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https://www.readbyqxmd.com/read/28721991/angiogenesis-concept-in-odontogenic-keratocyst-a-comparative-study
#1
Donia Sadri, Fatemeh Shahsavari, Sareh Farhadi, Zahra Shahabi, Zahra Mehran
CONTEXT: Recent reports have indicated that angiogenesis possibly affects the biologic behavior of the lesions. AIM: Given the different clinical behaviors of odontogenic keratocyst (OKC), the present study was undertaken to evaluate the concept of angiogenesis in pathogenesis and clinical behavior of OKC. SETTING AND DESIGN: This experimental study was carried out on 22 and 24 samples of OKCs and dentigerous cysts (DCs), respectively. METHODS: Immunohistochemical staining was approached using CD34 and vascular endothelial growth factor (VEGF) antibodies...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28721660/clinicopathologic-and-molecular-characteristics-of-familial-cherubism-with-associated-odontogenic-tumorous-proliferations
#2
Prokopios P Argyris, Rajaram Gopalakrishnan, Ying Hu, Ernst J Reichenberger, Ioannis G Koutlas
Cherubism is a rare autosomal dominant condition affecting the jaws and caused by mutations in the gene encoding for the adapter protein SH3BP2 that maps to chromosome 4p16.3. Cherubism is characterized by symmetrically developing bone lesions in the maxilla and mandible. The lesions have been radiographically and histopathologically well-described. Here, we present a family with cherubism with two of its members featuring odontogenic tumorous proliferations in association with persistent central giant cell lesions (CGCL)...
July 18, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28721317/ameloblastic-fibrodentinoma-a-case-with-varied-patterns-of-dysplastic-dentin
#3
Radhika M Bavle, Sudhakara Muniswammappa, Reshma Venugopal, Amulya S R
Ameloblastic fibrodentinoma is a benign odontogenic tumor belonging to the category of "odontogenic epithelium with odontogenic ectomesenchyme" along with recognition of induction in the form of dentin in atypical or dysplastic forms. The biological behaviour of ameloblastic fibrodentinoma is not very different from ameloblastic fibroma; hence, it is treated similarly by conservative procedures. It is important to understand the histopathogenesis of these rare tumors. Though rare, they are an independent entity awaiting recognition...
June 14, 2017: Curēus
https://www.readbyqxmd.com/read/28717298/ameloblastic-carcinoma-a-rare-malignant-tumour-in-maxillofacial-region
#4
Pushkar Devidas Gawande, Kiran Khande, Gaurav Agrawal, Amita Aditya
Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with poor prognosis. It has an aggressive clinical course with extensive local destruction. It occurs primarily in the mandible. It may clinically present as a cystic lesion with benign clinical feature or as a large mass with ulceration, significant bone resorption and mobility of teeth in the affected region. Reliable evidence of it's biological activity along with extensive local destruction, direct extension of tumor, lymph node involvement and metastasis to various sites (frequently lung) have been reported...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28717292/conservative-management-of-unicystic-ameloblastoma-in-young-patients-a-prospective-single-center-trial-and-review-of-literature
#5
Mitsu Meshram, Lalit Sagarka, Jigar Dhuvad, Sonal Anchlia, Siddharth Vyas, Harsh Shah
AIMS: The study intends to evaluate the clinical outcome of treating young patients of unicystic ameloblastoma, by various conservative treatment modalities such as marsupialization, enucleation with bone curettage and aid in establishing sound treatment guidelines. MATERIALS AND METHODS: A case series of fifteen patients is presented of unicystic ameloblastoma, who presented to our Department over the past 6 years (2010-2015) and conservative method of treatment elected in all the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28717290/to-compare-the-efficacy-of-c-reactive-protein-and-total-leucocyte-count-as-markers-for-monitoring-the-course-of-odontogenic-space-infections
#6
Rishi Bali, Parveen Sharma, Priya Ghanghas, Niti Gupta, Jay Dutt Tiwari, Abhiroop Singh, Nitin Sapra, Disha Goyal
OBJECTIVE: To compare the efficacy of CRP and TLC as markers for monitoring the course of odontogenic space infections (OSI) in 50 patients. METHODS: A Clinical severity scale (CSS) was developed to grade the severity of infections in patients. Blood samples were taken preoperatively and postoperatively at day 1, day 2, day 3 and day 7 for measuring the levels of CRP and TLC. The trends of CRP and TLC were analysed against the CSS. The data was subjected to paired "t" test, ANOVA, Spearman rank correlation, Pearson's bivariate correlation as appropriate...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28716472/the-bone-lid-technique-in-oral-surgery-a-case-series-study
#7
S Sivolella, G Brunello, F Fistarol, E Stellini, C Bacci
The aim of this case series study was to illustrate the bone lid technique implemented using piezoelectric surgery to access mandibular alveolar bone diseases and to assess the clinical and radiographic outcomes. The technique was used to treat 21 consecutive patients with various conditions: cysts in six cases, impacted teeth with associated cysts in nine, keratocystic odontogenic tumours in three, impacted teeth in two, and an endodontic lesion in one. The bone lid was fashioned using piezoelectric surgery and a thin osteotomy insert...
