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Venlafaxine

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https://www.readbyqxmd.com/read/28742292/effects-of-a-course-of-right-unilateral-ultrabrief-pulse-electroconvulsive-therapy-combined-with-venlafaxine-on-insomnia-symptoms-in-elderly-depressed-patients
#1
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Mary Anne Riley, Laryssa McCloud, Charles H Kellner
OBJECTIVE: Antidepressant medications have a variety of effects on sleep, apart from their antidepressant effects. It is unknown whether electroconvulsive therapy (ECT) has effects on perceived sleep in depressed patients. This secondary analysis examines the effects of ECT on perceived sleep, separate from its antidepressant effects. METHODS: Elderly patients with major depressive disorder, as defined by DSM-IV, received open-label high-dose, right unilateral ultrabrief pulse ECT, combined with venlafaxine, as part of participating in phase 1 of the National Institute of Mental Health-supported study Prolonging Remission in Depressed Elderly (PRIDE)...
July 18, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28735366/further-validation-of-the-affective-bias-test-for-predicting-antidepressant-and-pro-depressant-risk-effects-of-pharmacological-and-social-manipulations-in-male-and-female-rats
#2
Justyna K Hinchcliffe, Sarah A Stuart, Michael Mendl, Emma S J Robinson
RATIONALE: Affective biases are hypothesised to contribute to the cause and treatment of mood disorders. We have previously found that affective biases, associated with learning and memory, are observed following acute treatments with a range of antidepressant and pro-depressant manipulations. OBJECTIVE: This study aimed to test if similar biases are observed in male and female Sprague Dawley (SD) rats. We also test whether the stress hormone, corticosterone, induces a negative bias in the affective bias test (ABT) consistent with its putative role in the development of depression...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28718182/driving-under-the-influence-of-antidepressants-a-systematic-review-and-update-of-the-evidence-of-experimental-and-controlled-clinical-studies
#3
Alexander Brunnauer, Gerd Laux
Introduction This review provides an update of experimental and clinical studies on the effects of antidepressants on driving performance. Methods A systematic literature search on the PubMed database (1980-2016) was performed. Results Twenty-eight studies could be included in this review, whereas only 5 studies investigated driving performance under antidepressants in patients. Most tri- and tetracyclics have acute deleterious effects on driving performance that, except for mianserin, attenuate after subchronic use...
July 17, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28708853/selective-serotonin-reuptake-inhibitors-and-venlafaxine-in-pregnancy-changes-in-drug-disposition
#4
Andreas Austgulen Westin, Malin Brekke, Espen Molden, Eirik Skogvoll, Olav Spigset
BACKGROUND: Pregnancy may cause changes in drug disposition. The clinical consequences may be profound and even counterintuitive; in some cases pregnant women may need more than twice their usual drug dose in order to maintain therapeutic drug levels. For antidepressants, evidence on drug disposition in pregnancy is scarce. The aim of this study was to determine the effects of pregnancy on serum levels of selective serotonin reuptake inhibitors (SSRIs) and venlafaxine in a large and naturalistic patient material, in order to provide tentative dose recommendations for pregnant women...
