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Emily C Soriano, Rosmeiry Valera, Elizabeth C Pasipanodya, Amy K Otto, Scott D Siegel, Jean-Philippe Laurenceau
Background: Fear of cancer recurrence (FCR) is a top ongoing concern of breast cancer (BC) survivors and thus the focus of recent intervention development. The Self-Regulation Model of FCR (Lee-Jones C, Humphris G, Dixon R, Hatcher MB. Fear of cancer recurrence-a literature review and proposed cognitive formulation to explain exacerbation of recurrence fears. Psychooncology. 1997;6:95-105.) states that everyday cancer-related events trigger FCR, which, in turn, leads to specific behavioral responses, including checking the body for signs or symptoms of cancer...
May 16, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
Aimee Burke Valeras
No abstract text is available yet for this article.
May 2018: Family Medicine
Vanessa Terezinha Gubert de Matos, Fabiani de Morais Batista, Naiara Valera Versage, Clarice Souza Pinto, Vanessa Marcon de Oliveira, Érica Freire de Vasconcelos Pereira, Roberta Barbeta Dos Rios de Matos, Márcia Maria Ferrairo Janini Dal Fabbro, Ana Lúcia Lyrio de Oliveira
OBJECTIVES: To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission. METHODS: A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants. RESULTS: A total of 218 births of 176 HIV-infected pregnant women were identified during the study period, of which 187 infants were exposed and uninfected, 19 seroconverted, and 12 were still inconclusive in July 2015...
May 9, 2018: Brazilian Journal of Infectious Diseases
Marie-Cécile Valéra, Coralie Fontaine, Marion Dupuis, Emmanuelle Noirrit-Esclassan, Alexia Vinel, Maeva Guillaume, Pierre Gourdy, Françoise Lenfant, Jean-François Arnal
Women now spend more than one-third of their lives in the postmenopausal years, and the decline of endogenous estrogen production during menopause is accompanied by a series of functional disorders that affect the quality of life. These symptoms could be alleviated or even totally suppressed by menopausal hormone therapy (MHT), initially based on natural estrogens extracted from the urine of pregnant mares (mainly in the USA, using the oral route) and later from the synthesis of the natural estrogen, 17β-estradiol (mainly in Europe, in particular using the transdermal route)...
May 3, 2018: Pharmacology & Therapeutics
Rex Cole, Valera Peremyslov, Savanah Van Why, Ibrahim Moussaoui, Ann Ketter, Renee Cool, Matthew Andres Moreno, Zuzana Vejlupkova, Valerian Dolja, John E Fowler
The exocyst, a conserved, octameric protein complex helps mediate secretion at the plasma membrane, facilitating specific developmental processes that include control of root meristem size, cell elongation, and tip growth. A genetic screen for second-site enhancers in Arabidopsis identified NEW ENHANCER of ROOT DWARFISM1 (NERD1) as an exocyst interactor. Mutations in nerd1 combined with weak exocyst mutations in SEC8 and EXO70A1 result in a synergistic reduction in root growth. Alone, nerd1 alleles modestly reduce primary root growth, both by shortening the root meristem and by reducing cell elongation, but also result in a slight increase in root hair length, bulging, and rupture...
May 2, 2018: Journal of Experimental Botany
Suzanne Kafaja, Isela Valera, Anagha A Divekar, Rajan Saggar, Fereidoun Abtin, Daniel E Furst, Dinesh Khanna, Ram Raj Singh
Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear. We demonstrate that, in animals and humans with systemic fibrosis, plasmacytoid DCs (pDCs) are unaffected or are reduced systemically (spleen/peripheral blood), but they increase in the affected organs (lungs/skin/bronchoalveolar lavage). A pivotal role of pDCs was shown by depleting them in vivo, which ameliorated skin and/or lung fibrosis, reduced immune cell infiltration in the affected organs but not in spleen, and reduced the expression of genes and proteins implicated in chemotaxis, inflammation, and fibrosis in the affected organs of animals with bleomycin-induced fibrosis...
May 3, 2018: JCI Insight
Anais Grangeray-Vilmint, Antoine M Valera, Arvind Kumar, Philippe Isope
The balance between excitation (E) and inhibition (I) in neuronal networks controls the firing rate of principal cells through simple network organization, such as feedforward inhibitory circuits. Here, we demonstrate in male mice, that at the granule cell (GrC)-molecular layer interneuron (MLI)-Purkinje cell (PC) pathway of the mouse cerebellar cortex, E/I balance is dynamically controlled by short-term dynamics during bursts of stimuli, shaping cerebellar output. Using a combination of electrophysiological recordings, optogenetic stimulation and modeling, we describe the wide range of bidirectional changes in PC discharge triggered by GrC bursts, from robust excitation to complete inhibition...
