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Anaphylactic shock

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https://www.readbyqxmd.com/read/29464448/development-and-validation-of-an-algorithm-to-identify-drug-induced-anaphylaxis-in-the-beijing-pharmacovigilance-database
#1
Ying Zhao, Haidong Lu, Sydney Thai, Xiaotong Li, John Hui, Huilin Tang, Suodi Zhai, Lulu Sun, Tiansheng Wang
Background Pharmacovigilance databases are utilized to identify serious adverse drug events (ADEs). In China, very few studies have evaluated the validity of using pharmacovigilance databases to identify drug-induced anaphylaxis (DIA). Objective We aimed to develop and validate an algorithm to identify DIA using the Beijing Pharmacovigilance Database (BPD). Setting ADEs from the BPD mainly spontaneously reported from 94 hospitals in Beijing, China. Method Using the diagnoses, we developed an algorithm to identify potential DIAs from the BPD between January 2004 and December 2014...
February 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29422823/anaphylaxis-in-poland-the-epidemiology-and-direct-costs
#2
Karina Jahnz-Rozyk, Filip Raciborski, Andrzej M Śliwczyński, Anna Kłak, Jarosław Pinkas
Introduction: Epidemiological data on anaphylaxis have been underestimated both in Poland and worldwide. Aim: To evaluate the prevalence of anaphylaxis in Poland, including a classification by gender, age and residential region. Material and methods: The data used in the analysis were derived from two sources, the National Health Fund records of healthcare services for 2008-2015 (official statistics) and a questionnaire-based survey conducted in 2015 on a sample of 305 allergists practicing in different regions of Poland...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29414723/are-pharmacists-good-knowledge-and-awareness-on-antibiotics-taken-for-granted-the-situation-in-albania-future-implications-across-countries
#3
Iris Hoxha, Admir Malaj, Besmira Kraja, Silvia Bino, Margaret Oluka, Vanda Marković-Peković, Brian Godman
OBJECTIVES: Irrational use of antibiotics is a major driver of antimicrobial resistance (AMR), exacerbated by dispensing of antibiotics without a prescription especially for typically viral infections. Such dispensing is common despite legislation. Pharmacists play a key role advising on medicines especially in countries where most patients seek pharmacist help as they cannot afford both physician fees and medicines. Consequently, the objective was to ascertain skills and knowledge of pharmacists regarding antibiotics when patients present to them with typically viral infections...
February 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29411561/a-case-of-intraoperative-anaphylaxis-caused-by-bovine-derived-thrombin
#4
Hye Jung Park, Kyung Soo Suk, Jung Won Park
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29406471/life-threatening-accidental-intravenous-epinephrine-overdose-in-a-12-year-old-boy
#5
Maya Caroline André, Jürg Hammer
Reports on accidental intravenous epinephrine overdose in children are extremely rare, although medication errors in the management of pediatric anaphylaxis seem to be frequent. We report a case of a 12-year-old boy presenting with a long-lasting skin rash and dyspnea who was incorrectly diagnosed with early anaphylactic shock and was treated with 10-fold the recommended dose administered by the wrong route (intravenous instead of intramuscular). He reacted with acute loss of consciousness and acute cardiorespiratory failure due to arterial hypotension, ischemic heart failure, and severe pulmonary edema...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29394784/-a-case-of-recurrent-colon-cancer-successfully-treated-with-capecitabine-plus-bevacizumab
#6
Atsushi Naito, Kohei Murata, Yoshinori Kagawa, Kenji Kawai, Takuya Sakamato, Junichi Inatome, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Toru Masuzawa, Atsushi Takeno, Chiyomi Egawa, Yutaka Takeda, Takeshi Kato, Shigeyuki Tamura
A 76-year-old woman had undergone a laparoscopic low anterior resection for rectal cancer. After 12 months, CT showed 2 tumors measuring 25mm in diameter in the pelvis and hydronephrosis. The patient was treated with CapeOX plus bevacizumab( Bmab). After 3 courses of chemotherapy, the size of the tumors was remarkably reduced. After 6 courses, the chemotherapy was withdrawn because of cystitis. Anaphylactic shock occurred after the 7th course after resumption of treatment. After 42 days, the chemotherapy(Cape plus Bmab)was resumed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394585/-a-case-of-her2-positive-breast-cancer-with-newly-diagnosed-stage-iv-that-responded-to-first-line-pertuzumab-and-trastuzumab-based-therapy
#7
Setsuko Yoshioka, Shigeyuki Hojo, Yasuhiro Toyoda, Yoshiichi Maeura
A 48-year-old woman who observed swelling and erosion in her left breast was diagnosed with locally advanced, ERnegative, HER2-positive breast cancer with de novo liver metastasis, T4cN1M1, Stage IV . She underwent primary systemic therapy with weekly paclitaxel, and pertuzumab and trastuzumab every 3 weeks. The tumor responded remarkably with 57.0% reduction in 5 weeks of treatment. Because of an anaphylactic shock to paclitaxel in day 8, exchanging to eribulin was considered less toxic than taxane, and was continued for 8 cycles until local relapse...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29382591/protein-corona-mediated-targeting-of-nano-carriers-to-b-cells-allows-redirection-of-allergic-immune-responses
#8
Limei Shen, Stefan Tenzer, Wiebke Storck, Dominika Hobernik, Verena Katharina Raker, Karl Fischer, Sandra Decker, Andrzej Dzionek, Susanne Krauthäuser, Mustafa Diken, Alexej Nikolaev, Joachim Maxeiner, Petra Schuster, Cinja Kappel, Admar Verschoor, Hansjörg Schild, Stephan Grabbe, Matthias Bros
BACKGROUND: Nanoparticle (NP) based vaccines are attractive immunotherapy tools due to their capability to co-deliver antigen and adjuvant to antigen presenting cells. Their cellular distribution and serum protein interaction ("protein corona") after systemic administration and its impact on functional properties of NP is poorly understood. OBJECTIVES: We analyzed the relevance of the protein corona on cell type-selective uptake of dextran (DEX)-coated NP and determined the outcome of vaccination with NP that codeliver antigen and adjuvant in disease models of allergy...
