keyword
https://read.qxmd.com/read/38447697/examination-of-monosodium-urate-crystal-depletion-and-bone-erosion-remodeling-during-pegloticase-treatment-in-patients-with-uncontrolled-gout-exploratory-dual-energy-computed-tomography-findings-from-mirror-rct
#21
JOURNAL ARTICLE
Nicola Dalbeth, John Botson, Kenneth Saag, Ada Kumar, Lissa Padnick-Silver, Brian LaMoreaux, Fabio Becce
OBJECTIVE: Monosodium-urate (MSU) crystal deposits can be visualized and quantified with dual-energy CT (DECT). Pegloticase lowers serum urate (SU) in uncontrolled gout patients, with methotrexate (MTX) co-therapy recommended to increase SU-lowering response rate and decrease infusion reaction risk. The literature on serial DECT-imaging during pegloticase+MTX co-therapy is sparse, with only 2 prior cases of rapid MSU deposition depletion with subsequent bone-erosion remodeling reported from a small open-label trial...
March 4, 2024: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/38443725/a-short-update-on-the-use-of-monoclonal-antibodies-in-covid-19
#22
JOURNAL ARTICLE
Antonio Vitiello, Michela Sabbatucci, Annarita Ponzo, Antonio Salzano, Andrea Zovi
Monoclonal antibodies in the prophylaxis and treatment of COVID-19 have been crucial in reducing severe infections when vaccines were unavailable. However, as the virus and its variants have changed over time, the effectiveness of monoclonal antibodies has been questioned. This technical note highlights the need to assess the antiviral activity of these antibodies against new variants and adapt treatment strategies accordingly. On the one hand, in vitro studies have suggested reduced susceptibility of the latest variants to monoclonal antibodies, whereas clinical data still show benefits in reducing severe illness and mortality, indicating that laboratory results do not always mirror real-world outcomes...
March 5, 2024: AAPS Journal
https://read.qxmd.com/read/38437102/virtual-reality-self-co-embodiment-an-alternative-to-mirror-therapy-for-post-stroke-upper-limb-rehabilitation
#23
JOURNAL ARTICLE
Rodrigo Cerecero Curiel, Takuto Nakamura, Hideaki Kuzuoka, Takafumi Kanaya, Cosima Prahm, Keigo Matsumoto
We present Virtual Reality Self Co-embodiment, a new method for post-stroke upper limb rehabilitation. It is inspired by mirror therapy, where the patient's healthy arm is involved in recovering the affected arm's motion. By tracking the user's head, wrists, and fingers' positions, our new approach allows the handicapped arm to control a digital avatar in order to pursue a reaching task. We apply the concept of virtual co-embodiment to use the information from the unaffected arm and complete the affected limb's impaired motion, which is our added unique feature...
March 4, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38436165/nailfold-capillaroscopy-abnormalities-and-pulmonary-hypertension-in-mixed-connective-tissue-disease-and-systemic-sclerosis-patients
#24
JOURNAL ARTICLE
A Munteanu, N R Kundnani, A Caraba
OBJECTIVE: Pulmonary arterial hypertension (PAH) represents an important vascular complication of mixed connective tissue disease (MCTD) and systemic sclerosis (SSc). Microvascular involvement in these diseases can be investigated by means of nailfold capillaroscopy (NFC). Microvascular involvement detected in the nailfold bed is the mirror of the microvascular damage occurring in the entire body, further indicating the involvement of the target organs. The aim of this study was to evaluate the microvascular involvement in MCTD patients with or without PAH, compared to that found in SSc patients with or without PAH...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38430355/assessment-of-barriers-to-referral-and-appointment-wait-times-for-the-evaluation-of-spinal-muscular-atrophy-sma-findings-from-a-web-based-physician-survey
#25
JOURNAL ARTICLE
Mary A Curry, Rosángel E Cruz, Lisa T Belter, Mary K Schroth, Jill Jarecki
BACKGROUND: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. Clinical trial data suggest early diagnosis and treatment are critical. The purpose of this study was to evaluate neurology appointment wait times for newborn screening identified infants, pediatric cases mirroring SMA symptomatology, and cases in which SMA is suspected by the referring physician. Approaches for triaging and expediting referrals in the US were also explored...
