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Genotoxicity of Fishes

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https://www.readbyqxmd.com/read/28213766/microelectrophoretic-study-of-environmentally-induced-dna-damage-in-fish-and-its-use-for-early-toxicity-screening-of-freshwater-bodies
#1
Bilal Hussain, Tayyaba Sultana, Salma Sultana, K A Al-Ghanim, Shahreef Masood, Muhammad Ali, Shahid Mahboob
This study investigates the potential of the comet and micronucleus assays of fish DNA as a means of screening the toxicity of aquatic environments. Catla catla and Cirrhinus mrigala collected from the River Chenab in Pakistan were used as a case study for the application of comet and micronucleus techniques. Comet and micronucleus assays were used to compare DNA damage in C. catla and C. mrigala collected from polluted areas of the River Chenab and farmed fish. Atomic absorption spectrophotometry showed an acute level of toxicity from Cd, Cu, Mn, Zn, Pb, Cr, Sn, and Hg in river water...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28185655/oxidative-stress-and-genotoxicity-biomarker-responses-in-tilapia-oreochromis-niloticus-exposed-to-environmental-concentration-of-1-nitropyrene
#2
Eugene T Bacolod, Seiichi Uno, Shiela S Villamor, Jiro Koyama
The present study aimed to assess whether environmental 1-nitropyrene (1-NP) concentration will induce genotoxicity and oxidative damages in tilapia, lives in estuarine and brackish water. Tilapia were exposed to waterborne 1-NP. Cellular antioxidant enzyme activity of glutathione peroxidase and oxidative damage, i.e., lipid peroxidation, protein and DNA oxidation were used as biomarkers of oxidative stress, while the micronucleus test was used for evaluation of chromosomal damage and was used as an indication of genotoxicity...
February 6, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28167441/effects-of-environmentally-relevant-concentrations-of-the-anti-inflammatory-drug-diclofenac-in-freshwater-fish-rhamdia-quelen
#3
Izonete Cristina Guiloski, Laercio Dante Stein Piancini, Ana Carolina Dagostim, Sabrina Loise de Morais Calado, Luis Fernando Fávaro, Suelen Lúcio Boschen, Marta Margarete Cestari, Cláudio da Cunha, Helena Cristina Silva de Assis
The presence of pharmaceuticals in the aquatic environment and its impact on humans and the ecosystem are emerging issues in environmental health. This study evaluated the potential biochemical, genetic and reproductive effects of the diclofenac by waterborne exposure, in a semi-static bioassay for 21 days. The fish Rhamdia quelen were exposed to environmental concentrations of diclofenac (0, 0.2, 2 and 20µg/L). The results showed that in the liver, diclofenac reduced the catalase and ethoxyresorufin- O- deethylase activities in fish exposed to 2µg/L, and superoxide dismutase in all exposed groups...
February 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28167386/dna-adducts-in-marine-fish-as-biological-marker-of-genotoxicity-in-environmental-monitoring-the-way-forward
#4
REVIEW
Daniela M Pampanin, Steven J Brooks, Bjørn Einar Grøsvik, Jérémie Le Goff, Sonnich Meier, Magne O Sydnes
DNA adducts in fish represent a very important genotoxicity endpoint in environmental monitoring, being a pre-mutagenic lesion that plays an essential role in the initiation of carcinogenesis. The analysis of DNA adducts is a challenging task due to the low concentration of the analyte. Methods are available to determine the presence of DNA adducts, although further knowledge is required to fully understand the nature of the adducts and responsible xenobiotics (i.e. position of adduct in DNA, most active xenobiotic and metabolite forms, structural information)...
April 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28160022/role-of-human-sulfotransferase-1a1-and-n-acetyltransferase-2-in-the-metabolic-activation-of-16-heterocyclic-amines-and-related-heterocyclics-to-genotoxicants-in-recombinant-v79-cells
#5
Matthieu Chevereau, Hansruedi Glatt, Daniel Zalko, Jean-Pierre Cravedi, Marc Audebert
Heterocyclic aromatic amines (HAAs) are primarily produced during the heating of meat or fish. HAAs are mutagenic and carcinogenic, and their toxicity in model systems depend on metabolic activation. This activation is mediated by cytochrome P450 (CYP) enzymes, in particular CYP1A2. Some studies have indicated a role of human sulfotransferase (SULT) 1A1 and N-acetyltransferase (NAT) 2 in the terminal activation of HAAs. In this study, we conducted a metabolism/genotoxicity relationship analysis for 16 HAAs and related heterocyclics...
