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https://www.readbyqxmd.com/read/27914033/l-carnitine-simvastatin-reduces-lipoprotein-a-levels-compared-with-simvastatin-monotherapy-a-randomized-double-blind-placebo-controlled-study
#1
M Florentin, M S Elisaf, C V Rizos, V Nikolaou, E Bilianou, C Pitsavos, E N Liberopoulos
Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. There are currently limited therapeutic options to lower Lp(a) levels. L-Carnitine has been reported to reduce Lp(a) levels. The aim of this study was to compare the effect of L-carnitine/simvastatin co-administration with that of simvastatin monotherapy on Lp(a) levels in subjects with mixed hyperlipidemia and elevated Lp(a) concentration. Subjects with levels of low-density lipoprotein cholesterol (LDL-C) >160 mg/dL, triacylglycerol (TAG) >150 mg/dL and Lp(a) >20 mg/dL were included in this study...
December 2, 2016: Lipids
https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#2
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895474/efficacy-of-l-carnitine-supplementation-on-frailty-status-and-its-biomarkers-nutritional-status-and-physical-and-cognitive-function-among-prefrail-older-adults-a-double-blind-randomized-placebo-controlled-clinical-trial
#3
M Badrasawi, Suzana Shahar, A M Zahara, R Nor Fadilah, Devinder Kaur Ajit Singh
BACKGROUND: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency, including L-carnitine, has been proposed to be associated with its pathophysiology. Nevertheless, the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus, this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function, cognition, and nutritional status among prefrail older adults in Klang Valley, Malaysia...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27885554/short-term-effects-of-a-green-coffee-extract-garcinia-c-ambogia-and-l-carnitine-containing-chewing-gum-on-snack-intake-and-appetite-regulation
#4
Cecilia Bobillo, Graham Finlayson, Ana Martínez, Daniela Fischman, Analisa Beneitez, Alejandro J Ferrero, Belisario E Fernández, Marcos A Mayer
INTRODUCTION: Different studies have assessed the influence of chewing gum to aid control of appetite and reduce food intake. PURPOSE: The aims of the present study were to evaluate the effects of chewing gum on satiety, food hedonics and snack intake and to explore the potential effects of the combination of Garcinia c ambogia, green coffee extract and L-carnitine on satiety, when administered in a gum format. METHODS: This was a prospective study in which 57 subjects randomly received three kinds of treatments, in a crossover design: (1) active gum; (2) placebo gum; and (3) no gum...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27869661/an-exploratory-investigation-of-endotoxin-levels-in-novice-long-distance-triathletes-and-the-effects-of-a-multi-strain-probiotic-prebiotic-antioxidant-intervention
#5
Justin D Roberts, Craig A Suckling, Georgia Y Peedle, Joseph A Murphy, Tony G Dawkins, Michael G Roberts
Gastrointestinal (GI) ischemia during exercise is associated with luminal permeability and increased systemic lipopolysaccharides (LPS). This study aimed to assess the impact of a multistrain pro/prebiotic/antioxidant intervention on endotoxin unit levels and GI permeability in recreational athletes. Thirty healthy participants (25 males, 5 females) were randomly assigned either a multistrain pro/prebiotic/antioxidant (LAB⁴ANTI; 30 billion CFU·day(-1) containing 10 billion CFU·day(-1)Lactobacillus acidophilus CUL-60 (NCIMB 30157), 10 billion CFU·day(-1)Lactobacillus acidophillus CUL-21 (NCIMB 30156), 9...
November 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27862997/identification-of-l-carnitine-and-its-impurities-in-food-supplement-formulations-by-online-column-switching-liquid-chromatography-coupled-with-linear-ion-trap-mass-spectrometry
#6
Hang Wang, Sijun Xie
The identification of impurities in l-carnitine by mass spectrometry is difficult because derivative reagents or ion pair reagents are usually used to separate and increase the retention of l-carnitine on the reversed-phase column. In this study, four impurities including 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium, 3-cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium, 3-carboxy-N,N,N-trimethylprop-2-en-1-aminium and 4-chloro-2,3,4-trihydroxy-N,N,N-trimethylbutan-1-aminium were identified in l-carnitine and its tablets by using two-dimensional column-switching high-performance liquid chromatography coupled with linear ion trap mass spectrometry...
