keyword
https://read.qxmd.com/read/38215139/risk-factors-and-prognosis-for-the-development-of-acute-kidney-injury-in-patients-using-colistin-in-the-intensive-care-unit-a-retrospective-cohort-study
#21
JOURNAL ARTICLE
Mustafa Deniz, Murat Alişik
Colistin, an antibiotic of polymyxin group, has recently been increasingly used in the treatment of multidrug resistant gram-negative bacteria. However, it has serious adverse effects such as acute kidney injury (AKI). We aimed to determine the factors affecting the development of AKI due to colistin, which has serious adverse effects, such as nephrotoxicity and neurotoxicity. We retrospectively analyzed the data of patients who received colistin for multidrug resistant gram-negative sepsis in adult intensive care units between January 2020 and December 2022...
January 12, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38196698/klotho-activation-of-nrf2-inhibits-the-ferroptosis-signaling-pathway-to-ameliorate-sepsis-associated-acute-kidney-injury
#22
JOURNAL ARTICLE
Pan Zhou, Congcong Zhao, Yuhong Chen, Xuefang Liu, Chunxue Wu, Zhenjie Hu
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a common complication of sepsis and greatly increases patient mortality. Recombinant human Klotho protein (Klotho) is a protective protein that can be secreted by the kidney. The aim of this study was to explore the protective effect of Klotho on SA-AKI and its molecular mechanism. METHODS: In vivo , a mouse SA-AKI model was constructed by cecum ligation perforation (CLP). In vitro , a human renal tubular cell epithelial cell line (HK2) was induced with lipopolysaccharide (LPS) in the SA-AKI model...
December 31, 2023: Translational Andrology and Urology
https://read.qxmd.com/read/38169549/protective-role-of-mavs-signaling-for-murine-lipopolysaccharide-induced-acute-kidney-injury
#23
JOURNAL ARTICLE
Trang Anh Thi Tran, Yasunori Iwata, Linh Thuy Hoang, Shinji Kitajima, Shiori Yoneda-Nakagawa, Megumi Oshima, Norihiko Sakai, Tadashi Toyama, Yuta Yamamura, Hiroka Yamazaki, Akinori Hara, Miho Shimizu, Keisuke Sako, Taichiro Minami, Takahiro Yuasa, Keisuke Horikoshi, Daiki Hayashi, Sho Kajikawa, Takashi Wada
Despite treatment advances, acute kidney injury (AKI)-related mortality rates are still high in hospitalized adults, often due to sepsis. Sepsis and AKI could synergistically worsen the outcomes of critically ill patients. TLR4 signaling and mitochondrial antiviral signaling protein (MAVS) signaling are innate immune responses essential in kidney diseases, but their involvement in sepsis-associated AKI (SA-AKI) remains unclear. We studied the role of MAVS in kidney injury related to the TLR4 signaling pathway using a murine LPS-induced AKI model in wild-type and MAVS-knockout mice...
January 1, 2024: ImmunoHorizons
https://read.qxmd.com/read/38163633/fibroblastic-reticular-cell-derived-exosomes-are-a-promising-therapeutic-approach-for-septic-acute-kidney-injury
#24
JOURNAL ARTICLE
Yiming Li, Chang Hu, Pan Zhai, Jing Zhang, Jun Jiang, Jinmeng Suo, Bo Hu, Jing Wang, Xiaocheng Weng, Xiang Zhou, Timothy R Billiar, John A Kellum, Meihong Deng, Zhiyong Peng
Sepsis-induced acute kidney injury (S-AKI) is highly lethal, and effective drugs for treatment are scarce. Previously, we reported the robust therapeutic efficacy of fibroblastic reticular cells (FRCs) in sepsis. Here, we demonstrate the ability of FRC-derived exosomes (FRC-Exos) to improve C57BL/6 mouse kidney function following cecal ligation and puncture-induced sepsis. In vivo imaging confirmed that FRC-Exos homed to injured kidneys. RNA-Seq analysis of FRC-Exo-treated primary kidney tubular cells (PKTCs) revealed that FRC-Exos influenced PKTC fate in the presence of lipopolysaccharide (LPS)...
