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Pathological myopia

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https://www.readbyqxmd.com/read/28009400/optical-coherence-tomography-imaging-in-the-management-of-the-argus-ii-retinal-prosthesis-system
#1
Francesco Parmeggiani, Katia De Nadai, Angela Piovan, Andrea Binotto, Sara Zamengo, Marzio Chizzolini
PURPOSE: To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS: This hospital-based case series included 3 blind patients who were uneventfully implanted with Argus II epiretinal device. These patients (2 with RP and 1 with CHM) were selected during the Argus™ II Retinal Prosthesis System PostMarket Surveillance Study Protocol...
November 25, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003976/application-of-optical-coherence-tomography-angiography-in-assessment-of-posterior-scleral-reinforcement-for-pathologic-myopia
#2
Jing Mo, An-Li Duan, Szy-Yann Chan, Xue-Fei Wang, Wen-Bin Wei
AIM: To investigate the effect of posterior scleral reinforcement (PSR) on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography (OCTA). METHODS: The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR (PSR group) for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary (RPC) flow density were measured by OCTA, and the measurements were compared between groups...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003787/pseudoduplication-of-the-optic-disc-in-moderate-myopia
#3
Zeynep Eylül Ercan, Aylin Karalezli, Gokcen Coban
We report a case of optic disc pseudoduplication without pathological myopia. A 79-year-old woman presented with gradually decreased vision. Fundus examination showed macular drusen in both eyes and subretinal haemorrhage in the left eye. Both optic discs appeared to be tilted and the left optic disc was seen to be inferiorly duplicated. Pseudodoubling of the optic discs can be caused by optic disc and peripapillary chorioretinal colobomas and pathological myopia. Considering that our patient did not have enough axial length to merit a diagnosis of pathological myopia and no pathological fundus lesions typical of elongated sclera, we suggest that acquired pseudoduplication is not a condition unique to pathological myopia, but can occur in all myopic patients...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27995965/identification-of-novel-x-linked-gain-of-function-rpgr-orf15-mutation-in-italian-family-with-retinitis-pigmentosa-and-pathologic-myopia
#4
Francesco Parmeggiani, Vanessa Barbaro, Katia De Nadai, Enrico Lavezzo, Stefano Toppo, Marzio Chizzolini, Giorgio Palù, Cristina Parolin, Enzo Di Iorio
The aim of this study was to describe a new pathogenic variant in the mutational hot spot exon ORF15 of retinitis pigmentosa GTPase regulator (RPGR) gene within an Italian family with X-linked retinitis pigmentosa (RP), detailing its distinctive genotype-phenotype correlation with pathologic myopia (PM). All members of this RP-PM family underwent a complete ophthalmic examination. The entire open reading frames of RPGR and retinitis pigmentosa 2 genes were analyzed by Sanger sequencing. A novel frame-shift mutation in exon ORF15 of RPGR gene (c...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977064/anti-vascular-endothelial-growth-factor-for-choroidal-neovascularisation-in-people-with-pathological-myopia
#5
REVIEW
Ying Zhu, Ting Zhang, Gezhi Xu, Lijun Peng
BACKGROUND: Choroidal neovascularisation (CNV) is a common complication of pathological myopia. Once developed, most eyes with myopic CNV (mCNV) experience a progression to macular atrophy, which leads to irreversible vision loss. Anti-vascular endothelial growth factor (anti-VEGF) therapy is used to treat diseases characterised by neovascularisation and is increasingly used to treat mCNV. OBJECTIVES: To assess the effects of anti-vascular endothelial growth factor (anti-VEGF) therapy for choroidal neovascularisation (CNV), compared with other treatments, sham treatment or no treatment, in people with pathological myopia...