November 15, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27855528/dietary-anthropometric-and-biochemical-factors-influencing-plasma-choline-carnitine-trimethylamine-and-trimethylamine-n-oxide-concentrations
#7
Anna M Malinowska, Artur Szwengiel, Agata Chmurzynska
The objective of the study was to evaluate the nutritional, anthropometric, and biochemical factors that influence choline, l-carnitine, trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) metabolism in elderly women. The volunteers' diet was assessed using a food frequency questionnaire. Dietary patterns were estimated using a self-established score method. Body mass index (BMI), serum glucose, total, HDL, LDL cholesterol, triacylglycerol, homocysteine (tHcy), free choline (fchol), L-carnitine, TMA, and TMAO were assessed...
November 17, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27854029/acute-administration-of-3-5-diiodo-l-thyronine-to-hypothyroid-rats-stimulates-bioenergetic-parameters-in-liver-mitochondria
#8
Alessandro Cavallo, Federica Taurino, Fabrizio Damiano, Luisa Siculella, Anna Maria Sardanelli, Antonio Gnoni
The role of 3,5-diiodo-L-thyronine (T2), initially considered only a 3,3',5-triiodo-L-thyronine (T3) catabolite, in the bioenergetic metabolism is of growing interest. In this study we investigated the acute effects (within 1 h) of T2 administration to hypothyroid rats on liver mitochondria fatty acid uptake and β-oxidation rate, mitochondrial efficiency (by measuring proton leak) and mitochondrial oxidative damage (by determining H2O2 release). Fatty acid uptake into mitochondria was measured assaying carnitine palmitoyl transferase (CPT) I and II activities, and fatty acid β-oxidation using palmitoyl-CoA as a respiratory substrate...
November 17, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27853989/proposed-recommendations-for-diagnosing-and-managing-individuals-with-glutaric-aciduria-type-i-second-revision
#9
REVIEW
Nikolas Boy, Chris Mühlhausen, Esther M Maier, Jana Heringer, Birgit Assmann, Peter Burgard, Marjorie Dixon, Sandra Fleissner, Cheryl R Greenberg, Inga Harting, Georg F Hoffmann, Daniela Karall, David M Koeller, Michael B Krawinkel, Jürgen G Okun, Thomas Opladen, Roland Posset, Katja Sahm, Johannes Zschocke, Stefan Kölker
Glutaric aciduria type I (GA-I; synonym, glutaric acidemia type I) is a rare inherited metabolic disease caused by deficiency of glutaryl-CoA dehydrogenase located in the catabolic pathways of L-lysine, L-hydroxylysine, and L-tryptophan. The enzymatic defect results in elevated concentrations of glutaric acid, 3-hydroxyglutaric acid, glutaconic acid, and glutaryl carnitine in body tissues, which can be reliably detected by gas chromatography/mass spectrometry (organic acids) and tandem mass spectrometry (acylcarnitines)...
November 16, 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27845243/in-vitro-detection-of-oxygen-and-glucose-deprivation-induced-neurodegeneration-and-pharmacological-neuroprotection-based-on-hippocampal-stratum-pyramidale-width
#10
Pınar Öz, Hale Saybaşılı
Ischemia is one of the most prominent risk factors of neurodegenerative diseases such as Alzheimer's disease. The effects of oxygen and glucose depletion in hippocampal tissue due to ischemia can be mimicked in vitro using the oxygen and glucose deprivation (OGD) model. In this study, we applied OGD on acute rat hippocampal slices in order to design an elementary yet quantitative histological technique that compares the neuroprotective effects of (l)-carnitine to known neuroprotectors, such as the N-methyl-d-aspartate (NMDA) receptor antagonist memantine and the gamma-aminobutyric acid (GABA)-B receptor agonist baclofen...
