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https://www.readbyqxmd.com/read/29334535/simultaneous-presentation-of-wilms-tumor-and-contralateral-ganglioneuroma-in-a-child-case-report-and-literature-review
#1
Zuhal Bayramoglu, Ibrahim Adaletli, Emine Caliskan, Isin Kilicaslan, Cagla S Karaoglan, Alaattin Celik, Feryal Gun Soysal, Sema B Bay, Bulent Zulfikar
We demonstrate a 4-year-old girl who presented with progressive, asymmetrical, firm abdominal distention and was diagnosed with synchronous Wilms' tumor and left para-aortic ganglioneuroma (GN). Although synchronous tumors in the pediatric population are commonly associated with malignancy-predisposing syndromes, the patient in question was found to be otherwise healthy and had no clinical evidence nor family history of a syndrome. This case is the second one in the literature diagnosed with synchronous presentation of Wilms' tumor and GN in a previously healthy child...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29333421/brain-metastasis-from-colorectal-cancer-a-single-center-experience
#2
Dong-Yeop Kim, Chun-Geun Ryu, Eun-Joo Jung, Jin-Hee Paik, Dae-Yong Hwang
Purpose: The detection rate of brain metastasis (BM) from colorectal cancer (CRC) is increasing. This study was designed to analyze the clinical features of BM and prognosis according to the therapeutic modalities. Methods: A total of 19 cases were collected in this study between November 2008 and December 2015. We reviewed the patients' demographic data and the clinical features of BM retrospectively and investigated their prognostic significance. Results: Nineteen patients included 8 male and 11 female patients...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29333113/grating-oriented-line-wise-filtration-golf-for-dual-energy-x-ray-ct
#3
Yan Xi, Wenxiang Cong, Daniel Harrison, Ge Wang
In medical X-ray Computed Tomography (CT), the use of two distinct X-ray source spectra (energies) allows dose-reduction and material discrimination relative to that achieved with only one source spectrum. Existing dual-energy CT methods include source kVp-switching, double-layer detection, dual-source gantry, and two-pass scanning. Each method suffers either from strong spectral correlation or patient-motion artifacts. To simultaneously address these problems, we propose to improve CT data acquisition with the Grating Oriented Line-wise Filtration (GOLF) method, a novel X-ray filter that is placed between the source and patient...
December 2017: Sensing and Imaging
https://www.readbyqxmd.com/read/29332829/synchronous-detection-of-ebolavirus-conserved-rna-sequences-and-ebolavirus-encoded-mirna-like-fragment-based-on-a-zwitterionic-copper-ii-metal-organic-framework
#4
Gui-Hua Qiu, Zi-Hua Weng, Pei-Pei Hu, Wen-Jun Duan, Bao-Ping Xie, Bin Sun, Xiao-Yan Tang, Jin-Xiang Chen
From a three-dimensional (3D) metal-organic framework (MOF) of {[Cu(Cmdcp)(phen)(H2O)]2·9H2O}n (1, H3CmdcpBr = N-carboxymethyl-(3,5-dicarboxyl)pyridinium bromide, phen = phenanthroline), a sensitive and selective fluorescence sensor has been developed for the simultaneous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded microRNA-like (miRNA-like) fragment. The results from molecular dynamics simulation confirmed that MOF 1 absorbs carboxyfluorescein (FAM)-tagged and 5(6)-carboxyrhodamine, triethylammonium salt (ROX)-tagged probe ss-DNA (probe DNA, P-DNA) by π…π stacking and hydrogen bonding, as well as additional electrostatic interactions to form a sensing platform of P-DNAs@1 with quenched FAM and ROX fluorescence...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332357/management-of-b3-lesions-of-the-breast-implementations-of-current-recommendations-in-clinical-practice
#5
Konstantinos Stergios, Ashraf Patel, Vasilios Pergialiotis
PURPOSE: Stereotactic needle breast biopsy and vacuum assisted breast biopsy have replaced wide local excision in the last decades. B3 lesions of the breast represent a particular subgroup which is difficult to manage. The purpose of the present study was to present our experience with this specific type of lesions and to examine the conformity of Princess Margaret Hospital with current recommendations. METHODS: We retrospectively searched for patients that attended the Breast Clinic of Princess Alexandra Hospital during the period 2012-2015, and were diagnosed with B3 lesions during stereotactic needle core biopsy...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332296/plant-cell-cultures-as-model-systems-to-study-programmed-cell-death
#6
Sara Cimini, Maria Beatrice Ronci, Elisabetta Barizza, Maria Concetta de Pinto, Vittoria Locato, Fiorella Lo Schiavo, Laura De Gara
The study of programmed cell death (PCD) activated in a certain group of cells is complex when analyzed in the whole plant. Plant cell suspension cultures are useful when investigating PCD triggered by environmental and developmental stimuli. Due to their homogeneity and the possibility to synchronize their responses induced by external stimuli, these cultures are used for studying the signaling pathways leading to PCD. The first problem in the analysis of PCD in cell cultures is the quantification of cell viability/death over time...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29331829/additional-small-dose-of-prostaglandin-f2%C3%AE-at-timed-artificial-insemination-failed-to-improve-pregnancy-risk-of-lactating-dairy-cows
