Read by QxMD icon Read


Lucie Chauvelin, Morgane Gindt, Bertrand Olliac, Philippe Robert, Susanne Thümmler, Florence Askenazy
In the actual context of terrorism targeting children and families, it seems essential to describe different experiences of pediatric psychological emergency devices after such unexpected mass trauma. Here we testify our experience of the psychological emergency care setup dedicated to children and families during the first 48 hours after the terrorist attack of Nice, France, on July 14, 2016. Activated within the hour following the attack, the device included two child psychiatry teams turning over each day, receiving at least 163 individuals (99 children and 64 adults) within the first 2 days...
June 19, 2018: Disaster Medicine and Public Health Preparedness
Giuseppe La Rosa, Isabelle Vallée, Gianluca Marucci, François Casabianca, Ennio Bandino, Fabio Galati, Pascal Boireau, Edoardo Pozio
BACKGROUND: The zoonotic nematode Trichinella britovi was discovered in two neighboring Mediterranean islands of Corsica and Sardinia, almost simultaneously at the beginning of the 21st century. An epidemiological link between the two parasite populations was generally assumed. In 2015, an outbreak of trichinellosis in Nice, the South of France, was reportedly caused by the consumption of raw pork delicatessen imported from Corsica. The aims of the present study were to investigate, by multilocus genotype (MLG) analyses, the hypothesis of the common origin of the Corsican and Sardinian T...
June 19, 2018: Parasites & Vectors
Helge Kasch, Troels S Jensen
Background/aims The presence and severity of concussion related symptoms after acute whiplash injury are debatable. In this study we examine the distribution and development of the burden of concussion related symptoms in whiplash patients. Methods Consecutively 141 acute whiplash patients and 40 ankle injured controls were recruited from emergency units and were examined after 1 week, 1, 3, 6, 12 months obtaining neck/head VAS score, number-of-non-painful complaints, epidemiological, social, psychological data and neurological examination, active neck mobility, and furthermore muscle tenderness and pain response, strength and duration of neck muscles...
December 29, 2017: Scandinavian Journal of Pain
Jingchuan Sun, Qingjie Kong, Yong Yang, Jiangang Shi, Yang Hou, Ximing Xu, Yuan Wang, Haisong Yang, Yongfei Guo, Guodong Shi, Yingjie Wang, Peng Zhang
PURPOSE: This study is to determine whether implantation of a newly designed non-fusion intracorporeal enhancement (NICE) system is an effective and a safe way for the treatment of osteoporotic vertebral compression fracture (OVCF). METHODS: 13 OVCF patients (10 women, 3 men, mean age 69, T11 to L4) were included. From June 2014 to June 2016 all of them were treated with the NICE system. The clinical and radiological results were both evaluated preoperatively, postoperatively, 24 months follow-up based on the visual analog scale (VAS) and the Oswestry Disability Index (ODI), X-ray, MRI and CT (Height of fractured body and kyphosis Cobb angle)...
June 15, 2018: World Neurosurgery
Speranza Sannino, Sebastiano Stramaglia, Lucas Lacasa, Daniele Marinazzo
Visibility algorithms are a family of methods that map time series into graphs, such that the tools of graph theory and network science can be used for the characterization of time series. This approach has proved a convenient tool, and visibility graphs have found applications across several disciplines. Recently, an approach has been proposed to extend this framework to multivariate time series, allowing a novel way to describe collective dynamics. Here we test their application to fMRI time series, following two main motivations, namely that (a) this approach allows vs to simultaneously capture and process relevant aspects of both local and global dynamics in an easy and intuitive way, and (b) this provides a suggestive bridge between time series and network theory that nicely fits the consolidating field of network neuroscience...
October 1, 2017: Network neuroscience
Rachael Barr, Elliott J Carande, Andrew J Pollard, Simon B Drysdale
BACKGROUND: Viral bronchiolitis is one of the most common causes of hospitalisation in young infants. It has previously been shown that many United Kingdom (UK) hospital Trusts were not compliant with many aspects of the National Institute for Health and Care Excellence (NICE) bronchiolitis guideline prior to its publication. OBJECTIVES: This study aimed to investigate changes in the management of bronchiolitis by hospital Trusts between 2015 (before NICE guideline publication) and 2017, after publication...
June 12, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Sung-Eun Lee, Soo-Young Choi, Soo-Hyun Kim, Saengsuree Jootar, Hyeoung-Joon Kim, Sang-Kyun Sohn, Joon Seong Park, Sung-Hyun Kim, Dae-Young Zang, Suk-Joong Oh, Dong-Wook Kim
The aim of this study was to investigate the efficacy of nilotinib (NIL) versus high-dose imatinib (IM) versus sustained standard-dose IM for patients with chronic myeloid leukemia (CML) with suboptimal molecular response to first-line IM therapy. Patients with CML who achieved complete cytogenetic response (CCyR) but not major molecular response (MMR) after 18-24 months on first-line IM therapy were enrolled and divided into three treatment cohorts: NIL 800 mg/day (Cohort 1, n = 28) and IM 800 mg/day (Cohort 2, n = 28) in the RE-NICE study, and sustained IM 400 mg/day (Cohort 3, n = 52) in clinical practice...
