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https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#1
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29644880/effects-of-mirror-therapy-on-walking-ability-balance-and-lower-limb-motor-recovery-after-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Yi Li, Qingchuan Wei, Wei Gou, Chengqi He
OBJECTIVE: To investigate the effects of mirror therapy on walking ability, balance and lower limb motor recovery in patients with stroke. METHOD: MEDLINE, EMBASE, Web of Science, CENTRAL, PEDro Database, CNKI, VIP, Wan Fang, ClinicalTrials.gov, Current controlled trials and Open Grey were searched for randomized controlled trials that investigated the effects of mirror therapy on lower limb function through January 2018. The primary outcomes included were walking speed, mobility and balance function...
April 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29643578/effect-of-mirror-therapy-and-electrical-stimulation-on-upper-extremity-function-in-stroke-with-hemiplegic-patient-a-pilot-study
#3
Young-Rim Paik, Jeong-Hoon Lee, Doo-Ho Lee, Hee-Su Park, Dong-Hwan Oh
[Purpose] This study investigated the effects of mirror therapy and neuromuscular electrical stimulation on upper extremity function in stroke patients. [Subjects and Methods] This study recruited 8 stroke patients. All patients were treated with mirror therapy and neuromuscular electrical stimulation five times per week for 4 weeks. Upper limb function evaluation was performed using upper extremity part of fugl meyer assessment. [Results] Before and after intervention, fugl meyer assessment showed significant improvement...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29625560/resolution-of-maternal-mirror-syndrome-after-succesful-fetal-intrauterine-therapy-a-case-series
#4
Angel Chimenea, Lutgardo García-Díaz, Ana María Calderón, María Moreno-De Las Heras, Guillermo Antiñolo
BACKGROUND: Mirror syndrome (MS) is a rare obstetric condition usually defined as the development of maternal edema in association with fetal hydrops. The pathogenesis of MS remains unclear and may be misdiagnosed as pre-eclampsia. CASE PRESENTATION: We report a case series of MS in which fetal therapy (intrauterine blood transfusion and pleuroamniotic shunt) resulted in fetal as well as maternal favourable course with complete resolution of the condition in both mother and fetus...
April 6, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29623562/decline-in-buprenorphine-naloxone-prescriptions-in-a-state-medicaid-population-following-formulary-conversion-from-suboxone-to-bunavail
#5
Richard Soper, Sireesh Appajosyula, Christina Deximo
INTRODUCTION: A large, statewide, fee-for-service Medicaid plan recently (October 2015) executed a complete switch from sublingual buprenorphine-naloxone [(SLBN), Suboxone® ] to buccal buprenorphine-naloxone [(BBN), Bunavail® ] on its preferred drug formulary. This complete formulary switch provided an opportunity to assess dynamic changes in prescribing patterns, patient/physician acceptance, and indices of potential misuse/diversion. METHODS: For the period January 1, 2015 through December 31, 2016, two datasets were analyzed: prescriptions and associated costs for buprenorphine-naloxone (BN) products and urine toxicology test results for patients in the Medicaid plan...
April 6, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29616149/immersive-virtual-reality-therapy-with-myoelectric-control-for-treatment-resistant-phantom-limb-pain-case-report
#6
Brian Chau, Ivan Phelan, Phillip Ta, Sarah Humbert, Justin Hata, Duc Tran
Objective: Phantom limb pain is a condition frequently experienced after amputation. One treatment for phantom limb pain is traditional mirror therapy, yet some patients do not respond to this intervention, and immersive virtual reality mirror therapy offers some potential advantages. We report the case of a patient with severe phantom limb pain following an upper limb amputation and successful treatment with therapy in a custom virtual reality environment. Methods: An interactive 3-D kitchen environment was developed based on the principles of mirror therapy to allow for control of virtual hands while wearing a motion-tracked, head-mounted virtual reality display...
July 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29615666/insensitivity-to-atorvastatin-is-associated-with-increased-accumulation-of-intracellular-lipid-droplets-and-fatty-acid-metabolism-in-breast-cancer-cells
#7
Barbara Lettiero, Maria Inasu, Siker Kimbung, Signe Borgquist
Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in regulation of lipid metabolism and abundance of neutral lipid-containing cytoplasmic lipid droplets (LDs) in BC cells displaying different sensitivity to atorvastatin. Following atorvastatin treatment, accumulated LD levels inversely mirrored the marginal anti-proliferative effects in a dose and time-dependent manner in the less-sensitive BC cells...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611142/combined-transcranial-direct-current-stimulation-and-virtual-reality-based-paradigm-for-upper-limb-rehabilitation-in-individuals-with-restricted-movements-a-feasibility-study-with-a-chronic-stroke-survivor-with-severe-hemiparesis
#8
María Antonia Fuentes, Adrián Borrego, Jorge Latorre, Carolina Colomer, Mariano Alcañiz, María José Sánchez-Ledesma, Enrique Noé, Roberto Llorens
Impairments of the upper limb function are a major cause of disability and rehabilitation. Most of the available therapeutic options are based on active exercises and on motor and attentional inclusion of the affected arm in task oriented movements. However, active movements may not be possible after severe impairment of the upper limbs. Different techniques, such as mirror therapy, motor imagery, and non-invasive brain stimulation have been shown to elicit cortical activity in absence of movements, which could be used to preserve the available neural circuits and promote motor learning...
