NICE

No abstract text is available yet for this article.

No abstract text is available yet for this article.

BACKGROUND: Several cadaveric studies demonstrate reliable localization of the transverse sinus and the transverse sigmoid junction (TSJ). These studies use the line drawn from the inion to the posterior root of the zygoma (IZ) and the asterion, respectively. We investigated how the size difference between the right and left transverse sinuses (TS) and sigmoid sinuses (SS) affected the accuracy of their respective superficial landmarks, particularly with regards to where this relationship may result in unsafe and/or complicated surgical access...

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Introduction The National Institute for Health and Care Excellence (NICE) guideline on the diagnosis and management of the menopause states that women who are likely to go through the menopause as a result of surgical treatment should be offered information about the menopause and the importance of starting hormonal replacement therapy before they have their treatment. Objectives To determine compliance with NICE guidelines at the Royal Derby Hospital. Study design We undertook a retrospective review of all pre-menopausal women undergoing bilateral salpingo-oophorectomy for benign pathology between 1 January 2016 and 30 June 2016...

The flocculant made from natural polymers gained prominence in recent years due to its eco-friendliness and low cost. In this study, two natural polymers of chitosan and fulvic acid were successfully grafted with a synthetic monomer of acrylamide as a new type of flocculant. The prepared chitosan-acrylamide-fulvic acid (CAMFA) exhibited an excellent capacity to remove three typical dyes, the color removal ratios were 97.0%, 91.6%, and 38.2%, respectively, at the dosage of 283mg/L for 100mg/L of acid blue 113, reactive black 5 and methyl orange...

Type III interferon (IFNλ) and type I IFN (IFNα/β) have overlapping antiviral activities in the lung. In this issue of Immunity, Galani et al. (2017) identify a critical early role for IFNλ, not shared by IFNα/β, in protection of the lung following influenza virus infection.

New guidelines from the National Institute for Health and Care Excellence (NICE) focus on children with cerebral palsy.

The care of people with motor neuron disease/amyotrophic lateral sclerosis is often complex and involves a wide multidisciplinary team approach. The National Institute for Health and Care Excellence (NICE) in the UK has produced an evidence based guideline for the management of patients. This has made recommendations, based on clear evidence or consensus discussion. The evidence is often limited and areas for further research are suggested.

BACKGROUND: The release of damage-associated molecular pattern molecules (DAMPs) in the extracellular space secondary to injury has been shown to cause systemic activation of the coagulation system and endothelial cell damage. We hypothesized that pediatric trauma patients with increased levels of histone-complexed DNA fragments (hcDNA) would have evidence of coagulopathy and endothelial damage that would be associated with poor outcomes. METHODS: We conducted a prospective observational study of 149 pediatric trauma patients and 62 control patients at two level 1 pediatric trauma centers from 2013-2016...

BACKGROUND: People with learning disabilities (LD) are particularly vulnerable to mental health and behavioural difficulties, and it has been shown that regular exercise can improve psychosocial well-being as well as physical fitness. This research aims to explore the experiences of men with LD detained in secure settings who have engaged in community football training programmes and identify the benefits of such provision. METHOD: Interviews were conducted with eight patients in a forensic LD service, discussing their experiences of participating in community football...

OBJECTIVES: The aim of this study was to review 5 years of activity from a new system devised by the National Institute for Health and Care Excellence (NICE), for assessing medical devices and diagnostics aimed at identifying and speeding adoption of technologies with clinical and cost advantages, compared with current practice in the United Kingdom healthcare system. METHODS: All eligible notified technologies were classified using the Food and Drug Administration and Global Medical Device Nomenclature nomenclatures...

The objective of this paper is to introduce a novel fast modeling tool called peri-ultrasound for linear/nonlinear ultrasonic wave propagation modeling. This modeling approach is based on peridynamic theory. It does not require monitoring of the crack clapping phenomenon or artificially changing the stiffness of the element when two surfaces of the crack come in contact. Peri-ultrasound tool enables us to detect the material nonlinearity in very early stages of crack growth. Nonlinear ultrasonic behavior could be nicely modeled by the proposed peri-ultrasound tool...

We report complex phenomena arising among financial analysts, who gather information and generate investment advice, and elucidate them with the help of a theoretical model. Understanding how analysts form their forecasts is important in better understanding the financial market. Carrying out big-data analysis of the analyst forecast data from I/B/E/S for nearly thirty years, we find skew distributions as evidence for emergence of complexity, and show how information asymmetry or disparity affects financial analysts' forming their forecasts...

BACKGROUND: Over 20 distressing gastrointestinal symptoms affect many patients after pelvic radiotherapy, but in the United Kingdom few are referred for assessment. Algorithmic-based treatment delivered by either a consultant gastroenterologist or a clinical nurse specialist has been shown in a randomized trial to be statistically and clinically more effective than provision of a self-help booklet. In this study, we assessed cost-effectiveness. METHODS: Outcomes were measured at baseline (pre-randomization) and 6 months...

Our clinical update on new National Institute for Health and Care Excellence (NICE) guidance on tackling antimicrobial resistance.

BACKGROUND: Most cycling studies involve professional cyclists. Because training may affect riding style, it is of interest to determine the physiological basis for the personal choice of cycling cadence in nonprofessional cyclists. METHODS: Eleven nonprofessional (5.2±1.7-year-riding experience) male road cyclists, aged 35.0±11.0 years, underwent four separate laboratory test sessions. The first two sessions included habituation, anthropometry, V˙O2max,$\dot V{{\text{O}}_{\text{2}}}{\text{max}},$ and lactate threshold (LaTH) measurements...

Over recent years, the UK's National Institute for Health and Care Excellence (NICE) has implemented or proposed several amendments to its methods and processes for the economic evaluation of health technologies within the National Health Service (NHS) [1-5]. These amendments have modified the 'value' that NICE assigns to health gains attributable to specific technologies when provided to patients with distinct characteristics. This raises fundamental equity issues that should be of concern to all NHS patients and other stakeholders...

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When children's self-interests are at odds with their moral considerations, what do they do? In the current study of 5- and 6-year-olds (N=160), we asked (a) whether children would select the offering of a do-gooder over a neutral individual at a personal cost, (b) whether they would reject the offering of a wrongdoer over a neutral individual at a personal cost, and (c) whether these two types of decisions involve comparable levels of conflict. In the absence of material considerations, children preferred a nice character to a neutral one, but this preference was easily overcome for material gain; children accepted a larger offering from a neutral source over a smaller offering from a nice source...