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https://www.readbyqxmd.com/read/26092711/angiosarcoma-of-the-breast-a-new-therapeutic-approach
#1
Raffaella Benevento, Francesco Carafa, Domenico Di Nardo, Gianluca Pellino, Antonia Letizia, Marianna Taddeo, Antonio Gambardella, Silvestro Canonico, Antonio Santoriello
INTRODUCTION: Angiosarcomas are highly malignant endothelial cell tumors with poor prognosis. These can be due to breast cancer itself or to subsequent therapeutic modalities. No evidence-based guidelines exist concerning the ideal treatment of angiosarcomas. PRESENTATION OF THE CASE: We report the case of a 76-year-old woman who developed an exuberant and aggressive post radiation angiosarcoma of the breast and discuss different aspects of therapy for this disease...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/24660074/germinoma-with-involvement-of-midline-and-off-midline-intracranial-structures
#2
Monica Graciela Loto, Karina Danilowicz, Santiago González Abbati, Rafael Torino, Alejandro Misiunas
Germinomas are malignant intracranial germ tumors, usually found in suprasellar regions. Less than 10% are localized in off-middle structures, and synchronous involvement of both structures has only exceptionally been published. A case of an 18-year-old male patient with progressive right-sided hemiparesis and panhypopituitarism was reviewed. Brain MRI showed a solid mass involving pituitary and hypothalamus with thickening of pituitary stalk, high intensity lesions on T2-weighted imaging in left internal capsule, caudate nucleus, globus pallidus, and mild atrophy of the left internal capsule and cerebral peduncle...
2014: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/24371596/unusual-liver-locations-of-growing-teratoma-syndrome-in-ovarian-malignant-germ-cell-tumors
#3
Domenica Lorusso, Paola Malaguti, Ilaria Nausica Trivellizzi, Giovanni Scambia
► Growing teratoma syndrome (GTS) with unusual liver locations are described after fertility preserving surgery and chemotherapy treatment for mixed malignant ovarian germ cell tumors (MGCT). ► It's a rare syndrome of mixed malignant ovarian germ cell tumors and in both cases enlarged and growing liver masses appeared during cisplatin-etoposide-bleomicin (BEP) chemotherapy. ► Radiological exams (CT scan and MRI) were suggestive for secondary metastasis and serum markers became negative during chemotherapy...
2011: Gynecologic Oncology Case Reports
https://www.readbyqxmd.com/read/21936027/cell-therapy-for-fibrotic-interstitial-pulmonary-disease-experimental-study
#4
Rosa M Cabral, Érika Branco, Márcia Dos S Rizzo, Guilherme J Ferreira, Guilherme B Gregores, Vivian Y Samoto, Angelo J Stopiglia, Paulo C Maiorka, Emerson T Fioretto, Vera L Capelozzi, João B Borges, Susimeire Gomes, Marcelo A Beraldo, Carlos R R Carvalho, Maria A Miglino
Parte superior do formulário Digite um texto ou endereço de um site ou traduza um documento. The aim of this study is to evaluate the histological changes in lung parenchyma of pigs affected by interstitial lung disease induced after the infusion of bone marrow mononuclear cells (BMMCs). Ten female swines were submitted to pulmonary fibrosis induced by a single dose of intratracheal bleomicine sulfate. Animals were arranged into two groups: Group 1: induced-disease control and Group 2: cell therapy using BMMCs...
October 2011: Microscopy Research and Technique
https://www.readbyqxmd.com/read/21207456/cell-therapy-for-fibrotic-interstitial-pulmonary-disease-experimental-study
#5
Rosa M Cabral, Erika Branco, Márcia Dos S Rizzo, Guilherme J Ferreira, Guilherme B Gregores, Vivian Y Samoto, Angelo J Stopiglia, Paulo C Maiorka, Emerson T Fioretto, Vera L Capelozzi, João B Borges, Susimeire Gomes, Marcelo A Beraldo, Carlos R R Carvalho, Maria A Miglino
Parte superior do formulário Digite um texto ou endereço de um site ou traduza um documento. The aim of this study is to evaluate the histological changes in lung parenchyma of pigs affected by interstitial lung disease induced after the infusion of bone marrow mononuclear cells (BMMCs). Ten female swines were submitted to pulmonary fibrosis induced by a single dose of intratracheal bleomicine sulfate. Animals were arranged into two groups: Group 1: induced-disease control and Group 2: cell therapy using BMMCs...
