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https://www.readbyqxmd.com/read/27933224/2-diazo-1-phenyl-2-trifluoromethyl-sulfonyl-ethan-1-one-another-utility-for-electrophilic-trifluoromethylthiolation-reactions
#1
Zhongyan Huang, Kenta Okuyama, Chen Wang, Etsuko Tokunaga, Xiaorui Li, Norio Shibata
2-Diazo-1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one (diazo-triflone) (2) is not only a building block but also a reagent. In this study, diazo-triflone, which was originally used for the synthesis of β-lactam triflones as a trifluoromethanesulfonyl (SO2CF3) building block under catalyst-free thermal conditions, is redisclosed as an effective electrophilic trifluoromethylthiolation reagent under copper catalysis. A broad set of enamines, indoles, β-keto esters, pyrroles, and anilines were nicely transformed into corresponding trifluoromethylthio (SCF3) compounds in good to high yields by diazo-triflone under copper catalysis via an electrophilic-type reaction...
June 2016: ChemistryOpen
https://www.readbyqxmd.com/read/27933145/ensuring-timely-thromboprophylaxis-on-a-medical-assessment-unit
#2
Oluwatosin Akinbobuyi, Louise Shalders, Tim Nokes
The Department of Health has defined hospital acquired venous thromboembolism (VTE) as any VTE event occurring within 90 days of hospital admission or surgery. (1) Hospital acquired thrombosis (HAT) is common during and after hospital admission and is considered a major patient safety issue. Current NICE guideline (CG 92) 2010, recommends that medical patients assessed at risk of VTE should have pharmacological prophylaxis commenced as soon as possible after risk assessment has been completed and continued until the patient is no longer at increased risk of VTE...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27932824/nice-guidance-delays-mouth-cancer-diagnosis
#3
(no author information available yet)
No abstract text is available yet for this article.
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932716/could-the-veterinary-profession-learn-from-nice
#4
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27932317/end-of-life-care-for-infants-children-and-young-people-with-life-limiting-conditions-summary-of-nice-guidance
#5
Gemma Villanueva, M Stephen Murphy, David Vickers, Emily Harrop, Katharina Dworzynski
No abstract text is available yet for this article.
December 8, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27930288/experimental-evolution-reveals-hyperparasitic-interactions-among-transposable-elements
#6
Émilie Robillard, Arnaud Le Rouzic, Zheng Zhang, Pierre Capy, Aurélie Hua-Van
Transposable elements (TEs) are repeated DNA sequences that can constitute a substantial part of genomes. Studying TEs' activity, interactions, and accumulation dynamics is thus of major interest to understand genome evolution. Here, we describe the transposition dynamics of cut-and-paste mariner elements during experimental (short- and longer-term) evolution in Drosophila melanogaster Flies with autonomous and nonautonomous mariner copies were introduced in populations containing no active mariner, and TE accumulation was tracked by quantitative PCR for up to 100 generations...
December 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27928660/economic-evaluation-of-community-based-case-management-of-patients-suffering-from-chronic-obstructive-pulmonary-disease
#7
Sabrina Storgaard Sørensen, Kjeld Møller Pedersen, Ulla Møller Weinreich, Lars Ehlers
OBJECTIVES: To analyse the cost effectiveness of community-based case management for patients suffering from chronic obstructive pulmonary disease (COPD). METHODS: The study took place in the third largest municipality in Denmark and was conducted as a randomised controlled trial with 12 months of follow-up. A total of 150 patients with COPD were randomised into two groups receiving usual care and case management in addition to usual care. Case management included among other things self care proficiency, medicine compliance, and care coordination...
December 7, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27927818/interdisciplinary-management-of-hip-fracture
#8
Cameron Swift, Saoussen Ftouh, Patrick Langford, Timothy S Chesser, Antony Johanssen
Hip fracture is a prevalent age-associated occurrence incorporating both medical and surgical need and a major challenge to public health and NHS resources. Effective management requires coordinated collaboration across specialties, professions and services. This concise guideline focuses on interdisciplinary aspects of hip fracture management abstracted from National Institute for Health and Care Excellence (NICE) clinical guideline (CG124), including the concept and implementation of the Hip Fracture Programme, detection and management of comorbidity and delirium, optimal analgesia, timing of surgery, multidisciplinary mobilisation, rehabilitation and hospital discharge...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27927119/recognition-and-management-of-sepsis-in-early-infancy
#9
Joanna Barnden, Vanessa Diamond, Paul Anthony Heaton, Siba Prosad Paul
Serious bacterial and viral infections occurring in early infancy are important factors affecting morbidity and mortality. Recognition of sepsis by healthcare professionals is vital and allows initiation of appropriate early treatment which can be life-saving and improve outcomes for these infants greatly. This article outlines the leading causes of sepsis, for example, group B Streptococcus (GBS), Escherichia coli and herpes simplex virus. We discuss the non-specific ways in which an infant with a serious infection may present to health professionals and highlight crucial features to look for in the history and during examination of an unwell infant, and these include 'red-flag' signs and symptoms that should be carefully elicited...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27927116/the-nurse-s-role-in-childhood-diabetes
#10
Daniel Allen
Essential facts The National Institute for Health and Care Excellence (NICE) has published a quality standard on diabetes in children and young people. NICE quality standards describe high-priority areas for improvement and consist of specific, measurable statements designed to achieve better care. Diabetes is becoming more common in the UK. The latest National Paediatric Diabetes Audit says the number of children and young people cared for in children's diabetes units is rising by 4% per year. In 2014-15, the prevalence in England and Wales of type 1 diabetes in those aged 15 and under was 192 per 100,000 of the general population, with slightly more males affected than females...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27927112/reshaping-policy-to-deliver-holistic-care-for-adolescents-with-crohn-s-disease
#11
Claudia Smith, Sheryl Gettings
The number of adolescents with Crohn's disease (CD) is rising, with one third of cases diagnosed before turning 21 years old. Evidence shows that long-term medical intervention, school absence and the physical toll of CD on the growing adolescent also have a psychological effect on patients. In addition, poorly defined transition pathways are extending these problems into adulthood. The National Institute for Health and Care Excellence (NICE) guidelines are important in shaping service delivery and distribution...
