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https://www.readbyqxmd.com/read/28742936/benefits-and-limitations-of-belatacept-in-4-hand-transplanted-patients
#1
J Grahammer, A Weissenbacher, B G Zelger, B Zelger, C Boesmueller, M Ninkovic, A Mühlbacher, I Peschel, G Brandacher, D Öfner, S Schneeberger
Belatacept (CTLA4Ig) is an emerging treatment in kidney transplantation. Lack of nephrotoxicity and possibly an inhibitory effect on the development of donor specific antibodies (DSA) make it an interesting agent in hand transplantation. In order to reduce CNI immunosuppression and preserve kidney function, we have added belatacept to the therapeutic regimen of 4 hand transplanted patients at month 4, at 6, 9, and 13 years after hand/forearm transplantation. Patients received 5mg/kg belatacept every 2 weeks, the dosing interval was extended to 4 weeks after 5 applications...
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28739521/effective-intraluminal-shunt-in-carotid-endarterectomy-for-carotid-artery-near-occlusion-a-technical-report
#2
Yoichiro Kawamura, Daisuke Maruyama, Yojiro Akagi, Koji Iihara
BACKGROUND: Carotid artery near occlusion is a critical degree of stenosis whereby blood flow is decreased and the distal cervical and intracranial internal carotid arteries (ICAs) are prone to collapse. Considering the diminished perfusion and the risk of progression to total occlusion and periocclusive embolism, we performed carotid endarterectomy (CEA) for carotid artery near occlusion. METHODS: Accurate evaluation of tandem stenosis or patency of the post-stenotic ICA in carotid artery near occlusion is often difficult preoperatively...
July 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735989/outcome-of-pretransplantation-therapeutic-plasma-exchange-in-highly-sensitized-deceased-donor-kidney-transplant-recipients
#3
P Tipjaiaue, A Ingsathit, P Kantachuvesiri, S Rattanasiri, D Thammanichanond, T Mongkolsuk, N Arpornsujaritkun, V Sumethkul, S Kantachuvesiri
BACKGROUND: Sensitization is associated with a high rate of post-transplantation rejection. A desensitization protocol using therapeutic plasma exchange (TPE) was proposed to reduce anti-HLA antibody before transplantation, but there has been limited data regarding the efficacy of pretransplantation TPE in highly sensitized deceased-donor kidney transplantation (DDKT). METHODS: A retrospective cohort study of 142 patients who received DDKT was conducted and divided into two groups: a high-panel-reactive antibody (PRA) >50% group and a low-PRA ≤50% group...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28734583/kidney-transplantation-from-hla-incompatible-live-donors-efficiency-and-outcome-of-32-patients-after-desensitisation
#4
Constantino Fernández, María Calvo, Natacha Leite, Andrés López, Tamara Ferreiro, Roi Ribera, Rocío Seijo, Ángel Alonso
Desensitisation is a procedure undergone by the recipient of a kidney transplant from a donor who is cross-match positive. The aim of this study was to present the outcomes from our hospital of kidney transplant recipients from HLA-incompatible live donors after desensitisation. We studied 32 patients aged 46±14 years with a mean fluorescence intensity (MFI) versus class I HLA of 7979±4089 and 6825±4182 MFI versus class II and relative intensity scale (RIS) of 8.9±7.6. The complement-dependent cytotoxicity (CDC) cross-matching test was positive in 18 patients, flow cytometry was positive in 7 patients and donor-specific antibodies (DEA) were detected in 7...
July 19, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28732720/impact-on-mid-term-kidney-graft-outcomes-of-pretransplant-anti-hla-antibodies-detected-by-solid-phase-assays-do-donor-specific-antibodies-tell-the-whole-story
#5
Jorge Malheiro, Sandra Tafulo, Leonídio Dias, La Salete Martins, Isabel Fonseca, Idalina Beirão, António Castro-Henriques, António Cabrita
The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant sera by solid-phase assays. NDSA or DSA were detected in 100 (13.8%) and 47 (6.5%) recipients respectively, while 577 (79.7%) were non-allosensitized (NaS). Incidence of antibody-mediated rejection at 1-year was 0...