February 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28159303/transcriptional-responses-of-zebrafish-to-complex-metal-mixtures-in-laboratory-studies-overestimates-the-responses-observed-with-environmental-water
#6
Ajay Pradhan, Per Ivarsson, Daniel Ragnvaldsson, Håkan Berg, Jana Jass, Per-Erik Olsson
Metals released into the environment continue to be of concern for human health. However, risk assessment of metal exposure is often based on total metal levels and usually does not take bioavailability data, metal speciation or matrix effects into consideration. The continued development of biological endpoint analyses are therefore of high importance for improved eco-toxicological risk analyses. While there is an on-going debate concerning synergistic or additive effects of low-level mixed exposures there is little environmental data confirming the observations obtained from laboratory experiments...
January 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28140694/genotoxic-and-hematological-effects-of-chlorpyrifos-exposure-on-freshwater-fish-labeo-rohita
#7
Muhammad Ismail, Rahat Ali, Muhammad Shahid, Muhammad Asaf Khan, Muhammad Zubair, Tayyaba Ali, Qaiser Mahmood Khan
Chlorpyrifos is a commonly used organophosphate insecticide that causes toxicological effects in aquatic organisms especially in fish. This study determined the effects of chlorpyrifos on the genotoxic and hematological parameters of freshwater fish, Labeo rohita. The genotoxic effects of different sublethal concentrations of chlorpyrifos were investigated in the erythrocytes of Labeo rohita (commonly known as Rohu) using the Micronucleus test. Effects of chlorpyrifos on the hematological parameters of the fish were also observed...
January 31, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28137363/assessment-of-the-genotoxicity-of-the-tyrosine-kinase-inhibitor-imatinib-mesylate-in-cultured-fish-and-human-cells
#8
Matjaž Novak, Bojana Žegura, Jana Nunić, Goran Gajski, Marko Gerić, Vera Garaj-Vrhovac, Metka Filipič
The selective tyrosine kinase inhibitor imatinib mesylate (IM) is a widely used anticancer drug. Recent studies showing that IM can induce DNA and chromosomal damage in crustaceans and higher plants prompted us to re-examine its potential genotoxicity. IM was not mutagenic in the Ames assay (Salmonella typhimurium). Cytotoxicity and genotoxicity were evaluated in vitro in zebrafish (Danio rerio) liver (ZFL), human hepatoma (HepG2), and human peripheral blood lymphocyte (HPBL) cells. Genotoxicity was determined with the comet assay and with the cytokinesis-block micronucleus cytome assay...
February 2017: Mutation Research
https://www.readbyqxmd.com/read/28131919/comet-assay-and-micronucleus-tests-on-oreochromis-niloticus-perciforme-cichlidae-exposed-to-raw-sugarcane-vinasse-and-to-phisicochemical-treated-vinasse-by-ph-adjustment-with-lime-cao
#9
Jorge E Correia, Cintya Ap Christofoletti, Yadira Ansoar-Rodríguez, Thays A Guedes, Carmem S Fontanetti
In Brazil vinasse, a main sugarcane distillery residue, stands out because every liter of alcohol generates 10-15 L of vinasse as waste. An alternative for the disposal of this waste is the fertirrigation of the sugarcane culture itself. However, the high amount released can saturate the soil and through leaching/percolation contaminate water resources. The aim of this study is verifying the toxic potential of vinasse in tilapias and effectiveness of the physicalchemical treatment of this waste with pH adjustment with lime (CaO)...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28118403/brachypodium-distachyon-a-useful-model-in-the-qualification-of-mutagen-induced-micronuclei-using-multicolor-fish
#10
Arita Kus, Jolanta Kwasniewska, Robert Hasterok
Brachypodium distachyon (Brachypodium) is now intensively utilized as a model grass species in various biological studies. Its favorable cytological features create a unique foundation for a convenient system in mutagenesis, thereby potentially enabling the 'hot spots' and 'cold spots' of DNA damage in its genome to be analyzed. The aim of this study was to analyze the involvement of 5S rDNA, 25S rDNA, the Arabidopsis-type (TTTAGGG)n telomeric sequence and the Brachypodium-originated centromeric BAC clone CB33J12 in the micronuclei formation in Brachypodium root tip cells that were subjected to the chemical clastogenic agent maleic hydrazide (MH)...