December 8, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27920085/quality-of-prescribing-of-antipsychotic-medication-for-people-with-intellectual-disability-under-the-care-of-uk-mental-health-services-a-cross-sectional-audit-of-clinical-practice
#12
Carol Paton, Sumera Bhatti, Kiran Purandare, Ashok Roy, Tre Barnes
OBJECTIVES: To determine the prevalence and quality of antipsychotic prescribing for people with intellectual disability (ID). DESIGN: A clinical audit of prescribing practice in the context of a quality improvement programme. Practice standards for audit were derived from relevant, evidence-based guidelines, including NICE. Data were mainly collected from the clinical records, but to determine the clinical rationale for using antipsychotic medication in individual cases, prescribers could also be directly questioned...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27919913/when-the-price-is-right-drug-costing-and-nice-approval
#13
Nigel Hawkes
No abstract text is available yet for this article.
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27915384/male-infertility-following-inguinal-hernia-repair-a-systematic-review-and-pooled-analysis
#14
REVIEW
A Kordzadeh, M O Liu, N V Jayanthi
INTRODUCTION: The aim of this systematic review is to establish the clinical impact of open (mesh and/or without mesh) and laparoscopic hernia repair (transabdominal pre-peritoneal (TAP) and/or totally extra-peritoneal (TEP)) on male fertility. The incidence of male infertility following various types of inguinal hernia repair is currently unknown. The lack of high-quality evidence has led to various speculations, suggestions and reliance on anecdotal experience in the clinical practice...
December 3, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27915121/predicting-individual-brain-functional-connectivity-using-a-bayesian-hierarchical-model
#15
Tian Dai, Ying Guo
Network-oriented analysis of functional magnetic resonance imaging (fMRI), especially resting-state fMRI, has revealed important association between abnormal connectivity and brain disorders such as schizophrenia, major depression and Alzheimer's disease. Imaging-based brain connectivity measures have become a useful tool for investigating the pathophysiology, progression and treatment response of psychiatric disorders and neurodegenerative diseases. Recent studies have started to explore the possibility of using functional neuroimaging to help predict disease progression and guide treatment selection for individual patients...
November 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/27915045/in-vivo-selection-of-heterotypically-interacting-transmembrane-helices-complementary-helix-surfaces-rather-than-conserved-interaction-motifs-drive-formation-of-transmembrane-hetero-dimers
#16
Dominik Steindorf, Dirk Schneider
Single pass transmembrane proteins make up almost half of the whole transmembrane proteome. Contacts between such bitopic transmembrane proteins are common, and oligomerization of their single transmembrane helix is involved in triggering and regulation of signal transduction across cell membranes. In several recent analyses the distribution of amino acids at helix-helix contact sides has been analyzed, and e.g. a preference of amino acids with small side chains has been identified. Here we select amino acids, amino acid pairings and amino acid motifs, which mediate strong interactions of single-span transmembrane α-helices...
November 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27913449/nice-advises-routine-high-sensitivity-troponin-tests-to-rule-out-mi
#17
Jacqui Wise
No abstract text is available yet for this article.
December 1, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27908906/nice-issues-guidance-on-policies-to-reduce-vehicle-emissions
#18
Ingrid Torjesen
No abstract text is available yet for this article.
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27908312/calcinosis-in-poly-dermatomyositis-clinical-and-laboratory-predictors-and-treatment-options
#19
Micaela Fredi, Francesca Bartoli, Ilaria Cavazzana, Angela Cerebelli, Nice Carabellese, Angela Tincani, Minoru Satoh, Franco Franceschini
OBJECTIVES: We aimed to identify the possible clinical and laboratory predictors of calcinosis in a cohort of patients with a diagnosis of polymyositis (PM) and dermatomyositis (DM). METHODS: We carried out a retrospective analysis of a cohort of myositis patients attending our clinic between January 2013 and May 2014. RESULTS: 74 patients (58 females, 16 males) with PM (30 cases), DM (30 cases), overlap syndrome (13 cases) and inclusion body myositis (1 case) were enrolled...
November 14, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27905265/learning-together-part-2-training-costs-and-health-gain-a-cost-analysis
#20
Katherine Cullen, Wendy Riches, Chloe Macaulay, John Spicer
: Learning Together is a complex educational intervention aimed at improving health outcomes for children and young people. There is an additional cost as two doctors are seeing patients together for a longer appointment than a standard general practice (GP) appointment. Our approach combines the impact of the training clinics on activity in South London in 2014-15 with health gain, using NICE guidance and standards to allow comparison of training options. METHODS: Activity data was collected from Training Practices hosting Learning Together...
December 1, 2016: Education for Primary Care
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