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https://www.readbyqxmd.com/read/29908376/the-increased-level-of-tspan5-in-villi-suggests-more-proliferation-and-invasiveness-of-trophoblasts-in-tubal-pregnancy
#1
Tianyang Gao, Yingqiu Liang, Haiyu Tang, Li Quan
OBJECTIVE: This study was to determinate the expression of Tspan5 in tubal ectopic implantation sites and to explore the correlation of the expressive level of Tspan5 at maternal-fetal interface and the occurrence of tubal ectopic pregnancy. STUDY DESIGN: This is a retrospective study. Trophoblastic and endometrial tissues were collected from tubal ectopic pregnancy(Total of 40), and intrauterine pregnancy(Total of 41), who had voluntary abortion, non-pregnancy women(Total of 12), who recieved an diagnostic uterine curettage before IVF-ET for male infertility...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29907856/deletion-of-ddb1-and-cul4-associated-factor-17-dcaf17-gene-causes-spermatogenesis-defects-and-male-infertility-in-mice
#2
Asmaa Ali, Bhavesh V Mistry, Hala A Ahmed, Razan Abdulla, Hassan A Amer, Abdelbary Prince, Anas M Alazami, Fowzan S Alkuraya, Abdullah Assiri
DDB1- and CUL4-associated factor 17 (Dcaf17) is a member of DCAF family genes that encode substrate receptor proteins for Cullin-RING E3 ubiquitin ligases, which play critical roles in many cellular processes. To unravel the function of DCAF17, we performed expression profiling of Dcaf17 in different tissues of wild type mouse by qRT-PCR and generated Dcaf17 knockout mice by gene targeting. Expression profiling of Dcaf17 showed highest expression in testis. Analyses of Dcaf17 transcripts during post-natal development of testis at different ages displayed gradual increase in Dcaf17 mRNA levels with the age...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907769/massive-expression-of-germ-cell-specific-genes-is-a-hallmark-of-cancer-and-a-potential-target-for-novel-treatment-development
#3
Jan Willem Bruggeman, Jan Koster, Paul Lodder, Sjoerd Repping, Geert Hamer
Cancer cells have been found to frequently express genes that are normally restricted to the testis, often referred to as cancer/testis (CT) antigens or genes. Because germ cell-specific antigens are not recognized as "self" by the innate immune system, CT-genes have previously been suggested as ideal candidate targets for cancer therapy. The use of CT-genes in cancer therapy has thus far been unsuccessful, most likely because their identification has relied on gene expression in whole testis, including the testicular somatic cells, precluding the detection of true germ cell-specific genes...
June 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29907661/nlrp3-in-somatic-non-immune-cells-of-rodent-and-primate-testes
#4
Lena Walenta, Nina Schmid, J U Schwarzer, Frank-Michael Köhn, Henryk Urbanski, Ruediger Behr, Leena Strauss, Matti Poutanen, Artur Mayerhofer
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohistochemistry. Sertoli cells of all species expressed NLRP3, and the expression preceded puberty. In addition, peritubular cells of the adult human testes expressed NLRP3. NLRP3 and associated genes (ASC, CASP1, IL1B) were also found in isolated human testicular peritubular cells (HTPCs) and the mouse Sertoli cell line TM4...
June 15, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29905822/endocervical-and-neutrophil-lipoxygenases-coordinate-neutrophil-transepithelial-migration-to-neisseria-gonorrhoeae
#5
Jacqueline S Stevens, Mary C Gray, Christophe Morisseau, Alison K Criss
Background: Infection with Neisseria gonorrhoeae (Ngo) is characterized by robust neutrophil influx that is insufficient to clear the bacteria. Sustained neutrophilic inflammation contributes to serious clinical sequelae that particularly affect women, including pelvic inflammatory disease and infertility. Methods: We established a three-component system using Ngo, End1 polarized human endocervical cells, and primary human neutrophils to investigate neutrophil transepithelial migration following infection...
June 13, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29905799/response-to-letter-to-the-editor-higher-tsh-levels-within-the-normal-range-are-associated-with-unexplained-infertility
#6
Pouneh K Fazeli, Hang Lee
No abstract text is available yet for this article.
June 13, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29905489/assisted-reproductive-technology-comorbidities-and-cardiovascular-risk-the-experience-of-an-italian-center
#7
Cinzia Fatini, Michela Cirillo, Maria Elisabetta Coccia
BACKGROUND: A growing number of infertile women undergo assisted reproductive technology (ART). Older maternal age and the presence of comorbidities may affect cardiovascular (CV) women health. Safety aspects are central in risk assessment; we report the experience of internal medicine clinical setting at the ART center. MATERIALS AND METHODS: we investigated 243 infertile women (110 autologous and 133 oocyte donation [OD]); cardiometabolic parameters and CV risk factors were investigated during the clinical evaluation...
June 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29904626/the-use-of-estrone-3-glucuronide-and-pregnanediol-3-glucuronide-excretion-rates-to-navigate-the-continuum-of-ovarian-activity
#8
REVIEW
Leonard F Blackwell, Delwyn G Cooke, Simon Brown
The patterns of a woman's normal ovarian activity can take many forms from childhood to menopause. These patterns lie on a continuum ranging from no ovarian activity to a fully fertile ovulatory cycle, but among the other defined patterns are cycles with anovulatory ovarian activity, including luteinized unruptured follicles (LUFs), and ovulatory cycles with deficient or short luteal phases. For any woman, these patterns can occur in any order, and one can merge into the next, without an intervening bleed, or be missed entirely...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29904401/analysis-on-the-association-between-sperm-dna-fragmentation-index-and-conventional-semen-parameters-blood-microelements-and-seminal-plasma-ros-in-male-patients-with-infertility
#9
Deng'e Xie, Chen Lu, Ying Zhu, Sulan Zhu, Er-Jiang Yang, Xin Jin
We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902815/feasibility-of-transabdominal-doppler-sonography-for-studying-uterine-blood-flow-characteristics-in-cycling-gilts
#10
Catherine Herlta, Rosa Starka, Haukur L Sigmarsson, Johannes Kauffold
OBJECTIVE: To test for the feasibility of transabdominal Doppler sonography (color, power, pulse wave) to define uterine perfusion characteristics throughout the estrous cycle in gilts. MATERIALS AND METHODS: A total of 15 gilts were synchronized for estrus and scanned in their following spontaneous cycle while being restrained in a purpose-designed mobile crate. To define uterine perfusion characteristics, vessels in between and within uterine cross-sections were imaged and recorded as video sequences to be analyzed by PixelFlux® software for perfused area (Amix), blood flow velocity (vmix) and intensity (Imix) as well as resistance (RIvmix) and pulsatility index (PIvmix)...
June 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29901590/effect-of-acupuncture-on-in-vitro-fertilization-an-updated-systematic-review-and-data-mining-protocol
#11
Xiaotong Wang, Haixiong Lin, Mingzhu Chen, Jian Wang, Yuanlin Jin
BACKGROUND: Although many patients try to seek acupuncture to improve in vitro fertilization (IVF) outcomes, evidence regarding its efficacy and acupoints characters are lacking. The aim of this protocol is to evaluate the effectiveness and safety, as well as the acupoints characteristics of acupuncture in the treatment of female undergoing IVF, by conducting a systematic review and data mining. METHODS: The following 6 databases will be searched from their inception to April 30, 2018: PubMed, Chinese National Knowledge Infrastructure, Wanfang, VIP database, Embase, and Cochrane Library...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901159/system-analysis-of-teratozoospermia-mrna-profile-based-on-integrated-bioinformatics-tools
#12
Tiancheng Zhang, Jun Wu, Caihua Liao, Zhong Ni, Jufen Zheng, Fudong Yu
mRNA has an important role in spermatogenesis and the maintenance of fertility, and may act as a potential biomarker for the clinical diagnosis of infertility. In the present study, potential biomarkers associated with teratozoospermia were screened through systemic bioinformatics analysis. Initially, genome‑wide expression profiles were downloaded from the Gene Expression Omnibus and primary analysis was conducted using R software, which included preprocessing of raw microarray data, transformation between probe ID and gene symbol and identification of differentially expressed genes...
May 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901132/inflammatory-cytokine-profile-of-co%C3%A2-cultivated-primary-cells-from-the-endometrium-of-women-with-and-without-endometriosis
#13
Adriana Luckow Invitti, Eduardo Schor, Rafael Martins Parreira, Alexander Kopelman, Gil Kamergorodsky, Giovana Aparecida Gonçalves, Manoel João Batista Castello Girão
Endometriosis is a chronic gynecological disorder defined as the presence of endometrial tissue within extra-uterine sites. The primary symptoms are infertility and chronic pain. The inflammatory environment and aberrant immune responses in women with endometriosis may be directly associated with the initiation and progression of endometriotic lesions. In the present study, the secretion of inflammatory cytokines was evaluated in cultures of primary endometrial cells (ECs) isolated from the endometrium of women with and without endometriosis...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900224/transcriptome-data-of-peripheral-white-blood-cells-from-beef-heifers-collected-at-the-time-of-artificial-insemination
#14
Sarah E Dickinson, Fernando H Biase
The reproductive performance of heifers within their first breeding season influences the success of beef cattle operations. Therefore, a means to identify infertile and late breeding heifers before the start of the breeding season holds great promise for the future of the beef industry. Pubertal beef heifers were subjected to estrous synchronization and fixed time artificial insemination (FTAI). We collected peripheral blood from the heifers at the time of artificial insemination (AI) and generated RNA sequencing data to characterize the transcriptome of peripheral white blood cells (PWBC)...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899387/childhood-cardiovascular-health-and-subfertility-the-bogalusa-heart-study
#15
Yiping Wang, Xu Xiong, Lydia Bazzano, Emily W Harville
BACKGROUND: Although childhood cardiovascular risk can contribute to adult cardiovascular disease, and fertility and adult cardiovascular health are linked, the association between early-life cardiovascular risk and female infertility has not been studied. METHODS: A total of 1799 women participated in the Babies substudy of the Bogalusa Heart Study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, and insulin were age-standardized and examined as predictors of self-reported fertility difficulties using multivariable logistic regression with adjustment for confounders...