January 4, 2011: Microscopy Research and Technique
https://www.readbyqxmd.com/read/20169671/neoadjuvant-chemotherapy-in-advanced-vulvar-cancer
#6
COMPARATIVE STUDY
Ana Patrícia Domingues, Fernando Mota, Marta Durão, Cristina Frutuoso, Natália Amaral, Carlos Freire de Oliveira
INTRODUCTION: Locally advanced tumors of the vulva represent approximately one third of all vulvar cancers. Therapeutic options include chemoradiation, radiotherapy, and neoadjuvant chemotherapy (NACT). MATERIALS AND METHODS: Analysis of 3 NACT schemes, bleomicine, paclitaxel, and 5-fluorouracil/cisplatin, used in patients with locally advanced vulvar tumors in a 12-year period. The following parameters were evaluated and compared between regimens: age, initial tumor size, inguinal involvement, histological type, toxicities, response to treatment, surgery performed after NACT, and overall survival...
February 2010: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/20058697/-a-case-of-rapidly-growing-inflammatory-myofibroblastic-tumor-in-the-lung
#7
Saiko Suetsugu, Hidetaka Yamamoto, Miiru Izumi, Koichi Takayama, Hiromasa Inoue, Yoichi Nakanishi
We report a case of a 28-year-old man with a dry cough and chest pain. Chest X-ray film showed a huge mass in the right lung field. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a huge mass which occupied most of the right thoracic cavity and invaded the superior vena cava, heart atrium and right pulmonary vein. Positron emission tomography (PET) showed metastasis of bone, right adrenal grand and lymph nodes. A tumor specimen was biopsied percutaneously, and the diagnosis was pathologically confirmed as an inflammatory myofibroblastic tumor...
December 2009: Nihon Kokyūki Gakkai Zasshi, the Journal of the Japanese Respiratory Society
https://www.readbyqxmd.com/read/19861578/macop-b-regimen-in-the-treatment-of-adult-langerhans-cell-histiocytosis-experience-on-seven-patients
#8
E Derenzini, M P Fina, V Stefoni, C Pellegrini, F Venturini, A Broccoli, L Gandolfi, S Pileri, S Fanti, E Lopci, P Castellucci, C Agostinelli, M Baccarani, P L Zinzani
BACKGROUND: Adult Langerhans cell histiocytosis (LCH) is a rare disease. The combination of vinblastine and prednisone, given in a 6-month course, is the standard of care but prospective randomized trials are lacking. PATIENTS AND METHODS: We report our monocentric experience in the treatment of seven adult patients with multisystem (MS) LCH (n = 3) or single-system multifocal (SS-m) LCH (n = 4) with the short-course intensive chemotherapy regimen methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone and bleomicin (MACOP-B)...
June 2010: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/19814687/cyclophosphamide-doxorubicin-vincristine-methotrexate-bleomicin-and-prednisone-plus-rituximab-in-untreated-young-patients-with-low-risk-age-adjusted-international-prognostic-index-0-1-diffuse-large-b-cell-lymphoma
#9
MULTICENTER STUDY
Enrico Derenzini, Vittorio Stefoni, Cinzia Pellegrini, Maria Paola Fina, Alessandro Broccoli, Filippo Venturini, Letizia Gandolfi, Stefano A Pileri, Maurizio Martelli, Maria Concetta Petti, Alessio Perrotti, Amalia De Renzo, Francesco Zaja, Michele Baccarani, Pier Luigi Zinzani
Young patients (aged 18-60 years) with good-prognosis diffuse large B-cell lymphoma (DLBCL) [0 and 1 risk factor according to age-adjusted international prognostic index (aa-IPI)] are distinguished from patients with poor-prognosis. Six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) in combination with rituximab achieved best results in young patients with low-risk DLBCL. We retrospectively analyzed the data of 82 patients (18-60 years) with untreated aa-IPI 0-1 DLBCL, from six Italian institutions, who underwent, between January 2002 and January 2007, rituximab-cyclophosphamide, doxorubicin, vincristine, methotrexate, bleomicin and prednisone (R-MACOP-B) therapy followed, in patients with bulky presentation, by 30-36 Gy involved-field radiation therapy (34 patients)...