2017: PloS One
https://www.readbyqxmd.com/read/28707591/new-generation-non-ssri-antidepressants-therapeutic-drug-monitoring-and-pharmacological-interactions-part-1-snris-smss-saris
#5
Roberto Mandrioli, Michele Protti, Laura Mercolini
BACKGROUND: New-generation antidepressants (NGAs) are the latest additions to the clinician's arsenal in the fight against depression. After the introduction of selective serotonin reuptake inhibitors (SSRIs), a plethora of other groups followed, identified by their main mechanisms of activity: serotonin and norepinephrine reuptake inhibitors (SNRI); serotonin modulators and stimulators (SMS); serotonin antagonists and reuptake inhibitors (SARI); noradrenergic and selective serotonergic antidepressants (NaSSA); norepinephrine reuptake inhibitors (NeRI); serotonin, norepinephrine and dopamine reuptake inhibitors (SNDRI) or triple reuptake inhibitors (TRI); and melatonin and serotonin agonists (MaSA)...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28698115/interleukin-17-selectively-predicts-better-outcomes-with-bupropion-ssri-combination-novel-t-cell-biomarker-for-antidepressant-medication-selection
#6
Manish K Jha, Abu Minhajuddin, Bharathi Gadad, Tracy L Greer, Taryn L Mayes, Madhukar H Trivedi
BACKGROUND: Interleukin 17 (IL-17) is produced by highly inflammatory Th17 cells and has been implicated in pathophysiology of depression. IL-17 putatively disrupts the blood brain barrier and affects dopamine synthesis whereas dopamine has been shown to decrease Th17 cell-mediated immune response. Nevertheless, whether IL-17 can predict differential treatment outcome with antidepressants modulating dopaminergic transmission is unknown. METHODS: IL-17 and other T cell and non-T cell markers (Th1, Th2 and non-T cell markers) were measured with the Bioplex Pro™ human cytokine 27-plex kit in the Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided baseline plasma and were treated with either bupropion plus escitalopram (bupropion-SSRI), escitalopram plus placebo (SSRI monotherapy), or venlafaxine plus mirtazapine (n=166)...
July 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28686941/diffusion-and-sorption-of-organic-micropollutants-in-biofilms-with-varying-thicknesses
#7
Elena Torresi, Fabio Polesel, Kai Bester, Magnus Christensson, Barth F Smets, Stefan Trapp, Henrik R Andersen, Benedek Gy Plósz
Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly influence partitioning kinetics. In this study, the diffusion and the sorption of 23 micropollutants were investigated in novel moving bed biofilm reactor (MBBR) carriers with controlled biofilm thickness (50, 200 and 500 μm) using targeted batch experiments (initial concentration = 1 μg L(-1), for X-ray contrast media 15 μg L(-1)) and mathematical modelling...
June 14, 2017: Water Research
https://www.readbyqxmd.com/read/28685967/rapid-solid-phase-extraction-coupled-with-gc-ms-method-for-the-determination-of-venlafaxine-in-rat-plasma-application-to-the-drug-drug-pharmacokinetic-interaction-study-of-venlafaxine-combined-with-fluoxetine
#8
Lin Song, Zhen Zheng, Chen Liang, Xiujuan Chen, Runsheng Zhang, Zhanying Hong, Yifeng Chai
A rapid and sensitive gas chromatography with mass spectrometry method for the determination of venlafaxine in rat plasma has been developed and applied to a drug-drug interaction study of fluoxetine on pharmacokinetics of venlafaxine in rats. Rat plasma was spiked with 2% aqueous ammonia before subjected to preactivated C18 solid-phase extraction columns and eluted with methanol. No endogenous interferences were observed under optimal condition. The calibration curve was linear (R(2)  = 0.9994) in the range of 10-1000 ng/mL...
July 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28679194/acute-urinary-retention-after-venlafaxine-use
#9
Şaban Oğuz Demirdöğen, Esen Yıldırım Demirdöğen, Şenol Adanur
We describe a case of lower urinary system symptoms (LUSSs) and acute urinary retention that developed after treatment with a low dose of venlafaxine. A 48-year-old male patient was admitted to our clinic because of difficulty urinating, an intermittent stream, and trickling at the end of urination, together with urinary retention that had started about 45 days ago. The patient had been taking venlafaxine for the previous 6 months. The drug had been prescribed by the psychiatry department for a diagnosis of major depression, and the dose had been increased from 75 mg/day to 150 mg/day 1...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28677828/vortioxetine-for-depression-in-adults
#10
REVIEW
Markus Koesters, Giovanni Ostuzzi, Giuseppe Guaiana, Johanna Breilmann, Corrado Barbui
BACKGROUND: Major depressive disorder is a common mental disorder affecting a person's mind, behaviour and body. It is expressed as a variety of symptoms and is associated with substantial impairment. Despite a range of pharmacological and non-pharmacological treatment options, there is still room for improvement of the pharmacological treatment of depression in terms of efficacy and tolerability. The latest available antidepressant is vortioxetine. It is assumed that vortioxetine's antidepressant action is related to a direct modulation of serotonergic receptor activity and inhibition of the serotonin transporter...
