keyword
MENU ▼
Read by QxMD icon Read
search

waka

keyword
https://www.readbyqxmd.com/read/27919205/achieving-simplified-disease-activity-index-remission-in-patients-with-active-rheumatoid-arthritis-is-associated-with-subsequent-good-functional-and-structural-outcomes-in-a-real-world-clinical-setting-under-a-treat-to-target-strategy
#1
Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). METHODS: In this multicentre, prospective cohort study, T2T was implemented in rheumatoid arthritis patients with moderate-to-high disease activity. SDAI or clinical disease activity index was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity...
December 6, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27916192/long-term-outcome-of-bowel-function-for-110-consecutive-cases-of-hirschsprung-s-disease-comparison-of-the-abdominal-approach-with-transanal-approach-more-than-30years-in-a-single-institution-is-the-transanal-approach-truly-beneficial-for-bowel-function
#2
Shun Onishi, Kazuhiko Nakame, Kouji Yamada, Waka Yamada, Takafumi Kawano, Motoi Mukai, Tatsuru Kaji, Satoshi Ieiri
BACKGROUND: We compared the long-term outcomes of the bowel function (BF) in Hirschsprung's disease (HD) patients who underwent transanal endorectal pull-through (TA) with those who underwent the Soave-Denda (SD) procedure. METHODS: Patient data were collected from 1984 to 2015 from 110 HD patients who underwent definitive diagnosis and operation. The follow-up data were analyzed retrospectively. BF was evaluated according to the evacuation score (ES) of the Japan Society of Anorectal Malformation Study Group at 3, 5, 7, 9, and 11years of age...
December 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27894279/development-of-a-community-s-self-efficacy-scale-for-preventing-social-isolation-among-community-dwelling-older-people-mimamori-scale
#3
Etsuko Tadaka, Ayumi Kono, Eriko Ito, Yukiko Kanaya, Yuka Dai, Yuki Imamatsu, Waka Itoi
BACKGROUND: Among older people in developed countries, social isolation leading to solitary death has become a public health issue of vital importance. Such isolation could be prevented by monitoring at-risk individuals at the neighborhood level and by implementing supportive networks at the community level. However, a means of measuring community confidence in these measures has not been established. This study is aimed at developing the Community's Self-Efficacy Scale (CSES; Mimamori scale in Japanese) for community members preventing social isolation among older people...
November 28, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27882874/an-intermediate-vascular-tumour-between-kaposiform-hemangioendothelioma-and-tufted-angioma-with-regression-of-the-skin-lesion
#4
Teruhiko Makino, Waka Ishida, Takeru Hamashima, Megumi Mizawa, Masakiyo Sasahara, Tadamichi Shimizu
No abstract text is available yet for this article.
November 23, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27846756/simplified-disease-activity-index-remission-at-month-6-is-an-independent-predictor-of-functional-and-structural-remissions-at-month-12-during-abatacept-treatment-in-patients-with-rheumatoid-arthritis-a-multi-center-prospective-cohort-study-in-japan
#5
Hayato Yamazaki, Fumio Hirano, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Mari Kihara, Waka Yokoyama, Takahiko Sugihara, Kenji Nagasaka, Hiroyuki Hagiyama, Yoshinori Nonomura, Ryoko Sakai, Michi Tanaka, Ryuji Koike, Toshihiro Nanki, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To evaluate association of clinical remission at month 6 with functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis (RA). METHODS: This 12-month prospective, multicenter cohort study enrolled 168 patients with RA who started abatacept. Outcomes were assessed using composite measures, quality of life indices, and the van der Heijde-modified total Sharp score (mTSS). The logistic regression analysis was applied to identify factors associated with outcomes and their odds ratios (OR) with 95% confidence interval (95% CI)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27832865/ghrelin-improves-intestinal-mucosal-atrophy-during-parenteral-nutrition-an-experimental-study
#6
Waka Yamada, Tatsuru Kaji, Shun Onishi, Kazuhiko Nakame, Koji Yamada, Takafumi Kawano, Motoi Mukai, Masakazu Souda, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri
BACKGROUND/PURPOSE: Total parenteral nutrition (TPN) has been reported to be associated with mucosal atrophy of the small intestine. Ghrelin has hormonal, orexigenic, and metabolic activities. We investigated whether ghrelin improved intestinal mucosal atrophy using a TPN-supported rat model. METHODS: Rats underwent jugular vein catheterization and were divided into four groups: TPN alone (TPN), TPN plus low-dose ghrelin (TPNLG), TPN plus high-dose ghrelin (TPNHG), and oral feeding with normal chow (OF)...