July 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713753/removal-of-multiple-keratocystic-odontogenic-tumors-in-a-nonsyndromic-patient
#8
Artur Cunha Vasconcelos, Paulo Henrique de Souza Castro, Alvaro Henrique Borges, Luiz Evaristo Ricci Volpato
Multiple keratocystic odontogenic tumors are one of the key features of Gorlin-Goltz syndrome. A 15-year-old nonsyndromic female child presented with multiple keratocystic odontogenic tumors. The presence of the tumors was observed in immunological examinations. The images led to the suspicion of Gorlin-Goltz syndrome which was discarded after analyzing the patient's medical history and complementary examinations. Le Fort I osteotomy was opted to access the maxillary tumors favoring visibility and allowing simultaneous bilateral accesses...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713736/using-carnoy-s-solution-in-treatment-of-keratocystic-odontogenic-tumor
#9
Najwa Jameel Alchalabi, Ahmed Maki Merza, Sabah Abdulaziz Issa
AIM: The aim of this study was to assess the treatment of keratocystic odontogenic tumor using enucleation and Carnoy's solution with peripheral ostectomy. MATERIALS AND METHODS: Twenty-nine patients (14 females and 15 males) with age range from 12 to 62 years were included in this study and followed up for 7 years; all the patients were treated in the Department of Oral and Maxillofacial Surgery of the Specialized Surgeries Teaching Hospital (Al-Shaheed Ghazi Al-Hariri Hospital-Medical City, Baghdad, Iraq)...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#10
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Haw-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28709578/insufficient-evidence-to-support-benefits-of-ibuprofen-sodium-dihydrate-over-ibuprofen-acid-to-reduce-pain-in-patients-with-acute-odontogenic-pain
#11
Romina Brignardello-Petersen
No abstract text is available yet for this article.
June 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28706783/the-anecdote-of-viral-etiopathogenia-in-ameloblastoma-and-odontogenic-keratocyst-why-don-t-we-let-it-go
#12
Bacem A E O Khalele
BACKGROUND: Ameloblastoma (AM) and odontogenic Keratocyst (OKC) are destructive odontogenic lesions of the gnathion. Although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in AM and KCOT has been proposed. True to syndromic keratocystic odontogenic tumor (sKCOT) and non-syndromic OKC is the high recurrence rate. OBJECTIVES: Given that shared pathways trailed by AM and by sKCOT/OKC have been suggested, this study, however, contrasts the expression of AM and OKC for viral antibodies...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28706782/immunohistochemical-evaluation-of-podoplanin-in-odontogenic-tumours-cysts-using-anti-human-podoplanin-antibody
#13
Namrata Singhal, Nitin Khanduri, Deepak Kurup, Brijesh Gupta, Pranjan Mitra, Roshani Chawla
BACKGROUND: Odontogenic Cysts & tumors originate through some aberration from the normal pattern of odontogenesis. Ameloblastoma is one of the most frequent intraosseous odontogenic tumors. However it is no longer appropriate to use the diagnosis of ameloblastoma without specifying the type. Varied-clinical entities of ameloblastoma differ in their biologic behaviour. Odontogenic cysts like dentigerous and radicular cysts are less aggressive in nature than odontogenic tumors. Recently, podoplanin commonly used as a lymphatic endothelial marker in cancers has recently been found to play a possible role in odontogenic tumorigenesis also...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28700034/application-of-endoscopy-to-treat-mandibular-keratocystic-odontogenic-tumors
#14
Z Gao, Q W Ni, W Gao, Y P Liu, Q Zhang
The aim of this study was to evaluate the feasibility of endoscopy to remove keratocystic odontogenic tumors (KCOTs) with virtual 3D mandibular images. Fifteen patients (mean age, 40.27±14.58 years) who underwent endoscopic mandibular KCOT enucleation between May 2009 and October 2009 were included. Virtual 3D mandibular reconstructions derived from computed tomography (CT) imaging were generated for all patients. Recurrence and pathological fracture were evaluated as the primary outcome variables at 1 and 12 months after operation...
