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https://www.readbyqxmd.com/read/28724645/effect-of-maternal-high-dosages-of-folic-acid-supplements-on-neurocognitive-development-in-children-at-4-5-years-of-age-the-prospective-birth-cohort-infancia-y-medio-ambiente-inma-study
#1
Desirée Valera-Gran, Eva M Navarrete-Muñoz, Manuela Garcia de la Hera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea, Nekane Balluerka, Mario Murcia, Llúcia González-Safont, Dora Romaguera, Jordi Julvez, Jesús Vioque
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 μg/d) on child neurocognitive outcomes.Objective: The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y...
July 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28712138/hematologic-reference-intervals-and-age-effect-in-european-strigiformes
#2
Susana Agusti Montolio, Rafael Molina López, Carolyn Cray, Santiago Lavín González, Olga Nicolás Francisco, Ignasi Marco Sánchez, Encarna Casas-Díaz, Rafaela Cuenca Valera
BACKGROUND: The clinical importance of hematologic testing in avian veterinary medicine is reflected in the increasing number of studies for the establishment of hematologic RIs of Strigiformes and other species. Age is an important physiologic factor in birds and the effect on hematology variable should be understood. OBJECTIVES: The objective of this study was to determine baseline data of hematologic variables in 5 species of Iberian Strigiformes in different age classes...
July 16, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28705871/reply-to-csifcs%C3%A3-k-and-mittner-fitting-data-to-neural-models-of-mind-wandering
#3
Aaron Kucyi, Michael Esterman, Eve M Valera
No abstract text is available yet for this article.
July 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28698375/bmtp-11-is-active-in-preclinical-models-of-human-osteosarcoma-and-a-candidate-targeted-drug-for-clinical-translation
#4
Valerae O Lewis, Eswaran Devarajan, Marina Cardó-Vila, Dafydd G Thomas, Eugenie S Kleinerman, Serena Marchiò, Richard L Sidman, Renata Pasqualini, Wadih Arap
Osteosarcoma occurs predominantly in children and young adults. High-grade tumors require multidisciplinary treatment consisting of chemotherapy in the neoadjuvant and adjuvant settings, along with surgical intervention. Despite this approach, death from respiratory failure secondary to the development and progression of pulmonary metastases remains a significant problem. Here, we identify the IL-11 receptor α subunit (IL-11Rα) as a cell surface marker of tumor progression that correlates with poor prognosis in patients with osteosarcoma...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28694725/impact-of-reference-change-value-rcv-based-autoverification-on-turnaround-time-and-physician-satisfaction
#5
Esther Fernández-Grande, Carolina Valera-Rodriguez, Luis Sáenz-Mateos, Amparo Sastre-Gómez, Pilar García-Chico, Teodoro J Palomino-Muñoz
BACKGROUND: For a quicker delivery of laboratory test results to the hospital emergency department (ED), we implemented an autoverification system based on the reference change value (RCV). The aim of this study was to assess how the RCV based autoverification reflected on turnaround time (TAT) and on physician satisfaction. MATERIALS AND METHODS: The laboratory information system (LIS) was programmed to autoverify the results as long as they were within the range settled by RCV, so that the autoverified results were reported to the physician as soon as the tests were carried out, without any further intervention...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28688631/are-early-physical-activity-and-sedentary-behaviors-related-to-working-memory-at-7-and-14-years-of-age
#6
Mónica López-Vicente, Judith Garcia-Aymerich, Jaume Torrent-Pallicer, Joan Forns, Jesús Ibarluzea, Nerea Lertxundi, Llúcia González, Desirée Valera-Gran, Maties Torrent, Payam Dadvand, Martine Vrijheid, Jordi Sunyer
OBJECTIVE: To evaluate the role of extracurricular physical activity and sedentary behavior at preschool and primary school age on working memory at primary school age and adolescence, respectively. STUDY DESIGN: This prospective study was based on a birth cohort across 4 Spanish regions. In the 3 younger subcohorts (n = 1093), parents reported lifestyle habits of child at age 4 years of age on a questionnaire, and children performed a computerized working memory task at 7 years of age...
June 27, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28686186/development-of-a-new-microextraction-fiber-combined-to-on-line-sample-stacking-capillary-electrophoresis-uv-detection-for-acidic-drugs-determination-in-real-water-samples
#7
Maria Espina-Benitez, Lilia Araujo, Avismelsi Prieto, Alberto Navalón, José Luis Vílchez, Paola Valera, Ana Zambrano, Vincent Dugas
A new analytical method coupling a (off-line) solid-phase microextraction with an on-line capillary electrophoresis (CE) sample enrichment technique was developed for the analysis of ketoprofen, naproxen and clofibric acid from water samples, which are known as contaminants of emerging concern in aquatic environments. New solid-phase microextraction fibers based on physical coupling of chromatographic supports onto epoxy glue coated needle were studied for the off-line preconcentration of these micropollutants...
