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Polymethylmethacrylate dialyzer

D Harada, K Matsuda, T Moriguchi, N Harii, J Goto, M Yanagisawa, H Sugawara, J Takamino, T Yoshino, Y Hasebe
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Kinuyo Sodemoto, Junya Yamahana, Takeshi Echigo, Chihiro Nishijima, Yuka Shimada, Makoto Inaoki
A 75-year-old Japanese man presented with pruritic blisters and macules on his trunk and extremities. He had been on hemodialysis for 4 years because of chronic renal failure, and in recent months, a polymethylmethacrylate membrane had been used for dialysis. After a change in dialysis membrane to a cellulose triacetate membrane, pruritic tense blisters developed on the extremities in combination with marked blood eosinophilia. Physical examination showed erythematous macules and tense blisters on the trunk and extremities...
April 2014: Hemodialysis International
P Fabbrini, S Sirtori, E Casiraghi, F Pieruzzi, S Genovesi, D Corti, R Brivio, G Gregorini, G Como, M L Carati, M R Viganò, A Stella
INTRODUCTION: Polymethylmethacrylate (PMMA) membranes can adsorb a wide variety of uremic toxins including serum free light chains (sFLC). However, limited data are available regarding the clinical use of PMMA in multiple myeloma patients and its maximum adsorption capacity in this setting. AIM: This study aimed to measure the capacity of PMMA to adsorb sFLC and identify strategies to improve its efficiency in clinical practice. METHODS: Ten patients with dialysis-dependent renal failure and high levels of sFLC were included in the study...
2013: Blood Purification
Tugce Goeksel, Wenhao Xie, Maria Ritzerfeld, Stefan Heidenreich, Helmut Mann
Prurigo nodularis is a skin disease with unknown origin which is frequent in patients on maintenance renal replacement therapy. Here, we report a patient who was dialyzed for more than 10 years with different dialyzers using different dialyzer membranes. Each time when the patient was switched to a polymethylmethacrylate membrane (Filtryzer BK-1.6P), itching and skin lesions disappeared completely. This effect could be verified three times.
2013: Blood Purification
E Duranti, D Duranti
AIM: Most chronic uremic patients undergoing dialysis show a diminished antibody response to anti-hepatitis B vaccination (anti-HBv) and at this regard high sCD40 serum levels seem to inhibit the immunocompetent response. A simple and feasible technique for removing soluble sCD40 by adsorption is standard bicarbonate dialysis performed by polymethylmethacrylate (PMMA) dialyzers able to remove serum high molecular weight toxins. Aim of the study was to assess whether PMMA dialyzers could enhance the long-term response to anti-HBv in non-responder (NR) ESRD patients...
December 2011: Minerva Medica
Kenichi Matsuda, Takeshi Moriguchi, Norikazu Harii, Masahiko Yanagisawa, Daiki Harada, Hisanori Sugawara
The aim of this study was to investigate whether continuous hemodiafiltration (CHDF) with a high-performance membrane dialyzer made of polymethylmethacrylate (PMMA-CHDF) in the treatment of septic shock patients with acute renal failure (ARF) is clinically relevant. 30 patients were treated with PMMA-CHDF. 13 patients treated with CHDF used a hemofilter made of polyacrylonitrile membrane (PAN-CHDF). Systolic blood pressure significantly increased in the PMMA-CHDF group following 24 h of treatment (p < 0...
2011: Contributions to Nephrology
Osamu Nishida, Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Miho Yumoto, Yasuyo Shimomura, Kazuhiro Moriyama
Sustained high-efficiency daily diafiltration using a mediator-adsorbing membrane (SHEDD-fA) is an effective, intensive modality for sepsis treatment. Here we describe the effectiveness of SHEDD-fA, which makes the best use of three principles: dialysis, filtration and adsorption, for mediator removal in the treatment of severe sepsis. SHEDD-fA was initiated after adequate fluid resuscitation and catecholamine support had been provided. A large (2.1 m(2)) polymethylmethacrylate membrane dialyzer was placed in the blood circuit...
2011: Contributions to Nephrology
Yoshitada Sakai
Forty years have passed since the polymethylmethacrylate (PMMA) membrane was first developed. This article reviews its history and explains its longevity. The membrane was developed through application of a stereocomplex phenomenon that is observed upon mixture of isotactic and syndiotactic PMMA polymers. Filtryzer(TM) B1 and B2 were approved in Japan in 1977. B1 was the pioneer high-performance membrane model and B2 was a model that simulated a low-flux cellulosic membrane. The development of B1 led to the development of the dialysis machine with an ultrafiltration rate (UFR)-controlling function because the UFR of B1 was too high to control using transmembrane pressure control...
