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Thyroid stimulating hormone

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https://www.readbyqxmd.com/read/29650270/radioiodine-refractory-differentiated-thyroid-cancer
#1
REVIEW
Yuchen Jin, Douglas Van Nostrand, Lingxiao Cheng, Min Liu, Libo Chen
Differentiated thyroid cancer (DTC) is usually curable with surgery, radioactive iodine (RAI), and thyroid-stimulating hormone (TSH) suppression. However, local recurrence and/or distant metastases occur in approximately 15% of cases during follow-up, and nearly two-thirds of these patients will become RAI-refractory (RR-DTC) with a poor prognosis. This review focuses on the most challenging and rapidly evolving aspects of RR-DTC, and we discuss the considerable improvement in more accurately defining RR-DTC, more effective therapeutic strategies, and describe the diagnosis, pathogenesis, and future prospects of RR-DTC...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29650181/relationship-between-levels-of-thyroid-stimulating-hormone-age-and-gender-with-symptoms-of-depression-among-patients-with-thyroid-disorders-as-measured-by-the-depression-anxiety-stress-scale-21-dass-21
#2
Sanisah Saidi, Siti Nur Iliani Jaafar, Azlina Daud, Ramli Musa, Nik Noor Fatnoon Nik Ahmad
OBJECTIVE: The aim of this study was to investigate the correlation between levels of depression symptoms and age, thyroid-stimulating hormone levels, and stressful life events of the participants. METHOD: Patients above 18 years old, with any thyroid disorders, and without psychiatric disorders were included in this study. All participants completed the Depression Anxiety Stress Scale 21 (DASS-21). The depression symptom score was calculated and interpreted as follows: less than 9: no depression; between 10 and 13: mild depression; between 14 and 20: moderate depression; between 21 and 27: severe depression, and more than 28: extremely severe depression...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29649216/serum-microrna-profiles-in-athyroid-patients-on-and-off-levothyroxine-therapy
#3
Elske T Massolt, Layal Chaker, Theo J Visser, Ad J M Gillis, Lambert C J Dorssers, Carolien M Beukhof, Boen L R Kam, Gaston J Franssen, Giulia Brigante, Tessa M van Ginhoven, W Edward Visser, Leendert H J Looijenga, Robin P Peeters
BACKGROUND: Levothyroxine replacement treatment in hypothyroidism is unable to restore physiological thyroxine and triiodothyronine concentrations in serum and tissues completely. Normal serum thyroid stimulating hormone (TSH) concentrations reflect only pituitary euthyroidism and, therefore, novel biomarkers representing tissue-specific thyroid state are needed. MicroRNAs (miRNAs), small non-coding regulatory RNAs, exhibit tissue-specific expression patterns and can be detectable in serum...
2018: PloS One
https://www.readbyqxmd.com/read/29649016/thyroid-cancer-management-from-a-suspicious-nodule-to-targeted-therapy
#4
Francesco Perri, Antonio Giordano, Salvatore Pisconti, Franco Ionna, Maria G Chiofalo, Francesco Longo, Davide Leopardo, Giuseppina Della Vittoria Scarpati, Luciano Pezzullo
Thyroid nodules are very common, and their frequency is four to five times higher in women than in men. Most of them are benign, with only a very little percentage revealing a malignant neoplasm. About 50% of thyroid nodules are detected by self-palpation of neck, whereas the other 50% are diagnosed by neck ultrasonography and following fine-needle aspiration. Management of thyroid nodules is very difficult, because benign nodules are prevalent, whereas thyroid carcinoma is uncommon, representing only 1% of all malignancies...
April 11, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29648626/regulation-of-intracellular-triiodothyronine-is-essential-for-optimal-macrophage-function
#5
Anne H van der Spek, Olga V Surovtseva, Kin Ki Jim, Adri van Oudenaren, Matthijs C Brouwer, Christina M J E Vandenbroucke-Grauls, Pieter J M Leenen, Diederik van de Beek, Arturo Hernandez, Eric Fliers, Anita Boelen
Innate immune cells, including macrophages, have recently been identified as novel target cells for thyroid hormone. We hypothesized that optimal intracellular concentrations of the active thyroid hormone triiodothyronine (T3) are essential for pro-inflammatory macrophage function. T3 is generated intracellularly by type 2 deiodinase (D2) and acts via the nuclear thyroid hormone receptor (TR). In zebrafish embryos, D2 knockdown increased mortality during pneumococcal meningitis. Primary murine D2KO macrophages exhibited impaired phagocytosis and partially reduced cytokine response to stimulation with bacterial endotoxin...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29642533/rhabdomyolysis-in-a-young-girl-with-van-wyk-grumbach-syndrome-due-to-severe-hashimoto-thyroiditis
#6
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Autoimmune hypothyroidism (Hashimoto thyroiditis; HT) is the most common postnatal thyroid disease. Clinical manifestations of HT vary according to disease severity. Due to the pleiotropic effects of thyroid hormone, less common signs and symptoms of HT can occur, leading to a delay in diagnosis. Case presentation: A 9-year-old girl of Indian origin was admitted for a one-week history of widespread myalgia, fatigue, muscle weakness, difficulty walking, and a significant increase in weight (approximately 2 kg) without any changes in daily habits...