July 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28680419/novel-synechococcus-genomes-reconstructed-from-freshwater-reservoirs
#8
Pedro J Cabello-Yeves, Jose M Haro-Moreno, Ana-Belen Martin-Cuadrado, Rohit Ghai, Antonio Picazo, Antonio Camacho, Francisco Rodriguez-Valera
Freshwater picocyanobacteria including Synechococcus remain poorly studied at the genomic level, compared to their marine representatives. Here, using a metagenomic assembly approach we discovered two novel Synechococcus sp. genomes from two freshwater reservoirs Tous and Lake Lanier, both sharing 96% average nucleotide identity and displaying high abundance levels in these two lakes located at similar altitudes and temperate latitudes. These new genomes have the smallest estimated size (2.2 Mb) and average intergenic spacer length (20 bp) of any previously sequenced freshwater Synechococcus, which may contribute to their success in oligotrophic freshwater systems...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28675306/express-use-of-monte-carlo-simulation-as-a-tool-for-non-destructive-ed-xrf-analysis-of-archaeological-copper-based-artifacts-from-the-chalcolithic-site-of-perdig%C3%A3%C2%B5es-southern-portugal
#9
Carlo Emanuele Bottaini, Antonio Brunetti, Ignacio Montero Ruiz, António Valera, Antonio Candeias, José Mirão
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28673248/transcriptome-analysis-of-haloquadratum-walsbyi-vanity-is-but-the-surface
#10
Henk Bolhuis, Ana Belén Martín-Cuadrado, Riccardo Rosselli, Lejla Pašić, Francisco Rodriguez-Valera
BACKGROUND: Haloquadratum walsbyi dominates saturated thalassic lakes worldwide where they can constitute up to 80-90% of the total prokaryotic community. Despite the abundance of the enigmatic square-flattened cells, only 7 isolates are currently known with 2 genomes fully sequenced and annotated due to difficulties to grow them under laboratory conditions. We have performed a transcriptomic analysis of one of these isolates, the Spanish strain HBSQ001 in order to investigate gene transcription under light and dark conditions...
July 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28643787/single-virus-genomics-reveals-hidden-cosmopolitan-and-abundant-viruses
#11
Francisco Martinez-Hernandez, Oscar Fornas, Monica Lluesma Gomez, Benjamin Bolduc, Maria Jose de la Cruz Peña, Joaquín Martínez Martínez, Josefa Anton, Josep M Gasol, Riccardo Rosselli, Francisco Rodriguez-Valera, Matthew B Sullivan, Silvia G Acinas, Manuel Martinez-Garcia
Microbes drive ecosystems under constraints imposed by viruses. However, a lack of virus genome information hinders our ability to answer fundamental, biological questions concerning microbial communities. Here we apply single-virus genomics (SVGs) to assess whether portions of marine viral communities are missed by current techniques. The majority of the here-identified 44 viral single-amplified genomes (vSAGs) are more abundant in global ocean virome data sets than published metagenome-assembled viral genomes or isolates...
June 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28633685/cross-validation-analysis-for-genetic-evaluation-models-for-ranking-in-endurance-horses
#12
S García-Ballesteros, L Varona, M Valera, J P Gutiérrez, I Cervantes
Ranking trait was used as a selection criterion for competition horses to estimate racing performance. In the literature the most common approaches to estimate breeding values are the linear or threshold statistical models. However, recent studies have shown that a Thurstonian approach was able to fix the race effect (competitive level of the horses that participate in the same race), thus suggesting a better prediction accuracy of breeding values for ranking trait. The aim of this study was to compare the predictability of linear, threshold and Thurstonian approaches for genetic evaluation of ranking in endurance horses...
June 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28627719/the-frontal-assessment-battery-in-clinical-practice-a-systematic-review
#13
REVIEW
Miriam Hurtado-Pomares, M Carmen Terol-Cantero, Alicia Sánchez-Pérez, Paula Peral-Gómez, Desirée Valera-Gran, Eva María Navarrete-Muñoz
BACKGROUND: The frontal assessment battery (FAB) is a brief tool designed to evaluate executive function. Some studies have particularly focused on assessing its applicability addressing two issues: first, on detecting the brain regions responsible for the FAB performance, and second, on determining its capability for differential diagnosis. Our aim was to summarize and analyze critically the studies that assessed the neuroanatomical correspondence and the differential diagnostic value of the FAB in several study populations suffering from different pathologies...
June 19, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28625117/factors-associated-to-health-care-service-use-among-latino-day-laborers
#14
Javier Francisco Boyas, Nalini Junko Negi, Pamela Valera
Latino day laborers (LDLs) are at elevated risks for disease and injury because of the environments in which they work. Despite this recognition, a comprehensive examination of factors related to LDLs' health service use remains unexamined. Using the Andersen model, the current exploratory study examined predisposing (age, education level, location of educational training, legal status, and marital status), enabling (income, trust in medical personnel, whether the respondent has someone they consider their personal doctor, and whether their doctor speaks the same language, perceived barriers to care), and need (self-rated health, number of chronic conditions) variables to predict use of health services among a purposive sample of LDLs ( N = 150)...
