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https://www.readbyqxmd.com/read/29228454/new-semiparametric-method-for-predicting-high-cost-patients
#1
Adam Maidman, Lan Wang
Motivated by the Medical Expenditure Panel Survey containing data from individuals' medical providers and employers across the United States, we propose a new semiparametric procedure for predicting whether a patient will incur high medical expenditure. Problems of the same nature arise in many other important applications where one would like to predict if a future response occurs at the upper (or lower) tail of the response distribution. The common practice is to artificially dichotomize the response variable and then apply an existing classification method such as binomial regression or a classification tree...
December 11, 2017: Biometrics
https://www.readbyqxmd.com/read/29227776/the-specialty-and-naughty-nice-tendency-audit-santa-which-medical-specialists-can-be-trusted-to-follow-recipes
#2
Shian Miller, Tamara C Johnson
OBJECTIVE: To evaluate the influence of medical specialty on the likelihood of doctors making the Naughty or Nice lists this Christmas. DESIGN, SETTING, AND PARTICIPANTS: A quantitative observational study. Doctors in a medical parent Facebook group were asked about their specialty and their tendency to follow recipes. MAIN OUTCOME MEASURES: Self-reported tendency to follow the recipe (always, sometimes, never) as an indicator of rule-breaking behaviour, extrapolated as indicating Naughty (unlikely to follow a recipe) or Nice (always follow recipes) tendencies, and consequently the likelihood of being included in the Nice list this Christmas...
December 11, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29226430/3dtee-imaging-of-a-descending-aorta-floating-thrombus-in-a-patient-with-calciphylaxis
#3
Konstantinos C Theodoropoulos, Alexandros Papachristidis, Michael Papitsas, Jonathan Byrne, Mark J Monaghan
We present a case of a 68-year-old man with calciphylaxis, who was found to have a floating thrombus in the descending aorta on a transesophageal echocardiogram. The use of 3D echocardiography demonstrated nicely the free motion of the thrombus, emerging from an atherosclerotic plaque in the descending aorta. Anticoagulation was started for thromboembolism prevention.
December 11, 2017: Echocardiography
https://www.readbyqxmd.com/read/29222670/venetoclax-for-treating-chronic-lymphocytic-leukaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#4
REVIEW
Hema Mistry, Chidozie Nduka, Martin Connock, Jill Colquitt, Theodoros Mantopoulos, Emma Loveman, Renata Walewska, James Mason
Venetoclax is licensed to treat relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL). As part of the Single Technology Appraisal (STA) ID944, the National Institute for Health and Care Excellence (NICE) invited AbbVie, the manufacturer, to submit evidence on the use of venetoclax, within its licensed indication. The Evidence Review Group (ERG), Warwick Evidence, was asked to provide an independent and critical review of the submitted evidence. Evidence came from three single-arm trials in CLL patients with or without 17p deletion [del(17p])/TP53 chromosomal abnormalities...
December 8, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#5
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29214389/using-real-world-data-in-health-technology-assessment-hta-practice-a-comparative-study-of-five-hta-agencies
#6
Amr Makady, Ard van Veelen, Páll Jonsson, Owen Moseley, Anne D'Andon, Anthonius de Boer, Hans Hillege, Olaf Klungel, Wim Goettsch
BACKGROUND: Reimbursement decisions are conventionally based on evidence from randomised controlled trials (RCTs), which often have high internal validity but low external validity. Real-world data (RWD) may provide complimentary evidence for relative effectiveness assessments (REAs) and cost-effectiveness assessments (CEAs). This study examines whether RWD is incorporated in health technology assessment (HTA) of melanoma drugs by European HTA agencies, as well as differences in RWD use between agencies and across time...
December 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29211741/an-economic-evaluation-of-alexander-technique-lessons-or-acupuncture-sessions-for-patients-with-chronic-neck-pain-a-randomized-trial-atlas
#7
Holly Essex, Steve Parrott, Karl Atkin, Kathleen Ballard, Martin Bland, Janet Eldred, Catherine Hewitt, Ann Hopton, Ada Keding, Harriet Lansdown, Stewart Richmond, Helen Tilbrook, David Torgerson, Ian Watt, Aniela Wenham, Julia Woodman, Hugh MacPherson
OBJECTIVES: To assess the cost-effectiveness of acupuncture and usual care, and Alexander Technique lessons and usual care, compared with usual GP care alone for chronic neck pain patients. METHODS: An economic evaluation was undertaken alongside the ATLAS trial, taking both NHS and wider societal viewpoints. Participants were offered up to twelve acupuncture sessions or twenty Alexander lessons (equivalent overall contact time). Costs were in pounds sterling. Effectiveness was measured using the generic EQ-5D to calculate quality adjusted life years (QALYs), as well as using a specific neck pain measure-the Northwick Park Neck Pain Questionnaire (NPQ)...
