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https://www.readbyqxmd.com/read/27913812/association-between-cytokines-and-their-receptor-antagonist-gene-polymorphisms-and-clinical-risk-factors-and-acute-rejection-following-renal-transplantation
#1
SIqing Ding, Jianfei Xie, Qiquan Wan
BACKGROUND Acute rejection (AR) after renal transplantation affects both patient and graft survival. There is growing evidence of the genetic association between cytokine or its receptor antagonist and AR in solid organ transplantation. The objectives of this study were to investigate the role of recipient TNF β, IL-10, IL-1β, and IL-1 receptor antagonist (ra) gene polymorphism, as well as traditional clinical variables such as panel-reactive antibody (PRA) levels, donor type, and HLA mismatches in AR following renal transplantation...
December 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27904103/plasma-renin-activity-predicts-the-improvement-in-resistant-hypertension-after-percutaneous-transluminal-renal-artery-angioplasty
#2
Hyuma Daidoji, Yoshiaki Tamada, Saya Suzuki, Ken Watanabe, Taku Shikama, Yoku Kikuchi, Shigehiko Kato, Katsuaki Takahashi, Akio Fukui, Motoyuki Matsui, Tomoyasu Yahagi, Toshikazu Goto
Objective Percutaneous transluminal renal artery angioplasty (PTRA) has been recommended for the treatment of renovascular resistant hypertension. However, large randomized trials have reported that PTRA did not improve the outcomes compared with optimal medical therapy in patients with renal artery stenosis (RAS). It is important to identify patients with renovascular hypertension who are likely to respond to PTRA. We herein examined whether or not the plasma renin activity (PRA) could predict the improvement in resistant hypertension after PTRA for RAS...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27898477/costs-and-length-of-stay-for-the-acute-care-of-patients-with-motor-complete-spinal-cord-injury-following-cervical-trauma-the-impact-of-early-transfer-to-specialized-acute-sci-center
#3
Andréane Richard-Denis, Debbie Ehrmann Feldman, Cynthia Thompson, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong
OBJECTIVE: Acute spinal cord injury (SCI) centers aim to optimize outcome following SCI. However, there is no timeframe to transfer patients from regional to SCI centers in order to promote cost-efficiency of acute care. Our objective was to compare costs and length of stay (LOS) following early and late transfer to the SCI center. DESIGN: A retrospective cohort study involving 116 individuals was conducted. Group 1 (n = 87) was managed in an SCI center promptly after the trauma, whereas group 2 (n = 29) was transferred to the SCI center only after surgery...
November 24, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27896899/characterization-of-a-novel-form-of-progressive-retinal-atrophy-in-whippet-dogs-a-clinical-electroretinographic-and-breeding-study
#4
André Tavares Somma, Juan Carlos Duque Moreno, Mario Teruo Sato, Blanche Dreher Rodrigues, Marianna Bacellar-Galdino, Laurence Mireille Occelli, Simon Michael Petersen-Jones, Fabiano Montiani-Ferreira
OBJECTIVE: To describe a form of progressive retinal atrophy (PRA) in Whippets including clinical, electroretinographic, optical coherence tomographic changes and pedigree analysis. ANIMALS STUDIED: Client-owned Whippet dogs (n = 51) living in Brazil. PROCEDURES: All animals were submitted for routine ophthalmic screening for presumed inherited ocular disease, which included the following: visual tests, such as obstacle course tests, in scotopic and photopic conditions, cotton ball test, dazzle reflex, ocular fundus evaluation by indirect ophthalmoscopy followed by fundus photography...
November 29, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27893293/prevelence-of-primary-aldosteronism-in-an-urban-hypertensive-population
#5
Sandi-Jo Galati, Khadeen C Cheesman, Ryan Springer-Miller, Sarah M Hopkins, Lawrence Krakoff, Emilia Bagiella, Rachel A Zhuk, Tiffany K Ying, Chelsey Amer, Michael K Boyajian, W B Inabnet, Alice C Levine
OBJECTIVE: To determine the prevalence of primary aldosteronism (PA) in hypertensive patients presenting to the primary care clinic at The Mount Sinai Hospital, regardless of the degree of hypertension and to identify clinical criteria that should prompt screening for PA. METHODS: An aldosterone:renin ratio (ARR, cutoff ≥20, with plasma aldosterone concentration [PAC] ≥10 and suppressed renin) was used to prospectively screen 296 hypertensive patients (blood pressure [BP] ≥140/90) over the age of 18 from August 2012 through May 2013...
