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https://www.readbyqxmd.com/read/29047156/cyclophosphamide-induced-male-subfertility-in-mice-an-assessment-of-the-potential-benefits-of-maca-supplement
#1
A Y Onaolapo, B P Oladipo, O J Onaolapo
Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29046808/occurrence-and-reproductive-roles-of-hormones-in-seminal-plasma
#2
Jana Vitku, Lucie Kolatorova, Richard Hampl
Only 2-5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29045572/impaired-sperm-maturation-in-conditional-lcn6-knockout-mice
#3
Qianqian Yin, Jia Shen, Xiaofeng Wan, Qiang Liu, Yuchuan Zhou, Yonglian Zhang
Human LCN6, a lipocalin protein, exhibits predominant expression in epididymis and location on the sperm surface. However, the biological function of LCN6 in vivo remains unknown. Herein, we found that unlike human LCN6, mouse Lcn6 gene encoded two transcript variants that were both up regulated by androgen. Subsequently, we generated a conditional knockout mouse model to disrupt Lcn6 in the adult and investigate its function. In this model, spermatogenesis was normal and Lcn6 deficiency did not affect the natural birth rate of male mice or in vitro fertilization ability of their cauda epididymal sperm...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29044427/genomic-identification-expression-profiling-and-functional-characterization-of-catsper-channels-in-the-bovine
#4
Gillian P Johnson, Anne-Marie English, Sinead Cronin, David A Hoey, Kieran G Meade, Sean Fair
Cation channels of sperm (CatSper) are sperm-specific calcium channels with identified roles in the regulation of sperm function in humans, mice, and horses. We sought to employ a comparative genomics approach to identify conserved CATSPER genes in the bovine genome, and profile their expression in reproductive tissue. We hypothesized that CATSPER proteins expressed in bull testicular tissue mediates sperm hyperactivation and their rheotactic response in the reproductive tract of the cow. Bioinformatic analysis identified all four known CATSPER genes (CATSPER 1-4) in the bovine genome, and profiling by quantitative real-time polymerase chain reaction identified site-specific variation in messenger ribonucleic acid (mRNA) expression for all four genes along the reproductive tract of the bull...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29044420/characterization-of-a-novel-role-for-the-dynamin-mechanoenzymes-in-the-regulation-of-human-sperm-acrosomal-exocytosis
#5
Wei Zhou, Amanda L Anderson, Adrian P Turner, Geoffry N De Iuliis, Adam McCluskey, Eileen A McLaughlin, Brett Nixon
STUDY QUESTION: Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER: Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY: Completion of an acrosome reaction is a prerequisite for successful fertilization in all studied mammalian species. It follows that failure to complete this unique exocytotic event represents a common aetiology in the defective spermatozoa of male infertility patients that have failed IVF in a clinical setting...
October 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040955/protective-role-of-epigallocatechin-3-gallate-on-arsenic-induced-testicular-toxicity-in-swiss-albino-mice
#6
Pushpa Rani Guvvala, Janivara Parameswaraiah Ravindra, Chukkath Vijayan Rajani, Muniandy Sivaram, Sellappan Selvaraju
Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced testicular toxicity in Swiss albino mice. Thirty two adult male mice were randomly assigned to four groups (n=8). Group I served as control without test chemical. The group II received arsenic (200ppm) through drinking water, group III received only EGCG (20mg/kgb...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040583/taste-receptor-polymorphisms-and-male-infertility
#7
M Gentiluomo, L Crifasi, A Luddi, D Locci, R Barale, P Piomboni, D Campa
STUDY QUESTION: Are polymorphisms of taste receptor genes associated with male infertility? SUMMARY ANSWER: This study has showed the associations between three single nucleotide polymorphisms (SNPs) in taste receptors genes (TASR) and male infertility. WHAT IS KNOWN ALREADY: Recent studies showed the expression of taste receptors in the testis and in spermatozoa, suggesting their possible role in infertility. The vast genetic variability in taste genes results in a large degree of diversity in various human phenotypes...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040510/genomic-fragmentation-and-extrachromosomal-telomeric-repeats-impact-assessment-of-telomere-length-in-human-spermatozoa-quantitative-experiments-and-systematic-review
#8
P Kurjanowicz, S Moskovtsev, C Librach
STUDY QUESTION: Can differences in DNA isolation alter assessment of sperm telomere length (spTL) and do they account for conflicting results in the literature on spTL and male fertility? SUMMARY ANSWER: DNA isolation methods preferentially include or exclude short, extrachromosomal (EC) telomere-specific sequences that alter spTL measurements, and are responsible for a proportion of the disparity observed between investigations. WHAT IS KNOWN ALREADY: The relationship between spTL and male fertility has become an active area of research...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039229/exposure-to-allethrin-based-mosquito-coil-smoke-during-gestation-and-postnatal-development-affects-reproductive-function-in-male-offspring-of-rat
#9
Golla Madhubabu, Suresh Yenugu
The threat of zika virus looms throughout the world and the use of allethrin-based mosquito coils to prevent mosquito bites during and postpregnancy is on the rise. The aim of this study was to analyze the toxic effects of exposure to allethrin-based mosquito coil smoke in rats under conditions that reflect human settings. Pregnant female rats were exposed to mosquito coil smoke and same was continued to the male pups up to 111 days postparturition (21-day weaning plus up to 90 days postweaning). Increased oxidative stress, distorted antioxidant enzyme status, downregulation of genes involved in spermatogenesis, sperm maturation and steroidogenesis was observed...