July 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28672149/enantiomeric-profiling-of-a-chemically-diverse-mixture-of-chiral-pharmaceuticals-in-urban-water
#11
S Evans, J Bagnall, B Kasprzyk-Hordern
Due to concerns regarding the release of pharmaceuticals into the environment and the understudied impact of stereochemistry of pharmaceuticals on their fate and biological potency, we focussed in this paper on stereoselective transformation pathways of selected chiral pharmaceuticals (16 pairs) at both microcosm (receiving waters and activated sludge wastewater treatment simulating microcosms) and macrocosm (wastewater treatment plant (WWTP) utilising activated sludge technology and receiving waters) scales in order to test the hypothesis that biodegradation of chiral drugs is stereoselective...
June 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28663124/comparative-evaluation-of-vortioxetine-as-a-switch-therapy-in-patients-with-major-depressive-disorder
#12
Michael E Thase, Natalya Danchenko, Melanie Brignone, Ioana Florea, Francoise Diamand, Paula L Jacobsen, Eduard Vieta
Switching antidepressant therapy is a recommended strategy for depressed patients who neither respond to nor tolerate an initial pharmacotherapy course. This paper reviews the efficacy and tolerability of switching to vortioxetine. All three published studies of patients with major depressive disorder (MDD) switched from SSRI/SNRI therapy to vortioxetine due to lack of efficacy or tolerability were selected. Vortioxetine was evaluated versus agomelatine directly (REVIVE) and versus sertraline, venlafaxine, bupropion, and citalopram in an indirect treatment comparison (ITC) from switch studies retrieved in a literature review...
June 26, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28659991/bupropion-maintenance-treatment-in-refractory-bipolar-depression-a-case-report
#13
Julia Dehning, Heinz Grunze, Armand Hausmann
BACKGROUND: The optimal duration of antidepressant treatment in bipolar depression appears to be controversial due to a lack of quality evidence, and guideline recommendations are either vague or contradictive. This is especially true for second line treatments such as bupropion that had not been subject to rigourous long term studies in Bipolar Disorder. CASE PRESENTATION: We report the case of a 75 year old woman who presented with treatment refractory bipolar depression...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/28657697/vascular-risk-factors-in-older-patients-with-depression-outcome-of-electroconvulsive-therapy-versus-medication
#14
Harm-Pieter Spaans, Rob M Kok, Filip Bouckaert, Julia F Van Den Berg, Orlaith C Tunney, Pascal Sienaert, Esmée Verwijk, King H Kho, Max L Stek
OBJECTIVE: Research suggests that in depression, vascular burden predicts a lower efficacy for medication (MED) and a more favourable outcome for electroconvulsive therapy (ECT). Therefore, we investigated the influence of the following vascular risk factors (VRF): hypercholesterolemia, hypertension, smoking, diabetes mellitus, cardiovascular disease, and cerebral vascular accident/transient ischemic attack, on remission from major depression after ECT versus MED. METHODS: The study sample consisted of 81 inpatients with a DSM-IV unipolar major depression diagnosis (mean age 72...
June 28, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28649145/do-ssris-and-snris-reduce-the-frequency-and-or-severity-of-hot-flashes-in-menopausal-women
#15
Chris Stubbs, Lisa Mattingly, Steven A Crawford, Elizabeth A Wickersham, Jessica L Brockhaus, Laine H McCarthy
CLINICAL QUESTION: In menopausal women who experience regular hot flashes, does treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) reduce the frequency and/or severity of hot flashes? ANSWER: Yes. Review of the literature suggests that treatment with SSRIs or SNRIs reduces the frequency and severity of hot flashes in menopausal and post-menopausal women. Studies demonstrated that paroxetine (Paxil), citalopram (Celexa) and escitolapram (Lexapro) were the most effective SSRIs, and venlafaxine (Effexor) was the most effective first line SNRI, with desvenlafaxine as a second option...
