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https://www.readbyqxmd.com/read/29777562/post-operative-stereotactic-radiotherapy-for-the-treatment-of-intracranial-haemangiopericytoma-a-study-of-dose-and-outcome
#1
Rohan Nair, Vanessa Panettieri, Joe H Chang, Michael Dally
INTRODUCTION: This study was performed to assess the relationship between tumour response and radiation dose in equivalent 2 Gy per fraction (EQD2). METHOD: A retrospective cohort analysis of 21 patients with a diagnosis of intracranial haemangiopericytoma between 2000 and 2013 was included in this study. A total of 39 lesions were analysed. The equivalent dose in 2 Gy per fraction was calculated by assigning an alpha-beta ratio of 12 Gy. A paired t-test compared dose (EQD2) and tumour response, and as the outcome was binary, a logistic regression analysis was performed...
May 19, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29772042/subfoveal-choroidal-thickness-as-a-potential-predictor-of-clinical-response-to-stereotactic-radiotherapy-for-neovascular-age-related-macular-degeneration
#2
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29765827/a-cross-sectional-survey-of-the-north-american-skull-base-society-current-practice-patterns-of-vestibular-schwannoma-evaluation-and-management-in-north-america
#3
Matthew L Carlson, Jamie J Van Gompel, R Mark Wiet, Nicole M Tombers, Anand K Devaiah, Devyani Lal, Jacques J Morcos, Michael J Link
Background  Very few studies have examined vestibular schwannoma (VS) management trends across centers and between providers. The objective of this study is to examine current practice trends, variance in treatment philosophies, and nuanced or controversial aspects of VS care across North America. Methods  This is a cross-sectional survey of North American Skull Base Society (NASBS) members who report regular involvement in VS care. Results  A total of 57 completed surveys were returned. Most respondents claimed to have over 20 years of experience and the majority reported working in an academic practice with an affiliated otolaryngology and/or neurosurgery residency program...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29765792/stereotactic-mri-guided-adaptive-radiation-therapy-smart-for-locally-advanced-pancreatic-cancer-a-promising-approach
#4
Elaine Luterstein, Minsong Cao, James Lamb, Ann C Raldow, Daniel A Low, Michael L Steinberg, Percy Lee
Locally advanced pancreatic cancer (LAPC) is characterized by poor prognosis and low response durability with standard-of-care chemotherapy or chemoradiotherapy treatment. Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy and allows for better integration with systemic therapy, may confer a survival benefit but is limited by gastrointestinal toxicity. Stereotactic MRI-guided adaptive radiation therapy (SMART) has recently gained attention for its potential to increase treatment precision and thus minimize this toxicity through continuous real-time soft-tissue imaging during radiotherapy...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29764593/-stereotactic-body-radiotherapy-for-centrally-located-non-small-cell-lung-cancer
#5
Yuming Wan, Jing Huang, Feng Xu
A few study has proven that about 90% of local control rates might be benefit from stereotactic body radiotherapy (SBRT) for patients with medically inoperable stage I non-small cell lung cancer (NSCLC), it is reported SBRT associated overall survival and tumor specific survival is comparable with those treated with surgery. SBRT has been accepted as the first line treatment for inoperable patients with peripheral located stage I NSCLC. However, the role of SBRT in centrally located lesions is controversial for potential toxic effects from the adjacent anatomical structure...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29764185/management-of-metastatic-spinal-cord-compression-among-veterans-health-administration-radiation-oncologists
#6
Ruchika Gutt, Sheeta Malhotra, Shruti Jolly, Drew Moghanaki, Alice V Cheuk, Helen Fosmire, Maria Kelly, Lori Hoffman-Hogg, Stephen Lutz, Mitchell Anscher, George Dawson
BACKGROUND: Optimal management of metastatic spinal cord compression (MSCC) improves functional outcomes in patients with metastatic disease. This survey study evaluated management of MSCC by Veterans Health Administration (VHA) radiation oncologists (ROs), to determine whether management of MSCC correlates with American College of Radiology (ACR) guidelines, and to compare times to initiation of treatment between surgery and radiotherapy (RT). METHODS: Surveys emailed to 79 VHA ROs included questions on steroid use, surgical care, palliative care, fractionation of irradiation, re-irradiation, and management of common MSCC case scenarios...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29763446/detector-specific-correction-factors-in-radiosurgery-beams-and-their-impact-on-dose-distribution-calculations
#7
Olivia A García-Garduño, Manuel A Rodríguez-Ávila, José M Lárraga-Gutiérrez
Silicon-diode-based detectors are commonly used for the dosimetry of small radiotherapy beams due to their relatively small volumes and high sensitivity to ionizing radiation. Nevertheless, silicon-diode-based detectors tend to over-respond in small fields because of their high density relative to water. For that reason, detector-specific beam correction factors ([Formula: see text]) have been recommended not only to correct the total scatter factors but also to correct the tissue maximum and off-axis ratios...