January 27, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29355906/antibiotic-therapy-for-preventing-infections-in-people-with-acute-stroke
#9
REVIEW
Jan-Dirk Vermeij, Willeke F Westendorp, Diederik Wj Dippel, Diederik van de Beek, Paul J Nederkoorn
BACKGROUND: Stroke is the main cause of disability in high-income countries and ranks second as a cause of death worldwide. Infections occur frequently after stroke and may adversely affect outcome. Preventive antibiotic therapy in the acute phase of stroke may reduce the incidence of infections and improve outcome. In the previous version of this Cochrane Review, published in 2012, we found that antibiotics did reduce the risk of infection but did not reduce the number of dependent or deceased patients...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29340470/traumatic-rupture-of-liver-hydatid-cysts-into-the-peritoneal-cavity-of-an-11-year-old-boy-a-case-report-from-iran
#10
Sadaf Sabzevari, Alireza Badirzadeh, Reza Shahkaram, Mohammad Seyyedin
This is the first published case report of an 11-year-old patient with a rupture of a liver hydatid cyst (HC) into the peritoneal cavity after an abdominal trauma in Iran. The disease was diagnosed using focused abdominal sonography for trauma. To date, no cases of traumatic ruptures of liver HCs in children have been reported in Iran. In the endemic regions of the world, where patients suffer from a history of trauma and constant abdominal symptoms or anaphylactic shock, early diagnosis of HC is crucial as it may disseminate to other organs...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29338163/kounis-syndrome-induced-by-oral-intake-of-diclofenac-potassium
#11
Harun Gunes, Feruza Turan Sonmez, Ayhan Saritas, Yasin Koksal
An acute coronary syndrome (ACS) occurring during the course of an allergic reaction is called Kounis syndrome (KS). The second case of KS induced by diclofenac potassium (DP) is presented in this report. A 67-year-old man was brought to our emergency department with the possible diagnosis of anaphylactic shock by the ambulance staff. It emerged that widespread erythema and pruritus developed after taking DP. Then, he lost consciousness. Diffuse urticarial lesions were detected on physical examination at the emergency department...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29303109/-protocols-related-to-food-allergies-and-intolerances-in-preschools-in-reykjavik-iceland
#12
Adalheidur Ran Thrastardottir, Frida Run Thordardottir, Johanna Torfadottir
INTRODUCTION: The aim of the study was to explore prevalence of food allergies and intolerances among children in preschools in Reykjavik, Iceland. Also, to investigate how well preschools maintain a safe environment for children with food allergies. MATERIALS AND METHODS: In 2014, a questionnaire designed specifically for this study, was sent to 65 preschools. Forty-nine participated (75%) representing a total of 4225 children. Prevalence of food allergy and intolerance was determined based on medical certificates from physi-cians delivered to the preschools...
January 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29300005/food-allergy
#13
REVIEW
Harald Renz, Katrina J Allen, Scott H Sicherer, Hugh A Sampson, Gideon Lack, Kirsten Beyer, Hans C Oettgen
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic shock. Major progress has been made in basic, translational and clinical research, leading to a better understanding of the underlying immunological mechanisms that lead to the breakdown of clinical and immunological tolerance against food antigens, which can result in either immunoglobulin E (IgE)-mediated reactions or non-IgE-mediated reactions...
