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Anaphylactic shock

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https://www.readbyqxmd.com/read/29679215/diagnostic-role-of-serum-tryptase-in-anaphylactic-deaths-in-forensic-medicine-a-systematic-review-and-meta-analysis
#1
REVIEW
Kai-Jian Sun, Jie-Tao He, Hong-Yan Huang, Ye Xue, Xiao-Li Xie, Qi Wang
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock...
April 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29675258/livedo-reticularis-a-cutaneous-clue-to-an-underlying-endocrine-crisis
#2
Natasha Shrikrishnapalasuriyar, Mirena Noyvirt, Philip Evans, Bethan Gibson, Elin Foden, Atul Kalhan
A 54-year-old woman was admitted to hospital with a presumed allergic reaction to a single dose of amoxicillin given for a suspected upper respiratory tract infection. She complained of chest tightness although there was no wheeze or stridor. On examination, she was pyrexial, tachycardic, hypertensive and had a diffuse mottled rash on her lower limbs. Her initial investigations showed raised inflammatory markers. She was treated in the intensive care for a presumed anaphylactic reaction with an underlying sepsis...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29672323/anaphylactic-reactions-to-native-and-light-exposed-sugammadex-suggested-by-basophil-activation-test-a-report-of-2-cases
#3
Takashige Yamada, Takeshi Suzuki, Reiko Murase, Hiromasa Nagata, Shizuko Kosugi
We describe 2 patients who developed anaphylactic shock after sugammadex administration during anesthesia. Both had no history of prior sugammadex administration. The serum tryptase concentrations were elevated after the allergic reaction. Basophil activation testing 1 month after the events was positive for sugammadex in 1 patient, and negative in the other. However, it was positive for light-exposed sugammadex solution in both patients, suggesting a possible allergic reaction to a denatured compound of sugammadex generated by light exposure of the sugammadex solution...
April 17, 2018: A&A practice
https://www.readbyqxmd.com/read/29671689/two-cases-of-anaphylactic-shock-by-methylprednisolone-in-neuromyelitis-optica
#4
Keita Takahashi, Tetsuya Asano, Yuichi Higashiyama, Shigeru Koyano, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka
Steroid pulse therapy with methylprednisolone (mPSL) succinate ester is the most common treatment for neuromyelitis optica (NMO); no cases of anaphylaxis have been reported to date. Here, we report two cases of anaphylactic shock induced by mPSL pulse therapy in patients with NMO and concurrent systemic lupus erythematosus. Both patients had received several courses of mPSL pulse therapy without any problems previously. Repeated mPSL pulse therapy and comorbid humoral autoimmune disease might increase the risk of anaphylaxis...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29671675/clinical-commentary-on-two-cases-of-anaphylactic-shock-by-methylprednisolone-in-neuromyelitis-optica
#5
Breogán Rodríguez-Acevedo, Jordi Río
No abstract text is available yet for this article.
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29669068/adverse-reactions-after-intravenous-iron-infusion-among-inflammatory-bowel-disease-patients-in-the-united-states-2010-2014
#6
Eboselume Akhuemonkhan, Alyssa Parian, Kathryn A Carson, Susan Hutfless
Background: Anemia is a frequent complication of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD). Intravenous (IV) iron is recommended as the initial therapy for patients with clinically active IBD, severe anemia, and intolerance to oral iron. IV iron is associated with serious adverse effects including a black box warning for anaphylaxis with iron dextran and ferumoxytol. We aimed to examine the occurrence of adverse reactions including anaphylaxis after IV iron infusions in a large database of US IBD patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29655675/eupatilin-suppresses-the-allergic-inflammatory-response-in-vitro-and-in-vivo
#7
Eun-Hye Song, Kyung-Sook Chung, Yun-Mi Kang, Jong-Hyun Lee, Minho Lee, Hyo-Jin An
INTRODUCTION: Eupatilin, a pharmacologically active ingredient found in Artemisia asiatica, has been reported to have anti-oxidative, anti-inflammatory, and anti-apoptotic activities. However, molecular mechanisms underlying its anti-allergic properties are not yet clear. In this study, we investigated the effects of eupatilin on allergic inflammation in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells and a compound 48/80-induced anaphylactic shock model...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29650839/-a-case-of-splenic-metastasis-from-serous-surface-papillary-carcinoma-of-the-peritoneum-treated-by-laparoscopic-splenectomy
#8
Yongkook Kim, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Junji Kawada, Miho Okano, Masaki Okuyama, Takeshi Yokoi, Masaru Yamasaki, Toshimasa Tsujinaka
A 50-year-old woman with abdominal fullness, lower abdominal pain, elevated serum CA125, and ascites, underwent neoadjuvant chemotherapy with 6 courses of PTX/CBDCA followed by total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and intrapelvic peritoneal stripping based on a diagnosis of serous surface papillary carcinoma(SSPC) of the peritoneum. Complete response(CR)was shown after adjuvant chemotherapy with 3 courses of the same regimen. After 6 months, serum CA125 level re-increased and abdominal CT showed small low density areas in the patient's spleen and the perisplenic fat tissue...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644714/design-synthesis-and-biological-evaluation-of-2-substituted-2-3-4-9-tetrahydrospiro-%C3%AE-carboline-3-carboxylic-acid-derivatives-as-first-in-class-mast-cell-stabilizers
#9
Jatinder Singh, Ramanpreet Shah, Dhandeep Singh, Amteshwar S Jaggi, Nirmal Singh
Mast cell degranulation plays a momentous role in myriad diseases like asthma, eczema, allergic rhinitis, and conjunctivitis as well as anaphylactic shock; hence, there is an unmet need for developing new mast cells stabilizers. The reported mast cell stabilizers have a heterocyclic moiety and an acidic group. Furthermore, the role of tryptophan in suppression of mast cell activation is established. Hence, we prepared constrained analogs of tryptophan, which are derivatives of 2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid, and evaluated them for ex vivo inhibition of compound 48/80-induced mast degranulation activity...
