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https://www.readbyqxmd.com/read/29150978/mice-lacking-a-functional-nmda-receptor-exhibit-social-subordination-in-a-group-housed-environment
#1
Waka Ujita, Ayako Kohyama-Koganeya, Nozomi Endo, Toki Saito, Hiroshi Oyama
Social dominance, in which an individual asserts control over others or benefits most after social conflict, has an influence on social behaviour. However, the mechanisms mediating social dominance remain unclear. Social dominance within social groups determines the distribution of rewards such as food and access to mating partners, which can act as reinforcers. In this study, we used the water competition test to determine whether mice were dominant or subordinate. We have previously reported that mice heterozygous for a missense mutation in Grin1 (Grin1(Rgsc174) ) showed altered social behaviour, with increased locomotor activity, novelty-seeking and anxiety...
November 18, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29039050/the-protective-effect-of-fish-oil-lipid-emulsions-on-intestinal-failure-associated-liver-disease-in-a-rat-model-of-short-bowel-syndrome
#2
Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri
PURPOSE: Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis. METHODS: Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group)...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28993701/parkinson-s-disease-related-dj-1-functions-in-thiol-quality-control-against-aldehyde-attack-in-vitro
#3
Noriyuki Matsuda, Mayumi Kimura, Bruno Barros Queliconi, Waka Kojima, Masaki Mishima, Kenji Takagi, Fumika Koyano, Koji Yamano, Tsunehiro Mizushima, Yutaka Ito, Keiji Tanaka
DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD). Consequently, the full elucidation of DJ-1 function will help decipher the molecular mechanisms underlying PD pathogenesis. However, because various, and sometimes inconsistent, roles for DJ-1 have been reported, the molecular function of DJ-1 remains controversial. Recently, a number of papers have suggested that DJ-1 family proteins are involved in aldehyde detoxification. We found that DJ-1 indeed converts methylglyoxal (pyruvaldehyde)-adducted glutathione (GSH) to intact GSH and lactate...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28985724/association-between-dementia-and-discharge-status-in-patients-hospitalized-with-pneumonia
#4
Taisuke Jo, Hideo Yasunaga, Yusuke Sasabuchi, Nobuaki Michihata, Kojiro Morita, Yasuhiro Yamauchi, Wakae Hasegawa, Hideyuki Takeshima, Yukiyo Sakamoto, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase
BACKGROUND: Pneumonia is the most common cause of death in patients with dementia, but the outcomes of patients with dementia hospitalized with pneumonia are poorly understood. We sought to illuminate the association between dementia and in-hospital mortality and discharge status in patients hospitalized with pneumonia. METHODS: We used the Diagnosis Procedure Combination database, a national inpatient database in Japan, to identify retrospectively patients aged ≥60 years admitted to hospital with pneumonia during the study period of May 1, 2010 to March 31, 2014...
October 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28933704/the-association-between-serum-cytokine-and-chemokine-levels-and-antiviral-response-by-entecavir-treatment-in-chronic-hepatitis-b-patients
#5
Mio Kurihara, Masataka Tsuge, Eisuke Murakami, Nami Mori, Waka Ohishi, Takuro Uchida, Hatsue Fujino, Takashi Nakahara, Hiromi Abe-Chayama, Tomokazu Kawaoka, Daiki Miki, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Yizhou Zhang, Grace Naswa Makokha, C Nelson Hayes, Kazuaki Chayama
BACKGROUND: Although Nucleos(t)ide analogue therapy is thought to suppress chronic hepatitis B(CHB) via regulation of inflammatory cytokines/chemokines, the mechanism is still unclear. In this study, serum cytokine/chemokine levels were measured in CHB patients treated with entecavir, and the association with antiviral response was analyzed. METHODS: Seventy-eight Japanese patients with CHB were enrolled, and serum cytokine/chemokine levels were measured at baseline and at 12, 24, and 48 weeks of entecavir treatment using the MULTIPLEX kit...
