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head neck radiotherapy

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https://www.readbyqxmd.com/read/28730646/prospective-observational-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-carcinoma-of-the-head-and-neck
#1
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Takeo Takahashi, Tomoaki Tamaki, Hidemasa Kawamura, Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Junko Hirato, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Thirty-five patients were enrolled in this prospective study. The primary endpoint was the 3-year local control rate, while secondary endpoints included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and 3 patients received 64...
July 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28729131/eosinophilic-hyperplastic-lymphogranuloma-clinical-diagnosis-and-treatment-experience-of-41-cases
#2
Yang Jiang, Qingquan Hua, Jie Ren, Feng Zeng, Jianfei Sheng, Hua Liao, Zhijian Zhang, Hongxia Guan
PURPOSE: The purpose of this study was to investigate the clinical features of eosinophilic hyperplastic lymphogranuloma (EHLG) in the head and neck. MATERIALS AND METHODS: Collecting the patients who diagnose with EHLG by pathological examination. The EHLG patients with the masses involved regions, such as involved inguinal region, chest wall, abdominal wall, anterior superior iliac spine or clavicle, instead of head and neck were excluding. All of the participants will sign the informed consent form...
July 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28726971/an-environment-for-guideline-based-decision-support-systems-for%C3%A2-outpatients-monitoring
#3
Elisa M Zini, Giordano Lanzola, Paolo Bossi, Silvana Quaglini
OBJECTIVES: We propose an architecture for monitoring outpatients that relies on mobile technologies for acquiring data. The goal is to better control the onset of possible side effects between the scheduled visits at the clinic. METHODS: We analyze the architectural components required to ensure a high level of abstraction from data. Clinical practice guidelines were formalized with Alium, an authoring tool based on the PROforma language, using SNOMED-CT as a terminology standard...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28726687/a-new-sparse-optimization-scheme-for-simultaneous-beam-angle-and-fluence-map-optimization-in-radiotherapy-planning
#4
Hongcheng Liu, Peng Dong, Lei Xing
[Formula: see text]-minimization-based sparse optimization was employed to solve the beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) planning. The technique approximates the exact BAO formulation with efficiently computable convex surrogates, leading to plans that are inferior to those attainable with recently proposed gradient-based greedy schemes. In this paper, we alleviate/reduce the nontrivial inconsistencies between the [Formula: see text]-based formulations and the exact BAO model by proposing a new sparse optimization framework based on the most recent developments in group variable selection...
July 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28717702/management-of-chemoradiation-induced-mucositis-in-head-and-neck-cancers-with-oral-glutamine
#5
Lucy Pattanayak, Niharika Panda, Manoj Kumar Dash, Sumita Mohanty, Sagarika Samantaray
PURPOSE: Head and neck cancers are the third most common cancers worldwide. Oral mucositis is the most common toxicity seen in patients who receive chemoradiation to treat head and neck cancer. The aim of this study was to evaluate the efficacy and safety of oral glutamine supplementation in these patients. MATERIALS AND METHODS: From December 2013 to December 2014, we randomly assigned to two arms 162 patients who had squamous cell carcinoma of the head and neck...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714398/nutlin-3-a-p53-mdm2-antagonist-for-nasopharyngeal-carcinoma-treatment
#6
Voon Yee-Lin, Wong Pooi-Fong, Alan Khoo Soo-Beng
Nasopharyngeal carcinoma (NPC) is a form of head and neck cancer of multifactorial etiologies that is highly prevalent among men in the populations of Southern China and Southeast Asia. NPC has claimed many thousands of lives worldwide; but the low awareness of NPC remains a hindrance in early diagnosis and prevention of the disease. NPC is highly responsive to radiotherapy and chemotherapy, but radiocurable NPC is still dependent on concurrent treatment of megavoltage radiotherapy with chemotherapy. Despite a significant reduction in loco-regional and distant metastases, radiotherapy alone has failed to provide a significant improvement in the overall survival rate of NPC, compared to chemotherapy...
