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Osteoporosis older adults

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https://www.readbyqxmd.com/read/29677308/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#1
Leila C Kahwati, Rachel Palmieri Weber, Huiling Pan, Margaret Gourlay, Erin LeBlanc, Manny Coker-Schwimmer, Meera Viswanathan
Importance: Osteoporotic fractures result in significant morbidity and mortality. Objective: To update the evidence for benefits and harms of vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults to inform the US Preventive Services Task Force. Data Sources: PubMed, EMBASE, Cochrane Library, and trial registries through March 21, 2017; references; and experts. Surveillance continued through February 28, 2018...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29658144/bone-fragility-in-turner-syndrome-fracture-prevalence-and-risk-factors-determined-by-a-national-patient-survey
#2
Halley Wasserman, Philippe F Backeljauw, Jane C Khoury, Heidi J Kalkwarf, Catherine M Gordon
OBJECTIVE: Osteoporosis is considered a comorbidity of adult women with Turner Syndrome (TS). Limited data are available on fracture prevalence in girls and women with this diagnosis. We aimed to determine the prevalence of fractures in individuals with TS in the United States and identify risk factors for fracture. DESIGN: Girls and women with TS were invited to participate in an anonymous, self-report, national survey from November 2016 to March 2017. Non-TS controls were obtained through direct contacts of TS participants...
April 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29624982/clinical-interventions-in-osteosarcopenic-obesity-nutrition-physical-and-psychological-activity
#3
Ana Isabel García-González, Zoraida Axtle-Serrano, Miriam López-Teros, Claudia Szlejf, Adrián Martínez-Ruiz, Oscar Rosas-Carrasco
Osteosarcopenic obesity (OSO) is a condition associated with adverse outcomes in older adults. Since it is a condition which includes three tissues (obesity, sarcopenia and osteopenia/osteoporosis), it requires simultaneous and multidisciplinary clinical interventions to revert it. Until this moment, there have been published review articles only focused on nutrition or physical activity. However, we believe that assembling the existing evidence on potential treatments (nutritional intervention with micro- and macronutrients), physical activity, farmacological treatment for osteopenia/osteoporosis, possible farmacological treatment for sarcopenia, and, finally, psychological interventions focused on the treatment of psychiatric comorbidities (such as anxiety or depression) will help healthcare providers to improve the body composition of older adults...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29616561/denosumab-a-unique-perspective-on-adherence-and-cost-effectiveness-compared-with-oral-bisphosphonates-in-osteoporosis-patients
#4
Paige Morizio, Jena I Burkhart, Sachiko Ozawa
OBJECTIVE: To assess the cost-effectiveness as well as adherence and patient preference for denosumab compared with oral bisphosphonates for the treatment of osteoporosis. DATA SOURCES: Two comprehensive PubMed literature searches (from data inception to December 2017) were performed. The first search included the terms osteoporosis, denosumab, bisphosphonate, and adherence or persistence or compliance or preference. The search terms osteoporosis, denosumab, cost, and effectiveness were used in the second literature search...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29589776/inter-rater-reliability-of-dartfish-tm-movement-analysis-software-for-measuring-maximum-flexion-and-extension-at-the-hip-and-knee-in-older-adults-with-osteoporosis-and-osteopenia
#5
Tyler Allen, Zachary Hollingham, James MacWhirter, Mark Welsh, Ahmed Negm, Jonathan D Adachi, Norma J MacIntyre
Various methods are used to measure hip and knee joint motion angles; however, their use is often limited by cost or inability to measure dynamic movements. The assessment of movement patterns is clinically useful in individuals with osteoporosis (OP) and osteopenia (OPe) through its potential to optimize fracture risk assessment. This study evaluates the inter-rater reliability of using DartfishTM 2-D Motion Analysis Software to measure maximum flexion and extension angles at the hip and knee in individuals with OP or OPe while performing five tasks of the Safe Functional Motion test...