July 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28606669/effectiveness-in-the-removal-of-endotoxins-and-microbiological-profile-in-primary-endodontic-infections-using-3-different-instrumentation-systems-a-randomized-clinical-study
#15
Daiana Cavalli, Cássia Cestari Toia, Esteban Isai Flores Orozco, Rayana Duarte Khoury, Flávia Goulart da Rosa Cardoso, Marcelo Corrêa Alves, Cláudio Antônio Talge Carvalho, Marcia Carneiro Valera
INTRODUCTION: This clinical study was conducted to correlate the microbiological profile and levels of endotoxins found in primary endodontic infection with the presence of clinical features and to evaluate the removal of microorganisms and endotoxins using rotary, reciprocating, and hybrid systems for biomechanical preparation. METHODS: Thirty single root canals with primary endodontic infection were evaluated with signs and symptoms and were randomly divided into 3 groups according to the instrumentation system used (n = 10) as follows: rotary Mtwo instruments (VDW, Munich, Germany) with 8 files, the reciprocating Reciproc system (VDW) with a single file, and Genius hybrid instruments with 3 files (1 rotary and 2 reciprocating files) with irrigation using 24 mL 2...
June 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28594531/soft-tissue-tumors-a-pictorial-and-case-based-guide-to-diagnosis-and-management
#16
Valerae O Lewis, Adam S Levin, Ginger E Holt, Timothy A Damron, Scott D Weiner, Carol D Morris
General orthopaedic surgeons must learn how to appropriately evaluate patients with soft-tissue masses who present at their office. Although the incidence of benign soft-tissue sarcomas substantially outnumbers that of malignant soft-tissue sarcomas, the mismanagement of soft-tissue tumors markedly increases a patient's morbidity. The appropriate use of imaging modalities helps general orthopaedic surgeons accurately diagnose a soft-tissue mass, initiate appropriate management of a soft-tissue mass, and gain a better understanding of which patients with soft-tissue lesions should be referred to an orthopaedic oncologist...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28590076/solvent-directed-helical-stereomutation-discloses-pathway-complexity-on-n-heterotriangulene-based-organogelators
#17
Jorge S Valera, Roberto Sánchez-Naya, Francisco J Ramírez, José Luis Zafra, Rafael Gómez, Juan Casado, Luis- Sanchez
The chiroptical features of the supramolecular polymers formed by N-heterotriangulenes 1-3 have been investigated by CD and VCD dichroic techniques. In solution, the CD spectra demonstrate that the helicity of the aggregates depends only on the stereogenic centres located at the peripheral chains. In the gel state, the chiroptical features are conditioned by the point chirality of the stereogenic centres and also by the achiral solvent utilized. The sonication of the gels formed in CCl4 discloses both kinetic and thermodynamic phases...
June 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28583103/in-patient-costs-of-agitation-and-containment-in-a-mental-health-catchment-area
#18
Antoni Serrano-Blanco, Maria Rubio-Valera, Ignacio Aznar-Lou, Luisa Baladón Higuera, Karina Gibert, Alfredo Gracia Canales, Lisette Kaskens, José Miguel Ortiz, Luis Salvador-Carulla
BACKGROUND: There is a scarce number of studies on the cost of agitation and containment interventions and their results are still inconclusive. We aimed to calculate the economic consequences of agitation events in an in-patient psychiatric facility providing care for an urban catchment area. METHODS: A mixed approach combining secondary analysis of clinical databases, surveys and expert knowledge was used to model the 2013 direct costs of agitation and containment events for adult inpatients with mental disorders in an area of 640,572 adult inhabitants in South Barcelona (Spain)...
June 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28552558/llgl1-connects-cell-polarity-with-cell-cell-adhesion-in-embryonic-neural-stem-cells
#19
Yves Jossin, Minhui Lee, Olga Klezovitch, Elif Kon, Alexia Cossard, Wen-Hui Lien, Tania E Fernandez, Jonathan A Cooper, Valera Vasioukhin
Malformations of the cerebral cortex (MCCs) are devastating developmental disorders. We report here that mice with embryonic neural stem-cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1(fl/fl)), a mammalian ortholog of the Drosophila cell polarity gene lgl, exhibit MCCs resembling severe periventricular heterotopia (PH). Immunohistochemical analyses and live cortical imaging of PH formation revealed that disruption of apical junctional complexes (AJCs) was responsible for PH in Nestin-Cre/Llgl1(fl/fl) brains...
June 5, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28541777/multidimensional-determinants-of-the-caregiving-burden-among-chinese-male-caregivers-of-older-family-members-in-hong-kong
#20
Xue Bai, Chang Liu, Luisa Baladon, Maria Rubio-Valera
OBJECTIVES: The objective of this study was to examine multidimensional determinants of the caregiving burden among Chinese male caregivers of older family members in Hong Kong. Based on a modified stress process model, this study explored how background and contextual factors (demographic characteristics and mental health status of caregivers, caregiving-related factors, and support and services), primary stressors (degree of care dependency and special care needs), and secondary stressors (self-efficacy and gender role conflict) might affect the caregiving burden among male caregivers...
May 25, 2017: Aging & Mental Health
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