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https://www.readbyqxmd.com/read/28340451/the-role-of-drug-drug-interactions-in-prostate-cancer-treatment-focus-on-abiraterone-acetate-prednisone-and-enzalutamide
#1
REVIEW
Marzia Del Re, Stefano Fogli, Lisa Derosa, Francesco Massari, Paul De Souza, Stefania Crucitta, Sergio Bracarda, Daniele Santini, Romano Danesi
Elderly patients with cancer may have comorbidities, each requiring additional pharmacologic treatment. Therefore, the occurrence of pharmacokinetic (PK) and pharmacodynamic (PD) interactions is very likely, and the risk of adverse reactions (ADRs), due to the narrow therapeutic window of anticancer drugs, is increased. Drug-drug interactions (DDIs) may occur in prostate cancer patients due to inhibition by abiraterone of liver cytochrome P450 (CYP)-dependent enzymes CYP2C8 and 2D6, which are involved in the metabolism of approximately 25% of all drugs, and induction by enzalutamide of CYP3A4, 2C9 and 2C19, which metabolize up to 50% of medications...
March 9, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28340230/determinants-of-opioid-prescribing-for-nonmalignant-chronic-pain-in-us-outpatient-settings
#2
Rafia S Rasu, Maureen E Knell
Study Objectives.:  Identify prescribing trends for opioid use in non-malignant chronic pain (NMCP) from the National Ambulatory Medical Care Survey (NAMCS). Determine predictors of opioid use based on patient-specific factors. Design.:  This cross-sectional study analyzed NAMCS data from 2000 to 2007. Pain medications prescribed were retrieved using NAMCS drug codes. Multivariate logistic models examined determinants of opioid prescribing among NMCP patients...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339747/deep-learning-for-pharmacovigilance-recurrent-neural-network-architectures-for-labeling-adverse-drug-reactions-in-twitter-posts
#3
Anne Cocos, Alexander G Fiks, Aaron J Masino
Objective: Social media is an important pharmacovigilance data source for adverse drug reaction (ADR) identification. Human review of social media data is infeasible due to data quantity, thus natural language processing techniques are necessary. Social media includes informal vocabulary and irregular grammar, which challenge natural language processing methods. Our objective is to develop a scalable, deep-learning approach that exceeds state-of-the-art ADR detection performance in social media...
February 22, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339523/factors-affecting-the-quality-of-life-of-chronic-dialysis-patients
#4
Beata Jankowska-Polanska, Izabella Uchmanowicz, Agata Wysocka, Bartosz Uchmanowicz, Katarzyna Lomper, Andrzej M Fal
: Patients on hemodialysis must adjust their life plans to the treatment. They are aware of losing their health and independence. Therefore, acceptance of illness (AI) is important and allows the patient to adjust to new situation and alleviates negative emotions The aim of study was to assess the impact of AI and other socioclinical variables on hemodialysis patients' quality of life (QoL).The study included 100 patients aged 20-85 (M = 57), treated with hemodialysis for at least 2 years. Two validated instruments were used: the Acceptance of Illness Scale (AIS) and the World Health Organization Quality of Life questionnaire...
October 19, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28339433/management-of-neuropathic-chronic-pain-with-methadone-combined-with-ketamine-a-randomized-double-blind-active-controlled-clinical-trial
#5
Flavia Karine Rigo, Gabriela Trevisan, Maria C Godoy, Mateus Fortes Rossato, Gerusa D Dalmolin, Mariane A Silva, Mirian S Menezes, Wolnei Caumo, Juliano Ferreira
BACKGROUND: Methadone and ketamine are used in neuropathic pain management. However, the benefits of both drugs association are uncertain in the treatment of neuropathic pain. OBJECTIVE: Our primary objective was test the hypothesis that oral methadone combined with oral ketamine is more effective than oral methadone or ketamine alone in reducing neuropathic pain. STUDY DESIGN: We conducted a randomized, double blind, active-controlled parallel-group clinical trial...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339327/raising-public-awareness-of-clinical-trials-development-of-messages-for-a-national-health-communication-campaign
#6
Holly A Massett, David M Dilts, Robert Bailey, Jennifer Berktold, Rebecca Ledsky, Nancy L Atkinson, Grace Mishkin, Andrea Denicoff, Rose Mary Padberg, Marin P Allen, Karen Silver, Kelli Carrington, Lenora E Johnson
Clinical trials are essential for developing new and effective treatments and improving patient quality of life; however, many trials cannot answer their primary research questions because they fall short of their recruitment goals. This article reports the results of formative research conducted in two populations, the public and primary care physicians, to identify messages that may raise awareness and increase interest in clinical trials and be used in a national communication campaign. Results suggested that participants were primarily motivated to participate in clinical trials out of a self-interest to help themselves first...
