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JOURNAL ARTICLE
Santiago Candela-Cantó, José Hinojosa, Jordi Muchart, Cristina Jou, Laura Palau, Carlos Valera, Cecilia Flores, Andrea Palacio-Navarro, María Alejandra Climent, Anna Pascual, Adrià Gonzalez, Diego Culebras, Mariana Alamar, Victoria Becerra, Javier Aparicio, Jordi Rumià
Magnetic resonance imaging-guided laser interstitial thermal therapy (MRIgLITT) has been proven safe and effective for the treatment of focal epilepsy of different etiologies. It has also been used to disconnect brain tissue in more extensive or diffuse epilepsy, such as corpus callosotomy and hemispherotomy. In this study, we report a case of temporo-parieto-occipital disconnection (TPO) surgery performed using MRIgLITT assisted by a robotic arm for refractory epilepsy of the posterior quadrant. A highly realistic cadaver simulation was performed before the actual surgery...
April 17, 2024: World Neurosurgery
#2
Andrea Valera-Barrero, Jorge Madera-Fernández, Vicente González-Quintanilla, María José Sedano-Tous, Francisco Martínez Dubarbie
INTRODUCTION: Breast cancer in males is a very rare entity, and survival is mainly influenced by the stage at diagnosis. The lack of early detection tools in men results in a diagnostic delay of about 5-10 years and a higher percentage of metastatic disease at diagnosis. However, the characteristics of head metastases are not well defined. CASE REPORTS: We present two cases of male breast cancer with metastases affecting cranial nervous structures and we provide imaging and histologic data...
April 18, 2024: Oncology Research and Treatment
#3
JOURNAL ARTICLE
Eva Morales, María Teresa Prieto-Sánchez, Jaime Mendiola, Ana Cutillas-Tolín, Evdochia Adoamnei, Desirée Valera-Gran, Carmen Martínez-Graciá, Marina Santaella-Pascual, Clara Suárez-Martinez, Jesús Vioque, María Jesús Castaños, Eva Del Castillo, Luis García-Marcos
BACKGROUND & AIMS: Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels. METHODS: Data come from 325 mother-child pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015-2018)...
April 16, 2024: Clinical Nutrition
#4
Gemma Camiña-Conforto, Marta Ivars, Georgia Sarquella-Brugada, Carlos Valera-Dávila, Héctor Salvador, Carlota Rovira, Eulalia Baselga
Phacomatosis pigmentokeratotica (PPK) is a RASopathy characterized by the presence of a sebaceous nevus and a papular speckled lentiginous nevus. This case report highlights the associated extracutaneous comorbidities, including life-threatening arrhythmia, and introduces topical rapamycin as a potential therapeutic avenue for sebaceous nevus in PPK patients.
April 15, 2024: Pediatric Dermatology
#5
JOURNAL ARTICLE
Rafael Garcia, Maria Jiménez-Valera, Daniel Ruiz-Buck, Carlos Sanchez, Almudena Rojas, Malte Hendrik Schütz, Jose Rojas, Klaus- Peter Hunfeld
OBJECTIVES: Analyse alternative methods of intrathecal antibody detection by comparing chemiluminescent immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) techniques to determine if CLIA can replace ELISA in the diagnosis of CNS infections. METHODS: A panel of 280 paired samples-cerebrospinal fluid (CSF) and serum-with known antibody reactivities (Varicella, n = 60; Measles, n = 120) and negative samples (n = 100) were used to evaluate the performance of six serological test kits (Enzygnost, VirClia®, and Serion ELISA (Measles and Variella)...
April 13, 2024: European Journal of Clinical Microbiology & Infectious Diseases
#6
JOURNAL ARTICLE
Maria Ripollés-Lobo, Davinia I Perdomo-González, Mercedes Valera, María D Gómez
Limb-conformation defects significantly influence equine performance and welfare, necessitating thorough investigation for effective management. This study examines the prevalence and genetic parameters of 14 limb-conformation defects in Menorca Purebred horses using data from 1120 records (509 animals with an average age of 101.87 ± 1.74 months) collected between 2015 and 2023. Defects were evaluated using a three-class scale by three appraisers, and a Bayesian approach via Gibbs sampling was employed to estimate genetic parameters including gender, birth period, stud selection criteria, evaluation age and appraiser as fixed effects...
