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head neck radiotherapy

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https://www.readbyqxmd.com/read/28802390/pediatric-head-and-neck-bone-sarcomas-an-analysis-of-204-cases
#1
Jacob S Brady, Sei Y Chung, Emily Marchiano, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull. METHODS: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. RESULTS: In total, 204 patients were included in the analysis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801178/impact-of-head-and-neck-radiotherapy-on-the-mechanical-behavior-of-composite-resins-and-adhesive-systems-a-systematic-review
#2
REVIEW
Cristhian Camilo Madrid Troconis, Alan Roger Santos-Silva, Thaís Bianca Brandão, Marcio Ajudarte Lopes, Mario Fernando de Goes
OBJECTIVES: To analyze the evidence regarding the impact of head and neck radiotherapy (HNRT) on the mechanical behavior of composite resins and adhesive systems. METHODS: Searches were conducted on PubMed, Embase, Scopus and ISI Web of Science databases using "Radiotherapy", "Composite resins" and "Adhesive systems" as keywords. Selected studies were written in English and assessed the mechanical behavior of composite resins and/or adhesive systems when bonding procedure was conducted before and/or after a maximum radiation dose ≥50Gy, applied under in vitro or in vivo conditions...
August 8, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28799829/radiotherapy-induces-cell-cycle-arrest-and-cell-apoptosis-in-nasopharyngeal-carcinoma-via-the-atm-and-smad-pathways
#3
Ming-Yi Li, Jin-Quan Liu, Dong-Ping Chen, Zhou-Yu Li, Bin Qi, Lu He, Yi Yu, Wen-Jin Yin, Meng-Yao Wang, Ling Lin
Nasopharyngeal carcinoma (NPC) is a common malignant neoplasm of the head and neck which is harmful to human's health. Radiotherapy is commonly used in the treatment of NPC and it induces immediate cell cycle arrest and cell apoptosis. However, the mechanism remains unknown. Evidences suggested the activation of Ataxia telangiectasia mutated (ATM) pathway and Smad pathway are two of the important crucial mediators in the function of radiotherapy. In this study, we carried out in vitro assays with human nasopharyngeal carcinoma CNE-2 cells and in vivo assays with nude mice to investigate the role of the ATM and Smad pathways in the treatment of nasopharyngeal carcinoma with radiotherapy...
August 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28799273/sensitivity-of-array-detector-measurements-in-determining-shifts-of-mlc-leaf-positions
#4
Qingyang Shang, Andrew Godley, Long Huang, Peng Qi, Ping Xia
Using a MatriXX 2D ionization chamber array, we evaluated the detection sensitivity of systematically introduced MLC leaf positioning shifts to test whether the conventional IMRT QA method can be used for quality assurance of an MLC tracking algorithm. Because of finite special resolution, we first tested whether the detection sensitivity was dependent of the locations of leaf shifts and positions of ionization chambers. We then introduced the same systematic leaf shifts in two clinical intensity modulated radiotherapy plans (prostate and head and neck cancer)...
August 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28797456/rebamipide-gargle-in-preventive-management-of-chemo-radiotherapy-induced-oral-mucositis
#5
B Chaitanya, Keerthilatha M Pai, Prahlad H Yathiraj, Donald Fernandes, Yogesh Chhaparwal
BACKGROUND & OBJECTIVES: Oral mucositis is inflammation of mucosa of oral cavity which is an inevitable and acute side effect in patients undergoing chemoradiotherapy for head & neck cancer. Though many agents have been tried in prevention & treatment of oral mucositis, until date no single agent exists that is universally established to be effective. METHODS: 60 Patients diagnosed with Head & Neck cancer recruited for concurrent chemo-radiotherapy were assigned in a double blind fashion into 2 groups using computer based 1:1 ratio randomization...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797452/outcome-following-radiotherapy-for-head-and-neck-basal-cell-carcinoma-with-aggressive-features
#6
Anupam Rishi, Shao Hui Huang, Brian O'Sullivan, David P Goldstein, Lin Lu, Jolie Ringash, John Waldron, Woody Wells, Alex Sun, Andrew Hope, Peter Chung, Meredith Giuliani, Anna Spreafico, Li Tong, Wei Xu, Andrew Bayley
OBJECTIVES: The literature demonstrates that 'aggressive' head-and-neck basal cell carcinomas (HN-BCC) have a higher than expected relapse rate with unfavorable outcomes. We report outcomes following definitive (dRT) or post-operative radiotherapy (PORT) for these tumors. METHODS: We reviewed all HN-BCC patients with 'aggressive' features (primary lesions diameter >10mm, >2 recurrences, or extra-cutaneous extension), treated with megavoltage dRT or PORT between 1998 and 2013...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28794691/biological-role-of-long-non-coding-rna-in-head-and-neck-cancers