November 2009: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/19145973/-genetic-transformation-of-the-mycelium-fungi-acremonium-chrysogenum
#10
A A Zhgun, M A Ivanova, A G Domracheva, M I Novak, M A El'darov, K G Skriabin, Iu E Bartoshevich
The system of transformation of heterologous genes under the method of agrobacterial transfer into Acremonium chrysogenum ATCC 11550 wild-type strains, natural producents of beta-lactam antibiotic cephalosporin C, and strains highly producing cephalosporin C 26/8 revealed by the multistage selection on its basis were developed. Vectors for agrobacterial transformation of A. chrysogenum containing expression cassettes of genes encoding resistance to geneticin (G418) and bleomicin (Zeocin) antibiotics under control of Ashbya gossypii and Saccharomyces cerevisiae TEF1 promoters were constructed...
November 2008: Prikladnaia Biokhimiia i Mikrobiologiia
https://www.readbyqxmd.com/read/17419922/-bleomicine-induced-dermatosis-flagellata
#11
Montse Fernández-Guarino, Lucía Pérez Carmona, Ernesto Muñoz Zato, Pedro Jaén Olasolo
No abstract text is available yet for this article.
April 7, 2007: Medicina Clínica
https://www.readbyqxmd.com/read/12872154/successful-paternity-with-microassisted-fertilization-after-total-body-irradiation-based-conditioning-for-autologous-bone-marrow-transplantation
#12
Nicola Petti, Gabriel Anghel, Mauro Schimberni, Luca De Rosa, Stefano Mancini, Giulio Metro, Barbara Villaccio, Ignazio Majolino
We present the case of a 20-year-old man with acute lymphoblastic leukemia who received chemotherapy with vincristine, adriamycin, cyclophosphamide, methotrexate, teniposide (VM-26), and bleomicin, followed by an autologous bone marrow transplantation after total body irradiation (TBI)-cyclophosphamide-based conditioning regimen. At 14 years, despite the severe oligoasthenospermia, he fathered a healthy child by assisted reproductive technique (ART) consisting in controlled ovarian hyperstimulation of the patient's wife, transvaginal ovum pick up and microinjection of the ovum with a previously isolated sperm cell from the patient (intracytoplasmatic sperm injection, ICSI)...
2003: Hematology Journal: the Official Journal of the European Haematology Association
https://www.readbyqxmd.com/read/9681219/a-prospective-clinical-trial-comparing-chemotherapy-radiotherapy-and-combined-therapy-in-the-treatment-of-early-stage-hodgkin-s-disease-with-bulky-disease
#13
RANDOMIZED CONTROLLED TRIAL
A Aviles, S Delgado
We performed a randomized clinical trial to assess the usefulness and toxicity of combined therapy compared with chemotherapy and radiotherapy in the treatment of early stage Hodgkin's disease with bulky disease as an adverse prognostic factor. Three-hundred and seven patients were enrolled into the study. They were randomized to receive either radiotherapy (extended field, generally mantle, 3500 cGy), or chemotherapy (adriamycin, bleomicin, vinblastine and dacarbazine: ABVD, 6 monthly) cycles or combined therapy (three cycles of ABVD, followed by irradiation therapy and three more cycles of chemotherapy)...
April 1998: Clinical and Laboratory Haematology
https://www.readbyqxmd.com/read/9678628/complete-response-to-chemotherapy-in-intra-abdominal-desmoplastic-small-round-cell-carcinoma-a-case-report
#14
M De Lena, M L Caruso, F Marzullo, S Mancarella, R Armentano, V Ventrella, M Guida
AIMS AND BACKGROUND: The authors report the case of a 23-year-old woman affected by intra-abdominal desmoplastic small round cell tumor (DSRCT) who obtained a complete response to multiagent chemotherapy. DSRCT is a rare, highly aggressive neoplasm generally arising in young people and seldom in females (about 20 cases described in the literature). METHODS: The patient underwent surgical resection of a large 15 x 15 cm mass located in the right lower abdominal quadrant, but after only 2 months later, two liver metastasis were noted...
May 1998: Tumori
https://www.readbyqxmd.com/read/9568097/sensitivity-of-anticancer-drugs-in-saos-2-cells-transfected-with-mutant-p53-varied-with-mutation-point
#15
L H Wang, K Okaichi, M Ihara, Y Okumura
A human osteosarcoma cell line, Saos-2, which is devoid of endogenous p53 gene, and clones of Saos-2 cells, which were transfected with wild type p53 or mutant p53 genes (123A, 143A, 175H and 273H), were observed for their surviving fraction after treatment with the commonly used anticancer drugs, cisplatin (CDDP), nimustine (ACNU), adriamicin (ADR) and bleomicin (BLM). The transfectants of the mutant 143A, 175H and 273H were significantly more resistant to CDDP than the transfectant of pOPI3 (expression plasmid only)...