15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27898445/pathologic-myopia
#6
Kyoko Ohno-Matsui
Pathologic myopia (PM) is the only myopia that causes the loss of best-corrected visual acuity. The main reason for best-corrected visual acuity loss is complications specific to PM, such as myopic maculopathy, myopic traction maculopathy, and myopic optic neuropathy (or glaucoma). The meta-analyses of the PM study group (META-PM study) made a classification system for myopic maculopathy. On the basis of this study, PM has been defined as eyes having atrophic changes equal to or more severe than diffuse atrophy...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898443/environmental-factors-and-myopia-paradoxes-and-prospects-for-prevention
#7
Kathryn Ailsa Rose, Amanda Nicole French, Ian George Morgan
The prevalence of myopia in developed countries in East and Southeast Asia has increased to more than 80% in children completing schooling, whereas that of high myopia has increased to 10%-20%. This poses significant challenges for correction of refractive errors and the management of pathological high myopia. Prevention is therefore an important priority. Myopia is etiologically heterogeneous, with a low level of myopia of clearly genetic origins that appears without exposure to risk factors. The big increases have occurred in school myopia, driven by increasing educational pressures in combination with limited amounts of time spent outdoors...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898442/epidemiology-of-pathologic-myopia-in-asia-and-worldwide
#8
Yee-Ling Wong, Seang-Mei Saw
The myopia epidemic in Asia is evident because the prevalence of high myopia among young adults is higher among Asian (6.8%-21.6%) compared with non-Asian populations (2.0%-2.3%). High myopia is linked to pathologic myopia (PM), which may cause irreversible visual impairment (VI). This review will highlight updates on the prevalence of PM and the associated VI from PM. The prevalence of PM among the middle-aged and elderly (0.9%-3.1%) is higher than the prevalence among children and adolescents (<0.2%). The PM lesions detected among older adults include advanced lesions, such as posterior staphyloma, chorioretinal atrophy, lacquer cracks, and Fuchs spot (in descending frequency of occurrence)...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27896533/characteristics-of-higher-order-aberrations-and-anterior-segment-tomography-in-patients-with-pathologic-myopia
#9
Kaori Kasahara, Naoyuki Maeda, Takashi Fujikado, Makoto Tomita, Muka Moriyama, Mutsumi Fuchihata, Kyoko Ohno-Matsui
PURPOSE: To investigate prospectively the characteristics in the higher-order aberrations and anterior segment tomography in patients with pathologic myopia. METHODS: One hundred and twelve consecutive highly myopic patients (mean age 43.4 ± 9.3 years, spherical equivalent of refractive error ≥8 D and an axial length ≥26.5 mm) were studied. Thirty-seven emmetropic individuals (mean age 37.0 ± 14.5 years, spherical equivalent of refractive error ≤ ±1 D) were analyzed as controls...
November 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27860316/prevalence-of-myopic-retinopathy-in-rural-central-india
#10
Jost B Jonas, Vinay Nangia, Rajesh Gupta, Krishna Bhojwani, Prabhat Nangia, Songhomitra Panda-Jonas
PURPOSE: The aim of this study was to determine the prevalence of myopic retinopathy (MR) in rural Central India. METHODS: The population-based Central India Eye and Medical Study included 4711 subjects (aged 30+ years). The participants underwent a detailed eye examination, including fundus photography. Myopic retinopathy was defined according to the Pathologic Myopia Study Group. RESULTS: Readable fundus photographs were available on 4561 (96...
November 17, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27853350/intravitreal-aflibercept-for-the-treatment-of-choroidal-neovascularization-associated-with-pathologic-myopia-a-pilot-study
#11
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova
PURPOSE: To determine the efficacy of intravitreal aflibercept injections for the treatment of patients with choroidal neovascularization (CNV) associated with pathologic myopia. METHODS: In this uncontrolled, prospective cohort study, 31 eyes of 30 consecutive patients affected by CNV associated with pathologic myopia were treated with intravitreal aflibercept (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical coherence tomography (OCT), neovascularization activity on fluorescein angiography, the number of aflibercept injections administered, and safety were examined as secondary endpoints...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27852402/-changes-of-ocular-biological-parameters-and-lumican-expression-in-the-monocularly-deprivation-myopic-model-of-mutant-lumican-transgenic-mice
#12
M S Sun, Y Z Song, F J Zhang, J Tao, Y B Liu
Objective: To investigate ocular changes in the monocularly deprivation myopic model of mutant Lumican transgenic mice. Comparing influences on biological parameters and sclera development between Lumican transgenic and form deprivation mice, and to prepare for further study of pathogenesis of pathological myopia (PM). Methods: Experimental research. Lumican transgenic mice and wild mice were monocularly lid-sutured at ten days after birth. All eyes were divided into 6 groups, group A(32 eyes): control eyes in transgenic mice; group B(34 eyes): sutured eyes in transgenic mice; group C(34 eyes): fellow eyes in transgenic mice; group D(28 eyes): control eyes in wild mice; group E(32 eyes): sutured eyes in wild mice; group F(32 eyes): fellow eyes in wild mice...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27842529/the-differences-in-level-of-trait-anxiety-among-girls-and-boys-aged-13-17-years-with-myopia-and-emmetropia
#13
Joanna B Łazarczyk, Beata Urban, Beata Konarzewska, Agata Szulc, Alina Bakunowicz-Łazarczyk, Ewa Żmudzka, Urszula Kowzan, Napoleon Waszkiewicz, Karolina Juszczyk-Zajkowska
BACKGROUND: A significant increase in myopia among children and teenagers can be observed all over the world. Yet at the same time, there is still an insignificant number of studies concerning this health problem. The aim of this study was to assess the level of trait anxiety among myopic group of teenagers in comparison to teenagers with emmetropia, and to confirm whether the level of trait anxiety relates to age and gender. METHODS: Two hundred thirty-nine students aged 13-17 years were included in the study...