March 24, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28338742/brain-mechanisms-for-loss-of-awareness-of-thought-and-movement
#7
Eamonn Walsh, David A Oakley, Peter W Halligan, Mitul A Mehta, Quinton Deeley
Loss or reduction of awareness is common in neuropsychiatric disorders and culturally influenced dissociative phenomena but the underlying brain mechanisms are poorly understood. fMRI was combined with suggestions for automatic writing in 18 healthy highly hypnotically suggestible individuals in a within-subjects design to determine whether clinical alterations in awareness of thought and movement can be experimentally modelled and studied independently of illness. Subjective ratings of control, ownership, and awareness of thought and movement, and fMRI data were collected following suggestions for thought insertion and alien control of writing movement, with and without loss of awareness...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28338614/unintentional-injuries-and-violence-among-adults-in-northern-jordan-a-hospital-based-retrospective-study
#8
Manal M Alzghoul, Mohammed K Shakhatreh, Nihaya Al-Sheyab
Injuries (unintentional and intentional) are the main cause of death and disability worldwide, including Jordan. The main purpose of this hospital-based retrospective study was to identify characteristics, causes, and risk factors of unintentional injuries and violence among all adult patients who approached the Accidents and Emergency department because of injury in Northern Jordan. Data were collected retrospectively from four major hospitals from January 2008 to January 2013. A total of 2425 Jordanian individuals who accessed and were treated by the four hospitals were included in this study...
March 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28338590/small-changes-big-effects-the-hemodynamics-of-partial-and-complete-aortic-occlusion-to-inform-next-generation-resuscitation-techniques-and-technologies
#9
M Austin Johnson, Anders J Davidson, Rachel M Russo, Sarah-Ashley E Ferencz, Oren Gotlib, Todd E Rasmussen, Lucas P Neff, Timothy K Williams
BACKGROUND: The transition from complete aortic occlusion during Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) can be associated with hemodynamic instability. Technique refinements and new technologies have been proposed to minimize this effect. In order to inform new techniques and technology, we examined the relationship between blood pressure and aortic flow during the restoration of systemic circulation following aortic occlusion at progressive levels of hemorrhage...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28338495/burden-of-hearing-loss-on-communication-partners-and-its-influence-on-pursuit-of-hearing-evaluation
#10
Kristine A Schulz, Naomi Modeste, Jerry W Lee, Rhonda Roberts, Gabrielle H Saunders, David L Witsell
OBJECTIVE: Describe how the burden on the communication partner (CP) from the patient's hearing loss, as perceived by both the patient and their CP, influences a patient's pursuit of hearing evaluation. DESIGN: Cross-sectional design. Demographics, perception of patient's hearing loss, and associated burden on the CP were collected from both patient and CP via online questionnaires. Patients and their CPs from Duke University Medical Center Otolaryngology Clinic, 55 to 75 years of age, being seen for any reason, who indicated a CP has expressed concern about their hearing...
March 23, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28337925/the-impact-of-a-highly-publicized-celebrity-suicide-on-suicide-related-online-information-seeking
#11
Florian Arendt, Sebastian Scherr
BACKGROUND: Research has already acknowledged the importance of the Internet in suicide prevention as search engines such as Google are increasingly used in seeking both helpful and harmful suicide-related information. AIMS: We aimed to assess the impact of a highly publicized suicide by a Hollywood actor on suicide-related online information seeking. METHOD: We tested the impact of the highly publicized suicide of Robin Williams on volumes of suicide-related search queries...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28337852/turning-potential-into-action-using-pluripotent-stem-cells-to-understand-heart-development-and-function-in-health-and-disease
#12
Hananeh Fonoudi, Alexis Bosman
Pluripotent stem cells hold enormous potential for regenerative therapies, however their ability to provide insight into early human development and the origins of disease could arguably provide an even greater outcome. This is primarily due to their contribution to the establishment of a powerful knowledge base of human development, something which all researchers and clinicians can potentially benefit from. Modeling human heart development and disease using pluripotent stem cells has already provided many important insights into cardiogenesis and cardiovascular disease mechanisms however, it is important to be aware of the complexities of this model system...
March 24, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28337684/capsule-commentary-on-pham-kanter-et-al-public-awareness-of-and-contact-with-physicians-who-receive-industry-payments-a-national-survey
#13
Susannah L Rose
No abstract text is available yet for this article.
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28337632/comparative-toxicity-of-imidacloprid-and-thiacloprid-to-different-species-of-soil-invertebrates
#14
Cláudia de Lima E Silva, Nicola Brennan, Jitske M Brouwer, Daniël Commandeur, Rudo A Verweij, Cornelis A M van Gestel
Neonicotinoid insecticides have come under increasing scrutiny for their impact on non-target organisms, especially pollinators. The current scientific literature is mainly focused on the impact of these insecticides on pollinators and some aquatic insects, leaving a knowledge gap concerning soil invertebrates. This study aimed at filling this gap, by determining the toxicity of imidacloprid and thiacloprid to five species of soil invertebrates: earthworms (Eisenia andrei), enchytraeids (Enchytraeus crypticus), Collembola (Folsomia candida), oribatid mites (Oppia nitens) and isopods (Porcellio scaber)...
