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https://www.readbyqxmd.com/read/29342035/systematic-review-of-hearing-preservation-after-radiotherapy-for-vestibular-schwannoma
#1
Adam R Coughlin, Tyler J Willman, Samuel P Gubbels
OBJECTIVE: To determine the long-term hearing preservation rate for spontaneous vestibular schwannoma treated by primary radiotherapy. DATA SOURCES: The MEDLINE/PubMed, Web of Science, Cochrane Reviews, and EMBASE databases were searched using a comprehensive Boolean keyword search developed in conjunction with a scientific librarian. English language papers published from 2000 to 2016 were evaluated. STUDY SELECTION: Inclusion criteria: full articles, pretreatment and posttreatment audiograms or audiogram based scoring system, vestibular schwannoma only tumor type, reported time to follow-up, published after 1999, use of either Gamma Knife or linear accelerator radiotherapy...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29340771/predictive-factors-for-pharyngocutaneous-fistulization-after-total-laryngectomy-a-dutch-head-and-neck-society-audit
#2
Liset Lansaat, Vincent van der Noort, Simone E Bernard, Simone E J Eerenstein, Boudewijn E C Plaat, Ton A P M Langeveld, Martin Lacko, Frans J M Hilgers, Remco de Bree, Robert P Takes, Michiel W M van den Brekel
BACKGROUND: Incidences of pharyngocutaneous fistulization (PCF) after total laryngectomy (TL) reported in the literature vary widely, ranging from 2.6 to 65.5%. Comparison between different centers might identify risk factors, but also might enable improvements in quality of care. To enable this on a national level, an audit in the 8 principle Dutch Head and Neck Centers (DHNC) was initiated. METHODS: A retrospective chart review of all 324 patients undergoing laryngectomy in a 2-year (2012 and 2013) period was performed...
January 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29340031/analyzing-the-influence-of-kinase-inhibitors-on-dna-repair-by-differential-proteomics-of-chromatin-interacting-proteins-and-nuclear-phospho-proteins
#3
Lisa Gleißner, Marcel Kwiatkowski, Laura Myllynen, Pascal Steffen, Cordula Petersen, Kai Rothkamm, Hartmut Schlüter, Malte Kriegs
The combination of radiotherapy and pharmacological inhibition of cellular signal transduction pathways offers promising strategies for enhanced cancer cell inactivation. However, the molecular effects of kinase inhibitors especially on DNA damage detection and repair after X-irradiation have to be understood to facilitate the development of efficient and personalized treatment regimens. Therefore, we applied differential proteomics for analyzing inhibitor-induced changes in either chromatin-bound or phosphorylated nuclear proteins...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338444/adp53-gendicine-12-years-in-clinic-the-first-approved-gene-therapy-product-for-cancer
#4
Wei-Wei Zhang, Jianglong Li, Dinggang Li, Jiliang Liu, Xiuqin Li, Wei Li, Xiaolong Xu, Michael J Zhang, Lois Chandler, Hong Lin, Aiguo Hu, Wei Xu, Dominic Man-Kit Lam
Gendicine (Recombinant Human p53 Adenovirus, AdRSV-p53), developed by Shenzhen SiBiono GeneTech Company, was approved by CFDA in 2003. It has been used in clinical oncology for 12 years since it entered the market in 2004. As the first-in-class product for cancer gene therapy, Gendicine met its expectation and demonstrated with ample clinical data that it is safe and effective for treating cancer. SiBiono manufactured 41 batches in compliant with CFDA QC/QA requirements. Total 169,571 vials (1.0x1012 vector particles per vial) were used in more than 50,000 patients, among them about 5,000 were international form over 50 nations outside China...