2017: PloS One
https://www.readbyqxmd.com/read/28091988/genotoxicity-and-cytotoxicity-reduction-of-the-polluted-urban-river-after-ecological-restoration-a-field-scale-study-of-jialu-river-in-northern-china
#11
Jie Sun, Rui Zhang, Long Qin, Haixiao Zhu, Yu Huang, Yingang Xue, Shuqing An, Xianchuan Xie, Aimin Li
To further treat the reclaimed municipal wastewater and rehabilitate the aquatic ecosystem of polluted urban rivers, an 18.5-km field-scale ecological restoration project was constructed along Jialu River, a polluted urban river which receives only reclaimed municipal wastewater from Zhengzhou City without natural upland water dilution. This study investigated the potential efficiency of water quality improvement, as well as genotoxicity and cytotoxicity reduction along the ecological restoration project of this polluted urban river...
January 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28055311/immunotoxicity-of-mercury-pathological-and-toxicological-effects
#12
Faheem Maqbool, Kamal Niaz, Fatima Ismail Hassan, Fazlullah Khan, Mohammad Abdollahi
Mercury (Hg) is toxic and hazardous metal that causes natural disasters in the earth's crust. Exposure to Hg occurs via various routes; like oral (fish), inhalation, dental amalgams, and skin from cosmetics. In this review, we have discussed the sources of Hg and its potential for causing toxicity in humans. In addition, we also review its bio-chemical cycling in the environment; its systemic, immunotoxic, genotoxic/carcinogenic, and teratogenic health effects; and the dietary influences; as well as the important considerations in risk assessment and management of Hg poisoning have been discussed in detail...
January 2, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28040614/recommendation-for-a-test-battery-for-the-ecotoxicological-evaluation-of-the-environmental-safety-of-construction-products
#13
Stefan Gartiser, Ines Heisterkamp, Ute Schoknecht, Nicole Bandow, N Michael Burkhardt, Monika Ratte, Outi Ilvonen
The European Construction Products Regulation allows Member States to adopt rules for evaluating the environmental impact of their buildings. The aim of the project was to develop recommendations for a test battery for the ecotoxicological assessment of the environmental impact of construction products for outdoor use and contribute to the European harmonization of test methods. From a shortlist of 39 products 20 products were included in the ecotoxicological testing program. Monolithic and plate-like construction products were eluted in the Dynamic Surface Leaching test (DSLT) in accordance with CEN/TS 16637-2, granular products were eluted in a one stage batch test in accordance with DIN EN 12457-1...
December 23, 2016: Chemosphere
https://www.readbyqxmd.com/read/28038348/i-biomarker-quantification-in-fish-exposed-to-crude-oil-as-input-to-species-sensitivity-distributions-and-threshold-values-for-environmental-monitoring
#14
Steinar Sanni, Carina Björkblom, Henrik Jonsson, Brit F Godal, Birgitta Liewenborg, Emily Lyng, Daniela M Pampanin
The aim of this study was to determine a suitable set of biomarker based methods for environmental monitoring in sub-arctic and temperate offshore areas using scientific knowledge on the sensitivity of fish species to dispersed crude oil. Threshold values for environmental monitoring and risk assessment were obtained based on a quantitative comparison of biomarker responses. Turbot, halibut, salmon and sprat were exposed for up to 8 weeks to five different sub-lethal concentrations of dispersed crude oil. Biomarkers assessing PAH metabolites, oxidative stress, detoxification system I activity, genotoxicity, immunotoxicity, endocrine disruption, general cellular stress and histological changes were measured...