March 23, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28337584/-i-can-t-take-hold-of-some-kind-of-a-life-the-role-of-social-connectedness-and-confidence-in-engaging-lost-adolescents-with-their-lives
#15
Nicole M Ja, Paul E Jose
Erik Erikson's theoretical writings on identity have provided a rich foundation upon which decades of research on identity development have been built. However, literature is lacking regarding adolescents who are aware that they lack knowledge about the self (i.e., values, likes, and dislikes) to the extent that they are stuck and directionless, and therefore unable to engage in the process of identity formation, what we refer to as a state of "lostness." Furthermore, while it has been established that supportive relationships facilitate identity development, less is known about whether various domains of social connectedness may diminish "lostness" over time, and if so, what may be the specific processes or conditions within each connectedness domain that supports this aspect of identity development...
March 23, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28337530/chronic-sialadenitis-due-to-the-stone-inside-the-accessory-duct-of-submandibular-gland
#16
Murat Binar, Mert Cemal Gokgoz, Umit Aydin, Ibrahim Yavan, Serdar Karahatay
PURPOSE: Sialolithiasis is the most common cause of chronic sialadenitis. In this case report, intraoperative finding of an accessory submandibular duct, obstructed with stone, originating from the same gland nearby the main Warthon's duct, is presented. CASE REPORT: A 22-year-old male patient, suffering from eating-related pain and swelling in his left submandibular region, was diagnosed with left sublandibular gland sialadenitis with radiologically manifested sialolithiasis, and gland excision was advised...
March 23, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28337433/occupational-stress-and-burnout-among-surgeons-in-fiji
#17
Rajeev Patel, Peter Huggard, Annik van Toledo
AIM: This study examined the levels of occupational stress and burnout among surgeons in Fiji. METHODS: A document set comprising a cover letter; a consent form; a sociodemographic and supplementary information questionnaire; the Maslach Burnout Inventory (MBI); the 12-item General Health Questionnaire (GHQ-12); the Alcohol Use Disorders Identification Test (AUDIT); and the Professional Quality of Life (ProQOL) questionnaires were provided to surgeons from three public divisional hospitals in Fiji...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28337406/the-influence-of-health-concern-on-travel-plans-with-focus-on-the-zika-virus-in-2016
#18
Nicole J Olynk Widmar, S R Dominick, Audrey Ruple, Wallace E Tyner
Tourists consider many factors, including health, when choosing travel destinations. The potential for exposure to novel or foreign diseases alone can deter travelers from selecting high-risk locations for disease transmission. The 2015-2016 Zika Virus (ZIKV) outbreak in the Americas and Caribbean prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern. This study investigated factors that may contribute to travel avoidance to areas experiencing ZIKV transmission while also considering different levels of health concern and awareness among groups with varying demographics...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28337195/nk-cells-uncertain-allies-against-malaria
#19
REVIEW
Asia-Sophia Wolf, Samuel Sherratt, Eleanor M Riley
Until recently, studies of natural killer (NK) cells in infection have focused almost entirely on their role in viral infections. However, there is an increasing awareness of the potential for NK cells to contribute to the control of a wider range of pathogens, including intracellular parasites such as Plasmodium spp. Given the high prevalence of parasitic diseases in the developing world and the devastating effects these pathogens have on large numbers of vulnerable people, investigating interactions between NK cells and parasitized host cells presents the opportunity to reveal novel immunological mechanisms with the potential to aid efforts to eradicate these diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28337089/evaluation-of-the-environmental-noise-levels-in-abuja-municipality-using-mobile-phones
#20
T Ibekwe, D Folorunso, A Ebuta, J Amodu, M Nwegbu, Z Mairami, I Liman, C Okebaram, C Chimdi, B Durogbola, H Suleiman, H Mamven, N Baamlong, E Dahilo, I Gbujie, P Ibekwe, O Nwaorgu
BACKGROUND: Noise remains a nuisance which impacts negatively on the physical, social and psychological wellbeing of man. It aggravates chronic illnesses like hypertension and other cardiopulmonary diseases. Unfortunately, increased activities from industrialization and technological transfers/drifts have tumultuously led to increased noise pollution in most of our fast growing cities today and hence the need for concerted efforts in monitoring and regulating our environmental noise. OBJECTIVE: To assess the equivalent noise level (Leq) in Abuja municipality and promote a simple method for regular assessment of Leq within our environment...
December 2016: Annals of Ibadan Postgraduate Medicine
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