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https://www.readbyqxmd.com/read/28260569/peter-elmer-witchcraft-witch-hunting-and-politics-in-early-modern-england-oxford-oxford-university-press-2016-pp-%C3%A2-384-%C3%A2-65-00-hardback-isbn-%C3%A2-978-0-19-19-871772-0
#1
https://www.readbyqxmd.com/read/28238198/the-social-historical-and-institutional-contingencies-of-dam-removal
#2
F J Magilligan, C S Sneddon, C A Fox
Environmental managers in the United States and elsewhere are increasingly perceiving dam removal as a critical tool for river restoration and enhancing watershed resilience. In New England, over 125 dams have been dismantled for ecological and economic rationales. A surprising number of these removals, including many that are ongoing, have generated heated conflicts between restoration proponents and local communities who value their dammed landscapes. Using a comparative case study approach, we examine the environmental conflict around efforts to remove six dams in New England...
February 25, 2017: Environmental Management
https://www.readbyqxmd.com/read/28235801/the-scaffolding-protein-nherf1-regulates-the-stability-and-activity-of-the-tyrosine-kinase-her2
#3
Jaekwang Jeong, Joshua N Vanhouten, Wonnam Kim, Pamela Dann, Catherine Sullivan, Jungmin Choi, W Bruce Sneddon, Peter A Friedman, John J Wysolmerski
Unlike other ErbB family members, ErbB2/HER2/Neu (HER2) is not internalized but remains on the cell surface when activated. This allows for prolonged signaling and contributes to its transforming ability. Previous studies have shown that the calcium pump, PMCA2, interacts with HER2 within membrane protrusions and is required for the retention of HER2 on the cell surface. In this study, we knocked down NHERF1 expression in breast cancer cells lines and examined whether the scaffolding protein, NHERF1, interacts with PMCA2 and HER2...
February 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28166193/a-loop-of-cancer-stroma-cancer-interaction-promotes-peritoneal-metastasis-of-ovarian-cancer-via-tnf%C3%AE-tgf%C3%AE-egfr
#4
T-S Lau, L K-Y Chan, E C-H Wong, C W-C Hui, K Sneddon, T-H Cheung, S-F Yim, J H-S Lee, C S-Y Yeung, T K-H Chung, J Kwong
Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts enhance colony formation of metastatic ovarian cancer cells, and de novo expression of transforming growth factor-alpha (TGF-α) is induced in stromal fibroblasts co-cultured with ovarian cancer cells. We also observed an over-expression of tumor necrosis factor-alpha (TNF-α) in ovarian cancer cells, which is regulated by promoter DNA hypomethylation as well as chromatin remodeling...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28112424/exercise-and-the-multidisciplinary-holistic-approach-to-adolescent-dysautonomia
#5
K R Armstrong, A M De Souza, P L Sneddon, J E Potts, V E Claydon, S Sanatani
AIM: To determine whether an eight-week strength training programme as part of a multidisciplinary approach would minimise symptoms and improve quality of life in patients with dysautonomia. METHODS: Adolescents referred to a tertiary-level cardiology service from May 2014-December 2015 with symptoms of dysautonomia were eligible. Participants completed an exercise test and a quality of life (QoL) questionnaire (PedsQL) prior to the intervention. Participants were asked to complete exercises five times per week...
January 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108048/bullous-pseudobullous-pustular-dermatoses
#6
Mark R Wick
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Examples of such disorders include impetigo, Herpes virus infections, pemphigus, bullous pemphigoid and pemphigoid gestationis, epidermolysis bullosa acquisita, IgA-related dermatoses, inherited epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27874892/idiopathic-livedo-racemosa-presenting-with-splenomegaly-and-diffuse-lymphadenopathy
#7
Laura Bukavina, Joshua Weaver, Teri Nagy, Robert T Brodell, Eliot N Mostow
Sneddon syndrome (SS) is a rare condition and the diagnosis is made only when other more common disease entities have been excluded. Common manifestations in SS patients include hypertension, coronary artery disease, venous thrombosis, miscarriages, psychiatric disturbances, and arterial and venous thrombotic events. Most patients present in their early 30s with classic neurovascular and dermatologic signs. Currently, the main criteria for the diagnosis of SS include livedo racemosa, focal neurological deficits or evidence of stroke on magnetic resonance imaging, or characteristic vascular alterations seen on biopsy...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27832122/inducing-cold-sensitivity-in-the-frigophilic-fly-drosophila-montana-by-rnai
#8
Felipe M Vigoder, Darren J Parker, Nicola Cook, Océane Tournière, Tanya Sneddon, Michael G Ritchie
Cold acclimation is a critical physiological adaptation for coping with seasonal cold. By increasing their cold tolerance individuals can remain active for longer at the onset of winter and can recover more quickly from a cold shock. In insects, despite many physiological studies, little is known about the genetic basis of cold acclimation. Recently, transcriptomic analyses in Drosophila virilis and D. montana revealed candidate genes for cold acclimation by identifying genes upregulated during exposure to cold...