March 2, 2024: Neurology and Therapy
https://read.qxmd.com/read/38430148/effect-of-mvf-combined-with-fes-on-limb-function-recovery-and-fine-function-rehabilitation-of-hemiplegic-patients-after-aci
#26
JOURNAL ARTICLE
Peng Li, Hui Xin, Xinjie Zhang, Xiuli Li, Lihui Dou, Guiling Wang, Yan Li
BACKGROUND: This study assesses the efficacy of mirror visual feedback (MVF) combined with functional electrical stimulation (FES) in rehabilitating limb function and fine motor skills in hemiplegic patients after acute cerebral infarction (ACI). Given the limited research in this area, this study aims to provide insights into innovative rehabilitation techniques. METHODS: A randomized controlled trial was conducted on 106 post-ACI hemiplegic patients, split into two groups of 53 each...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38409101/the-rehabilitation-workforce-in-brazil
#27
JOURNAL ARTICLE
Taciana Rocha Dos Santos Sixel, Debora Bernardo, Arthur de Almeida Medeiros, Aylene Bousquat, Paulo Henrique Dos Santos Mota, Ana Carolina Basso Schmitt
BACKGROUND: The surge in individuals facing functional impairments has heightened the demand for rehabilitation services. Understanding the distribution of the rehabilitation workforce is pivotal for effective health system planning to address the population's health needs. OBJECTIVE: To investigate the spatial and temporal dispersion of physical therapists, speech therapists, psychologists and occupational therapists across various tiers of care within Brazil's Unified Health System and its regions...
February 26, 2024: Archives of Public Health, Archives Belges de Santé Publique
https://read.qxmd.com/read/38408845/skewed-x-chromosome-inactivation-drives-the-proportion-of-dnaaf6-defective-airway-motile-cilia-and-variable-expressivity-in-primary-ciliary-dyskinesia
#28
JOURNAL ARTICLE
Lucie Thomas, Laurence Cuisset, Jean-Francois Papon, Aline Tamalet, Isabelle Pin, Rola Abou Taam, Catherine Faucon, Guy Montantin, Sylvie Tissier, Philippe Duquesnoy, Florence Dastot-Le Moal, Bruno Copin, Nathalie Carion, Bruno Louis, Sandra Chantot-Bastaraud, Jean-Pierre Siffroi, Rana Mitri, André Coste, Estelle Escudier, Guillaume Thouvenin, Serge Amselem, Marie Legendre
BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare airway disorder caused by defective motile cilia. Only male patients have been reported with pathogenic mutations in X-linked DNAAF6 , which result in the absence of ciliary dynein arms, whereas their heterozygous mothers are supposedly healthy. Our objective was to assess the possible clinical and ciliary consequences of X-chromosome inactivation (XCI) in these mothers. METHODS: XCI patterns of six mothers of male patients with DNAAF6 -related PCD were determined by DNA-methylation studies and compared with their clinical phenotype (6/6 mothers), as well as their ciliary phenotype (4/6 mothers), as assessed by immunofluorescence and high-speed videomicroscopy analyses...
February 26, 2024: Journal of Medical Genetics
https://read.qxmd.com/read/38408745/quantitative-eeg-for-the-monitoring-of-walking-recovery-in-chronic-stroke-patients-receiving-action-observation-training
#29
JOURNAL ARTICLE
Fatemeh Shamsi, Hadi Aligholi, Mohammad Taghi Karimi, Afshin Borhani-Haghighi, Mohammad Nami
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO) or sham observation (SO) groups. Both groups received 12 sessions of intervention. Each session composed of 12 min of observational training, which depicted exercises for the experimental group but nature pictures for the sham group and 40 min of occupational therapy, which was the same for the both groups...
February 26, 2024: Journal of Motor Behavior
https://read.qxmd.com/read/38408073/nutraceuticals-known-to-promote-hair-growth-do-not-interfere-with-the-inhibitory-action-of-tamoxifen-in-mcf7-t47d-and-bt483-breast-cancer-cell-lines
#30
JOURNAL ARTICLE
Richard Baker, Giorgio Dell'Acqua, Aleksander Richards, M Julie Thornton
BACKGROUND: Hair loss/thinning is a common side effect of tamoxifen in estrogen receptor (ER) positive breast cancer therapy. Some nutraceuticals known to promote hair growth are avoided during breast cancer therapy for fear of phytoestrogenic activity. However, not all botanical ingredients have similarities to estrogens, and in fact, no information exists as to the true interaction of these ingredients with tamoxifen. Therefore, this study sought to ascertain the effect of nutraceuticals (+/- estrogen/tamoxifen), on proliferation of breast cancer cells and the relative expression of ERα/β...