November 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27888343/laparoscopic-anterior-versus-endoscopic-posterior-approach-for-adrenalectomy-a-shift-to-a-new-golden-standard
#6
O M Vrielink, K P Wevers, J W Kist, I H M Borel Rinkes, P H J Hemmer, M R Vriens, J de Vries, S Kruijff
PURPOSE: There has been an increased utilization of the posterior retroperitoneal approach (PRA) for adrenalectomy alongside the "classic" laparoscopic transabdominal technique (LTA). The aim of this study was to compare both procedures based on outcome variables at various ranges of tumor size. METHODS: A retrospective analysis was performed on 204 laparoscopic transabdominal (UMC Groningen) and 57 retroperitoneal (UMC Utrecht) adrenalectomies between 1998 and 2013...
November 26, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27887832/perfluoroalkyl-acids-pfaas-in-the-pra-and-kakum-river-basins-and-associated-tap-water-in-ghana
#7
David K Essumang, Albert Eshun, Jonathan N Hogarh, John K Bentum, Joseph K Adjei, Junya Negishi, Shihori Nakamichi, Md Habibullah-Al-Mamun, Shigeki Masunaga
Perfluoroalkyl acids (PFAAs) are persistent environmental pollutants that have been detected in various media including human serum. Due to concerns regarding their bioaccumulation and possible negative health effects, an understanding of routes of human exposure is necessary. PFAAs are recalcitrant in many water treatment processes, making drinking water a potential source of human exposure. This study presents the first report on contamination from PFAAs in river and drinking water in Ghana. The targeted PFAAs were perfluoroalkyl carboxylic acids (PFCAs) with C4-14 carbon chain and perfluoroalkane sulphonic acids (PFSAs) with C6, 8, 10...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27883212/a-retrospective-study-on-periodontal-disease-progression-in-private-practice
#8
Luigi Nibali, Chuanming Sun, Aliye Akcalı, Xsuan Meng, Yu-Kang Tu, Nikos Donos
BACKGROUND: Only a handful of studies have assessed tooth loss risk in chronic periodontitis patients following active therapy and factors associated with it. AIMS: The aim of this retrospective study was to assess tooth loss in a cohort of chronic periodontitis patients undergoing maintenance care in a UK private practice setting. MATERIALS AND METHODS: One hundred chronic periodontitis patients treated with active periodontal therapy (APT) were followed up in supportive periodontal therapy (SPT) for at least 5 years...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27882322/identification-of-species-of-nontuberculous-mycobacteria-clinical-isolates-from-8-provinces-of-china
#9
Haican Liu, Lulu Lian, Yi Jiang, Mingxiang Huang, Yunhong Tan, Xiuqin Zhao, Jingrui Zhang, Qin Yu, Jiao Liu, Haiyan Dong, Bing Lu, Yimou Wu, Kanglin Wan
Pulmonary diseases caused by nontuberculous mycobacteria (NTM) are increasing in incidence and prevalence worldwide. In this study, we identified NTM species of the clinical isolates from 8 provinces in China, in order to preliminarily provide some basic scientific data in the different species and distribution of NTM related to pulmonary disease in China. A total of 523 clinical isolates from patients with tuberculosis (TB) diagnosed clinically from 2005 to 2012 were identified to the species using conventional and molecular methods, including multilocus PCR, rpoB and hsp65 PCR-PRA, hsp65, rpoB, and 16S-23S internal transcribed spacer region sequencing...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27876532/efficacy-of-the-c-terminal-telopeptide-test-in-predicting-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaw-a-systematic-review
#10
REVIEW
K J Dal Prá, C A A Lemos, R Okamoto, A M P Soubhia, E P Pellizzer
This systematic review evaluated the efficacy of the morning fasting serum C-terminal telopeptide (CTX) test in predicting the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). A comprehensive search of studies published up to March 2016, and listed in the PubMed/MEDLINE, Web of Science, and Cochrane Library databases, was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This review has been registered in the PROSPERO international prospective register of systematic reviews (CRD42016036717)...
