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Osteoporosis older adults

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https://www.readbyqxmd.com/read/27910102/association-of-serum-klotho-with-loss-of-bone-mineral-density-and-fracture-risk-in-older-adults
#1
Didier Chalhoub, Elisa Marques, Osorio Meirelles, Richard D Semba, Luigi Ferrucci, Suzanne Satterfield, Michael Nevitt, Jane A Cauley, Tamara Harris
OBJECTIVES: Klotho deficiency has been previously linked to aging-like phenotypes such as osteoporosis, cognitive impairment, and sarcopenia. Low serum klotho was shown to be related to grip strength and disability. Nonetheless, no previous study has explored the association between serum klotho and fractures. The purpose of this report is to examine the relationship of serum klotho with bone mineral density (BMD) loss and fractures in older adults. DESIGN: The Health, Aging, and Body Composition (Health ABC) Study is a longitudinal cohort study of 3,075 community-dwelling older adults...
December 2, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27886696/a-review-of-osteoporosis-in-the-older-adult
#2
REVIEW
Paloma Alejandro, Florina Constantinescu
Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. The goal of managing osteoporosis is to prevent fractures. In men, osteoporosis is underrecognized and undertreated. More men than women die every year as a consequence of hip fractures. A review of diagnosis and treatment of osteoporosis is described in this article. Bisphosphonates are the first-line treatment for men and women. In the past several years, advances in bone biology have resulted in major therapeutic advances...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27874933/vitamin-d-supplementation-for-osteoporosis-in-older-adults-can-we-make-it-help-better
#3
C-H Dong, Q-M Gao, Z-M Wang, A-M Wang, P Zhen
With the increase of the average age of our population, the incidence of diseases specific for older adults has been increasing. One of such diseases is osteoporosis. The true incidence of osteoporosis is unknown. But the estimates indicate that this disease affects wide proportions of the population, ranging in millions or even ten millions in large countries like the United States. As this poses a significant burden on the health care system, interventions that could prevent or treat this condition are in the focus of clinical research...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27868084/the-association-between-bone-turnover-markers-and-kyphosis-in-community-dwelling-older-adults
#4
Corinne R McDaniels-Davidson, Donna Kritz-Silverstein, Mei-Hua Huang, Gail A Laughlin, Sarah Johnson, Jouko Haapalahti, Diane L Schneider, Elizabeth Barrett-Connor, Deborah M Kado
PURPOSE: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. METHODS: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/27866050/boucher-neuh%C3%A3-user-syndrome-a-rare-cause-of-inherited-hypogonadotropic-hypogonadism-a-case-of-two-adult-siblings-with-two-novel-mutations-in-pnpla6
#5
Jakob H Langdahl, Anja L Frederiksen, Nina Nguyen, Klaus Brusgaard, Claus B Juhl
Boucher Neuhäuser Syndrome (BNS) is a rare clinical syndrome with autosomal recessive inheritance defined by early-onset ataxia, hypogonadism and chorioretinal dystrophy. We present two siblings diagnosed with BNS in late adult life identified with compound heterozygous state of two novel PNPLA6 mutations. Five healthy siblings were non- or heterozygous carriers of the mutations. The cases, which presented with ataxia in childhood and hypogonadotropic hypogonadism (HH), were diagnosed at age 17 and 25, respectively, when examined for delayed puberty...
November 16, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27851678/osteoporosis-preventive-practice-between-veteran-and-nonveteran-older-adults-findings-from-patient-reported-data
#6
Eun-Shim Nahm, Kathleen Charters, Eunhae Yoo, Linda M Keldsen, Shijun Zhu
BACKGROUND: Veterans are prone to bone-related illnesses due to multiple risk factors such as prior injuries. The aim of this study was to compare trends in osteoporosis preventive practices between veteran and nonveteran older adults. METHODS: This was a secondary data analysis using selected baseline data and discussion postings from an online bone health trial including participants (N = 866) recruited from My HealtheVet (MHV) and SeniorNet (SN). Data were analyzed using descriptive statistics, parametric statistics, and content analysis...