December 30, 2023: Kidney International
https://read.qxmd.com/read/38159412/perioperative-acute-kidney-injury-the-renoprotective-effect-and-mechanism-of-dexmedetomidine
#25
REVIEW
Xiong Gao, Yaohua Wu
Dexmedetomidine (DEX) is a highly selective and potent α2-adrenoceptor (α2-AR) agonist that is widely used as a clinical anesthetic to induce anxiolytic, sedative, and analgesic effects. In recent years, a growing body of evidence has demonstrated that DEX protects against acute kidney injury (AKI) caused by sepsis, drugs, surgery, and ischemia-reperfusion (I/R) in organs or tissues, indicating its potential role in the prevention and treatment of AKI. In this review, we summarized the evidence of the renoprotective effects of DEX on different models of AKI and explored the mechanism...
February 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38156780/risk-factors-for-postoperative-acute-kidney-injury-after-major-abdominal-surgery
#26
JOURNAL ARTICLE
Marija Milinkovic, Zeljko Lausevic, Milica Kravljaca, Voin Brkovic, Danica Stanic, Nina Rajovic, Jelena Nikolic, Mirjana Lausevic
AIM: Acute kidney injury (AKI) worsens the outcome in a significant number of hospitalized patients. Risk models mainly address cardiac surgery, while significantly less attention is paid to AKI after major abdominal surgery (MAS). This study aims to evaluate the incidence, along with risk factors, and intrahospital outcomes of AKI after MAS. MATERIAL AND METHODS: Our retrospective study included 200 adult patients treated with MAS (in the same institution). Exclusion criteria were obstructive nephropathy, contrast-induced nephropathy, and dialysis dependence whether due to end-stage renal disease (ESRD) or AKI before MAS...
December 29, 2023: Clinical Nephrology
https://read.qxmd.com/read/38154960/aurantio-obtusin-exerts-an-anti-inflammatory-effect-on-acute-kidney-injury-by-inhibiting-nf-%C3%AE%C2%BAb-pathway
#27
JOURNAL ARTICLE
Haiyan Xiang, Yun Zhang, Yan Wu, Yaling Xu, Yuanhao Hong
Acute kidney injury (AKI) is one of the major complications of sepsis. Aurantio-obtusin (AO) is an anthraquinone compound with antioxidant and anti-inflammatory activities. This study was developed to concentrate on the role and mechanism of AO in sepsis-induced AKI. Lipopolysaccharide (LPS)-stimulated human renal proximal tubular epithelial cells (HK-2) and BALB/c mice receiving cecal ligation and puncture (CLP) surgery were used to establish in vitro cell model and in vivo mouse model. HK-2 cell viability was measured using MTT assays...
January 1, 2024: Korean Journal of Physiology & Pharmacology
https://read.qxmd.com/read/38149613/melittin-alleviates-sepsis-induced-acute-kidney-injury-by-promoting-gpx4-expression-to-inhibit-ferroptosis
#28
JOURNAL ARTICLE
Hongyan Zan, Jizheng Liu, Meixia Yang, Honghui Zhao, Chunyan Gao, Yunyan Dai, Zhiming Wang, Hongxuan Liu, Yunfei Zhang
OBJECTIVES: Melittin, the main component of bee venom, is a natural anti-inflammatory substance, in addition to its ability to fight cancer, antiviral, and useful in diabetes treatment. This study seeks to determine whether melittin can protect renal tissue from sepsis-induced damage by preventing ferroptosis and explore the protective mechanism. METHODS: In this study, we investigated the specific protective mechanism of melittin against sepsis-induced renal injury by screening renal injury indicators and ferroptosis -related molecules and markers in animal and cellular models of sepsis...