September 21, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28924862/personal-inhalation-exposure-to-polycyclic-aromatic-hydrocarbons-and-their-nitro-derivatives-in-rural-residents-in-northern-thailand
#6
Walaiporn Orakij, Thaneeya Chetiyanukornkul, Thanyarat Chuesaard, Yuichi Kaganoi, Waka Uozaki, Chiharu Homma, Yaowatat Boongla, Ning Tang, Kazuichi Hayakawa, Akira Toriba
A personal inhalation exposure and cancer risk assessment of rural residents in Lampang, Thailand, was conducted for the first time. This highlighted important factors that may be associated with the highest areal incidence of lung cancer. Personal exposure of rural residents to polycyclic aromatic hydrocarbons (PAHs) and their nitro-derivatives (NPAHs) through inhalation of fine particulate matter (PM2.5) was investigated in addition to stationary air sampling in an urban area. The personal exposure of the subjects to PM2...
September 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28865952/sedative-and-physiological-effects-of-brimonidine-tartrate-ophthalmic-solution-in-healthy-cats
#7
Niwako Ogata, Teppei Kanda, Mizuki Kawahata, Takayasu Ichikawa, Yuki Matsumoto, Waka Morimitsu, Yukiko Nishino, Takamasa Itoi, Kayo Furumoto
OBJECTIVE: To determine the effects of brimonidine tartrate ophthalmic solution on sedation, heart rate (HR), respiratory frequency (fR), rectal temperature (RT) and noninvasive mean arterial pressure (MAP) in healthy cats. STUDY DESIGN: Randomized, blinded crossover study, with 1 week washout between treatments. ANIMALS: Six healthy purpose-bred cats. METHODS: Brimonidine tartrate ophthalmic solution 0.1% (one or two drops; 58...
July 3, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28865438/adjuvant-chemotherapy-versus-chemoradiotherapy-for-small-cell-lung-cancer-with-lymph-node-metastasis-a-retrospective-observational-study-with-use-of-a-national-database-in-japan
#8
Hirokazu Urushiyama, Taisuke Jo, Hideo Yasunaga, Yasuhiro Yamauchi, Hiroki Matsui, Wakae Hasegawa, Hideyuki Takeshima, Yoshihisa Hiraishi, Akihisa Mitani, Kiyohide Fushimi, Takahide Nagase
BACKGROUND: The optimal postoperative treatment strategy for small cell lung cancer (SCLC) remains unclear, especially in patients with lymph node metastasis. We aimed to compare the outcomes of patients with SCLC and lymph node metastasis treated with postoperative adjuvant chemotherapy or chemoradiotherapy. METHODS: We retrospectively collected data on patients with postoperative SCLC diagnosed with N1 and N2 lymph node metastasis from the Diagnosis Procedure Combination database in Japan, between July 2010 and March 2015...
September 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28862430/conformation-manipulation-and-motion-of-a-double-paddle-molecule-on-an-au-111-surface
#9
We-Hyo Soe, Yasuhiro Shirai, Corentin Durand, Yusuke Yonamine, Kosuke Minami, Xavier Bouju, Marek Kolmer, Katsuhiko Ariga, Christian Joachim, Waka Nakanishi
The molecular conformation of a bisbinaphthyldurene (BBD) molecule is manipulated using a low-temperature ultrahigh-vacuum scanning tunneling microscope (LT-UHV STM) on an Au(111) surface. BBD has two binaphthyl groups at both ends connected to a central durene leading to anti/syn/flat conformers. In solution, dynamic nuclear magnetic resonance indicated the fast interexchange between the anti and syn conformers as confirmed by density functional theory calculations. After deposition in a submonolayer on an Au(111) surface, only the syn conformers were observed forming small islands of self-assembled syn dimers...
