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Osteoporosis older adults

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https://www.readbyqxmd.com/read/29432613/circulating-dkk1-and-trail-are-associated-with-cognitive-decline-in-community-dwelling-older-adults-with-cognitive-concerns
#1
Ryan D Ross, Raj C Shah, Sue Leurgans, Teodoro Bottligieri, Robert S Wilson, D Rick Sumner
Background: Osteoporosis and Alzheimer's disease (AD) are common diseases of aging that would seem to be unrelated, but may be linked through the influence of bone-derived signals on brain function. The current study aimed to investigate the relationship between circulating levels of bone-related biomarkers and cognition. Methods: The population included 103 community-dwelling older individuals with memory concerns but without cognitive impairment. A global cognition summary measure was collected at baseline and 6, 12, and 18-months post-enrollment by converting raw scores from 19 cognitive function tests to z-scores and averaging...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29397408/bisphosphonate-use-after-clinical-fracture-and-risk-of-new-fracture
#2
J Bergman, A Nordström, P Nordström
Among older adults with a previous fracture, treatment for osteoporosis was initially associated with a higher risk of new fracture. However, the relative risk of new fracture decreased over time, a trend that is consistent with a beneficial effect, as treatment for osteoporosis is prescribed to reduce high fracture risks. INTRODUCTION: The purpose of this study was to examine whether bisphosphonate use is associated with a lower risk of new fracture after a clinical fracture in older adults...
February 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29392851/do-fda-label-changes-work-assessment-of-the-2010-class-label-change-for-proton-pump-inhibitors-using-the-sentinel-system-s-analytic-tools
#3
Rachel E Sobel, Andrew Bate, James Marshall, Kevin Haynes, Nandini Selvam, Vinit Nair, Gregory Daniel, Jeffrey S Brown, Robert F Reynolds
PURPOSE: To pilot use of the US Food and Drug Administration's (FDA's) Sentinel System data and analytic tools by a non-FDA stakeholder through the Innovation in Medical Evidence Development and Surveillance system of the Reagan Udall Foundation. We evaluated the US FDA 2010 proton pump inhibitor (PPI) class label change that warned of increased risk of bone fracture, to use PPIs for the lowest dose and shortest duration, and to manage bone status for those at risk for osteoporosis. METHODS: The cohort consisted of adults aged 18 years or older prescribed PPIs without fracture risk factors...
February 2, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29354738/inpatient-morbidity-after-spinal-deformity-surgery-in-patients-with-movement-disorders
#4
Rafael De la Garza Ramos, C Rory Goodwin, Amit Jain, Daniel Martinez-Ramirez, Isaac O Karikari, Daniel M Sciubba
Background: To investigate the inpatient perioperative morbidity rate of patients with movement disorders (MD) after spinal deformity surgery. Methods: The Nationwide Inpatient Sample database from 2002 to 2011 was queried to identify adult patients with MD who underwent spinal deformity surgery. Complication rates were compared between patients with MD and controls. A multiple logistic regression analysis was conducted to assess the effect of MD on outcome. Results: A total of 365 patients with MD (3...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29319880/competing-risks-of-fracture-and-death-in-older-adults-with-chronic-kidney-disease
#5
Rasheeda K Hall, Richard Sloane, Carl Pieper, Courtney Van Houtven, Joanne LaFleur, Robert Adler, Cathleen Colón-Emeric
OBJECTIVES: To examine whether chronic kidney disease (CKD) at any stage is associated with fracture risk after adjusting for competing mortality and to determine whether age or race modify the relationship between CKD and fracture risk. DESIGN: Prospective cohort study. SETTING: Department of Veterans Affairs (VA) national healthcare system. PARTICIPANTS: Men receiving VA primary care aged 65 and older with no history of fracture or osteoporosis therapy (N = 712, 918)...
