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https://www.readbyqxmd.com/read/28086964/anti-%C3%AE-synuclein-immunotherapy-reduces-%C3%AE-synuclein-propagation-in-the-axon-and-degeneration-in-a-combined-viral-vector-and-transgenic-model-of-synucleinopathy
#1
Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A Rissman, Eliezer Masliah
Neurodegenerative disorders such as Parkinson's Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons. Recent studies have proposed that neuron-to-neuron propagation of α-syn plays a role in the pathogenesis of these disorders. We have previously shown that antibodies against the C-terminus of α-syn reduce the intra-neuronal accumulation of α-syn and related deficits in transgenic models of synucleinopathy, probably by abrogating the axonal transport and accumulation of α-syn in in vivo models...
January 13, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28057080/combination-of-alpha-synuclein-immunotherapy-with-anti-inflammatory-treatment-in-a-transgenic-mouse-model-of-multiple-system-atrophy
#2
Elvira Valera, Brian Spencer, Jerel A Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Masliah
Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no efficient treatments currently available for MSA patients. We hypothesize that combining therapies targeting different aspects of the disease may lead to better clinical outcomes. To test this hypothesis, we combined the use of a single-chain antibody targeting α-syn modified for improved central nervous system penetration (CD5-D5) with an unconventional anti-inflammatory treatment (lenalidomide) in the myelin basic protein (MBP)-α-syn transgenic mouse model of MSA...
January 5, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28056800/networking-in-microbes-conjugative-elements-and-plasmids-in-the-genus-alteromonas
#3
Mario López-Pérez, Nieves Ramon-Marco, Francisco Rodriguez-Valera
BACKGROUND: To develop evolutionary models for the free living bacterium Alteromonas the genome sequences of isolates of the genus have been extensively analyzed. However, the main genetic exchange drivers in these microbes, conjugative elements (CEs), have not been considered in detail thus far. In this work, CEs have been searched in several complete Alteromonas genomes and their sequence studied to understand their role in the evolution of this genus. Six genomes are reported here for the first time...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28040333/signs-and-symptoms-of-rheumatic-diseases-as-first-manifestation-of-pediatric-cancer-diagnosis-and-prognosis-implications
#4
Mariana Bertoldi Fonseca, Francisco Hugo Rodrigues Gomes, Elvis Terci Valera, Gecilmara Salviato Pileggi, Paula Braga Gonfiantini, Marcela Braga Gonfiantini, Virgínia Paes Leme Ferriani, Luciana Martins de Carvalho
OBJECTIVE: To assess the prevalence and describe the clinical, laboratory and radiological findings, treatment and outcome of children with cancer initially referred to a tertiary outpatient pediatric rheumatology clinic. METHODS: Retrospective analysis of medical records from patients identified in a list of 250 new patients attending the tertiary Pediatric Rheumatology Clinic, Ribeirão Preto Medical School hospital, University of São Paulo, from July 2013 to July 2015, whose final diagnosis was cancer...
December 16, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28029052/diagnosis-management-and-mortality-in-acute-aortic-syndrome-results-of-the-spanish-registry-of-acute-aortic-syndrome-resa-ii
#5
Arturo Evangelista, José Manuel Rabasa, Victor X Mosquera, Antonio Barros, Ruben Fernández-Tarrio, Francisco Calvo-Iglesias, Carlos Ferrera, Jose Rozado, Jordi López-Ayerbe, Carmen Garrote, Jose-Alberto Sanroman, Francisco Nistal, Violeta Sanchez, Jose-Antonio García Robles, Francisco Valera, Carlos Ballester, Oscar Gil-Albarova, Francisco Domínguez, Ricardo Vivancos, Alicia Mateo-Martinez, Pastora Gallego, Mercedes González-Molina, Covadonga Fernández-Golfin, Miguel Josa, Aquilino Hurlé, Ibon Rodríguez-Sanchez, Jose Rodríguez-Palomares
BACKGROUND: Recent advances in the diagnosis and treatment of acute aortic syndrome should improve the outcome of this disease. The Spanish Registry of Acute Aortic Syndrome aimed to assess current results in acute aortic syndrome management in a wide cohort of hospitals in the same geographical area. METHODS: From January 2012 to January 2014, 26 tertiary hospitals included 629 consecutive patients with acute aortic syndrome: 73% men, mean age 64.7±14 years (range 22-92), 443 type A (70...