July 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28731902/terasaki-epitope-mismatch-burden-predicts-the-development-of-de-novo-dq-donor-specific-antibodies-and-are-associated-with-adverse-allograft-outcomes
#6
Michelle Willicombe, Matthew Blow, Eva Santos-Nunez, Corinna Freeman, Paul Brookes, David Taube
BACKGROUND: De novo DQ DSA are associated with antibody-mediated rejection and allograft loss. Given the lack of effective treatment of de novo DQ DSA, their prevention is vital if there is to be an improvement of long term allograft survival. Using the HLA Matchmaker programme, DQ epitope matching has been shown to be superior to HLA antigen mismatching in predicting de novo DQ DSA development. Whether DQ epitopes determined by Terasaki may more accurately predict de novo DQ development over HLA antigen matching is not known...
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28728535/endovascular-occlusion-of-pial-arteriovenous-macrofistulae-using-pcanvas1-and-adenosine-induced-asystole-to-control-nbca-injection
#7
P Lylyk, J Chudyk, C Bleise, C Serna Candel, M Aguilar Pérez, H Henkes
Background In large-caliber pial macrofistulae (pMF), the combination of high blood flow velocity and large efferent artery diameter makes control over the endovascular vessel occlusion difficult and may result in the inadvertent venous passage of occlusive devices or embolic agents. Case descriptions Patient 1: A 27-year-old man presented with headache and ataxia. An infratentorial pMF supplied by both superior cerebellar arteries with venous ectasia was found. The first treatment attempt using balloons and coils failed since the position of either device could not be controlled because of a distal diameter of the feeding artery of 8 mm...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28726223/comprehensive-study-on-parameter-sensitivity-for-flow-and-nutrient-modeling-in-the-hydrological-simulation-program-fortran-model
#8
Chuan Luo, Zhaofu Li, Min Wu, Kaixia Jiang, Xiaomin Chen, Hengpeng Li
Numerous parameters are used to construct the HSPF (Hydrological Simulation Program Fortran) model, which results in significant difficulty in calibrating the model. Parameter sensitivity analysis is an efficient method to identify important model parameters. Through this method, a model's calibration process can be simplified on the basis of understanding the model's structure. This study investigated the sensitivity of the flow and nutrient parameters of HSPF using the DSA (differential sensitivity analysis) method in the Xitiaoxi watershed, China...
July 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28724339/influence-of-cerebrovascular-reactivity-on-outcome-of-the-patients-with-%C3%A2-50-symptomatic-unilateral-middle-cerebral-artery-stenosis
#9
Weiqing Zhang, Yanwei Yin, Yingqian Zhang, Fen Yang, Wenqian Shi, Dawei Chen, Chen Song, Huiping Shi, Xuanzhu Zhao, Jin Shi
Cerebrovascular reactivity (CVR) reflects the vasodilatory reserve of cerebral resistance vessels, which is an important marker for assessing cerebrovascular disease. The present study is to investigate whether CVR impairment increases adverse long-term outcome risk of patients with ≥ 50% symptomatic unilateral middle cerebral artery (MCA) stenosis (ischemic stroke (IS) or transient ischemic attack (TIA)). Digital subtraction angiography (DSA) was used to assess the degree of stenosis, and perfusion CT and 5% CO2 inhalation were adopted to evaluate CVR...
July 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28723698/application-technical-issues-and-interpretation-of-c1q-for-graft-outcome
#10
Dolly B Tyan
PURPOSE OF REVIEW: Significant interest and controversy surround the use of C1q for determining risk of antibody-mediated rejection (AMR) and graft loss. Alternate models for predicting outcomes have been proposed. This review focuses on the correlation of currently utilized assays for outcome, together with the technical and theoretical limitations, to distill current thinking. RECENT FINDINGS: Results demonstrate that C1q status is significantly correlated with AMR and graft loss...