September 17, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27829522/the-changing-profile-of-safe-techniques-for-the-insertion-of-a-central-venous-catheter-in-pediatric-patients-improvement-in-the-outcome-with-the-experiences-of-500-insertions-in-a-single-institution
#7
Tatsuru Kaji, Takafumi Kawano, Waka Yamada, Koji Yamada, Shun Onishi, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri, Hideo Takamatsu
BACKGROUND: The ability to safely insert a central venous catheter (CVC) is critical to avoid associated complications. The aim of this study was to explore appropriate technique to maintain the safety of pediatric patients during CVC. METHODS: We reviewed the surgical records of CVC insertion techniques and associated complications of 503 tunneled CVC insertions performed from 2000 to 2015. RESULTS: Two hundred thirty CVCs (45.7%) were inserted into the subclavian vein using the landmark technique for 10years (first period)...
September 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27810878/prebiotic-potential-of-l-sorbose-and-xylitol-in-promoting-the-growth-and-metabolic-activity-of-specific-butyrate-producing-bacteria-in-human-fecal-culture
#8
Tadashi Sato, Shiro Kusuhara, Wakae Yokoi, Masahiko Ito, Kouji Miyazaki
Dietary low-digestible carbohydrates (LDCs) affect gut microbial metabolism, including the production of short-chain fatty acids. The ability of various LDCs to promote butyrate production was evaluated in in vitro human fecal cultures. Fecal suspensions from five healthy males were anaerobically incubated with various LDCs. L-sorbose and xylitol markedly promoted butyrate formation in cultures. Bacterial 16S rRNA gene-based denaturing gradient gel electrophoresis analyses of these fecal cultures revealed a marked increase in the abundance of bacteria closely related to the species Anaerostipes hadrus or Anaerostipes caccae, or both, during enhanced butyrate formation from L-sorbose or xylitol...
November 2, 2016: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27781370/mechanically-induced-opening-closing-action-of-binaphthyl-molecular-pliers-digital-phase-transition-vs-continuous-conformational-change
#9
Taizo Mori, Daisuke Ishikawa, Yusuke Yonamine, Yoshihisa Fujii, Jonathan P Hill, Izumi Ichinose, Katsuhiko Ariga, Waka Nakanishi
Reversible dynamic control of structure is a significant challenge in molecular nanotechnology. Previously, we have reported a mechanically induced continuous (analog) conformational variation in an amphiphilic binaphthyl, where closing of 'molecular pliers' was achieved by compression of a molecular monolayer composed of these molecules at the air-water interface. In this work we report that a phase transition induced by an applied mechanical stress enables discontinuous 'digital' (1/0) opening of simple binaphthyl molecular pliers...
October 26, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27720736/the-effect-of-a-crunchy-pseudo-chewing-sound-on-perceived-texture-of-softened-foods
#10
Hiroshi Endo, Shuichi Ino, Waka Fujisaki
Elderly individuals whose ability to chew and swallow has declined are often restricted to unpleasant diets of very soft food, leading to a poor appetite. To address this problem, we aimed to investigate the influence of altered auditory input of chewing sounds on the perception of food texture. The modified chewing sound was reported to influence the perception of food texture in normal foods. We investigated whether the perceived sensations of nursing care foods could be altered by providing altered auditory feedback of chewing sounds, even if the actual food texture is dull...
October 5, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27715419/cosmopolitan-or-cryptic-species-a-case-study-of-capitella-teleta-annelida-capitellidae
#11
Shinri Tomioka, Tomohiko Kondoh, Waka Sato-Okoshi, Katsutoshi Ito, Keiichi Kakui, Hiroshi Kajihara
Capitella teleta Blake et al., 2009 is an opportunistic capitellid originally described from Massachusetts (USA), but also reported from the Mediterranean, NW Atlantic, and North Pacific, including Japan. This putatively wide distribution had not been tested with DNA sequence data; intraspecific variation in morphological characters diagnostic for the species had not been assessed with specimens from non-type localities, and the species status of the Japanese population(s) was uncertain. We examined the morphology and mitochondrial COI (cytochrome c oxidase subunit I) gene sequences of Capitella specimens from two localities (Ainan and Gamo) in Japan...