November 19, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27866332/decreased-proteinase-a-excretion-by-strengthening-its-vacuolar-sorting-and-weakening-its-constitutive-secretion-in-saccharomyces-cerevisiae
#11
Yefu Chen, Lulu Song, Yueran Han, Mingming Liu, Rui Gong, Weiwei Luo, Xuewu Guo, Dongguang Xiao
Proteinase A (PrA), encoded by PEP4 gene, is detrimental to beer foam stability. There are two transport pathways for the new synthesized PrA in yeast, sorting to the vacuole normally, or excreting out of the cells under stress conditions. They were designated as the Golgi-to-vacuole pathway and the constitutive secretory pathway, respectively. To reduce PrA excretion in some new way instead of its coding gene deletion, which had a negative effect on cell metabolism and beer fermentation, we modified the PrA transport based on these above two pathways...
November 19, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27864110/antinociceptive-activity-and-mechanism-of-action-of-hydroalcoholic-extract-and-dichloromethane-fraction-of-amphilophium-crucigerum-seeds-in-mice
#12
Samira Dal Toé De Prá, Paula Ronsani Ferro, Alessandra Marcon Milioli, Flávia Karine Rigo, Orlando Justo Chipindo, Camila Camponogara, Rosana Casoti, Melânia Palermo Manfron, Sara Marchesan de Oliveira, Juliano Ferreira, Gabriela Trevisan
ETHNOPHARMACOLOGICAL RELEVANCE: The medicinal plant generally known as monkey's comb (Amphilophium crucigerum) has been popularly described for the treatment of neuropathic and inflammatory pain, specially seeds preparations. AIM OF THE STUDY: The goal of the present study was to evaluate the antinociceptive effect of the crude extract (Crd) and dichloromethane fraction (Dcm) of A. crucigerum seeds, and investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptor in this effect...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27843626/tumour-and-cellular-distribution-of-activated-forms-of-pr-in-breast-cancers-a-novel-immunohistochemical-analysis-of-a-large-clinical-cohort
#13
Jacques Bonneterre, Jacques Bosq, Philippe Jamme, Alexander Valent, Erard M Gilles, Alexander A Zukiwski, Suzanne A W Fuqua, Carol A Lange, Joyce O'Shaughnessy
BACKGROUND: The progesterone receptor (PR) is expressed by ∼70% of early breast tumours and is implicated in the progression of breast cancer. In cancerous tissues PR may be activated in the absence of a ligand, or when ligand concentrations are very low, resulting in aberrantly activated PR (APR). The presence of APR may indicate that patients with breast cancer are more likely to respond to antiprogestins. The aims of this study were to describe and classify the histological subnuclear morphology of active and inactive PR in archival breast cancer samples...
2016: ESMO Open
https://www.readbyqxmd.com/read/27830672/an-approach-to-complicated-diverticular-disease-a-retrospective-study-in-an-acute-care-surgery-service-recently-established
#14
Savino Occhionorelli, Monica Zese, Daniela Tartarini, Domenica Lacavalla, Stefano Maccatrozzo, Giacomo Groppo, Maria Grazia Sibilla, Rocco Stano, Lorenzo Cappellari, Giorgio Vasquez
AIM: Acute diverticulitis is a frequent disease in the Western Countries. The increase number of patients admitted in the Surgery Departments led the necessity of new Scores and Classifications in order to clarify, in absence of clear guidelines, the best treatments to offer in the different situations. METHODS: A retrospective study of ninety-nine patients treated in our Department from June 2010 and March 2015. RESULTS: In our study 41 patients were treated conservatively, the remaining 58 were operated, 56 laparotomic and 2 laparoscopic...