March 28, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29567842/prevalence-of-potentially-inappropriate-prescribing-in-a-subpopulation-of-older-european-clinical-trial-participants-a-cross-sectional-study
#6
David O Riordan, Carole Elodie Aubert, Kieran A Walsh, Anette Van Dorland, Nicolas Rodondi, Robert S Du Puy, Rosalinde K E Poortvliet, Jacobijn Gussekloo, Carol Sinnott, Stephen Byrne, Rose Galvin, J Wouter Jukema, Simon P Mooijaart, Christine Baumgartner, Vera McCarthy, Elaine K Walsh, Tinh-Hai Collet, Olaf M Dekkers, Manuel R Blum, Patricia M Kearney
OBJECTIVES: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. DESIGN: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. PARTICIPANTS: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29527173/obesity-metabolic-syndrome-and-musculoskeletal-disease-common-inflammatory-pathways-suggest-a-central-role-for-loss-of-muscle-integrity
#7
REVIEW
Kelsey H Collins, Walter Herzog, Graham Z MacDonald, Raylene A Reimer, Jaqueline L Rios, Ian C Smith, Ronald F Zernicke, David A Hart
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically, or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regarding its pathophysiological link to chronic cardiovascular conditions and type 2 diabetes, the musculoskeletal (MSK) complications (i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#8
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29432613/circulating-dkk1-and-trail-are-associated-with-cognitive-decline-in-community-dwelling-older-adults-with-cognitive-concerns
#9
Ryan D Ross, Raj C Shah, Sue Leurgans, Teodoro Bottligieri, Robert S Wilson, D Rick Sumner
Background: Osteoporosis and Alzheimer's disease (AD) are common diseases of aging that would seem to be unrelated, but may be linked through the influence of bone-derived signals on brain function. The current study aimed to investigate the relationship between circulating levels of bone-related biomarkers and cognition. Methods: The population included 103 community-dwelling older individuals with memory concerns but without cognitive impairment. A global cognition summary measure was collected at baseline and 6, 12, and 18-months post-enrollment by converting raw scores from 19 cognitive function tests to z-scores and averaging...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29397408/bisphosphonate-use-after-clinical-fracture-and-risk-of-new-fracture
#10
J Bergman, A Nordström, P Nordström
Among older adults with a previous fracture, treatment for osteoporosis was initially associated with a higher risk of new fracture. However, the relative risk of new fracture decreased over time, a trend that is consistent with a beneficial effect, as treatment for osteoporosis is prescribed to reduce high fracture risks. INTRODUCTION: The purpose of this study was to examine whether bisphosphonate use is associated with a lower risk of new fracture after a clinical fracture in older adults...
February 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29392851/do-fda-label-changes-work-assessment-of-the-2010-class-label-change-for-proton-pump-inhibitors-using-the-sentinel-system-s-analytic-tools
#11
Rachel E Sobel, Andrew Bate, James Marshall, Kevin Haynes, Nandini Selvam, Vinit Nair, Gregory Daniel, Jeffrey S Brown, Robert F Reynolds
PURPOSE: To pilot use of the US Food and Drug Administration's (FDA's) Sentinel System data and analytic tools by a non-FDA stakeholder through the Innovation in Medical Evidence Development and Surveillance system of the Reagan Udall Foundation. We evaluated the US FDA 2010 proton pump inhibitor (PPI) class label change that warned of increased risk of bone fracture, to use PPIs for the lowest dose and shortest duration, and to manage bone status for those at risk for osteoporosis. METHODS: The cohort consisted of adults aged 18 years or older prescribed PPIs without fracture risk factors...
February 2, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29354738/inpatient-morbidity-after-spinal-deformity-surgery-in-patients-with-movement-disorders
#12
Rafael De la Garza Ramos, C Rory Goodwin, Amit Jain, Daniel Martinez-Ramirez, Isaac O Karikari, Daniel M Sciubba
Background: To investigate the inpatient perioperative morbidity rate of patients with movement disorders (MD) after spinal deformity surgery. Methods: The Nationwide Inpatient Sample database from 2002 to 2011 was queried to identify adult patients with MD who underwent spinal deformity surgery. Complication rates were compared between patients with MD and controls. A multiple logistic regression analysis was conducted to assess the effect of MD on outcome. Results: A total of 365 patients with MD (3...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29319880/competing-risks-of-fracture-and-death-in-older-adults-with-chronic-kidney-disease
#13
Rasheeda K Hall, Richard Sloane, Carl Pieper, Courtney Van Houtven, Joanne LaFleur, Robert Adler, Cathleen Colón-Emeric
OBJECTIVES: To examine whether chronic kidney disease (CKD) at any stage is associated with fracture risk after adjusting for competing mortality and to determine whether age or race modify the relationship between CKD and fracture risk. DESIGN: Prospective cohort study. SETTING: Department of Veterans Affairs (VA) national healthcare system. PARTICIPANTS: Men receiving VA primary care aged 65 and older with no history of fracture or osteoporosis therapy (N = 712, 918)...
March 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29314261/future-osteoporotic-fracture-risk-related-to-lumbar-vertebral-trabecular-attenuation-measured-at-routine-body-ct
#14
Scott J Lee, Peter M Graffy, Ryan D Zea, Timothy J Ziemlewicz, Perry J Pickhardt
We sought to determine if vertebral trabecular attenuation values measured on routine body computed tomography (CT) scans obtained for a variety of unrelated indications can predict future osteoporotic fractures at multiple skeletal sites. For this Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved retrospective cohort study, trabecular attenuation of the first lumbar vertebra was measured in 1966 consecutive older adults who underwent chest and/or abdominal CT at a single institution over the course of 1 year...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29308969/social-cognitive-or-learning-theory-use-to-improve-self-efficacy-in-musculoskeletal-rehabilitation-a-systematic-review-and-meta-analysis
#15
Cameron Ghazi, John Nyland, Rumeal Whaley, Thomas Rogers, Jeff Wera, Cameron Henzman
OBJECTIVE: To review the rehabilitation research methodological quality and intervention effectiveness of studies that used social cognitive or learning theory principles to improve self-efficacy in patients with orthopedic or musculoskeletal conditions. DESIGN: A systematic literature review and meta-analysis of peer reviewed studies published in English was performed using the OVID and SPORTDiscus databases. Initial search terms were "social cognitive theory" or "social learning theory" combined with "rehabilitation"...