October 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28836758/suppression-of-myogenic-differentiation-of-mammalian-cells-caused-by-fluidity-of-a-liquid-liquid-interface
#10
Kosuke Minami, Taizo Mori, Waka Nakanishi, Narumi Shigi, Jun Nakanishi, Jonathan P Hill, Makoto Komiyama, Katsuhiko Ariga
There is growing evidence to suggest that the prevailing physical microenvironment and mechanical stress regulate cellular functions, including adhesion, proliferation, and differentiation. Moreover, the physical microenvironment determines the stem-cell lineage depending on stiffness of the substrate relative to biological tissues as well as the stress relaxation properties of the viscoelastic substrates used for cell culture. However, there is little known regarding the biological effects of a fluid substrate, where viscoelastic stress is essentially absent...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28832498/corneal-fibroblasts-as-sentinel-cells-and-local-immune-modulators-in-infectious-keratitis
#11
REVIEW
Ken Fukuda, Waka Ishida, Atsuki Fukushima, Teruo Nishida
The cornea serves as a barrier to protect the eye against external insults including microbial pathogens and antigens. Bacterial infection of the cornea often results in corneal melting and scarring that can lead to severe visual impairment. Not only live bacteria but also their components such as lipopolysaccharide (LPS) of Gram-negative bacteria contribute to the development of inflammation and subsequent corneal damage in infectious keratitis. We describe the important role played by corneal stromal fibroblasts (activated keratocytes) as sentinel cells, immune modulators, and effector cells in infectious keratitis...
August 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804518/comparative-frequency-of-four-different-types-of-pregnancy-associated-thyrotoxicosis-in-a-single-thyroid-centre
#12
Akane Ide, Nobuyuki Amino, Takumi Kudo, Waka Yoshioka, Mako Hisakado, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura, Akira Miyauchi
BACKGROUND: Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves' disease during pregnancy (GD during pregnancy), postpartum destructive thyrotoxicosis (PPT), and postpartum Graves' thyrotoxicosis (PPGD) has not yet been determined. METHODS: We prospectively registered and performed a review of 4127 consecutive non treated female patients with thyrotoxicosis, seen between August 2008 and December 2013 in our outpatient clinic of Kuma Hospital...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28801834/current-characteristics-and-management-of-congenital-esophageal-stenosis-40-consecutive-cases-from-a-multicenter-study-in-the-kyushu-area-of-japan
#13
Masaya Suzuhigashi, Tatsuru Kaji, Hiroyuki Noguchi, Mitsuru Muto, Michiko Goto, Motoi Mukai, Kazuhiko Nakame, Takafumi Kawano, Waka Yamada, Koji Yamada, Shun Onishi, Satoshi Ieiri
PURPOSE: Congenital esophageal stenosis (CES) is rare, and the available clinical data are limited. We explored the current diagnosis, treatment and outcomes of CES. METHODS: A questionnaire survey was performed using medical records at pediatric surgical centers in the Kyushu area. RESULTS: Over 10 years, 40 patients (24 males) had CES. The incidence of associated anomalies was 52.5% (21/40), and that of esophageal atresia was 20.0% (8/40)...
October 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28801804/a-comparison-of-the-characteristics-and-precision-of-needle-driving-for-right-handed-pediatric-surgeons-between-right-and-left-driving-using-a-model-of-infant-laparoscopic-diaphragmatic-hernia-repair
#14
Takamasa Ikee, Shun Onishi, Motoi Mukai, Takafumi Kawano, Koshiro Sugita, Tomoe Moriguchi, Koji Yamada, Waka Yamada, Ryuta Masuya, Seiro Machigashira, Kazuhiko Nakame, Tatsuru Kaji, Satoshi Ieiri
PURPOSE: We compared the characteristics and precision of right and left needle driving for right-handed pediatric surgeons using a laparoscopic diaphragmatic repair model. METHODS: Eighteen right-handed pediatric surgeons performed three needle driving maneuvers using both hands. We evaluated the required time and conducted an image analysis. The total path length, velocity, and acceleration of the needle driving were also evaluated. RESULTS: Obtained results show the findings for the required time (s, Rt 310...
October 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28759061/molecular-rotors-confined-at-an-ordered-2d-interface
#15
Taizo Mori, Hirokazu Komatsu, Naoki Sakamoto, Kengo Suzuki, Jonathan P Hill, Mutsuyoshi Matsumoto, Hideki Sakai, Katsuhiko Ariga, Waka Nakanishi
Intramolecular rotation of molecules contained in a two-dimensional monolayer or a three-dimensional collapsed film at an air-water interface was investigated by in situ fluorescence spectroscopy of twisted intramolecular charge transfer (TICT) type 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ) derivatives. The TICT type molecules, CCVJ-C12 and CCVJ-Chol, that contain a linear alkyl dodecyl chain or a cholesteryl group, respectively, as their hydrophobic group, were designed and synthesized to manipulate them at the air-water interface...