April 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29642517/asymptomatic-effect-of-occupational-radiation-exposure-on-thyroid-gland-hormones-and-thyroid-gland-ultrasonographic-abnormalities
#7
Khaled Alawneh, Musa Alshehabat, Haytham Al-Ewaidat, Liqaa Raffee, Duaa Forihat, Yousef Khader
Data evaluating the effect of asymptomatic effects of radiation on thyroid hormone panels and ultrasonographic abnormalities among radiology technologists are scarce. This study aimed to determine the asymptomatic effect of radiation in a total of 39 male and 11 female exposed radiology technologists working in radiology departments, and a total of 34 male and 16 female age-matched controls working in other departments in the same hospital. The level of triiodothyronine (T₃), thyroxine (T₄) and thyroid-stimulating hormone (TSH) were evaluated using Enzyme Linked Immunosorbent Assay (ELISA)...
April 9, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29628400/-prevalence-and-prognostic-value-of-non-thyroidal-illness-syndrome-among-critically-ill-children
#8
Sohair Sayed Abu El-Ella, Muhammad Said El-Mekkawy, Mohamed Abdelrahman El-Dihemey
INTRODUCTION: Alterations in thyroid hormones during critical illness, known as non-thyroidal illness syndrome (NTIS), were suggested to have a prognostic value. However, pediatric data is limited. The aim of this study was to assess prevalence and prognostic value of NTIS among critically ill children. MATERIALS AND METHODS: A prospective observational study conducted on 70 critically ill children admitted into pediatric intensive care unit (PICU). Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were measured within 24hours of PICU admission...
April 5, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29628021/regulation-by-3-5-3-tri-iodothyronine-and-fsh-of-cytochrome-p450-family-19-cyp19-expression-in-mouse-granulosa-cells
#9
Juan Liu, Yingying Han, Ye Tian, Xuechun Weng, Xusong Hu, Wenbo Liu, Dai Heng, Kaili Xu, Yanzhou Yang, Cheng Zhang
Cytochrome P450 family 19 (CYP19) plays an important role in follicular development, which is regulated by FSH. Although 3,5,3'-tri-iodothyronine (T3) combines with FSH to induce preantral follicle growth and granulosa cell development, the mechanism involved remains unclear. The aim of the present study was to determine the cellular and molecular mechanisms by which thyroid hormone (TH) and FSH regulate CYP19 expression and sterol biosynthesis during preantral follicle growth. Mice were injected subcutaneously (s...
April 9, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29624097/positive-thyrotropin-receptor-antibodies-in-patients-with-transient-thyrotoxicosis
#10
Trevor E Angell, Olivia Van Benschoten, David A Cohen, Andrea V Haas, Erik K Alexander, Ellen Marqusee
OBJECTIVE: Thyrotropin (TSH) receptor antibody (TRAb) testing is considered accurate for the diagnosis of Graves' disease (GD), and had been identified rarely in thyrotoxic patients without GD. We describe four patients with transient thyrotoxicosis and positive TRAb to highlight this clinical possibility. METHODS: Patient demographics, symptoms, laboratory findings, and time to resolution of thyrotoxicosis are summarized. TRAb testing was performed by either a third-generation thyrotropin binding inhibitory immunoglobulin competitive binding assay (TBII) or a thyroid stimulating antibody bioassay (TSI) from either Mayo Clinic Laboratory or Quest Diagnostics...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29624094/percutaneous-ethanol-injection-for-benign-cystic-and-mixed-thyroid-nodules
#11
A Ozderya, K Aydin, N Gokkaya, S Temizkan
BACKGROUND/AIM: We aimed to determine the effect of percutaneous ethanol injection (PEI) on volume of cystic and mixed thyroid nodules, thyroid function tests (TFTs), antibody titers and cytological changes for 1 year. METHODS: Fifty-five nodules of 53 patients with cystic and mixed properties treated with PEI were included. Nodule volumes, TFTs, thyroid autoantibodies were analyzed at baseline, 6th and 12th months. Fine needle aspiration biopsy (FNAB) was performed to PEI applied nodules in the 12th month...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623823/low-25-hydroxyvitamin-d-levels-are-independently-associated-with-autoimmune-thyroiditis-in-a-cohort-of-apparently-healthy-overweight-and-obese-subjects
#12
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29623516/sensitivity-of-supplementation-of-thyroid-hormone-on-treatment-of-idiopathic-short-stature-children-during-therapy-with-recombinant-human-growth-hormone
#13
Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng
This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5-3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo...