January 4, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29274313/mitral-ring-extraction-due-to-nickel-allergy
#14
Carlos Dominguez-Massa, Ana M Bel-Minguez, Manuel Perez-Guillen, Alberto Berbel-Bonillo, Fernando Hornero-Sos
The incidence of allergic reactions due to mechanical prosthesis or rings is not well established. We report the case of a 56-year-old male patient who presented a persistent urticarial rash and anaphylactic shock after mitral valve repair surgery. Prick skin tests were positive for nickel. After removing the nucleus from the mitral annulus, the urticarial clinic disappeared.
December 20, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29248468/suspected-anaphylaxis-and-lack-of-clinical-protection-associated-with-envenomation-in-two-dogs-previously-vaccinated-with-crotalus-atrox-toxoid
#15
Kaelyn E Petras, Raegan J Wells, Jocelyn Pronko
OBJECTIVE: to describe the clinical presentation of two canines present in anaphylactic shock secondary to rattlesnake envenomation. In both cases, there was no previous documented previous envenomation event and the initial sensitization required for anaphylactic response is believed to be secondary to Crotalus atrox toxoid vaccine. CASE DESCRIPTION: In the first case, a 12-year-old golden retriever present for collapse, severe hematochezia, and vomiting after first time envenomation from a suspected western diamondback rattlesnake...
December 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29238519/how-to-manage-anaphylaxis-in-primary-care
#16
REVIEW
Alberto Alvarez-Perea, Luciana Kase Tanno, María L Baeza
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different combinations of symptoms and apparently mild signs and can progress to fatal anaphylactic shock unpredictably. The difficulty in recognizing anaphylaxis is due, in part, to the variability of diagnostic criteria, which in turn leads to a delay in administration of appropriate treatment, thus increasing the risk of death...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29237147/treatment-of-early-stage-extracranial-arteriovenous-malformations-with-intralesional-interstitial-bleomycin-injection-a-pilot-study
#17
Yunbo Jin, Yun Zou, Chen Hua, Hui Chen, Xi Yang, Gang Ma, Lei Chang, Yajing Qiu, Dongze Lyu, Tianyou Wang, Shih-Jen Chang, Congzhen Qiao, Chunfen Luo, Mathias Tremp, Xiaoxi Lin
Purpose To assess the efficacy and safety of intralesional interstitial bleomycin injection in the treatment of early-stage (Schobinger stage I or II) extracranial arteriovenous malformations (AVMs). Materials and Methods This prospective study involved 34 patients with early-stage AVMs, as defined by the Schobinger staging system. The patients received intralesional interstitial bleomycin injected at a maximum dose of 15 000 IU or 1000 IU per kilogram of body weight for children who weighed less than 15 kg per procedure for a total of 6 months (once every month)...
December 13, 2017: Radiology
https://www.readbyqxmd.com/read/29233461/long-term-safety-of-subcutaneous-immunotherapy-with-to-204-in-japanese-patients-with-house-dust-mite-induced-allergic-rhinitis-and-allergic-bronchial-asthma-multicenter-open-label-clinical-trial
#18
Takao Fujisawa, Terufumi Shimoda, Keisuke Masuyama, Kimihiro Okubo, Kohei Honda, Mitsuhiro Okano, Toshio Katsunuma, Atsuo Urisu, Yasuto Kondo, Hiroshi Odajima, Kazuyuki Kurihara, Makoto Nagata, Masami Taniguchi, Shoichiro Taniuchi, Satoru Doi, Tomoshige Matsumoto, Shoji Hashimoto, Akihiko Tanaka, Kensuke Natsui, Nahoko Abe, Hideki Ozaki
BACKGROUND: To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial. METHODS: Japanese patients aged 5-65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria...
December 7, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29203045/anaphylactic-shock-with-an-ultrasound-contrast-agent
#19
S Coudray, C Fabre, I Aichoun, A Perez-Martin
Echo contrast agents, such as SonoVue®, (Bracco, Milan, Italy) are often used to enhance diagnosis. Although their use is safe, some rare side effects could be severe or even fatal. We are reporting a case of severe systemic allergic reaction after infusion of SonoVue®. After a brief review of the literature, the aim of this paper is to draw attention to this risk and recall the safety instructions coming with the use of ultrasound contrast agents.
December 2017: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29201066/anaphylactic-shock-following-castor-bean-contact-a-case-report
#20
Y Coattrenec, D Jaques, P Jandus, T Harr, D Spoerl
Background: The castor bean plant, Ricinus communis , is known to have allergenic and toxic properties. Castor bean allergy has been described mainly as an occupational inhalation allergy in laboratory workers, in persons working in oil processing mills or in agricultural industry. So far, only one case of anaphylactic reaction due to castor bean sensitization confirmed by specific IgE has been described in literature. Case presentation: A 30-year-old woman presented to the emergency room with severe angioedema followed by urticaria, hypotension and tachycardia...
2017: Allergy, Asthma, and Clinical Immunology
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