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Christoph Zinner, David Morales-Alamo, Niels Ørtenblad, Filip J Larsen, Tomas A Schiffer, Sarah J Willis, Miriam Gelabert-Rebato, Mario Perez-Valera, Robert Boushel, Jose A L Calbet, Hans-Christer Holmberg
To elucidate the mechanisms underlying the differences in adaptation of arm and leg muscles to sprint training, over a period of 11 days 16 untrained men performed six sessions of 4-6 × 30-s all-out sprints (SIT) with the legs and arms, separately, with a 1-h interval of recovery. Limb-specific VO2peak, sprint performance (two 30-s Wingate tests with 4-min recovery), muscle efficiency and time-trial performance (TT, 5-min all-out) were assessed and biopsies from the m. vastus lateralis and m. triceps brachii taken before and after training...
2016: Frontiers in Physiology
Stephanie H Cook, Pamela Valera, Benjamin J Calebs, Patrick A Wilson
Objective: The present study examined the moderating effect of adult attachment on the association between childhood traumatic experiences, (i.e., physical abuse, emotional abuse, emotional neglect, and being bullied), age of childhood traumatic experience, and young adult depression symptoms among young Black gay and bisexual men (YBGBM). Method: Self-report measures of attachment, childhood traumatic experiences, and depression symptoms were collected from a community-based sample of YBGBM living in New York City (n = 228)...
October 13, 2016: Cultural Diversity & Ethnic Minority Psychology
Cláudia Maria de Felício, Franciele Voltarelli da Silva Dias, Gislaine Aparecida Folha, Leila Azevedo de Almeida, Jaqueline Freitas de Souza, Wilma Terezinha Anselmo-Lima, Luciana Vitaliano Voi Trawitzki, Fabiana Cardoso Pereira Valera
OBJECTIVES: The purposes of this study were (1) to identify possible differences in muscular and orofacial functions between children with obstructive sleep apnea (OSA) and with primary snoring (PS); (2) to examine the standardized difference between normal values of myofunctional scores and those of subjects with OSA or PS; and (3) to identify the features associated with OSA. METHODS: Participants were 39 children (mean age 8 ± 1.2 years) of which, 27 had a diagnosis of OSA and 12 had PS...
November 2016: International Journal of Pediatric Otorhinolaryngology
Justin E Bird, Lee Jae Morse, Lei Feng, Wei-Lien Wang, Patrick P Lin, Bryan S Moon, Alexander J Lazar, Robert L Satcher, John E Madewell, Valerae O Lewis
PURPOSE: To determine non-radiographic risk factors differentiating atypical lipomatous tumors (ALTs) from lipomas. METHODS: All patients with deep-seated lipomatous tumors of the extremities treated from January 2000 to October 2010 were retrospectively reviewed. Factors reviewed included age, gender, tumor location, size, histology, local recurrence, dedifferentiation, and metastasis. Multivariate logistic regression models were used to evaluate the effects of patient characteristics on ALT status...
2016: Frontiers in Oncology
Winston W Huh, Najat C Daw, Cynthia E Herzog, Mark F Munsell, Mary Frances McAleer, Valerae O Lewis
AIM: Few data exist regarding the clinical characteristics and outcome of young children with Ewing sarcoma family of tumors (ESFT). METHODS: We reviewed the records of ESFT patients at our institution younger than 10 years of age at diagnosis. RESULTS: Forty-two patients were identified. Median age was 6.4 years (range 0.6-9.5 years). Most patients had T2 (>5 cm) tumors (n = 31; 74%). Most common primary site was the extremity (n = 17; 41%)...
October 3, 2016: Pediatric Blood & Cancer
Cristina Díaz Del Arco, J Ángel Díaz Pérez, Luis Ortega Medina, Javier Sastre Valera, M Jesús Fernández Aceñero
Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed all the cases of FNA under EUS control of PanNETs in a 10-year period (2006-2016) in the Hospital Clínico San Carlos (Madrid). We identified 10 PanNET cases with histological correlation. Median age was 49...
September 29, 2016: Endocrine Pathology
Maria Cristina Monti, Davide Guido, Cristina Montomoli, Claudia Sardu, Alessandro Sanna, Salvatore Pretti, Lorena Lorefice, Maria Giovanna Marrosu, Paolo Valera, Eleonora Cocco
BACKGROUND: South-Western Sardinia (SWS) is a high risk area for Multiple Sclerosis (MS) with high prevalence and spatial clustering; its population is genetically representative of Sardinians and presents a peculiar environment. We evaluated the MS environmental risk of specific heavy metals (HM) and geographical factors such as solar UV exposure and urbanization by undertaking a population-based cross-sectional study in SWS. METHODS: Geochemical data on HM, UV exposure, urbanization and epidemiological MS data were available for all SWS municipalities...
