM5) along with novel insights into the pathogenesis of this heterogeneous disorder are driving the development of new outcome measures and new treatments for a disease that, on the other hand, is characterized by high rates of refractoriness. OBJECTIVE AND METHODS: The aim of this review is to provide a discussion of the translational evidence about Early Onset OCD (EO) in compliance with a neurodevelopmental and RdoC perspective...
April 26, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29580220/pragmatic-randomised-controlled-trial-of-a-trauma-focused-guided-self-help-programme-versus-individual-trauma-focused-cognitive-behavioural-therapy-for-post-traumatic-stress-disorder-rapid-trial-protocol
#3
Claire Nollett, Catrin Lewis, Neil Kitchiner, Neil Roberts, Katy Addison, Lucy Brookes-Howell, Sarah Cosgrove, Katherine Cullen, Anke Ehlers, Sarah Heke, Mark Kelson, Karina Lovell, Kim Madden, Kirsten McEwan, Rachel McNamara, Ceri Phillips, Timothy Pickles, Natalie Simon, Jonathan Bisson
BACKGROUND: There is good evidence that trauma-focused therapies for Post-Traumatic Stress Disorder are effective. However, they are not always feasible to deliver due a shortage of trained therapists and demands on the patient. An online trauma-focused Guided Self-Help (GSH) programme which could overcome these barriers has shown promise in a pilot study. This study will be the first to evaluate GSH against standard face-to-face therapy to assess its suitability for use in the NHS. METHODS: The study is a large-scale multi-centre pragmatic randomised controlled non-inferiority trial, with assessors masked to treatment allocation...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29557078/a-double-blind-placebo-controlled-phase-ii-study-to-determine-the-efficacy-safety-tolerability-and-pharmacokinetics-of-a-controlled-release-cr-formulation-of-mazindol-in-adults-with-dsm-5-attention-deficit-hyperactivity-disorder-adhd
#4
Tim L Wigal, Jeffrey H Newcorn, Nelson Handal, Sharon B Wigal, Ioulietta Mulligan, Virginia Schmith, Eric Konofal
BACKGROUND: Mazindol is under investigation for the treatment of attention-deficit/hyperactivity disorder (ADHD) because of its alertness-enhancing properties. A novel controlled-release (CR) formulation of mazindol was developed to allow once-daily dosing. OBJECTIVE: The aim of this study was to evaluate the efficacy of mazindol CR in adults with ADHD. DESIGN: We conducted a randomized, double-blind, placebo-controlled 6-week trial. METHODS: Subjects diagnosed with ADHD using the Mini-International Neuropsychiatric Structured Interview (MINI) and with an ADHD Rating Scale, Diagnostic and Statistical Manual of Mental Disorders 5th Edition (ADHD-RS-DSM5) score ≥ 28 were randomized to receive placebo or 1-3 mg/day of mazindol for 6 weeks...
March 2018: CNS Drugs
https://www.readbyqxmd.com/read/29478874/memory-focused-cognitive-therapy-for-cocaine-use-disorder-theory-procedures-and-preliminary-evidence-from-an-external-pilot-randomised-controlled-trial
#5
John Marsden, Camille Goetz, Tim Meynen, Luke Mitcheson, Garry Stillwell, Brian Eastwood, John Strang, Nick Grey
BACKGROUND: Cocaine use disorder (CUD) is a debilitating condition with no NICE-recommended medication or specific psychosocial interventions. In the United Kingdom (UK), general counselling (treatment-as-usual; TAU) is widely delivered, but has limited effectiveness. We tested the feasibility, safety and preliminary efficacy of a novel, adjunctive psychosocial intervention for CUD, called 'memory-focused cognitive therapy' (MFCT). METHODS: We did a two-arm, external pilot randomised controlled trial at a specialist community National Health Service addictions clinic in London, UK...