March 31, 2024: Animals: An Open Access Journal From MDPI
#7
JOURNAL ARTICLE
Juan Antonio Valera-Calero, Elena Sánchez-Jiménez, Gustavo Plaza-Manzano, César Fernández-de-Las-Peñas, Sandra Sánchez-Jorge, Marcos José Navarro-Santana
PURPOSE: Shear-wave elastography (SWE) provides quantitative and absolute metrics for analyzing the elasticity of soft tissues. Despite the anterior scalene muscle (AS) is a key structure in patients with neck pain and nerve compressive syndromes, the majority of SWE studies only included asymptomatic subjects. This study aimed to analyze the Young's modulus and shear wave speed test-retest reliability in a sample of patients with neck pain symptoms to characterize the AS stiffness. METHODS: A diagnostic accuracy study acquiring a set of ultrasound images at C7 level in 42 patients with mechanical neck pain by one experienced examiner...
April 10, 2024: Physica Medica: PM
#8
JOURNAL ARTICLE
Pamela Valera, Sarah Malarkey, Madelyn Owens, Noah Sinangil, Sanjana Bhakta, Tammy Chung
Mental health first aid (MHFA) training is a low-cost, evidence-based intervention that teaches trainees to recognize signs of mental distress. Thirty correctional officers (COs) were recruited to participate in a remote MHFA intervention study. The COs were divided into three MHFA training sessions, with no more than 10 COs per group. Data collection assessments included pretest and posttest surveys and a focus group meeting. Of the 30 eligible CO participants, 27 completed the study, including follow-up assessments...
April 11, 2024: Psychological Services
#9
JOURNAL ARTICLE
Victor Chavarria, Maria Rubio-Valera, Joan Doménech Abella, Luisa Higuera Baladón, Isabel Mateu, Jorge Arias de la Torre, Joan Costa Alvarós, Carlos Peña-Salazar, Alexandra L Dima, Antoni Serrano-Blanco
Objective: The SARS-CoV-2 pandemic and related lockdown periods generated an increase in the use of virtual care for mental health (MH). This study aimed to assess patient satisfaction with Telemental Health services (TMH) during first lockdown and factors related to their willingness to continue using this service. Methods: We conducted a cross-sectional survey of 364 MH outpatients from 9 centers in the Barcelona region (Spain), who received TMH between April 20 and May 22, 2020. We assessed sociodemographic and clinical characteristics, prior experience, and familiarity with technologies and satisfaction with TMH...
April 10, 2024: Telemedicine Journal and E-health
#10
JOURNAL ARTICLE
Vania Lo Presti, Angelo Meringa, Ester Dunnebach, Alice van Velzen, Aida Valera Moreira, Ronald W Stam, Rishi S Kotecha, Anja Krippner-Heidenreich, Olaf T Heidenreich, Maud Plantinga, Annelisa Cornel, Zsolt Sebestyen, Jurgen Kuball, Niek P van Til, S Nierkens
BACKGROUND: Hematopoietic cell transplantation (HCT) is an effective treatment for pediatric patients with high-risk, refractory, or relapsed acute myeloid leukemia (AML). However, a large proportion of transplanted patients eventually die due to relapse. To improve overall survival, we propose a combined strategy based on cord blood (CB)-HCT with the application of AML-specific T cell receptor (TCR)-engineered T cell therapy derived from the same CB graft. METHODS: We produced CB-CD8+ T cells expressing a recombinant TCR (rTCR) against Wilms tumor 1 (WT1) while lacking endogenous TCR (eTCR) expression to avoid mispairing and competition...
April 5, 2024: Journal for Immunotherapy of Cancer
#11
JOURNAL ARTICLE
Andrés E Valera-Montiel, Jaime López-Sánchez, Carlos R Diaz-Maag
BACKGROUND: ESG is a safe and effective technique in the obesity management, usually indicated in class I and II obesity. It is also an acceptable treatment in patients with class III obesity who have high surgical risk or refuse surgery. This procedure results in a significant weight loss and important improvement in metabolic comorbidities. Nevertheless, there are several procedure-related complications. Few cases of gastric perforation following ESG have been reported. We present a case of septic shock after ESG with preoperative diagnostic uncertainties...