July 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29305651/-management-of-osteoporosis-after-fragility-fractures
#16
M Gosch, U Stumpf, C Kammerlander, W Böcker, H J Heppner, S Wicklein
Osteoporosis is defined as a systemic bone disease with decreased bone strength and an increased susceptibility for fractures. Older people in particular face an increased risk of fractures. These kind of fractures are usually caused by an inadequate trauma and are the so-called fragility fractures. In older adults immediate fracture stabilization and early mobilization have become the standard procedure after a fragility fracture. Treatment of the underlying osteoporosis often plays a minor role in clinical practice...
January 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29305636/lower-lean-mass-measured-by-dual-energy-x-ray-absorptiometry-dxa-is-not-associated-with-increased-risk-of-hip-fracture-in-women-the-framingham-osteoporosis-study
#17
Robert R McLean, Douglas P Kiel, Sarah D Berry, Kerry E Broe, Xiaochun Zhang, L Adrienne Cupples, Marian T Hannan
Although muscle mass influences strength in older adults, it is unclear whether low lean mass measured by dual-energy X-ray absorptiometry (DXA) is an independent risk factor for hip fracture. Our objective was to determine the association between DXA lean mass and incident hip fracture risk among 1978 women aged 50 years and older participating in the Framingham Study Original and Offspring cohorts. Leg and total body lean mass (kg) were assessed from whole-body DXA scans collected in 1992-2001. Hip fracture follow-up extended from DXA assessment to the occurrence of fracture, death, drop-out, or end of follow-up in 2007...
January 5, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29304836/osteoporotic-fractures-and-obesity-affect-frailty-progression-a-longitudinal-analysis-of-the-canadian-multicentre-osteoporosis-study
#18
Olga Gajic-Veljanoski, Alexandra Papaioannou, Courtney Kennedy, George Ioannidis, Claudie Berger, Andy Kin On Wong, Kenneth Rockwood, Susan Kirkland, Parminder Raina, Lehana Thabane, Jonathan D Adachi
BACKGROUND: Despite knowing better how to screen older adults, understanding how frailty progression might be modified is unclear. We explored effects of modifiable and non-modifiable factors on changes in frailty in community-dwelling adults aged 50+ years who participated in the Canadian Multicentre Osteoporosis Study (CaMos). METHODS: Rates of change in frailty over 10 years were examined using the 30-item CaMos Frailty Index (CFI). Incident and prevalent low-trauma fractures were categorized by fracture site into hip, clinical vertebral and non-hip-non-vertebral fractures...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29279934/association-between-calcium-or-vitamin-d-supplementation-and-fracture-incidence-in-community-dwelling-older-adults-a-systematic-review-and-meta-analysis
#19
REVIEW
Jia-Guo Zhao, Xian-Tie Zeng, Jia Wang, Lin Liu
Importance: The increased social and economic burdens for osteoporosis-related fractures worldwide make the prevention of such injuries a major public health goal. Previous studies have reached mixed conclusions regarding the association between calcium, vitamin D, or combined calcium and vitamin D supplements and fracture incidence in older adults. Objective: To investigate whether calcium, vitamin D, or combined calcium and vitamin D supplements are associated with a lower fracture incidence in community-dwelling older adults...
December 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29251181/assessment-of-geriatric-predictors-of-adherence-to-zoledronic-acid-treatment-for-osteoporosis-a-prospective-follow-up-study
#20
Ilker Tasci, Umit Cintosun, Umut Safer, M Ilkin Naharci, Ergun Bozoglu, Aydogan Aydogdu, Huseyin Doruk
Objectives Discontinuation of bisphosphonate treatment remains high even with the long acting parenteral options. Whether there are some unidentified causes of noncompliance more specific to aged individuals is unknown. The aim of this study was to investigate baseline predictors of adherence to Zoledronic acid (ZOL) infusions among non-demented older adults with osteoporosis. Methods Patients aged ≥ 65 years who received a first ever ZOL infusion for osteoporosis were prospectively enrolled. Risk factors for osteoporosis and fractures, comorbidities, geriatric assessment measures, including depression, and anticholinergic burden were determined at baseline...
December 18, 2017: Acta Clinica Belgica
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