2016: PloS One
https://www.readbyqxmd.com/read/27759698/occlusive-nonvasculitic-vasculopathy-a-review
#9
Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27742664/a-bioimage-informatics-platform-for-high-throughput-embryo-phenotyping
#10
James M Brown, Neil R Horner, Thomas N Lawson, Tanja Fiegel, Simon Greenaway, Hugh Morgan, Natalie Ring, Luis Santos, Duncan Sneddon, Lydia Teboul, Jennifer Vibert, Gagarine Yaikhom, Henrik Westerberg, Ann-Marie Mallon
High-throughput phenotyping is a cornerstone of numerous functional genomics projects. In recent years, imaging screens have become increasingly important in understanding gene-phenotype relationships in studies of cells, tissues and whole organisms. Three-dimensional (3D) imaging has risen to prominence in the field of developmental biology for its ability to capture whole embryo morphology and gene expression, as exemplified by the International Mouse Phenotyping Consortium (IMPC). Large volumes of image data are being acquired by multiple institutions around the world that encompass a range of modalities, proprietary software and metadata...
October 14, 2016: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/27721909/phase-composition-and-disorder-in-la2-sn-ti-2o7-ceramics-new-insights-from-nmr-crystallography
#11
Arantxa Fernandes, David McKay, Scott Sneddon, Daniel M Dawson, Sebastian Lawson, Richard Veazey, Karl R Whittle, Sharon E Ashbrook
An NMR crystallographic approach, involving the combination of (119)Sn NMR spectroscopy, XRD, and DFT calculations, is demonstrated for the characterization of La2Sn2-x Ti x O7 ceramics. A phase change from pyrochlore (La2Sn2O7) to a layered perovskite phase (La2Ti2O7) is predicted (by radius ratio rules) to occur when x ≈ 0.95. However, the sensitivity of NMR spectroscopy to the local environment is able to reveal a significant two-phase region is present, extending from x = 1.8 to ∼0.2, with limited solid solution at the two extremes, in broad agreement with powder XRD measurements...
September 15, 2016: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/27702417/differences-in-expenditure-and-amounts-of-fresh-foods-fruits-and-vegetables-and-fish-purchased-in-urban-and-rural-scotland
#12
Baukje de Roos, Ferdinando Binacchi, Stephen Whybrow, Alan A Sneddon
OBJECTIVE: To quantitatively analyse expenditure on all fresh foods, fruits and vegetables (F&V) and fish across urban and rural households in Scotland. Fresh foods were chosen since, in general, they are perceived to contribute more to health than processed foods. DESIGN: Descriptive analysis of purchase data of all foods brought into the home during 2012 from the Kantar Worldpanel database. Purchase data were restricted to fresh, unprocessed and raw foods or 'fresh to frozen' foods where freezing was part of harvesting...
October 5, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27621276/dentigerous-cyst-and-ameloblastoma-of-the-jaws-correlating-the-histopathological-and-clinicoradiological-features-avoids-a-diagnostic-pitfall
#13
Andrew W Barrett, Kenneth J Sneddon, John V Tighe, Aakshay Gulati, Laurence Newman, Jeremy Collyer, Paul M Norris, Darryl M Coombes, Michael J Shelley, Brian S Bisase, Rachael D Liebmann
Aim To determine how many ameloblastomas were misdiagnosed as dentigerous cysts (DCs) by correlating the radiological and histopathological features of a series of both entities. Methods and results Histopathology reports and radiological imaging of 135 DCs and 43 ameloblastomas were reviewed. Any clinical or radiological feature that suggested that the diagnosis of DC was wrong-for example, absence of an unerupted tooth-prompted review of the original histology. A total of 34 cases coded as DC at diagnosis were excluded; in the remaining 101 patients, the clinicoradiological and histopathological features were consistent with DC in 96 (95...