April 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28033099/an-alternative-approach-to-studying-the-effects-of-zno-nanoparticles-in-cultured-human-lymphocytes-combining-electrochemistry-and-genotoxicity-tests
#15
Gina Branica, Marin Mladinić, Dario Omanović, Davor Želježić
Nanoparticle use has increased radically raising concern about possible adverse effects in humans. Zinc oxide nanoparticles (ZnO NPs) are among the most common nanomaterials in consumer and medical products. Several studies indicate problems with their safe use. The aim of our study was to see at which levels ZnO NPs start to produce adverse cytogenetic effects in human lymphocytes as an early attempt toward establishing safety limits for ZnO NP exposure in humans. We assessed the genotoxic effects of low ZnO NP concentrations (1...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28025689/single-low-dose-ionizing-radiation-induces-genotoxicity-in-adult-zebrafish-and-its-non-irradiated-progeny
#16
J Lemos, T Neuparth, M Trigo, P Costa, D Vieira, L Cunha, F Ponte, P S Costa, L F Metello, A P Carvalho
This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage...
February 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28024242/aneugenicity-and-clastogenicity-in-freshwater-fish-oreochromis-niloticus-exposed-to-incipient-safe-concentration-of-tannery-effluent
#17
Abel Weldetinsae, Mekibib Dawit, Abebe Getahun, H S Patil, Esayas Alemayehu, Melaku Gizaw, Moa Abate, Daniel Abera
Conventional effluent bioassays mostly rely on overt responses or endpoints such as apical and Darwinian fitness. Beyond the empirical observation, laboratory toxicity testing needs to rely on effective detection of prognostic biomarkers such as genotoxicity. Indeed, characterization of tannery effluent requires slotting in of genotoxic responses in whole effluent toxicity testing procedures. Hence, the prime objective of the present experimental investigation is to apply the technique of biological assay as a tool of toxicity testing to evaluate the induction of micronuclei (MN) in peripheral erythrocytes, and exfoliated cells of gill and kidney of O...
April 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27956245/neurotoxins-in-a-water-supply-reservoir-an-alert-to-environmental-and-human-health
#18
Sabrina Loise de Morais Calado, Juliana Wojciechowski, Gustavo Souza Santos, Valéria Freitas de Magalhães, André Andrian Padial, Marta Margarete Cestari, Helena Cristina da Silva de Assis
Reservoirs are important source of power generation, recreation, and water supply. Nevertheless, human activities have favored the bloom of toxic cyanobacteria in many reservoirs, which has resulted in environmental, social, and economic problems. This study aims to evaluate the water quality of a reservoir in South Brazil through the analysis of cyanobacteria and cyanotoxins PSTs (Paralytic Shellfish Toxins) and biomarkers of environmental contamination in fish. For this purpose, water samples and fish (Geophagus brasiliensis) (Perciformes: Cichlidae) were collected from September 2013 to May 2014...
December 10, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27940135/impaired-antioxidant-gene-expression-by-pesticide-residues-and-its-relation-with-other-cellular-biomarkers-in-nile-tilapia-oreochromis-niloticus-from-lake-burullus
#19
Abeer F El Nahas, Mohamed A S Abdel-Razek, Nashwa M Helmy, Shawky Mahmoud, Haneen A Ghazy
Organochlorines and Organophosphorus are the most commonly used pesticides. These pesticides constitute a considerable contaminating threat due to their excessive agricultural usage which in turn contaminates the aquatic system through agricultural drainage. The aim of this study was to evaluate water and tissue residues of both pesticides in O. niloticus obtained from three different sections in Lake Burullus, Egypt. Assessment of relative change in mRNA levels of GST and Vtg (oxidative stress indicator) was done and its relation with other cellular biomarkers including apoptosis, which is assessed by Cellular apoptosis susceptibility transcript level (CAS), comet assay and micronucleus assays (genotoxicity indicator)...
March 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27836175/cytogenotoxicity-screening-of-source-water-wastewater-and-treated-water-of-drinking-water-treatment-plants-using-two-in%C3%A2-vivo-test-systems-allium-cepa-root-based-and-nile-tilapia-erythrocyte-based-tests
#20
Chamini K Hemachandra, Asoka Pathiratne
Biological effect directed in vivo tests with model organisms are useful in assessing potential health risks associated with chemical contaminations in surface waters. This study examined the applicability of two in vivo test systems viz. plant, Allium cepa root based tests and fish, Oreochromis niloticus erythrocyte based tests for screening cytogenotoxic potential of raw source water, water treatment waste (effluents) and treated water of drinking water treatment plants (DWTPs) using two DWTPs associated with a major river in Sri Lanka...
January 1, 2017: Water Research
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