January 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29314261/future-osteoporotic-fracture-risk-related-to-lumbar-vertebral-trabecular-attenuation-measured-at-routine-body-ct
#6
Scott J Lee, Peter M Graffy, Ryan D Zea, Timothy J Ziemlewicz, Perry J Pickhardt
We sought to determine if vertebral trabecular attenuation values measured on routine body CT scans obtained for a variety of unrelated indications can predict future osteoporotic fractures at multiple skeletal sites. For this HIPAA-compliant and IRB-approved retrospective cohort study, trabecular attenuation of the first lumbar vertebra was measured in 1966 consecutive older adults who underwent chest and/or abdominal CT at a single institution over the course of one year. New pathologic fragility fractures that occurred after a patient's CT study date were identified through an electronic health record database query using ICD-9 codes for vertebral, hip, and extremity fractures...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29308969/social-cognitive-or-learning-theory-use-to-improve-self-efficacy-in-musculoskeletal-rehabilitation-a-systematic-review-and-meta-analysis
#7
Cameron Ghazi, John Nyland, Rumeal Whaley, Thomas Rogers, Jeff Wera, Cameron Henzman
OBJECTIVE: To review the rehabilitation research methodological quality and intervention effectiveness of studies that used social cognitive or learning theory principles to improve self-efficacy in patients with orthopedic or musculoskeletal conditions. DESIGN: A systematic literature review and meta-analysis of peer reviewed studies published in English was performed using the OVID and SPORTDiscus databases. Initial search terms were "social cognitive theory" or "social learning theory" combined with "rehabilitation"...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29305651/-management-of-osteoporosis-after-fragility-fractures
#8
M Gosch, U Stumpf, C Kammerlander, W Böcker, H J Heppner, S Wicklein
Osteoporosis is defined as a systemic bone disease with decreased bone strength and an increased susceptibility for fractures. Older people in particular face an increased risk of fractures. These kind of fractures are usually caused by an inadequate trauma and are the so-called fragility fractures. In older adults immediate fracture stabilization and early mobilization have become the standard procedure after a fragility fracture. Treatment of the underlying osteoporosis often plays a minor role in clinical practice...
January 5, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29305636/lower-lean-mass-measured-by-dual-energy-x-ray-absorptiometry-dxa-is-not-associated-with-increased-risk-of-hip-fracture-in-women-the-framingham-osteoporosis-study
#9
Robert R McLean, Douglas P Kiel, Sarah D Berry, Kerry E Broe, Xiaochun Zhang, L Adrienne Cupples, Marian T Hannan
Although muscle mass influences strength in older adults, it is unclear whether low lean mass measured by dual-energy X-ray absorptiometry (DXA) is an independent risk factor for hip fracture. Our objective was to determine the association between DXA lean mass and incident hip fracture risk among 1978 women aged 50 years and older participating in the Framingham Study Original and Offspring cohorts. Leg and total body lean mass (kg) were assessed from whole-body DXA scans collected in 1992-2001. Hip fracture follow-up extended from DXA assessment to the occurrence of fracture, death, drop-out, or end of follow-up in 2007...
January 5, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29304836/osteoporotic-fractures-and-obesity-affect-frailty-progression-a-longitudinal-analysis-of-the-canadian-multicentre-osteoporosis-study
#10
Olga Gajic-Veljanoski, Alexandra Papaioannou, Courtney Kennedy, George Ioannidis, Claudie Berger, Andy Kin On Wong, Kenneth Rockwood, Susan Kirkland, Parminder Raina, Lehana Thabane, Jonathan D Adachi
BACKGROUND: Despite knowing better how to screen older adults, understanding how frailty progression might be modified is unclear. We explored effects of modifiable and non-modifiable factors on changes in frailty in community-dwelling adults aged 50+ years who participated in the Canadian Multicentre Osteoporosis Study (CaMos). METHODS: Rates of change in frailty over 10 years were examined using the 30-item CaMos Frailty Index (CFI). Incident and prevalent low-trauma fractures were categorized by fracture site into hip, clinical vertebral and non-hip-non-vertebral fractures...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29279934/association-between-calcium-or-vitamin-d-supplementation-and-fracture-incidence-in-community-dwelling-older-adults-a-systematic-review-and-meta-analysis
#11
REVIEW
Jia-Guo Zhao, Xian-Tie Zeng, Jia Wang, Lin Liu
Importance: The increased social and economic burdens for osteoporosis-related fractures worldwide make the prevention of such injuries a major public health goal. Previous studies have reached mixed conclusions regarding the association between calcium, vitamin D, or combined calcium and vitamin D supplements and fracture incidence in older adults. Objective: To investigate whether calcium, vitamin D, or combined calcium and vitamin D supplements are associated with a lower fracture incidence in community-dwelling older adults...
