keyword
MENU ▼
Read by QxMD icon Read
search

alcar

keyword
https://www.readbyqxmd.com/read/27683241/sex-dependent-alterations-in-mitochondrial-electron-transport-chain-proteins-following-neonatal-rat-cerebral-hypoxic-ischemia
#1
T G Demarest, R A Schuh, E L Waite, J Waddell, M C McKenna, Gary Fiskum
Males are more susceptible to brain mitochondrial bioenergetic dysfunction following neonatal cerebral hypoxic-ischemia (HI) than females. Mitochondrial biogenesis has been implicated in the cellular response to HI injury, but sex differences in biogenesis following HI have not been described. We tested the hypothesis that mitochondrial biogenesis or the expression of mitochondrial electron transport chain (ETC) proteins are differentially stimulated in the brains of 8 day old male and female rats one day following HI, and promoted by treatment with acetyl-L-carnitine (ALCAR)...
September 28, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27197831/sex-dependent-mitochondrial-respiratory-impairment-and-oxidative-stress-in-a-rat-model-of-neonatal-hypoxic-ischemic-encephalopathy
#2
Tyler G Demarest, Rosemary A Schuh, Jaylyn Waddell, Mary C McKenna, Gary Fiskum
Increased male susceptibility to long-term cognitive deficits is well described in clinical and experimental studies of neonatal hypoxic-ischemic encephalopathy. While cell death signaling pathways are known to be sexually dimorphic, a sex-dependent pathophysiological mechanism preceding the majority of secondary cell death has yet to be described. Mitochondrial dysfunction contributes to cell death following cerebral hypoxic-ischemia (HI). Several lines of evidence suggest that there are sex differences in the mitochondrial metabolism of adult mammals...
June 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27191126/acetyl-l-carnitine-targets-adenosine-triphosphate-synthase-in-protecting-zebrafish-embryos-from-toxicities-induced-by-verapamil-and-ketamine-an-in-vivo-assessment
#3
Xiaoqing Guo, Melanie Dumas, Bonnie L Robinson, Syed F Ali, Merle G Paule, Qiang Gu, Jyotshna Kanungo
Verapamil is a Ca(2)(+) channel blocker and is highly prescribed as an anti-anginal, antiarrhythmic and antihypertensive drug. Ketamine, an antagonist of the Ca(2)(+)-permeable N-methyl-d-aspartate-type glutamate receptors, is a pediatric anesthetic. Previously we have shown that acetyl l-carnitine (ALCAR) reverses ketamine-induced attenuation of heart rate and neurotoxicity in zebrafish embryos. Here, we used 48 h post-fertilization zebrafish embryos that were exposed to relevant drugs for 2 or 4 h. Heart beat and overall development were monitored in vivo...
May 18, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27079660/acetyl-l-carnitine-alcar-to-enhance-nerve-regeneration-in-carpal-tunnel-syndrome-study-protocol-for-a-randomized-placebo-controlled-trial
#4
Matthew W T Curran, Jaret Olson, Michael Morhart, Dory Sample, K Ming Chan
BACKGROUND: Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to improve nerve regeneration in those cases. Acetyl-L-carnitine (ALCAR) is involved in lipid transport, vital for mitochondrial function. Although it has been shown to be effective in various forms of neuropathies, it has not been used in traumatic or compressive peripheral nerve injury...
April 14, 2016: Trials
https://www.readbyqxmd.com/read/26902121/repositioning-of-antibiotic-levofloxacin-as-a-mitochondrial-biogenesis-inhibitor-to-target-breast-cancer
#5
Min Yu, Ruishu Li, Juan Zhang
Targeting mitochondrial biogenesis has become a potential therapeutic strategy in cancer due to their unique metabolic dependencies. In this study, we show that levofloxacin, a FDA-approved antibiotic, is an attractive candidate for breast cancer treatment. This is achieved by the inhibition of proliferation and induction of apoptosis in a panel of breast cancer cell lines while sparing normal breast cells. It also acts synergistically with conventional chemo drug in two independent in vivo breast xenograft mouse models...
