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https://www.readbyqxmd.com/read/29040714/nice-issues-positive-recommendation-for-xeljanz%C3%A2-%C3%A2-tofacitinib-citrate-as-a-new-treatment-option-for-adults-with-severe-rheumatoid-arthritis
#1
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/29040148/long-term-effects-of-bone-morphogenetic-protein-2-loaded-calcium-phosphate-on-maxillary-sinus-lift-surgery-for-delayed-and-simultaneous-dental-implantation
#2
Yuefeng Ding, Xuejuan Wang
Maxillary sinus lift surgery (MSLS) is considered to be a useful treatment method for patients with atrophic alveolar bone. Choosing a suitable surgical procedure to simultaneously decrease graft absorption and obtain long-term survival of dental implants is still a challenge. In this study, 20 patients received MSLS with graft of bone morphogenetic protein 2 (BMP2)-loaded calcium phosphate. Dental implants were placed simultaneously in 10 patients receiving MSLS (1-stage group), and in 10 patients receiving dental implants with a 3 to 6 months delay (2-stage group)...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29034296/diagnosis-of-asthma-in-symptomatic-children-based-on-measures-of-lung-function-an-analysis-of-data-from-a-population-based-birth-cohort-study
#3
Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson
BACKGROUND: Concerns have been expressed about asthma overdiagnosis. The UK National Institute of Health and Care Excellence (NICE) proposed a new diagnostic algorithm applying four lung function measures sequentially (ratio of forced expiratory volume in 1 s [FEV1] to forced vital capacity [FVC] <70%, bronchodilator reversibility ≥12%, fractional exhaled nitric oxide [FeNO] ≥35 parts per billion, and peak expiratory flow variability >20%). We aimed to assess the diagnostic value of three of the tests individually, and then test the proposed algorithm in symptomatic children...
October 2017: Lancet Child Adolesc Health
https://www.readbyqxmd.com/read/29034094/antibiotic-therapy-supportive-treatment-and-management-of-immunomodulation-inflammation-response-in-community-acquired-pneumonia-review-of-recommendations
#4
REVIEW
Marco Mantero, Paolo Tarsia, Andrea Gramegna, Sonia Henchi, Nicolò Vanoni, Marta Di Pasquale
Community-acquired pneumonia is a common and serious disease, with high rates of morbidity and mortality. Management and treatment of community-acquired pneumonia are described in three main documents: the 2007 American Thoracic Society guidelines, the 2011 European Respiratory Society guidelines, and the 2009 British Thoracic Society guidelines, updated by the NICE in 2015. Despite the validity of current guidelines in improving prognosis and management of patients with community-acquired pneumonia, not all recommendations have high levels of evidence and there are still some controversial issues...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29033308/2017-annual-meeting-of-the-american-college-of-radiology-moreton-lecture-forecasting-the-futures-of-radiology
#5
Jeffrey C Bauer
PURPOSE: The traditional forces of change in health care are no longer working as they did in the past. Political gridlock has destroyed Washington's ability to create sensible policy for reforming the medical marketplace, creating chaos for providers. Fortunately, chaos creates opportunity. The idea of creating one's future has never been more relevant and necessary. MATERIALS AND METHODS: Predicting-the science of extrapolating future values from historical data-is not a valid method for looking ahead when causal relationships that explained change in the past are themselves being redefined (the current situation)...
October 13, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29032084/facile-synthesis-of-low-cost-magnetic-biosorbent-from-peach-gum-polysaccharide-for-selective-and-efficient-removal-of-cationic-dyes
#6
Chan Li, Xuejing Wang, Duye Meng, Li Zhou
Magnetic biosorbents derived from renewable resource are emerging as a new class of adsorbing material for environmental cleanup because of their eco-friendly characteristic, easy availability and low cost. Herein, a novel magnetic peach gum bead (MPGB) biosorbent was successfully fabricated by a simple one-step reaction based on the simultaneous formation of magnetic nanoparticles and cross-linking of natural peach gum polysaccharide. Benefiting from the combined merits of peach gum and magnetic nanoparticles, the MPGB not only showed excellent adsorption performance for cationic dyes but also exhibited convenient magnetic separation capability...
October 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29031824/the-exeter-trauma-stem-a-radiographic-follow-up-at-minimum-of-five-years-post-implantation
#7
A M Kassam, L Tillotson, S L Whitehouse, J Charity
INTRODUCTION: The Exeter Trauma Stem (ETS) has been recommended by National Institute of Clinical Excellence (NICE) guidelines in the United Kingdom as a proven, cemented stem. A single laboratory study in the literature has raised possible concerns about the polished finish of the ETS and subsequent potential for accelerated loosening although there is little clinical evidence to support or refute this. METHODS: The aim of this study was to assess clinical outcomes of the ETS at a minimum of five years post implantation...
