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Venlafaxine

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https://www.readbyqxmd.com/read/28627776/the-comt-val-108-158-met-genetic-polymorphism-can-not-be-recommended-as-a-biomarker-of-prediction-of-venlafaxine-efficacy-in-patients-treated-in-psychiatric-settings
#1
Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft
The antidepressant venlafaxine is known to increase the turn-over of cerebral monoamines, which are catabolized by the cathecol-O-methyltransferase (COMT). The COMT (Val108/158Met, rs4680) genetic polymorphism affects the cerebral COMT activity. But whether this genetic polymorphism is associated with response to venlafaxine remains unclear. We assessed the impact of the COMT Val(108/158)Met, rs4680 genetic polymorphism on the efficacy of venlafaxine in depressed patients. This study was nested in the METADAP cohort, a real-world naturalistic treatment study in psychiatric settings...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28622660/assessing-the-effects-of-the-antidepressant-venlafaxine-to-fathead-minnows-exposed-to-environmentally-relevant-concentrations-over-a-full-life-cycle
#2
Joanne L Parrott, Chris D Metcalfe
Venlafaxine is an antidepressant drug that has been detected in municipal wastewater effluents at low μg/L concentrations. To assess the potential of this compound to affect the survival, development and reproductive capacity of fish, we exposed fathead minnow (Pimephales promelas) over a full lifecycle in a flow-through system to nominal venlafaxine concentrations of 0.88, 8.8, and 88 μg/L. Mean measured venlafaxine concentrations in these treatments were 1.0, 9.3 and 75 μg/L. During the 167-168 d exposure, no significant changes were observed in survival, or the weights and lengths of fathead minnows...
June 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28620858/toxicity-assessment-of-five-emerging-pollutants-alone-and-in-binary-or-ternary-mixtures-towards-three-aquatic-organisms
#3
Carole Di Poi, Katherine Costil, Valérie Bouchart, Marie-Pierre Halm-Lemeille
Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ)...
June 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28606295/-diagnosing-and-treating-post-traumatic-stress-disorder
#4
Cæcilie Böck Buhmann, Henrik Steen Andersen
The post-traumatic stress disorder (PTSD) diagnosis has undergone large developments. With the changes in DSM-5 and the proposed changes in ICD-11, the two systems move in different directions. Treatment for PTSD is developing, but the evidence for the effect is lacking behind. Trauma-focused cognitive behavioural therapy and eye movement desensitization and reprocessing remain first choice. Pharmacotherapy is secondary. There is evidence for the effect of paroxetine, venlafaxine and fluoxetine and less so for sertraline...
June 12, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28598899/long-term-function-and-psychosocial-outcomes-with-venlafaxine-extended-release-75-225%C3%A2-mg-day-versus-placebo-in-the-prevent-study
#5
Koichiro Watanabe, Michael E Thase, Toshiaki Kikuchi, Takashi Tsuboi, Yuko Asami, Elizabeth Pappadopulos, Min Zhang, Matthieu Boucher, Susan Kornstein
This post-hoc analysis evaluated long-term psychosocial outcomes in patients with recurrent major depressive disorder treated with venlafaxine extended release (ER) 75-225 mg/day or placebo. Patients who responded to 10-week venlafaxine ER 75-300 mg/day treatment and maintained response through a 6-month continuation treatment were assigned randomly to venlafaxine ER or placebo maintenance-phase treatment. Data from responders to acute and continuation venlafaxine ER 75-225 mg/day treatment were analyzed during 12-month maintenance treatment while receiving venlafaxine ER of up to 225 mg/day...
June 8, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28574114/venlafaxine-intoxication-with-development-of-takotsubo-cardiomyopathy-successful-use-of-extracorporeal-life-support-intravenous-lipid-emulsion-and-cytosorb%C3%A2
#6
Ines Schroeder, Michael Zoller, Matthias Angstwurm, Felix Kur, Lorenz Frey
We describe a young patient who ingested 18 g (240 times the daily therapeutic dose) of venlafaxine in a suicide attempt. She developed severe cardiomyopathy in a takotsubo distribution causing cardiogenic shock and multi-organ dysfunction syndrome (MODS). She was successfully treated with intravenous lipid emulsion (ILE), extracorporeal life support (ECLS) and CytoSorb®. This is remarkable as, to the best of the authors' knowledge, this is the highest amount of venlafaxine intake seen in the literature with a nonfatal outcome...
