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https://www.readbyqxmd.com/read/28445803/jetvalve-rapid-manufacturing-of-biohybrid-scaffolds-for-biomimetic-heart-valve-replacement
#1
Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A Goss, Simon P Hoerstrup, Kevin Kit Parker
Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28445052/facile-preparation-of-drug-loaded-tristearin-encapsulated-superparamagnetic-iron-oxide-nanoparticles-using-coaxial-electrospray-processing
#2
Manoochehr Rasekh, Zeeshan Ahmad, Richard Barrie Michael Cross, Javier Hernández Gil, James D E T Wilton-Ely, Philip W Miller
Naturally occurring polymers are promising biocompatible materials that have many applications for emerging therapies, drug delivery systems and diagnostic agents. The handling and processing of such materials still constitutes a major challenge which can limit the full exploitation of their properties. This study explores an ambient environment processing technique: coaxial electrospray (CO-ES) to encapsulate genistein (an isoflavonoid and model drug), superparamagnetic iron oxide nanoparticles (SPIONs, 10-15 nm) and a fluorophore (BODIPY) into a layered (triglyceride tristearin shell) particulate system, with a view to constructing a theranostic agent...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444555/evaluating-the-effectiveness-of-a-novel-atomized-liquid-needle-free-transdermal-delivery-system
#3
Yi-Huei Huang, Chieh-Shen Hu, Yi-Jhen Ke, Chiao-Hsi Chiang, Po-Da Hong, Ming-Kung Yeh
Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient's body; however, the mechanism and efficiency of the system are unclear. This study explored the shot delivery pressure, penetration depth, and cumulative amount of permeation of this system. This system was used to deliver 0.5% (w/v) methylene blue to agarose phantoms at various shot delivery pressures...
April 25, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28444164/vena-contracta-area-for-severity-grading-in-functional-and-degenerative-mitral-regurgitation-a-transoesophageal-3d-colour-doppler-analysis-in-500-patients
#4
Björn Goebel, Roland Heck, Ali Hamadanchi, Sylvia Otto, Torsten Doenst, Christian Jung, Alexander Lauten, Hans R Figulla, P Christian Schulze, Tudor C Poerner
Aims: Vena contracta area (VCA3D), derived by 3D colour Doppler echocardiography, has already been validated against cardiac magnetic resonance imaging, but the number of clinical studies to define cut-off values for grading of mitral regurgitation (MR) is limited. Aim of the study was to assess VCA3D in a large population of patients with functional (FMR) and degenerative MR (DMR). Methods and results: Transoesophageal echocardiography was performed in 500 patients with MR...
April 21, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28444160/echo-doppler-estimation-of-left-ventricular-filling-pressure-results-of-the-multicentre-eacvi-euro-filling-study
#5
Patrizio Lancellotti, Maurizio Galderisi, Thor Edvardsen, Erwan Donal, Georg Goliasch, Nuno Cardim, Julien Magne, Sara Laginha, Andreas Hagendorff, Trine F Haland, Lars Aaberge, Christophe Martinez, Antonio Rapacciuolo, Ciro Santoro, Federica Ilardi, Adriana Postolache, Raluca Dulgheru, Anca D Mateescu, Carmen C Beladan, Dan Deleanu, Stella Marchetta, Vincent Auffret, Ehud Schwammenthal, Gilbert Habib, Bogdan A Popescu
Aims: The present Euro-Filling report aimed at comparing the diagnostic accuracy of the 2009 and 2016 echocardiographic grading algorithms for predicting invasively measured left ventricular filling pressure (LVFP). Method and results: A total of 159 patients who underwent simultaneous evaluation of echo estimates of LVFP and invasive measurements of LV end-diastolic pressure (LVEDP) were enrolled at nine EACVI centres. Thirty-nine (25%) patients had a reduced LV ejection fraction (<50%), 77 (64%) were in NYHA ≥ II, and 85 (53%) had coronary artery disease...
April 22, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28443888/sugar-peptidic-bond-interactions-spectroscopic-characterization-of-a-model-system
#6
Ander Camiruaga, Imanol Usabiaga, Aran Insausti, Iker León, José A Fernández
Sugars are small carbohydrates which play numerous roles in living organisms such as storage of energy or as structural components. Modifications of specific sites within the glycan chain can modulate a carbohydrate's overall biological function as it happens with nucleic acids and proteins. Hence, identifying discrete carbohydrate modifications and understanding their biological effects is essential. A study of such processes requires of a deep knowledge of the interaction mechanism at the molecular level...
April 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28443670/cooperativity-in-alcohol-nitrogen-complexes-understanding-cryomatrices-through-slit-jet-expansions
#7
Sönke Oswald, Mareike Wallrabe, Martin A Suhm
FTIR spectroscopy of supersonic expansions is used to characterize alcohol dimers with one, two, and several nitrogen molecules attached to them. The nitrogen coating causes progressive spectral downshifts of the OH stretching fundamentals which are related to and explain matrix isolation shifts. Comparison of methanol, tert-butyl alcohol and ethanol as well as deuteration of methanol assist in the assignment. Alcohol monomers and trimers are significantly more resistant to nitrogen coating due to a lack of cooperativity and dangling bonds, respectively...
