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https://www.readbyqxmd.com/read/28227840/virtual-reality-for-pediatric-neuro-rehabilitation-adaptive-visual-feedback-of-movement-to-engage-the-mirror-neuron-system
#1
Roopeswar Kommalapati, Konstantinos P Michmizos, Roopeswar Kommalapati, Konstantinos P Michmizos, Roopeswar Kommalapati, Konstantinos P Michmizos
Sensorimotor therapy gives optimal results when patients are cognitively engaged into highly repetitive tasks, a goal that most children find hard to pursue. This paper presents the key developments of our ongoing effort to design an interactive rehabilitation environment that motivates physically impaired children throughout their therapy. The continuous motivation is achieved by the system adapting fundamental therapeutic components to the performance of each child. The relevant movement is mirrored to an animated character projected in front of the child...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227561/mirror-therapy-combined-with-functional-electrical-stimulation-for-rehabilitation-of-stroke-survivors-ankle-dorsiflexion
#2
Ghadir Salhab, Ahmad Rifaii Sarraj, Soha Saleh, Ghadir Salhab, Ahmad Rifaii Sarraj, Soha Saleh, Ahmad Rifaii Sarraj, Ghadir Salhab, Soha Saleh
This study investigates the effect of combining both mirror therapy with Electrical Stimulation (ES) on improvement of the function of lower extremity compared to conventional therapy. 18 stroke survivors (sub acute stage) were recruited, 9 of them were randomly assigned to receive conventional treatment and another 9 started the mirror therapy combined with ES treatment. Duration of each session in both interventions was 50 minutes, done 4 times per week over two weeks. After 2 weeks, subjects took one week rest before switching they type of treatment; those started with conventional therapy continued with mirror therapy combined with ES, and vice versa...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28211829/virtual-and-augmented-reality-in%C3%A2-the%C3%A2-treatment-of-phantom-limb-pain-a%C3%A2-literature-review
#3
Justin Dunn, Elizabeth Yeo, Parisah Moghaddampour, Brian Chau, Sarah Humbert
BACKGROUND: Phantom limb pain (PLP), the perception of discomfort in a limb no longer present, commonly occurs following amputation. A variety of interventions have been employed for PLP, including mirror therapy. Virtual Reality (VR) and augmented reality (AR) mirror therapy treatments have also been utilized, and have the potential to provide an even greater immersive experience for the amputee. However, there is not currently a consensus on the efficacy of VR and AR therapy. OBJECTIVE: The aim of this review is to evaluate and summarize the current research on the effect of immersive VR and AR in the treatment of PLP...
February 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28210569/infant-acute-myocarditis-mimicking-acute-myocardial-infarction
#4
Maher Jedidi, Samia Tilouche, Tasnim Masmoudi, Maha Sahnoun, Youssef Chkirbène, Sarra Mestiri, Lamia Boughamoura, Mohamed Ben Dhiab, Mohamed Kamel Souguir
Myocarditis is an inflammatory disease of the myocardium with heterogeneous clinical manifestations and progression. In clinical practice, although there are many methods of diagnosis of acute myocarditis, the diagnosis remains an embarrassing dilemma for clinicians. The authors report the case of 9-month-old infant who was brought to the Pediatric Emergency Department with sudden onset dyspnea. Examination disclosed heart failure and resuscitation was undertaken. The electrocardiogram showed an ST segment elevation in the anterolateral leads with a mirror image...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28210035/effects-of-observation-of-hand-movements-reflected-in-a-mirror-on-cortical-activation-in-patients-with-stroke
#5
Moon-Young Chang, Hwan-Hee Kim, Kyeong-Mi Kim, Jae-Seop Oh, Chel Jang, Tae-Hyung Yoon
[Purpose] The purpose of this study was to examine what changes occur in brain waves when patients with stroke receive mirror therapy intervention. [Subjects and Methods] The subjects of this study were 14 patients with stroke (6 females and 8 males). The subjects were assessed by measuring the alpha and beta waves of the EEG (QEEG-32 system CANS 3000). The mirror therapy intervention was delivered over the course of four weeks (a total of 20 sessions). [Results] Relative alpha power showed statistically significant differences in the F3, F4, O1, and O2 channels in the situation comparison and higher for hand observation than for mirror observation...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28191695/breast-cancer-in-pregnancy-avoiding-fetal-harm-when-maternal-treatment-is-necessary
#6
Christina N Cordeiro, Mary L Gemignani
The management of breast cancer during pregnancy poses unique challenges and requires a multi-disciplinary approach. In this review, we discuss the treatment of breast cancer in pregnancy and recent updates regarding the safety of surgical and chemotherapeutic treatments, including both oncologic and fetal outcomes. The treatment of breast cancer during pregnancy mirrors that outside of pregnancy, with a few important differences dictated by the balance of maternal versus fetal health. Overall, surgical treatment, neo-adjuvant chemotherapy, and/or adjuvant chemotherapy are feasible in most women during pregnancy...