2018: PloS One
https://www.readbyqxmd.com/read/29759570/re-irradiation-as-salvage-treatment-in-recurrent-glioblastoma-a-comprehensive-literature-review-to-provide-practical-answers-to-frequently-asked-questions
#8
REVIEW
Silvia Scoccianti, Giulio Francolini, Giulio Alberto Carta, Daniela Greto, Beatrice Detti, Gabriele Simontacchi, Luca Visani, Muhammed Baki, Linda Poggesi, Pierluigi Bonomo, Monica Mangoni, Isacco Desideri, Stefania Pallotta, Lorenzo Livi
The primary aim of this review is to provide practical recommendations in terms of fractionation, dose, constraints and selection criteria to be used in the daily clinical routine. Based on the analysis of the literature reviewed, in order to keep the risk of severe side effects ≤3,5%, patients should be stratified according to the target volume. Thus, patients should be treated with different fractionation and total EQD2 (<12.5 ml: EQD2 < 65 Gy with radiosurgery; >12.5 ml and <35 ml: EQD2 < 50 Gy with hypofractionated stereotactic radiotherapy; >35 ml and <50 ml: EQD2 < 36 Gy with conventionally fractionated radiotherapy)...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#9
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29756264/study-design-and-early-result-of-a-phase-i-study-of-sabr-for-early-stage-glottic-cancer
#10
Tosol Yu, Chan Woo Wee, Noorie Choi, Hong-Gyun Wu, Hyun-Cheol Kang, Jong Min Park, Jung-In Kim, Jin Ho Kim, Tack-Kyun Kwon, Eun-Jae Chung
OBJECTIVE: Avoidance of organs at risk has become possible with advances in image-guided volumetric-modulated arc therapy (VMAT) techniques. This study was designed to evaluate the safety and feasibility of stereotactic ablative radiotherapy (SABR) for early stage glottic cancer. This report presents the preliminary result of the first and second dose level. METHODS: Fraction size was increased from 3.5 gray (Gy) (total dose 59.5 Gy) to 9 Gy (total dose 45 Gy). Dose-limiting toxicities were defined as grade 3 or higher treatment-related toxicities...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29755916/a-case-of-sinonasal-undifferentiated-carcinoma-with-brain-metastases
#11
Julianna Sienna, Nhu-Tram Nguyen, Julie Arsenault, Ian Hodson, Brandon Meyers
Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a unique case of an 80-year-old man who presented with a locally advanced SNUC involving the ethmoid, sphenoid, and maxillary sinuses and bilateral lymph nodes, clinical T4N2M0. Given his age and the initial extent of his primary tumour, he was treated with neoadjuvant chemotherapy followed by chemoradiation with a split course of 50 Gray (Gy) in 40 fractions delivered twice a day...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29754859/overall-survival-after-stereotactic-radiotherapy-or-surgical-metastasectomy-in-oligometastatic-renal-cell-carcinoma-patients-treated-at-two-swedish-centres-2005-2014
#12
M Stenman, G Sinclair, P Paavola, P Wersäll, U Harmenberg, M Lindskog
BACKGROUND AND PURPOSE: Investigate effects of stereotactic radiotherapy (SRT) or surgical metastasectomy (SM) on overall survival (OS) in metastatic renal cell carcinoma (mRCC) in the era of targeted agents (TA). MATERIAL AND METHODS: mRCC patients (n = 117) treated with SRT (n = 57), SM (n = 30) or both modalities sequentially (n = 30) at two oncological centres in Sweden in 2005-2014 were retrospectively included. Median follow-up (mFU) was 63 months...
May 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29754789/it-is-not-just-about-surgery-versus-stereotactic-ablative-radiotherapy-it-is-about-curing-as-many-patients-with-lung-cancer-as-possible
#13
EDITORIAL
Alessandro Brunelli
No abstract text is available yet for this article.
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29753550/rescue-procedure-for-an-electrical-storm-using-robotic-non-invasive-cardiac-radio-ablation
#14
Raphaël Jumeau, Mahmut Ozsahin, Juerg Schwitter, Véronique Vallet, Frédéric Duclos, Michele Zeverino, Raphaël Moeckli, Etienne Pruvot, Jean Bourhis
Stereotactic body radiotherapy (SBRT) is an emerging non-invasive treatment in the management of ventricular tachycardia (VT). We report here an intensive care patient suffering from an electrical storm due to incessant VT, unresponsive to catheter ablation and anti-arrhythmic drugs, showing an immediate and durable response to electrophysiology-guided cardiac SBRT.