November 11, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27836788/regression-of-fibrosis-cirrhosis-by-glycine-propionyl-l-carnitine-treatment-in-d-galactosamine-induced-chronic-liver-damage
#11
Ajaz Ahmad Ganai, Ishfaq Ahmad Ganaie, Nishika Verma, Humaira Farooqi
BACKGROUND AND PURPOSE: Liver fibrosis and cirrhosis are leading causes of morbidity and mortality, with majority of preventable cases attributed to excessive alcohol consumption, viral hepatitis, or non-alcoholic fatty liver disease. We previously reported the hepatoprotective effect of Glycine propionyl-l-carnitine (GPLC) against the fulminant hepatic failure (FHF) induced by d-Galactosamine (D-GalN). In this study we evaluated the protective effect of GPLC against D-GalN induced chronic liver damage...
November 9, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27836286/acylcarnitine-profiles-reflect-metabolic-vulnerability-for-necrotizing-enterocolitis-in-newborns-born-premature
#12
Karl G Sylvester, Zachary J Kastenberg, R Larry Moss, Gregory M Enns, Tina M Cowan, Gary M Shaw, David K Stevenson, Tiffany J Sinclair, Curt Scharfe, Kelli K Ryckman, Laura L Jelliffe-Pawlowski
OBJECTIVE: To evaluate the association between newborn acylcarnitine profiles and the subsequent development of necrotizing enterocolitis (NEC) with the use of routinely collected newborn screening data in infants born preterm. STUDY DESIGN: A retrospective cohort study was conducted with the use of discharge records for infants born preterm admitted to neonatal intensive care units in California from 2005 to 2009 who had linked state newborn screening results. A model-development cohort of 94 110 preterm births from 2005 to 2008 was used to develop a risk-stratification model that was then applied to a validation cohort of 22 992 births from 2009...
November 8, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27829952/effect-of-l-carnitine-in-patients-with-liver-cirrhosis-on-energy-metabolism-using-indirect-calorimetry-a-pilot-study
#13
Yoshiyuki Sakai, Hiroki Nishikawa, Hirayuki Enomoto, Kazunori Yoh, Yoshinori Iwata, Kunihiro Hasegawa, Chikage Nakano, Kyohei Kishino, Yoshihiro Shimono, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Naoto Ikeda, Tomoyuki Takashima, Akio Ishii, Hiroko Iijima, Shuhei Nishiguchi
BACKGROUND: L-carnitine supplementation has been suggested to show several favorable effects on patients with liver cirrhosis (LC). However, there have been no reports regarding the effect of L-carnitine on energy metabolism in patients with LC using indirect calorimetry which is a well-established method for assessing the degree of liver malnutrition. We examined the effect of L-carnitine in patients with LC on energy metabolism using indirect calorimetry. METHODS: A total of 13 LC patients who are scheduled to be treated with L-carnitine (1,800 mg/day) were analyzed in this study...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27817783/-pancytopenia-and-metabolic-decompensation-in-a-neonate
#14
Jian-Qiang Tan, Da-Yu Chen, Zhen-Qin Mo, Zhe-Tao Li, Ji-Wei Huang, Ren Cai, Ti-Zhen Yan
A 9-day-old male patient was admitted to the hospital because of cough, anhelation, feeding difficulty and lethargy. The diagnostic examinations indicated pulmonary infection, severe metabolic acidosis, hyperglycemia, hyperammonemia and pancytopenia in the patient. Blood and urine screening and isovaleryl-CoA dehydrogenase (IVD) gene detection for inherited metabolic diseases were performed to clarify the etiology. Tandem mass spectrometric screening for blood showed an elevated isovalerylcarnitine (C5) level...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27807682/dilated-cardiomyopathy-as-the-only-clinical-manifestation-of-carnitine-transporter-deficiency
#15
Kyriaki Papadopoulou-Legbelou, Maria Gogou, Vaia Dokousli, Maria Eboriadou, Athanasios Evangeliou
The authors present a case of carnitine transporter deficiency, which was unmasked after an episode of respiratory distress resistant to treatment with bronchodilators. Chest radiograph showed cardiomegaly; electrocardiogram showed left ventricular hypertrophy and echocardiography revealed dilated cardiomyopathy. Heart failure therapy was initiated and metabolic screening was requested, as family history was indicative of inborn errors of metabolism. Very low levels of free carnitine and carnitine esters in blood were found and genetic testing confirmed the diagnosis of carnitine transporter deficiency...