March 2018: EBioMedicine
https://www.readbyqxmd.com/read/29391802/adhd-and-lifestyle-habits-in-czech-adults-a-national-sample
#6
Simon Weissenberger, Radek Ptacek, Martina Vnukova, Jiri Raboch, Martina Klicperova-Baker, Lucie Domkarova, Michal Goetz
Background: Adult attention-deficit/hyperactivity disorder (ADHD) has been added as a diagnosis to the Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM5) in 2013, thus making ADHD, which has been classically known as a childhood disorder, a life-long disorder. Those suffering from the condition show very specific behavioral traits, which manifest as lifestyle habits; they also show comorbidities that can be the symptoms and/or consequences of certain lifestyles. Materials and methods: The targeted population was adults aged 18-65 years...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29322687/abnormal-fronto-striatal-activation-as-a-marker-of-threshold-and-subthreshold-bulimia-nervosa
#7
Marilyn Cyr, Xiao Yang, Guillermo Horga, Rachel Marsh
This study aimed to determine whether functional disturbances in fronto-striatal control circuits characterize adolescents with Bulimia Nervosa (BN) spectrum eating disorders regardless of clinical severity. FMRI was used to assess conflict-related brain activations during performance of a Simon task in two samples of adolescents with BN symptoms compared with healthy adolescents. The BN samples differed in the severity of their clinical presentation, illness duration and age. Multi-voxel pattern analyses (MVPAs) based on machine learning were used to determine whether patterns of fronto-striatal activation characterized adolescents with BN spectrum disorders regardless of clinical severity, and whether accurate classification of less symptomatic adolescents (subthreshold BN; SBN) could be achieved based on patterns of activation in adolescents who met DSM5 criteria for BN...
April 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29163237/-18f-fluorodeoxyglucose-positron-emission-tomography-in-rats-with-prolonged-cocaine-self-administration-suggests-potential-brain-biomarkers-for-addictive-behavior
#8
Nazzareno Cannella, Alejandro Cosa-Linan, Mareike Roscher, Tatiane T Takahashi, Nils Vogler, Björn Wängler, Rainer Spanagel
The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29069625/clinical-utility-of-the-dsm-5-alternative-model-for-borderline-personality-disorder-differential-diagnostic-accuracy-of-the-bfi-scid-ii-pq-and-pid-5
#9
J Christopher Fowler, Alok Madan, Jon G Allen, Michelle Patriquin, Carla Sharp, John M Oldham, B Christopher Frueh
BACKGROUND: With the publication of DSM 5 alternative model for personality disorders it is critical to assess the components of the model against evidence-based models such as the five factor model and the DSM-IV-TR categorical model. This study explored the relative clinical utility of these models in screening for borderline personality disorder (BPD). METHODS: Receiver operator characteristics and diagnostic efficiency statistics were calculated for three personality measures to ascertain the relative diagnostic efficiency of each measure...
January 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29033802/the-neurobiological-mechanism-of-chemical-aversion-emetic-therapy-for-alcohol-use-disorder-an-fmri-study
#10
Ralph L Elkins, Todd L Richards, Robert Nielsen, Richard Repass, Henriettae Stahlbrandt, Hunter G Hoffman
A recent NIH epidemiology study found the lifetime prevalence of alcohol use disorder in the United States to be 29%. Alcohol drinking behavior is strongly "learned" via pleasure center activation/reinforcement. Alcohol craving is a powerful desire to drink alcoholic beverages. Craving was added as one of the defining criteria for alcohol use disorder in DSM5, and craving reduction is becoming an increasingly important treatment goal. In the current study, patients with alcohol use disorder received 10 days of inpatient multi-modal treatments at Schick Shadel Hospital (SSH) of Seattle...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28976443/research-on-somatization-and-somatic-symptom-disorders-ars-longa-vita-brevis
#11
Joel E Dimsdale
The new Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition defines somatic symptom and related disorders as long-standing somatic symptoms that are associated with disproportionate thoughts, feelings, and behaviors, irrespective of whether or not a medical cause for these symptoms can be determined. In this Special Section of Psychosomatic Medicine, several articles address diagnostic issues and the central nervous system correlates of somatic symptom and related disorder and document new developments in its treatment...
November 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28969356/a-transdiagnostic-review-of-negative-symptom-phenomenology-and-etiology
#12
Gregory P Strauss, Alex S Cohen
In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology evaluated for schizophrenia. However, negative symptoms are not pathognomonic-they are also part of the diagnostic criteria for other schizophrenia-spectrum disorders, disorders that sometimes have comorbid psychosis, diagnoses not in the schizophrenia-spectrum, and the general "nonclinical" population. Although etiological models of negative symptoms have been developed for chronic schizophrenia, there has been little attention given to whether these models have transdiagnostic applicability...
July 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28965364/bupropion-for-attention-deficit-hyperactivity-disorder-adhd-in-adults
#13
REVIEW
Wim Verbeeck, Geertruida E Bekkering, Wim Van den Noortgate, Cornelis Kramers
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurobiological condition, characterised by behavioral and cognitive symptoms such as inattention, impulsivity and/or excessive activity. The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational and occupational underachievement.Although psychostimulant medications are the mainstay of treatment for ADHD, not all adults respond optimally to, or can tolerate, these medicines...