May 2024: Obesity Surgery
#12
JOURNAL ARTICLE
TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
David Sebastián, Marc Beltrà, Andrea Irazoki, David Sala, Pilar Aparicio, Cecilia Aris, Esmaeil Alibakhshi, Maria Rubio-Valera, Manuel Palacín, Juan Castellanos, Luis Lores, Antonio Zorzano
Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed. Here we show that the autophagy regulator TP53INP2/TRP53INP2 is decreased during aging in mouse and human skeletal muscle...
March 28, 2024: Autophagy
#13
JOURNAL ARTICLE
Alcides Euzebio Tavares Xavier, Luciana Chain Veronez, Luís Fernando Peinado Nagano, Carolina Alves Pereira Correa, Mirela Baroni, Milena Silva Ramos, Rosane de Gomes de Paula Queiroz, Carlos Augusto Fernandes Molina, José Andres Yunes, Silvia Regina Brandalise, Sonir Antonio Rauber Antonini, Luiz Gonzaga Tone, Elvis Terci Valera, Carlos Alberto Scrideli
Pediatric adrenocortical tumors (ACTs) are rare, highly heterogeneous neoplasms with limited therapeutic options, making the investigation of new targets with potential therapeutic or prognostic purposes urgent. The PRKAB2 gene produces one of the subunits of the AMP-activated protein kinase (AMPK) complex and has been associated with cancer. However, little is known about the role AMPK plays in ACTs. We have evaluated how PRKAB2 is associated with clinical and biological characteristics in 63 pediatric patients with ACTs and conducted in vitro studies on the human NCI-H295R ACC cell line...
March 8, 2024: Cancers
#14
JOURNAL ARTICLE
Manuel Serrano Valera, Nuria Vela, Grasiela Piuvezam, Francisco Mateo-Ramírez, Isac Davidson Santiago Fernandes Pimenta, Isabel Martínez-Alcalá
There is currently a growing interest in the so-called emerging pollutants, such as pesticides, pharmaceuticals, personal hygiene care products, drugs, etc., whose presence in natural ecosystems is not necessarily recent, but the development in latest years of new and more sensitive methods of analysis has allowed their detection. They can be present in the natural environment, food, and many products of everyday origin, which suggests that human exposure to them is massive and universal. Therefore, the study of this type of substances is becoming one of the priority lines of research of the main agencies dedicated to the protection of public and environmental health, such as the World Health Organization (WHO), United States Environmental Protection Agency (USEPA) or European Union (EU)...
2024: PloS One
#15
REVIEW
Murtaza Kadhum, Karishma Khan, Khalifa Al-Ghanim, Valera Castanov, Caitlin Symonette, Muhammad Umair Javed
INTRODUCTION: Cadaveric fresh frozen cartilage provides an enticing alternative to traditional autologous cartilage grafts. This review provides a systematic analysis of existing literature on the use of fresh frozen rib for in rhinoplasties and focuses on clinical and aesthetic outcomes. METHODS: The methodology was designed and registered in the PROSPERO database (CRD42023447166). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline was used to perform this systematic review...
March 25, 2024: Aesthetic Plastic Surgery
#16
JOURNAL ARTICLE
María J Pumar-Méndez, Olga Lopez-Dicastillo, Naia Hernantes, Isabel Antón-Solanas, Edurne Zabaleta-Del-Olmo, Beatriz Rodríguez-Roca, Ana B Subirón-Valera, Dolors Juvinyà-Canal, Agurtzane Mujika
AIMS: This study outlines a protocol aimed at identifying and mapping health promotion practices in need of development from the perspectives of key sectors responsible for it at the local level and from an intersectoral perspective across four Spanish regions. DESIGN: A complementary multi-method study combining survey methods and qualitative interviews will be adopted. METHODS: Purposive snowball sampling will be employed to select potentially rich informants from city councils, primary care centres, primary and secondary schools, and public health and civil society organizations in 12 municipalities sensitive to local health...
March 25, 2024: Journal of Advanced Nursing
#17
JOURNAL ARTICLE
Carolina Acuna-Alonso, Renato Farias do Valle Junior, Mayte Maria Abreu Pires de Melo Silva, Teresa Cristina Tarlé Pissarra, Marília Carvalho de Melo, Carlos Alberto Valera, Luis Filipe Sanches Fernandes, Fernando António Leal Pacheco, Xana Álvarez
Understanding the origins of sediment transport in river systems is crucial for effective watershed management, especially after catastrophic events. This information is essential for the development of integrated strategies that guarantee water security in river basins. The present study aimed to investigate the rupture of the B1 tailings dam of the Córrego do Feijão mine, which drastically affected the Brumadinho region (Minas Gerais, Brazil). To address this issue, a confluence-based sediment fingerprinting approach was developed through the SedSAT model...