February 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28184331/verticillin-a-inhibits-leiomyosarcoma-and-malignant-peripheral-nerve-sheath-tumor-growth-via-induction-of-apoptosis
#7
A Zewdu, G Lopez, D Braggio, C Kenny, D Constantino, H K Bid, K Batte, O H Iwenofu, N H Oberlies, C J Pearce, A M Strohecker, D Lev, R E Pollock
OBJECTIVE: The heterogeneity of soft tissue sarcoma (STS) represents a major challenge for the development of effective therapeutics. Comprised of over 50 different histology subtypes of various etiologies, STS subsets are further characterized as either karyotypically simple or complex. Due to the number of genetic anomalies associated with genetically complex STS, development of therapies demonstrating potency against this STS cluster is especially challenging and yet greatly needed...
November 2016: Clinical & Experimental Pharmacology
https://www.readbyqxmd.com/read/28163987/mirror-therapy-for-phantom-limb-pain-at-a-pediatric-oncology-institution
#8
Doralina L Anghelescu, Cassandra N Kelly, Brenda D Steen, Jianrong Wu, Huiyun Wu, Brian M DeFeo, Kristin Scobey, Laura Burgoyne
BACKGROUND AND PURPOSE/OBJECTIVE: Mirror therapy has not been reported for phantom limb pain (PLP) in pediatric oncology. Our aims are to describe the incidence and duration of PLP post-amputation, the duration of follow-up, pain scores and pain medications, and the differences between a group that received mirror therapy (MT) in addition to the standard treatment and a group that received only the standard treatment (non-MT). METHODS: A retrospective review of patients' medical records from June 2009 to March 2015 was completed...
July 2016: Rehabilitation Oncology
https://www.readbyqxmd.com/read/28148893/stem-cell-cultures-derived-from-pediatric-brain-tumors-accurately-model-the-originating-tumors
#9
Anna Wenger, Susanna Larsson, Anna Danielsson, Kirstine Juul Elbæk, Petronella Kettunen, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Claes Nordborg, Elizabeth Schepke, Helena Carén
Brain tumors are the leading cause of cancer-related death in children but high-grade gliomas in children and adolescents have remained a relatively under-investigated disease despite this. A better understanding of the cellular and molecular pathogenesis of the diseases is required in order to improve the outcome for these children. In vitro-cultured primary tumor cells from patients are indispensable tools for this purpose by enabling functional analyses and development of new therapies. However, relevant well-characterized in vitro cultures from pediatric gliomas cultured under serum-free conditions have been lacking...