April 2, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29605215/direct-and-indirect-effects-of-growth-hormone-deficiency-ghd-on-lung-function-in-children-a-mediation-analysis
#9
Giovanna Cilluffo, Giuliana Ferrante, Salvatore Fasola, Alessandro Ciresi, Irene Cardillo, Giancarlo Tancredi, Giovanni Viegi, Carla Giordano, Nicola Scichilone, Stefania La Grutta
BACKGROUND: Studies on pulmonary function tests (PFTs) in Growth Hormone Deficiency (GHD) children are lacking. The aims of this study were: (i) to investigate PFTs in GHD pre-pubertal children with respect to Controls, before starting Growth Hormone Therapy (GHT) (T0); (ii) to evaluate changes of PFTs in GHD vs Controls, after 1-year GHT (T1). For both aims the mediation analysis (MA) was applied to evaluate the extent to which the relationship between GHD and PFTs could be ascribed to a height-mediated (indirect) or a GH direct effect...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29601451/serum-levels-of-syndecan-1-in-patients-with-kawasaki-disease
#10
Li Luo, Siqi Feng, Yao Wu, Ya Su, Fengchuan Jing, Qijian Yi
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis with coronary artery lesions (CALs) being the major concern. Syndecan-1 (SDC-1) is a major core protein expressed on the glycocalyx of endothelial cells. Shed SDC-1 in serum is regarded as a biomarker for endothelial activation or damage. METHODS: In this study, we aimed to determine the serum levels of SDC-1 and evaluate the relationship between serum levels of SDC-1 and the CALs in the acute phase of KD...
March 29, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29589777/mirror-therapy-and-treadmill-training-for-a-patient-with-chronic-stroke-a-case-report
#11
Patrick Broderick, Frances Horgan, Catherine Blake, Paula Hickey, Joanne O'Reilly, Monika Ehrensberger, Daniel Simpson, David Roberts, Kenneth Monaghan
INTRODUCTION: A large proportion of patients with chronic stroke have permanent lower limb functional disability leading to reduced levels of independent mobility. Individually, both mirror therapy and treadmill training have been shown to improve aspects of lower limb functioning in patients with stroke. This case report examined whether a new combination of both interventions would lead to improvements in lower limb functional disability for a patient with chronic stroke. CASE DESCRIPTION: The participant was a 50-year-old female who had a left middle cerebral artery infarction (47 months' post stroke)...
March 28, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29589518/effects-of-different-frequencies-of-repetitive-transcranial-magnetic-stimulation-in-stroke-patients-with-non-fluent-aphasia-a-randomized-sham-controlled-study
#12
Xue-Yan Hu, Tong Zhang, Gary B Rajah, Christopher Stone, Li-Xu Liu, Jing-Jie He, Lei Shan, Ling-Yu Yang, Ping Liu, Fei Gao, Yu-Qi Yang, Xiao-Li Wu, Chang-Qing Ye, Yu-Dong Chen
OBJECTIVE: The purpose of this study was to compare the efficacy of repetitive transcranial magnetic stimulation (rTMS) applied at different frequencies to the contra-lesional hemisphere to optimize the treatment of post-stroke non-fluent aphasia. METHOD: Patients with post-stroke non-fluent aphasia were divided randomly into four groups: a high-frequency rTMS (HF-rTMS) group (10 Hz), a low-frequency rTMS (LF-rTMS) group (1 Hz), a sham stimulation group, and a control group...
March 28, 2018: Neurological Research
https://www.readbyqxmd.com/read/29563297/central-nervous-system-inflammation-and-infection-during-early-non-accelerated-simian-human-immunodeficiency-virus-infection-in-rhesus-macaques
#13
Denise C Hsu, Piyanate Sunyakumthorn, Matthew Wegner, Alexandra Schuetz, Decha Silsorn, Jacob D Estes, Claire Deleage, Khamis Tomusange, Samir K Lakhashe, Ruth M Ruprecht, Eric Lombardini, Rawiwan Im-Erbsin, Yanin Kuncharin, Yuwadee Phuang-Ngern, Dutsadee Inthawong, Weerawan Chuenarom, Robin Burke, Merlin L Robb, Lishomwa C Ndhlovu, Jintanat Ananworanich, Victor Valcour, Robert J O'Connell, Serena Spudich, Nelson L Michael, Sandhya Vasan
Studies utilizing highly pathogenic simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) have largely focused on the immunopathology of the central nervous system (CNS) during end-stage neuro AIDS and SIV encephalitis. However, this may not model pathophysiology in earlier stages of infection. In this non-accelerated SHIV model, plasma SHIV RNA levels and peripheral blood and colonic CD4 T+ cell counts mirrored early HIV infection in humans. At 12 weeks post infection, cerebrospinal fluid (CSF) detection of SHIV RNA and elevations in IP-10 and MCP-1 reflected a discrete neurovirologic process...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29563072/d-serine-is-a-potential-biomarker-for-clinical-response-in-treatment-of-post-traumatic-stress-disorder-using-r-s-ketamine-infusion-and-timber-psychotherapy-a-pilot-study
#14
Basant Pradhan, Ludmil Mitrev, Ruin Moaddell, Irving W Wainer
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7 days. In one of our studies, the mean duration of response was increased to 33 days when Ket administration was combined with a mindfulness-based cognitive therapy, Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER)...