2024: PloS One
https://read.qxmd.com/read/38398434/complex-regional-pain-syndrome-after-distal-radius-fracture-case-report-and-mini-literature-review
#31
Michał Świta, Paweł Szymonek, Konrad Talarek, Agnieszka Tomczyk-Warunek, Karolina Turżańska, Agnieszka Posturzyńska, Anna Winiarska-Mieczan
This study explores the impact of the complex regional pain syndrome (CRPS) on the lives and mobility of patients, with a particular focus on its emergence as a late complication of distal radius fractures (DRFs), a common occurrence, especially among an aging population. The absence of a standardized treatment for the CRPS and the challenge of predicting its occurrence make it a complex medical issue. This research aims to shed light on the effects of treating the CRPS through a case study involving a 75-year-old woman with untreated osteoporosis who experienced a Colles fracture after a fall...
February 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38393824/the-effects-in-vitro-of-photobiomodulation-over-fibroblasts-and-extracellular-matrix
#32
JOURNAL ARTICLE
Marcos Fernando Xisto Braga Cavalcanti, Roseli Alves Cabette, Angelina Cirelli Moraes, Francesca Diomede, Oriana Trubiani, Durvanei Augusto Maria
Objective: The objective of this study is to evaluate the potential effects of photobiomodulation (PBM) on cell proliferation and extracellular matrix production of human fibroblasts (FN1) cultured in 2D. Background: Patients with healing difficulties suffer injuries that take time to recover. In addition, aging can be seen in our faces daily when we look in the mirror; in both situations, collagen production is reduced. Fibroblasts act in the beginning and at the end of the inflammation phase, signaling to immune agents, and platelets, and producing collagen, coordinating repair...
February 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38382136/distinct-patterns-of-metabolic-motor-cortex-activity-for-phantom-and-residual-limb-pain-in-people-with-amputations-a-functional-near-infrared-spectroscopy-study
#33
JOURNAL ARTICLE
Marcel Simis, Lucas Murrins Marques, Sara Pinto Barbosa, André Tadeu Sugawara, João Ricardo Sato, Kevin Pacheco-Barrios, Linamara Rizzo Battistella, Felipe Fregni
BACKGROUND: Phantom pain limb (PLP) has gained more attention due to the large number of people with amputations around the world and growing knowledge of the pain process, although its mechanisms are not completely understood. OBJECTIVES: The aim of this study was to understand, in patients with amputations, the association between PLP and residual limb pain (RLP), and the brain metabolic response in cortical motor circuits, using functional near-infrared spectroscopy (fNIRS)...
February 20, 2024: Clinical Neurophysiology
https://read.qxmd.com/read/38378783/s100a8-a9-predicts-response-to-pim-kinase-and-pd-1-pd-l1-inhibition-in-triple-negative-breast-cancer-mouse-models
#34
JOURNAL ARTICLE
Lauren R Begg, Adrienne M Orriols, Markella Zannikou, Chen Yeh, Pranathi Vadlamani, Deepak Kanojia, Rosemary Bolin, Sara F Dunne, Sanjeev Balakrishnan, Roman Camarda, Diane Roth, Nicolette A Zielinski-Mozny, Christina Yau, Athanassios Vassilopoulos, Tzu-Hsuan Huang, Kwang-Youn A Kim, Dai Horiuchi
BACKGROUND: Understanding why some triple-negative breast cancer (TNBC) patients respond poorly to existing therapies while others respond well remains a challenge. This study aims to understand the potential underlying mechanisms distinguishing early-stage TNBC tumors that respond to clinical intervention from non-responders, as well as to identify clinically viable therapeutic strategies, specifically for TNBC patients who may not benefit from existing therapies. METHODS: We conducted retrospective bioinformatics analysis of historical gene expression datasets to identify a group of genes whose expression levels in early-stage tumors predict poor clinical outcomes in TNBC...
February 20, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38360820/validation-of-portable-in-clinic-video-based-gait-analysis-for-prosthesis-users
#35
JOURNAL ARTICLE
Anthony Cimorelli, Ankit Patel, Tasos Karakostas, R James Cotton
Despite the common focus of gait in rehabilitation, there are few tools that allow quantitatively characterizing gait in the clinic. We recently described an algorithm, trained on a large dataset from our clinical gait analysis laboratory, which produces accurate cycle-by-cycle estimates of spatiotemporal gait parameters including step timing and walking velocity. Here, we demonstrate this system generalizes well to clinical care with a validation study on prosthetic users seen in therapy and outpatient clinics...