May 2017: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/28648913/the-effects-of-analgesics-on-central-processing-of-tonic-pain-a%C3%A2-cross-over-placebo-controlled-study
#16
Dina Lelic, Tine M Hansen, Esben B Mark, Anne E Olesen, Asbjørn M Drewes
INTRODUCTION: Opioids and antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) are recognized as analgesics to treat moderate to severe pain, but the central mechanisms underlying their analgesia remain unclear. This study investigated how brain activity at rest and exposed to tonic pain is modified by oxycodone (opioid) and venlafaxine (SNRI). METHODS: Twenty healthy males were included in this randomized, cross-over, double-blinded study. 61-channel electroencephalogram (EEG) was recorded before and after five days of treatment with placebo, oxycodone (10 mg extended release b...
June 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28645134/-arterial-hyper-and-hypotension-associated-with-psychiatric-medications-a-risk-assessment-based-on-the-summaries-of-product-characteristics-smpcs
#17
Roland W Freudenmann, Ninja Freudenmann, Bartosz Zurowski, Carlos Schönfeldt-Lecuona, Ludwig Maier, Roland E Schmieder, Christian Lange-Asschenfeldt, Maximilian Gahr
Introduction Psychiatric medications are well-known triggers of clinically relevant blood pressure changes. Therefore, we aimed at creating ranking lists for their risk of causing arterial hyper- or hypotension. Methods We analyzed 784 Summaries of Product characteristics (SmPCs, available online from "Rote Liste" or "Gelbe Liste" websites) from 105 psychiatric medications registered in adult psychiatry in Germany and extracted the standardized reported risks of increasing or decreasing arterial blood pressure...
June 23, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28627776/the-comt-val-108-158-met-genetic-polymorphism-can-not-be-recommended-as-a-biomarker-of-prediction-of-venlafaxine-efficacy-in-patients-treated-in-psychiatric-settings
#18
Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft
The antidepressant venlafaxine is known to increase the turn-over of cerebral monoamines, which are catabolized by the cathecol-O-methyltransferase (COMT). The COMT (Val108/158Met, rs4680) genetic polymorphism affects the cerebral COMT activity. But whether this genetic polymorphism is associated with response to venlafaxine remains unclear. We assessed the impact of the COMT Val(108/158)Met, rs4680 genetic polymorphism on the efficacy of venlafaxine in depressed patients. This study was nested in the METADAP cohort, a real-world naturalistic treatment study in psychiatric settings...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28622660/assessing-the-effects-of-the-antidepressant-venlafaxine-to-fathead-minnows-exposed-to-environmentally-relevant-concentrations-over-a-full-life-cycle
#19
Joanne L Parrott, Chris D Metcalfe
Venlafaxine is an antidepressant drug that has been detected in municipal wastewater effluents at low μg/L concentrations. To assess the potential of this compound to affect the survival, development and reproductive capacity of fish, we exposed fathead minnow (Pimephales promelas) over a full lifecycle in a flow-through system to nominal venlafaxine concentrations of 0.88, 8.8, and 88 μg/L. Mean measured venlafaxine concentrations in these treatments were 1.0, 9.3 and 75 μg/L. During the 167-168 d exposure, no significant changes were observed in survival, or the weights and lengths of fathead minnows...
June 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28620858/toxicity-assessment-of-five-emerging-pollutants-alone-and-in-binary-or-ternary-mixtures-towards-three-aquatic-organisms
#20
Carole Di Poi, Katherine Costil, Valérie Bouchart, Marie-Pierre Halm-Lemeille
Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ)...
June 15, 2017: Environmental Science and Pollution Research International
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