October 2016: Zoological Science
https://www.readbyqxmd.com/read/27703343/mortality-associated-with-bone-fractures-in-copd-patients
#12
Yasuhiro Yamauchi, Hideo Yasunaga, Yukiyo Sakamoto, Wakae Hasegawa, Hideyuki Takeshima, Hirokazu Urushiyama, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase
BACKGROUND AND OBJECTIVE: COPD is well known to frequently coexist with osteoporosis. Bone fractures often occur and may affect mortality in COPD patients. However, in-hospital mortality related to bone fractures in COPD patients has been poorly studied. This retrospective study investigated in-hospital mortality of COPD patients with bone fractures using a national inpatient database in Japan. METHODS: Data of COPD patients admitted with bone fractures, including hip, vertebra, shoulder, and forearm fractures to 1,165 hospitals in Japan between July 2010 and March 2013, were extracted from the Diagnosis Procedure Combination database...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27694899/apobec3a-associates-with-human-papillomavirus-genome-integration-in-oropharyngeal-cancers
#13
S Kondo, K Wakae, N Wakisaka, Y Nakanishi, K Ishikawa, T Komori, M Moriyama-Kita, K Endo, S Murono, Z Wang, K Kitamura, T Nishiyama, K Yamaguchi, S Shigenobu, M Muramatsu, T Yoshizaki
The prevalence of human papillomavirus (HPV)-related oropharyngeal cancers has been increasing in developed countries. We recently demonstrated that members of the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) family, which are antiviral factors, can induce hypermutation of HPV DNA in vitro. In the present study, we found numerous C-to-T and G-to-A hypermutations in the HPV16 genome in oropharyngeal cancer (OPC) biopsy samples using differential DNA denaturation PCR and next-generation sequencing...
October 3, 2016: Oncogene
https://www.readbyqxmd.com/read/27651372/the-administration-of-ghrelin-improved-hepatocellular-injury-following-parenteral-feeding-in-a-rat-model-of-short-bowel-syndrome
#14
Shun Onishi, Tatsuru Kaji, Waka Yamada, Kazuhiko Nakame, Tomoe Moriguchi, Koushirou Sugita, Koji Yamada, Takafumi Kawano, Motoi Mukai, Masakazu Souda, Sohsuke Yamada, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri
PURPOSE: Long-term parenteral nutrition following massive bowel resection causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). IFALD includes two different states, cholestasis and steatosis, which represents a life-threatening complication. The previous reports have shown the protective role of ghrelin in the liver. The aim of this study was to evaluate the effects of the administration of ghrelin in the liver in a parenterally fed rat model of short bowel syndrome (SBS)...
September 20, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27626826/long-term-effects-of-radiation-exposure-and-metabolic-status-on-telomere-length-of-peripheral-blood-t-cells-in-atomic-bomb-survivors
#15
Kengo Yoshida, Munechika Misumi, Yoshiko Kubo, Mika Yamaoka, Seishi Kyoizumi, Waka Ohishi, Tomonori Hayashi, Yoichiro Kusunoki
In a series of studies of atomic bomb survivors, radiation-dose-dependent alterations in peripheral T-cell populations have been reported. For example, reduced size in naïve T-cell pools and impaired proliferation ability of T cells were observed. Because these alterations are also generally observed with human aging, we hypothesized that radiation exposure may accelerate the aging process of the T-cell immune system. To further test this hypothesis, we conducted cross-sectional analyses of telomere length, a hallmark of cellular aging, of naïve and memory CD4 T cells and total CD8 T cells in the peripheral blood of 620 atomic bomb survivors as it relates to age and radiation dose, using fluorescence in situ hybridization with flow cytometry...
September 14, 2016: Radiation Research
https://www.readbyqxmd.com/read/27541964/supramolecular-differentiation-for-construction-of-anisotropic-fullerene-nanostructures-by-time-programmed-control-of-interfacial-growth
#16
Partha Bairi, Kosuke Minami, Jonathan P Hill, Waka Nakanishi, Lok Kumar Shrestha, Chao Liu, Koji Harano, Eiichi Nakamura, Katsuhiko Ariga
Supramolecular assembly can be used to construct a wide variety of ordered structures by exploiting the cumulative effects of multiple noncovalent interactions. However, the construction of anisotropic nanostructures remains subject to some limitations. Here, we demonstrate the preparation of anisotropic fullerene-based nanostructures by supramolecular differentiation, which is the programmed control of multiple assembly strategies. We have carefully combined interfacial assembly and local phase separation phenomena...