March 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26898327/distinct-effects-of-ketamine-and-acetyl-l-carnitine-on-the-dopamine-system-in-zebrafish
#6
Bonnie L Robinson, Melanie Dumas, Elvis Cuevas, Qiang Gu, Merle G Paule, Syed F Ali, Jyotshna Kanungo
Ketamine, a noncompetitive N-methyl-D-aspartic acid (NMDA) receptor antagonist is commonly used as a pediatric anesthetic. We have previously shown that acetyl L-carnitine (ALCAR) prevents ketamine toxicity in zebrafish embryos. In mammals, ketamine is known to modulate the dopaminergic system. NMDA receptor antagonists are considered as promising anti-depressants, but the exact mechanism of their function is unclear. Here, we measured the levels of dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the zebrafish embryos exposed to ketamine in the presence and absence of 0...
March 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/26773361/molecular-and-biochemical-evidence-on-the-protection-of-cardiomyocytes-from-phosphine-induced-oxidative-stress-mitochondrial-dysfunction-and-apoptosis-by-acetyl-l-carnitine
#7
Amir Baghaei, Reza Solgi, Abbas Jafari, Amir Hossein Abdolghaffari, Alireza Golaghaei, Mohammad Hossein Asghari, Maryam Baeeri, Seyed Nasser Ostad, Mohammad Sharifzadeh, Mohammad Abdollahi
The aim of the present study was to investigate the efficacy of acetyl-L-carnitine (ALCAR) on pathologic changes of mitochondrial respiratory chain activity, ATP production, oxidative stress, and cellular apoptosis/necrosis induced by aluminum phosphide (AlP) poisoning. The study groups included: the Sham that received almond oil only; the AlP that received oral LD50 dose of aluminum; the AC-100, AC-200, and AC-300 which received concurrent oral LD50 dose of AlP and single 100, 200, and 300 mg/kg of ALCAR by intraperitoneal injection...
March 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26643543/neuroprotective-effects-of-acetyl-l-carnitine-against-oxygen-glucose-deprivation-induced-neural-stem-cell-death
#8
Seong Wan Bak, Hojin Choi, Hyun-Hee Park, Kyu-Yong Lee, Young Joo Lee, Moon-Young Yoon, Seong-Ho Koh
Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarction and can result in severe morbidity and mortality. In general, the neuroprotective therapies that are applied after ischemic stroke have been unsuccessful, despite many investigations. Acetyl-L-carnitine (ALCAR) plays an important role in mitochondrial metabolism and in modulating the coenzyme A (CoA)/acyl-CoA ratio. We investigated the protective effects of ALCAR against oxygen-glucose deprivation (OGD) in neural stem cells (NSCs)...
December 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26474770/quadriceps-muscle-strength-radiographic-knee-osteoarthritis-and-knee-pain-the-road-study
#9
Shigeyuki Muraki, Toru Akune, Masatoshi Teraguchi, Ryohei Kagotani, Yoshiki Asai, Munehito Yoshida, Fumiaki Tokimura, Sakae Tanaka, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Noriko Yoshimura
BACKGROUND: The objective of this study was to clarify the association of quadriceps muscle strength with knee pain using a large-scale, population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. METHODS: From the 2566 subjects at the third visit of the ROAD study, the present study analyzed 2152 subjects who completed radiographic examinations and measurements of muscle strength and mass (690 men and 1462 women; mean age, 71...
October 16, 2015: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26374445/mitochondrial-modulators-improve-lipid-composition-and-attenuate-memory-deficits-in-experimental-model-of-huntington-s-disease
#10
COMPARATIVE STUDY
Arpit Mehrotra, Abhilasha Sood, Rajat Sandhir
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of succinate dehydrogenase and induces neuropathological changes similar to those observed in Huntington's disease (HD). The objective of the present study was to investigate neuroprotective effect of mitochondrial modulators; alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALCAR) on 3-NP-induced alterations in mitochondrial lipid composition, mitochondrial structure and memory functions. Experimental model of HD was developed by administering 3-NP at sub-chronic doses, twice daily for 17 days...