July 18, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28722300/digital-subtraction-angiography-dynavision-in-pretreatment-planning-for-embolization-of-dural-arterio-venous-fistulas
#11
Alex Botsford, Jai Jai Shiva Shankar
BACKGROUND AND PURPOSE: We have found DSA-Dynavision with multiplanar reconstruction very helpful in understanding the complex anatomy and planning of treatment of carotico-cavernous fistulas. The purpose of our study was to examine whether using DSA-Dynavision in pretreatment planning results in better outcome after endovascular treatment of dural arterio-venous fistulas (dAVFs). METHODS: Patients with dAVF treated with endovascular embolization were retrospectively identified from our interventional neuroradiology database...
July 19, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28716257/associations-between-white-matter-hyperintensities-and-cognitive-decline-over-three-years-in-non-dementia-older-adults-with-memory-complaints
#12
So Young Moon, Philipe de Souto Barreto, Marie Chupin, Jean François Mangin, Ali Bouyahia, Ludovic Fillon, Sandrine Andrieu, Bruno Vellas
We investigated whether the baseline level and overtime changes of white matter hyperintensities (WMH) would be associated with cognitive decline over three years in non-demented older adults with memory complaints. 109 participants with baseline magnetic resonance imaging (MRI) and follow-up cognitive assessments up to 3-year were included; among them, 82 also had a follow-up MRI assessment over three years. WMH volume was obtained by an automated segmentation algorithm. Baseline WMH volumes and change between baseline and follow-up WMH were related to cognitive scores over time using mixed-effect linear regressions...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714668/self-registered-self-assembly-of-block-copolymers
#13
Lei Wan, Ricardo Ruiz, He Gao, Thomas R Albrecht
Directed self-assembly (DSA) of block copolymer (BCP) thin films, especially with density multiplication, is one of the most promising options for further improving resolution and throughput in nanolithography. However, controlling defect density has been one of the major hurdles for many DSA applications. Both thermodynamically and kinetically, defect-free patterns favor the use of low density multiplication factors and thinner films, which undermine the promise of enhanced resolution and the formation of robust masks for pattern transfer...
July 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28712148/influence-of-kidney-offer-acceptance-behavior-on-metrics-of-allocation-efficiency
#14
Andrew Wey, Nicholas Salkowski, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
We investigated associations of deceased donor kidney offer acceptance with likelihood of the kidney being discarded, cold ischemia time at transplant (CIT), and likelihood of the kidney being exported outside the donation service area (DSA). We used kidney offers from donors in the Scientific Registry of Transplant Recipients July 1, 2015-June 30, 2016, and a stratified logistic regression to estimate odds ratios of acceptance for candidates waitlisted in a DSA. We estimated associations between these ratios and likelihood of discard or export and CIT at transplant...
July 16, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28712132/impact-of-lipoprotein-apheresis-with-dextran-sulfate-adsorption-on-the-expression-of-genes-involved-in-cardiovascular-health-in-the-blood-of-patients-with-homozygous-familial-hypercholesterolemia
#15
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean Bergeron, Nathalie Laflamme, Benoît Lamarche, Patrick Couture
Lipoprotein apheresis (LA) with dextran sulfate adsorption (DSA) is a reliable method to decrease LDL-cholesterol (C) concentrations in patients with homozygous familial hypercholesterolemia (HoFH). The objective of the present study was to investigate the impact of LA with DSA on the mRNA expression of genes associated with cardiovascular health in the whole blood of HoFH patients. Blood samples were collected before and after LA treatment with DSA in 9 HoFH patients. Microarray analyses were performed to measure the whole blood expression of >30 000 annotated genes pre- and post-LA...