2017: PloS One
https://www.readbyqxmd.com/read/29210621/pathways-to-pleasure-older-adult-women-s-reflections-on-being-sexual-beings
#8
Kate A Morrissey Stahl, Jerry Gale, Denise C Lewis, Doug Kleiber
Older adult women make up a growing part of the population, and yet literature on the sexual activity over their life spans is lacking. This qualitative interview study explored the experience of 16 women aged 57-91 to better understand sexual pleasure over a lifetime. The participants described having to challenge cultural rules to create a supportive environment for sexual expression. Having access to Novel contexts in which to learn, cultivating Intimacy with partners and with oneself, being Creative with sexual activities, and Extending one's sense of sexual possibility into advanced age (NICE) supported sexual pleasure as women aged...
December 6, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/29210453/a-combined-approach-of-infrared-spectroscopy-and-multivariate-analysis-for-the-simultaneous-determination-of-sugars-and-fructans-in-strawberry-juices-during-storage
#9
Lucía Cassani, Mauricio Santos, Esteban Gerbino, María Del Rosario Moreira, Andrea Gómez-Zavaglia
In this work, a Fourier transform mid-infrared spectroscopy (FTIR)-based method was developed for simultaneously quantifying simple sugars and exogenously added fructooligosaccharides (FOS) in strawberry juices preserved for up to 14 d using nonthermal techniques (geraniol and vanillin+ultrasound). The main spectral differences were observed in the 1200 to 900 cm-1 region. The presence of FOS was identified by the typical bands at 1134, 1034, and 935 cm-1 . During storage, a significant decrease of sucrose was concomitant to an increase of glucose and fructose in juices stored without any previous preservation treatment, as determined by high-performance liquid chromatography (HPLC)...
December 6, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29207279/biofabrication-of-morphology-improved-cadmium-sulfide-nanoparticles-using-shewanella-oneidensis-bacterial-cells-and-ionic-liquid-for-toxicity-against-brain-cancer-cell-lines
#10
Li Wang, Siyuan Chen, Yiming Ding, Qiang Zhu, Nijia Zhang, Shuqing Yu
The present work determines the anticancer activity of bio-mediated synthesized cadmium sulfide nanoparticles using the ionic liquid and bacterial cells (Shewanella oneidensis). Bacterial cells have been exposed to be important resources that hold huge potential as ecofriendly, cost-effective, evading toxic of dangerous chemicals and the alternative of conventional physiochemical synthesis. The Shewanella oneidensis is an important kind of metal reducing bacterium, known as its special anaerobic respiratory and sulfate reducing capacity...
November 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29206359/parent-infant-co-sleeping-and-the-implications-for-sudden-infant-death-syndrome
#11
Joanne Straw, Pat Jones
In 2015 the National Institute for Health and Care Excellence (NICE) updated its 2006 guideline to clarify the association between parent infant co-sleeping and sudden infant death syndrome (SIDS). The practice of co-sleeping is a topic of continuing controversy and debate. Rather than highlighting the risks, the emphasis of the NICE guideline is to provide parents with balanced information so that they can make informed decisions about where their babies sleep. This contradicts previous public health messages on co-sleeping that discourages parents from the practice...
December 5, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29206152/connecting-the-mind-body-split-understanding-the-relationship-between-symptoms-and-emotional-well-being-in-chronic-pain-and-functional-gastrointestinal-disorders
#12
REVIEW
Line Caes, Alex Orchard, Deborah Christie
Paediatric chronic conditions, e.g., chronic pain and functional gastrointestinal disorders, are commonly diagnosed, with fatigue, pain and abdominal discomfort the most frequently reported symptoms across conditions. Regardless of whether symptoms are connected to an underlying medical diagnosis or not, they are often associated with an increased experience of psychological distress by both the ill child and their parents. While pain and embarrassing symptoms can induce increased distress, evidence is also accumulating in support of a reciprocal relationship between pain and distress...
December 5, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29192397/ustekinumab-for-treating-moderately-to-severely-active-crohn-s-disease-after-prior-therapy-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#13
Robert Hodgson, Matthew Walton, Mousumi Biswas, Teumzghi Mebrahtu, Nerys Woolacott
As part of the single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited Janssen to submit evidence on the clinical and cost effectiveness of their drug ustekinumab, an interleukin-12/23 inhibitor, for treating moderate-to-severe active Crohn's disease (CD). The Centre for Reviews and Dissemination (CRD) and Centre for Health Economics (CHE) Technology Appraisal Group at the University of York was commissioned to act as the independent Evidence Review Group (ERG)...
