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https://www.readbyqxmd.com/read/27920845/the-great-imitator-igg4-periaortitis-masquerading-as-an-acute-aortic-syndrome-on-computed-tomographic-angiography
#1
Drew W Moore, Neil J Hansen, Dominick J DiMaio, William L Harrison
We present the case of a 52-year-old woman who presented to the emergency department with chest and neck pain. Initial cervical spine magnetic resonance imaging shows an abnormal flow void in the left vertebral artery, which prompted a computed tomographic angiogram. This demonstrated a hyperdense thickened ascending aortic wall, which extended into the great vessel origins. Clinically and radiographically interpreted as an acute aortic syndrome and/or intramural hematoma, the patient underwent ascending aortic repair with graft...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920611/products-based-on-olive-oil-betaine-and-xylitol-in-the-post-radiotherapy-xerostomia
#2
Margarita Martín, Alicia Marín, Mario López, Olga Liñán, Felipe Alvarenga, David Büchser, Laura Cerezo
AIM: The objective of this study was determining if the use of products based in olive oil, betaine and xylitol are efficacious to decrease the impact of the dry mouth in the quality of life of the patients with xerostomia due to radiotherapy treatment. BACKGROUND: Following therapeutic irradiation of the head and neck, patients with profound xerostomia have complaints associated with oral dryness, speech, and taste. There is no strong evidence that any topical therapy is effective for relieving the symptom of dry mouth...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27918737/influence-of-bethanechol-on-salivary-parameters-in-irradiated-patients
#3
C Carrara-Cotomacio, L Campos, A Simões, G Chagas-Jaguar, E-M Crosato, F Abreu-Alves
BACKGROUND: Some studies have shown evidence that the prophylactic use of bethanechol chloride (BC) may be useful in preventing the incidence and/or severity of xerostomia (XT). However, the indication of BC in irradiated patients with XT needs to be better characterized. The study aimed to evaluate the influence of BC on XT, salivary flow rate, and salivary composition in patients previously submitted to head and neck radiotherapy. MATERIAL AND METHODS: Forty five irradiated patients complaining of XT used 50 mg/day of BC for 3 months, and the salivary parameters were evaluated in 4 Phases (Before BC therapy, after one month of BC, 2 months of BC, and 3 months of BC)...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27917674/-giant-sialolithiasis-diagnosis-and-management-case-reports
#4
Bálint Tordai, Nóra Stáczer, László Vajta, József Szalma
Sialolithiasis is one of the most frequent form of calcifications in the maxillofacial area. 0.45% of the population is affected by symptoms caused by salivary calculi, though the estimated frequency including asymptomatic form may exceed 1% in adult population. Radiographs presenting a large portion of the maxillofacial region (panoramic radiography, computed tomography) could detect salivary calculi with high accuracy. The size of the sialoliths is usually less than 10 mm in diameter. Salivary calculi larger than 15 mm (considering the largest diameter) are classified as giant sialoliths and most of them are located in the submandibular gland or in its duct...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27916762/induction-of-antibody-response-in-the-oral-cavity-of-dogs-following-intraocular-eye-drop-immunization-with-porphyromonas-gingivalis-cell-lysate-incorporated-in-ph-sensitive-fusogenic-polymer-modified-liposomes
#5
Yosuke Shimizu, Tadashi Iwasaki, Tomoko Tajima, Eiji Yuba, Kenji Kono, Shinobu Watarai
Induction of mucosal immune responses against Porphyromonas gingivalis within the oral cavity of dogs was studied by immunizing with pH-sensitive fusogenic polymer (MGluPG)-modified liposome-associated cell lysate. Dogs immunized with P. gingivalis cell lysate-containing MGluPG-modified liposomes by intraocular (eye drop) route displayed significant levels of P. gingivalis cell lysate-specific serum IgG and IgA as well as mucosal IgA antibodies in saliva secretion. Serum and salivary antibodies generated by intraocularly immunized with MGluPG-modified liposome-associated P...
December 5, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27916659/stronger-hypothalamus-pituitary-adrenal-axis-habituation-predicts-lesser-sensitization-of-inflammatory-response-to-repeated-acute-stress-exposures-in-healthy-young-adults
#6
Myriam V Thoma, Danielle Gianferante, Luke Hanlin, Alexander Fiksdal, Chen Xuejie, Nicolas Rohleder
Effective adjustment of the stress systems to repeated stress is regarded as an adaptive response of the organism facing environmental threats. Given the intertwined relationship between the stress systems and the inflammatory system, it could be expected that inflammatory processes should adapt to repeated stress as well. However, only little is known about adaptational processes of the different components of the immune system in response to repeated stress, and how these might be related to adaptational processes of the hypothalamus-pituitary-adrenal (HPA) axis...
