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Osteoporosis older adults

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https://www.readbyqxmd.com/read/28074252/high-dietary-sodium-intake-is-associated-with-low-bone-mass-in-postmenopausal-women-korea-national-health-and-nutrition-examination-survey-2008-2011
#1
S-J Kwon, Y-C Ha, Y Park
: The present cross-sectional study performed using data from the Korea National Health and Nutrition Examination Survey in 9526 women older than 18 years of age demonstrates that high sodium intake is associated with lower bone mineral density and sodium intake ≥2000 mg/day is a risk factor for osteoporosis in postmenopausal women. INTRODUCTION: Several studies have reported that large amount of dietary sodium intake is highly associated with elevated urinary calcium...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28024315/patient-physician-and-health-system-factors-influencing-the-quality-of-antidepressant-and-sedative-prescribing-for-older-community-dwelling-adults
#2
Rian Marie Extavour, Matthew Perri
OBJECTIVE: To identify determinants of potentially inappropriate (PI) antidepressant and anxiolytic/sedative prescribing for older, community-dwelling adults. DATA SOURCES/STUDY SETTING: Office visits from the 2010 National Ambulatory Medical Care Survey. STUDY DESIGN: A cross-sectional study measuring associations between various patient and physician factors and prescribing of PI antidepressants, and PI sedatives among elderly, using Beers 2012/2015 criteria, a clinical decision model, and multivariate logistic regressions...
December 26, 2016: Health Services Research
https://www.readbyqxmd.com/read/28013364/rest-activity-patterns-and-falls-and-fractures-in-older-men
#3
Tara S Rogers, Terri L Blackwell, Nancy E Lane, Greg Tranah, Eric S Orwoll, Jane A Cauley, Sonia Ancoli-Israel, Katie L Stone, Steven R Cummings, Peggy M Cawthon
: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. PURPOSE: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men...
December 24, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27975302/vitamin-d-deficiency-is-associated-with-functional-decline-and-falls-in-frail-elderly-women-despite-supplementation
#4
M P Kotlarczyk, S Perera, M A Ferchak, D A Nace, N M Resnick, S L Greenspan
: We examined the impact of daily supplementation on vitamin D deficiency, function, and falls in female long-term care residents. Initial vitamin D deficiency was associated with greater functional decline and increased fall risk despite guideline-recommended supplementation, highlighting the importance of preventing vitamin D deficiency in frail elderly. INTRODUCTION: Institute of Medicine (IOM) guidelines recommend 800 IU vitamin D daily for older adults and maintaining serum 25-hydroxyvitamin D [25(OH) D] above 20 ng/ml for optimal skeletal health...
December 15, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27966104/the-impact-of-the-new-national-bone-health-alliance-nbha-diagnostic-criteria-on-the-prevalence-of-osteoporosis-in-the-usa
#5
N C Wright, K G Saag, B Dawson-Hughes, S Khosla, E S Siris
: We evaluated the prevalence of osteoporosis using the osteoporosis diagnostic criteria developed by the National Bone Health Alliance (NBHA), which includes qualified fractures, FRAX score in addition to bone mineral density (BMD). The expanded definition increases the prevalence compared to BMD alone definitions; however, it may better identify those at elevated fracture risk. PURPOSE: The purpose of this paper is to estimate the prevalence of osteoporosis in US adults ≥50 years using the NBHA osteoporosis diagnostic criteria...
December 13, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27939817/late-onset-hereditary-hypophosphatemic-rickets-with-hypercalciuria-hhrh-due-to-mutation-of-slc34a3-npt2c
#6
Gauri Dhir, Dong Li, Hakon Hakonarson, Michael A Levine
OBJECTIVE: To identify a genetic basis for markedly reduced bone density and multiple fractures in an adult patient with hypophosphatemia and hypercalciuria. SUBJECTS: A 54-year-old Vietnamese man, his unaffected two daughters and wife. METHODS: We performed biochemical studies and sequenced the SLC34A3 gene using genomic DNA from peripheral blood mononuclear cells. RESULTS: Biochemical evaluation of the proband revealed hypophosphatemia with increased renal phosphate wasting, hypercalciuria, low serum parathyroid hormone (PTH) and an elevated serum 1,25(OH)2D level...
December 7, 2016: Bone
https://www.readbyqxmd.com/read/27924380/adherence-to-the-2006-american-heart-association-s-diet-and-lifestyle-recommendations-for-cardiovascular-disease-risk-reduction-is-associated-with-bone-mineral-density-in-older-chinese
#7
G D Chen, D Ding, H Y Tian, Y Y Zhu, W T Cao, C Wang, Y M Chen
: This cross-sectional study investigated the association between the modified 2006 American Heart Association Diet and Lifestyle Recommendations (AHA-DLR) and bone mineral density in Chinese adults. We found that better adherence to the AHA-DLR associated with higher bone mineral density (BMD) at multiple sites. INTRODUCTION: Accumulating evidence shows that cardiovascular disease (CVD) and osteoporosis are associated with each other, yet little research has focused on whether strategies to reduce CVD risk could also benefit bone health...
