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https://www.readbyqxmd.com/read/29244804/conditional-knockout-mice-for-the-distal-appendage-protein-cep164-reveal-its-essential-roles-in-airway-multiciliated-cell-differentiation
#1
Saul S Siller, Himanshu Sharma, Shuai Li, June Yang, Yong Zhang, Michael J Holtzman, Wipawee Winuthayanon, Holly Colognato, Bernadette C Holdener, Feng-Qian Li, Ken-Ichi Takemaru
Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport. Despite their clear importance to human biology and health, the molecular mechanisms underlying multiciliated cell differentiation are poorly understood. Prior studies implicate the distal appendage/transition fiber protein CEP164 as a central regulator of primary ciliogenesis; however, its role in multiciliogenesis remains unknown...
December 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29243819/novel-dietary-supplement-associationreduces-symptoms-in-endometriosis-patients
#2
Pietro Giulio Signorile, Rosa Viceconte, Alfonso Baldi
Endometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29243795/the-effect-on-clinical-results-of-adding-recombinant-lh-in-late-phase-of-ovarian-stimulation-of-patients-with-repeated-implantation-failure-a-pilot-study
#3
A Rahman, D Francomano, F Sagnella, F Lisi, C Manna
OBJECTIVE: To evaluate the efficacy of recombinant LH (r-LH) addition in the late phase of ovarian stimulation in patients with repeated implantation failure (RIF). PATIENTS AND METHODS: 66 infertile couples undergoing ICSI treatment due to male factor were allocated to group A (33) and to group B (33). Group A (29 subjects) received recombinant FSH (r-FSH) supplemented by r-LH in the late follicular phase starting the same day of GnRH-antagonist (GnRH-ant) administration, and group B (32 subjects) received r-FSH alone...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243443/-effect-of-clomiphene-citrate-and-dingkun-dan-on-ovulation-induction-and-clinical-pregnancy-of-polycystic-ovary-syndrome
#4
Lan Chen, Yong Tan, Shu-Ping Chen
The evaluation is based on clomiphene citrate (CC)+gonadotropin (Gn), clinical study on CC and Dingkun Dan's treatment on ovulation induction and clinical pregnancy effect of PCOS, and to provide ideas and methods for traditional Chinese medicine assisted reproductive treatment. This study selected 60 PCOS infertility patients treated with ovulation induction in reproductive medicine clinic, Jiangsu Province Hospital of traditional Chinese medicine during 2015-10-01-2017-04-23. They were randomly divided into two groups: Group A (CC+Gn+HCG) and Group B (CC+Gn+Dingkun Dan)...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243340/testicular-sperm-extraction-after-laparoscopic-orchiectomy-for-bilateral-postpubertal-intra-abdominal-cryptorchidism-what-chance-of-sperm-retrieval
#5
G Cito, P A Della Camera, S Degli Innocenti, M E Coccia, G Nesi, A Cocci, S Morselli, A Minervini, M Carini, M Serni, M Gacci, A Natali
Infertility occurs in up to 54% of men with bilateral undescended testes. Orchiectomy is considered the best therapeutic approach, especially when cryptorchidism is diagnosed in adulthood, due to a high risk of malignancy. A 33-year-old man was referred with a clinical presentation of empty scrotum and an ultrasonography and magnetic resonance imaging evaluation of intra-abdominal bilateral cryptorchidism. Follicle-stimulating hormone was 23.20 IU/L, luteinising hormone was 14.10 IU/L, total testosterone was 12...
December 15, 2017: Andrologia
https://www.readbyqxmd.com/read/29243253/healthcare-provider-attitudes-regarding-the-provision-of-assisted-reproductive-services-for-hiv-affected-couples-in-addis-ababa-ethiopia
#6
Alana N Pinsky, Kylie Steenbergh, Heather M Boyd, Belen Michael, Delayehu Bekele, Emily Kobernik, Lia Tadesse Gebremedhin, Okeoma Mmeje
OBJECTIVE: To evaluate the acceptability and feasibility of providing assisted reproductive services as part of routine HIV care and treatment in Ethiopia. METHODS: The present cross-sectional study using semistructured in-depth interviews was conducted at St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia, during July 2014 and July 2015. The interviews assessed the perspectives of healthcare providers (HCPs) regarding the reproductive desires of HIV-affected couples, on assisting them in achieving pregnancy, and on the facilitators and barriers to offering such services as part of routine HIV care...
December 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29243149/ferulic-acid-protects-against-radiation-induced-testicular-damage-in-male-rats-impact-on-sirt1-and-parp1
#7
Hala O El-Mesallamy, Rania A Gawish, Al-Aliaa M Sallam, Hanan A Fahmy, Ahmed S Nada
Ionizing radiation is a major contributor to male infertility by destroying spermatogenesis. Therefore, the need for an effective radio-protective agent is evident. The objective of the present study was to investigate the potential radio-protective effect of ferulic acid (FA) on radiation-induced testicular damage. Mature male Sprague-Dawley rats were either exposed to a single-dose gamma radiation (5 Gy) and/or treated with FA (50 mg/kg), daily for 7 days before irradiation. Sirtuin1 (SIRT1), poly (ADP-ribose) polymerase 1 (PARP1), cytosolic calcium content, and the male reproductive functions (sperm head abnormality) as well as oxidative stress markers were assessed 7 days after irradiation...