December 1, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28027663/hiv-risk-inside-u-s-prisons-a-systematic-review-of-risk-reduction-interventions-conducted-in-u-s-prisons
#6
Pamela Valera, Yvonne Chang, Zi Lian
HIV prevalence in correctional populations is approximately five times that of the general adult population. This systematic review examines the broad question of HIV prevention and interventions to reduce inmate HIV-related risk behaviors in U.S. federal and state prisons. We conducted a systematic review of multiple databases and Google Scholar to identify behavioral, biomedical, social, and policy studies related to HIV among U.S. prison populations from 1980-2014. Studies were excluded if they did not focus on HIV, prison inmates, if they were conducted outside of the U...
December 27, 2016: AIDS Care
https://www.readbyqxmd.com/read/27982236/limewater-and-polymyxin-b-associated-with-naocl-for-endotoxin-detoxification-in-root-canal-with-necrotic-pulp
#7
Alessandra Sverberi Carvalho, Luciane Dias de Oliveira, Flávia Goulart da Rosa Cardoso, Felipe Eduardo de Oliveira, Marcia Carneiro Valera, Cláudio Antônio Talge Carvalho
This clinical study investigated the effects of endodontic treatment by using different irrigants (limewater + NaOCl and polymyxin B + NaOCl) and intracanal medication on endotoxins in teeth with primary endodontic infection and radiographically visible apical periodontitis. Thirty-three teeth with necrotic pulp and periapical lesions from different patients were selected for this study. Samples were collected after the coronal opening (S1) and after instrumentation (S2). Root canals were divided in 3 groups (n = 11) according to the irrigant combination used: NaOCl + LW: 2...
September 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27971382/inpatient-costs-of-agitation-and-containment-in-an-urban-area
#8
A Serrano-Blanco, M Rubio-Valera, I Aznar, L Baladón, K Gibert, A Gracia, J M Ortiz, L Kaskens, L Salvador-Carulla
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27969280/effet-de-l%C3%A2-est%C3%A3-trol-sur-la-structure-et-la-fonction-de-vagins-murins
#9
T Benoit, M Valéra, J Arnal, M Soulié, F Boudou, M Buscato, I Raymond-Letron, X Game
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27942999/a-pilot-trial-examining-african-american-and-white-responses-to-algorithm-guided-smoking-cessation-medication-selection-in-persons-living-with-hiv
#10
Pamela Valera, F Joseph McClernon, Greer Burkholder, Michael J Mugavero, James Willig, Conall O'Cleirigh, Karen L Cropsey
Algorithm-based treatments (AT) may be an effective clinical tool to aid HIV clinicians in prescribing pharmacotherapy to increase smoking cessation among people living with HIV (PLWH). Initial results from AT indicated significant increases in abstinence self-efficacy and medication utilization and declines in cigarettes smoked per day across time. Given historical racial disparities, it is unclear if both African Americans and White smokers would benefit equally from this type of intervention. Thus, the aim of this study was to examine racial differences in response to AT guided smoking cessation for African American and White smokers living with HIV...
December 9, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27897087/nuclear-imaging-of-thrombosis-in-small-animal
#11
Marie-Cécile Valéra, Bernard Payrastre, Olivier Lairez
Thromboembolic disorders are a major cause of morbidity and mortality worldwide. The progress in noninvasive imaging techniques has led to the development of radionuclide imaging based on SPECT and PET approaches to observe molecular and cellular processes that may underlie the onset and progression of disease. The advantages of using normal and genetically modified small animal research have spurred the development of dedicated small animal imaging systems. Animal models of venous and arterial thrombosis are largely used and have improved our understanding of the etiology and pathogenesis of thrombosis...