May 2, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Romaric Bonnet, Carole Farre, Lionel Valera, Ludivine Vossier, Fanny Léon, Typhaine Dagland, Agnès Pouzet, Nicole Jaffrézic-Renault, Jeannette Fareh, Chantal Fournier-Wirth, Carole Chaix
A nanoparticle-based electrochemical sandwich immunoassay was developed for bacteria detection in platelet concentrates. For the assay, magnetic beads were functionalized with antibodies to allow the specific capture of bacteria from the complex matrix, and innovative methylene blue-DNA/nanoparticle assemblies provided the electrochemical response for amplified detection. This nanoparticular system was designed as a temperature-sensitive nano-tool for electrochemical detection. First, oligonucleotide-functionalized nanoparticles were obtained by direct synthesis of the DNA strands on the nanoparticle surface using an automated oligonucleotide synthesizer...
April 24, 2018: Analyst
G Anaya, M E Fernández, M Valera, A Molina, F Azcona, P Azor, M Solé, M Moreno-Millán, S Demyda-Peyrás
Twin foaling is associated with chimaerism in several domestic species and is recognised in horses. In this study, 21,097 purebred Spanish (Pura Raza Español) horse births from the 2015 to 2016 breeding season were investigated for chimaerism. Twin foaled and chimaeric individuals were assessed on the basis of foaling records, short-tandem repeat (STR) parentage test results and a sex-linked STR-based technique. Fourteen twin pregnancies with 23 twin foals born alive were identified (0.066% twin foaling prevalence), including five blood chimaeric cases (21...
April 2018: Veterinary Journal
Dave Singh, Peter J Barnes, Robert Stockley, Maria Victorina Lopez Valera, Claus Vogelmeier, Alvar Agusti
No abstract text is available yet for this article.
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Monique Costa Moreira França, Tânia Mara Da Silva, Gleyce Oliveira Silva, Márcia Carneiro Valera, Carlos Henrique Ribeiro Camargo
BACKGROUND/AIMS: Dental root cell proliferation following tooth avulsion has not been well researched. Understanding the effects of dry time and dentin treatment influences on cell proliferation is essential to provide evidence-based guidelines for tooth replantation. The study evaluated the viability of periodontal ligament fibroblasts (PLF) in contact with roots, submitted to surface treatments with EDTA and hyaluronic acid (HA) at different times, including to quantify inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α expressed by PLF...
April 17, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Enrique Valera, Jacob Berger, Umer Hassan, Tanmay Ghonge, Julia Liu, Michael Rappleye, Jackson Winter, Daniel Abboud, Zeeshan Haidry, Ryan Healey, Na-Teng Hung, Nathaniel Leung, Naif Mansury, Alexander Hasnain, Christine Lannon, Zachary Price, Karen White, Rashid Bashir
Sepsis, an adverse auto-immune response to an infection often causing life-threatening complications, results in the highest mortality and treatment cost of any illness in US hospitals. Several immune biomarker levels, including Interleukin 6 (IL-6), have shown a high correlation to the onset and progression of sepsis. Currently, no technology diagnoses and stratifies sepsis progression using biomarker levels. This paper reports a microfluidic biochip platform to detect proteins in undiluted human plasma samples...
April 17, 2018: Lab on a Chip
A Vinel, A E Coudert, M Buscato, M C Valera, Ostertag Agnès, J A Katzenellenbogen, B S Katzenellenbogen, A Berdal, S Babajko, J F Arnal, C Fontaine
Estrogens play an important role in bone growth and maturation as well as in the regulation of bone turnover in adults. Although the effects of 17β-estradiol (E2) are well documented in long bones and vertebrae, little is known regarding its action in the mandible. E2 actions could be mediated by estrogen receptor (ER) α or β. ERs act primarily as transcriptional factors through two activation functions (AF)-1 and 2, but they can also elicit membrane-initiated steroid signaling (MISS). The aim of the present study was to define ER pathways involved in E2 effects on mandibular bone...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Eva María Navarrete-Muñoz, Laura Torres-Collado, Desirée Valera-Gran, Sandra Gonzalez-Palacios, Laura María Compañ-Gabucio, Sergio Hernández-Sánchez, Manuela García-de-la-Hera
The aim of this study was to identify determinants of the nutrition labelling (NL) use and explore its association with the adherence to Mediterranean Diet (MD) in Spanish health university students. We performed a cross-sectional analysis of the baseline data from 1026 university students aged 17-35 years enrolled in the DiSA-UMH (Dieta, Salud y Antropometría-Universidad Miguel Hernández) cohort study. Students were asked about their NL use by the following question: "Do you usually read the nutrition labelling of packaged foods?" (No, Yes)...
