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https://www.readbyqxmd.com/read/29141117/tunable-energy-landscapes-to-control-pathway-complexity-in-self-assembled-n-heterotriangulenes-living-and-seeded-supramolecular-polymerization
#1
Jorge S Valera, Rafael Gómez, Luis Sánchez
Herein, the synthesis and self-assembling features of N-heterotriangulenes 1-3 decorated in their periphery with 3,4,5-trialkoxy-N-(alkoxy)benzamide moieties that enable kinetic control of the supramolecular polymerization process are described. The selection of an appropriate solvent results in a tunable energy landscape in which the relative energy of the different monomeric or aggregated species can be regulated. Thus, in a methylcyclohexane/toluene (MCH/Tol) mixture, intramolecular hydrogen-bonding interactions in the peripheral side units favor the formation of metastable inactivated monomers that evolve with time at precise conditions of concentration and temperature...
November 15, 2017: Small
https://www.readbyqxmd.com/read/29135665/cryoablation-of-bone-metastases-from-renal-cell-carcinoma-for-local-tumor-control
#2
Carly S Gardner, Joe E Ensor, Kamran Ahrar, Steven Y Huang, Sharjeel H Sabir, Nizar M Tannir, Valerae O Lewis, Alda L Tam
BACKGROUND: Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma. METHODS: We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29125662/how-do-mediterranean-shrub-species-cope-with-shade-ecophysiological-response-to-different-light-intensities
#3
M C Díaz-Barradas, M Zunzunegui, L Alvarez-Cansino, M P Esquivias, J Valera, H Rodríguez
Under natural conditions, light exposition for Mediterranean shrubs can be highly variable, especially during cloudy days or under a canopy, and can interfere with other environmental factors such as temperature and water availability. With the aim of decoupling the effect of radiation and temperature from water availability, we conducted an experiment where 2 perennial and 3 summer semi-deciduous shrub species were subjected to different levels of irradiation. In order to follow plant responses to light exposure, we measured gas exchange, photosystem II photochemical efficiency, photosynthetic pigments, and leaf mass area in spring and summer...
November 10, 2017: Plant Biology
https://www.readbyqxmd.com/read/29123523/identification-of-an-evolutionarily-conserved-ankyrin-domain-containing-protein-caiap-which-regulates-inflammasome-dependent-resistance-to-bacterial-infection
#4
Sylwia D Tyrkalska, Sergio Candel, Ana B Pérez-Oliva, Ana Valera, Francisca Alcaraz-Pérez, Diana García-Moreno, María L Cayuela, Victoriano Mulero
Many proteins contain tandemly repeated modules of several amino acids, which act as the building blocks that form the underlying architecture of a specific protein-binding interface. Among these motifs and one of the most frequently observed is ankyrin repeats (ANK), which consist of 33 amino acid residues that are highly conserved. ANK domains span a wide range of functions, including protein-protein interactions, such as the recruitment of substrate to the catalytic domain of an enzyme, or the assembly of stable multiprotein complexes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29119305/the-development-and-psychometric-properties-of-the-immigration-law-concerns-scale-ilcs-for-hiv-testing
#5
Julia Lechuga, Carol L Galletly, Michelle R Broaddus, Julia B Dickson-Gomez, Laura R Glasman, Timothy L McAuliffe, Miriam Y Vega, Sarah LeGrand, Carla A Mena, Morgan L Barlow, Erik Valera, Judith I Montenegro
To develop, pilot test, and conduct psychometric analyses of an innovative scale measuring the influence of perceived immigration laws on Latino migrants' HIV-testing behavior. The Immigration Law Concerns Scale (ILCS) was developed in three phases: Phase 1 involved a review of law and literature, generation of scale items, consultation with project advisors, and subsequent revision of the scale. Phase 2 involved systematic translation- back translation and consensus-based editorial processes conducted by members of a bilingual and multi-national study team...