September 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27541825/metabolic-profile-as-a-potential-modifier-of-long-term-radiation-effects-on-peripheral-lymphocyte-subsets-in-atomic-bomb-survivors
#17
Kengo Yoshida, Eiji Nakashima, Seishi Kyoizumi, Masayuki Hakoda, Tomonori Hayashi, Ayumi Hida, Waka Ohishi, Yoichiro Kusunoki
Immune system impairments reflected by the composition and function of circulating lymphocytes are still observed in atomic bomb survivors, and metabolic abnormalities including altered blood triglyceride and cholesterol levels have also been detected in such survivors. Based on closely related features of immune and metabolic profiles of individuals, we investigated the hypothesis that long-term effects of radiation exposure on lymphocyte subsets might be modified by metabolic profiles in 3,113 atomic bomb survivors who participated in health examinations at the Radiation Effect Research Foundation, Hiroshima and Nagasaki, in 2000-2002...
September 2016: Radiation Research
https://www.readbyqxmd.com/read/27538899/ganglionic-acetylcholine-receptor-autoantibodies-in-patients-with-autoimmune-diseases-including-primary-biliary-cirrhosis
#18
Yasuhiro Maeda, Shunya Nakane, Osamu Higuchi, Hideki Nakamura, Atsumasa Komori, Kiyoshi Migita, Akihiro Mukaino, Masataka Umeda, Kunihiro Ichinose, Mami Tamai, Shin-Ya Kawashiri, Waka Sakai, Hiroshi Yatsuhashi, Atsushi Kawakami, Hidenori Matsuo
OBJECTIVES: Autonomic dysfunction is closely associated with autoimmune diseases (AID) including primary biliary cirrhosis (PBC). The objective of this study was to determine the prevalence of anti-ganglionic (nicotinic) acetylcholine receptor (gAChR) antibodies in patients with AID. METHODS: We determined the presence of gAChR antibodies in serum samples from 146 patients (systemic lupus erythematosus [SLE] = 32; rheumatoid arthritis [RA] = 43; systemic sclerosis [SSc] = 38; PBC= 33) without information regarding autonomic symptoms, as well as 34 patients with other neurological diseases [OND], and 73 healthy controls [HC]...
September 30, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27507042/cytoskeletal-impairment-during-isoamyl-alcohol-induced-cell-elongation-in-budding-yeast
#19
Wakae Murata, Satoko Kinpara, Nozomi Kitahara, Yoshihiro Yamaguchi, Akira Ogita, Toshio Tanaka, Ken-Ichi Fujita
Isoamyl alcohol (IAA) induces pseudohyphae including cell elongation in the budding yeast Saccharomyces cerevisiae. Detailed regulation of microtubules and actin in developmental transition during cell elongation is poorly understood. Here, we show that although IAA did not affect the intracellular actin level, it reduced the levels of both α- and β-tubulins. In budding yeast, cytoplasmic microtubules are linked to actin via complexes consisting of at least Kar9, Bim1, and Myo2, and reach from the spindle pole body to the cortical attachment site at the bud tip...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27489866/lack-of-kir4-1-autoantibodies-in-japanese-patients-with-ms-and-nmo
#20
Osamu Higuchi, Shunya Nakane, Waka Sakai, Yasuhiro Maeda, Masaaki Niino, Toshiyuki Takahashi, Toshiyuki Fukazawa, Seiji Kikuchi, Kazuo Fujihara, Hidenori Matsuo
OBJECTIVES: To examine anti-KIR4.1 antibodies by 2 different assays in Japanese patients with multiple sclerosis (MS) or neuromyelitis optica (NMO). METHODS: One hundred sixty serum samples from 57 patients with MS, 40 patients with NMO/NMO spectrum disorder (NMOSD), and 50 healthy controls (all were Japanese) were tested with ELISA using a synthetic peptide of the first extracellular portion of human KIR4.1. In addition, we attempted to detect anti-KIR4.1 immunoglobulin G in the serum by the luciferase immunoprecipitation systems (LIPS) with the full length of human KIR4...
October 2016: Neurology® Neuroimmunology & Neuroinflammation
keyword
keyword
28972
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"