January 16, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29332583/eating-green-shining-light-on-the-use-of-dietary-phytochemicals-as-a-modern-approach-in-the-prevention-and-treatment-of-head-and-neck-cancers
#5
Linda L Eastham, Candace M Howard, Premalatha Balachandran, David S Pasco, Pier Paolo Claudio
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29330865/a-case-of-radiation-induced-osteosarcoma-of-the-skull-presenting-as-a-cutaneous-epidermotropic-tumour-with-a-short-latent-period
#6
E Rashidghamat, E Calonje
Radiation induced sarcoma is an unusual but well documented tumor. The frequency of radiation induced sarcoma of the head and neck region has been reported as 0.143%. In the literature the median interval between irradiation and development of sarcoma is 11 years. Cases of RIS with a short latent period i.e. less than four years are rare. We report a case of a 34 year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, three years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of Temozolomide...
January 13, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29329660/cochlea-ct-radiomics-predicts-chemoradiotherapy-induced-sensorineural-hearing-loss-in-head-and-neck-cancer-patients-a-machine-learning-and-multi-variable-modelling-study
#7
Hamid Abdollahi, Shayan Mostafaei, Susan Cheraghi, Isaac Shiri, Seied Rabi Mahdavi, Anoshirvan Kazemnejad
OBJECTIVES: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. MATERIAL AND METHODS: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection operator (LASSO) penalized logistic regression were implemented on radiomic features for feature selection, classification and prediction...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29329114/synovial-sarcomas-of-the-upper-aero-digestive-tract-is-there-a-role-for-conservative-surgery
#8
Alberto Paderno, Alessandro Gronchi, Cesare Piazza
PURPOSE OF REVIEW: To present the current state of knowledge concerning the role of conservative surgery in the treatment of synovial sarcomas of the upper aero-digestive tract (UADT). RECENT FINDINGS: The wider experience on synovial sarcomas involving the extremities and the results of retrospective reports focused on head and neck synovial sarcomas tend to justify a conservative surgical approach when dealing with tumors involving the UADT. SUMMARY: UADT synovial sarcomas is an extremely rare clinical entity (only around 50 cases reported in the literature, with four more herein presented from our own surgical series), with no clear guidelines concerning its treatment...
January 11, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29326400/treatment-of-cutaneous-angiosarcoma-of-the-scalp-and-face-in-the-chinese-patients-local-experience-at-a-regional-hospital-in-hong-kong
#9
T L Chow, W Wy Kwan, C K Kwan
INTRODUCTION: Angiosarcoma is a rare aggressive sarcoma that occurs mostly in the skin of the head and neck in the elderly population. The optimal management is dubious and most studies are from Caucasian populations. We aimed to find out the treatment and outcome of this disease in Chinese patients. METHODS: Data of patients with histopathologically verified cutaneous angiosarcoma of the head and neck during December 1997 to September 2016 were retrieved from our cancer registry...
January 12, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29325396/treatment-results-of-radiotherapy-following-chop-or-r-chop-in-limited-stage-head-and-neck-diffuse-large-b-cell-lymphoma-a-single-institutional-experience
#10
Jae-Uk Jeong, Woong-Ki Chung, Taek-Keun Nam, Deok-Hwan Yang, Sung-Ja Ahn, Ju-Young Song, Mee Sun Yoon, Yong-Hyeob Kim
PURPOSE: This study evaluated outcomes of radiotherapy (RT) after chemotherapy in limited-stage head-and-neck diffuse large B-cell lymphoma (DLBCL). MATERIALS AND METHODS: Eighty patients who were treated for limited-stage head-and-neck DLBCL with CHOP (n = 43) or R-CHOP (n = 37), were analyzed. After chemotherapy, RT was administered to the extended field (n = 60) or the involved field (n = 16), or the involved site (n = 4). The median dose of RT ranged from 36 Gy in case of those with a complete response, to 45-60 Gy in those with a partial response...