#7
REVIEW
Tomasz Kolenda, Kacper Guglas, Marcel Ryś, Marta Bogaczyńska, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna M Lamperska
Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules - long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28794640/volumetric-modulated-arc-therapy-for-treatment-of-solid-tumors-current-insights
#8
REVIEW
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28790865/survivorship-of-patients-with-head-and-neck-cancer-receiving-care-in-a-tertiary-health-facility-in-nigeria
#9
Vitalis C Okwor, Adeniyi F Fagbamigbe, Olufunmilayo I Fawole
BACKGROUND: Head and neck cancer (HNC) is a major clinical and public health concern worldwide which impairs the vital functions of life. The treatment of metastatic HNCs is mainly palliative. This study examined the survival patterns and treatment outcomes in patients with HNCs in a tertiary hospital in Nigeria. MATERIALS AND METHODS: A review of the case files and treatment cards of patients with histological diagnosis of HNCs seen between January 2002 and December 2011 at the Radiotherapy Department, University College Hospital, Ibadan, was conducted...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28781810/effect-of-intratumoral-abscess-necrosis-on-the-outcome-for-head-and-neck-cancer-patients-treated-by-hypofractionated-stereotactic-re-irradiation-using-cyberknife%C3%A2
#10
Hideya Yamazaki, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Tadayuki Kotsuma, Ken Yoshida, Yasuo Yoshioka
The aim of the present study was to elucidate the effect of intratumoral abscess/necrosis (AN) on the outcome of patients with recurrent head and neck cancer (HNC) treated by stereotactic radiotherapy. The records of 67 patients treated with CyberKnife® in four institutes between August 2000 and July 2010 were reviewed. The frequency of AN appeared to be increased in younger postoperative patients with large ulcerative tumors. The AN(+) group exhibited a better initial response rate compared with the AN(-) group (64 vs...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28771941/dosimetric-and-radiobiological-comparison-for-quality-assurance-of-imrt-and-vmat-plans
#11
Nava Raj Paudel, Ganesh Narayanasamy, Eun Young Han, Jose Penagaricano, Panayiotis Mavroidis, Xin Zhang, Anil Pyakuryal, Dongwook Kim, Xiaoying Liang, Steven Morrill
INTRODUCTION: The gamma analysis used for quality assurance of a complex radiotherapy plan examines the dosimetric equivalence between planned and measured dose distributions within some tolerance. This study explores whether the dosimetric difference is correlated with any radiobiological difference between delivered and planned dose. METHODS: VMAT or IMRT plans optimized for 14 cancer patients were calculated and delivered to a QA device. Measured dose was compared against planned dose using 2-D gamma analysis...
August 3, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28771540/18f-fdg-pet-ct-for-the-detection-of-disease-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy
#12
Nils Helsen, Dessie Roothans, Bert Van Den Heuvel, Tim Van den Wyngaert, Danielle Van den Weyngaert, Laurens Carp, Sigrid Stroobants
OBJECTIVE: The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings. METHODS: Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied retrospectively. RESULTS: 104 FDG-PET/CT-scans were performed at a median of 13...
2017: PloS One
https://www.readbyqxmd.com/read/28770294/automated-imrt-planning-in-pinnacle-a%C3%A2-study-in-head-and-neck-cancer
#13
J M A M Kusters, K Bzdusek, P Kumar, P G M van Kollenburg, M C Kunze-Busch, M Wendling, T Dijkema, J H A M Kaanders
PURPOSE: This study evaluates the performance and planning efficacy of the Auto-Planning (AP) module in the clinical version of Pinnacle 9.10 (Philips Radiation Oncology Systems, Fitchburg, WI, USA). METHODS AND MATERIALS: Twenty automated intensity-modulated radiotherapy (IMRT) plans were compared with the original manually planned clinical IMRT plans from patients with oropharyngeal cancer. RESULTS: Auto-Planning with IMRT offers similar coverage of the planning target volume as the original manually planned clinical plans, as well as better sparing of the contralateral parotid gland, contralateral submandibular gland, larynx, mandible, and brainstem...
August 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28766791/symptom-burden-and-patient-characteristics-association-with-quality-of-life-in-patients-with-head-and-neck-cancer-undergoing-radiotherapy
#14
Guro Lindviksmoen Astrup, Tone Rustøen, Kristin Hofsø, Jon Michael Gran, Kristin Bjordal
BACKGROUND: Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics...