June 7, 2018: Leukemia Research
N Metrebian, T Weaver, S Pilling, J Hellier, S Byford, J Shearer, L Mitcheson, M Astbury, P Bijral, N Bogdan, O Bowden-Jones, E Day, J Dunn, E Finch, S Forshall, A Glasper, G Morse, S Akhtar, J Bajaria, C Bennett, E Bishop, V Charles, C Davey, R Desai, C Goodfellow, F Haque, N Little, H McKechnie, J Morris, F Mosler, J Mutz, R Pauli, D Poovendran, E Slater, J Strang
There are approximately 256,000 heroin and other opiate users in England of whom 155,000 are in treatment for heroin (or opiate) addiction. The majority of people in treatment receive opiate substitution treatment (OST) (methadone and buprenorphine). However, OST suffers from high attrition and persistent heroin use even whilst in treatment. Contingency management (CM) is a psychological intervention based on the principles of operant conditioning. It is delivered as an adjunct to existing evidence based treatments to amplify patient benefit and involves the systematic application of positive reinforcement (financial or material incentives) to promote behaviours consistent with treatment goals...
June 13, 2018: Contemporary Clinical Trials
Jill Cadwgan, Jane Goodwin, Charlie Fairhurst
While there remains limited intervention to address the damage to the developing brain, current multidisciplinary management of cerebral palsy (CP) needs to minimise the impact of secondary musculoskeletal complications. A focus on comorbidities to maximise function for activity and participation by supporting the child and family in their environment is required. Comprehensive clinical guidance was published by National Institute for Health and Care Excellence (NICE) earlier this year. This article aims to provide a practical clinical approach to the child and family based on:(1) art: empathy, listening and weighing up the clinical picture of the child and family in context; diagnosis, the need for support and space; and care coordination at the right time; and (2) science: the current science in CP care is rapidly expanding in terms of plasticity, pathophysiology, functional assessments and treatments...
June 15, 2018: Archives of Disease in Childhood. Education and Practice Edition
Megan Majocha, Zachary Davenport, Derek C Braun, Cara Gormally
Science, technology, engineering, and mathematics (STEM) undergraduate research experiences improve success, persistence, and promote a feeling of belonging to a community. Like their hearing peers, deaf STEM majors often participate in undergraduate research experiences. However, deaf students typically interact with hearing faculty lacking experience with deaf students and awareness of Deaf culture, which unintentionally impacts their research experiences. This interview study sought to understand deaf students' research experiences and their relationships with hearing mentors...
2018: Journal of Microbiology & Biology Education: JMBE
Klaus Krüger, Gerd R Burmester, Siegfried Wassenberg, Martin Bohl-Bühler, Matthias H Thomas
OBJECTIVE: The Non Interventional Evaluation with Golumimab (GO-NICE) study aimed to document patient and treatment characteristics as well as clinical effectiveness and safety in adult patients newly treated with the tumour necrosis factor inhibitor golimumab (GLM). DESIGN: Prospective non-interventional study with 24-month observation per patient. SETTING: 158 office-based and clinical-based physicians in Germany. INTERVENTION: GLM administered in the 50 mg dose subcutaneously in monthly intervals under real-life conditions...
June 14, 2018: BMJ Open
K Boswell, H Cameron, J West, C Fleming, S Ibbotson, R Dawe, J Foerster
BACKGROUND: Narrowband - UVB (NB-UVB) treatment for psoriasis is considered expensive. However, existing data are based on estimates and do not consider indirect cost savings. OBJECTIVES: To define actual costs of NB-UVB incurred by the service provider, as well as treatment-associated cost savings. METHODS: Data linkage of (i) comprehensive treatment records, (ii) prescribing data for all NB-UVB treatment episodes spanning six years in a population of 420,000...
June 14, 2018: British Journal of Dermatology
Justin Rueckert, Katherine Devitt, Alexandra Kalof, Juli-Anne Gardner
Lipoblastomas are benign tumors composed of fat cells of varying degrees of maturation, from lipoblasts to mature adipocytes. These tumors typically affect young children under the age of three. Upregulation of the pleomorphic adenoma gene 1 (PLAG1), located on 8q12.1, is the primary driving force for lipoblastoma development. The most common mechanisms for PLAG1 upregulation are rearrangements of 8q11-13 and polysomy 8. We present a unique case of lipoblastoma in a three-year-old boy with a ring chromosome 8...