#7
J A Sauls, B E Voelz, L G D Mendonça, J S Stevenson
Two experiments were performed to test the hypothesis that administering PGF2α concurrent with timed artificial insemination (AI) in lactating dairy cows would enhance pregnancy per AI (P/AI). In experiment 1, lactating Holstein cows (n = 289) in one herd were enrolled after a non-pregnancy diagnosis (30-36 d after AI) to synchronize subsequent ovulation before AI. Cows were assigned randomly to receive (im) 10 mg of PGF2α concurrent with timed AI (Day 0; treatment) or no injection (control). Blood samples were collected on Days -3, 0, and 13 to determine serum concentrations of progesterone...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29331582/inositol-polyphosphates-contribute-to-cellular-circadian-rhythms-implications-for-understanding-lithium-s-molecular-mechanism
#8
Heather Wei, Dominic Landgraf, George Wang, Michael J McCarthy
Most living organisms maintain cell autonomous circadian clocks that synchronize critical biological functions with daily environmental cycles. In mammals, the circadian clock is regulated by inputs from signaling pathways including glycogen synthase kinase 3 (GSK3). The drug lithium has actions on GSK3, and also on inositol metabolism. While it is suspected that lithium's inhibition of GSK3 causes rhythm changes, it is not known if inositol polyphosphates can also affect the circadian clock. We examined whether the signaling molecule inositol hexaphosphate (IP6) has effects on circadian rhythms...
January 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29331431/robust-synchronization-of-master-slave-chaotic-systems-using-approximate-model-an-experimental-study
#9
Hafiz Ahmed, Ivan Salgado, Héctor Ríos
Robust synchronization of master slave chaotic systems are considered in this work. First an approximate model of the error system is obtained using the ultra-local model concept. Then a Continuous Singular Terminal Sliding-Mode (CSTSM) Controller is designed for the purpose of synchronization. The proposed approach is output feedback-based and uses fixed-time higher order sliding-mode (HOSM) differentiator for state estimation. Numerical simulation and experimental results are given to show the effectiveness of the proposed technique...
January 10, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29330588/whole-body-3d-kinematics-of-bird-take-off-key-role-of-the-legs-to-propel-the-trunk
#10
Pauline Provini, Anick Abourachid
Previous studies showed that birds primarily use their hindlimbs to propel themselves into the air in order to take-off. Yet, it remains unclear how the different parts of their musculoskeletal system move to produce the necessary acceleration. To quantify the relative motions of the bones during the terrestrial phase of take-off, we used biplanar fluoroscopy in two species of birds, diamond dove (Geopelia cuneata) and zebra finch (Taeniopygia guttata). We obtained a detailed 3D kinematics analysis of the head, the trunk and the three long bones of the left leg...
January 6, 2018: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29330551/autapses-promote-synchronization-in-neuronal-networks
#11
Huawei Fan, Yafeng Wang, Hengtong Wang, Ying-Cheng Lai, Xingang Wang
Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outstanding problem. We offer an alternative principle to assess the physiological role of neuronal synchrony based on identifying structural anomalies in the underlying network and studying their impacts on the collective dynamics...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330131/response-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-to-several-pharmacological-agents-when-intrinsic-syncytial-pacing-is-overcome-by-acute-external-stimulation
#12
Haoyu Zeng, Bharathi Balasubramanian, Armando Lagrutta, Frederick Sannajust
We challenged human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) syncytia, mainly, CDI iCells with several classes of well-characterized pharmacological agents (including hERG blocker, Nav1.5 blocker, Cav1.2 blocker and opener, β-adrenergic agonist, and If blocker) under pacing conditions, utilizing the Cardio-ECR instrument, a non-invasive platform featuring simultaneous and continuous measurement of synchronized beating rate and contractility (both signals were acquired simultaneously and well aligned) ...
January 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29330074/a-nonlinear-continuous-time-model-for-a-semelparous-species
#13
A Veprauskas
Periodical semelparous insects such as cicadas and May beetles exhibit synchronization in age classes such that only one age class is present at any point of time. This leads to outbreaks of adults as they all reach maturity around the same time. Discrete-time models of semelparous species have shown that this type of synchronous cycling can occur as a result of greater between-class competition relative to within-class competition. However, relatively few studies have examined continuous-time models of semelparous species...