July 10, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28699252/mesenchymal-stromal-cell-derived-il-6-promotes-epithelial-mesenchymal-transition-and-acquisition-of-epithelial-stem-like-cell-properties-in-ameloblastoma-epithelial-cells
#15
Chunmiao Jiang, Qunzhou Zhang, Rabie M Shanti, Shihong Shi, Ting-Han Chang, Lee Carrasco, Faizan Alawi, Anh D Le
Epithelial-mesenchymal transition (EMT), a biological process associated with cancer stem-like or cancer-initiating cell (CSC) formation, contributes to the invasiveness, metastasis, drug resistance, and recurrence of the malignant tumors; it remains to be determined whether similar processes contribute to the pathogenesis and progression of ameloblastoma, a benign but locally invasive odontogenic neoplasm. Here, we demonstrated that EMT- and stem cell-related genes were expressed in the epithelial islands of the most common histologic variant subtype, the follicular ameloblastoma...
July 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/28691462/odontomas-review-of-the-literature-and-case-reports
#16
C Gervasoni, A Tronchet, S Spotti, S Valsecchi, V Palazzolo, S Riccio, A D Aiuto, L Azzi, A Di Francesco
Odontomas are one of the most common Odontogenic Tumors of the jaw. The exact etiology of odontomas is unknown. Histologically they are composed of various formations of dental tissue (enamel, dentin, cementum and sometimes pulp). In the WHO classification, they are divided into complex odontoma and compound odontoma. Clinically, odontomas are generally asymptomatic and only in rare cases cause swelling, pain, suppuration or bony expansion. Radiologically, the tumor is initially lucent, but with time, it develops small calcifications, which eventually coalesce to form a radiodense lesion with a lucent rim...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28688493/computer-aided-diagnosis-of-periapical-cyst-and-keratocystic-odontogenic-tumor-on-cone-beam-computed-tomography
#17
E Yilmaz, T Kayikcioglu, S Kayipmaz
BACKGROUND AND OBJECTIVES: In this article, we propose a decision support system for effective classification of dental periapical cyst and keratocystic odontogenic tumor (KCOT) lesions obtained via cone beam computed tomography (CBCT). CBCT has been effectively used in recent years for diagnosing dental pathologies and determining their boundaries and content. Unlike other imaging techniques, CBCT provides detailed and distinctive information about the pathologies by enabling a three-dimensional (3D) image of the region to be displayed...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28682278/cervical-thoracic-necrotizing-fasciitis-of-odontogenic-origin-in-a-diabetic-patient-a-case-report
#18
Mateus Barros Cavalcante, Amanda Laísa de Oliveira Lima, Raphael Teixeira Moreira, Emanuel Dias de Oliveira E Silva, Bruno de Lira Castelo Branco
Necrotizing fasciitis (NF) is a severe bacterial infection with rapid and aggressive progression. The infection generally affects individuals with comorbid conditions that lead to immunologic and microvascular deficiencies. It is characterized by necrosis of tissues, mainly in the extremities, trunk, and perineum, and is rarely found in the head and neck. This case report describes the course of NF in a 55-year-old man, highlighting diagnosis, surgical treatment, drug therapy, and supportive measures. The patient, who had chronic alcoholism, systemic arterial hypertension, a smoking habit, and decompensated diabetes (glucose level of 490 mg/dL), was admitted to the hospital with a volume increase in the cervical and thoracic areas with a duration of about 7 days...
July 2017: General Dentistry
https://www.readbyqxmd.com/read/28680851/squamous-cell-carcinoma-arising-within-a-maxillary-odontogenic-keratocyst-a-rare-occurrence
#19
Elnaz Jalali, Elie M Ferneini, Kandasamy Rengasamy, Aditya Tadinada
Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC. Although the initial clinical and radiographic presentation suggested an infection or malignant neoplasm, biopsies revealed an infiltrative well-differentiated SCC contiguous with and arising from the focus of a pre-existing OKC...
June 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28674741/new-tumour-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-odontogenic-and-maxillofacial-bone-tumours
#20
REVIEW
Paul M Speight, Takashi Takata
The latest (4th) edition of the World Health Organization Classification of Head and Neck tumours has recently been published with a number of significant changes across all tumour sites. In particular, there has been a major attempt to simplify classifications and to use defining criteria which can be used globally in all situations, avoiding wherever possible the use of complex molecular techniques which may not be affordable or widely available. This review summarises the changes in Chapter 8: Odontogenic and maxillofacial bone lesions...
July 3, 2017: Virchows Archiv: An International Journal of Pathology
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