April 26, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28443630/accelerating-recovery-from-jet-lag-prediction-from-a-multi-oscillator-model-and-its-experimental-confirmation-in-model-animals
#8
Hiroshi Kori, Yoshiaki Yamaguchi, Hitoshi Okamura
The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one's internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such misalignments are accompanied by sleep disturbances and gastrointestinal distress. Repeated exposure to jet lag and rotating shift work increases the risk of lifestyle-related diseases, such as cardiovascular complaints and metabolic insufficiencies...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441897/return-to-work-after-mild-to-moderate-stroke-work-satisfaction-and-predictive-factors
#9
Jet van der Kemp, Willeke J Kruithof, Tanja C W Nijboer, Coen A M van Bennekom, Caroline van Heugten, Johanna M A Visser-Meily
A large proportion of stroke patients are unable to return to work (RTW), although figures vary greatly. A total of 121 mild-to-moderate stroke patients, who had a paid job at the time of their stroke were included (a) to quantify RTW and work satisfaction one-year post-stroke (using the Utrecht Scale for Evaluation of Rehabilitation-Participation) and (b) to determine factors predicting RTW post-stroke, based on stroke-related, personal and neuropsychological variables. Half of the patients were not in work (28%) or were working less (22%) than pre-stroke...
April 26, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28438000/development-of-limited-view-and-three-dimensional-reconstruction-method-for-analysis-of-electrohydrodynamic-jetting-behavior
#10
Yeonghyeon Gim, Dong Ho Shin, Do Yoon Moh, Han Seo Ko
For an electrohydrodynamic (EHD) jet, variables such as the direction of the meniscus and the ejection stability need to be analyzed. Thus, the EHD jet should be observed three-dimensionally (3D) because the variables can only be obtained in the 3D field, especially in unstable modes. However, if the 3D field is reconstructed from multi-directional binary images, eliminating reconstruction errors caused by invisible areas is almost impossible, even when using a tomographic technique. To solve this problem, a new 3D reconstruction method including an ellipse estimation was developed in this study...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28436022/ventilation-via-the-2-4%C3%A2-mm-internal-diameter-tritube-%C3%A2-with-cuff%C3%A2-new-possibilities-in-airway-management
#11
REVIEW
M S Kristensen, M W P de Wolf, L S Rasmussen
BACKGROUND: A small tube may facilitate tracheal intubation and improve surgical access. We describe our initial experience with the Tritube(®) that is a novel cuffed endotracheal tube with a 2.4 mm internal diameter. METHODS: The Tritube(®) was used in seven adult Ear-Nose-and Throat surgical patients with airway narrowing or whose surgical access was facilitated by this small-bore endotracheal tube. Ventilation through Tritube(®) is performed with the manually operated Ventrain(®) -ventilator that allows active suctioning during expiration, therefore facilitating normoventilation through small diameter airways...
April 23, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28435031/clinical-outcome-associated-with-the-use-of-different-inhalation-method-with-and-without-humidification-in-asthmatic-mechanically-ventilated-patients
#12
Islam O F Moustafa, Muhammad H E ElHansy, Moataz Al Hallag, James B Fink, Patricia Dailey, Hoda Rabea, Mohamed E A Abdelrahim
BACKGROUND: Inhaled-medication delivered during mechanical-ventilation is affected by type of aerosol-generator and humidity-condition. Despite many in-vitro studies related to aerosol-delivery to mechanically-ventilated patients, little has been reported on clinical effects of these variables. The aim of this study was to determine effect of humidification and type of aerosol-generator on clinical status of mechanically ventilated asthmatics. METHOD: 72 (36 females) asthmatic subjects receiving invasive mechanical ventilation were enrolled and assigned randomly to 6 treatment groups of 12 (6 females) subjects each received, as possible, all inhaled medication using their assigned aerosol generator and humidity condition during delivery...