July 17, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28714364/influence-of-endoscopic-sinus-surgery-on-the-quality-of-life-of-patients-with-early-nasopharyngeal-carcinoma-and-the-analysis-of-prognosis-related-factors
#7
Yong-Feng Si, Gui-Ping Lan, Zhuo-Xia Deng, Jing-Jin Weng, Jin-Yuan Si, Yang-Da Qin, Bo Huang, Yong-Li Wang, Yong Yang, Yin Qin, Ben-Jian Zhang, Xing Han, Wei-Ming Xiong
The aim of this study is investigate the influence of endoscopic sinus surgery on the quality of life and prognosis of patients with early nasopharyngeal carcinoma. Patients initially diagnosed with early nasopharyngeal carcinoma and received surgical treatment were matched with nasopharyngeal carcinoma patients who received chemoradiotherapy at a ratio of 1:1, according to the following seven factors: gender, age, T staging, N staging, clinical staging, radiotherapy options, and chemotherapy options. Patients in the surgery group received endoscopic sinus surgery plus chemoradiotherapy, while subjects in the control group received chemoradiotherapy...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28713771/integrating-hyperthermia-into-modern-radiation-oncology-what-evidence-is-necessary
#8
REVIEW
Jan C Peeken, Peter Vaupel, Stephanie E Combs
Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28712323/management-of-cutaneous-merkel-cell-carcinoma
#9
William M Mendenhall, Christopher G Morris, Jessica M Kirwan, Robert J Amdur, Christiana Shaw, Peter T Dziegielewski
PURPOSE: To report the outcomes of patients with previously untreated cutaneous Merkel cell carcinoma (MCC) managed with curative intent. MATERIAL AND METHODS: Between December 1984 and August 2015, 59 patients with previously untreated cutaneous MCC were managed with curative intent with surgery and adjuvant radiotherapy (54 patients) or radiotherapy alone (5 patients) at the University of Florida. Primary sites included head and neck (45 patients), extremities (11 patients) and trunk (3 patients)...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28712070/flow-diverter-in-radiation-induced-skull-base-carotid-blowout-syndrome-do-not-write-it-off
#10
Gopinathan Anil, Junwei Zhang, Yew Kwang Ong, Francis Hui
Post-radiotherapy carotid blowout syndrome (CBS) of the skull base is a rare but often catastrophic complication of head and neck malignancies. The existing literature on the treatment of this condition with flow-diverting devices (FDD) is extremely limited and disappointing. We present a case of impending CBS in a patient previously irradiated for nasopharyngeal cancer that was successfully treated with use of multiple FDDs, adjunctive endonasal packing and delayed reinforcement with pedicled naso-septal flap, yielding an excellent outcome at 14-months follow-up...
July 16, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28711976/assessment-of-indomethacin-oral-spray-for-the-treatment-of-oropharyngeal-mucositis-induced-pain-during-anticancer-therapy
#11
Kenji Momo, Hiroka Nagaoka, Yoshiyuki Kizawa, Hiroki Bukawa, Shigeru Chiba, Yukinao Kohda, Masato Homma
PURPOSE: The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours. METHOD: We observed 35 patients (male/female, 20/15; 53 ± 17 years) with oropharyngeal mucositis who were treated with IM-OS preparation for pain relief at University of Tsukuba Hospital, Japan. Analgesic effects were assessed using the six-grade face scale for pain in 28 patients at the start of IM oral spray treatment...
July 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28709534/margin-analysis-sarcoma-of-the-head-and-neck
#12
REVIEW
Raafat F Makary, Arun Gopinath, Michael R Markiewicz, Rui Fernandes
Head and neck sarcomas are rare but are associated with significant morbidity/mortality and management difficulties. These tumors are best managed in a multidisciplinary setting. Open or core biopsy is essential for histologic diagnosis and grading. Complete surgical tumor resection with negative margins at the first attempt is the best chance for potential cure. In most patients, except those with small resectable low-grade lesions, adjuvant radiotherapy and chemotherapy are added to maximize local control with variable results...
August 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28708656/osteoradionecrosis-of-the-zygoma
#13
Zhuo-Jue Liu, Xue-Peng Xiong, Yi-Fang Zhao
Osteoradionecrosis occurs in 4.74% to 37.5% of patients following radiation therapy for head and neck cancer. Osteoradionecrosis mostly happens in the mandible but seldom occurs in other maxillofacial bones. Here, the authors reported a rare case of zygomatic osteoradionecrosis which occurred after maxillectomy and then radiotherapy because of maxillary myoepithelial carcinoma. After resection of zygoma sequestrum, the defect was repaired with forehead flap and healed uneventfully.
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28705952/hypoglossal-myokymia-presenting-as-paroxysmal-dysarthria-following-head-and-neck-radiotherapy
#14
Tiago Geraldes, Montserrat Alemany, Alicia Lozano, Roser Velasco
No abstract text is available yet for this article.