November 2016: Orthopaedic Nursing
https://www.readbyqxmd.com/read/27845703/older-swedish-adults-with-high-self-perceived-health-show-optimal-25-hydroxyvitamin-d-levels-whereas-vitamin-d-status-is-low-in-patients-with-high-disease-burden
#7
Martin Carlsson, Pär Wanby, Lars Brudin, Erik Lexne, Karin Mathold, Rebecca Nobin, Lisa Ericson, Ola Nordqvist, Göran Petersson
Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people ≥75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27798733/a-novel-accelerometer-based-method-to-describe-day-to-day-exposure-to-potentially-osteogenic-vertical-impacts-in-older-adults-findings-from-a-multi-cohort-study
#8
K Hannam, K C Deere, A Hartley, E M Clark, J Coulson, A Ireland, C Moss, M H Edwards, E Dennison, T Gaysin, R Cooper, A Wong, J S McPhee, C Cooper, D Kuh, J H Tobias
: This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported activity. INTRODUCTION: We aimed to validate a novel method for evaluating day-to-day higher impact weight-bearing physical activity (PA) in older adults, thought to be important in protecting against osteoporosis, by comparing results between four cohorts varying in age and activity levels, and with self-reported PA levels...
October 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27766589/assessment-of-distal-radius-bone-mineral-density-in-osteoporosis-patients-receiving-denosumab-including-those-with-rheumatoid-arthritis-and-those-receiving-oral-glucocorticoids
#9
Hiroaki Matsuno
BACKGROUND AND OBJECTIVES: Recently, the osteoporosis treatment has attracted attention, and several drugs have been developed. Among these, bisphosphonates (BPs), parathyroid hormone (PTH) and anti-receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal (MAb) denosumab (DMAb) are the major osteoporosis agents. Several studies demonstrated that the effect of osteoporosis agents is evaluated by lumar or hip dual energy X-ray absorptiometry (DXA). However, private clinic commonly use the radial DXA...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27754270/sy-16-4-vitamin-d-with-or-without-calcium-supplementation-in-relation-to-hypertension
#10
Adriana Van Ballegooijen
Cardiovascular disease and osteoporosis are major age-related causes of morbidity and premature death that occur among older adults. Emerging evidence suggests that calcium from bone is deposited in the arteries. This leads to calcification in valves and vessels, which is associated with a 3-4 fold higher risk of coronary heart disease. Calcium and vitamin D supplementation is frequently advised in older adults for the prevention of osteoporosis and to reduce the risk of fractures and falls. However, recent RCT's showed that individuals taking calcium and vitamin D were at higher risk of cardiovascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754067/os-16-06-risk-factors-for-serious-fall-injuries-following-initiation-of-antihypertensive-medication
#11
Kristi Reynolds, Daichi Shimbo, C Barrett Bowling, Luqin Deng, Adam Bress, John Sim, Paul Muntner
OBJECTIVE: To identify risk factors for serious fall injuries following initiation of antihypertensive medication among older adults. DESIGN AND METHOD: We conducted a retrospective cohort study using a 5% random sample of people with Medicare health insurance, a government program for older US adults. The analysis was restricted to patients with a diagnosis of hypertension who initiated antihypertensive medication between 2007 and 2011. Initiation was defined by the first antihypertensive medication fill in this time period preceded by 365 days with no antihypertensive medication fills...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27738713/exercise-muscle-and-the-applied-load-bone-strength-balance
#12
L Giangregorio, R El-Kotob
A fracture occurs when the applied load is greater than the bone can withstand. Clinical practice guidelines for the management of osteoporosis include recommendations for exercise; one of the few therapies where the proposed anti-fracture mechanisms that include effects on both bone strength and applied loads, where applied loads can come in the form of a fall, externally applied loads, body weight, or muscle forces. The aim of this review is to provide an overview of the clinical evidence pertaining to the potential efficacy of exercise for preventing fractures in older adults, including its direct effects on outcomes along the causal pathway to fractures (e...
October 13, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27735874/association-of-osteoporosis-self-assessment-tool-for-asians-osta-score-with-clinical-presentation-and-expenditure-in-hospitalized-trauma-patients-with-femoral-fractures
#13
Chien-Chang Chen, Cheng-Shyuan Rau, Shao-Chun Wu, Pao-Jen Kuo, Yi-Chun Chen, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: A cross-sectional study to investigate the association of Osteoporosis Self-Assessment Tool for Asians (OSTA) score with clinical presentation and expenditure of hospitalized adult trauma patients with femoral fractures. Methods: According to the data retrieved from the Trauma Registry System between 1 January 2009 and 31 December 2015, a total of 2086 patients aged ≥40 years and hospitalized for treatment of traumatic femoral bone fracture were categorized as high-risk patients (OSTA < -4, n = 814), medium-risk patients (-1 ≥ OSTA ≥ -4, n = 634), and low-risk patients (OSTA > -1, n = 638)...