January 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28135747/-flexible-guidance-of-ultra-short-laser-pulses-in-ophthalmic-therapy-systems
#10
J Blum, M Blum, M S Rill, J Haueisen
In the last 20 years, the role of ultrashort pulsed lasers in ophthalmology has become increasingly important. However, it is still impossible to guide ultra-short laser pulses with standard glass fibres. The highly energetic femtosecond pulses would destroy the fibre material, and non-linear dispersion effects would significantly change beam parameters. In contrast, photonic crystal fibres mainly guide the laser pulses in air, so that absorption and dispersive pulse broadening have essentially no effect. This article compares classical beam guidance with mirrors, lenses and prisms with photonic crystal fibres and describes the underlying concepts and the current state of technology...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28105770/does-peritoneal-protein-transport-increase-with-peritoneal-dialysis-therapy-duration-and-lead-to-extracellular-water-overload-in-peritoneal-dialysis-patients
#11
Cate Goodlad, Andrew Davenport
Faster peritoneal transport status has been associated with adverse outcomes for peritoneal dialysis (PD) patients. Peritoneal protein clearance, through large pores, may be a surrogate marker of local inflammation. We wished to determine whether peritoneal protein transport increased with PD duration or was associated with extracellular water (ECW) expansion. We studied the relationships between 4 h Dialysate (D)/Serum (S) protein and ECW excess, using multifrequency bioelectrical impedance assessments, in 103 PD patients with up to 4 years of prospectively collected peritoneal equilibrium test (PET) results...
February 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28100786/inositol-depletion-induced-by-acute-treatment-of-the-bipolar-disorder-drug-valproate-increases-levels-of-phytosphingosine
#12
Shyamalagauri Jadhav, Sarah Russo, L Ashley Cowart, Miriam L Greenberg
Bipolar disorder (BD) is a severe psychiatric illness affecting ~2% of the world population. Valproate (VPA) and lithium, though widely used for the treatment of BD, are not universally effective. These drugs have been shown to cause inositol depletion, but translating this observation to a specific therapeutic mechanism has been difficult, hampering the development of more effective therapies. We have shown previously in yeast that chronic VPA treatment induces the unfolded protein response due to increasing ceramide levels...
January 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28078563/changes-in-first-line-injectable-disease-modifying-therapy-for-multiple-sclerosis-predictors-of-non-adherence-switching-discontinuation-and-interruption-of-drugs
#13
Luca Degli Esposti, Carlo Piccinni, Diego Sangiorgi, Valentina Perrone, Lucia Aledda, Maria Giovanna Marrosu, Fabio Lombardo
This study was aimed to describe changes of Disease-Modifying Treatments (DMT) in an Italian cohort of patients with multiple sclerosis (MS) and to identify predictors of therapeutic modifications. Patients with MS and treated with the first-line injectable DMT (interferons-IFNs or glatiramer) between 1/7/2009 and 31/10/2012 were selected from administrative databases of the MS Center of Cagliari (Sardinia, Italy). Socio-demographic, therapeutic, and clinical information was collected in the 6 months preceding the index date...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28074285/t-cell-receptor-repertoire-usage-in-cancer-as-a-surrogate-marker-for-immune-responses
#14
REVIEW
David Schrama, Cathrin Ritter, Jürgen C Becker
Characterizing the interaction of cancer cells with the host adaptive immune system is critical for understanding tumor immunology and the modus operandi of immunotherapeutic interventions to treat cancer. As the key cellular effectors of adaptive immunity, T cells are endowed with specialized receptors (the T cell receptor; TCR), to recognize and to eliminate cancer cells. The diversity of the TCR repertoire results from specialized genetic diversification mechanisms that generate an incredible variability allowing recognizing extensive collections of antigens...
January 10, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28069679/survey-of-pharmacist-prescribing-practices-in-alberta
#15
Lisa M Guirguis, Christine A Hughes, Mark J Makowsky, Cheryl A Sadowski, Theresa J Schindel, Nese Yuksel
PURPOSE: Results of a survey to characterize pharmacist prescribing in the Canadian province of Alberta are reported. METHODS: A cross-sectional survey of a random sample of pharmacists registered with the Alberta College of Pharmacists was conducted. The survey was developed in four stages, with evidence of reliability and construct validity compiled. Analysis of variance and chi-square testing were used to compare prescribing behaviors. RESULTS: Three hundred fifty of 692 invited pharmacists (51%) completed the survey, with 76...