December 1, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27916624/primary-paranasal-sinus-clear-cell-carcinoma-with-ewsr1-atf1-fusion-report-of-two-molecularly-confirmed-cases-exhibiting-unique-histopathology
#7
Jui Lan, Shun-Chen Huang, Yi-Hsien Chen, Wei-Chih Chen, Ying-Tai Jin, Ying-Chou Lu, Chih-Yen Chien, Hsuan-Ying Huang
Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumor of the salivary glands made up of clear cells that form cords and nests in hyalinized stroma. To date, primary HCCCs of the paranasal sinus have not been described. This article presents two cases of HCCC of the maxillary sinus with unusual glandular formation and lymphoplasmacytic stroma in Case 1 and a characteristic solid nest pattern and fibrocellular and hyalinized stroma in Case 2. Immunohistochemical studies excluded myoepithelial origin and sinonasal renal cell-like adenocarcinomas...
December 1, 2016: Human Pathology
https://www.readbyqxmd.com/read/27914919/expressing-a-moth-abcc2-gene-in-transgenic-drosophila-causes-susceptibility-to-bt-cry1ac-without-requiring-a-cadherin-like-protein-receptor
#8
Tristan Stevens, Sisi Song, John B Bruning, Amanda Choo, Simon W Baxter
Bt toxins ingested by insect pests can bind to midgut receptors and cause death, although several steps in this process remain unclear. Multiple Bt toxin receptors have been identified in Lepidoptera, including a cadherin-like protein (CaLP), which is central to several models explaining Bt toxins' mode of action. Mutations in the Plutella xylostella ATP-dependent binding cassette transporter C2 (Px-abcc2), rather than CaLP, are genetically linked with Bt Cry1Ac resistance. Here we expressed Px-abcc2 in Drosophila and performed larval bioassays to determine whether this protein acts as an effective Bt receptor...
November 30, 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#9
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910944/thyroid-sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-a-clinicopathologic-and-molecular-analysis-of-a-distinct-entity
#10
Akeesha A Shah, Kristin La Fortune, Caitlyn Miller, Stacey E Mills, Zubair Baloch, Virginia LiVolsi, Sanja Dacic, Alyssa L Mahaffey, Marina Nikiforova, Yuri E Nikiforov, Raja R Seethala
Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare thyroid neoplasm of uncertain pathogenesis that resembles salivary gland mucoepidermoid carcinoma. This multi-institutional study characterizes the clinicopathologic and molecular features of this tumor by utilizing next-generation sequencing to assess common mutations and gene fusions involved in thyroid carcinogenesis as well as fluorescence in-situ hybridization for MAML2 translocations typical of salivary gland mucoepidermoid carcinoma. Nine cases (6 females and 3 males, mean age: 59 years, range 30-77 years) were identified...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27909455/salivary-testosterone-levels-under-psychological-stress-and-its-relationship-with-rumination-and-five-personality-traits-in-medical-students
#11
Reza Afrisham, Sahar Sadegh-Nejadi, Omid SoliemaniFar, Wesam Kooti, Damoon Ashtary-Larky, Fatima Alamiri, Mohammad Aberomand, Sedigheh Najjar-Asl, Ali Khaneh-Keshi
OBJECTIVE: The purpose of this study was to evaluate the salivary testosterone levels under psychological stress and its relationship with rumination and five personality traits in medical students. METHODS: A total of 58 medical students, who wanted to participate in the final exam, were selected by simple random sampling. Two months before the exam, in the basal conditions, the NEO Inventory short form, and the Emotional Control Questionnaire (ECQ) were completed...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27909404/prefrontal-cortex-activity-is-associated-with-biobehavioral-components-of-the-stress-response
#12
Muriah D Wheelock, Nathaniel G Harnett, Kimberly H Wood, Tyler R Orem, Douglas A Granger, Sylvie Mrug, David C Knight
Contemporary theory suggests that prefrontal cortex (PFC) function is associated with individual variability in the psychobiology of the stress response. Advancing our understanding of this complex biobehavioral pathway has potential to provide insight into processes that determine individual differences in stress susceptibility. The present study used functional magnetic resonance imaging to examine brain activity during a variation of the Montreal Imaging Stress Task (MIST) in 53 young adults. Salivary cortisol was assessed as an index of the stress response, trait anxiety was assessed as an index of an individual's disposition toward negative affectivity, and self-reported stress was assessed as an index of an individual's subjective psychological experience...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27909225/recovery-of-the-immune-system-after-exercise
#13
Jonathan M Peake, Oliver Neubauer, Neil P Walsh, Richard J Simpson
The notion that prolonged, intense exercise causes an 'open window' of immunodepression during recovery after exercise is well accepted. Repeated exercise bouts or intensified training without sufficient recovery may increase the risk of illness. However, except for salivary IgA, clear and consistent markers of this immunodepression remain elusive. Exercise increases circulating neutrophil and monocyte counts, and reduces circulating lymphocyte count during recovery. This lymphopenia results from preferential egress of lymphocyte subtypes with potent effector functions (e...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27908974/effects-of-a-humor-therapy-program-on-stress-levels-in-pediatric-inpatients
#14
Julio C Sánchez, Luis F Echeverri, Manuel J Londoño, Sergio A Ochoa, Andrés F Quiroz, César R Romero, Joaquín O Ruiz
OBJECTIVE: Disease and hospitalization generate stress, which can affect the response to treatment. Humor has been used in many hospitals to decrease stress. The aim of this study was to evaluate the impact of a humor therapy program on stress levels in pediatric inpatients. METHODS: In the first phase, an intervention and a control group were studied over 2 consecutive 3-month periods; the interventions were performed by a team of artists trained in humor therapy...