October 7, 2017: Injury
https://www.readbyqxmd.com/read/29031786/differentiation-and-protective-capacity-of-virus-specific-cd8-t-cells-suggest-murine-norovirus-persistence-in-an-immune-privileged-enteric-niche
#8
Vesselin T Tomov, Olesya Palko, Chi Wai Lau, Ajinkya Pattekar, Yuhang Sun, Ralitza Tacheva, Bertram Bengsch, Sasikanth Manne, Gabriela L Cosma, Laurence C Eisenlohr, Timothy J Nice, Herbert W Virgin, E John Wherry
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic infection. We found that chronic infection drove MNV-specific tissue-resident memory (Trm) CD8(+) T cells to a differentiation state resembling inflationary effector responses against latent cytomegalovirus with only limited evidence of exhaustion...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29028201/summed-area-technique-for-cube-maps
#9
Yi Xiao, Tze-Yui Ho, Chi-Sing Leung
The original Summed Area Table (SAT) structure is designed for handling 2D rectangular data. Due to the nature of spherical functions, the SAT structure cannot handle cube maps directly. This paper proposes a new SAT structure for cube maps and develops the corresponding lookup algorithm. Our formulation starts by considering a cube map as part of an auxiliary 3D function defined in a 3D rectangular space. We interpret the 2D integration process over the cube map surface as a 3D integration over the auxiliary 3D function...
October 11, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29027368/expression-of-fluorescent-proteins-in-lactobacillus-rhamnosus-to-study-host-microbe-and-microbe-microbe-interactions
#10
Irina Spacova, Elke Lievens, Tine Verhoeven, Hans Steenackers, Jos Vanderleyden, Sarah Lebeer, Mariya I Petrova
Probiotic Lactobacillus strains are widely used to benefit human and animal health, although the exact mechanisms behind their interactions with the host and the microbiota are largely unknown. Fluorescent tagging of live probiotic cells is an important tool to unravel their modes of action. In this study, the implementation of different heterologously expressed fluorescent proteins for the labelling of the model probiotic strains Lactobacillus rhamnosusGG (gastrointestinal) and Lactobacillus rhamnosusGR-1 (vaginal) was explored...
October 13, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29024880/experience-with-and-amount-of-postpartum-maternity-care-comparing-women-who-rated-the-care-they-received-from-the-maternity-care-assistant-as-good-or-less-than-good-care
#11
C I Baas, T A Wiegers, T P de Cock, J J H M Erwich, E R Spelten, E K Hutton
OBJECTIVE: The postpartum period is an important time in the lives of new mothers, their children and their families. The aim of postpartum care is 'to detect health problems of mother and/or baby at an early stage, to encourage breastfeeding and to give families a good start' (Wiegers, 2006). The Netherlands maternity care system aims to enable every new family to receive postpartum care in their home by a maternity care assistant (MCA). In order to better understand this approach, in this study we focus on women who experienced the postpartum care by the MCA as 'less than good' care...
September 19, 2017: Midwifery
https://www.readbyqxmd.com/read/29024869/mapping-midwifery-and-obstetric-units-in-england
#12
Denis Walsh, Helen Spiby, Celia P Grigg, Miranda Dodwell, Christine McCourt, Lorraine Culley, Simon Bishop, Jane Wilkinson, Dawn Coleby, Lynne Pacanowski, Jim Thornton, Sonia Byers
OBJECTIVE: to describe the configuration of midwifery units, both alongside&free-standing, and obstetric units in England. DESIGN: national survey amongst Heads of Midwifery in English Maternity Services SETTING: National Health Service (NHS) in England PARTICIPANTS: English Maternity Services Measurements descriptive statistics of Alongside Midwifery Units and Free-standing Midwifery Units and Obstetric Units and their annual births/year in English Maternity Services FINDINGS: alongside midwifery units have nearly doubled since 2010 (n = 53-97); free-standing midwifery units have increased slightly (n = 58-61)...
September 21, 2017: Midwifery
https://www.readbyqxmd.com/read/29024710/determination-of-complex-subclonal-structures-of-haematological-malignancies-by-multiplexed-genotyping-of-blood-progenitor-colonies
#13
Francesca L Nice, Charlie E Massie, Thorsten Klampfl, Anthony R Green
Current next generation sequencing (NGS) technologies allow unprecedented insights into the mutational profiles of tumours. Recent studies in myeloproliferative neoplasms have further demonstrated that not only the mutational profile, but also the order in which these mutations are acquired is relevant for our understanding of the disease. Our ability to assign mutation order from NGS data alone, is however limited. Here we present a strategy of highly multiplexed genotyping of burst forming unit-erythroid (BFU-E) colonies based on NGS results to assess subclonal tumour structure...
