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Pathological myopia

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https://www.readbyqxmd.com/read/29746414/five-year-outcomes-of-intravitreal-ranibizumab-for-choroidal-neovascularization-in-patients-with-pathologic-myopia
#1
Yuka Onishi, Tae Yokoi, Kaori Kasahara, Takeshi Yoshida, Natsuko Nagaoka, Kosei Shinohara, Yuichiro Kaneko, Mitsuki Suga, Kengo Uramoto, Akiko Ohno-Tanaka, Kyoko Ohno-Matsui
PURPOSE: To determine the 5-year outcome of intravitreal ranibizumab (IVR) for myopic choroidal neovascularization (CNV). METHOD: We retrospectively analyzed the medical records of 51 eyes of 51 consecutive patients with myopic CNV who had been treated with IVR with a minimum follow-up period of 5 years after the initial IVR injection. The factors that predicted the best-corrected visual acuity (BCVA) at 5 years after IVR were determined by multiple regression analysis...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29725825/lamellar-macular-holes-in-the-eyes-with-pathological-myopia
#2
Roberto dell'Omo, Gianni Virgili, Ferdinando Bottoni, Barbara Parolini, Serena De Turris, Attilo Di Salvatore, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To study the natural history and morphologic characteristics of lamellar macular holes (LMHs) in the eyes with pathological myopia. METHODS: Retrospective observational case series of 44 eyes of 44 patients examined at a single institutional vitreoretinal practice. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue fundus autofluorescence (B-FAF) to be included...
May 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29697590/clinical-features-of-lacquer-cracks-in-eyes-with-pathologic-myopia
#3
Xian Xu, Yuxin Fang, Kengo Uramoto, Natsuko Nagaoka, Kosei Shinohara, Tae Yokoi, Noriko Tanaka, Kyoko Ohno-Matsui
PURPOSE: To analyze the morphologic features of lacquer cracks (LCs), compare their detectability by different imaging instruments, and determine their progressive pattern. METHODS: The medical records of 47 highly myopic eyes of 33 patients with LCs were reviewed. Fundus fluorescein angiography was used as the primary method of identifying LCs, and the detection rate was compared with that by fundus autofluorescence and optical coherence tomography. RESULTS: A total of 176 LCs were detected in the 47 eyes...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29687336/clinical-efficacy-and-safety-of-current-interventions-for-choroidal-neovascularization-associated-with-rare-diseases-a-systematic-literature-review
#4
REVIEW
Natalie Bennett, Lokho John, Nishkarsh Likhar, Rumjhum Agrawal, Winfried M Amoaku
INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified...
April 23, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29681831/posterior-wall-collapse-in-high-myopia-following-cataract-surgery
#5
Galia A Deitz, Adam R Sweeney, Hoon C Jung
Purpose: We report a case of posterior globe collapse of an eye after initial recovery from uncomplicated cataract surgery in a patient with high myopia and discuss the course of management involving recognition and emergent air injection with globe reformation. Case Report: A 64-year-old functionally monocular male with a history of high myopia presented for follow-up after uncomplicated cataract surgery. Uncorrected distance visual acuity (UCDVA) at postoperative day 1 was 20/150 with an intraocular pressure (IOP) of 19 mm Hg...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29607214/choroidal-and-retinal-thickness-of-highly-myopic-eyes-with-early-stage-of-myopic-chorioretinopathy-tessellation
#6
Yanping Zhou, Minlu Song, Minwen Zhou, Yiming Liu, Fenghua Wang, Xiaodong Sun
Purpose: To investigate the choroidal thickness (CT) and retinal thickness (RT) in highly myopic tessellated eyes. Methods: In this study, 115 highly myopic eyes were recruited and divided as tessellated fundus ( n = 93) and normal fundus ( n = 22). RT and CT were quantified using optical coherence tomography with enhanced depth imaging (EDI-OCT). Correlation between subfoveal CT (SFCT) and tessellation was analyzed using logistic regression models. Results: Tessellated fundus eyes had thinner CT than did normal fundus eyes, while RT was not statistically different across groups...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29600987/the-use-of-optical-coherence-tomography-angiography-for-detecting-choroidal-neovascularization-compared-to-standard-multimodal-imaging
#7
T Soomro, J Talks
PurposeTo assess OCT angiography (OCTA) effectiveness at detecting choroidal neovascularization (CNV) in cases of suspected neovascular age related macular degeneration (nAMD), chronic central serous retinopathy (cCSR) and pathological myopia compared to FFA and how it compares to a multimodal approach (OCT, FFA and ICGA) for detecting the vascular network.MethodsThis was a retrospective observational cohort study of patients who had clinical and/or OCT findings suggestive of CNV, having further investigation with FFA, with or without ICG, and had same day OCTA using the Heidelberg Spectralis OCT2 beta angiography module...