December 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29242974/effect-of-intramural-fibroid-on-uterine-and-endometrial-vascularity-in-infertile-women-scheduled-for-in-vitro-fertilization
#8
Ahmed Kamel, Akmal El-Mazny, Wafaa Ramadan, Suzy Abdelaziz, Sherine Gad-Allah, Hany Saad, Ahmed M Hussein, Emad Salah
PURPOSE: To study the effect of intramural fibroids on uterine and endometrial vascularity in infertile women scheduled for in-vitro fertilization (IVF). METHODS: 3D power Doppler was used to measure the endometrial volume and blood flow indices in 182 women with intramural fibroids not affecting the uterine cavity and compared them to a matched control group without fibroids. RESULTS: There was significantly increased vascularity in the endometrium of the fibroid group as denoted by higher endometrial VI (p = 0...
December 14, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29242633/sexual-function-in-women-with-polycystic-ovary-syndrome-and-their-hormonal-and-clinical-correlations
#9
Fatemeh Nasiri Amiri, Fahimeh Ramezani Tehrani, Sedighe Esmailzadeh, Maryam Tohidi, Fereidoun Azizi, Zahra Basirat
Polycystic ovary syndrome (PCOS) appears to be related to sexual dysfunction, especially if associated with obvious clinical and hormonal signs of hyperandrogenism. The objective of this study was to determine the correlation of PCOS and its hormonal and clinical parameters with sexual function. This prospective, cross-sectional study conducted on 18-45-year-old PCOS women (according to the Rotterdam criteria), who were referred to the Reproductive Endocrinology Research Center, Iran, was invited to participate from January 2012 to December 2015...
December 15, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29242273/rbpj-mediates-uterine-repair-in-the-mouse-and-is-reduced-in-women-with-recurrent-pregnancy-loss
#10
Michael R Strug, Ren-Wei Su, Tae Hoon Kim, Alessandro Mauriello, Carlo Ticconi, Bruce A Lessey, Steven L Young, Jeong Mook Lim, Jae-Wook Jeong, Asgerally T Fazleabas
Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signal binding protein Jκ (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse uterus (Pgrcre/+Rbpjf/f ; Rbpj c-KO) results in subfertility, but we have found that these mice become infertile after pregnancy as a result of dysfunctional postpartum uterine repair, including delayed endometrial epithelial and myometrial regeneration...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29242267/-infertility-in-an-adult-cohort-with-primary-ciliary-dyskinesia-phenotype-gene-association-gert-jan-vanaken-laurence-bassinet-mieke-boon-rahma-mani-isabelle-honor%C3%A3-jean-francois-papon-harry-cuppens-martine-jaspers-natalie-lorent-andr%C3%A3-coste-estelle-escudier
#11
https://www.readbyqxmd.com/read/29242146/control-of-oocyte-meiotic-maturation-in-c-elegans
#12
REVIEW
Gabriela Huelgas-Morales
In virtually all sexually reproducing animals, oocytes arrest in meiotic prophase and resume meiosis in a conserved biological process called meiotic maturation. Meiotic arrest enables oocytes, which are amongst the largest cells in an organism, to grow and accumulate the necessary cellular constituents required to support embryonic development. Oocyte arrest can be maintained for a prolonged period, up to 50 years in humans, and defects in the meiotic maturation process interfere with the faithful segregation of meiotic chromosomes, representing the leading cause of human birth defects and female infertility...