April 12, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29599628/analysis-of-acute-transfusion-reactions-and-their-occurrence-times
#10
Yuki Hatayama, Satoko Matsumoto, Eiko Hamada, Nao Kojima, Ayako Hara, Norihiko Hino, Toru Motokura
Acute transfusion reactions (ATRs) are significantly relevant to the morbidity and mortality of patients. ATRs are mostly not severe and rarely cause severe conditions, including anaphylactic shock. The aim of this study was to clarify the frequency of ATRs and the time of event occurrence. A total of 18,745 transfusions were administered to 11,718 patients during a 3-year period. Adverse reactions including at least one sign or symptom were collected through a report system in 143 of 2,478 (5.7%) platelet concentrate transfusions, 105 of 6,629 (1...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29572099/a-ten-year-analysis-of-the-reasons-for-death-following-ambulatory-surgery-nine-closed-claims-declared-to-sham-insurance
#11
A Theissen, F Fuz, M Bouregba, M Autran, M Beaussier
INTRODUCTION: The constant development of ambulatory surgery (AS) raises the problem of monitoring patients after discharge and the risk of death in the case of delays in the management of a serious complication. PATIENTS AND METHODS: The aim of this retrospective study was to describe the deaths observed within the 30-day period following AS declared to the SHAM insurance (Société Hospitalière d'Assurance Mutuelle) over the last 10 years. RESULTS: During the study period 33,962 claims were surgery-related and 11 were for deaths after AS...
March 20, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29532572/drug-safety-and-big-clinical-data-detection-of-drug-induced-anaphylactic-shock-events
#12
Guillaume Bouzillé, Marie-Noëlle Osmont, Louise Triquet, Natalia Grabar, Cécile Rochefort-Morel, Emmanuel Chazard, Elisabeth Polard, Marc Cuggia
RATIONALE, AIMS, AND OBJECTIVES: The spontaneous reporting system currently used in pharmacovigilance is not sufficiently exhaustive to detect all adverse drug reactions (ADRs). With the widespread use of electronic health records, biomedical data collected during the clinical care process can be reused and analysed to better detect ADRs. The aim of this study was to assess whether querying a Clinical Data Warehouse (CDW) could increase the detection of drug-induced anaphylaxis. METHODS: All known cases of drug-induced anaphylaxis that occurred or required hospitalization at Rennes Academic Hospital in 2011 (n = 19) were retrieved from the French pharmacovigilance database, which contains all reported ADR events...
March 13, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29528930/anaphylactic-shock-after-intravenous-fluorescein-administration-for-intraoperative-cystoscopy
#13
Toy Lee, Derrick Sanderson, Paula Doyle, Gunhilde Buchsbaum
BACKGROUND: Rates of administration of intravenous sodium fluorescein during cystoscopy have increased since indigotindisulfonate sodium was removed from the market in 2014. Although sodium fluorescein has been extensively evaluated and found to be safe, side effects including anaphylaxis have been observed, with an incidence between 0.05% and 1.0%. CASE: We present a case of anaphylactic shock after administration of intravenous sodium fluorescein for the assessment of ureteral efflux in a patient with a history of frequent severe allergic reactions undergoing urethral lysis and cystoscopy for urinary retention...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29510266/what-about-sentinel-lymph-node-biopsy-for-early-breast-cancer-during-pregnancy
#14
V Balaya, H Bonsang-Kitzis, C Ngo, M Delomenie, M Gosset, M Mimouni, C Nos, P M David, A S Bats, F Lecuru
Pregnancy-associated breast cancer is rare, but this clinical situation arises in 1/10,000-1/3000 pregnancies. In patients presenting an early-stage breast tumor devoid of clinically pathological lymph node, sentinel lymph node (SLN) biopsy has not yet been validated as a routine procedure for pregnant women due to the lack of data in the literature. The blue dye injection is not recommended because of 2% theoretical risk of anaphylactic shock. Several studies have shown that Tc99m injection at conventional dose between 12...