December 2024: Redox Report: Communications in Free Radical Research
https://read.qxmd.com/read/38135199/malvidin-promotes-pgc-1%C3%AE-nrf2-signaling-to-attenuate-the-inflammatory-response-and-restore-mitochondrial-activity-in-septic-acute-kidney-injury
#29
JOURNAL ARTICLE
Hui Fan, Yong Sun, Xiao Zhang, Yao Xu, Yuanyuan Ming, Le Zhang, Panpan Zhao
Acute kidney injury (AKI) in sepsis is a vital and dangerous organ failure caused by an infection-induced dysregulation of the host reaction. Malvidin possesses significant anti-inflammatory and antioxidant bioactivities. This study explored the critical roles of malvidin in sepsis AKI and the crosstalk among mitochondrial function, nucleotide-binding oligomerization-like receptor 3 (NLRP3) inflammasome and nuclear factor erythroid 2 (Nrf2) signaling pathway. First, C57BL/6 mice were administered lipopolysaccharide intraperitoneally for 6 h to create an AKI model of sepsis...
December 20, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/38135115/the-effects-of-antibiotic-therapy-on-neonatal-sepsis-associated-acute-kidney-injury
#30
JOURNAL ARTICLE
Irina B Pevzner, Anna A Brezgunova, Vasily A Popkov, Mikhail Y Sintsov, Nadezda V Andrianova, Ljubava D Zorova, Denis N Silachev, Artem A Burov, Yulia L Podurovskaya, Dmitry B Zorov, Egor Y Plotnikov, Gennady T Sukhikh
AIM: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost always involves antibiotic therapy, which by itself may cause some adverse effects, including nephrotoxicity. We analyzed the mutual effect of antibiotic therapy and sepsis on AKI in an experimental and clinical study in neonatal infants and rats...
December 20, 2023: Life Sciences
https://read.qxmd.com/read/38134592/saa3-promotes-pro-inflammatory-macrophage-differentiation-and-contributes-to-sepsis-induced-aki
#31
JOURNAL ARTICLE
Yi Peng, Yan Fang, Zhilan Li, Chenxi Liu, Weiru Zhang
Sepsis-induced acute kidney injury (SAKI) is a life-threatening condition with complex pathophysiology, often exacerbated by immune cell dysregulation. In this comprehensive study, we leverage publicly available single-cell RNA sequencing (scRNA-seq) datasets to unravel the intricate immune responses occurring during SAKI, shedding light on macrophages as critical players. Specifically, we identify Saa3, a gene primarily expressed in macrophages, as a potent pro-inflammatory cytokine in SAKI. Saa3hi Ccl2hi monocyte-derived infiltrated macrophages (IMs) emerge as a central effector subset, fostering inflammation, and directly engaging with renal cells...
December 21, 2023: International Immunopharmacology
https://read.qxmd.com/read/38058075/lncrna-miat-modulates-lps-induced-acute-kidney-injury-via-becn1-dependent-autophagy-by-interacting-with-ptbp1
#32
JOURNAL ARTICLE
Min Xu, Yanyan Zhou
BACKGROUND: Autophagy plays critical adaptive and nonadaptive roles in the pathogenesis of Sepsis-associated acute kidney injury (Sepsis-AKI). However, it remains unknown whether myocardial infarction associated transcript (MIAT) is involved in the process of autophagy in Sepsis-AKI. This study aimed to explore the exact association between MIAT1 and Beclin 1 (BECN1)-mediated autophagy in Sepsis-AKI in vitro . METHODS: HK-2 (human renal tubular epithelial cell line) cells were stimulated by lipopolysaccharide (LPS) to construct a septic kidney injury cell model in vitro ...