October 10, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27733660/pilot-study-for-implementing-an-osteoporosis-education-and-exercise-program-in-an-assisted-living-facility-and-senior-community
#14
Aparna P Nanduri, Sally Fullman, Lori Morell, Steve Buyske, Mary L Wagner
BACKGROUND: Project Healthy Bones (PHB) is a 24-week, peer-led exercise and education program for older adults at risk of osteoporosis. METHOD: Residents from an assisted living and senior community program were enrolled after medical clearance. Participant demographics, geriatric fitness assessments, exercise logs, quizzes, and surveys were collected at baseline and 24 weeks. Data were analyzed using paired t tests and ANOVA of change scores for the pooled data within the R statistical environment...
October 11, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/27730445/hiv-and-bone-complications-understudied-populations-and-new-management-strategies
#15
REVIEW
Michael T Yin, Todd T Brown
The higher risk of osteoporosis and fracture associated with HIV infection and certain antiretrovirals has been well established and the need for risk stratification among older adults increasingly recognized. This review focuses upon emerging data on bone complications with HIV/HCV coinfection, in children and adolescents, and with pre-exposure prophylaxis (PrEP), as well as new management strategies to minimize the negative effects of ART on bone.
December 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27714430/factors-associated-with-the-accuracy-of-self-reported-osteoporosis-in-the-community
#16
Tina D Cunningham, Sarah C DeShields
We examined the agreement between self-reported osteoporosis and bone mineral density (BMD) results through dual-energy x-ray absorptiometry (DXA) using data from a national representative sample taken from the US communities. Six-year data from the continuous National Health and Nutrition Examination Survey 2005-2006, 2007-2008, and 2009-2010 were merged. Participants included adults 50 years of age or older whose data appeared in both questionnaire and medical examination data files. Self-reported osteoporosis was defined by an affirmative response to a question in the osteoporosis questionnaire then compared with BMD-defined osteoporosis, defined by BMD values taken from the examination data...
October 6, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27709725/exploring-canadian-surgeons-decisions-about-postoperative-weight-bearing-for-their-hip-fracture-patients
#17
Leslie Carlin, Kathryn Sibley, Richard Jenkinson, Pia Kontos, Rhona McGlasson, Hans J Kreder, Susan Jaglal
For older adults with osteoporosis, a fall resulting in hip fracture is a life-changing event from which only one-third fully recover. Current best evidence argues strongly for elderly patients to bear weight on their repaired hip fracture immediately after their surgery to maximize their chances of full or nearly full recovery. Patient stakeholders in Canada have argued that some surgeons fail to issue "weight-bearing-as-tolerated" (WBAT) orders in all eligible cases, protecting their bony repair but contributing to increased mortality and long-term disability rates...
October 6, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27692129/impact-of-asthma-on-mortality-in-older-women-an-australian-cohort-study-of-10-413-women
#18
Parivash Eftekhari, Peta M Forder, Tazeen Majeed, Julie E Byles
BACKGROUND: Comorbid conditions frequently coexist with asthma in older adults and can alter the natural history of asthma, complicating management and affecting overall prognosis and survival. OBJECTIVES: This study investigates the impact of asthma on mortality among older women, with a specific interest in influence of comorbidities and social factors on survival of older women with asthma. DESIGN: Participants were from the Australian Longitudinal Study on Women's Health and were born between 1921 and 1926...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27682248/hypocalcaemia-after-denosumab-in-older-people-following-fracture
#19
Jessica Chen, Peter Smerdely
: Hypocalcaemia following denosumab therapy can be observed in older adults. This is more common if their pre-treatment corrected serum calcium concentrations are less than 2.28 mmol/L. Denosumab remains a safe treatment in older people but we recommend a cautious approach in people at risk. INTRODUCTION: Previous studies have indicated that denosumab, an anti-RANK ligand (RANKL) monoclonal antibody, for treatment of osteoporosis is well-tolerated. There is little data specifically regarding its adverse effect profile in a hospitalised older person...
September 28, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27669735/bone-densitometry-in-children-and-adolescents
#20
Laura K Bachrach, Catherine M Gordon
Concerns about bone health and potential fragility in children and adolescents have led to a high interest in bone densitometry. Pediatric patients with genetic and acquired chronic diseases, immobility, and inadequate nutrition may fail to achieve expected gains in bone size, mass, and strength, leaving them vulnerable to fracture. In older adults, bone densitometry has been shown to predict fracture risk and reflect response to therapy. The role of densitometry in the management of children at risk of bone fragility is less clear...
September 26, 2016: Pediatrics
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