May 23, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28567697/dopaminergic-mechanisms-in-memory-consolidation-and-antidepressant-reversal-of-a-chronic-mild-stress-induced-cognitive-impairment
#7
Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Ewa Litwa, Monika Niemczyk, Katarzyna Tota-Glowczyk, Paul Willner
Cognitive deficits in depression can be modelled using the novel object recognition (NOR) test, performance in which is impaired by chronic mild stress (CMS). We aimed to examine the involvement of mesocorticolimbic DA terminal regions, and to establish the substrate for CMS-induced impairment of NOR and its reversal by chronic antidepressant treatment. In experiments 1 and 2, we examined the effect of infusions into medial PFC, dorsal hippocampus (HPC), and nucleus accumbens (NAc) shell of D1 and D2 antagonists and D3 agonist, which were predicted to impair NOR with a short (1 h) delay, and of D1 and D2 agonists and D3 antagonist, which were predicted to facilitate NOR with a long (24 h) delay...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28566959/metabolic-effects-of-antidepressant-treatment
#8
Özlem Olguner Eker, Saliha Özsoy, Baki Eker, Hatice Doğan
INTRODUCTION: This study aimed to investigate body measurements, glucose-insulin metabolism, and lipid profile in patients with anxiety and depressive symptoms and also the effects of antidepressant drugs on these metabolic parameters. METHODS: The study included 40 outpatients and 32 healthy controls. The patients received antidepressant treatment (sertraline, escitalopram, fluoxetine, and venlafaxine) for 8 weeks. Body measurements were performed, and lipid, fasting blood glucose, and insulin levels were measured before and after treatment in patients and once in healthy controls...
March 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28557178/impact-of-etiology-and-duration-of-pain-on-pharmacological-treatment-effects-in-painful-polyneuropathy
#9
S H Sindrup, J Holbech, D Demant, N B Finnerup, F W Bach, T S Jensen
BACKGROUND: The pharmacological treatments for painful polyneuropathy have not changed much for more than a decade, and less than half of the patients obtain adequate pain relief with first line treatments. Therefore, patient-specific factors which could predict drug response are searched for. METHODS: We analysed data from four published, randomized, controlled trials of drugs in painful polyneuropathy to see if diabetic etiology and duration of neuropathic pain had an impact on drug efficacy...
May 30, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28555718/bone-turnover-with-venlafaxine-treatment-in-older-adults-with-depression
#10
Kerri S Rawson, David Dixon, Roberto Civitelli, Tim R Peterson, Benoit H Mulsant, Charles F Reynolds, Eric J Lenze
OBJECTIVES: Epidemiologic data suggest older adults receiving serotonergic antidepressants may have accelerated bone loss. We examined bone turnover marker changes and patient-level variables associated with these changes in older adults receiving protocolized antidepressant treatment. DESIGN: Open-label, protocolized treatment study. SETTING: Medical centers in Pittsburgh, St Louis, and Toronto. PARTICIPANTS: Older adults with major depression (N = 168)...
May 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28554532/efficacy-of-venlafaxine-in-neuropathic-pain-a-narrative-review-of-optimized-treatment
#11
REVIEW
Anne-Priscille Trouvin, Serge Perrot, Célia Lloret-Linares
PURPOSE: The prevalence of neuropathic pain is high in the general population, and high priority is given to the management of this pain condition. The treatment of neuropathic pain remains challenging, despite the publication of national and international recommendations. The purpose of this narrative review of venlafaxine (VLX) is to provide a better knowledge of the pharmacology of this drug and a clearer view of its efficacy and tolerability in neuropathic pain. METHODS: Two independent reviewers searched PubMed with the following search terms: serotonin and noradrenalin reuptake inhibitors OR VLX hydrochloride AND pain...
June 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28547577/pramipexole-overdose-associated-with-visual-hallucinations-agitation-and-myoclonus
#12
Adeline Cardon-Dunbar, Tom Robertson, Michael S Roberts, Geoffrey K Isbister
INTRODUCTION: Pramipexole is a dopamine D2 receptor agonist used to treat idiopathic Parkinson's disease and primary restless legs syndrome. There is limited information on pramipexole overdose. CASE REPORT: A 59-year-old male ingested 3 mg pramipexole, 2250 mg venlafaxine, 360 mg mirtazapine, with suicidal intent. He presented alert, had normal vital observations and normal pupillary reflexes. He was mildly agitated, reported visual hallucinations and was given 5 mg diazepam...