April 6, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29623208/a-rare-challenging-case-of-co-existent-craniopharyngioma-acromegaly-and-squamous-cell-lung-cancer
#14
Athanasios Fountas, Shu Teng Chai, John Ayuk, Neil Gittoes, Swarupsinh Chavda, Niki Karavitaki
Co-existence of craniopharyngioma and acromegaly has been very rarely reported. A 65-year-old man presented with visual deterioration, fatigue and frontal headaches. Magnetic resonance imaging revealed a suprasellar heterogeneous, mainly cystic, 1.9 × 2 × 1.9 cm mass compressing the optic chiasm and expanding to the third ventricle; the findings were consistent with a craniopharyngioma. Pituitary hormone profile showed hypogonadotropic hypogonadism, mildly elevated prolactin, increased insulin-like growth factor 1 (IGF-1) and normal thyroid function and cortisol reserve...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29620956/clinical-hormonal-and-metabolic-parameters-in-women-with-subclinical-hypothyroidism-and-polycystic-ovary-syndrome-a-cross-sectional-study
#15
Mohamed A Bedaiwy, Mohamed Y Abdel-Rahman, Justin Tan, Faten F AbdelHafez, Amr O Abdelkareem, Drisana Henry, Sarka Lisonkova, William W Hurd, James H Liu
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS. METHODS: This is a cross-sectional study conducted in a tertiary care clinic at Cleveland, Ohio, USA...
April 5, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29617370/metabolic-and-hormonal-adaptation-in-bubalus-bubalis-around-calving-and-early-lactation
#16
Enrico Fiore, Francesca Arfuso, Matteo Gianesella, Domenico Vecchio, Massimo Morgante, Elisa Mazzotta, Tamara Badon, Pasquale Rossi, Silvia Bedin, Giuseppe Piccione
Pregnancy and lactation are physiological periods that result in an increased metabolic demand that, if not satisfied, could provoke a threat to homeostasis. In this study changes in the values of Non-Esterified Fatty Acids (NEFA) and β-hydroxybutyrate (BHB), glucose, insulin, thyroid hormones, milk composition and yield were investigated in buffaloes during the late pregnancy and early lactation. From a total of 50 buffaloes, blood samples were collected -7±5 days before expected calving; +7±5; +30±5 and +50±5 days post-partum; milk samples were collected at the same post-partum time points...
2018: PloS One
https://www.readbyqxmd.com/read/29614339/key-gene-co-expression-modules-and-functional-pathways-involved-in-the-pathogenesis-of-graves-disease
#17
Xiaoqing Shao, Bin Wang, Kaida Mu, Ling Li, Qian Li, Weiwei He, Qiuming Yao, Xi Jia, Jin-An Zhang
Graves' disease (GD) is a common autoimmune thyroid disease characterized by positive thyroid stimulating hormone receptor antibody. To better understand its molecular pathogenesis, we adopted the weighted gene co-expression network analysis to reveal co-expression modules of key genes involved in the pathogenesis of GD, protein-protein interaction network analysis to identify the hub genes related to GD development and functional analyses to explore their possible functions. Our results showed that 1) a total of 2667 differentially expressed genes in our microarray study and 16 different gene co-expression modules were associated with GD, and 2) the most significant module was associated with the percentage of macrophages, T follicular helper cells and CD4+ memory T cells and mainly enriched in immune regulation and immune response...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29609448/the-relationship-between-subclinical-hypothyroidism-and-serum-levels-of-uric-acid-and-creatinine-in-children-aged-2-14-years
#18
Saba Sayari, Ziba Molaei, Zohre Torabi
PURPOSE: Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29608782/one-year-effect-of-the-medicare-annual-wellness-visit-on-detection-of-cognitive-impairment-a-cohort-study
#19
Nicole R Fowler, Noll L Campbell, Gerhardt M Pohl, Leanne M Munsie, Noam Y Kirson, Urvi Desai, Erich J Trieschman, Mark K Meiselbach, J Scott Andrews, Malaz A Boustani
OBJECTIVES: To examine the effect of the Medicare Annual Wellness Visit (AWV) on the detection of cognitive impairment and on follow-up cognitive care for older adults. DESIGN: Retrospective matched-cohort study. SETTING: United States. PARTICIPANTS: A 5% random sample of fee-for-service Medicare beneficiaries continuously enrolled for 12 months before and after an index ambulatory visit occurring from 2011 to 2013 with no claims evidence of cognitive impairment before index...
April 2, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29606869/propylthiouracil-coated-biodegradable-polymer-inhibited-neointimal-formation-and-enhanced-re-endothelialization-after-vascular-injury
#20
Shang-Hung Chang, Cheng-Hung Lee, Yung-Hsin Yeh, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Wei-Jan Chen
Background: The drug-eluting stent is a standard approach for the treatment of coronary artery disease. Propylthiouracil (PTU), an antithyroid drug, has been proven to suppress neointimal formation after balloon injury. Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. Electrospinning was used to fabricate hybrid stents and generate PTU-loaded nanofibers...
2018: International Journal of Nanomedicine
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