2016: PloS One
María Rubio-Valera, Elena Huerta-Ramos, Luisa Baladón, Ignacio Aznar-Lou, José M Ortiz-Moreno, Juan V Luciano, Pere N Roset-Arisso, Luis Salvador-Carulla, José M Villagrán, Fermín Mayoral, Alfredo Gracia, Antoni Serrano-Blanco
INTRODUCTION: Agitation is a common problem in psychiatric care with serious clinical and economic consequences. METHODOLOGY: The aim of the study was to define and characterize the agitation states present in usual medical practice in the acute and emergency units of a psychiatric hospital. Two nominal groups, one with 7 nurses and the other with 10 psychiatrists from the Parc Sanitari Sant Joan de Déu, were established. RESULTS: The nurses described two main states forming the endpoints of a spectrum: from mild (pre-agitation) to severe (agitation)...
September 2016: Actas Españolas de Psiquiatría
Luca Valera, María Teresa Russo, Giuseppe Curcio
More and more seems to be necessary to find new ways of communication between medical doctors and bioethicists in order to build a shared vocabulary and to prevent conflicts: many bioethical problems seem to be caused by the lack of dialogue between them, which both seem to speak two different languages. Improving this dialogue means searching new languages and innovative forms of communication: the narration could be a really effective tool to enhance the physicians' and bioethicist's moral conscience, since it facilitates reasoning on someone's particular experience, and, ultimately, on our experience...
May 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
Marie-Cécile Valéra, Isabelle Aragon, Paul Monsarrat, Fréderic Vaysse, Emmanuelle Noirrit-Esclassan
OBJECTIVE: The aim of this study was to evaluate the attitude of parents towards the oral health of their children before oral rehabilitation under general anesthesia (GA). STUDY DESIGN: Children receiving dental treatment under GA between November 2013 and July 2014 in the Pediatric Dentistry Department (University Hospital Center, Toulouse, France) were enrolled in an oral health preventive program. An anonymous questionnaire was self-administered by the parents during the pre-operative session...
2016: Journal of Clinical Pediatric Dentistry
Henrique Augusto Cantareira Sabino, Fabiana Cardoso Pereira Valera, Davi Casale Aragon, Marina Zilio Fantucci, Carolina Carneiro Titoneli, Roberto Martinez, Wilma T Anselmo-Lima, Edwin Tamashiro
BACKGROUND: The management of acute exacerbation of chronic rhinosinusitis (AECRS) is still under debate, especially because there are no adequate studies to support a best-evidence treatment for this condition. Antibiotic use for AECRS has been recommended based on extrapolation of data from acute rhinosinusitis (ARS) or non-placebo-controlled studies. This study aimed to evaluate whether antibiotic therapy modifies the course of AECRS in a randomized, placebo-controlled study. METHODS: Patients with AECRS were randomized in a double-blinded manner (2:1 ratio) to receive either amoxicillin-clavulanate 875 mg/125 mg twice daily (BID) (AMX-CLAV, n = 21) or placebo capsules (n = 11) during 14 days...
September 9, 2016: International Forum of Allergy & Rhinology
Brian Spencer, Stephanie Williams, Edward Rockenstein, Elvira Valera, Wei Xin, Michael Mante, Jazmin Florio, Anthony Adame, Eliezer Masliah, Michael R Sierks
OBJECTIVE: Progressive accumulation of α-synuclein (α-syn) has been associated with Parkinson's disease (PD) and Dementia with Lewy body (DLB). The mechanisms through which α-syn leads to neurodegeneration are not completely clear; however, the formation of various oligomeric species have been proposed to play a role. Antibody therapy has shown effectiveness at reducing α-syn accumulation in the central nervous system (CNS); however, most of these studies have been conducted utilizing antibodies that recognize both monomeric and higher molecular weight α-syn...
August 2016: Annals of Clinical and Translational Neurology
María Candelaria Ayuso-Raya, Francisco Escobar-Rabadán, Jesús López-Torres-Hidalgo, Julio Montoya-Fernández, Juan Manuel Téllez-Lapeira, Francisco Campa-Valera
CONTEXT AND OBJECTIVE: A cold climate towards primary care (PC) within medical academia could form a barrier against choosing family medicine (FM) as a career option. This study was designed to determine whether medical students' knowledge of and attitudes towards FM predicted their career choice. DESIGN AND SETTING: Cohort study conducted at two different medical schools. METHODS: After completing a PC course at the Albacete Medical School in 2005-2006, 81 second-year students were asked to give responses to a questionnaire...