January 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28048224/su-g-brb-09-kompeito-shot-development-of-a-novel-verification-system-for-3d-beam-alignment-including-the-sag-of-gantry-head
#16
M Tsuneda, T Nishio, A Saito, K Hioki, D Kawahara, Y Ochi, K Matsushita, S Tanaka, S Ozawa, Y Nagata
PURPOSE: High accuracy of beam axis is required for high-precision radiation therapy. It is impossible to quantitatively and directly evaluate the sagging effect of the gantry head using current methods (star-shot and Winston-Lutz tests) when the gantry head sags under the weight of MLC and X-Y jaws. We introduce a novel method "Kompeito-shot (3D star-shot)" for the verification of 3D beam alignment (3D isocentricity). This method enables direct measurement of the sagging effect. We developed the system and examined the concept of this system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046601/su-f-t-232-monthly-quality-assurance-in-external-beam-radiation-therapy-using-a-single-system
#17
K Ding, T Ji, I Iordachita, E Velarde, J Hyatt, J Wong
PURPOSE: Monthly quality assurance (QA) is time consuming for external beam radiation therapy, taking as long as 6-8 hours for each machine. It is due to the use and setup of multiple devices for different QA procedures. We have developed a single system with rotational capability for the measurement of both optical light and radiation which significantly reduces the time spent on Monthly QA. METHODS: A single system using mirrors, a phosphor screen and a CCD camera is housed on a cylindrical motor so that it can rotate 360 degrees...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041959/substrate-selectivity-of-dengue-and-zika-virus-ns5-polymerase-towards-2-modified-nucleotide-analogues
#18
Supanee Potisopon, François Ferron, Véronique Fattorini, Barbara Selisko, Bruno Canard
In targeting the essential viral RNA-dependent RNA-polymerase (RdRp), nucleotide analogues play a major role in antiviral therapies. In the Flaviviridae family, the hepatitis C virus (HCV) can be eradicated from chronically infected patients using a combination of drugs which generally include the 2'-modified uridine analogue Sofosbuvir, delivered as nucleotide prodrug. Dengue and Zika viruses are emerging flaviviruses whose RdRp is closely related to that of HCV, yet no nucleoside drug has been clinically approved for these acute infections...
December 30, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28032336/systematic-review-of-mirror-therapy-compared-with-conventional-rehabilitation-in-upper-extremity-function-in-stroke-survivors
#19
REVIEW
David Pérez-Cruzado, Jose Antonio Merchán-Baeza, Manuel González-Sánchez, Antonio I Cuesta-Vargas
BACKGROUND/AIM: Stroke is a leading cause of disability in developed countries. One of the most widespread techniques in clinical practice is mirror therapy (MT). To determine the effectiveness of MT over other methods of intervention in the recovery of upper limb function in people who have had a stroke. METHODS: A systematic review was conducted. The search string was established based on the last systematic review about MT that dated from 2009: "upper extremity" OR "upper limb "AND "mirror therapy" AND stroke...
December 29, 2016: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28025715/alzheimer-s-disease-experimental-models-and-reality
#20
REVIEW
Eleanor Drummond, Thomas Wisniewski
Experimental models of Alzheimer's disease (AD) are critical to gaining a better understanding of pathogenesis and to assess the potential of novel therapeutic approaches. The most commonly used experimental animal models are transgenic mice that overexpress human genes associated with familial AD (FAD) that result in the formation of amyloid plaques. However, AD is defined by the presence and interplay of both amyloid plaques and neurofibrillary tangle pathology. The track record of success in AD clinical trials thus far has been very poor...
February 2017: Acta Neuropathologica
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