November 30, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29190430/evaluating-uk-national-guidance-for-screening-of-children-for-tb-a-prospective-multi-centre-study
#14
Beate Kampmann, James A Seddon, James Paton, Zohreh Nademi, Denis Keane, Bhanu Williams, Amanda Williams, Sue Liebeschutz, Anna Riddell, Jolanta Bernatoniene, Sanjay Patel, Nuria Martinez, Paddy McMaster, Robindra Basu-Roy, Steven B Welch
Rationale and Objective In order to identify infected contacts of tuberculosis (TB) cases, the UK National Institute for Health and Care Excellence (NICE) recommended the addition of interferon-gamma release assays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children screened TST-positive but IGRA-negative. We carried out a cohort study to evaluate the risk of TB disease in this group. Methods Children exposed to an infectious case of TB in their household were recruited from 11 paediatric TB clinics...
November 30, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29190328/the-computational-anatomy-of-visual-neglect
#15
Thomas Parr, Karl J Friston
Visual neglect is a debilitating neuropsychological phenomenon that has many clinical implications and-in cognitive neuroscience-offers an important lesion deficit model. In this article, we describe a computational model of visual neglect based upon active inference. Our objective is to establish a computational and neurophysiological process theory that can be used to disambiguate among the various causes of this important syndrome; namely, a computational neuropsychology of visual neglect. We introduce a Bayes optimal model based upon Markov decision processes that reproduces the visual searches induced by the line cancellation task (used to characterize visual neglect at the bedside)...
November 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29183986/new-test-for-asthma-will-save-nhs-millions-says-nice
#16
Jacqui Wise
No abstract text is available yet for this article.
November 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29183884/nice-to-ban-mesh-for-vaginal-wall-prolapse
#17
Jacqui Wise
No abstract text is available yet for this article.
November 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29181091/parenting-and-child-mental-health
#18
Rachael Ryan, Christine O'Farrelly, Paul Ramchandani
This paper reviews parenting programmes and their effectiveness with families of young children and highlights additional resources for primary care practitioners. Typically, 30% of GP consultations concern child behaviour problems and established behaviour problems can have lasting effects on children's life chances. These problems can be identified in infancy and toddlerhood.Parenting is a key risk factor in their development and maintenance, yet is also amenable to change. In this paper we consider six parenting programmes that are widely evaluated and/or available in the U...
November 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/29179134/a-randomised-phase-ii-study-of-chemoradiotherapy-with-or-without-nimotuzumab-in-locally-advanced-oesophageal-cancer-nice-trial
#19
Gilberto de Castro Junior, José Getúlio Segalla, Sérgio Jobim de Azevedo, Carlos José Andrade, Daniel Grabarz, Bruno de Araújo Lima França, Auro Del Giglio, Nicolas Silva Lazaretti, Maria Nunes Álvares, José Luiz Pedrini, Celio Kussumoto, João Nunes de Matos Neto, Nora Manoukian Forones, Hezio Jadir Fernandes Júnior, Giuliano Borges, Gustavo Girotto, Ismael Dale Cotrim Guerreiro da Silva, Fauze Maluf-Filho, Nils Gunnar Skare
PURPOSE: Chemoradiotherapy is the standard treatment for patients with inoperable locally advanced oesophageal cancer. We sought to assess the safety and efficacy of chemoradiation combined with nimotuzumab, a humanised antibody directed against epidermal growth factor receptor (EGFR). PATIENTS AND METHODS: Untreated patients with inoperable locally advanced oesophageal cancer and no distant metastases were randomised to chemoradiotherapy (cisplatin and fluorouracil combined with external beam radiation) alone or in combination with nimotuzumab...
November 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29178547/-safe-by-design-ligand-coated-zno-nanocrystals-engineered-by-an-organometallic-approach-unique-physicochemical-properties-and-low-negative-toxicological-effect-toward-lung-cells
#20
Janusz Lewinski, Małgorzata Wolska-Pietkiewicz, Katarzyna Tokarska, Agnieszka Grala, Anna Wojewódzka, Elżbieta Chwojnowska, Justyna Grzonka, Piotr Cywiński, Krzysztof Kruczała, Zbigniew Sojka, Michał Chudy
The unique physicochemical properties and biocompatibility of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on the nanocrystal-ligand interface which is largely determined by synthetic procedures. Advancing a novel organometallic self-supporting approach we prepared and fully characterized stable ZnO NCs coated with densely packed 2-(2-methoxyethoxy)acetate ligand shell (i.e. ligand acting as a miniPEG prototype) with the average core size and hydrodynamic diameter of 4-5 nm and ca. 12 nm, respectively, as a model system for biological studies...
November 27, 2017: Chemistry: a European Journal
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