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H Bakhtiar, H Mirzaei, M R Bagheri, N Fani, F Mashhadiabbas, M Baghaban Eslaminejad, D Sharifi, M H Nekoofar, Pmh Dummer
OBJECTIVES: The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs. MATERIAL AND METHODS: DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group...
October 20, 2016: Clinical Oral Investigations
Sindhu M Ganvir, Pratima G Khobragade, Swati A Bamane, Ramnivas Kumavat, Amit Dalmia
BACKGROUND: The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth and to examine its role in progression and invasion of tumors. METHOD: Thirty paraffin embedded specimens AM (15 were non-aggressive ameloblastomas and 15 ameloblastoma showing aggressive behavior), 15 paraffin embedded specimens of AOT, 15 paraffin embedded specimens of CEOT, 15 paraffin embedded specimens of CCOT were obtained and were analyzed by immunohistochemistry using anti-human podoplanin...
September 2016: Journal of Oral Biology and Craniofacial Research
K Zemplenyi, B Lopez, M Sardesai, J K Dillon
The progression of odontogenic infections to necrotizing soft tissue infections (NSTIs) is unknown. The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score is used to predict risk of NSTI. This study aimed to (1) estimate the frequency at which odontogenic infections progress to NSTIs, (2) measure the value of LRINEC in predicting progression to NSTI, and (3) estimate the charges associated with managing NSTIs. This retrospective cohort study enrolled all subjects admitted for the management of odontogenic infections from 2001 to 2013...
October 15, 2016: International Journal of Oral and Maxillofacial Surgery
Zana Agani, Vjosa Hamiti-Krasniqi, Jehona Recica, Mergime Prekazi Loxha, Fisnik Kurshumliu, Aida Rexhepi
BACKGROUND: Ameloblastoma is a benign epithelial odontogenic tumor. It is often aggressive and destructive, with the capacity to attain great size, erode bone and invade adjacent structures. Unicystic ameloblastoma is a rare odontogenic lesion, with clinical, radiographic and gross features of jaw cysts. The lesion histologically shows typical ameloblastomatous epithelium lining part of the cyst cavity with or without and/or mural tumor growth. Unicystic ameloblastoma usually presents in posterior mandibular ramus region, while it is rare and atypical in posterior maxillary region...
October 18, 2016: BMC Research Notes
Soung Min Kim, Emmanuel K Amponsah, Hui Young Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee
: Ameloblastoma is the most common benign odontogenic tumor of the jaw, and expansional growth of a huge untreated ameloblastoma can result in disturbances in facial aesthetics and function, such as difficulty with mouth opening, swallowing, chewing, breathing, neurologic deficits, and pathologic fractures. Radical wide resection with safety margins and subsequent reconstruction is generally recommended. A fibular free flap (FFF) is commonly used to reconstruct the mandible in order to adequately restore both aesthetic appearance and function...
September 2016: Ghana Medical Journal
Ying Yuan, Jingbo Wang, Yingwei Wu, Guojun Li, Xiaofeng Tao
Based on the histopathologic origin, malignant maxillary neoplasms may share some clinical characteristics but have different biological behavior, treatments, and prognoses. The aim of the present study was to explore the association between CT characteristics and tissue origin of primary maxillary cancer (MC). A retrospective review of CT findings was performed in patients diagnosed with MC between January 1, 2005 and December 31, 2013. Univariate and multivariable logistic regression analyses were performed to determine the association between tissue of origin and CT characteristics, with adjustment for possible confounding factors...
October 2016: Medicine (Baltimore)
Leorik Pereira da Silva, Marianna Sampaio Serpa, Thalita Santana, George João Ferreira do Nascimento, Emanuel Sávio de Souza Andrade, Ana Paula Veras Sobral
Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs...
October 17, 2016: European Archives of Oto-rhino-laryngology
Tuula M Eriksson, Richard M Day, Stefano Fedele, Vehid M Salih
Ameloblastoma is a rare, odontogenic neoplasm with benign histopathology, but extensive, local infiltrative capacity through the bone tissue it originates in. While the mechanisms of ameloblastoma invasion through the bone and bone absorption are largely unknown, recent investigations have indicated a role of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand regulatory mechanisms. Here, we present results obtained using a novel in vitro organotypic tumour model, which we have developed using tissue engineering techniques...
January 2016: Journal of Tissue Engineering
J A Baart, J F L Bosgra
A dentist is expected to be able to recognise and treat pain originating from the teeth. When dealing with short-term, acute pain, the cause can sometimes be found quickly, while this can be much harder in the case of chronic pain. Especially in this latter category, one should be even more careful in diagnostics and choose reversible treatments when possible. A focused anamnesis, a pain journal and trial local anaesthesia can help to identify the suspected cause of the pain. Careful extra- and intraoral examination is needed to reach a proper diagnosis...
October 2016: Nederlands Tijdschrift Voor Tandheelkunde
Andrew Wood, Fiona Young, James Morrison, Brendon I Conn
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100...
July 25, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Stephanie Tan, Dimitrios Nikolarakos
Although less frequently encountered in dental practices, subcutaneous emphysema of the face and neck has been reported in patients following dental extractions, particularly when lower molar teeth are extracted with the use of a high speed air turbine drill designed for restorative treatment, which forces air into the cervical fascial spaces. As facial swelling and pain are the most common presentations, subcutaneous emphysema can often be misdiagnosed as an allergic reaction or odontogenic infection. While usually a benign and self limiting condition, subcutaneous emphysema may have life threatening complications such as tension pneumothorax, cardiac tamponade, air embolism, tracheal compression and mediastinitis, which are important to recognise in an emergency setting...