March 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29559178/effectiveness-of-complex-regional-pain-syndrome-treatment-a-systematic-review
#15
REVIEW
Andrzej Żyluk, Piotr Puchalski
Complex regional pain syndrome (CRPS) is a descriptive term for a complex of symptoms and signs typically occurring following trauma of the extremity. Typical symptomatology includes severe pain, swelling, vasomotor instability and functional impairment of the affected limb. At present there is no one, effective method of treatment of the condition. A large number of treatments have been investigated but major multicentre randomized controlled trials are lacking. This study presents the results of a systematic review of the evidence on effectiveness of treatment methods in CRPS...
March 12, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29558044/efficacy-and-safety-of-golimumab-as-add-on-therapy-to-standard-disease-modifying-antirheumatic-drugs-results-of-the-go-more-study-in-the-polish-population
#16
Sławomir Jeka, Bogdan Batko, Mariusz Korkosz, Maria Majdan, Brygida Kwiatkowska, Iwona Dankiewicz-Fares, Jerzy M Sobiecki, Włodzimierz Samborski
BACKGROUND: The GO-MORE study was an open-label, multinational, prospective study that investigated the efficacy and safety of adding golimumab to synthetic disease-modifying antirheumatic drugs (sDMARDs) in patients with active rheumatoid arthritis (RA). OBJECTIVES: The aim of this study was to assess the efficacy and safety of golimumab add-on therapy in the Polish subpopulation of the GO-MORE study. MATERIAL AND METHODS: Patients were administered 50 mg subcutaneous doses of golimumab once a month for 6 months, while continuing therapy with sDMARDs and/or glucocorticoids (GCS)...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29545680/effect-of-mirror-use-on-lower-extremity-muscle-strength-of-patients-with-chronic-stroke
#17
Myoung-Kwon Kim, Yu-Won Choe, Young-Jun Shin, Cheng Peng, Eun-Hong Choi
[Purpose] This study examines the effect on muscle strength of lower extremity muscle strength exercise while using a mirror on the non-paretic side in patients with chronic stroke. [Subjects and Methods] Subjects were randomly assigned to a non-mirror lower extremity exercise group (n=10), a mirror lower extremity exercise group (n=10), or a mirror lower extremity muscle strength exercise group (n=10). Subjects were asked to do the exercise assigned to their group (5 sets 30 times a day, 5 times weekly for 4 weeks) with general physical therapy in the hospital...
February 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29543180/the-impact-of-avatar-personalization-and-immersion-on-virtual-body-ownership-presence-and-emotional-response
#18
Thomas Waltemate, Dominik Gall, Daniel Roth, Mario Botsch, Marc Erich Latoschik
This article reports the impact of the degree of personalization and individualization of users' avatars as well as the impact of the degree of immersion on typical psychophysical factors in embodied Virtual Environments. We investigated if and how virtual body ownership (including agency), presence, and emotional response are influenced depending on the specific look of users' avatars, which varied between (1) a generic hand-modeled version, (2) a generic scanned version, and (3) an individualized scanned version...
April 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29524253/5-alpha-reductase-inhibitor-treatment-for-frontal-fibrosing-alopecia-an-evidence-based-treatment-update
#19
Aizuri Murad, Wilma Bergfeld
BACKGROUND: Treatment for frontal fibrosing alopecia (FFA) is challenging and its treatment regimen often mirrors other lymphocytic-predominant cicatricial alopecia. 5 alpha-reductase inhibitor (5ARI) has been reported with some treatment success in severe cases of FFA. OBJECTIVE: To carry out evidence-based analysis of articles published on treatment efficacy and safety of 5 alpha-reductase inhibitor for the treatment of FFA. METHODS: Articles published on the use of 5ARI to treat FFA between 2005 to 2017 were reviewed, analysed and graded according to the American College of Physicians outcome study grading system...
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29522406/impact-of-targeted-assistance-of-multiarticular-finger-musculotendons-on-the-coordination-of-finger-muscles-during-isometric-force-production
#20
Sang Wook Lee, Billy C Vermillion, Shashwati Geed, Alexander W Dromerick, Derek G Kamper
Neurological injuries often cause degraded motor control. While rehabilitation efforts typically focus on movement kinematics, abnormal muscle activation patterns are often the primary source of impairment. Muscle-based therapies are likely more effective than joint-based therapy. In this paper, we examined the feasibility of biomimetic input mimicking the action of human musculotendons in altering hand muscle coordination. Twelve healthy subjects produced a submaximal isometric dorsal fingertip force, while a custom actuator provided assistance mirroring the actions of either the extrinsic extensor or the intrinsic muscles of the index finger...
March 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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