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https://www.readbyqxmd.com/read/28334851/the-modulatory-effect-of-adaptive-deep-brain-stimulation-on-beta-bursts-in-parkinson-s-disease
#1
Gerd Tinkhauser, Alek Pogosyan, Simon Little, Martijn Beudel, Damian M Herz, Huiling Tan, Peter Brown
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches...
February 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334315/ecological-factors-affecting-the-flight-phenology-of-the-endangered-coenonympha-nipisiquit-lepidoptera-nymphalidae
#2
Billie Chiasson, Gaétan Moreau
Coenonympha nipisiquit McDunnough (Lepidoptera: Nymphalidae) is an endemic butterfly species that has been recorded only in 10 salt marshes of eastern Canada. Despite obtaining the endangered status and benefiting from a conservation program, the populations of this species appear to be declining. However, a lack of information about the ecology of the species and current demographics undermines potential in-situ conservation efforts. To identify the environmental factors affecting the emergence phenology and flight period of this species, daily visual counts of adult C...
March 17, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28334225/pom-thalamocortical-input-drives-layer-specific-microcircuits-in-somatosensory-cortex
#3
Nicholas J Audette, Joanna Urban-Ciecko, Megumi Matsushita, Alison L Barth
Higher-order thalamic nuclei, such as the posterior medial nucleus (POm) in the somatosensory system or the pulvinar in the visual system, densely innervate the cortex and can influence perception and plasticity. To systematically evaluate how higher-order thalamic nuclei can drive cortical circuits, we investigated cell-type selective responses to POm stimulation in mouse primary somatosensory (barrel) cortex, using genetically targeted whole-cell recordings in acute brain slices. We find that ChR2-evoked thalamic input selectively targets specific cell types in the neocortex, revealing layer-specific modules for the summation and processing of POm input...
March 10, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334187/individual-differences-in-human-auditory-processing-insights-from-single-trial-auditory-midbrain-activity-in-an-animal-model
#4
Travis White-Schwoch, Trent Nicol, Catherine M Warrier, Daniel A Abrams, Nina Kraus
Auditory-evoked potentials are classically defined as the summations of synchronous firing along the auditory neuraxis. Converging evidence supports a model whereby timing jitter in neural coding compromises listening and causes variable scalp-recorded potentials. Yet the intrinsic noise of human scalp recordings precludes a full understanding of the biological origins of individual differences in listening skills. To delineate the mechanisms contributing to these phenomena, in vivo extracellular activity was recorded from inferior colliculus in guinea pigs to speech in quiet and noise...
October 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28334175/attenuated-fast-steady-state-visual-evoked-potentials-during-human-sleep
#5
Omer Sharon, Yuval Nir
During sleep, external sensory events rarely elicit a behavioral response or affect perception. However, how sensory processing differs between wakefulness and sleep remains unclear. A major difficulty in this field stems from using brief auditory stimuli that often trigger nonspecific high-amplitude "K-complex" responses and complicate interpretation. To overcome this challenge, here we delivered periodic visual flicker stimulation across sleep and wakefulness while recording high-density electroencephalography (EEG) in humans...
February 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334126/heartfelt-self-cardio-visual-integration-affects-self-face-recognition-and-interoceptive-cortical-processing
#6
Alejandra Sel, Ruben T Azevedo, Manos Tsakiris
The sense of body-ownership relies on the representation of both interoceptive and exteroceptive signals coming from one's body. However, it remains unknown how the integration of bodily signals coming from "outside" and "inside" the body is instantiated in the brain. Here, we used a modified version of the Enfacement Illusion to investigate whether the integration of visual and cardiac information can alter self-face recognition (Experiment 1) and neural responses to heartbeats (Experiment 2). We projected a pulsing shade, that was synchronous or asynchronous with the participant's heartbeat, onto a picture depicting the participant's face morphed with the face of an unfamiliar other...
October 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28334016/does-shoe-heel-design-influence-ground-reaction-forces-and-knee-moments-during-maximum-lunges-in-elite-and-intermediate-badminton-players
#7
Wing-Kai Lam, Jaejin Ryue, Ki-Kwang Lee, Sang-Kyoon Park, Jason Tak-Man Cheung, Jiseon Ryu
BACKGROUND: Lunge is one frequently executed movement in badminton and involves a unique sagittal footstrike angle of more than 40 degrees at initial ground contact compared with other manoeuvres. This study examined if the shoe heel curvature design of a badminton shoe would influence shoe-ground kinematics, ground reaction forces, and knee moments during lunge. METHODS: Eleven elite and fifteen intermediate players performed five left-forward maximum lunge trials with Rounded Heel Shoe (RHS), Flattened Heel Shoe (FHS), and Standard Heel Shoes (SHS)...