November 8, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29117521/sparse-labeling-peldor-spectroscopy-on-multimeric-mechanosensitive-membrane-channels
#6
Katrin Ackermann, Christos Pliotas, Silvia Valera, James H Naismith, Bela E Bode
Pulse electron paramagnetic resonance (EPR) is being applied to ever more complex biological systems comprising multiple subunits. Membrane channel proteins are of great interest as pulse EPR reports on functionally significant but distinct conformational states in a native environment without the need for crystallization. Pulse EPR, in the form of pulsed electron-electron double resonance (PELDOR), using site-directed spin labeling, is most commonly employed to accurately determine distances (in the nanometer range) between different regions of the structure...
November 7, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29089869/microrna-101-modulates-autophagy-and-oligodendroglial-alpha-synuclein-accumulation-in-multiple-system-atrophy
#7
Elvira Valera, Brian Spencer, Jennifer Mott, Margarita Trejo, Anthony Adame, Michael Mante, Edward Rockenstein, Juan C Troncoso, Thomas G Beach, Eliezer Masliah, Paula Desplats
Synucleinopathies, neurodegenerative disorders with alpha-synuclein (α-syn) accumulation, are the second leading cause of neurodegeneration in the elderly, however no effective disease-modifying alternatives exist for these diseases. Multiple system atrophy (MSA) is a fatal synucleinopathy characterized by the accumulation of toxic aggregates of α-syn within oligodendroglial cells, leading to demyelination and neurodegeneration, and the reduction of this accumulation might halt the fast progression of MSA...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29079621/genomes-of-novel-microbial-lineages-assembled-from-the-sub-ice-waters-of-lake-baikal
#8
Pedro J Cabello-Yeves, Tamara I Zemskaya, Riccardo Rosselli, Felipe H Coutinho, Alexandra S Zakharenko, Vadim V Blinov, Francisco Rodriguez-Valera
We present a metagenomic study of Lake Baikal (East Siberia). Two samples obtained from the water column under the ice cover (5 and 20 m deep) in March have been deep sequenced and the reads assembled to generate metagenome assembled genomes (MAGs) that are representative of the microbes living in this special environment. Compared with freshwater bodies studied around the world, Lake Baikal had an unusually high fraction of Verrucomicrobia Other groups such as Actinobacteria or Proteobacteria were in similar proportions as those found in other lakes...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29069155/effects-of-porcelain-thickness-on-the-flexural-strength-and-crack-propagation-in-a-bilayered-zirconia-system
#9
Viviane Maria Gonçalves de Figueiredo, Sarina Maciel Braga Pereira, Eduardo Bressiani, Márcia Carneiro Valera, Marco Antônio Bottino, Yu Zhang, Renata Marques de Melo
OBJECTIVE: This study evaluated the influence of porcelain (VM9, VITA Zahnfabrik, Germany) thickness on the flexural strength and crack propagation in bilayered zirconia systems (YZ, VITA Zahnfabrik, Germany). MATERIAL AND METHODS: Thirty zirconia bars (20.0x4.0x1.0 mm) and six zirconia blocks (12.0x7.5x1.2 mm) were prepared and veneered with porcelain with different thickness: 1 mm, 2 mm, or 3 mm. The bars of each experimental group (n=10) were subjected to four-point flexural strength testing...
September 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29058121/multiple-system-atrophy-experimental-models-and-reality
#10
REVIEW
Cassia Overk, Edward Rockenstein, Elvira Valera, Nadia Stefanova, Gregor Wenning, Eliezer Masliah
Multiple system atrophy (MSA) is a rapidly progressing fatal synucleinopathy of the aging population characterized by parkinsonism, dysautonomia, and in some cases ataxia. Unlike other synucleinopathies, in this disorder the synaptic protein, α-synuclein (α-syn), predominantly accumulates in oligodendroglial cells (and to some extent in neurons), leading to maturation defects of oligodendrocytes, demyelination, and neurodegeneration. The mechanisms through which α-syn deposits occur in oligodendrocytes and neurons in MSA are not completely clear...
October 20, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/29031240/colonization-of-oropharynx-and-lower-respiratory-tract-in-critical-patients-risk-of-ventilator-associated-pneumonia
#11
Ivany Machado de Carvalho Baptista, Frederico Canato Martinho, Gustavo Giacomelli Nascimento, Carlos Eduardo da Rocha Santos, Renata Falchete do Prado, Marcia Carneiro Valera
OBJECTIVE: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied...