January 1998: Anticancer Research
https://www.readbyqxmd.com/read/9380293/-colposcopic-monitoring-of-primary-chemotherapy-in-patients-with-locally-advanced-cancer-of-the-uterine-cervix
#16
REVIEW
M Moscarini, L Di Stefano, G Porzio, G Toro
OBJECTIVE: To evaluate colposcopy in the monitoring of patients affected by locally advanced cervix cancer treated with primary chemotherapy. MATERIALS AND METHODS: Eight patients (42-54 years old) affected by squamous cervical cancer locally advanced (stage FIGO IIa "bulky"/IIb/III) were treated with primary chemotherapy (cisplatin 50 mg/m2 vincristin 1 mg/m2 bleomicin 30 UI in 24 hours continuous infusion q 7 days for 3 cycles). Colposcopy was performed before chemotherapy, after the second cycle and at the end of chemotherapy...
July 1997: Minerva Ginecologica
https://www.readbyqxmd.com/read/8924792/-vulvar-cancer-the-therapeutic-aspects
#17
N Angelescu, D Cristian, S Voiculescu, A Nedelcu, I Florea, M Vlad, C Mateescu
Even though it has a low frequency (4 - 5%) compared to genital cancers, it has certain biological features represented by the possibility of multicentric localisation what performs on the dystrophic lesions, the presence of the inguinal nodes, the sensibility of the irradiation of the cancer and nodes and the efficacity of the treatment of the treatment of the bleomicine which request many therapeutical problems. Between 1985-1994, in Colţea Surgery Clinic there were operated 13 vulvar carcinoma, in women between 45-69 years old, in stages II (6), III (4) and IV b (3)...
March 1996: Chirurgia
https://www.readbyqxmd.com/read/8540131/acute-myeloblastic-leukemia-associated-with-mediastinal-nonseminomatous-germ-cell-tumors-report-on-two-cases
#18
A Berruti, E Pazè, E Fara, G Gorzegno, L Dogliotti
The demonstrated association with hematologic neoplasms may partially account for the poor survival of patients with mediastinal nonseminomatous germ cell tumors (MNSGCT) compared to patients with testicular and retroperitoneal counterparts. It has been shown that the median interval from the diagnosis of MNSGCT to the diagnosis of the hematologic disorders is 6 months, which contrasts sharply with the average time of 2 to 3 years for the development of therapy-related leukemias. The 2 cases herein described, 1 male and 1 female, developed acute M2 leukemia 4 and 2 years after the diagnosis of MNSGCT...
July 1995: Tumori
https://www.readbyqxmd.com/read/7672650/-pure-form-of-primary-ovarian-choriocarcinoma-report-of-a-case
#19
REVIEW
M Trigueros Velázquez, J A Sereno Coló, J Villagrán Urive
Ovarian choriocarcinoma from the germ cells is a very rare malignant neoplasia. About the pure form, very few cases have been reported in medical literature. Ovarian choriocarcinoma may originate in three modalities. As primary choriocarcinoma associated to ovarian pregnancy, 2. As a metastatic ovarian carcinoma, from other organs, mainly the uterus, 3. As a primary tumour of germ cells with differentiation to trophoblastic structures. The latter grows in girls or in adult woman, generally young, where necessarily pregnancy has to be excluded...
August 1995: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/7022060/-lichen-planus-verrucosum-and-spinocellular-carcinoma
#20
A Leitão, A P Baptista, A A Vasconcelos
A case of lichen planus verrucosus of the legs in a 29 year old patient is presented by the authors. 18 years after the outset a squamous cell carcinoma giving rise to lymph node metastasis appeared on a lesion localized on the external side of the right leg. The chronic inflammation and the traumatism are the only carcinogenetic factors to be considered. In this case there were no antecedents of arsenic administration. The therapy with bleomicin and R.X. was effective. The review of the literature shows the extreme rarity of the malignant transformation of the lichen planus verrucose...
1981: Medicina Cutánea Ibero-latino-americana
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