April 3, 2018: Nutrients
Aimee Burke Valeras
Provides the nomination letter of Mary Talen, PhD, for the 2017 CFHA's Don Bloch Award. Dr. Mary Talen is a psychologist with an unwavering ability to see the humanness of every individual who interacts with the community health center and residency she works at-patient, staff, faculty, or resident-and her perspective impacts everyone that surrounds her. The nomination details her intellectual, behavioral, and relational qualities as a professional. (PsycINFO Database Record
March 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
Otávio Bejzman Piltcher, Eduardo Macoto Kosugi, Eulalia Sakano, Olavo Mion, José Ricardo Gurgel Testa, Fabrizio Ricci Romano, Marco Cesar Jorge Santos, Renata Cantisani Di Francesco, Edson Ibrahim Mitre, Thiago Freire Pinto Bezerra, Renato Roithmann, Francini Greco Padua, Fabiana Cardoso Pereira Valera, José Faibes Lubianca Neto, Leonardo Conrado Barbosa Sá, Shirley Shizue Nagata Pignatari, Melissa Ameloti Gomes Avelino, Juliana Alves de Souza Caixeta, Wilma Terezinha Anselmo-Lima, Edwin Tamashiro
INTRODUCTION: Bacterial resistance burden has increased in the past years, mainly due to inappropriate antibiotic use. Recently it has become an urgent public health concern due to its impact on the prolongation of hospitalization, an increase of total cost of treatment and mortality associated with infectious disease. Almost half of the antimicrobial prescriptions in outpatient care visits are prescribed for acute upper respiratory infections, especially rhinosinusitis, otitis media, and pharyngotonsillitis...
February 25, 2018: Brazilian Journal of Otorhinolaryngology
Marc El Beaino, Jason Roszik, John A Livingston, Wei-Lien Wang, Alexander J Lazar, Behrang Amini, Vivek Subbiah, Valerae Lewis, Anthony P Conley
Mesenchymal chondrosarcoma is a rare but deadly form of chondrosarcoma that typically affects adolescents and young adults. While curative intent is possible for patients with localized disease, few options exist for patients in the unresectable/metastatic setting. Thus, it is imperative to understand the fusion-driven biology of this rare malignant neoplasm so as to lead to the future development of better therapeutics for this disease. This manuscript will briefly review the clinical and pathologic features of mesenchymal chondrosarcoma followed by an appraisal of existing data linked to the fusions, HEY1-NCOA2 and IRF2BP2-CDX1, and the associated downstream pathways...
March 26, 2018: Current Oncology Reports
Mohamad Abu-Abied, Eduard Belausov, Sapir Hagay, Valera Peremyslov, Valerian Dolja, Einat Sadot
The interplay between myosin- and auxin-mediated processes was investigated by following root development in the triple myosin knockout mutant xi-k xi-1 xi-2 (3KO). It was found that the 3KO plants generated significantly more lateral and adventitious roots than the wild type plants or rescued plant line expressing functional myosin XI-K:YFP (3KOR). Using the auxin-dependent reporter DR5:venus, a significant change in the auxin gradient toward the root tip was found in 3KO plants, which correlated with the loss of polar localization of the auxin transporter PIN1 in the stele and with the increased number of the stele cells with oblique cell walls...
March 22, 2018: Journal of Experimental Botany
Stephanie H Cook, Pamela Valera, Erica P Wood, Benjamin J Calebs, Patrick A Wilson
We conducted a mixed-methods study to identify factors that influence transitions in attachment style between childhood and adulthood among 28 young Black gay and bisexual men (YBGBM) in the United States. We used a phenomenological approach to data integration, with the major component to the results being garnered from the qualitative interviews. We organized our results by four attachment transition groups: stable secure (secure attachment in childhood and young adulthood), stable insecure (insecure attachment in childhood and young adulthood), secure to insecure (secure in childhood and insecure in adulthood) and insecure to secure (insecure in childhood and secure in adulthood)...
March 26, 2018: Journal of Sex Research
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