March 3, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29509525/a-case-of-rocuronium-induced-anaphylactic-shock-in-an-asthmatic-child
#15
Ryuichiro Tanoue, Yusuke Takei, Yu Hayashida, Hideki Harada
We experienced a case of anaphylactic shock in a young asthmatic child immediately after administering rocuronium during the induction of anesthesia. Because urticaria did not develop immediately after ventilation difficulty, we diagnosed and responded to asthma, rather than to anaphylactic shock. Correct and rapid response to anaphylactic is extremely important.
2018: Anesthesia Progress
https://www.readbyqxmd.com/read/29492269/mammalian-meat-allergy-following-a-tick-bite-a-case-report
#16
W Landon Jackson
The alpha-gal allergy is an emerging IgE-mediated reaction against the galactose-alpha-1,3-galactose carbohydrate found in mammalian meats. Patients with this condition will develop anaphylactic symptoms 3-6 h after the ingestion of mammalian meat food products such as beef, pork or lamb. The prevalence of this allergy is drastically increasing and severe reactions including anaphylactic shock have been reported, yet many patients experience symptoms for years before a diagnosis is made. We describe the presentation, diagnosis and management of a patient with the alpha-gal allergy in attempt to improve early recognition and management of patients with this condition...
February 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29486781/vasoplegia-treatments-the-past-the-present-and-the-future
#17
REVIEW
Bruno Levy, Caroline Fritz, Elsa Tahon, Audrey Jacquot, Thomas Auchet, Antoine Kimmoun
Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular smooth muscle cells such as G protein-coupled receptor desensitization (adrenoceptors, vasopressin 1 receptors, angiotensin type 1 receptors), alteration of second messenger pathways, critical illness-related corticosteroid insufficiency, and increased production of nitric oxide. This review, based on a critical appraisal of the literature, discusses the main current treatments and future approaches...
February 27, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29464448/development-and-validation-of-an-algorithm-to-identify-drug-induced-anaphylaxis-in-the-beijing-pharmacovigilance-database
#18
Ying Zhao, Haidong Lu, Sydney Thai, Xiaotong Li, John Hui, Huilin Tang, Suodi Zhai, Lulu Sun, Tiansheng Wang
Background Pharmacovigilance databases are utilized to identify serious adverse drug events (ADEs). In China, very few studies have evaluated the validity of using pharmacovigilance databases to identify drug-induced anaphylaxis (DIA). Objective We aimed to develop and validate an algorithm to identify DIA using the Beijing Pharmacovigilance Database (BPD). Setting ADEs from the BPD mainly spontaneously reported from 94 hospitals in Beijing, China. Method Using the diagnoses, we developed an algorithm to identify potential DIAs from the BPD between January 2004 and December 2014...
February 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29422823/anaphylaxis-in-poland-the-epidemiology-and-direct-costs
#19
Karina Jahnz-Rozyk, Filip Raciborski, Andrzej M Śliwczyński, Anna Kłak, Jarosław Pinkas
Introduction: Epidemiological data on anaphylaxis have been underestimated both in Poland and worldwide. Aim: To evaluate the prevalence of anaphylaxis in Poland, including a classification by gender, age and residential region. Material and methods: The data used in the analysis were derived from two sources, the National Health Fund records of healthcare services for 2008-2015 (official statistics) and a questionnaire-based survey conducted in 2015 on a sample of 305 allergists practicing in different regions of Poland...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29414723/are-pharmacists-good-knowledge-and-awareness-on-antibiotics-taken-for-granted-the-situation-in-albania-future-implications-across-countries
#20
Iris Hoxha, Admir Malaj, Besmira Kraja, Silvia Bino, Margaret Oluka, Vanda Marković-Peković, Brian Godman
OBJECTIVES: Irrational use of antibiotics is a major driver of antimicrobial resistance (AMR), exacerbated by dispensing of antibiotics without a prescription especially for typically viral infections. Such dispensing is common despite legislation. Pharmacists play a key role advising on medicines especially in countries where most patients seek pharmacist help as they cannot afford both physician fees and medicines. Consequently, the objective was to ascertain skills and knowledge of pharmacists regarding antibiotics when patients present to them with typically viral infections...
February 4, 2018: Journal of Global Antimicrobial Resistance
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