December 2015: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26365406/opposing-effects-of-ketamine-and-acetyl-l-carnitine-on-the-serotonergic-system-of-zebrafish
#11
Bonnie L Robinson, Melanie Dumas, Merle G Paule, Syed F Ali, Jyotshna Kanungo
Ketamine, a pediatric anesthetic, is a noncompetitive N-methyl-D-aspartic acid (NMDA) receptor antagonist. Studies show that ketamine is neurotoxic in developing mammals and zebrafish. In both mammals and zebrafish, acetyl L-carnitine (ALCAR) has been shown to be protective against ketamine toxicity. Ketamine is known to modulate the serotonergic system in mammals. Here, we measured the levels of serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in the embryos exposed to ketamine in the presence and absence of ALCAR...
October 21, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/26316064/l-carnitine-and-pyruvate-are-prosurvival-factors-during-the-storage-of-stallion-spermatozoa-at-room-temperature
#12
Zamira Gibb, Sarah R Lambourne, Julianne Quadrelli, Nathan D Smith, Robert J Aitken
The spermatozoa of many stallions do not tolerate being cooled, restricting the commercial viability of these animals and necessitating the development of a chemically defined room temperature (RT) storage medium. This study examined the impact of two major modulators of oxidative phosphorylation, pyruvate (Pyr) and L-carnitine (L-C), on the storage of stallion spermatozoa at RT. Optimal concentrations of Pyr (10 mM) and L-C (50 mM) were first identified and these concentrations were then used to investigate the effects of these compounds on sperm functionality and oxidative stress at RT...
October 2015: Biology of Reproduction
https://www.readbyqxmd.com/read/26223802/alcar-exerts-neuroprotective-and-pro-neurogenic-effects-by-inhibition-of-glial-activation-and-oxidative-stress-via-activation-of-the-wnt-%C3%AE-catenin-signaling-in-parkinsonian-rats
#13
Sonu Singh, Akanksha Mishra, Shubha Shukla
Oxidative stress and neuroinflammation are known causative factors in progressive degeneration of dopaminergic (DAergic) neurons in Parkinson's disease (PD). Neural stem cells (NSCs) contribute in maintaining brain plasticity; therefore, survival of NSCs and neuroblasts during neurodegenerative process becomes important in replenishing the pool of mature neuronal population. Acetyl-L-carnitine (ALCAR), present in almost all body cells, increases endogenous antioxidants and regulates bioenergetics. Currently, no information is available about the putative mechanism and neuroprotective effects of ALCAR in 6-hydroxydopamine (6-OHDA)-induced rat model of PD-like phenotypes...
September 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26108035/effects-of-dietary-bacillus-licheniformis-on-growth-performance-immunological-parameters-intestinal-morphology-and-resistance-of-juvenile-nile-tilapia-oreochromis-niloticus-to-challenge-infections
#14
Biao Han, Wei-Qing Long, Ju-Yun He, Yong-Jian Liu, Yu-Qi Si, Li-Xia Tian
The effects of oral administration of Bacillus licheniformis on growth performance, immunity, intestinal morphology and disease resistance of juvenile tilapia were investigated. Six experimental diets supplemented with different concentrations of B. licheniformis (0%, 0.02%, 0.04%, 0.06%, 0.08% and 0.1% of AlCare(®), containing live germ 2 × 10(10) CFU/g) were formulated, viz. control, T1, T2, T3, T4 and T5. Each diet was randomly assigned to triplicate groups of 30 fishes (3.83 ± 0.03 g). After 10 weeks of feeding trial, weight gain (WG), final body wet weight (FBW) and specific growth rate (SGR) increased significantly in groups T2, T3, T4 and T5 compared with control and T1 (p < 0...
October 2015: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26087310/mitochondrial-biogenesis-is-required-for-the-anchorage-independent-survival-and-propagation-of-stem-like-cancer-cells
#15
Arianna De Luca, Marco Fiorillo, Maria Peiris-Pagès, Bela Ozsvari, Duncan L Smith, Rosa Sanchez-Alvarez, Ubaldo E Martinez-Outschoorn, Anna Rita Cappello, Vincenzo Pezzi, Michael P Lisanti, Federica Sotgia
Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific inhibitor of the ERRα-PGC1 signaling pathway, which governs mitochondrial biogenesis. Interestingly, our results directly demonstrate that XCT790 efficiently blocks both the survival and propagation of tumor initiating stem-like cells (TICs), using the MCF7 cell line as a model system...