December 11, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29241924/effects-of-growth-hormone-plus-gonadotropins-on-controlled-ovarian-stimulation-in-infertile-women-of-advanced-age-poor-responders-and-previous-in%C3%A2-vitro-fertilization-failure-patients
#13
Yao-Kai Ho, Tsung-Hsien Lee, Chun-I Lee, En-Hui Cheng, Chun-Chia Huang, Lii-Shung Huang, Maw-Sheng Lee
OBJECTIVE: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures. MATERIALS AND METHODS: We conducted a retrospective observational study of 436 patients undergoing GH cotreatment in ovarian stimulation. The first arm included 134 infertile women of advanced age. The second arm included 236 patients with one or more IVF previous treatment failures, and the third arm included 66 younger poor responders...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241915/predictors-of-failure-of-the-commonly-used-single-dose-methotrexate-protocol-for-treating-tubal-ectopic-pregnancies
#14
Eser Sefik Ozyurek, Evren Akmut, Erdal Kaya, Aysu Akca, Ozgur Akbayır
OBJECTIVES: This study identified patients who would benefit from an earlier additional medical intervention and/or continuing close surveillance even if commonly used parameters indicated sufficient medical treatment to determine markers of treatment failure. MATERIALS AND METHODS: A retrospective analysis of patients with a preliminary diagnosis of ectopic pregnancy treated with the single-dose methotrexate protocol. Group 1: cases cured with a single dose of methotrexate; Group 2: cases who required more than one dose of methotrexate or surgery following the first dose...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241080/paternal-urinary-concentrations-of-organophosphate-flame-retardant-metabolites-fertility-measures-and-pregnancy-outcomes-among-couples-undergoing-in-vitro-fertilization
#15
Courtney C Carignan, Lidia Mínguez-Alarcón, Paige L Williams, John D Meeker, Heather M Stapleton, Craig M Butt, Thomas L Toth, Jennifer B Ford, Russ Hauser
BACKGROUND: Use of organophosphate flame retardants (PFRs) has increased over the past decade following the phase out of some brominated flame retardants, leading to increased human exposure. We recently reported that increasing maternal PFR exposure is associated with poorer pregnancy outcomes among women from a fertility clinic. Because a small epidemiologic study previously reported an inverse association between male PFR exposures and sperm motility, we sought to examine associations of paternal urinary concentrations of PFR metabolites and their partner's pregnancy outcomes...
December 11, 2017: Environment International
https://www.readbyqxmd.com/read/29240537/infertility-and-self-rated-health-among-malawian-women
#16
Nisha Rao, Allahna Esber, Abigail Turner, Gladson Mopiwa, Joana Banda, Alison Norris
BACKGROUND: Infertility is prevalent and stigmatized in sub-Saharan Africa. Self-rated health, a subjective indicator that has been consistently related to objectively measured health, may be useful in evaluating the relationship between women's infertility and health. METHODS: Data were from surveys conducted from July 2014 to January 2015 with women aged 15 to 39 years (n = 915) as part of the initial assessment in a cohort study in Lilongwe district, Malawi...
December 14, 2017: Women & Health
https://www.readbyqxmd.com/read/29240334/do-in-vitro-fertilization-treatments-result-in-healthy-babies
#17
Noora Kaartinen, Helena Tinkanen
In Finland, the proportion of children born as a result of in vitro fertilization treatments is annually approximately 3.3%, and the percentage proportion of the population is growing. Their general somatic health status and cognitive development do not differ from spontaneously fertilized children. In vitro fertilization treatments are, however, associated with a slightly elevated risk of preterm delivery, low birth weight and structural abnormalities. The risk of childhood cancer does not appear to be increased in IVF children...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29238579/acute-abdomen-with-a-misleading-clinical-entity
#18
Jitendra Singh Nigam, Pushpanjali Ojha, Chitrawati Bal Gargade, Archana Hemant Deshpande
Massive ovarian edema is a rare, non-neoplastic solid tumor-like lesion. It results from compromised venous and lymphatic drainage due to partial or intermittent torsion of ovarian pedicle. Pain, distension or abdominal mass, menstrual irregularities, infertility and hormone-related symptoms can be the clinical presentation. We report a case of massive ovarian edema in a 28-year-old female who presented with acute pain abdomen. She was diagnosed clinico-radiologically with solid ovarian tumor and massive ovarian edema on histology...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29238287/survey-among-esge-members-on-leiomyosarcoma-morcellation-incidence
#19
Vasilios Tanos, Hans Brölmann, Rudi Leon DeWilde, Peter O'Donovan, Elina Symeonidou, Rudi Campo
Background: Increased awareness of leiomyosarcoma (LMS) risk during myomectomy or hysterectomy is essential. Objective and correct reasoning should prevail on any decision regarding the extent and type of surgery to employ. The anticipated risk of a sarcoma after myoma or uterus morcellation is low, and the frequency of leiomyosarcoma especially in women below the age of 40 is very rare. The prevalence data has a wide range and is therefore not reliable. The European Society of Gynaecological Endoscopy (ESGE) initiated a survey among its members looking into the frequency of morcellated leiomyosarcoma after endoscopic surgery...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29237379/male-urogen%C3%A4-tal-d%C3%A4-sorders-and-metabol%C3%A4-c-syndrome-poss%C3%A4-ble-l%C3%A4-nks-character%C3%A4-st%C3%A4-cs-and-potent%C3%A4-al-treatment-strateg%C3%A4-es
#20
Cetin Volkan Oztekin, Ecem Kaya, Didem Yilmaz-Oral, Serap Gur
BACKGROUND: Metabolic syndrome (MetS), as a cluster of metabolic derangements which is major risk factors for vascular disease, is one of the most important threats to public health. Although the epidemiological and limited amount of basic science and clinical evidence link MetS to several male urogenital disorders, a holistic approach aiming to define common mechanistic pathways and new possible therapeutic targets are lacking. OBJECTIVE: The current review has focused on providing scientific evidence on the role of MetS and its components on male urogenital disorders and the definition of new therapeutic targets...
December 12, 2017: Current Pharmaceutical Design
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