October 9, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/29023584/intravenous-fluid-prescribing-errors-in-children-mixed-methods-analysis-of-critical-incidents
#14
Richard L Conn, Steven McVea, Angela Carrington, Tim Dornan
INTRODUCTION: Recent National Institute for Health and Care Excellence (NICE) guidelines aim to improve intravenous (IV) fluid prescribing for children, but existing evidence about how and why fluid prescribing errors occur is limited. Studying this can lead to more effective implementation, through education and systems design. AIMS: Identify types of IV fluid prescribing errors reported in practiceAnalyse factors that contribute to errorsProvide guidance to educators and those responsible for designing systems...
2017: PloS One
https://www.readbyqxmd.com/read/29020728/diagnosing-testicular-lumps-in-primary-care
#15
Tom Stonier, Nick Simson, Ben Challacombe
Although the incidence of testicular cancer has increased over the past few decades, testicular tumours are still rare and many GPs will only see one or two new diagnoses in their career. In one UK study, out of 845 patients who had been referred with testicular lumps or pain, only 33 (4%) were diagnosed with testicular cancer. Epididymal cysts, or spermatoceles when containing sperm, were the most common finding, and were found in 228 patients (27%). The second most common finding was hydrocele, a fluid collection between the parietal and visceral layers of the tunica vaginalis, which was found in 96 patients (11%)...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29016597/the-clinical-utility-and-cost-impact-of-cystatin-c-measurement-in-the-diagnosis-and-management-of-chronic-kidney-disease-a-primary-care-cohort-study
#16
Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal
BACKGROUND: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-based estimates of GFR be used to confirm or exclude the diagnosis in people with GFR 45-59 ml/min/1.73 m2 and no albuminuria (CKD G3aA1). Whilst there is good evidence for cystatin C being a marker of GFR and risk in people with CKD, its use to define CKD in this manner has not been evaluated in primary care, the setting in which most people with GFR in this range are managed...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28994502/pro-protein-subtilisin-kexin-9-pcsk9-inhibition-in-practice-lipid-clinic-experience-in-2-contrasting-uk-centres
#17
Monika Kohli, Kinjal Patel, Zofia MacMahon, Radha Ramachandran, Martin A Crook, Timothy M Reynolds, Anthony S Wierzbicki
BACKGROUND: Prescribing criteria have been suggested for proprotein convertase subtilisin kexin-9 (PCSK-9) inhibitors but few studies exist of their real-world effectiveness. METHODS: This study audited PCSK-9 inhibitor therapy in 105 consecutive patients from two hospital centres-a university hospital (UH; n = 70) and a district general hospital (DGH; n = 35). Baseline characteristics including cardiovascular disease risk factors, NICE qualification criteria, efficacy and side effects were assessed...
October 10, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28990322/proteogenomics-gets-onto-the-regulation-of-mrna-decoding-and-translation-into-protein
#18
Hubert Hondermarck
Proteogenomics, the integrative analysis of the proteome and the genome, increasingly provides protein-level insights about the regulation of gene expression and protein translation. Armengaud et al. (Proteomics 2017. volume, pages) nicely illustrate this trend with the first in depth proteomic analysis of the eukaryotic and unicellular intestinal parasite Blastocystis sp. Not only this work constitutes an important milestone towards the proteogenomics profile of this human pathogen, but also it demonstrates at the protein level the occurrence of a specific mechanism of mRNA decoding...
October 9, 2017: Proteomics
https://www.readbyqxmd.com/read/28986328/bridging-the-gap-incorporating-a-semantic-similarity-measure-for-effectively-mapping-pubmed-queries-to-documents
#19
Sun Kim, Nicolas Fiorini, W John Wilbur, Zhiyong Lu
The main approach of traditional information retrieval (IR) is to examine how many words from a query appear in a document. A drawback of this approach, however, is that it may fail to detect relevant documents where no or only few words from a query are found. The semantic analysis methods such as LSA (latent semantic analysis) and LDA (latent Dirichlet allocation) have been proposed to address the issue, but their performance is not superior compared to common IR approaches. Here we present a query-document similarity measure motivated by the Word Mover's Distance...
October 3, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28986090/urinary-tract-infection-in-children-diagnosis-treatment-imaging-comparison-of-current-guidelines
#20
REVIEW
M Okarska-Napierała, A Wasilewska, E Kuchar
BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a frequent disorder of childhood, yet the proper approach for a child with UTI is still a matter of controversy. The objective of this study was to critically compare current guidelines for the diagnosis and management of UTI in children, in light of new scientific data. METHODS: An analysis was performed of the guidelines from: American Academy of Pediatrics (AAP), National Institute for Health and Care Excellence (NICE), Italian Society of Pediatric Nephrology, Canadian Paediatric Society (CPS), Polish Society of Pediatric Nephrology, and European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU)...
September 19, 2017: Journal of Pediatric Urology
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