December 2023: Discovery Medicine
https://read.qxmd.com/read/38038826/disseminated-intravascular-coagulation-is-strongly-associated-with-severe-acute-kidney-injury-in-patients-with-septic-shock
#33
JOURNAL ARTICLE
Julie Helms, Hamid Merdji, Sébastien Loewert, François Severac, Alexandra Monnier, Julian Kaurin, Anaïs Curtiaud, Ferhat Meziani, Julien Demiselle
BACKGROUND: Disseminated intravascular coagulation (DIC) worsens the prognosis of septic shock and contributes to multiple organ failure. To date, no data linking DIC and acute kidney injury (AKI) occurrence, severity, and evolution in this setting are available. We aimed at analyzing the association between AKI occurrence, severity and evolution in patients with septic shock-induced DIC. In a prospective monocentric cohort study, consecutive patients, 18 years and older, admitted in the ICU of Strasbourg University Hospital in the setting of systemic hypotension requiring vasopressor related to an infection, without history of terminal chronic kidney disease were eligible...
December 1, 2023: Annals of Intensive Care
https://read.qxmd.com/read/38016342/quinacrine-a-pla2-inhibitor-alleviates-lps-induced-acute-kidney-injury-in-rats-involvement-of-tlr4-nf-%C3%AE%C2%BAb-tnf-%C3%AE-mediated-signaling
#34
JOURNAL ARTICLE
Selim Çomaklı, Sefa Küçükler, Şükrü Değirmençay, İsmail Bolat, Selçuk Özdemir
Acute Kidney Injury (AKI) is a major factor in sepsis-related mortality and may occur due to lipopolysaccharide (LPS), an endotoxin produced by gram-negative bacteria that triggers a systemic acute inflammatory response. Quinacrine's (QC) renoprotective properties in sepsis and the underlying mechanism, however, are still not fully understood. This study was done to investigate the anti-inflammatory, antioxidative, and anti-apoptotic effects of QC, a phospholipase A2 (PLA2) inhibitor, against LPS-induced AKI...
November 27, 2023: International Immunopharmacology
https://read.qxmd.com/read/38010069/coagulopathy-parameters-predictive-of-outcomes-in-sepsis-induced-acute-respiratory-distress-syndrome-a-sub-analysis-of-the-two-prospective-multicenter-cohort-studies
#35
JOURNAL ARTICLE
Tadashi Matsuoka, Seitaro Fujishima, Junchi Sasaki, Satoshi Gando, Daizoh Saitoh, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Atsushi Shiraishi, Toshihiko Mayumi, Joji Kotani, Naoshi Takeyama, Ryosuke Tsuruta, Kiyotsugu Takuma, Norio Yamashita, Shin-Ichiro Shiraishi, Hiroto Ikeda, Yasukazu Shiino, Takehiko Tarui, Taka-Aki Nakada, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yuichiro Sakamoto, Akiyoshi Hagiwara, Tomohiko Masuno, Masashi Ueyama, Satoshi Fujimi, Kazuma Yamakawa, Yutaka Umemura
BACKGROUND: Although coagulopathy is often observed in acute respiratory distress syndrome (ARDS), its clinical impact remains poorly understood. OBJECTIVES: This study aimed to clarify the coagulopathy parameters that are clinically applicable for prognostication and to determine anticoagulant indications in sepsis-induced ARDS. METHOD: This study enrolled patients with sepsis-derived ARDS from two nationwide multicenter, prospective observational studies...
November 16, 2023: Shock
https://read.qxmd.com/read/38010029/knockdown-of-circ_0114428-alleviates-lps-induced-hk2-cell-apoptosis-and-inflammation-injury-via-targeting-mir-215-5p-traf6-nf-%C3%AE%C2%BAb-axis-in-septic-acute-kidney-injury
#36
JOURNAL ARTICLE
Yan Li, Chunmei Zhang, Zhongyan Zhao
BACKGROUND: Sepsis is a systemic inflammatory disease that can cause multiple organ damage. Circular RNAs (circRNAs) have been reported to play a regulatory role in sepsis-induced acute kidney injury (AKI), however, the role of circ_0114428 has not been studied. METHODS: In this study, HK2 cells were treated with different concentrations of lipopolysaccharide (LPS) to induce cell damage, and then the expressions of circ_0114428, microRNA-215-5p (miR-215-5p), tumor necrosis factor receptor-associated factor 6 (TRAF6) were detected by quantitative real-time polymerase chain reaction (qRT-PCR), and western blot examined the Bax and Cleaved-caspase-3 proteins...