December 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29251181/assessment-of-geriatric-predictors-of-adherence-to-zoledronic-acid-treatment-for-osteoporosis-a-prospective-follow-up-study
#12
Ilker Tasci, Umit Cintosun, Umut Safer, M Ilkin Naharci, Ergun Bozoglu, Aydogan Aydogdu, Huseyin Doruk
Objectives Discontinuation of bisphosphonate treatment remains high even with the long acting parenteral options. Whether there are some unidentified causes of noncompliance more specific to aged individuals is unknown. The aim of this study was to investigate baseline predictors of adherence to Zoledronic acid (ZOL) infusions among non-demented older adults with osteoporosis. Methods Patients aged ≥ 65 years who received a first ever ZOL infusion for osteoporosis were prospectively enrolled. Risk factors for osteoporosis and fractures, comorbidities, geriatric assessment measures, including depression, and anticholinergic burden were determined at baseline...
December 18, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29241825/sex-hormones-are-negatively-associated-with-vertebral-bone-marrow-fat
#13
Swaroop D Mistry, Gina N Woods, Sigurdur Sigurdsson, Susan K Ewing, Trisha F Hue, Gudny Eiriksdottir, Kaipin Xu, Joan F Hilton, Deborah M Kado, Vilmundur Gudnason, Tamara B Harris, Clifford J Rosen, Thomas F Lang, Xiaojuan Li, Ann V Schwartz
CONTEXT: Higher bone marrow fat (BMF)1 is associated with osteoporosis and reduced hematopoiesis. Exogenous estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown. OBJECTIVE: To determine if endogenous sex hormones are associated with BMF in older men and women. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Participants using medications that may affect BMF were excluded...
December 11, 2017: Bone
https://www.readbyqxmd.com/read/29241503/psychometric-properties-of-belief-measures-about-osteoporosis-and-its-control
#14
Lacey Alexander, Piyaorn Wajanatinapart, Diane Lauver
BACKGROUND AND PURPOSE: Osteoporosis (OP) is a chronic health condition with potentially serious consequences. Although preventive behaviors are important to control OP, many people do not engage in such behaviors. Although beliefs about preventive behaviors for OP influence such behaviors, we could not find psychometrically strong measures of such beliefs for use in planned research. Our initial study was done to assess the content validity, clarity, and internal consistency of belief measures regarding behaviors to control OP: perceived competence, perceived susceptibility, and perceived severity, based on relevant theories...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29229614/does-pride-really-come-before-a-fall-longitudinal-analysis-of-older-english-adults
#15
D McMinn, S J Fergusson, M Daly
OBJECTIVE: To test whether high levels of reported pride are associated with subsequent falls. DESIGN: Secondary analysis of the English Longitudinal Study of Ageing (ELSA) dataset. SETTING: Multi-wave longitudinal sample of non-institutionalised older English adults. PARTICIPANTS: ELSA cohort of 6415 participants at wave 5 (baseline, 2010/11), of whom 4964 were available for follow-up at wave 7 (follow-up, 2014/15)...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29218651/increasing-hip-fracture-rates-among-older-adults-in-ecuador-analysis-of-the-national-hospital-discharge-system-1999-2016
#16
Carlos H Orces, Enrique Lopez Gavilanez
The Ecuadorian hospital discharge system examined trends in hip fracture hospitalization rates among older adults. A significant upward trend in hip fracture rates occurred in both genders over the study period. INTRODUCTION: Previous research has reported increasing hip fracture rates in Ecuador. Thus, this study aimed to extend previous findings by examining the nationwide incidence of hip fractures among adults aged 65 years and older between 1999 and 2016. A secondary objective was to compare hip fracture trends among older Ecuadorians with their counterparts in the United States (U...