March 30, 2018: Eye
https://www.readbyqxmd.com/read/29600174/outcomes-of-transconjunctival-sutureless-27-gauge-vitrectomy-for-vitreoretinal-diseases
#8
Jie Li, San-Mei Liu, Wen-Tao Dong, Fang Li, Cai-Hong Zhou, Xiao-Dan Xu, Jie Zhong
AIM: To evaluate the safety and efficacy profile of 27-gauge (27G) pars plana vitrectomy (PPV) for the treatment of various vitreoretinal diseases. METHODS: The clinical outcomes of 61 eyes (58 patients) with various vitreoretinal diseases following 27G PPV were retrospectively reviewed. RESULTS: Surgical indications included rhegmatogenous retinal detachment ( n =24), full-thickness macular hole ( n =12), diabetic retinopathy ( n =11), vitreous hemorrhage ( n =6), Eales disease ( n =4), pathological myopia-related vitreous floater ( n =2), and macular epiretinal membrane ( n =2)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29572456/macular-assessment-of-preoperative-optical-coherence-tomography-in-ageing-chinese-undergoing-routine-cataract-surgery
#9
Xiaoli Huang, Zhengwei Zhang, Jie Wang, Xiaomei Meng, Tiantian Chen, Zhifeng Wu
This retrospective consecutive case series aimed to evaluate spectral-domain optical coherence tomography (SD-OCT) for occult macular disease recognition preoperatively in patients scheduled for routine cataract surgery. All patients scheduled for cataract surgery underwent macular SD-OCT. Scans were reviewed for retinal, retinal pigment epithelium and vitreomacular interface abnormalities. For the subgroup analysis, the following information was collected: age; sex; and diabetes, hypertension, myopia, glaucoma, post intra-ocular surgery, endophotocoagulation, retinal vasculopathy and uveitis statuses...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29554812/clinical-applications-of-optical-coherence-tomography-angiography-what-we-have-learnt-in-the-first-3-years
#10
Salomon Y Cohen, Alexandra Miere, Sylvia Nghiem-Buffet, Franck Fajnkuchen, Eric H Souied, Sarah Mrejen
A review of the literature from 2014 to 2016 was conducted, focusing on the results of optical coherence tomography angiography in different chorioretinal diseases. In only 3 years, optical coherence tomography angiography has been shown to be an effective tool for diagnosing choroidal neovascularization complicating age-related macular degeneration, pathologic myopia, and inflammatory conditions. The technique has sometimes been considered superior to conventional multimodal imaging, for example, in choroidal neovascularization associated with chronic central serous chorioretinopathy or multifocal choroiditis...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29506863/efficacy-of-a-deep-learning-system-for-detecting-glaucomatous-optic-neuropathy-based-on-color-fundus-photographs
#11
Zhixi Li, Yifan He, Stuart Keel, Wei Meng, Robert T Chang, Mingguang He
PURPOSE: To assess the performance of a deep learning algorithm for detecting referable glaucomatous optic neuropathy (GON) based on color fundus photographs. DESIGN: A deep learning system for the classification of GON was developed for automated classification of GON on color fundus photographs. PARTICIPANTS: We retrospectively included 48 116 fundus photographs for the development and validation of a deep learning algorithm. METHODS: This study recruited 21 trained ophthalmologists to classify the photographs...
March 2, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29492074/retinal-and-choroidal-thickness-in-patients-with-high-myopia-without-maculopathy
#12
Kuddusi Teberik, Murat Kaya
Objective: To evaluate macular choroidal thickness (CT) and retinal thickness in Turkish patients with high myopia without maculopathy and in normal subjects and to examine the association with age, axial length (AL), best corrected visual acuity (BCVA), cycloplegic refraction, and spherical equivalent (SE). Methods: This prospective study was performed between January 2015 and June 2016 in the Department of Ophthalmology, Duzce University Medical Faculty. It had 65 individuals (30 patients with high myopia, 35 healthy subjects)...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29463226/acquired-distance-esotropia-associated-with-myopia-in-the-young-adult
#13
Ke Zheng, Tian Han, Yinan Han, Xiaomei Qu
BACKGROUND: To describe the clinical features of acquired progressive esotropia, with a larger angle at distance than near, associated with myopia in young adults. METHODS: Eleven adults (ages ranging from 18 to 37 years) with constant or intermittent horizontal diplopia at distance were recruited. Subjective refraction, ocular alignment, fusional amplitudes and horizontal eye movements were measured at distance and near. RESULTS: Distance esotropia varied from 20 to 60 prism diopters (PD)...
February 20, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29453956/frequent-mutations-of-retnet-genes-in-eohm-further-confirmation-in-325-probands-and-comparison-with-late-onset-high-myopia-based-on-exome-sequencing
#14
Lin Zhou, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Qingjiong Zhang
In our previous study, potential pathological mutations of RetNet genes were detected in 23.8% (71/298) of probands with early-onset high myopia (eoHM), based on whole exome sequencing (WES). The current study aimed to confirm this finding in an additional 325 probands with eoHM and to clarify its specificity by comparison of 195 probands with late-onset high myopia (loHM). Variants in the 234 RetNet genes were selected from whole-exome sequencing data and were filtered using multistep bioinformatics analyses...