May 25, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28529072/rescue-of-il-1%C3%AE-induced-reduction-of-human-neurogenesis-by-omega-3-fatty-acids-and-antidepressants
#13
Alessandra Borsini, Silvia Alboni, Mark A Horowitz, Luis M Tojo, Giuseppe Cannazza, Kuan-Pin Su, Carmine M Pariante, Patricia A Zunszain
Both increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. We have previously described how interleukin-1 (IL-1) β, a pro-inflammatory cytokine increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. Here, using the same human in vitro model, we show how omega-3 (ω-3) polyunsaturated fatty acids and conventional antidepressants reverse this reduction in neurogenesis, while differentially affecting the kynurenine pathway...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#14
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28500130/a-seizure-induced-t8-burst-fracture-re-presenting-as-an-acute-abdomen
#15
Radford Arran James Smith, Nigel Poland, Simon Cope
A male aged 44 years presented to the emergency department with a 1-week history of intermittent right-sided abdominal pain radiating to the midline. Examination demonstrated a tender right upper quadrant with voluntary guarding and a low grade fever. One week previously, he had been admitted to hospital after an isolated, self-terminating seizure secondary to an deliberate venlafaxine overdose. His upper abdominal symptoms started immediately postseizure but at the time were attributed to musculoskeletal chest pain by the discharging team...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28490916/the-cannabis-withdrawal-syndrome-current-insights
#16
REVIEW
Udo Bonnet, Ulrich W Preuss
The cannabis withdrawal syndrome (CWS) is a criterion of cannabis use disorders (CUDs) (Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition) and cannabis dependence (International Classification of Diseases [ICD]-10). Several lines of evidence from animal and human studies indicate that cessation from long-term and regular cannabis use precipitates a specific withdrawal syndrome with mainly mood and behavioral symptoms of light to moderate intensity, which can usually be treated in an outpatient setting...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/28480819/should-a-routine-genotyping-of-cyp2d6-and-cyp2c19-genetic-polymorphisms-be-recommended-to-predict-venlafaxine-efficacy-in-depressed-patients-treated-in-psychiatric-settings
#17
Adela Taranu, Romain Colle, Florence Gressier, Khalil El Asmar, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft
AIM: The antidepressant venlafaxine (VEN) is metabolized by CYP2D6 and CYP2C19. The aim of this study was to assess the relevance of generalizing to daily practice the genotyping of CYP2D6 and CYP2C19 to predict VEN efficacy in depressed patients treated in psychiatric settings. PATIENTS & METHODS: This study was nested in a naturalistic cohort, with 206 patients requiring a new antidepressant treatment and genotyped for CYP2D6 *3, *4, *5 del, *6, *2xN, *10, *41 and CYP2C19 *2, *3, *4, *5, *17 alleles...
May 8, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28465217/antidepressants-induce-autophagy-dependent-nlrp3-inflammasome-inhibition-in-major-depressive-disorder
#18
Elísabet Alcocer-Gómez, Nieves Casas-Barquero, Matthew R Williams, Samuel L Romero-Guillena, Diego Cañadas-Lozano, Pedro Bullón, José Antonio Sánchez-Alcazar, José M Navarro-Pando, Mario D Cordero
Major Depressive Disorder (MDD, ICD-10: F-33) is a prevalent illness in which the pathogenic mechanism remains elusive. Recently an important role has been attributed to neuro-inflammation, and specifically the NLRP3-inflammasome complex, in the pathogenesis of MDD. This suggests a key role for immunomodulation as a key pathway in the treatment of this disorder. This study evaluates the involvement of nine common antidepressants in the NLRP3-inflammasome complex (fluoxetine, paroxetine, mianserin, mirtazapine, venlafaxine, desvenlafaxine, amitriptyline, imipramine and agomelatine), both in in vitro THP-1 cells stimulated by ATP, and in a stress-induced depressive animal or MDD patients...
May 2, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28456144/effects-of-venlafaxine-and-chronic-unpredictable-stress-on-behavior-and-hippocampal-neurogenesis-of-rat-dams
#19
Kristina Belovicova, Eszter Bogi, Romana Koprdova, Eduard Ujhazy, Mojmir Mach, Michal Dubovicky
OBJECTIVE: Epidemiological studies strongly support the theory that stressful life events play an important role in the etiology of depression. The mechanism of chronic stress induced depression involves a number of systems. Chronic stress represents a serious health issue especially during pregnancy and lactation. In this sensitive period, stress can lead to changes in emotion and cognitive behavior both of the mothers and the offspring. It is thus necessary to properly manage stress events during gestation...
February 15, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28449567/dose-dependent-course-of-hyperprolactinemic-and-normoprolactinemic-galactorrhea-induced-by-venlafaxine
#20
Mehmet Akif Camkurt, Gizem Gülpamuk, Ebru Fındiklı, Rengin Elve
Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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