December 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29325231/accuracy-of-fdg-pet-ct-response-assessment-following-radiotherapy-alone-for-head-and-neck-squamous-cell-carcinoma-retrospective-analysis-of-45-patients
#11
Jwala Philip, Ekin Ermiş, Finbar Slevin, Sriram Vaidyanathan, Mehmet Sen, Andrew F Scarsbrook, Robin J D Prestwich
FDG PET-CT is an established tool for response assessment following definitive concurrent chemoradiotherapy for head and neck squamous cell carcinoma with a high negative predictive value guiding treatment decisions. Little data is available regarding the accuracy of FDG PET-CT for response assessment following definitive radiotherapy without chemotherapy. We retrospectively analysed the accuracy of FDG PET-CT for response assessment following radiotherapy alone without planned neck dissection in 45 patients...
January 11, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29324861/cost-of-treatment-for-head-and-neck-cancer-in-india
#12
Akashdeep Singh Chauhan, Shankar Prinja, Sushmita Ghoshal, Roshan Verma, Arun S Oinam
There are no published data on the cost of cancer treatment for guiding reimbursement decisions in India. The present study was designed to estimate the cost of treating head and neck cancer (HNC) with the aim of determining package rates. The present study was undertaken in the Departments of Radiotherapy and Otolaryngology of a large tertiary care hospital in North India. Economic health system costs incurred were assessed using a bottom-up methodology. Data on all resources-capital or recurrent, incurred on the delivery of HNC treatment were collected from April 2014 to March 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29316962/hopon-hyperbaric-oxygen-for-the-prevention-of-osteoradionecrosis-a-randomised-controlled-trial-of-hyperbaric-oxygen-to-prevent-osteoradionecrosis-of-the-irradiated-mandible-study-protocol-for-a-randomised-controlled-trial
#13
Richard Shaw, Christopher Butterworth, Binyam Tesfaye, Matthew Bickerstaff, Susanna Dodd, Gary Smerdon, Seema Chauhan, Peter Brennan, Keith Webster, James McCaul, Peter Nixon, Anastasios Kanatas, Paul Silcocks
BACKGROUND: Osteoradionecrosis of the mandible is the most common serious complication of radiotherapy for head and neck malignancy. For decades, hyperbaric oxygen has been employed in efforts to prevent those cases of osteoradionecrosis that are precipitated by dental extractions or implant placement. The evidence for using hyperbaric oxygen remains poor and current clinical practice varies greatly. We describe a protocol for a clinical trial to assess the benefit of hyperbaric oxygen in the prevention of osteoradionecrosis during surgery on the irradiated mandible...
January 10, 2018: Trials
https://www.readbyqxmd.com/read/29314360/patient-reported-symptoms-and-stepwise-symptom-management-in-patients-on-epidermal-growth-factor-inhibitors-a-retrospective-descriptive-cohort-study
#14
J J Koldenhof, M H G Langenberg, P O Witteveen, S C C M Teunissen
Adverse events (AEs) of epidermal growth factor inhibitors (EGFRi) influence well-being with a risk to dose modifications (DMs). Hereby, clinical benefit of treatment might be affected. This retrospective cohort study was set up to gain insight into the suitability and added value of a patient-reported outcome measurement tool (PROM), together with a stepwise intervention management plan for EGFRi-related AEs in daily practice. The primary objective was to gain insight into total treatment duration and DMs, and the secondary objective to gain insight into patient-reported symptoms and well-being as well as healthcare professional-reported AEs...
January 4, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29313462/mucoepidermoid-carcinoma-a-23-year-experience-with-emphasis-on-low-grade-tumors-with-close-positive-margins
#15
Joseph Spellman, Gabriel Calzada
Objective Describe outcomes for mucoepidermoid carcinoma by histologic grade and evaluate outcomes for patients with low-grade tumors with close/positive margins after initial surgical resection. Study Design Cohort study. Setting Kaiser Permanente Southern California Medical Group from 1993 to 2016. Subjects and Methods Retrospective review of 154 patients with major and minor salivary gland mucoepidermoid carcinoma of the head and neck. Disease-specific and recurrence-free survival were stratified by tumor grade...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29313402/a-case-report-of-a-primary-apocrine-adenocarcinoma-of-the-eyelid-with-literature-review
#16
C Pagano Boza, R Vigo, J E Premoli, J Croxatto, J Gonzalez Barlatay
INTRODUCTION: Primary Apocrine adenocarcinomas (PAA) are very infrequent tumors that are often confused initially with benign lesions. Little is known about this disease and there is still much to be clarified. We present a case of PAA on the eyelid successfully treated with surgery alone and a literature review regarding what is currently described about this disease. METHODS: Noncomparative, retrospective case report of a patient with PAA on the eyelid succesfully treated with surgery alone and a literautre review...