August 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28765061/unilateral-tongue-myokymia-a-rare-topodiagnostic-sign-of-different-clinical-conditions
#15
Daniela Leupold, Lenka Schilg, Ansgar Felbecker, Olaf Chan-Hi Kim, Barbara Tettenborn, Thomas Hundsberger
Myokymia of the tongue is a very rare clinical condition and is much less common than facial or focal myokymia of the limbs. Radiation-induced delayed nerve damage is a well-known cause of myokymia, but other etiologies i.e. tumor recurrence should be considered as a differential diagnosis. We describe a case series of neurophysiologically proven unilateral tongue myokymia, which arose in two patients after radiotherapy of the neck/head and in one patient due to a space occupying meningioma of the cerebrospinal passage affecting the hypoglossal nerve...
July 29, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28764811/survival-impact-of-pre-treatment-neutrophils-on-oropharyngeal-and-laryngeal-cancer-patients-undergoing-definitive-radiotherapy
#16
Whitney A Sumner, William A Stokes, Ayman Oweida, Kiersten L Berggren, Jessica D McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D Karam
BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC)...
August 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28763137/cognitive-function-and-patient-reported-memory-problems-after-radiotherapy-for-cancers-at-the-skull-base-a-cross-sectional-survivorship-study-using-the-telephone-interview-for-cognitive-status-and-the-md-anderson-symptom-inventory-head-and-neck-module
#17
Chase C Hansen, Joshua B Smith, Abdallah S R Mohamed, Collin F Mulcahy, Jeffrey S Wefel, Katherine A Hutcheson, Kelsey Chrane, Jack Phan, Steven J Frank, Adam S Garden, Blaine D Smith, Hillary Eichelberger, Carthal Anderson, Colton McCoy, Marina Horiates, Conner Patrick, Sarah Floris, Chloe French, Beth M Beadle, William H Morrison, Shirley Y Su, Carol M Lewis, Michael E Kupferman, Jason M Johnson, Heath D Skinner, Stephen Y Lai, Ehab Y Hanna, David I Rosenthal, Clifton D Fuller, G Brandon Gunn
BACKGROUND: Using patient-reported and objective assessment tools, we sought to quantify cognitive symptoms and objective cognitive dysfunction in patients irradiated for skull base cancer. METHODS: Participants were assessed using the Telephone Interview for Cognitive Status (TICS) and the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN), with subsequent analysis. RESULTS: Of the 122 participants analyzed, the majority (63%) had no frank detectable cognitive impairment by TICS, with frank impairment in 6%...
August 1, 2017: Head & Neck
https://www.readbyqxmd.com/read/28762462/radiation-induced-neurocognitive-dysfunction-in-head-and-neck-cancer-patients
#18
Francesca De Felice, Pierre Blanchard
It might seem odd that a special issue about Gianni Bonadonna would publish a review on radiation-induced neurocognitive dysfunction. Dr. Gianni Bonadonna is considered a pioneer in medical oncology history, mainly due to new and revolutionary treatment approaches proposed in breast cancer and Hodgkin lymphoma. He had an active role in the field of medical oncology, especially through lectures and textbooks. He shared his considerable insight of understanding cancer behavior and evaluating research advances over the years to prevent tumor recurrence and preserve patients from unnecessary toxicity...
July 31, 2017: Tumori
https://www.readbyqxmd.com/read/28762317/effects-of-plasma-activated-medium-on-head-and-neck-fadu-cancerous-cells-comparison-of-3d-and-2d-response
#19
Merbahi Nofel, Julie Chauvin, Patricia Vicendo, Florian Judée
OBJECTIVE: The aim of this work is to investigate the inhibitory effect of Plasma Activated Medium (PAM) on Head and Neck cancerous cells (FaDu).. The response of FaDu cells in monolayer cultures and Multi Cellular Tumor Spheroids (MCTS) after treatment with different PAMs will be compared. BACKGROUND: Head and Neck squamous cell carcinoma is a widespread cancer that responds poorly to anti-cancer treatments such as chemotherapy and radiotherapy. Recently growth interest in cold plasmas and their application in cancer therapy...
August 1, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28762137/a-clinicopathologic-study-of-head-and-neck-malignant-peripheral-nerve-sheath-tumors
#20
Adepitan A Owosho, Cherry L Estilo, Joseph M Huryn, Ping Chi, Cristina R Antonescu
Head and neck high grade malignant peripheral nerve sheath tumors (HN-MPNSTs) are rare highly aggressive soft tissue sarcomas that show overlapping morphologic and immunophenotypic features with melanoma and other high grade sarcomas, resulting in diagnostic challenges, particularly in sporadic settings. Recent discoveries have implicated loss of function mutations in the polycomb repressive complex 2 (PRC2) components, including EED or SUZ12 genes, as one of the leading pathogenetic mechanisms in high grade MPNST...
July 31, 2017: Head and Neck Pathology
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