November 14, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27834967/peripapillary-schisis-in-open-angle-glaucoma
#14
N Dhingra, R Manoharan, S Gill, M Nagar
PurposeTo report clinical features, topographic findings and outcome of 10 eyes with peripapillary schisis in open-angle glaucoma.Patients and methodsA retrospective review of patients with open-angle glaucoma who were noted to have peripapillary schisis on optical coherence tomography (OCT) were included. Serial peripapillary and macula infrared and OCT images, visual acuity, visual fields, and schisis appearance were reviewed.ResultsTen eyes of nine patients with open-angle glaucoma were detected to have the presence of peripapillary schisis...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27818204/retinal-microvascular-network-and-microcirculation-assessments-in-high-myopia
#15
Min Li, Ye Yang, Hong Jiang, Giovanni Gregori, Luiz Roisman, Fang Zheng, Bilian Ke, Dongyi Qu, Jianhua Wang
PURPOSE: To investigate the changes of the retinal microvascular network and microcirculation in high myopia. DESIGN: A cross-sectional, matched, comparative clinical study. PARTICIPANTS: Twenty eyes of twenty subjects with non-pathological high myopia (28 ± 5 Years) with a refractive error of -6.31 ± 1.23 Diopters (mean ± standard deviation) and twenty eyes of twenty age- and gender-matched control subjects (30 ± 6 years) with a refractive error of -1...
November 3, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27813523/two-year-outcomes-of-intravitreal-bevacizumab-for-choroidal-neovascularization-associated-with-a-dome-shaped-macula-in-pathologic-myopia
#16
J H Lee, S C Lee, S Choi, H J Koh, S S Kim, C S Lee
No abstract text is available yet for this article.
November 4, 2016: Eye
https://www.readbyqxmd.com/read/27800255/the-choroid-and-optical-coherence-tomography
#17
REVIEW
Taha Sezer, Muhammet Altınışık, İbrahim Arif Koytak, Mehmet Hakan Özdemir
The choroid is the most vascular tissue in the eye and it plays an important role in the pathophysiology of various common chorioretinal diseases such as central serous retinopathy, age-related macular degeneration and degenerative myopia. Quantitative assessment of the choroid has been quite challenging with traditional imaging modalities such as indocyanine green angiography and ultrasonography due to limited resolution and repeatability. With the advent of optical coherence tomography (OCT) technology, detailed visualization of the choroid in vivo is now possible...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27755380/six-year-outcomes-of-intravitreal-bevacizumab-for-choroidal-neovascularization-in-patients-with-pathologic-myopia
#18
Kaori Kasahara, Muka Moriyama, Kei Morohoshi, Takeshi Yoshida, Noriaki Simada, Natsuko Nagaoka, Tae Yokoi, Kosei Shinohara, Yuichiro Kaneko, Mitsuki Suga, Kyoko Ohno-Matsui
PURPOSE: To investigate the 6-year outcome of intravitreal bevacizumab (IVB) to treat eyes with active choroidal neovascularization (CNV) due to pathologic myopia. METHODS: Medical records of 36 eyes of 35 consecutive patients with high myopia (refractive error ≥8 D or axial length ≥26.5 mm) and active CNV, who had been treated with IVB and followed for ≥6 years were analyzed. The factors that predicted the best-corrected visual acuity (BCVA) at 6 years after IVB were determined by multiple regression analyses...
October 10, 2016: Retina
https://www.readbyqxmd.com/read/27755375/what-is-the-fundamental-nature-of-pathologic-myopia
#19
Kyoko Ohno-Matsui
PURPOSE: Despite being a major cause of visual impairment worldwide, pathologic myopia has not been clearly and consistently defined. This lack of a standardized definition has made comparisons among epidemiological studies difficult. Therefore, the purpose of this review was to summarize the definitions of pathologic myopia. METHODS: A literature search was conducted of Pubmed to identify reports presenting definitions of pathologic myopia. RESULTS: Although cut-off values for refractive error and increased axial length have been used in some studies, a definition based solely on such values is considered to just show a 'high degree of myopia'...
October 11, 2016: Retina
https://www.readbyqxmd.com/read/27749472/higher-order-aberrations-after-cyclopentolate-tropicamide-and-artificial-tear-drops-application-in-normal-eyes
#20
Negin Amirshekarizadeh, Hassan Hashemi, Ebrahim Jafarzadehpur, Ali Mirzajani, Abbasali Yekta, Mehdi Khabazkhoob
PURPOSE: To determine the effect of cyclopentolate, tropicamide, and artificial tear drops on higher-order aberrations (HOAs) in normal eyes with OPD-Scan III (Nidek Inc., Tokyo, Japan). METHODS: In this study, 189 eyes of individuals aged 20 to 35 years were selected as samples. Inclusion criteria were a corrected visual acuity of 20/20 or better, a minimum size of about 5 mm for the pupil in the dark, hyperopia and myopia less than 5 D, and astigmatism less than 2 D...
September 30, 2016: Eye & Contact Lens
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