December 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29210932/score-distributions-of-the-balance-outcome-measure-for-elder-rehabilitation-boomer-in-community-dwelling-older-adults-with-vertebral-fracture
#17
Zachary M Brown, Jenna C Gibbs, Jonathan D Adachi, Maureen C Ashe, Keith D Hill, David L Kendler, Aliya Khan, Alexandra Papaioannou, Sadhana Prasad, John D Wark, Lora M Giangregorio
BACKGROUND AND PURPOSE: We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-dwelling women 65 years and older with vertebral fracture and to describe score distributions and potential ceiling and floor effects. METHODS: This was a secondary data analysis of baseline data from the Build Better Bones with Exercise randomized controlled trial using the BOOMER. A total of 141 women with osteoporosis and radiographically confirmed vertebral fracture were included...
November 28, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29207226/-the-treatment-of-the-patient-presenting-with-chronic-kidney-disease-ckd-and-fragility-fractures
#18
REVIEW
Andrea Giusti, Maria Fusaro
Fragility fractures occur in all stages of chronic kidney disease (CKD) due to low bone mineral density and poor bone quality (namely osteoporosis), as well as in CKD-mineral and bone disorders (CKD-MBD). As in postmenopausal women and older adults, the prompt identification of CKD subjects with a history of fragility fractures is crucial in order to implement strategies to reduce the risk of new fragility fractures and their consequences. The treatment of severe osteoporosis for patients with stages 1-3 CKD should not differ from patients without CKD, while clinical decisions and pharmacological treatments in subjects with stages 4-5/5D CKD differ greatly, being more tricky and challenging...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29201817/association-between-walking-and-low-back-pain-in-the-korean-population-a-cross-sectional-study
#19
Heesang Kim, Tae Jun Min, Si Hyun Kang, Don-Kyu Kim, Kyung Mook Seo, Sang Yoon Lee
Objective: To investigate if walking is independently associated with low back pain (LBP) in the general population. Methods: This cross-sectional study used public data from the Fourth and Fifth Korean National Health and Nutrition Examination Survey. Subjects included 5,982 community-dwelling adults aged ≥50 years. Presence of current LBP was defined as LBP for 1 month or more in the past 3 months. Walking was measured as total walking duration for the past week and subjects were divided into four quartiles...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29197959/fractures-frequently-occur-in-older-cancer-patients-the-md-anderson-cancer-center-experience
#20
Beatrice J Edwards, Ming Sun, Xiaotao Zhang, Holly M Holmes, Juhee Song, Peter Khalil, Meghan Karuturi, Jay B Shah, Colin P Dinney, Robert F Gagel, Vicente Valero, Richard E Champlin, Debasish Tripathy, William A Murphy
PURPOSE AND INTRODUCTION: A growing number of cancer patients are older adults aged 65 years and older. Patients with cancer are at increased risk for developing osteoporosis, falls, and fractures. We sought to identify the incidence of fractures in older adults who underwent cancer care between January 2013 and December 2015. METHODS: A comprehensive geriatric assessment was performed, and bone densitometry was measured at baseline, with a 2-year follow-up. RESULTS: In this study, among 304 patients with gastrointestinal, urologic, breast, lung, and gynecologic cancers we evaluated, and who completed the bone density testing (n = 199), 80% had osteoporosis or low bone mass (osteopenia)...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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