March 22, 2024: Journal of Environmental Management
#18
JOURNAL ARTICLE
Juliana Ribeiro-Constante, Alba Tristán-Noguero, Fernando Francisco Martínez Calvo, Salvador Ibañez-Mico, José Luis Peña Segura, José Miguel Ramos-Fernández, María Del Carmen Moyano Chicano, Rafael Camino León, Víctor Soto Insuga, Elena González Alguacil, Carlos Valera Dávila, Alberto Fernández-Jaén, Laura Plans, Ana Camacho, Nuria Visa-Reñé, María Del Pilar Martin-Tamayo Blázquez, Fernando Paredes-Carmona, Itxaso Marti-Carrera, Aránzazu Hernández-Fabián, Meritxell Tomas Davi, Merce Casadesus Sanchez, Laura Cuesta Herraiz, Patricia Fuentes Pita, Teresa Bermejo Gonzalez, Mar O'Callaghan, Federico Felipe Iglesias Santa Polonia, María Rosario Cazorla, María Teresa Ferrando Lucas, Antonio González-Meneses, Júlia Sala-Coromina, Alfons Macaya, Amaia Lasa-Aranzasti, Anna Ma Cueto-González, Francisca Valera Párraga, Jaume Campistol Plana, Mercedes Serrano, Xenia Alonso, Diego Del Castillo-Berges, Marc Schwartz-Palleja, Sofía Illescas, Alia Ramírez Camacho, Oscar Sans Capdevila, Angeles García-Cazorla, Àlex Bayés, Itziar Alonso-Colmenero
SYNGAP1 haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies accompanied by a spectrum of neurodevelopmental symptoms. Concerning interictal epileptiform discharges (IEDs) in electroencephalograms (EEG), potential biomarkers have been postulated, including changes in background activity, fixation-off sensitivity (FOS) or eye closure sensitivity (ECS). In this study we clinically evaluate a new cohort of 36 SYNGAP1-DEE individuals. Standardized questionnaires were employed to collect clinical, electroencephalographic and genetic data...
2024: Frontiers in Cell and Developmental Biology
#19
JOURNAL ARTICLE
Daniel Albert-Lucena, Marcos José Navarro-Santana, María José Días-ArribasPT, Juan Antonio Valera-Calero, César Fernández-de-Las-Peñas, Gustavo Plaza-Manzano
OBJECTIVE: Clinical practice guidelines recommend the radial nerve mechanosensitivity evaluation in patients with lateral epicondylalgia. Despite different positions and sequences having been described, no research analyzed how each variation triggers symptoms associated with lateral epicondylalgia. The aim of this study was to explore the effects of different positions and sequences in the upper limb neural tension test 2b (ULNT2b) in symptom responses in patients with lateral epicondylalgia...
March 19, 2024: Physical Therapy
#20
JOURNAL ARTICLE
Marina Fuente-Moreno, Alexandra L Dima, Maria Rubio-Valera, Luisa Baladon, Victor Chavarria, Salvatore Fabrizio Contaldo, Carlos Peña-Salazar, Vicky Serra-Sutton, Patricia Hermida-González, Jorge Peláez de Loño, Maria Eugènia Rey-Abella, Ignacio Aznar-Lou, Antoni Serrano-Blanco
AIMS: This study aimed to assess the frequency of dosing inconsistencies in prescription data and the effect of four dosing assumption strategies on adherence estimates for antipsychotic treatment. METHODS: A retrospective cohort, which linked prescription and dispensing data of adult patients with ≥1 antipsychotic prescription between 2015-2016 and followed up until 2019, in Catalonia (Spain). Four strategies were proposed for selecting the recommended dosing in overlapping prescription periods for the same patient and antipsychotic drug: (i) the minimum dosing prescribed; (ii) the dose corresponding to the latest prescription issued; (iii) the highest dosing prescribed; and (iv) all doses included in the overlapped period...
March 18, 2024: British Journal of Clinical Pharmacology
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