May 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29752513/oligorecurrent-prostate-cancer-limited-to-lymph-nodes-getting-our-ducks-in-a-row-nodal-oligorecurrent-prostate-cancer
#15
Andrei Fodor, Andrea Lancia, Francesco Ceci, Maria Picchio, Morten Hoyer, Barbara Alicja Jereczek-Fossa, Piet Ost, Paolo Castellucci, Elena Incerti, Nadia Di Muzio, Gianluca Ingrosso
PURPOSE: Oligorecurrent prostate cancer with exclusive nodal involvement represents a common state of disease, amenable to local therapy. New radio-labeled tracers have enriched the possibility of cancer detection and treatment. In this review, we aim to illustrate the main nuclear medicine diagnostic options and the role of radiotherapy in this setting of patients. METHODS: We performed a PubMed search referring to the PRISMA guidelines to analyze the performance of PSMA- and choline-PET in detecting oligorecurrence limited to lymph nodes, and to review the main studies supporting either ablative stereotactic body radiotherapy or regional lymph node irradiation in this clinical setting...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29750133/use-of-indirect-target-gating-in-magnetic-resonance-guided-liver-stereotactic-body-radiotherapy-case-report-of-an-oligometastatic-patient
#16
Luca Boldrini, Francesco Cellini, Stefania Manfrida, Giuditta Chiloiro, Stefania Teodoli, Davide Cusumano, Bruno Fionda, Gian Carlo Mattiucci, Anna Maria De Gaetano, Luigi Azario, Vincenzo Valentini
The case of a 73-year-old woman affected by anal canal cancer with concomitant liver metastases is presented here. The patient was addressed to stereotactic body radiotherapy (SBRT) on two hepatic secondary lesions after the first radiochemotherapy treatment of the primary tumor. A Tri-60-Co magnetic resonance hybrid radiotherapy unit was used for SBRT treatment delivery. Both liver lesions were not clearly visible on the setup magnetic resonance imaging (MRI) due to their limited dimensions (maximum diameter 13 mm); however, the presence of two cysts adjacent to the metastases allowed the use of an indirect target gating approach...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29749129/plasma-cell-free-dna-as-a-predictive-marker-after-radiotherapy-for-hepatocellular-carcinoma
#17
Sangjoon Park, Eun Jung Lee, Chai Hong Rim, Jinsil Seong
PURPOSE: Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). MATERIALS AND METHODS: Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29747872/early-ultrasonographic-tumor-regression-after-linear-accelerator-stereotactic-fractionated-photon-radiotherapy-of-choroidal-melanoma-as-a-predictor-for-metastatic-spread
#18
Christoph Mitsch, Martin Zehetmayer, Andreas Gleiss, Dietmar Georg, Karin Dieckmann, Richard Pötter, Ramzi Sayegh, Ursula Schmidt-Erfurth, Roman Dunavoelgyi
BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent risk factor for metastasis...
May 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29746284/the-concept-of-oligometastases-in-colorectal-cancer-from-the-clinical-evidences-to-new-therapeutic-strategies
#19
Edouard Massaut, Ali Bohlok, Valerio Lucidi, Alain Hendlisz, Jean Klastersky, Vincent Donckier
PURPOSE OF REVIEW: The concept of oligometastases, defining cancers with limited metastatic capacity and attaining a limited number of secondary sites, is now widely accepted, particularly in colorectal cancer. Currently, however, accurate predictive markers for oligometastatic tumors are still lacking. For this reason, it remains challenging to translate this concept into clinical recommendations. In the present work, we review recent publications on oligometastases in colorectal cancer, showing the evidences for such presentation and underlying the need for the identification of biomarkers, necessary to further develop new therapeutic strategies...
May 4, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29745472/advanced-practice-radiation-therapists-an-australian-context
#20
REVIEW
Bronwyn Hilder, Pieter VanDam, Kathleen Doherty
The purpose of this scoping review is to examine the literature regarding the development, implementation, scope and extent of Advanced Practice Radiation Therapist (APRT) roles in Australia in peer reviewed journals, government reports, conference proceedings and reports. A search was undertaken of PubMed, Web of Science and CINAHL, the ASMIRT website and, and Google Scholar to identify relevant documents. Combinations of keywords with Boolean operators ((advanced practice) OR (advanced practitioner) OR (specialist)) AND ((radiation therapist) OR (radiation therapy)) were used...
May 10, 2018: Journal of Medical Radiation Sciences
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