2011: Contributions to Nephrology
Dong-Liang Zhang, Jing Liu, Wen-Ying Cui, Dan-Ying Ji, Yue Zhang, Wen-Hu Liu
BACKGROUND: Following the introduction of modified cellulosic and then synthetic membrane dialyzers, it was realized that the dialyzer bio-incompatibility depends on the membrane composition. We designed a prospective, randomized, cohort study of 6 months to determine several parameters of biocompatibility in maintenance hemodialysis (MHD) patients treated with four different membrane dialyzers. METHODS: There were 60 MHD patients enrolled in the study. In baseline, synthetic low-flux dialyzer, polysulfone (PS) membrane was used in all patients for at least 3 months...
2011: Renal Failure
Akihiro C Yamashita, Narumi Tomisawa
Selecting dialyzers is more important for blood purification in critical care because other therapeutic options (especially amount of dialysate) are usually limited. Adsorption is a major mechanism of removing toxic substances from patients in these treatments. Several commercial dialyzers designed for acute blood purification therapy were investigated by performing aqueous ultrafiltration experiments to demonstrate the adsorptive importance of membrane materials. Polymethylmethacrylate showed strong adsorptive characteristics to α-chymotripsinogen A (MW 25,000) but showed much less adsorptive characteristics to cytochrome C (MW 12,400)...
October 2010: Hemodialysis International
Akihiro C Yamashita, Kenji Sakurai
Commercial dialyzers were investigated both in vivo and in vitro for a better selection of dialyzers for hemodiafiltration (HDF) therapy. In in vivo online HDF, since a reduction rate of α(1)-microglobulin (α(1)-MG) was determined by the amount of albumin loss regardless of blood flow rate (Q(B)), ultrafiltration rate (Q(F)), and the performance of dialyzer, there is no preference for choice of dialyzers to remove α(1)-MG except for albumin sieving. It was clinically verified that albumin leakage mainly occurred in the first 60 min of treatment even in HD with a polysulfone dialyzer...
2011: Contributions to Nephrology
Akihiro C Yamashita, Narumi Tomisawa
Since therapeutic conditions, especially the amount of dialysate, are usually limited in continuous renal replacement therapy (CRRT), selecting an appropriate membrane is more crucial than that in chronic hemodialysis. Under such circumstances, the use of a membrane with adsorption is expected to remove a larger amount of target substances in CRRT. Five commercial dialyzers were investigated to demonstrate the importance of membrane characteristics. The adsorptive characteristics of polymethylmethacrylate (PMMA) membrane were relatively low for cytochrome c (MW 12,400), very strong for alpha-chymotrypsinogen A (MW 25,000) and relatively strong for albumin (MW 66,000), which may be understood that the adsorption in PMMA has the optimal molecular size...
2010: Contributions to Nephrology
Narumi Tomisawa, Akihiro C Yamashita
Polymethylmethacrylate (PMMA) membrane is the first synthetic polymeric hollow fiber used in dialyzers that is known to adsorb beta(2)-microglobulin. Polyester polymer alloy (PEPA), a blend of two polymers, i.e., polyarylate and polyethersulfone, is another dialysis membrane material with adsorption characteristics. In this study, the adsorption and permeation characteristics of BG-1.6PQ (PMMA) and FLX-15GW (PEPA) dialyzers were investigated by performing ultrafiltration experiments using chymotrypsinogen (molecular weight 25,000) and albumin (molecular weight 66,000) as test solutes...
2009: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Akihiro C Yamashita, Narumi Tomisawa
Choosing dialyzers is more important in blood purification in critical care because therapeutic conditions (especially the amount of dialysate) are usually limited. Then, adsorption is the third major mechanism of removing toxic substances from patients in these treatments. Several commercial dialyzers designed for acute blood purification therapy were investigated by performing aqueous ultrafiltration experiments to demonstrate the importance of the membrane materials. Polymethylmethacrylate (PMMA) showed strong adsorptive characteristics to alpha-chymotripsinogen A (MW 25,000) but showed much less adsorptive characteristics to cytochrome C (MW 12,400)...