November 16, 2023: Shock
https://read.qxmd.com/read/38000722/dexmedetomidine-alleviates-renal-tubular-ferroptosis-in-sepsis-associated-aki-by-keap1-regulating-the-degradation-of-gpx4
#37
JOURNAL ARTICLE
Jiarou Li, Yansong Liu, Jingjing Bai, Tiantian Liu, Xionghai Qin, Tianyou Hu, Sicong Wang, Yunlong Li, Shanpeng Cui, Zhen Quan, Yiming Luo, Junbo Zheng, Hongliang Wang
Sepsis-associated acute kidney injury (SA-AKI) has a high mortality rate and lacks effective targeted treatment. We applied lipopolysaccharides-induced injury models in human and mouse renal tubular epithelial cells, and at the same time, we selected a commonly used sedative drug, dexmedetomidine, to investigate its potential for renal protection. We found a significant increase in the expression level of HSP90, and the interaction with glutathione peroxidase 4 (GPX4) led to autophagic degradation of GPX4, triggering ferroptosis...
November 22, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37994026/circ_0006944-aggravates-lps-induced-hk2-cell-injury-via-modulating-mir-205-5p-ubl4a-pathway
#38
JOURNAL ARTICLE
Fan Zhou, Dong Liu, Junwei Ye, Bingqi Li
Circular RNAs (circRNAs) has been manifested to be involved in the development of human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, the function and mechanism of circ_0006944 in SA-AKI has not been validated. Lipopolysaccharide (LPS) was utilised to induce AKI cell model. Levels of genes and proteins were monitored by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Cell counting kit 8 assay, EdU assay and flow cytometry were exploited to estimate cell proliferation and apoptosis...
December 2023: Autoimmunity
https://read.qxmd.com/read/37987131/-predictive-value-of-pulse-infusion-index-in-the-short-term-prognosis-of-patients-with-sepsis-induced-acute-kidney-injury
#39
JOURNAL ARTICLE
Jue Zhang, Sipan Wang, Nan Chen, Jun Jin, Yi Li
OBJECTIVE: To investigate the predictive value of pulse infusion index (PPI) in the short-term prognosis of patients with sepsis-induced acute kidney injury (AKI). METHODS: A retrospective cohort study was conducted. The clinical data of patients with sepsis-induced AKI admitted to intensive care unit (ICU) of the First Affiliated Hospital of Soochow University from July 2021 to December 2022 were enrolled. The basic information of the patients were collect, including age, gender, site of infection, underlying disease, mean arterial pressure (MAP) and heart rate (HR) at admission, as well as the use of mechanical ventilation and vasoactive drugs, and norepinephrine (NE) dosage...
November 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/37980806/effects-and-mechanisms-of-frehmaglutin-d-and-rehmaionoside-c-improve-lps-induced-acute-kidney-injury-through-the-estrogen-receptor-mediated-tlr4-pathway-in-vivo-and-in-vitro
#40
JOURNAL ARTICLE
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
BACKGROUND: Sepsis-induced acute kidney injury (S-AKI) is an inflammatory disease with sex differences and there has no effective drugs to cure it. Frehmaglutin D (Fre D) and rehmaionoside C (Reh C) are two violetone compounds with estrogenic activity isolated from Rehmannia glutinosa. However, whether these two drugs exert protective effects on S-AKI through their estrogen-like activity are unclear. PURPOSE: This study aimed to explore the effects and mechanisms of Fre D and Reh C on lipopolysaccharide (LPS)-induced S-AKI through the estrogen receptor pathway in vivo and in vitro and to explore the interaction between ER and TLR4 for the first time...
November 14, 2023: Phytomedicine
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