September 12, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27599640/rationale-and-recommendations-for-improving-definitions-registration-requirements-and-procedures-related-to-fetal-death-and-stillbirth
#14
K S Joseph, M Basso, C Davies, L Lee, D Ellwood, D B Fell, D Fowler, B Kinniburgh, M S Kramer, K Lim, P Selke, D Shaw, A Sneddon, A Sprague, K Williams
No abstract text is available yet for this article.
September 7, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27552338/using-facebook-as-a-platform-for-self-regulated-curriculum-evaluation-and-feedback-for-medical-students
#15
J G Boyle, J M Cullen, S Sneddon, N Sartania, M Shepherd
No abstract text is available yet for this article.
September 2016: Medical Teacher
https://www.readbyqxmd.com/read/27537782/report-of-a-meeting-on-contemporary-topics-in-zebrafish-husbandry-and-care
#16
Nikki Osborne, Gregory Paull, Adam Grierson, Karen Dunford, Elisabeth M Busch-Nentwich, Lynne U Sneddon, Natalie Wren, Joe Higgins, Penny Hawkins
A meeting on Contemporary Topics in Zebrafish Husbandry and Care was held in the United Kingdom in 2014, with the aim of providing a discussion forum for researchers, animal technologists, and veterinarians from academia and industry to share good practice and exchange ideas. Presentation topics included protocols for optimal larval rearing, implementing the 3Rs (replacement, reduction, and refinement) in large-scale colony management, and environmental enrichment. The audience also participated in a survey of current practice relating to practical husbandry, cryopreservation, and the provision of enrichment...
December 2016: Zebrafish
https://www.readbyqxmd.com/read/27516004/complete-remission-of-skin-lesions-in-a-patient-with-subcorneal-pustular-dermatosis-sneddon-wilkinson-disease-treated-with-antimyeloma-therapy-association-with-disappearance-of-m-protein
#17
P A von dem Borne, M F Jonkman, R van Doorn
Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also been observed in patients with IgA myeloma. In SPD, direct and indirect immunofluorescence studies do not reveal in vivo bound IgA to the epithelial cell surface, in contrast to IgA pemphigus, which has similar clinicopathological features...
August 12, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27490977/branch-retinal-artery-occlusion-associated-with-paracentral-acute-middle-maculopathy-in-a-patient-with-livedo-reticularis
#18
Paul Baciu, Candice M Nofar, Justin Spaulding, Hua Gao
PURPOSE: To report the occurrence of a branch retinal artery occlusion with paracentral acute middle maculopathy in an otherwise healthy young man with a history of livedo reticularis (LR). METHODS: Retrospective case report. PATIENTS: A 21-year-old man with a history of LR being treated with pentoxifylline developed an acute branch retinal artery occlusion with initial best-corrected visual acuity at presentation of 20/80. RESULTS: A thorough diagnostic work up was negative for potential causes of branch retinal artery occlusion or LR...
August 2, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27432882/convergent-signaling-pathways-regulate-parathyroid-hormone-and-fibroblast-growth-factor-23-action-on-npt2a-mediated-phosphate-transport
#19
W Bruce Sneddon, Giovanni W Ruiz, Luciana I Gallo, Kunhong Xiao, Qiangmin Zhang, Youssef Rbaibi, Ora A Weisz, Gerard L Apodaca, Peter A Friedman
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 on phosphate transport and the role of the PDZ protein NHERF1 in mediating PTH and FGF23 effects. RPTECs express the NPT2A phosphate transporter, αKlotho, FGFR1, FGFR3, FGFR4, and the PTH receptor. FGFR1 isoforms are formed from alternate splicing of exon 3 and of exon 8 or 9 in Ir-like loop 3...
September 2, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27375446/analysis-of-individual-mouse-activity-in-group-housed-animals-of-different-inbred-strains-using-a-novel-automated-home-cage-analysis-system
#20
Rasneer S Bains, Heather L Cater, Rowland R Sillito, Agisilaos Chartsias, Duncan Sneddon, Danilo Concas, Piia Keskivali-Bond, Timothy C Lukins, Sara Wells, Abraham Acevedo Arozena, Patrick M Nolan, J Douglas Armstrong
Central nervous system disorders such as autism as well as the range of neurodegenerative diseases such as Huntington's disease are commonly investigated using genetically altered mouse models. The current system for characterizing these mice usually involves removing the animals from their home-cage environment and placing them into novel environments where they undergo a battery of tests measuring a range of behavioral and physical phenotypes. These tests are often only conducted for short periods of times in social isolation...
2016: Frontiers in Behavioral Neuroscience
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