February 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29443802/full-thickness-macular-hole-with-macular-intrachoroidal-cavitation-in-a-patient-with-pathologic-myopia
#15
Nurgül Örnek, Kemal Örnek
PURPOSE: To describe a full-thickness macular hole (MH) opening to macular intrachoroidal cavitation in a patient with pathologic myopia. METHODS: Full ophthalmologic examination, fundus camera (Topcon TRC; Topcon Co, Tokyo, Japan), optical coherence tomography (RetinaScan Advanced RS-3000; NIDEK, Gamagori, Japan) imaging, and cataract surgery. RESULTS: A 61-year-old woman admitted with decreased vision in the left eye. Visual acuity was counting fingers from 30 cm...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29437569/myopia-its-historical-contexts
#16
REVIEW
Paulus T V M de Jong
Worldwide, and especially in Asia, myopia is a major vision-threatening disorder. From AD 1600 on, to prevent myopia, authors warned against near work without sufficient pauses. There was an abundance of theories about the causes of myopia, the most common one being the necessity of extra convergence on nearby work with thickened extraocular muscles and elevated intraocular pressure. Ocular tenotomies against myopia were in vogue for a while. Axial lengthening of the eye in myopia was mentioned around 1700, but it took 150 years to become accepted as the most prevalent sign of high myopia...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29397539/acquired-myopia-in-vogt-koyanagi-harada-disease
#17
Hiroyuki Takahashi, Hiroshi Takase, Yukiko Terada, Manabu Mochizuki, Kyoko Ohno-Matsui
PURPOSE: To analyze the change in refractive error and the axial length of chronic Vogt-Koyanagi-Harada (VKH) disease. METHODS: Medical records of 106 eyes of 54 adult VKH patients were analyzed. The refractive error and the axial length were compared between the baseline (defined as the time point at least 2 weeks after acute stage of VKH) and the final visit. The rate of the eyes with significant myopia progression [defined as refraction change toward myopia > 1 diopter (D)] was examined...
February 3, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29390361/comparison-of-the-efficacy-of-intravitreal-ranibizumab-for-choroidal-neovascularization-due-to-pathological-myopia-with-and-without-a-dome-shaped-macula
#18
COMPARATIVE STUDY
Bincui Cai, Jin Yang, Shuang Li, Linni Wang, Lu Chen, Xiaorong Li, Zhiqing Li
Ranibizumab injection in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) with and without a dome-shaped macula (DSM).Prospective observational study.A total of 24 patients (24 eyes) with angiographic evidence of CNV secondary to PM were divided into 2 groups: eyes with a DSM and eyes without DSM. All patients received a baseline intravitreal ranibizumab injection. Additional injections were considered at each follow-up visit. Best-corrected visual acuity (BCVA) and optical coherence tomography were tested monthly through 12 months of follow-up...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29371011/progression-of-myopic-maculopathy-during-18-year-follow-up
#19
Yuxin Fang, Tae Yokoi, Natsuko Nagaoka, Kosei Shinohara, Yuka Onishi, Tomoka Ishida, Takeshi Yoshida, Xian Xu, Jost B Jonas, Kyoko Ohno-Matsui
PURPOSE: To examine the progression pattern of myopic maculopathy. DESIGN: Retrospective, observational case series. PARTICIPANTS: Highly myopic patients who had been followed up for 10 years or more. METHODS: Using fundus photographs, myopic features were differentiated according to Meta-analysis of Pathologic Myopia (META-PM) Study Group recommendations. MAIN OUTCOME MEASURES: Progression pattern of maculopathy...
January 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29369230/longitudinal-changes-in-disc-and-retinal-lesions-among-highly-myopic-adolescents-in-singapore-over-a-10-year-period
#20
Yee-Ling Wong, Yang Ding, Charumathi Sabanayagam, Chee-Wai Wong, Pavan Verkicharla, Kyoko Ohno-Matsui, Donald Tan, Anna Chwee-Hong Yeo, Quan V Hoang, Ecosse Lamoureux, Seang-Mei Saw
OBJECTIVES: To examine the progression pattern of disc and retinal lesions in highly myopic Chinese adolescents over a 10-year period in Singapore. METHODS: This longitudinal study included Chinese participants who showed high myopia (spherical equivalent [SE] worse than or equal to -5 diopters [D]), no history of refractive surgery, and available fundus photographs at both 2006 (baseline) and 2016 (10-year follow-up) visits. Forty-four adolescents (aged 12-16 years at baseline) who were re-examined later at follow-up were included...
January 22, 2018: Eye & Contact Lens
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