July 31, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28730605/contributions-of-interleukin-33-and-tslp-in-a-papain-soaked-contact-lens-induced-mouse-conjunctival-inflammation-model
#16
Jobu Sugita, Yosuke Asada, Waka Ishida, Satoshi Iwamoto, Katsuko Sudo, Hajime Suto, Toru Matsunaga, Ken Fukuda, Atsuki Fukushima, Norihiko Yokoi, Tatsukuni Ohno, Miyuki Azuma, Nobuyuki Ebihara, Hirohisa Saito, Masato Kubo, Susumu Nakae, Akira Matsuda
INTRODUCTION: Pathological changes of severe chronic allergic conjunctivitis are driven not only via acquired immunity but also via innate immunity. Type 2 immune response-initiating cytokines may play some roles as innate immunity-dependent components of the ocular surface inflammation. To investigate the involvement of type 2 immune response-initiating cytokines in innate immunity-dependent, papain-induced conjunctival inflammation model using IL-25-, IL-33-, and TSLP receptor (TSLPR)-knockout (KO) mice with reference to basophils and ILC2...
July 20, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28725984/cytokine-expression-and-barrier-disruption-in-human-corneal-epithelial-cells-induced-by-alarmin-released-from-necrotic-cells
#17
Ken Fukuda, Waka Ishida, Yusaku Miura, Tatsuma Kishimoto, Atsuki Fukushima
PURPOSE: Dying cells release endogenous molecules known as alarmins that signal danger to surrounding tissue. We investigated the effects of necrotic cell-derived alarmins on cytokine expression and barrier function in human corneal epithelial cells. METHODS: The release of interleukin (IL)-6 and IL-8 from immortalized human corneal epithelial (HCE) cells in culture was measured with enzyme-linked immunosorbent assays. The abundance of IL-6 and 8 mRNAs was quantitated by reverse transcription and real-time polymerase chain reaction analysis...
July 19, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28694074/memory-b-cell-resurgence-requires-repeated-rituximab-in-myasthenia-gravis
#18
Kohei Muto, Naoko Matsui, Yuki Unai, Waka Sakai, Shotaro Haji, Kengo Udaka, Hirokazu Miki, Takahiro Furukawa, Masahiro Abe, Ryuji Kaji
The immunologic effects of rituximab (RTX) in myasthenia gravis (MG) remain to be explored. We aimed to clarify immunologic reactions and their association with response to RTX in MG. Regulatory T cell and B cell profiles of MG patients were monitored. Two patients presenting with generalized MG with anti-acetylcholine receptor antibodies were treated with RTX. The treatment led to sustained clinical improvement, discontinuation of intravenous immunoglobulin or plasma exchange, and reduction of prednisolone and other drugs...
June 21, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28681897/solid-surface-vs-liquid-surface-nanoarchitectonics-molecular-machines-and-dna-origami
#19
Katsuhiko Ariga, Taizo Mori, Waka Nakanishi, Jonathan P Hill
The investigation of molecules and materials at interfaces is critical for the accumulation of new scientific insights and technological advances in the chemical and physical sciences. Immobilization on solid surfaces permits the investigation of different properties of functional molecules or materials with high sensitivity and high spatial resolution. Liquid surfaces also present important media for physicochemical innovation and insight based on their great flexibility and dynamicity, rapid diffusion of molecular components for mixing and rearrangements, as well as drastic spatial variation in the prevailing dielectric environment...
September 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28676431/efficacy-of-oral-immunotherapy-with-a-rice-based-edible-vaccine-containing-hypoallergenic-japanese-cedar-pollen-allergens-for-treatment-of-established-allergic-conjunctivitis-in-mice
#20
Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima
BACKGROUND: We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice. METHODS: BALB/c mice were sensitized with two intraperitoneal injections of Japanese cedar pollen in alum, challenged with pollen in eyedrops, and then fed for 16 days with transgenic rice seeds expressing modified Japanese cedar pollen allergens Cry j 1 and Cry j 2 or with nontransgenic rice seeds as a control...
July 1, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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