November 3, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27790703/the-effect-of-fermented-buckwheat-on-producing-l-carnitine-and-gamma-aminobutyric-acid-gaba-enriched-designer-eggs
#16
Namhyeon Park, Tae-Kyung Lee, Thi Thanh Hanh Nguyen, Eun-Bae An, Nahyun M Kim, Young-Hyun You, Tae-Sub Park, Doman Kim
BACKGROUND: The potential of fermented buckwheat as feed additives was studied to increase L-carnitine and gamma-aminobutyric acid (GABA) in designer eggs. Buckwheat contains high levels of lysine, methionine, and glutamate, which are precursors for the synthesis of L-carnitine and GABA. Rhizopus oligosporus was used for the fermentation of buckwheat to produce L-carnitine and GABA that exert positive effects like enhanced metabolism, antioxidant activities, immunity, and blood pressure control...
October 28, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27786574/examining-the-protective-effects-of-acetyl-l-carnitine-on-cisplatin-induced-uterine-tube-toxicity
#17
Gulistan Sanem Saribas, Deniz Erdogan, Guleser Goktas, Seda Nur Akyol, Ibrahim Murat Hirfanoglu, Seren Gulsen Gurgen, Neslihan Coskun, Candan Ozogul
The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3...
October 27, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27771504/changes-in-the-levels-of-l-carnitine-acetyl-l-carnitine-and-propionyl-l-carnitine-are-involved-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-in-chicken-embryo
#18
Qixiao Jiang, Chunbo Wang, Chan Xue, Lingfang Xue, Meiting Wang, Changhao Li, Ziwen Deng, Qian Wang
Perfluorooctanoic acid (PFOA), a persistent organic pollutant, is associated with developmental toxicity. This study investigated the mechanism of PFOA-induced developmental cardiotoxicity in chicken embryo, focusing on the interactions between developmental exposure to PFOA and the levels of l-carnitine (LC), acetyl-l-carnitine (ALC) and propionyl-l-carnitine (PLC) in the heart. To evaluate the developmental cardiotoxicity, fertile chicken eggs were exposed to 0.1, 0.5, 1, 2 or 5mg/kg PFOA via air cell injection...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27769574/carnitine-supplementation-decreases-capacitation-like-changes-of-frozen-thawed-buffalo-spermatozoa
#19
Valentina Longobardi, Angela Salzano, Giuseppe Campanile, Raffaele Marrone, Francesco Palumbo, Milena Vitiello, Gianluigi Zullo, Bianca Gasparrini
The aim of this study was to evaluate the effect of carnitine supplementation of semen extender on fertility parameters of frozen-thawed buffalo sperm. Buffalo semen was cryopreserved in BioXcell containing 0 (control group), 2.5 and 7.5-mM carnitine. After thawing, viability, motility, membrane integrity and capacitation status (assessed by localization of phosphotyrosine-containing proteins and chlortetracycline, chlortetracycline assay) were evaluated. Furthermore, total antioxidant capacity, reactive oxygen species (ROS) and lipid peroxidation levels, as well as adenosine triphosphate (ATP) content and phospholipids concentration were assessed...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27758157/clinical-significance-of-different-carnitine-levels-for-improving-the-prognosis-of-patients-undergoing-hemodialysis
#20
Yu-Mei Zhang, Li Zhuo, Jing Hu, Gang Cui, Ling Zhang, Xiang-Lin Zhang, Wen-Ge Li
OBJECTIVE: To investigate plasma-free carnitine (Fc), acylcarnitine (Ac), and total carnitine (Tc) levels in patients undergoing hemodialysis (HD), and to explore their clinical significance. METHODS: A total of 20 subjects were in the normal control group and 133 patients undergoing HD were divided into medicated (received carnitine treatment) and non-medicated groups. The medicated group was further divided into three subgroups according to Fc level: Fc = 80-199, 200-299, and ≥ 300 μmol/L...
October 19, 2016: Renal Failure
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