October 14, 2016: Australian Dental Journal
Safoura Seifi, Shabnam Sohanian, Oveis Khakbaz, Farida Abesi, Fatemeh Aliakbarpour, Arezoo Rayani
INTRODUCTION: The ectopic ciliated cyst is a rare non-odontogenic cyst which occurs as a delayed complication after maxillary sinus radical surgery; this lesion emerges due to the destruction of the sinus mucosa during the surgery and entrapment of the respiratory epithelium in the region. This lesion has been observed in very rare cases following genioplasty and bimaxillary orthognathic surgery. CASE REPORT: We reported a case of the ectopic ciliated cyst in in the mandible of a 37-year-old Iranian woman following genioplasty and Lefort 1 surgery after 2 years...
September 2016: Iranian Journal of Otorhinolaryngology
Sivakumar Nuvvula, Swapna Manepalli, Abinash Mohapatra, Sreekanth Kumar Mallineni
Cementoblastoma is a benign lesion of the odontogenic ectomesenchymal origin. It rarely occurs in primary dentition. This report describes a case of a cementoblastoma relating to the right mandibular second primary molar in a 7-year-old girl. Her panoramic radiograph revealed a well-defined radiopaque lesion with a radiolucent border extending from the distal surface of the mandibular right first primary molar to the distal surface of mandibular second primary molar. The tumor was attached to the mesial root of primary second molar and was excised along with the teeth involved and sent for histopathological evaluation, which showed irregular trabeculae of mineralized tissue interspersed with fibrovascular connective tissue, trabeculae of mineralized tissue with prominent reversal lines, and peripheral rimming of the mineralized tissue with blast cells...
2016: Case Reports in Dentistry
Fernanda Paula Yamamoto Silva, Andrielle Dias, Carolinne Almeida Coelho, Eliete Neves Guerra, Ana Elizia Mascarenhas Marques, Daniel de Almeida Decurcio, Andrea Mantesso, Sérgio Elias Vieira Cury, Brunno Santos de Freitas Silva
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively...
October 10, 2016: Brazilian Oral Research
G L Fadda, M Berrone, E Crosetti, G Succo
The widespread use of dental implants and reconstructive procedures for their positioning has led to an increase in sinonasal complications of dental disease and treatment (SCDDT). Diagnosis requires accurate dental and rhinological evaluation, including computed tomography (CT). The aim of this study is to investigate a multidisciplinary approach for the treatment of SCDDT by combining endoscopic endonasal surgery (EES) and an intraoral approach on the basis of a preliminary classification system already proposed by other authors...
August 2016: Acta Otorhinolaryngologica Italica
Koichiro Muromachi, Hiroshi Sugiya, Nobuyuki Tani-Ishii
In postnatal dentin formation, odontoblast differentiation occurs in the pulp tissue regenerative process under pathological condition. Odontoblasts and newly differentiated odontoblast-like cells beneath the caries lesion form tertiary dentin and are highly odontogenic. To observe the activity of dentinogenesis occur within the hard tissue, a combination of immunohistological analysis and immunodetection of dentinogenesis specific molecules, such as dentin sialophosphoprotein (DSPP) and/or its cleaved products dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), is a reliable approach...
2017: Methods in Molecular Biology
Aline Priscila Ataíde, Felipe Paiva Fonseca, Alan Roger Santos Silva, Jacks Jorge Júnior, Márcio Ajudarte Lopes, Pablo Agustin Vargas
OBJECTIVES: Oral lesions affecting infants account for approximately 10% of all samples from diagnostic services and studies investigating the distribution of these lesions in pediatrics from different geographic areas are desired to improve the diagnostic knowledge of clinicians. Therefore, the aim of this study is to describe the distribution of oral lesions in a southeastern Brazilian population. METHODS: The oral pathology files of the University of Campinas was retrospectively reviewed for all cases diagnosed from 2000 to 2014 affecting patients 16-years-old and younger...
November 2016: International Journal of Pediatric Otorhinolaryngology
Chun-Chieh Huang, Raghuvaran Narayanan, Satish Alapati, Sriram Ravindran
Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use of exosomes as biomimetic tools to induce stem cell differentiation. Working on the hypothesis that cell-type specific exosomes can trigger lineage-specific differentiation of stem cells, we have evaluated the potential of exosomes derived from dental pulp cells cultured on under growth and odontogenic differentiation conditions to induce odontogenic differentiation of naïve human dental pulp stem cells (DPSCs) and human bone marrow derived stromal cells (HMSCs) in vitro and in vivo...
September 30, 2016: Biomaterials
Swati Shrikant Gotmare, Avinash Tamgadge, Treville Pereira, Anusha Shetty
The keratocystic odontogenic tumor (KCOT), formerly known as odontogenic keratocyst, is a benign developmental odontogenic tumor with many distinguishing clinical and histologic features. Hard tissue deposits, which usually take the form of dystrophic calcifications, cartilaginous tissue, or dentinoid, are uncommon findings in the connective tissue capsule of the KCOT. We report a case of a 33-year-old female with KCOT showing osseous tissue and calcified deposits close to its epithelial lining, which is an extremely rare occurrence...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Sanober Tasnime, Chitrapriya Saxena, Vishal Bansal, Vijay Wadhwan
Odontogenic myxomas are a rare benign odontogenic mesenchymal tumor found exclusively in the tooth-bearing area of the jaw and are usually located centrally in the mandible. Soft tissue localization is rarely seen and is classified as peripheral odontogenic myxoma (POM). POM is slow growing and less aggressive as compared to central myxoma. It has a low recurrence rate, comprises 3-6% of all odontogenic tumors. Only a few cases of POM on maxillary gingiva are reported in the literature. Here, we present an unusual case of primary POM occurring in the gingiva of anterior maxilla in a 14-year-old female patient...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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