Thiago Tafarel Galli, Elaine Cristina de Campos, Leandro do Nascimento Camargo, Silvia Fukuzaki, Tabata Marayama Dos Santos, Sara Sumie Sobral Hamaguchi, Suellen Karoline Moreira Bezerra, Fabio José Alencar Silva, Bianca Goulart Rezende, Fernanda Tenório Quirino Dos Santos Lopes, Clarice Rosa Olivo, Beatriz Mangueira Saraiva-Romanholo, Carla Máximo Prado, Edna Aparecida Leick, Christine Laure Marie Bourotte, Isabela Judith Martins Benseñor, Paulo Andrade Lotufo, Renato Fraga Righetti, Iolanda Fátima Lopes Calvo Tibério
Prolonged exposure to iron powder and other mineral dusts can threaten the health of individuals, especially those with COPD. The goal of this study was to determine how environmental exposure to metal dust from two different mining centers in Brazil affects lung mechanics, inflammation, remodeling and oxidative stress responses in healthy and elastase-exposed mice. This study divided 72 male C57Bl/6 mice into two groups, the summer group and the winter group. These groups were further divided into six groups: control, nonexposed (SAL); nonexposed, given elastase (ELA); exposed to metal powder at a mining company (SAL-L1 and ELA-L1); and exposed to a location three miles away from the mining company (SAL-L2 and ELA-L2) for four weeks...
April 21, 2024: Scientific Reports