February 15, 2024: Scientific Reports
https://read.qxmd.com/read/38355716/modeling-early-pathophysiological-phenotypes-of-diabetic-retinopathy-in-a-human-inner-blood-retinal-barrier-on-a-chip
#36
JOURNAL ARTICLE
Thomas L Maurissen, Alena J Spielmann, Gabriella Schellenberg, Marc Bickle, Jose Ricardo Vieira, Si Ying Lai, Georgios Pavlou, Sascha Fauser, Peter D Westenskow, Roger D Kamm, Héloïse Ragelle
Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known, disease mechanisms including basement membrane thickening, pericyte dropout and capillary damage remain poorly understood and interventions to repair diseased iBRB microvascular networks have not been developed. In addition, current approaches using animal models and in vitro systems lack translatability and predictivity to finding new target pathways...
February 14, 2024: Nature Communications
https://read.qxmd.com/read/38352631/robotic-mirror-therapy-for-stroke-rehabilitation-through-virtual-activities-of-daily-living
#37
JOURNAL ARTICLE
Harris Nisar, Srikar Annamraju, Shankar A Deka, Anne Horowitz, Dušan M Stipanović
Mirror therapy is a standard technique of rehabilitation for recovering motor and vision abilities of stroke patients, especially in the case of asymmetric limb function. To enhance traditional mirror therapy, robotic mirror therapy (RMT) has been proposed over the past decade, allowing for assisted bimanual coordination of paretic (affected) and contralateral (healthy) limbs. However, state-of-the-art RMT platforms predominantly target mirrored motions of trajectories, largely limited to 2-D motions. In this paper, an RMT platform is proposed, which can facilitate the patient to practice virtual activities of daily living (ADL) and thus enhance their independence...
December 2024: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/38347643/oncogenic-alterations-in-advanced-nsclc-a-molecular-super-highway
#38
REVIEW
Alex Friedlaender, Maurice Perol, Giuseppe Luigi Banna, Kaushal Parikh, Alfredo Addeo
Lung cancer ranks among the most common cancers world-wide and is the first cancer-related cause of death. The classification of lung cancer has evolved tremendously over the past two decades. Today, non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma, comprises a multitude of molecular oncogenic subsets that change both the prognosis and management of disease.Since the first targeted oncogenic alteration identified in 2004, with the epidermal growth factor receptor (EGFR), there has been unprecedented progress in identifying and targeting new molecular alterations...
February 12, 2024: Biomarker Research
https://read.qxmd.com/read/38346365/effects-of-mirror-neuron-activation-therapies-on-functionality-in-older-adults-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Sara Mollà-Casanova, Álvaro Page, Juan López-Pascual, Marta Inglés, Núria Sempere-Rubio, Marta Aguilar-Rodríguez, Elena Muñoz-Gómez, Pilar Serra-Añó
PURPOSE: To identify the effects of mirror neuron activation (MNAT) combined or not with physical exercise (PE) in healthy older adults, on functionality, balance, gait velocity and risk of falls. METHODS: A systematic electronic search was performed in PubMed/MEDLINE, Cochrane, and Embase databases. RESULTS: Thirteen randomized controlled trials were included in the qualitative analysis, and eleven in the quantitative analysis. All studies showed fair to high quality and the most frequent high-risk bias was "Blinding of participants and personnel"...
February 10, 2024: Geriatric Nursing
https://read.qxmd.com/read/38345950/stiffness-tunable-substrate-fabrication-by-dmdbased-optical-projection-lithography-for-cancer-cell-invasion-studies
#40
JOURNAL ARTICLE
Quan Gan, Zhixing Ge, Xiaoduo Wang, Songchen Dai, Na Li, Jingang Wang, Lianqing Liu, Haibo Yu
Cancer cell invasion is a critical cause of fatality in cancer patients. Physiologically relevant tumor models play a key role in revealing the mechanisms underlying the invasive behavior of cancer cells. However, most existing models only consider interactions between cells and extracellular matrix (ECM) components while neglecting the role of matrix stiffness in tumor invasion. Here, we propose an effective approach that can construct stiffness-tunable substrates using digital mirror device (DMD)-based optical projection lithography to explore the invasion behavior of cancer cells...
February 12, 2024: IEEE Transactions on Bio-medical Engineering
keyword
keyword
29017
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.