October 10, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27822397/management-of-stable-angina-with-ivabradine-as-safe-alternative-to-patients-with-myasthenia-gravis
#15
Giuliano Ohde Dalledone, Gustavo Lenci Marques, Renata Dal-Prá Ducci, Arnaldo Laffitte Stier Junior, Cláudia Suemi Kamoi Kay, Lineu Cesar Werneck, Paulo José Lorenzoni, Rosana Herminia Scola
Management of cardiac symptoms in myasthenia gravis (MG) patients can be challenging. The aim of this report is to describe the safe use of ivabradine for stable angina in MG patients. A 48 y.o. woman, with MG diagnosis, presented stable angina. Therapies choices were reduced considering concomitant disease as well as previous and unsuccessful cardiologic managements. Ivabradine showed unexpected results. The patient presented an improvement of neurological and cardiac symptoms, bringing ivabradine as one more therapeutic option to similar patients...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27815151/right-atrial-pressure-in-the-critically-ill-how-to-measure-what-is-the-value-what-are-the-limitations
#16
REVIEW
Sheldon Magder
Right atrial pressure (Pra) is determined by the interaction of the function of the heart as a pump, called cardiac function, and the factors that determine the return of blood to heart, called return function. Thus, monitoring Pra or its surrogate, central venous pressure (CVP), can give important insights into mechanisms behind changes in hemodynamic status, responses to interventions, and the likelihood of diagnoses. Examination of the components of the Pra tracing, especially during the ventilator cycle, also can give information about right heart diastolic function, status of the tricuspid valve, volume responsiveness and the cardiac rhythm...
November 1, 2016: Chest
https://www.readbyqxmd.com/read/27793856/prediction-of-hemodynamics-under-left-ventricular-assist-device
#17
Takamori Kakino, Keita Saku, Takafumi Sakamoto, Kazuo Sakamoto, Takuya Akashi, Masataka Ikeda, Tomomi Ide, Takuya Kishi, Hiroyuki Tsutsui, Kenji Sunagawa
Left ventricular assist device (LVAD) saves lives in patients with severe left ventricular (LV) failure. However, predicting how much LVAD boosts total cardiac output (CO) remains difficult. This study aimed to develop a framework to quantitatively predict the impact of LVAD on hemodynamics. We adopted the circulatory equilibrium framework and incorporated LVAD into the integrated CO curve to derive the circulatory equilibrium. In anesthetized dogs, we ligated left coronary arteries to create LV failure and inserted a centrifugal pump as LVAD...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27783263/hla-typing-analysis-following-allogeneic-bone-grafting-for-sinus-lifting
#18
Marcelo Piaia, Carolina Bonet Bub, Guilherme de Menezes Succi, Margareth Torres, Thiago Henrique Costa, Fabricio Costa Pinheiro, Marcelo Henrique Napimoga
According to the Brazilian Association of Organ Transplants, in 2015, 19,408 bone transplants were performed in Brazil, over 90% by Dental Surgeons. The surgical technique itself has a respectable number of reports regarding its clinical efficacy, as measured by long-term survival of dental implants in grafted areas. Uncertainty remains, however, as to whether fresh frozen grafts from human bone donors remain immunologically innocuous in the body of the host. Six male with no previous medical history of note, including systemic diseases, surgery or blood transfusion were selected...
October 25, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27779488/venous-thromboembolism-as-predictor-of-acute-care-hospital-transfer-and-inpatient-rehabilitation-length-of-stay
#19
Shanti M Pinto, Gary Galang
OBJECTIVE: The aim of this study was to investigate the impact of venous thromboembolism (VTE) on rate of acute care hospital transfer, inpatient rehabilitation (IPR) length of stay (LOS), and functional outcomes. DESIGN: This was a retrospective cohort study of 2312 consecutive patient discharges from a single IPR facility over an 18-month period. RESULTS: When age, sex, reason for admission, and admission Functional Independence Measure (FIM) scores were controlled for, those with VTE had nearly 2 times greater odds for transfer to acute care hospital than did those without a diagnosis of VTE...
October 22, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27770524/assosiation-of-endogenous-cardiotonic-steroids-with-salt-sensitivity-of-blood-pressure-in-georgian-population
#20
N Kantaria, I Pantsulaia, I Andronikashvili, G Simonia
This investigation differentiates types of essential hypertension in a Georgian population as well as describes endogenous cardiotonic steroids in salt-sensitive and salt-resistant subjects. This case control study included 185 subjects: 94 cases with stage 1 essential hypertension (JNC7) naïve to antihypertensive treatment, and 91 controls. A salt-sensitivity test was used to dichotomize case and control groups into salt-sensitive and salt-resistant subgroups. Blood and urine samples were obtained to categorize participants as consuming high and low salt diets...
September 2016: Georgian Medical News
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