June 13, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29899026/dominant-neuropeptide-co-transmission-in-kisspeptin-gaba-regulation-of-gnrh-neuron-firing-driving-ovulation
#16
Richard Piet, Bruna Kalil, Tim McLennan, Robert Porteous, Katja Czieselsky, Allan E Herbison
A population of kisspeptin-GABA co-expressing neurons located in the rostral periventricular area of the third ventricle (RP3V) is believed to activate gonadotropin-releasing hormone (GnRH) neurons to generate the luteinizing hormone (LH) surge triggering ovulation. Selective optogenetic activation of RP3V kisspeptin (RP3VKISS ) neurons in female mice for >30s and ≥10Hz in either a continuous or bursting mode was found to reliably generate a delayed and long-lasting activation of GnRH neuron firing in brain slices...
June 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29898709/depression-sexual-dysfunction-and-sexual-quality-of-life-in-women-with-infertility
#17
Zahra Shahraki, Fatemeh Davari Tanha, Mahsa Ghajarzadeh
BACKGROUND: Women suffering from infertility are at higher risk of experiencing psychological problems. Sexual function and sexual related quality of life is not considered as it should be. We designed this study to assess depression, sexual function and sexual quality of life in Iranian women with infertility. METHODS: Two hundred and sixty four individuals participated in the study (115 healthy controls, 78 with primary and 71 with secondary infertility). All participants were asked to fill a valid and reliable Persian versions of BDI (Beck depression inventory), FSFIS (Female Sexual Function Index) and sexual quality of life-Female (SQOL-F) questionnaires...
June 14, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29897878/model-construction-of-niemann-pick-type-c-disease-in-zebrafish
#18
Yusheng Lin, Xiaolian Caia, Guiping Wang, Gang Ouyang, Hong Cao
Niemann-Pick Type C disease (NPC) is a rare human disease, with limited effective treatment options. Most cases of NPC disease are associated with inactivating mutations of the NPC1 gene. However, cellular and molecular mechanisms responsible for the NPC1 pathogenesis remain poorly defined. This is partly due to the lack of a suitable animal model to monitor the disease progression. In this study, we used CRISPR to construct an NPC1-/- zebrafish model, which faithfully reproduced the cardinal pathological features of this disease...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29897458/increased-aif-1-mediated-tnf-%C3%AE-expression-during-implantation-phase-in-ivf-cycles-with-gnrh-antagonist-protocol
#19
Bufang Xu, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Feng Guo, Chenchen Si, Peter C K Leung, Aijun Zhang
STUDY QUESTION: Is allograft inflammatory factor-1 (AIF-1), a cytokine associated with inflammation and allograft rejection, aberrantly elevated in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone (GnRH) antagonist protocol with potential effects on endometrial receptivity? SUMMARY ANSWER: Our findings indicated AIF-1 is increased in IVF cycles with GnRH antagonist protocol and mediates greater TNF-α expression during implantation phase, which may be unfavorable for embryo implantation...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29897449/icsi-does-not-increase-the-cumulative-live-birth-rate-in-non-male-factor-infertility
#20
Z Li, A Y Wang, M Bowman, K Hammarberg, C Farquhar, L Johnson, N Safi, E A Sullivan
STUDY QUESTION: What is the cumulative live birth rate following ICSI cycles compared with IVF cycles for couples with non-male factor infertility? SUMMARY ANSWER: ICSI resulted in a similar cumulative live birth rate compared with IVF for couples with non-male factor infertility. WHAT IS KNOWN ALREADY: The ICSI procedure was developed for couples with male factor infertility. There has been an increased use of ICSI regardless of the cause of infertility...
June 12, 2018: Human Reproduction
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