February 2009: Transfusion and Apheresis Science
M Abe, K Okada, T Maruyama, A Inoshita, K Ikeda, E Uto, F Kikuchi, K Matsumoto
AIM: Changes in plasma immunoreactive insulin (IRI) and connecting-peptide immunoreactivity (CPR) concentrations during hemodialysis (HD) were evaluated in diabetic HD patients with 3 different high-flux membranes. The removal properties of the membranes were compared. METHOD: In this prospective controlled study, 15 stable diabetic patients on HD were randomly selected for 6 HD sessions with 3 different membranes: polysulfone (PS), cellulose triacetate (CTA), and polymethylmethacrylate (PMMA)...
October 2008: International Journal of Artificial Organs
Masanori Abe, Kazuyoshi Okada, Koichi Matsumoto
Alterations in plasma insulin and C-peptide concentrations following hemodialysis were evaluated using five types of dialyzer, which made of polysulphone, polyethersulfone, cellulose triacetate, polymethylmethacrylate, and polyester-polymer alloy, in diabetic patients. Plasma insulin and C-peptide were cleared by hemodialysis; their clearance rates and reduction rates differed across dialyzer types.
October 2008: Diabetes Research and Clinical Practice
Hsin-Hung Lin, Yao-Lung Liu, Jiung-Hsiun Liu, Che-Yi Chou, Ya-Fei Yang, Huey-Liang Kuo, Chiu-Ching Huang
Uremic pruritus is one of the common complications in long-term dialysis patients. Recently, researchers reported that immunohypothesis with high serum level of cytokines could be the cause of uremic pruritus. Polymethylmethacrylate (PMMA) artificial kidney (AK) has been reported to adsorb more serum cytokines than other high-flux AKs. In July 2006, 30 patients with severe uremic pruritus from 300 chronic hemodialysis (HD) patients in a single center entered this prospective study. Their dialyzers were changed to PMMA AK for 4 weeks...
June 2008: Artificial Organs
Nicola Tessitore, Annunziata Lapolla, Nadia Concetta Aricò, Albino Poli, Linda Gammaro, Antonella Bassi, Valeria Bedogna, Angela Corgnati, Rachele Reitano, Domenico Fedele, Antonio Lupo
BACKGROUND: Advanced glycation end-products (AGEs) are now considered to contribute to the middle molecule toxicity of uremia and, because they are not cleared by conventional low-flux hemodialysis, alternative strategies are needed to improve their removal. METHODS: In a prospective cross-over trial involving 18 adult chronic hemodialysis subjects, we evaluated the intradialytic removal and the long-term effect on predialysis levels of Protein-bound (PBPe) and Free (FPe) pentosidine by high-pore, protein-leaking BK-F Polymethylmethacrylate-based hemodialysis (BK-F-HD), by comparing it to hemodialysis using low-flux dialyzers (LF-HD)...
September 2004: Journal of Nephrology
Francesco Galli, Serena Benedetti, Umberto Buoncristiani, Marta Piroddi, Carmela Conte, Franco Canestrari, Emanuela Buoncristiani, Ardesio Floridi
BACKGROUND: Hyperhomocysteinemia is a well-recognized independent risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients. Since homocysteine (Hcy) largely binds to serum proteins (80 to 90%), in this study we investigated the possibility that polymethylmethacrylate (PMMA)-based protein-leaking dialyzers could reduce total plasma Hcy (tHcy) levels in ESRD patients. METHODS: Two matched groups of patients (N = 13) showing mild to intermediate hyperhomocysteinemia on standard hemodialysis (HD) with conventional non-protein-leaking dialyzers were included...
August 2003: Kidney International
Sabine Schmaldienst, André Oberpichler, Harald Tschesche, Walter H Hörl
Degranulation of polymorphonuclear leukocytes (PMNL) occurs during extracorporeal circulation. A degranulation-inhibiting protein identical to angiogenin was recently isolated from high-flux dialyzer ultrafiltrate. This protein inhibits the release of lactoferrin and metalloproteinases from PMNL in vitro. In the present study, we investigated end-stage renal disease patients undergoing regular hemodialysis treatment with either high-flux dialyzers (n = 51) or low-flux dialyzers (n = 44), and chronically uremic patients undergoing hemodiafiltration (n = 30)...
2003: Kidney & Blood Pressure Research
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