2017: PloS One
https://www.readbyqxmd.com/read/28333685/a-spatially-resolved-network-spike-in-model-neuronal-cultures-reveals-nucleation-centers-circular-traveling-waves-and-drifting-spiral-waves
#8
A V Paraskevov, D K Zendrikov
We show that in model neuronal cultures, where the probability of interneuronal connection formation decreases exponentially with increasing distance between the neurons, there exists a small number of spatial nucleation centers of a network spike, from where the synchronous spiking activity starts propagating in the network typically in the form of circular traveling waves. The number of nucleation centers and their spatial locations are unique and unchanged for a given realization of neuronal network but are different for different networks...
March 23, 2017: Physical Biology
https://www.readbyqxmd.com/read/28332561/inertial-bioluminescence-rhythms-at-the-capo-passero-km3net-italia-site-central-mediterranean-sea
#9
J Aguzzi, E Fanelli, T Ciuffardi, A Schirone, J Craig
In the deep sea, the sense of time is dependent on geophysical fluctuations, such as internal tides and atmospheric-related inertial currents, rather than day-night rhythms. Deep-sea neutrino telescopes instrumented with light detecting Photo-Multiplier Tubes (PMT) can be used to describe the synchronization of bioluminescent activity of abyssopelagic organisms with hydrodynamic cycles. PMT readings at 8 different depths (from 3069 to 3349 m) of the NEMO Phase 2 prototype, deployed offshore Capo Passero (Sicily) at the KM3NeT-Italia site, were used to characterize rhythmic bioluminescence patterns in June 2013, in response to water mass movements...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332018/seasonal-loss-and-resumption-of-circadian-rhythms-in-hibernating-arctic-ground-squirrels
#10
Cory T Williams, Maya Radonich, Brian M Barnes, C Loren Buck
Circadian clocks are near universal among organisms and play a key role in coordinating physiological and metabolic functions to anticipate or coincide with predictable daily changes in the physical and social environment. However, whether circadian rhythms persist and are functionally important during hibernation in all mammals is currently unclear. We examined whether circadian rhythms of body temperature (T b) persist during multi-day, steady-state torpor and investigated the association between timing of animal emergence, exposure to light, and resumption of activity and T b rhythms in free-living and captive male arctic ground squirrels...
March 22, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28331994/daily-socs1-rhythms-alter-with-aging-differentially-in-peripheral-clocks-in-male-wistar-rats-therapeutic-effects-of-melatonin
#11
Ch Vinod, Anita Jagota
Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats...
March 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28331632/group-housed-females-promote-production-of-asexual-ootheca-in-american-cockroaches
#12
Ko Katoh, Masazumi Iwasaki, Shouhei Hosono, Atsushi Yoritsune, Masanori Ochiai, Makoto Mizunami, Hiroshi Nishino
BACKGROUND: Facultative parthenogenesis, seen in many animal phyla, is a reproductive strategy in which females are able to generate offspring when mating partners are unavailable. In some subsocial and eusocial insects, parthenogenesis is often more prevalent than sexual reproduction. However, little is known about how social cooperation is linked to the promotion of parthenogenesis. The domiciliary cockroach Periplaneta americana is well-suited to addressing this issue as this species belongs to the superfamily Blattoidea, which diverged into eusocial termites and shows facultative parthenogenesis...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28331201/synchrony-of-plant-cellular-circadian-clocks-with-heterogeneous-properties-under-light-dark-cycles
#13
Masaaki Okada, Tomoaki Muranaka, Shogo Ito, Tokitaka Oyama
Individual cells in a plant can work independently as circadian clocks, and their properties are the basis of various circadian phenomena. The behaviour of individual cellular clocks in Lemna gibba was orderly under 24-h light/dark cycles despite their heterogeneous free-running periods (FRPs). Here, we reveal the entrainment habits of heterogeneous cellular clocks using non-24-h light/dark cycles (T-cycles). The cellular rhythms of AtCCA1::LUC under T = 16 h cycles showed heterogeneous entrainment that was associated with their heterogeneous FRPs...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330987/architecture-and-mechanism-of-the-central-gear-in-an-ancient-molecular-timer
#14
REVIEW
Martin Egli
Molecular clocks are the product of natural selection in organisms from bacteria to human and their appearance early in evolution such as in the prokaryotic cyanobacterium Synechococcus elongatus suggests that these timers served a crucial role in genetic fitness. Thus, a clock allows cyanobacteria relying on photosynthesis and nitrogen fixation to temporally space the two processes and avoid exposure of nitrogenase carrying out fixation to high levels of oxygen produced during photosynthesis. Fascinating properties of molecular clocks are the long time constant, their precision and temperature compensation...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28330464/spectral-temporal-eeg-dynamics-of-speech-discrimination-processing-in-infants-during-sleep
#15
Phillip M Gilley, Kristin Uhler, Kaylee Watson, Christine Yoshinaga-Itano
BACKGROUND: Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Previous research has established that such paradigms, such as the mismatch response or mismatch negativity, are useful for examining auditory processes in young children and infants across various sleep and attention states. The extent to which oddball ERP responses may reflect subtle discrimination effects, such as speech discrimination, is largely unknown, especially in infants that have not yet acquired speech and language...