June 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/26043725/acetylcarnitine-potentiates-the-anticarcinogenic-effects-of-butyrate-on-sw480-colon-cancer-cells
#16
Ihsan Elimrani, Serge Dionne, Dan Saragosti, Ijaz Qureshi, Emile Levy, Edgar Delvin, Ernest G Seidman
Butyrate is a potent anticarcinogenic compound against colon cancer cells in vitro. However, its rapid metabolism is hypothesized to limit its anticancer benefits in colonic epithelial cells. Carnitine, a potent antioxidant, is essential to fatty acid oxidation. The aims of this study were to identify a colon cancer cell line capable of transporting carnitine. We evaluated the effect of carnitine and acetylcarnitine (ALCAR) on the response of colon carcinoma cells to butyrate. We explored the mechanisms underlying the anticarcinogenic benefit...
August 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/25776802/acetyl-l-carnitine-prevents-homocysteine-induced-suppression-of-nrf2-keap1-mediated-antioxidation-in-human-lens-epithelial-cells
#17
Shui-Ping Yang, Xiu-Zhen Yang, Guo-Ping Cao
Previous studies have revealed that high levels of serum homocysteine (Hcy) are closely associated with the development of juvenile and age-related cataracts. An increased concentration of Hcy is likely to induce gene specific demethylation in DNA promoter regions. The aim of the present study was to prevent this demethylation by administering acetyl-l-carnitine (ALCAR) to human lens epithelial cells (HLECs). Different concentrations of Hcy were used to treat HLECs for 3, 6, 12 and 24 h and the findings were used to determine the optimum dose to induce endoplasmic reticulum (ER) stress...
July 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25751698/efficacy-of-carnitine-in-treatment-of-tinnitus-evidence-from-audiological-and-mri-measures-a-case-study
#18
Kamakshi V Gopal, Binu P Thomas, Deng Mao, Hanzhang Lu
BACKGROUND: Tinnitus, or ringing in the ears, is an extremely common ear disorder. However, it is a phenomenon that is very poorly understood and has limited treatment options. PURPOSE: The goals of this case study were to identify if the antioxidant acetyl-L-carnitine (ALCAR) provides relief from tinnitus, and to identify if subjective satisfaction after carnitine treatment is accompanied by changes in audiological and imaging measures. RESEARCH DESIGN: Case Study...
March 2015: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/25712252/bioanalysis-of-acetylcarnitine-in-cerebrospinal-fluid-by-hilic-mass-spectrometry
#19
Brian R Holder, Colleen A McNaney, David Luchetti, Eric Schaeffer, Dieter M Drexler
Acetyl-L-carnitine (ALCAR) is a potential biomarker for the modulation of brain neurotransmitter activity, but is also present in cerebrospinal fluid (CSF). Recent studies have utilized hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) based assays to detect and quantify ALCAR within biofluids such as urine, plasma and serum, using various sample pretreatment procedures. In order to address the need to quantify ALCAR in CSF on a high-throughput scale, a new and simple HILIC-MS/MS assay has been successfully developed and validated...
September 2015: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/25607838/sirtuin-3-dependent-mitochondrial-dynamic-improvements-protect-against-acute-kidney-injury
#20
Marina Morigi, Luca Perico, Cinzia Rota, Lorena Longaretti, Sara Conti, Daniela Rottoli, Rubina Novelli, Giuseppe Remuzzi, Ariela Benigni
Acute kidney injury (AKI) is a public health concern with an annual mortality rate that exceeds those of breast and prostate cancer, heart failure, and diabetes combined. Oxidative stress and mitochondrial damage are drivers of AKI-associated pathology; however, the pathways that mediate these events are poorly defined. Here, using a murine cisplatin-induced AKI model, we determined that both oxidative stress and mitochondrial damage are associated with reduced levels of renal sirtuin 3 (SIRT3). Treatment with the AMPK agonist AICAR or the antioxidant agent acetyl-l-carnitine (ALCAR) restored SIRT3 expression and activity, improved renal function, and decreased tubular injury in WT animals, but had no effect in Sirt3-/- mice...
February 2015: Journal of Clinical Investigation
keyword
keyword
28932
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"