October 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28763736/schizophrenia-dissection-by-five-anxiety-and-depressive-subtype-comorbidities-clinical-implications-and-evolutionary-perspective
#14
André B Veras, Simone Cougo, Fernanda Meira, Clayton Peixoto, Jorge A Barros, Antonio E Nardi, Dolores Malaspina, Michael Poyurovsky, Jeffrey P Kahn
Twenty patients with DSM5 schizophrenia were comprehensively and formally assessed by an experienced psychiatrist. All subjects were assessed for: positive and negative psychotic symptoms; social anxiety; panic anxiety; obsessive compulsive disorder, atypical depression; major depression; suicide risk; and global assessment of functioning. Different profiles of clinical presentation and symptom evolution emerged for patients with schizophrenia who had co-morbid depression (15%), OCD (15%), panic or limited symptom attacks (55%) and social anxiety (5%)...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28689498/the-slow-death-of-the-concept-of-schizophrenia-and-the-painful-birth-of-the-psychosis-spectrum
#15
S Guloksuz, J van Os
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader multidimensional psychotic syndrome, yet paradoxically has become the dominant prism through which everything 'psychotic' is observed, even affective states with mild psychosis labelled 'ultra-high risk' (for schizophrenia). The inability of psychiatry to frame psychosis as multidimensional syndromal variation of largely unpredictable course and outcome - within and between individuals - hampers research and recovery-oriented practice...
January 2018: Psychological Medicine
https://www.readbyqxmd.com/read/28604808/a-korean-validation-study-of-the-clinically-useful-anxiety-outcome-scale-comorbidity-and-differentiation-of-anxiety-and-depressive-disorders
#16
Sang Won Jeon, Changsu Han, Young-Hoon Ko, Seoyoung Yoon, Chi-Un Pae, Joonho Choi, Jae-Min Kim, Ho-Kyoung Yoon, Hoseon Lee, Ashwin A Patkar, Mark Zimmerman
BACKGROUND: This study aimed to evaluate the psychometric properties of the Korean version of the Clinically Useful Anxiety Outcome Scale (CUXOS) and to examine the current diagnostic comorbidity and differential severity of anxiety symptoms between major depressive disorder (MDD) and anxiety disorders. METHODOLOGY: In total, 838 psychiatric outpatients were analyzed at their intake appointment. Diagnostic characteristics were examined using the structured clinical interview from the DSM-IV because the DSM5 was not available at the start of the study...
2017: PloS One
https://www.readbyqxmd.com/read/28527713/stability-or-instability-in-avoidant-personality-disorder-mode-fluctuations-within-schema-therapy-sessions
#17
Ofer Peled, Eran Bar-Kalifa, Eshkol Rafaeli
BACKGROUND AND OBJECTIVES: Avoidant personality disorder (APD) is among the most prevalent personality disorders, but has received relatively little empirical attention. This study aims to characterize the frequency, intensity, and fluctuation patterns seen in the modes (self-states) of APD clients over the course of schema therapy (ST), a psychotherapy approach developed especially for personality disorders. METHOD: The newly-developed client mode rating scale (CMRS) was used to code every 5-min segment (n = 645) of 60 ST sessions...
May 6, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28254549/assessing-the-factorial-structure-and-measurement-invariance-of-ptsd-by-gender-and-ethnic-groups-in-sri-lanka-an-analysis-of-the-modified-harvard-trauma-questionnaire-htq
#18
Alvin Kuowei Tay, Rohan Jayasuriya, Dinuk Jayasuriya, Derrick Silove
The Harvard Trauma Questionnaire (HTQ) remains the most widely used screening measure for post-traumatic stress disorder (PTSD) in the refugee and post-conflict field. The present study is the first to test the factorial structure and measurement invariance of the HTQ according to DSM-5 criteria across gender and ethnic groups in the ethnically diverse society of post-conflict Sri Lanka. The survey sample included 5136 participants (86% response rate) followed up 12 months after a baseline nationally representative survey undertaken in Sri Lanka in 2014...
April 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#19
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28124571/the-dsm5-rdoc-debate-on-the-future-of-mental-health-research-implication-for-studies-on-human-stress-and-presentation-of-the-signature-bank
#20
S J Lupien, M Sasseville, N François, C E Giguère, J Boissonneault, P Plusquellec, R Godbout, L Xiong, S Potvin, E Kouassi, A Lesage
In 2008, the National Institute of Mental Health (NIMH) announced that in the next few decades, it will be essential to study the various biological, psychological and social "signatures" of mental disorders. Along with this new "signature" approach to mental health disorders, modifications of DSM were introduced. One major modification consisted of incorporating a dimensional approach to mental disorders, which involved analyzing, using a transnosological approach, various factors that are commonly observed across different types of mental disorders...
January 2017: Stress: the International Journal on the Biology of Stress
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