April 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28433025/a-combined-theoretical-and-experimental-study-of-phenol-acetylene-n-n-%C3%A2-7-clusters
#13
Gurmeet Singh, Apurba Nandi, Shridhar R Gadre, Takashi Chiba, Asuka Fujii
Structures and vibrational spectra of phenol-(acetylene)n (Ph(Ac)n) clusters are studied by a combination of theoretical calculations and infrared (IR) spectroscopy. The molecular electrostatic potential features are utilized for generating trial geometries of the medium-sized Ph(Ac)n (n = 1, 2, 4, 6, and 7) clusters. These initial geometries are subjected to geometry optimization within the second-order Møller-Plesset (MP2) theory, employing correlation consistent aug-cc-pVDZ (aVDZ) basis set. Minimal nature of the reported structures is confirmed by doing vibrational frequency run at MP2/aVDZ level of theory using full calculations for n = 1 and 2 and employing grafting based molecular tailoring approach for the n = 4, 6, and 7...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28433021/to-kink-or-not-a-search-for-long-chain-cumulenones-using-microwave-spectral-taxonomy
#14
Michael C McCarthy, Luyao Zou, Marie-Aline Martin-Drumel
A systematic search for carbon-chain cumulenones beyond H2C4O has been undertaken using microwave spectral taxonomy in combination with a pulsed jet discharge source. No evidence was found for the C2υ isomer of H2C5O or its longer derivatives, but HC(O)C4H, the longer variant of propynal, HC(O)CCH, was identified instead. Its rotational and leading centrifugal distortion constants have been derived to high accuracy from detection of both a- and b-type lines; those below 40 GHz were measured using a Fabry-Perot cavity, while lines between 40 and 72 GHz were recorded by double resonance techniques...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432354/structural-and-functional-analysis-of-lysozyme-after-treatment-with-dielectric-barrier-discharge-plasma-and-atmospheric-pressure-plasma-jet
#15
Sooho Choi, Pankaj Attri, Inhwan Lee, Jeongmin Oh, Ji-Hye Yun, Ji Hoon Park, Eun Ha Choi, Weontae Lee
The variation in the biological function of proteins plays an important role in plasma medicine and sterilization. Several non-thermal plasma sources with different feeding gases are used worldwide for plasma treatment, including dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) as the most commonly used sources. Therefore, in the present work, we used both DBD and APPJ plasma sources with N2 and air as feeding gases to evaluate the effects on the structural, thermodynamic, and activity changes of enzymes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430608/adrenalectomy-abolishes-hypergravity-induced-gastric-acid-hyposecretion
#16
Kiyong Na, Hyun-Soo Kim
Jet fighter pilots experience high gravitational acceleration forces in the cephalocaudal direction (+Gz), causing severe stress. Stress affects different physiological functions of the gastrointestinal tract. Although the effects of exposure to hypergravity on cardiovascular and cerebral functions have been the subject of numerous studies, crucial information regarding potential pathophysiological alterations following hypergravity exposure in the gastrointestinal tract is lacking. We recently documented a significant decrease in gastric secretory activity in rats after acute exposure to hypergravity...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429326/wax-ester-fermentation-and-its-application-for-biofuel-production
#17
Hiroshi Inui, Takahiro Ishikawa, Masahiro Tamoi
In Euglena cells under anaerobic conditions, paramylon, the storage polysaccharide, is promptly degraded and converted to wax esters. The wax esters synthesized are composed of saturated fatty acids and alcohols with chain lengths of 10-18, and the major constituents are myristic acid and myristyl alcohol. Since the anaerobic cells gain ATP through the conversion of paramylon to wax esters, the phenomenon is named "wax ester fermentation". The wax ester fermentation is quite unique in that the end products, i...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28427145/uncoupling-genotoxic-stress-responses-from-circadian-control-increases-susceptibility-to-mammary-carcinogenesis
#18
Mingzhu Fang, Pamela A Ohman Strickland, Hwan-Goo Kang, Helmut Zarbl
We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer 344 (F344) rats by enhancing NAD+-dependent SIRT1 activity, restoring circadian expression of Period 2 (Per2) and circadian controlled genes. Here, we show that compared to the genetically resistant Copenhagen (COP) rat strain, mammary glands of the F344 rats have a 4-hour phase delay in circadian expression of Per2. Consequently, F344 rats failed to increase SIRT1 activity and circadian expression of Per2 and DDRR genes after exposure to NMU...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427010/leveraging-microbial-biosynthetic-pathways-for-the-generation-of-drop-in-biofuels
#19
REVIEW
Amin Zargar, Constance B Bailey, Robert W Haushalter, Christopher B Eiben, Leonard Katz, Jay D Keasling
Advances in retooling microorganisms have enabled bioproduction of 'drop-in' biofuels, fuels that are compatible with existing spark-ignition, compression-ignition, and gas-turbine engines. As the majority of petroleum consumption in the United States consists of gasoline (47%), diesel fuel and heating oil (21%), and jet fuel (8%), 'drop-in' biofuels that replace these petrochemical sources are particularly attractive. In this review, we discuss the application of aldehyde decarbonylases to produce gasoline substitutes from fatty acid products, a recently crystallized reductase that could hydrogenate jet fuel precursors from terpene synthases, and the exquisite control of polyketide synthases to produce biofuels with desired physical properties (e...
April 17, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28426069/gradual-modification-of-ito-particle-s-crystal-structure-and-optical-properties-by-pulsed-uv-laser-irradiation-in-a-free-liquid-jet
#20
Marcus Lau, Thomas Straube, A Vikas Aggarwal, Ulrich Hagemann, Bernardo de Oliveira Viestel, Nils Hartmann, Torsten Textor, Harald Lutz, Jochen S Gutmann, Stephan Barcikowski
Indium tin oxide (ITO) particle coatings are known for high transparency in the visible, good conductive properties and near-infrared absorption. These properties depend on ITO particle's stoichiometric composition, defects and size. Here we present a method to gradually change ITO particle's optical properties by a simple and controlled laser irradiation process. The defined irradiation process and controlled energy dose input allows one to engineer the absorption and transmission of coatings made from these particles...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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