July 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29038763/mouse-spermatozoa-with-higher-fertilization-rates-have-thinner-nuclei
#10
Daisuke Mashiko, Masahito Ikawa, Koichi Fujimoto
BACKGROUND: Although spermatozoa with normal morphology are assumed to have uniform fertilization ability, recent data show that even normal spermatozoa have considerable variation in their head shape which is associated with differences in fertilization ability. Appropriate quantitative indicators for good sperm morphology, however, remain unidentified. METHODS: Therefore, in an effort to identify such an indicator, we compared the nuclear contour of normal mouse spermatozoa by quantitative multivariate analysis using elliptic Fourier descriptors combined with principal component analysis...
2017: PeerJ
https://www.readbyqxmd.com/read/29037981/effect-of-incubation-temperature-after-devitrification-on-quality-parameters-in-human-sperm-cells
#11
Pamela Uribe, Christian Rojas, Juan Meriño, Fabiola Zambrano, Juana V Villegas, Favián Treulen, Rodrigo Boguen, Vladimir Isachenko, Evgenia Isachenko, Raúl Sánchez
Sperm cryopreservation is common in assisted reproduction laboratories, providing a therapeutic option for several clinical conditions. This process has been optimized; however, the effect of post-thaw incubation temperature has been poorly studied. This work analyzed the effect of incubation temperature after devitrification on human sperm quality. Spermatozoa from normozoospermic donors were cryopreserved by vitrification. After devitrification, the spermatozoa were separated into two aliquots: (i) incubated at room temperature (RT, 22-25 °C) and (ii) incubated at 37 °C...
October 13, 2017: Cryobiology
https://www.readbyqxmd.com/read/29037102/complete-hydatidiform-moles-are-composed-of-paternal-chromosomes-and-maternal-mitochondria
#12
Zijun Pan, Hirokazu Usui, Asuka Sato, Makio Shozu
Mitochondrial DNA (mtDNA) and genomic DNA are produced in separate subcellular compartments. Human mtDNA is transmitted via maternal transmission in general. Complete hydatidiform moles (CHMs) represent major trophoblastic diseases that are cytogenetically exceptional because the chromosomal genomic DNA is derived only from sperm cells, making them strikingly different from normal concepti. However, few reports have described the mtDNA-transmission pattern in hydatidiform moles. To evaluate mtDNA transmission in androgenetic CHMs, we compared the sequences of hypervariable regions in 16 trios sets of mtDNAs from maternal, paternal, and villous samples of androgenetic CHMs diagnosed by short tandem repeat-polymorphism analysis...
October 17, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29036474/casanova-a-multiclass-support-vector-machine-model-for-the-classification-of-human-sperm-motility-patterns
#13
Summer G Goodson, Sarah White, Alicia M Stevans, Sanjana Bhat, Chia-Yu Kao, Scott Jaworski, Tamara R Marlowe, Martin Kohlmeier, Leonard McMillan, Steven H Zeisel, Deborah A O'Brien
The ability to accurately monitor alterations in sperm motility is paramount to understanding multiple genetic and biochemical perturbations impacting normal fertilization. Computer-aided sperm analysis (CASA) of human sperm typically reports motile percentage and kinematic parameters at the population level, and uses kinematic gating methods to identify subpopulations such as progressive or hyperactivated sperm. The goal of this study was to develop an automated method that classifies all patterns of human sperm motility during in vitro capacitation following the removal of seminal plasma...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29031884/human-sperm-cryopreservation-in-cancer-patients-links-with-deprivation-and-mortality
#14
Chey G Dearing, Channa N Jayasena, Kevin Lindsay
Evidence is mounting for a relationship between human semen quality and environmental/lifestyle/socioeconomic factors including long term health outcomes such as mortality. The relationship between pre-freeze and post-thaw semen quality in cancer patients and these factors are unknown. Frozen semen from 217 cancer patients was thawed and analysed using a validated CASA method. Post-thaw quality was matched and compared with WHO semen analysis performed prior to storage. The English Indices of Deprivation 2010 were matched with patients and then examined for relationships with ejaculate pre-freeze and post-thaw semen quality...