December 6, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27910102/association-of-serum-klotho-with-loss-of-bone-mineral-density-and-fracture-risk-in-older-adults
#8
Didier Chalhoub, Elisa Marques, Osorio Meirelles, Richard D Semba, Luigi Ferrucci, Suzanne Satterfield, Michael Nevitt, Jane A Cauley, Tamara Harris
OBJECTIVES: Klotho deficiency has been previously linked to aging-like phenotypes such as osteoporosis, cognitive impairment, and sarcopenia. Low serum klotho was shown to be related to grip strength and disability. Nonetheless, no previous study has explored the association between serum klotho and fractures. The purpose of this report is to examine the relationship of serum klotho with bone mineral density (BMD) loss and fractures in older adults. DESIGN: The Health, Aging, and Body Composition (Health ABC) Study is a longitudinal cohort study of 3,075 community-dwelling older adults...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27886696/a-review-of-osteoporosis-in-the-older-adult
#9
REVIEW
Paloma Alejandro, Florina Constantinescu
Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. The goal of managing osteoporosis is to prevent fractures. In men, osteoporosis is underrecognized and undertreated. More men than women die every year as a consequence of hip fractures. A review of diagnosis and treatment of osteoporosis is described in this article. Bisphosphonates are the first-line treatment for men and women. In the past several years, advances in bone biology have resulted in major therapeutic advances...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27874933/vitamin-d-supplementation-for-osteoporosis-in-older-adults-can-we-make-it-help-better
#10
C-H Dong, Q-M Gao, Z-M Wang, A-M Wang, P Zhen
With the increase of the average age of our population, the incidence of diseases specific for older adults has been increasing. One of such diseases is osteoporosis. The true incidence of osteoporosis is unknown. But the estimates indicate that this disease affects wide proportions of the population, ranging in millions or even ten millions in large countries like the United States. As this poses a significant burden on the health care system, interventions that could prevent or treat this condition are in the focus of clinical research...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27868084/the-association-between-bone-turnover-markers-and-kyphosis-in-community-dwelling-older-adults
#11
Corinne R McDaniels-Davidson, Donna Kritz-Silverstein, Mei-Hua Huang, Gail A Laughlin, Sarah Johnson, Jouko Haapalahti, Diane L Schneider, Elizabeth Barrett-Connor, Deborah M Kado
PURPOSE: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults. METHODS: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/27866050/boucher-neuh%C3%A3-user-syndrome-a-rare-cause-of-inherited-hypogonadotropic-hypogonadism-a-case-of-two-adult-siblings-with-two-novel-mutations-in-pnpla6
#12
Jakob H Langdahl, Anja L Frederiksen, Nina Nguyen, Klaus Brusgaard, Claus B Juhl
Boucher Neuhäuser Syndrome (BNS) is a rare clinical syndrome with autosomal recessive inheritance defined by early-onset ataxia, hypogonadism and chorioretinal dystrophy. We present two siblings diagnosed with BNS in late adult life identified with compound heterozygous state of two novel PNPLA6 mutations. Five healthy siblings were non- or heterozygous carriers of the mutations. The cases, which presented with ataxia in childhood and hypogonadotropic hypogonadism (HH), were diagnosed at age 17 and 25, respectively, when examined for delayed puberty...
November 16, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27851678/osteoporosis-preventive-practice-between-veteran-and-nonveteran-older-adults-findings-from-patient-reported-data
#13
Eun-Shim Nahm, Kathleen Charters, Eunhae Yoo, Linda M Keldsen, Shijun Zhu
BACKGROUND: Veterans are prone to bone-related illnesses due to multiple risk factors such as prior injuries. The aim of this study was to compare trends in osteoporosis preventive practices between veteran and nonveteran older adults. METHODS: This was a secondary data analysis using selected baseline data and discussion postings from an online bone health trial including participants (N = 866) recruited from My HealtheVet (MHV) and SeniorNet (SN). Data were analyzed using descriptive statistics, parametric statistics, and content analysis...