January 9, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29330009/the-almanach-project-preliminary-results-and-potentiality-from-afghanistan
#14
A Bernasconi, F Crabbé, R Rossi, I Qani, A Vanobberghen, M Raab, S Du Mortier
INTRODUCTION: ALMANACH (ALgorithms for the MANagement of Acute CHildhood illnesses) is an electronic version of IMCI (Integrated Management of Childhood Illness) running on tablets. ALMANACH enhances its concept, it integrates well into health staff's daily consultation work and facilitates diagnosis and treatment. ALMANACH informs when to refer a child or to perform a rapid diagnostic test (RDT), recommends the right treatment dosage and synchronizes collected data real time with a Health Management Information System (DHIS2) for epidemiological evaluation and decision making...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29329997/clinical-log-data-analysis-for-assessing-the-accuracy-of-the-cyberknife-fiducial-free-lung-tumor-tracking-system
#15
Masao Nakayama, Hideki Nishimura, Hiroshi Mayahara, Masaki Nakamura, Kazuyuki Uehara, Shinji Tsudou, Aya Harada, Hiroaki Akasaka, Ryohei Sasaki
PURPOSE: The CyberKnife Xsight Lung Tracking (XLT) and 1-View tracking systems can synchronize beam targeting to a visible lung tumor with respiratory motion during irradiation without requiring internal fiducial markers. The systems use a correlation model that relates external marker positions to tumor positions as well as a prediction model that predicts the target's future position. In this study, the correlation and prediction model uncertainties related to the CyberKnife fiducial-free tumor tracking system were evaluated using clinical log data...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29329933/combined-hepatic-and-pulmonary-metastasectomies-from-colorectal-carcinoma-data-from-the-prospective-spanish-registry-2008-2010
#16
Jose R Jarabo, Ana M Gómez, Joaquín Calatayud, Carlos A Fraile, Elena Fernández, Nuria Pajuelo, Raul Embún, Laureano Molins, Juan J Rivas, Florentino Hernando
INTRODUCTION: Resection of both liver and lung metastases from colorectal carcinoma (CRC) is a standard of care in selected patients with oligometastatic disease. We present here the analysis of the subgroup of patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases (PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR). METHODS: We analyze characteristics, survival and prognostic factors of patients undergoing combined resection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospective multicenter Spanish Registry...
January 9, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29329157/smad4-loss-correlates-with-higher-rates-of-local-and-distant-failure-in-pancreatic-adenocarcinoma-patients-receiving-adjuvant-chemoradiation
#17
Joseph M Herman, Salma K Jabbour, Steven H Lin, Matthew P Deek, Charles C Hsu, Elliot K Fishman, Sinae Kim, John L Cameron, Marina Chekmareva, Daniel A Laheru, Amol K Narang, Timothy M Pawlik, Ralph H Hruban, Christopher L Wolfgang, Christine A Iacobuzio-Donahue
OBJECTIVES: The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDAs). We examined whether Smad4 tumor status was associated with outcomes after adjuvant chemoradiation (CRT) for resected PDAs. METHODS: Patients treated with adjuvant CRT were identified (N = 145). Smad4 status was determined by immunolabeling and graded as intact or lost. Kaplan-Meier method and multivariable competing risk analyses were performed...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29328954/probing-the-stereoselective-interaction-of-ofloxacin-enantiomers-with-corresponding-monoclonal-antibodies-by-multiple-spectrometry
#18
Hongtao Mu, Zhenlin Xu, Yingju Liu, Yuanming Sun, Baoling Wang, Xiulan Sun, Zhanhui Wang, Sergei Eremin, Anatoly V Zherdev, Boris B Dzantiev, Hongtao Lei
Although stereoselective antibody has immense potential in chiral compounds detection and separation, the interaction traits between stereoselective antibody and the corresponding antigenic enantiomers are not yet fully exploited. In this study, the stereospecific interactions between ofloxacin isomers and corresponding monoclonal antibodies (McAb-WR1 and McAb-MS1) were investigated using time-resolved fluorescence, steady-state fluorescence, and circular dichroism (CD) spectroscopic methods. The chiral recognition discrepancies of antibodies with ofloxacin isomers were reflected through binding constant, number of binding sites, driving forces and conformational changes...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29328736/dynamical-formation-of-kerr-black-holes-with-synchronized-hair-an-analytic-model
#19
Carlos A R Herdeiro, Eugen Radu
East and Pretorius have successfully evolved, using fully nonlinear numerical simulations, the superradiant instability of the Kerr black hole (BH) triggered by a massive, complex vector field. Evolutions terminate in stationary states of a vector field condensate synchronized with a rotating BH horizon. We show that these end points are fundamental states of Kerr BHs with synchronized Proca hair. Motivated by the "experimental data" from these simulations, we suggest a universal (i.e., field-spin independent), analytic model for the subset of BHs with synchronized hair that possess a quasi-Kerr horizon, applicable in the weak hair regime...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328734/connecting-the-kuramoto-model-and-the-chimera-state
#20
Tejas Kotwal, Xin Jiang, Daniel M Abrams
Since its discovery in 2002, the chimera state has frequently been described as a counterintuitive, puzzling phenomenon. The Kuramoto model, in contrast, has become a celebrated paradigm useful for understanding a range of phenomena related to phase transitions, synchronization, and network effects. Here we show that the chimera state can be understood as emerging naturally through a symmetry-breaking bifurcation from the Kuramoto model's partially synchronized state. Our analysis sheds light on recent observations of chimera states in laser arrays, chemical oscillators, and mechanical pendula...
December 29, 2017: Physical Review Letters
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