October 11, 2017: Cryobiology
https://www.readbyqxmd.com/read/29031729/point-mutation-of-ffar1-abrogates-fatty-acid-dependent-insulin-secretion-but-protects-against-hfd-induced-glucose-intolerance
#15
Sibylle Sabrautzki, Gabriele Kaiser, Gerhard K H Przemeck, Felicia Gerst, Estela Lorza-Gil, Madhura Panse, Tina Sartorius, Miriam Hoene, Susan Marschall, Hans-Ulrich Häring, Martin Hrabě de Angelis, Susanne Ullrich
OBJECTIVE: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty acid-mediated insulin secretion, but in vivo experiments delivered controversial results regarding the function of FFAR1 in glucose homeostasis and liver steatosis. This study presents a new coisogenic mouse model carrying a point mutation in Ffar1 with functional consequence...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29030775/improvement-in-pregnancy-outcomes-in-couples-with-immunologically-male-infertility-undergoing-prednisolone-treatment-and-conventional-in-vitro-fertilization-preceded-by-sperm-penetration-assay-a-randomized-controlled-trial
#16
Ahmed M Taiyeb, Mundhir T Ridha-Albarzanchi, Shereen M Taiyeb, Zuhair A Kanan, Shahla K Alatrakchi, Michael E Kjelland, Saeeda A Muhsen-Alanssari
PURPOSE: Anti-sperm antibodies (ASA) in men impair not only sperm motility but also fertilization and conception. However, utilization of corticosteroids to suppress ASA has shown variable pregnancy outcomes. This controversy is also extended to include the usefulness of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in treatments of men with ASA. This study was therefore designed to define factors contributing to these inconsistent results. METHODS: Infertile men having ASA (n = 241) were randomly assigned for treatment with or without prednisolone for three cycles each of 21 days of their partner's menstrual cycles...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29026720/efficacy-of-embryo-transfer-on-day-2-versus-day-3-according-to-maternal-age-in-patients-with-normal-ovarian-response
#17
Jung-Woo Lee, Jeong-Ho Cha, Sun-Hee Shin, Yun-Jeong Kim, Seul-Ki Lee, Choon-Keun Park, Kyung-Ah Pak, Ji-Sung Yoon, Seo-Young Park
OBJECTIVE: Delaying embryo transfer (ET) enables us to select among the embryos available for transfer and is associated with positive effects on implantation and pregnancy outcomes. However, the optimal day for ET of human cleavage-stage embryos remains controversial. METHODS: A retrospective study of 3,124 in vitro fertilization/intracytoplasmic sperm injection cycles (2,440 patients) was conducted. We compared the effects of day 2 and 3 ET on rates of implantation and pregnancy outcomes between young maternal age (YMA; <38 years old, n=2,295) and old maternal age (OMA; ≥38 years old, n=829) patient groups...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29026718/the-association-of-follicular-fluid-volume-with-human-oolemma-stretchability-during-intracytoplasmic-sperm-injection
#18
Taketo Inoue, Yoshiki Yamashita, Yoshiko Tsujimoto, Shuji Yamamoto, Sayumi Taguchi, Kayoko Hirao, Mikiko Uemura, Kayoe Ikawa, Kazunori Miyazaki
OBJECTIVE: Oocyte degeneration often occurs after intracytoplasmic sperm injection (ICSI), and the risk factor is low-quality oocytes. The follicular fluid (FF) provides a crucial microenvironment for oocyte development. We investigated the relationships between the FF volume aspirated from individual follicles and oocyte retrieval, oocyte maturity, oolemma stretchability, fertilization, and development. METHODS: This retrospective study included data obtained from 229 ICSI cycles...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29025071/the-expression-characteristics-of-fam71d-and-its-association-with-sperm-motility
#19
Qian Ma, Yuchi Li, Manling Luo, Huan Guo, Shouren Lin, Jianbo Chen, Ye Du, Zhimao Jiang, Yaoting Gui
STUDY QUESTION: What are the features of FAM71D (Family with sequence similarity 71, member D) expression and is there an association between FAM71D expression and sperm motility? SUMMARY ANSWER: FAM71D, a novel protein exclusively expressed in the testis, is located in sperm flagella and is functionally involved in sperm motility. WHAT IS KNOWN ALREADY: Some testis-specific proteins have been reported as potential diagnostic biomarkers to evaluate the spermatogenesis process and sperm quality...
September 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29024992/formation-and-function-of-sperm-tail-structures-in-association-with-sperm-motility-defects
#20
Mari S Lehti, Anu Sironen
Male infertility is an increasing problem partly due to inherited genetic variations. Mutations in genes involved in formation of the sperm tail cause motility defects and thus male infertility. Therefore it is crucial to understand the protein networks required for sperm differentiation. Sperm motility is produced through activation of the sperm flagellum, which core structure, the axoneme, resembles motile cilia. In addition to this cytoskeletal axonemal structure sperm tail motility requires various accessory structures...
August 30, 2017: Biology of Reproduction
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