2018: Journal of the Association of Genetic Technologists
Raffaele Nuzzi, Laura Dallorto, Teresa Rolle
Background: Glaucoma is a leading cause of irreversible blindness worldwide. The increasing interest in the involvement of the cortical visual pathway in glaucomatous patients is due to the implications in recent therapies, such as neuroprotection and neuroregeneration. Objective: In this review, we outline the current understanding of brain structural, functional, and metabolic changes detected with the modern techniques of neuroimaging in glaucomatous subjects. Methods: We screened MEDLINE, EMBASE, CINAHL, CENTRAL, LILACS, Trip Database, and NICE for original contributions published until 31 October 2017...
2018: Frontiers in Neuroscience
Attila Bajtai, Gyula Lajkó, István Szatmári, Ferenc Fülöp, Wolfgang Lindner, István Ilisz, Antal Péter
Normal phase (NP) high-performance liquid and sub- and supercritical fluid chromatographic (both acronymed as SFC) methods have been developed for the enantiomer separation of three basic and three ampholytic structurally related C-3-substituted indole analogs on seven non-ionic (neutral) polysaccharide-based and two chemically entirely different zwitterionic Cinchona alkaloid- and sulfonic acid-based chiral stationary phases (CSPs). In a systematic fashion the effect of the composition of the mobile phase, the nature of the alcohol and amine additives on the retention characteristics and enantioselectivity of the ionizable analytes were investigated...
June 7, 2018: Journal of Chromatography. A
Anton A Ivanov, Clément Falaise, Pavel A Abramov, Michael A Shestopalov, Kaplan Kirakci, Kamil Lang, Mhamad A Moussawi, Maxim N Sokolov, Nikolay G Naumov, Sébastien Floquet, David Landy, Mohamed Haouas, Konstantin A Brylev, Yuri V Mironov, Yann Molard, Stéphane Cordier, Emmanuel Cadot
Water-soluble salts of anionic [Re6Q8(CN)6]4- (Q = S, Se, Te) chalcogenide octahedral rhenium clusters react with γ-cyclodextrin (γ-CD) producing a new type of inclusion compounds. Crystal structures determined through single-crystal X-ray diffraction analysis revealed supramolecular host-guest assemblies resulting from close encapsulations of the octahedral cluster within two γ-CDs. Interestingly, nature of the inner Q ligands influences strongly the host-guest conformation. The cluster [Re₆S₈(CN)6]4- interacts preferentially with the primary faces of the γ-CD while the bulkier clusters [Re6Se8(CN)6]4- and [Re6Te8(CN)6]4- exhibit specific interactions with the secondary faces of the cyclic host...
June 12, 2018: Chemistry: a European Journal
Kevin Washetine, Mehdi Kara-Borni, Simon Heeke, Christelle Bonnetaud, Jean-Marc Félix, Lydia Ribeyre, Coraline Bence, Marius Ilié, Olivier Bordone, Marine Pedro, Priscilla Maitre, Virginie Tanga, Emmanuelle Gormally, Pascal Mossuz, Philippe Lorimier, Charles Hugo Marquette, Jérôme Mouroux, Charlotte Cohen, Sandra Lassalle, Elodie Long-Mira, Bruno Clément, Georges Dagher, Véronique Hofman, Paul Hofman
Collected specimens for research purposes may or may not be made available depending on their scarcity and/or on the project needs. Their protection against degradation or in the event of an incident is pivotal. Duplication and storage on a different site is the best way to assure their sustainability. The conservation of samples at room temperature (RT) by duplication can facilitate their protection. We describe a security system for the collection of non-small cell lung cancers (NSCLC) stored in the biobank of the Nice Hospital Center, France, by duplication and conservation of lyophilized (dried), encapsulated DNA kept at RT...
June 11, 2018: Cancers
Andy Ingram, Mark Harper
Active warming of patients is recommended by The National Institute for Health and Care Excellence (NICE) to prevent inadvertent perioperative hypothermia (IPH). This paper examines the cost effectiveness of one consequence of IPH, an increase in blood loss and the resulting transfusion risk. We quantified the risk and modelled two patient pathways, one with and one without warming, across two different surgery types. We were able to demonstrate the cost effectiveness of active warming based on one consequence even allowing for uncertainties in the model...
January 1, 2018: Journal of Perioperative Practice
Pavel Ryabchuk, Giovanni Agostini, Marga-Martina Pohl, Henrik Lund, Anastasiya Agapova, Henrik Junge, Kathrin Junge, Matthias Beller
Hydrogenation reactions are essential processes in the chemical industry, giving access to a variety of valuable compounds including fine chemicals, agrochemicals, and pharmachemicals. On an industrial scale, hydrogenations are typically performed with precious metal catalysts or with base metal catalysts, such as Raney nickel, which requires special handling due to its pyrophoric nature. We report a stable and highly active intermetallic nickel silicide catalyst that can be used for hydrogenations of a wide range of unsaturated compounds...
June 2018: Science Advances
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"