November 2016: Orthopaedic Nursing
https://www.readbyqxmd.com/read/27845703/older-swedish-adults-with-high-self-perceived-health-show-optimal-25-hydroxyvitamin-d-levels-whereas-vitamin-d-status-is-low-in-patients-with-high-disease-burden
#14
Martin Carlsson, Pär Wanby, Lars Brudin, Erik Lexne, Karin Mathold, Rebecca Nobin, Lisa Ericson, Ola Nordqvist, Göran Petersson
Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people ≥75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27798733/a-novel-accelerometer-based-method-to-describe-day-to-day-exposure-to-potentially-osteogenic-vertical-impacts-in-older-adults-findings-from-a-multi-cohort-study
#15
K Hannam, K C Deere, A Hartley, E M Clark, J Coulson, A Ireland, C Moss, M H Edwards, E Dennison, T Gaysin, R Cooper, A Wong, J S McPhee, C Cooper, D Kuh, J H Tobias
: This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported activity. INTRODUCTION: We aimed to validate a novel method for evaluating day-to-day higher impact weight-bearing physical activity (PA) in older adults, thought to be important in protecting against osteoporosis, by comparing results between four cohorts varying in age and activity levels, and with self-reported PA levels...
October 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27766589/assessment-of-distal-radius-bone-mineral-density-in-osteoporosis-patients-receiving-denosumab-including-those-with-rheumatoid-arthritis-and-those-receiving-oral-glucocorticoids
#16
Hiroaki Matsuno
BACKGROUND AND OBJECTIVES: Recently, the osteoporosis treatment has attracted attention, and several drugs have been developed. Among these, bisphosphonates (BPs), parathyroid hormone (PTH) and anti-receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal (MAb) denosumab (DMAb) are the major osteoporosis agents. Several studies demonstrated that the effect of osteoporosis agents is evaluated by lumar or hip dual energy X-ray absorptiometry (DXA). However, private clinic commonly use the radial DXA...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27754270/sy-16-4-vitamin-d-with-or-without-calcium-supplementation-in-relation-to-hypertension
#17
Adriana Van Ballegooijen
Cardiovascular disease and osteoporosis are major age-related causes of morbidity and premature death that occur among older adults. Emerging evidence suggests that calcium from bone is deposited in the arteries. This leads to calcification in valves and vessels, which is associated with a 3-4 fold higher risk of coronary heart disease. Calcium and vitamin D supplementation is frequently advised in older adults for the prevention of osteoporosis and to reduce the risk of fractures and falls. However, recent RCT's showed that individuals taking calcium and vitamin D were at higher risk of cardiovascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754067/os-16-06-risk-factors-for-serious-fall-injuries-following-initiation-of-antihypertensive-medication
#18
Kristi Reynolds, Daichi Shimbo, C Barrett Bowling, Luqin Deng, Adam Bress, John Sim, Paul Muntner
OBJECTIVE: To identify risk factors for serious fall injuries following initiation of antihypertensive medication among older adults. DESIGN AND METHOD: We conducted a retrospective cohort study using a 5% random sample of people with Medicare health insurance, a government program for older US adults. The analysis was restricted to patients with a diagnosis of hypertension who initiated antihypertensive medication between 2007 and 2011. Initiation was defined by the first antihypertensive medication fill in this time period preceded by 365 days with no antihypertensive medication fills...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27738713/exercise-muscle-and-the-applied-load-bone-strength-balance
#19
REVIEW
L Giangregorio, R El-Kotob
A fracture occurs when the applied load is greater than the bone can withstand. Clinical practice guidelines for the management of osteoporosis include recommendations for exercise; one of the few therapies where the proposed anti-fracture mechanisms that include effects on both bone strength and applied loads, where applied loads can come in the form of a fall, externally applied loads, body weight, or muscle forces. The aim of this review is to provide an overview of the clinical evidence pertaining to the potential efficacy of exercise for preventing fractures in older adults, including its direct effects on outcomes along the causal pathway to fractures (e...
January 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27735874/association-of-osteoporosis-self-assessment-tool-for-asians-osta-score-with-clinical-presentation-and-expenditure-in-hospitalized-trauma-patients-with-femoral-fractures
#20
Chien-Chang Chen, Cheng-Shyuan Rau, Shao-Chun Wu, Pao-Jen Kuo, Yi-Chun Chen, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: A cross-sectional study to investigate the association of Osteoporosis Self-Assessment Tool for Asians (OSTA) score with clinical presentation and expenditure of hospitalized adult trauma patients with femoral fractures. Methods: According to the data retrieved from the Trauma Registry System between 1 January 2009 and 31 December 2015, a total of 2086 patients aged ≥40 years and hospitalized for treatment of traumatic femoral bone fracture were categorized as high-risk patients (OSTA < -4, n = 814), medium-risk patients (-1 ≥ OSTA ≥ -4, n = 634), and low-risk patients (OSTA > -1, n = 638)...
October 10, 2016: International Journal of Environmental Research and Public Health
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