January 9, 2018: Orbit
https://www.readbyqxmd.com/read/29313134/the-effectiveness-of-zataria-extract-mouthwash-for-the-management-of-radiation-induced-oral-mucositis-in-patients-a-randomized-placebo-controlled-double-blind-study
#17
Azar Aghamohammadi, Daryush Moslemi, Jafar Akbari, Arash Ghasemi, Mohammad Azadbakht, Askari Asgharpour, Seyed Jalal Hosseinimehr
OBJECTIVES: Oral mucositis (OM) is a common debilitating complication of chemoradiotherapy treatment of head and neck cancers. This randomized placebo-controlled double-blind clinical trial study was performed to evaluate the effectiveness of Zataria multiflora (ZM) extract mouthwash in the prevention and reduction of OM related to local radiotherapy in the treatment of head and neck cancer patients. METHODS: Sixty-three patients with head and neck cancers, who underwent a conventional fractionated radiotherapy regimen, were entered into the study...
January 8, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29311707/associations-of-tumor-pd-1-ligands-immunohistochemical-studies-and-textural-features-in-18f-fdg-pet-in-squamous-cell-carcinoma-of-the-head-and-neck
#18
Rui-Yun Chen, Ying-Chun Lin, Wei-Chih Shen, Te-Chun Hsieh, Kuo-Yang Yen, Shang-Wen Chen, Chia-Hung Kao
To know tumor PD-L1 expression through IHC or the FDG-PET related radiomics, we investigated the association between programmed cell death protein 1 ligand (PD-L1) expression and immunohistochemical (IHC) biomarkers or textural features of 18F-fluoro-2-deoxdeoxyglucose positron emission tomography (18F-FDG PET) in 53 oropharyngeal or hypopharyngeal cancer patients who were ready to undergo radiotherapy-based treatment. Differences in textural features or biomarkers between tumors with and without PD-L1 expression were tested using a Mann-Whitney U test...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29308525/-clinicopathological-features-of-carcinosarcoma-in-oromaxillofacial-head-and-neck-region
#19
Hai-Lei He, Zhong-Long Liu, Chun-Yue Ma, Xiao-Guang Li, Yue He
PURPOSE: To analyze the clinical features, histopathological features, treatment and prognosis of carcinosarcoma in oromaxillofacial head and neck region. METHODS: The clinical and histopathological data of 10 cases with carcinosarama were collected from database of Shanghai Ninth People's Hospital and further analyzed. RESULTS: A total of 10 cases (8 males and 2 females) of carcinosarcoma were collected and analyzed. The age of patients ranged from 20 to 81 years (mean: 44, median:45...
October 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29296112/preventive-effect-of-glycyrrhiza-glabra-extract-on-oral-mucositis-in-patients-under-head-and-neck-radiotherapy-a-randomized-clinical-trial
#20
Shamsolmolok Najafi, Soraiya Ebrahimpour Koujan, Soheila Manifar, Mohammad Javad Kharazifard, Saba Kidi, Samira Hajheidary
Objectives: About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients. This study aimed to assess the preventive effect of Glycyrrhiza aqueous extract on oral mucositis in cancer patients under head and neck radiotherapy. Materials and Methods: In this double-blind clinical trial, 37 head and neck cancer patients were divided into intervention (n=19) group receiving Glycyrrhiza aqueous extract and control (n=18) group receiving placebo...
September 2017: Journal of Dentistry of Tehran University of Medical Sciences
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