July 2016: São Paulo Medical Journal, Revista Paulista de Medicina
M Solé, M Valera, M D Gómez, J Sölkner, A Molina, G Mészáros
BACKGROUND: Longevity/durability is a relevant trait in racehorses. Genetic analysis and knowledge of factors that influence number of harness race starts would be advantageous for both horse welfare and the equine industry. OBJECTIVES: To perform a genetic analysis on harness racing using number of races as a measure of longevity/durability and to identify factors associated with career length in Spanish Trotter Horses (STH). STUDY DESIGN: Longitudinal study...
August 27, 2016: Equine Veterinary Journal
Juan Luis Callejas-Valera, Ramiro Iglesias-Bartolome, Panomwat Amornphimoltham, Julia Palacios-Garcia, Daniel Martin, Joseph A Califano, Alfredo A Molinolo, J Silvio Gutkind
The rising incidence of human papillomavirus (HPV)-associated malignancies, especially for oropharyngeal cancers, has highlighted the urgent need to understand how the interplay between high-risk HPV oncogenes and carcinogenic exposure results in squamous cell carcinoma (SCC) development. Here, we describe an inducible mouse model expressing high risk HPV-16 E6/E7 oncoproteins in adults, bypassing the impact of these viral genes during development. HPV-16 E6/E7 genes were targeted to the basal squamous epithelia in transgenic mice using a doxycycline inducible cytokeratin 5 promoter (cK5-rtTA) system...
October 2016: Carcinogenesis
Pamela Valera, Robert Fullilove, Shae Cali, Edward Nunes, Victoria Chiongbian, Wayne Clark, Lirio Covey
The purpose of this study was to assess the factor structure and psychometric properties of the original and a revised modification of the Brief Symptom Inventory (BSI) in 259 black and Latino males, aged thirty-five to sixty-seven, who had been released from a New York state prison or a New York City jail. The data were analysed using exploratory factor analysis, principal axis factoring and confirmatory factor analysis. Standardised factor loadings were evaluated at 0.05, model fit was evaluated using the chi-square statistic, and fit indices were examined...
October 2015: British Journal of Social Work
Rohit Ghai, Maliheh Mehrshad, Carolina Megumi Mizuno, Francisco Rodriguez-Valera
Low-GC Actinobacteria are among the most abundant and widespread microbes in freshwaters and have largely resisted all cultivation efforts. Consequently, their phages have remained totally unknown. In this work, we have used deep metagenomic sequencing to assemble eight complete genomes of the first tailed phages that infect freshwater Actinobacteria. Their genomes encode the actinobacterial-specific transcription factor whiB, frequently found in mycobacteriophages and also in phages infecting marine pelagic Actinobacteria...
August 9, 2016: ISME Journal
Inés Tofé Valera, María Pilar Jaraba Caballero, María Dolores Ruiz González, María Victoria Rodríguez Benítez, María José Parraga Quiles
No abstract text is available yet for this article.
August 4, 2016: Revista Española de Cardiología
Roberto Chalela, José Gregorio González-García, Juan José Chillarón, Leticia Valera-Hernández, Carlos Montoya-Rangel, Diana Badenes, Sergi Mojal, Joaquim Gea
Hyponatremia is the most common electrolyte disorder in hospitalized patients, being associated with increased morbidity and mortality in different clinical conditions. However, the prevalence and impact of this electrolytic disorder in patients hospitalized for an exacerbation of COPD still remains unknown. The aim of the present study was to clarify these points. A total of 424 patients hospitalized due to a COPD exacerbation were consecutively included, showing a frequency of hyponatremia of 15.8% (hyposmolar in most cases)...
August 2016: Respiratory Medicine
Changyoun Kim, Guohua Lv, Jun Sung Lee, Byung Chul Jung, Masami Masuda-Suzukake, Chul-Suk Hong, Elvira Valera, He-Jin Lee, Seung R Paik, Masato Hasegawa, Eliezer Masliah, David Eliezer, Seung-Jae Lee
A single amyloidogenic protein is implicated in multiple neurological diseases and capable of generating a number of aggregate "strains" with distinct structures. Among the amyloidogenic proteins, α-synuclein generates multiple patterns of proteinopathies in a group of diseases, such as Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). However, the link between specific conformations and distinct pathologies, the key concept of the strain hypothesis, remains elusive...
2016: Scientific Reports
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