October 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29024901/impact-of-initial-medication-non-adherence-to-ssris-on-medical-visits-and-sick-leaves
#12
Ignacio Aznar-Lou, María Iglesias-González, Montserrat Gil-Girbau, Antoni Serrano-Blanco, Ana Fernández, María Teresa Peñarrubia-María, Ramón Sabés-Figuera, Ana Gabriela Murrugarra-Centurión, Marian March-Pujol, Mireia Bolívar-Prados, Maria Rubio-Valera
BACKGROUND: Initial medication non-adherence (IMNA) to antidepressants, which are commonly used to treat depression in primary care (PC), is around 6-12%. Although it is well known that post-initial non-adherence to antidepressants increases the cost of depression, the impact of IMNA on cost is unknown. The aim of this study is to assess the impact of IMNA to Selective Serotonin Reuptake Inhibitors (SSRI) on medical visits and sick leave in patients with depression treated in PC in Catalonia (Spain)...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28990927/frequency-dependent-mobilization-of-heterogeneous-pools-of-synaptic-vesicles-shapes-presynaptic-plasticity
#13
Frédéric Doussau, Hartmut Schmidt, Kevin Dorgans, Antoine M Valera, Bernard Poulain, Philippe Isope
The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity. However, the frequency-dependent mobilization of these sub-pools is poorly understood. Using slice recordings and modeling of synaptic activity at cerebellar granule cell to Purkinje cell synapses of mice, we describe two sub-pools in the RRP that can be differentially recruited upon ultrafast changes in the stimulation frequency. We show that at low-frequency stimulations, a first sub-pool is gradually silenced, leading to full blockage of synaptic transmission...
October 9, 2017: ELife
https://www.readbyqxmd.com/read/28985309/comparing-watchful-waiting-with-antidepressants-for-the-management-of-subclinical-depression-symptoms-to-mild-moderate-depression-in-primary-care-a-systematic-review
#14
Maria Iglesias-González, Ignacio Aznar-Lou, Montse Gil-Girbau, Patricia Moreno-Peral, M Teresa Peñarrubia-María, Maria Rubio-Valera, Antoni Serrano-Blanco
Background: The benefits of watchful waiting (WW) over antidepressants (ADs) for the treatment of depression in primary care (PC) are unclear. Objective: We aimed to systematically review the evidence supporting either WW or ADs for the treatment of subclinical depressive symptoms and mild-moderate depression in a PC setting. Methods: This systematic review was registered at PROSPERO (42016036345). Four electronic sources (EMBASE, PubMed, PsycINFO, Web of Knowledge) were systematically searched from inception to November 2016 for controlled trials comparing WW and ADs in PC following established guidelines...
November 16, 2017: Family Practice
https://www.readbyqxmd.com/read/28959228/effectiveness-of-the-what-s-up-intervention-to-reduce-stigma-and-psychometric-properties-of-the-youth-program-questionnaire-ypq-results-from-a-cluster-non-randomized-controlled-trial-conducted-in-catalan-high-schools
#15
Laura Andrés-Rodríguez, Adrián Pérez-Aranda, Albert Feliu-Soler, María Rubio-Valera, Ignacio Aznar-Lou, Antoni Serrano-Blanco, Miquel Juncosa, Anaïs Tosas, Albert Bernadàs, Juan V Luciano
Mental disorders are highly prevalent in the general population, and people who experience them are frequently stigmatized. Stigma has a very negative impact on social, academic/professional, and personal life. Considering the high rates of mental disorders among children and adolescents (13.4%) and how critical this age is in the formation of nuclear beliefs, many campaigns to combat stigma have been developed in the last decade, with mixed results. The OBERTAMENT initiative has produced various anti-stigma campaigns in Catalonia (Spain)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28948217/inward-h-pump-xenorhodopsin-mechanism-and-alternative-optogenetic-approach
#16
Vitaly Shevchenko, Thomas Mager, Kirill Kovalev, Vitaly Polovinkin, Alexey Alekseev, Josephine Juettner, Igor Chizhov, Christian Bamann, Charlotte Vavourakis, Rohit Ghai, Ivan Gushchin, Valentin Borshchevskiy, Andrey Rogachev, Igor Melnikov, Alexander Popov, Taras Balandin, Francisco Rodriguez-Valera, Dietmar J Manstein, Georg Bueldt, Ernst Bamberg, Valentin Gordeliy