August 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28705099/heat-induced-brca2-degradation-in-human-tumors-provides-rationale-for-hyperthermia-parp-inhibitor-combination-therapies
#15
Nathalie van den Tempel, Hanny Odijk, Netteke van Holthe, Kishan Naipal, Anja Raams, Berina Eppink, Dik van Gent, Jose Hardillo, Gerda Verduijn, Jan Drooger, Gerard van Rhoon, Dineke Smedts, Helena van Doorn, Joost Boormans, Agnes Jager, Martine Franckena, Roland Kanaar
PURPOSE: Hyperthermia (40-44°C) effectively sensitizes tumors to radiotherapy by locally altering tumor biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRCA2-protein. This suggests that hyperthermia can expand the group of patients that benefit from PARP-inhibitors, a drug exploiting homologous recombination deficiency. Here, we explore whether the molecular mechanisms that cause heat-mediated degradation of BRCA2 are conserved in cell lines from various origins and, most importantly, whether, BRCA2 protein levels can be attenuated by heat in freshly biopted human tumors...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28702826/head-and-neck-diffuse-large-b-cell-lymphomas-hn-dlbcl-in-human-immunodeficiency-virus-hiv-positive-patients-long-term-results-in-the-highly-active-antiretroviral-therapy-haart-era
#16
Francesca De Felice, Andrea Di Mino, Lavinia Grapulin, Maria Lusia Mistrulli, Daniela Musio, Vincenzo Tombolini
To report long-term outcomes and toxicity rates after chemotherapy (CHT) followed by radiotherapy (RT) in the highly active antiretroviral therapy (HAART) era in human immunodeficiency virus (HIV) positive patients with head and neck diffuse large B cell lymphomas (HN-DLBCL). Clinical data concerning consecutive HIV patients treated for DLBCL located in head and neck region with CHT and RT were retrospectively reviewed. Systemic treatment consisted of combination CHT agents given with concomitant HAART and regimen was left to oncologists' discretion...
July 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28697190/-18-f-fdg-pet-ct-and-histology-for-diagnosing-recurrent-remnant-tumors-in-head-and-neck-cancer-patients-treated-with-radiotherapy
#17
Eun Ji Han, Joo Hyun O, Ie Ryung Yoo, Yeon Sil Kim, Min Sik Kim, Jin Hyoung Kang, Woo Hee Choi
OBJECTIVE: The aim of this study was to assess the diagnostic performance of fluorine-18-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) for locoregional recurrent/residual tumor in patients with head and neck cancer (HNC) who underwent previous radiotherapy (RT). SUBJECTS AND METHODS: (18)F-FDG PET/CT images from patients with HNC who previously underwent RT were retrospectively reviewed. Only cases with histological confirmation within 4 weeks of PET/CT imaging were included...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28694741/role-of-matrix-metalloproteinase-13-gene-expression-in-the-evaluation-of-radiation-response-in-oral-squamous-cell-carcinoma
#18
Shankar Sharan Singh, Madan Lal Brahma Bhatt, Vandana Singh Kushwaha, Anshuman Singh, Rajendra Kumar, Rajeev Gupta, Devendra Parmar
BACKGROUND: Matrix Metalloproteinase 13 (MMP13) is a member of collagenase family and it is involved in the degradation of extracellular matrix and basement membrane protein. It is thought to be associated with tumor invasion and metastasis. Elevated MMP13 expression has been found in carcinoma of the breast, urinary bladder, head and neck and others. It is observed that MMP13 gene is also correlated with radiation response in OSCC (Oral squamous cell carcinoma) cell line based study...
2017: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/28693449/multiparametric-magnetic-resonance-imaging-in-mucosal-primary-head-and-neck-cancer-a-prospective-imaging-biomarker-study
#19
Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler, Gary Liney
BACKGROUND: Radical radiotherapy, with or without concomitant chemotherapy forms the mainstay of organ preservation approaches in mucosal primary head and neck cancer. Despite technical advances in cancer imaging and radiotherapy administration, a significant proportion of patients fail to achieve a complete response to treatment. For those patients who do achieve a complete response, acute and late toxicities remain a cause of morbidity. A critical need therefore exists for imaging biomarkers which are capable of informing patient selection for both treatment intensification and de-escalation strategies...
July 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28692743/a-flexible-multivariate-random-effects-proportional-odds-model-with-application-to-adverse-effects-during-radiation-therapy
#20
Nicole H Augustin, Sung Won Kim, Annemarie Uhlig, Christina Hanser, Michael Henke, Martin Schumacher
Radiation therapy in patients with head and neck cancer has a toxic effect on mucosa, the soft tissue in and around the mouth. Hence mucositis is a serious common side effect and is a condition characterized by pain and inflammation of the surface of the mucosa. Although the mucosa recovers during breaks of and following the radiotherapy course, the recovery will depend on the type of tissue involved and on its location. We present a novel flexible multivariate random effects proportional odds model that takes account of the longitudinal course of oral mucositis at different mouth sites and of the radiation dosage (in terms of cumulative dose)...
July 10, 2017: Biometrical Journal. Biometrische Zeitschrift
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