March 22, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28330095/potential-mosquito-repellent-compounds-of-ocimum-species-against-3n7h-and-3q8i-of-anopheles-gambiae
#16
Venugopal Gaddaguti, Talluri Venkateswara Rao, Allu Prasada Rao
Mosquitoes are exceptionally efficient in detecting their hosts for blood meal using odorant binding proteins, viz. 3N7H and 3Q8I and spread several dreadful diseases. DEET is a synthetic mosquito repellent widely used all over world for protection against mosquito bite. Reports reveal that, synthetic mosquito repellents may pose health problems in considerably large population. In view of the above fact, we made an attempt to discover efficient and novel natural mosquito repellent compounds with least impact on human health...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328859/single-stage-nonintubated-uniportal-thoracoscopic-resection-of-synchronous-bilateral-pulmonary-nodules-after-coil-labeling-a-case-report-and-literature-review
#17
Miao Zhang, Tao Wang, You-Wei Zhang, Wen-Bin Wu, Heng Wang, Rong-Hua Xu
RATIONALE: Preoperative localization of small pulmonary nodules is essential for precise resection, besides, the optimal treatment for pulmonary nodules is controversial and the prognosis without surgery is uncertain. PATIENT CONCERNS: Herein we present a patient with compromised pulmonary function harboring synchronous triple ground-glass nodules located separately in different pulmonary lobes. DIAGNOSES: The pathological diagnosis of the nodules were chronic inflammation, inflammatory pseudotumor and atypical adenomatous hyperplasia, respectively...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327965/carbon-dating-cancer-defining-the-chronology-of-metastatic-progression-in-colorectal-cancer
#18
H Lote, I Spiteri, L Ermini, A Vatsiou, A Roy, A McDonald, N Maka, M Balsitis, N Bose, M Simbolo, A Mafficini, A Lampis, J C Hahne, F Trevisani, Z Eltahir, G Mentrasti, C Findlay, Eaj Kalkman, M Punta, B Werner, S Lise, A Aktipis, C Maley, M Greaves, C Braconi, J White, M Fassan, A Scarpa, A Sottoriva, N Valeri
Background: HASH(0x567fdd8) Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but lack of chronological references makes dating the exact onset of tumours very challenging. Patients and Methods: HASH(0x47d6dc8) Here we describe the case of a colorectal cancer patient presenting with synchronous lung metastasis and metachronous thyroid, chest wall and urinary tract metastases over the course of five years...
February 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327291/solid-pseudopapillary-neoplasm-of-the-pancreas-a-clinicopathological-review-of-20-cases-including-rare-examples
#19
Ayca Ersen, Anil Aysal Agalar, Erdener Ozer, Cihan Agalar, Tarkan Unek, Tufan Egeli, Mucahit Ozbilgin, Ibrahim Astarcioglu, Mustafa Olguner, Funda Obuz, Ozgul Sagol
AIMS: Solid-pseudopapillary neoplasm (SPN) is an uncommon malignant tumor of the pancreas with a favorable prognosis unlike other pancreatic neoplasms. We investigated the clinicopathological features of 20 patients with SPN in details. METHODS: The patients diagnosed as SPN in Dokuz Eylul University Hospital between January 2005 and March 2016 were reviewed in terms of clinical and histopathological data. RESULTS: Mean age of the patients was 33...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28326957/alk-gene-copy-number-gain-and-immunohistochemical-expression-status-using-three-antibodies-in-neuroblastoma
#20
Eun Kyung Kim, Sewha Kim
Anaplastic lymphoma kinase ( ALK) gene aberrations-such as mutations, amplifications, and copy number gains-represent a major genetic predisposition to neuroblastoma (NB). This study aimed to evaluate the correlation between ALK gene copy number status, ALK protein expression, and clinicopathological parameters. We retrospectively retrieved 30 cases of poorly differentiated NB and constructed tissue microarrays (TMAs). ALK copy number changes were assessed by fluorescence in situ hybridization (FISH) assays, and ALK immunohistochemistry (IHC) testing was performed using three different antibodies (ALK1, D5F3, and 5A4 clones)...
March 2017: Pediatric and Developmental Pathology
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