November 29, 2016: Platelets
https://www.readbyqxmd.com/read/27887817/is-there-a-role-for-regenerative-medicine-in-chronic-rhinosinusitis-with-nasal-polyps
#12
EDITORIAL
Fabiana C P Valera, Leandra M Endam, Badr Ibrahim, Emmanuelle Brochiero, Martin Y Desrosiers
No abstract text is available yet for this article.
November 2, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27871135/fire-modifies-the-phylogenetic-structure-of-soil-bacterial-co-occurrence-networks
#13
Eduardo Pérez-Valera, Marta Goberna, Karoline Faust, Jeroen Raes, Carlos García, Miguel Verdú
Fire alters ecosystems by changing the composition and community structure of soil microbes. The phylogenetic structure of a community provides clues about its main assembling mechanisms. While environmental filtering tends to reduce the community phylogenetic diversity by selecting for functionally (and hence phylogenetically) similar species, processes like competitive exclusion by limiting similarity tend to increase it by preventing the coexistence of functionally (and phylogenetically) similar species...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27860075/comparison-between-urine-culture-profile-and-morphology-classification-using-fluorescence-parameters-of-the-sysmex-uf-1000i-urine-flow-cytometer
#14
G Jiménez-Guerra, V Heras-Cañas, M D Valera-Arcas, J Rodríguez-Grangér, J M Navarro, J Gutiérrez-Fernández
AIMS: To determine the usefulness of the fluorescence parameters generated by Sysmex UF-1000i flow cytometer for the rapid diagnosis of urinary tract infection by bacilli or cocci. METHODS AND RESULTS: Urine samples (n = 1924) were studied by culture and microbiology and subsequently by cytometry, using BACT-Morph software and considering forward-scattered light (FSC) and fluorescent light scatter fluorescence parameters. BACT-Morph software showed moderate diagnostic accuracy (78·4%) to detect rod-shaped bacteria, with sensitivity of 82·4% and specificity of 62·5%...
November 18, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27856733/spontaneous-default-network-activity-reflects-behavioral-variability-independent-of-mind-wandering
#15
Aaron Kucyi, Michael Esterman, Clay S Riley, Eve M Valera
The brain's default mode network (DMN) is highly active during wakeful rest when people are not overtly engaged with a sensory stimulus or externally oriented task. In multiple contexts, increased spontaneous DMN activity has been associated with self-reported episodes of mind-wandering, or thoughts that are unrelated to the present sensory environment. Mind-wandering characterizes much of waking life and is often associated with error-prone, variable behavior. However, increased spontaneous DMN activity has also been reliably associated with stable, rather than variable, behavior...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27845811/life-review-when-course-assignments-change-lives
#16
Valera Dee Smith Lester, Donald Dee Kautz
No abstract text is available yet for this article.
November 15, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27831545/neuroimaging-findings-in-mowat-wilson-syndrome-a-study-of-54-patients
#17
Livia Garavelli, Ivan Ivanovski, Stefano Giuseppe Caraffi, Daniela Santodirocco, Marzia Pollazzon, Duccio Maria Cordelli, Ebtesam Abdalla, Patrizia Accorsi, Margaret P Adam, Chiara Baldo, Allan Bayat, Elga Belligni, Federico Bonvicini, Jeroen Breckpot, Bert Callewaert, Guido Cocchi, Goran Cuturilo, Koenraad Devriendt, Mary Beth Dinulos, Olivera Djuric, Roberta Epifanio, Francesca Faravelli, Debora Formisano, Lucio Giordano, Marina Grasso, Sabine Grønborg, Alessandro Iodice, Lorenzo Iughetti, Didier Lacombe, Massimo Maggi, Baris Malbora, Isabella Mammi, Sebastien Moutton, Rikke Møller, Petra Muschke, Manuela Napoli, Chiara Pantaleoni, Rosario Pascarella, Alessandro Pellicciari, Maria Luisa Poch-Olive, Federico Raviglione, Francesca Rivieri, Carmela Russo, Salvatore Savasta, Gioacchino Scarano, Angelo Selicorni, Margherita Silengo, Giovanni Sorge, Luigi Tarani, Luis Gonzaga Tone, Annick Toutain, Aurelien Trimouille, Elvis Terci Valera, Samantha Schrier Vergano, Nicoletta Zanotta, Marcella Zollino, William B Dobyns, Alex R Paciorkowski
PURPOSE: Mowat-Wilson syndrome (MWS) is a genetic disease characterized by distinctive facial features, moderate to severe intellectual disability, and congenital malformations, including Hirschsprung disease, genital and eye anomalies, and congenital heart defects, caused by haploinsufficiency of the ZEB2 gene. To date, no characteristic pattern of brain dysmorphology in MWS has been defined. METHODS: Through brain magnetic resonance imaging (MRI) analysis, we delineated a neuroimaging phenotype in 54 MWS patients with a proven ZEB2 defect, compared it with the features identified in a thorough review of published cases, and evaluated genotype-phenotype correlations...