Generation of an electrochemical proton gradient is the first step of cell bioenergetics. In prokaryotes, the gradient is created by outward membrane protein proton pumps. Inward plasma membrane native proton pumps are yet unknown. We describe comprehensive functional studies of the representatives of the yet noncharacterized xenorhodopsins from Nanohaloarchaea family of microbial rhodopsins. They are inward proton pumps as we demonstrate in model membrane systems, Escherichia coli cells, human embryonic kidney cells, neuroblastoma cells, and rat hippocampal neuronal cells...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28945750/genome-diversity-of-marine-phages-recovered-from-mediterranean-metagenomes-size-matters
#17
Mario López-Pérez, Jose M Haro-Moreno, Rafael Gonzalez-Serrano, Marcos Parras-Moltó, Francisco Rodriguez-Valera
Marine viruses play a critical role not only in the global geochemical cycles but also in the biology and evolution of their hosts. Despite their importance, viral diversity remains underexplored mostly due to sampling and cultivation challenges. Direct sequencing approaches such as viromics has provided new insights into the marine viral world. As a complementary approach, we analysed 24 microbial metagenomes (>0.2 μm size range) obtained from six sites in the Mediterranean Sea that vary by depth, season and filter used to retrieve the fraction...
September 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28913612/finger-tapping-and-pre-attentive-sensorimotor-timing-in-adults-with-adhd
#18
Michael J Hove, Nickolas Gravel, Rebecca M C Spencer, Eve M Valera
Sensorimotor timing deficits are considered central to attention-deficit/hyperactivity disorder (ADHD). However, the tasks establishing timing impairments often involve interconnected processes, including low-level sensorimotor timing and higher level executive processes such as attention. Thus, the source of timing deficits in ADHD remains unclear. Low-level sensorimotor timing can be isolated from higher level processes in a finger-tapping task that examines the motor response to unexpected shifts of metronome onsets...
December 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28877316/effectiveness-of-psychological-and-or-educational-interventions-in-the-prevention-of-anxiety-a-systematic-review-meta-analysis-and-meta-regression
#19
Patricia Moreno-Peral, Sonia Conejo-Cerón, Maria Rubio-Valera, Anna Fernández, Desirée Navas-Campaña, Alberto Rodríguez-Morejón, Emma Motrico, Alina Rigabert, Juan de Dios Luna, Carlos Martín-Pérez, Antonina Rodríguez-Bayón, María Isabel Ballesta-Rodríguez, Juan Vicente Luciano, Juan Ángel Bellón
Importance: To our knowledge, no systematic reviews or meta-analyses have been conducted to assess the effectiveness of preventive psychological and/or educational interventions for anxiety in varied populations. Objective: To evaluate the effectiveness of preventive psychological and/or educational interventions for anxiety in varied population types. Data Sources: A systematic review and meta-analysis was conducted based on literature searches of MEDLINE, PsycINFO, Web of Science, EMBASE, OpenGrey, Cochrane Central Register of Controlled Trials, and other sources from inception to March 7, 2017...
October 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28874562/stability-of-equidimensional-pseudo-single-domain-magnetite-over-billion-year-timescales
#20
Lesleis Nagy, Wyn Williams, Adrian R Muxworthy, Karl Fabian, Trevor P Almeida, Pádraig Ó Conbhuí, Valera P Shcherbakov
Interpretations of paleomagnetic observations assume that naturally occurring magnetic particles can retain their primary magnetic recording over billions of years. The ability to retain a magnetic recording is inferred from laboratory measurements, where heating causes demagnetization on the order of seconds. The theoretical basis for this inference comes from previous models that assume only the existence of small, uniformly magnetized particles, whereas the carriers of paleomagnetic signals in rocks are usually larger, nonuniformly magnetized particles, for which there is no empirically complete, thermally activated model...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
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