July 16, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28709428/a-systematic-comparison-of-statistical-methods-to-detect-interactions-in-exposome-health-associations
#16
Jose Barrera-Gómez, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Lise Giorgis-Allemand, Valérie Siroux, Oliver Robinson, Jelle Vlaanderen, Juan R González, Mark Nieuwenhuijsen, Paolo Vineis, Martine Vrijheid, Roel Vermeulen, Rémy Slama, Xavier Basagaña
BACKGROUND: There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human environmental exposures from conception onwards). Uncovering such combined effects is challenging owing to the large number of exposures, several of them being highly correlated. We performed a simulation study in an exposome context to compare the performance of several statistical methods that have been proposed to detect statistical interactions...
July 14, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28708813/application-and-interpretation-of-histocompatibility-data-in-liver-transplantation
#17
Russell N Wesson, Eric W Etchill, Jacqueline Garonzik-Wang
PURPOSE OF REVIEW: There has been a resurgence of interest in histocompatibility as it applies to liver transplantation. The association of persistent and de-novo donor specific antibody (DSA) and outcomes after liver transplantation continues to be investigated. RECENT FINDINGS: Consensus continues to evolve regarding the existence of acute and chronic antibody-mediated rejection (AMR) and pathogenicity of DSA and associated pathologic findings after liver transplantation...
July 13, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28707544/differentiation-of-chronic-total-occlusion-and-sub-total-occlusion-of-the-femoropopliteal-artery-role-of-retrograde-flow-sign-and-collateral-circulation-on-ct-angiography-images
#18
Shujun Zhang, Yanfei Su, Haisong Chen
OBJECTIVE: To study the value of a retrograde flow sign and the collateral circulation on computed tomography angiography (CTA) for the differential diagnosis of chronic total occlusion from sub-total occlusion of the femoropopliteal artery (FPA). METHODS: Fifty patients with obstruction of the FPA underwent CTA and digital subtraction angiography (DSA) examinations of the lower limbs. The frequency of a retrograde flow sign and collateral circulation on CTA in chronic total and sub-total occlusion was noted and analyzed, with the results of DSA as a standard to judge total or sub-total occlusion...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28707434/utility-of-digital-subtraction-angiography-based-collateral-evaluation-in-medically-treated-acute-symptomatic-basilar-artery-stenosis
#19
W-J Lee, K-H Jung, Y J Ryu, J-M Kim, S-T Lee, K Chu, M Kim, S K Lee, J-K Roh
BACKGROUND AND PURPOSE: Although a stroke from atherosclerosis in the basilar artery (BA) often presents with mild initial stroke severity, it has heterogeneous clinical courses. We investigated the efficacy of digital subtraction angiography (DSA)-based collateral perfusion evaluation in association with long-term outcomes of medically treated symptomatic basilar artery stenosis. METHODS: From a registry database of all consecutive patients with stroke, we included 98 medically treated patients (due to mild initial stroke severity) [National Institute of Health Stroke Scale (NIHSS) scores ≤ 4; symptomatic basilar artery stenosis, 70-99%] with available initial diagnostic DSA...
July 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28707187/imaging-in-vascular-access
#20
Eoin A Murphy, Rose A Ross, Robert G Jones, Stephen J Gandy, Nicolas Aristokleous, Marco Salsano, Jonathan R Weir-McCall, Shona Matthew, John Graeme Houston
This review examines four imaging modalities; ultrasound (US), digital subtraction angiography (DSA), magnetic resonance imaging (MRI) and computed tomography (CT), that have common or potential applications in vascular access (VA). The four modalities are reviewed under their primary uses, techniques, advantages and disadvantages, and future directions that are specific to VA. Currently, US is the most commonly used modality in VA because it is cheaper (relative to other modalities), accessible, non-ionising, and does not require the use of contrast agents...
July 13, 2017: Cardiovascular Engineering and Technology
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