November 10, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27809679/induction-of-both-local-immune-response-in-mice-and-protection-in-a-rabbit-model-by-intranasal-immunization-with-modified-vaccinia-ankara-virus-expressing-a-secreted-form-of-bovine-herpesvirus-1-glycoprotein-d
#18
María Paula Del Medico Zajac, Flavia Adriana Zanetti, María Soledad Esusy, Carlos Rodolfo Federico, Osvaldo Zabal, Alejandro Rafael Valera, Gabriela Calamante
In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D (MVA-gDs) without addition of adjuvant in two animal models. First, we demonstrated the capability of MVA-gDs of inducing both local and systemic anti-gD humoral immune response after intranasal immunization of mice. Then, we confirmed that two doses of MVA-gDs administered intranasally to rabbits induced systemic anti-gD antibodies and conferred protection against BoHV-1 challenge...
January 2017: Viral Immunology
https://www.readbyqxmd.com/read/27804017/is-it-appropriate-to-treat-sarcoma-metastases-with-intramedullary-nailing
#19
Bryan S Moon, Dwayne J Dunbar, Patrick P Lin, Robert L Satcher, Justin E Bird, Valerae O Lewis
BACKGROUND: Patients with primary bone and soft tissue sarcoma are at risk for skeletal metastases. Although uncommon, these metastases can result in impending or pathologic fractures. Intramedullary nailing traditionally has been an accepted form of palliative treatment for patients with metastatic carcinoma, but we could find no studies that report specifically on intramedullary nailing of metastatic sarcoma lesions. QUESTIONS/PURPOSES: We asked: (1) What is the survival of patients with an impending or pathologic fracture from a sarcoma metastasis? (2) What proportion of patients treated with intramedullary nailing subsequently underwent a revision procedure or nail removal during their lifetimes? METHODS: Between 1996 and 2014, we performed 40 intramedullary nailing procedures in 34 patients with multifocal metastases from sarcomas who showed signs or symptoms of impending fracture or who presented with a pathologic fracture...
January 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27766587/brain-injury-in-women-experiencing-intimate-partner-violence-neural-mechanistic-evidence-of-an-invisible-trauma
#20
Eve Valera, Aaron Kucyi
Traumatic brain injury (TBI) in women experiencing intimate-partner violence (IPV) is common, and IPV afflicts 30 % of women worldwide. However, the neurobiology and related sequelae of these TBIs have never been systematically examined. Consequently, TBI treatments are typically absent and IPV interventions are inadequate. There has been a call for a comprehensive assessment of IPV-related TBIs and their relationship to aspects of women's cognitive and neural functioning. In response, we examined brain-network organization associated with TBI and its cognitive effects using clinical interviews and neuropsychological measures as well as structural and functional Magnetic Resonance Imaging (fMRI) in women experiencing IPV-related TBI...
October 20, 2016: Brain Imaging and Behavior
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