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POCD in children

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https://www.readbyqxmd.com/read/27057869/short-term-changes-in-postoperative-cognitive-function-in-children-aged-5-to-12-years-undergoing-general-anesthesia-a-cohort-study
#1
Cindy S T Aun, Catherine McBride, Anna Lee, Angel S C Lau, Raymond C K Chung, Chung Kwong Yeung, Kelly Y C Lai, Tony Gin
Due to the neurotoxicity effects of general anesthesia (GA) and sedatives found in animal studies, there is a general recommendation to avoid nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age. The aim of this study was to determine the incidence of anesthesia-related postoperative cognitive dysfunction (POCD) on the first day (Day 1) and at 6 weeks after elective noncardiac surgery in school-age children.This was a prospective cohort study of 118 children undergoing GA and 126 age-matched controls of school children aged 5 to 12 years...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26871797/effects-of-heart-bypass-surgery-on-plasma-a%C3%AE-40-and-a%C3%AE-42-levels-in-infants-and-young-children
#2
Yaoqin Hu, Shanshan Shi, Xiwang Liu, Zhiyong Hu, Wenfang Huang, Dongpi Wang, Jianguo Xu, Baoli Cheng, Xiangming Fang, Qiang Shu
Accumulation of β-amyloid (Aβ) plaques is a pathological hallmark of Alzheimer disease. Aβ levels in animals and adults were reported to be associated with postoperative cognitive dysfunction (POCD). Our goal was to determine the plasma levels of Aβ in infants and young children after cardiac surgery with cardiopulmonary bypass (CPB).Forty-two infants and young children aged from 1 to 35 months undergoing cardiac surgery with general anesthetics were prospectively enrolled from January to June 2014 at a tertiary medical center...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/24330482/children-s-cognitive-recovery-after-day-case-general-anesthesia-a-randomized-trial-of-propofol-or-isoflurane-for-dental-procedures
#3
RANDOMIZED CONTROLLED TRIAL
Keith Millar, Adrian W Bowman, Deirdre Burns, Paul McLaughlin, Tony Moores, Neil S Morton, Toni Musiello, Ewan Wallace, Alyson Wray, Richard R Welbury
BACKGROUND: Postoperative cognitive dysfunction (POCD) is well established in adults but has been underinvestigated in children. As day-case procedures are increasingly common, it is important to establish whether children suffer significant POCD. Pediatric POCD has been associated with several intravenous and inhalation anesthetics, but isoflurane has not been studied. As evidence indicates superior recovery after propofol, the study compared POCD after propofol or isoflurane anesthesia...
February 2014: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/22993919/-correction-of-early-cognitive-disorders-in-school-age-children-operated-under-total-intravenous-anaesthesia
#4
RANDOMIZED CONTROLLED TRIAL
A M Ovezov, M A Lobov, M V Panteleeva, A V Lugovoĭ, P S Miatchin, I E Gus'kov
UNLABELLED: The aim of the study was to assess the possibility and effectiveness of hopaten acid use for early postoperative cognitive dysfunction correction in children of school age. MATERIALS AND METHODS: In compliance with inclusion and exclusion criteria, totally 40 children of school age (7-16 years old, ASA status I-II) with surgical pathology: (varicocele, cryptorchidism, inguinal hernia) were included A comperative assessment of neuropsychic status during pre - and postoperative are period in children, operated under propofol-fentanyl total intravenous anesthesia (TIVA) was conducted All patients were randomized to the control (without cepebroprotection 1st group, 20 children) and experimental (using cepebroprotection with hopaten acid within 1 month after the operation, 2nd group, 20 children) groups...
May 2012: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/16803914/evidence-based-clinical-update-general-anesthesia-and-the-risk-of-delirium-and-postoperative-cognitive-dysfunction
#5
REVIEW
Gregory L Bryson, Anna Wyand
PURPOSE: The purpose of this structured, evidence-based, clinical update was to identify the best evidence comparing general and regional anesthesia and their influence on delirium or cognitive dysfunction (POCD) in the postoperative period. SOURCE: In June 2005 a structured search of MEDLINE from 1966 to present using OVID software was undertaken. Medical subject headings and textwords describing both delirium and POCD were employed. OVID's Therapy (sensitivity) algorithm was used to maximize the detection of randomized trials...
July 2006: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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