December 1, 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27908305/abatacept-treatment-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-results-in-a-decrease-of-germinal-centres-in-salivary-gland-tissue
#15
Erlin A Haacke, Bert van der Vegt, Petra M Meiners, Arjan Vissink, Fred K L Spijkervet, Hendrika Bootsma, Frans G M Kroese
OBJECTIVES: The aim of this study was to assess the histopathological changes in parotid gland tissue of primary Sjögren's syndrome (pSS) patients treated with abatacept. METHODS: In all 15 pSS patients included in the open-label Active Sjögren Abatacept Pilot (ASAP, 8 abatacept infusions) study parotid gland biopsies were taken before treatment and at 24 weeks of follow up. Biopsies were analysed for pSS-related histopathological features and placed in context of clini- cal responsiveness as assessed with EULAR Sjögren's syndrome disease activity index (ESSDAI)...
November 12, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27907250/the-transcriptional-co-activator-bob1-is-associated-with-pathologic-b-cell-responses-in-autoimmune-tissue-inflammation
#16
Maria J Levels, Melissa N Van Tok, Tineke Cantaert, Juan D Cañete, Frans G M Kroese, Kristine Germar, Hergen Spits, Dominique L P Baeten, Nataliya G Yeremenko
OBJECTIVE: The molecular mechanisms steering abnormal B cell responses in autoimmune diseases remain poorly understood. In this study we aimed to identify molecular switches controlling pathological B cell responses in rheumatoid arthritis (RA). METHODS: Candidate molecules were identified by gene expression profiling of RA synovitis and validated by qPCR and immunohistochemistry. B cell-specific expression was confirmed by immunofluorescence, immunoblotting and flow cytometry...
December 1, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27907037/reliability-of-potential-pain-biomarkers-in-the-saliva-of-healthy-subjects-inter-individual-differences-and-intersession-variability
#17
Eva M Sobas, Roberto Reinoso, Rubén Cuadrado-Asensio, Itziar Fernández, Miguel J Maldonado, José C Pastor
AIM: Salivary cortisol, α-amylase (sAA), secretory IgA (sIgA), testosterone, and soluble fraction of receptor II of TNFα (sTNFαRII) could serve as objective pain measures, but the normal variability of these potential biomarkers is unknown. PATIENTS & METHODS: Saliva was collected with the passive secretion method from 34, pain-free subjects in two single samples at least 24 hours apart. Biomarker variation and intersession reliability were assessed with the intraclass correlation coefficient (ICC)...
2016: PloS One
https://www.readbyqxmd.com/read/27906987/human-igg-antibody-response-to-aedes-nterm-34kda-salivary-peptide-an-epidemiological-tool-to-assess-vector-control-in-chikungunya-and-dengue-transmission-area
#18
Emmanuel Elanga Ndille, Souleymane Doucoure, Anne Poinsignon, François Mouchet, Sylvie Cornelie, Eric D'Ortenzio, Jean Sébastien DeHecq, Franck Remoue
BACKGROUND: Arboviral diseases are an important public health concerns. Vector control remains the sole strategy to fight against these diseases. Because of the important limits of methods currently used to assess human exposure to Aedes mosquito bites, much effort is being devoted to develop new indicators. Recent studies have reported that human antibody (Ab) responses to Aedes aegypti Nterm-34kDa salivary peptide represent a promising biomarker tool to evaluate the human-Aedes contact...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27906785/210po-in-human-saliva-of-smokeless-tobacco-users
#19
Maria Assunta Meli, Donatella Desideri, Carla Roselli, Laura Feduzi
The occurrence and mobility of Po in oral smokeless tobacco products (STPs) were determined because its effects on human health must be taken into account. This research was subdivided into two parts: determination by alpha spectrometry of the Po activity concentration in 16 oral smokeless tobacco products of different brands purchased in local specialty stores in Europe and evaluation of its percent extraction into an artificial salivary gland during sucking or chewing operations. Polonium-210 was detected in all samples, and its concentrations ranged from 3...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27905825/saliva-volatile-biomarkers-and-profiles
#20
Maciej Milanowski, Paweł Pomastowski, Tomasz Ligor, Bogusław Buszewski
Saliva is an aqueous fluid found in the oral cavity playing fundamental role in the preservation and maintenance of oral health. Apart from higher-molecular-weight constituents it contains volatile organic compounds (VOCs) that may origin from such sources as blood or be result of bacterial metabolism. They can also reach the oral fluid through dissolving of volatiles from breath and consumed foods. Some of them may serve as biomarkers of various diseases, such as dimethyl disulfide (halitosis), pyridine (periodontal disease) and trimethylamine (trimethylaminuria) or occupational exposure...
December 1, 2016: Critical Reviews in Analytical Chemistry
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