Tomohiro Katsuya, Yoshito Inobe, Kazuaki Uchiyama, Tetsuo Nishikawa, Kunio Hirano, Mitsutoshi Kato, Toshiki Fukui, Tsuguru Hatta, Arata Iwasaki, Hajime Ishii, Toshiyuki Sugiura, Takashi Taguchi, Ayumi Tanabe, Kotaro Sugimoto, Tatsuo Shimosawa
Excessive salt intake is one of the causes of hypertension, and reducing salt intake is important for managing the risk of hypertension and subsequent cardiovascular events. Esaxerenone, a mineralocorticoid receptor blocker, has the potential to exert an antihypertensive effect in hypertensive patients with excessive salt intake, but evidence is still lacking, especially in clinical settings. We aimed to determine if baseline sodium/potassium ratio and baseline estimated 24-h urinary sodium excretion can predict the antihypertensive effect of esaxerenone in patients with essential hypertension inadequately controlled with an angiotensin receptor blocker (ARB) or a calcium channel blocker (CCB)...
January 11, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension