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https://www.readbyqxmd.com/read/29685874/impact-of-oral-side-effects-from-conditioning-therapy-before-hematopoietic-stem-cell-transplantation-protocol-for-a-multicenter-study
#1
Michael T Brennan, Bengt Hasséus, Allan J Hovan, Judith E Raber-Durlacher, Nicole Ma Blijlevens, Marie-Charlotte Huysmans, Karin Garming Legert, Jan-Erik Johansson, Charity G Moore, Inger von Bültzingslöwen
BACKGROUND: The oral cavity is a common site of complications related to the cytotoxic effect of high-dose chemotherapy and radiation therapy. Considering our limited understanding of the burden of illness in the oral cavity from various cytotoxic therapies, it is difficult to produce evidence-based, preventive and management protocols. A prospective multicenter study is necessary to collect data on the burden of illness from various cytotoxic regimens. OBJECTIVE: The objectives of this prospective international observational multicenter study in hematopoietic stem cell transplant (HSCT) patients are to establish the nature, incidence and temporal relationship of oral complications related to conditioning regimens (chemotherapy with or without total body irradiation), stem cell transplantation and the immunologic reactions (mainly graft-vs-host-disease) that may follow, and to determine what subjective and objective oral complications related to treatment can predict negative clinical and economic outcomes and reduced quality of life...
April 23, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29684249/standard-head-down-tilt-versus-modified-without-head-down-tilt-postural-drainage-in-infants-and-young-children-with-cystic-fibrosis
#2
REVIEW
Diana A Freitas, Gabriela Ss Chaves, Thayla A Santino, Cibele Td Ribeiro, Fernando Al Dias, Ricardo O Guerra, Karla Mpp Mendonça
BACKGROUND: Postural drainage is used primarily in infants with cystic fibrosis from diagnosis up to the moment when they are mature enough to actively participate in self-administered treatments. However, there is a risk of gastroesophageal reflux associated with this technique.This is an update of a review published in 2015. OBJECTIVES: To compare the effects of standard postural drainage (15º to 45º head-down tilt) with modified postural drainage (15º to 30º head-up tilt) with regard to gastroesophageal reflux in infants and young children up to six years old with cystic fibrosis in terms of safety and efficacy...
March 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29683734/six-year-review-of-traumatic-brain-injury-in-a-regional-trauma-unit-demographics-contributing-factors-and-service-provision-in-ireland
#3
Patrick W Owens, Noel P Lynch, Donal P O'Leary, Aoife J Lowery, Michael J Kerin
BACKGROUND: Traumatic brain injury (TBI) represents a significant burden of care for acute surgical services, particularly in the absence of on-site neurosurgical cover or sufficient post-acute rehabilitation facilities. We examine factors contributing to TBI, prolonged lengths of stay (LoS) and implications for hospital resources. Long-term outcomes are assessed. METHODS: This is a retrospective cohort study of patients admitted to a regional trauma unit with TBI from 2008 to 2013...
April 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29678895/healthcare-utilization-after-acute-kidney-injury-in-the-pediatric-intensive-care-unit
#4
Erin Hessey, Geneviève Morissette, Jacques Lacroix, Sylvie Perreault, Susan Samuel, Marc Dorais, Véronique Phan, Philippe Jouvet, Jean-Philippe Lafrance, Jacques LeLorier, Ana Palijan, Michael Pizzi, Louise Roy, Michael Zappitelli
BACKGROUND AND OBJECTIVES: Little is known about the long-term burden of AKI in the pediatric intensive care unit. We aim to evaluate if pediatric AKI is associated with higher health service use post-hospital discharge. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This is a retrospective cohort study of children (≤18 years old) admitted to two tertiary centers in Montreal, Canada. Only the first admission per patient was included. AKI was defined in two ways: serum creatinine alone or serum creatinine and/or urine output...
April 20, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29678716/surgical-management-of-medial-tentorial-meningioma-falcotentorial-and-torcular
#5
Andrea Talacchi, Antonio Biroli, Aurel Hasanbelliu, Francesca Locatelli
BACKGROUND: Falcotentorial meningiomas (FTM) stand out for their rarity, inconsistent definition, and surgical complexity. It is appropriate to deal with them in the context of medial tentorial meningiomas (MTM). METHODS: Clinical and radiological characteristics of MTM, comprising the typical features of FTM and tentorial meningioma (TM) along with surgical management, short- and long-term outcomes, are reported . RESULTS: FTM (n=16) were typically supratentorial, large, edematous tumors that caused mainly headache and hemianopia; TM (n=12) were infratentorial, smaller not edematous tumors that caused mainly headache and gait ataxia...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678279/the-psychiatric-consequences-of-cannabinoids
#6
Joao P De Aquino, Mohamed Sherif, Rajiv Radhakrishnan, John D Cahill, Mohini Ranganathan, Deepak C D'Souza
With rising rates of cannabis use in the general population and an increasing number of US states legalizing both recreational and medical cannabis use, it is important to be informed about the adverse consequences of cannabinoids. This Commentary provides an overview of the psychiatric effects of plant-based and synthetic cannabinoids, differentiating acute effects from effects associated with persistent use. Cannabinoids produce multiphasic and dose-dependent effects on anxiety, mood, and perception, in addition to impairing cognition and psychomotor function...
April 17, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29673881/long-term-outcome-in-extracranial-intracranial-bypass-surgery-for-severe-steno-occlusive-disease-of-intracranial-internal-carotid-or-middle-cerebral-artery
#7
Kok Ann Colin Teo, Tseng Tsai Yeo, Vijay K Sharma
OBJECTIVES: We report the long-term outcome and rates of recurrent cerebral ischemic events in our cohort of carefully selected patients after STA-MCA bypass for severe steno-occlusive disease of intracranial ICA or MCA with exhausted cerebral vasodilatory reserve. PATIENTS AND METHODS: In this retrospective study, we reviewed the hospital records for all patients who underwent direct superficial temporal artery-middle cerebral artery bypass surgery at our institution from January 2010 to August 2017...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29671109/the-use-of-start-back-screening-tool-in-emergency-departments-for-patients-with-acute-low-back-pain-a-prospective-inception-cohort-study
#8
Flávia Cordeiro Medeiros, Leonardo Oliveira Pena Costa, Indiara Soares Oliveira, Renan Kendy Oshima, Lucíola Cunha Menezes Costa
PURPOSE: (1) To analyse the clinical utility of the STarT Back Screening Tool (SBST) in emergency departments by describing changes in classification over time and; (2) to identify what would be the best time to use the SBST to predict long-term clinical outcomes in patients with acute nonspecific low back pain (LBP) seeking emergency care. METHODS: A 6 months prospective inception cohort study was conducted. 200 participants with LBP seeking emergency medical treatment were included...
April 18, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29667477/return-to-work-after-severe-traumatic-brain-injury-a-national-study-with-a-one-year-follow-up-of-neurocognitive-and-behavioural-outcomes
#9
Solrun Sigurdardottir, Nada Andelic, Eike Wehling, Audny Anke, Toril Skandsen, Oyvor Oistensen Holthe, Unn Sollid Manskow, Cecilie Roe
The objectives were to investigate the frequency of return-to-work (RTW) one year after severe traumatic brain injury (sTBI: Glasgow Coma Scale, GCS 3-8) and to identify which demographic and injury-related characteristics and neurocognitive factors are associated with RTW. This study is part of a prospective national study on sTBI conducted in all four Norwegian Trauma Referral Centres, including patients aged >15 years over a period of three years (n = 378). For the purpose of this study, only pre-employed individuals of working age (16 to 67 years) were investigated for RTW (n = 143), and of these, 104 participants underwent neuropsychological testing...
April 18, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#10
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29664815/long-term-posttraumatic-survival-of-spinal-fracture-patients-in-northern-finland
#11
Ville Niemi-Nikkola, Nelli Saijets, Henrikka Ylipoussu, Pietari Kinnunen, Juha Pesälä, Pirkka Mäkelä, Markku Alen, Mauri Kallinen, Aki Vainionpää
STUDY DESIGN: A retrospective epidemiological study. OBJECTIVE: To reveal the long-term survival and causes of death after traumatic spinal fracture (TSF) and to determine the possible factors predicting death. SUMMARY OF BACKGROUND DATA: Increased mortality following osteoporotic spinal fracture has been represented in several studies. Earlier studies concerning mortality after TSF have focused on specific types of fractures, or else only the mortality of the acute phases has been documented...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29663553/rapid-evidence-assessment-of-approaches-to-community-neurological-nursing-care-for-people-with-neurological-conditions-post-discharge-from-acute-care-hospital
#12
REVIEW
Judith Dianne Pugh, Kathleen McCoy, Anne M Williams, Brenda Bentley, Leanne Monterosso
Neurological conditions represent leading causes of non-fatal burden of disease that will consume a large proportion of projected healthcare expenditure. Inconsistent access to integrated healthcare and other services for people with long-term neurological conditions stresses acute care services. The purpose of this rapid evidence assessment, conducted February-June 2016, was to review the evidence supporting community neurological nursing approaches for patients with neurological conditions post-discharge from acute care hospitals...
April 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29662959/quarter-century-management-of-chronic-ureteropelvic-junction-obstruction-in-a-solitary-kidney-with-a-ureteral-stent
#13
Garen Abedi, Roshan M Patel, Cyrus Lin, Ralph V Clayman
Background: The ureteral stent provides a conduit for urinary drainage from the kidney to the bladder and is integral to contemporary urologic practice. A ureteral stent is often utilized in acute conditions to prevent or overcome obstruction; however, in nonsurgical patients, because of disease or preference, a ureteral stent may be used as a last resort for long-term management of a stricture in lieu of a nephrostomy tube. This case highlights a patient whose chronic ureteral obstruction has been managed with an indwelling ureteral stent for 25 years; remarkably, stent exchanges are currently required only every 2 years...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29662303/the-effectiveness-of-long-term-course-of-sterimar-mn-nasal-spray-for-treatment-of-the-recurrence-rates-of-acute-allergic-rhinitis-in-patients-with-chronic-allergic-rhinitis
#14
Michele Grasso, Marco de Vincentiis, Griselda Agolli, Francesco Cilurzo, Raffaele Grasso
Background: The "cost of illness" of the acute allergic rhinitis (AR) episodes in patients with chronic AR is very high in terms of therapy and quality of life. AR represents a worldwide health problem; despite the fact that many standardized treatments have been proposed and used, the recurrence rate of acute rhinitis episodes in springtime is always higher. Materials and methods: Sixty consecutive patients (13 F and 17 M in group A, 15 F and 15 M in group B; p =0...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29661626/influence-of-an-independent-quarterly-audit-on-publicly-reported-vancomycin-resistant-enterocococi-bacteremia-data-in-ontario-canada
#15
Chatura Prematunge, Michelle E Policarpio, Jennie Johnstone, Kwaku Adomako, Emily Nadolny, Freda Lam, Ye Li, Kevin A Brown, Gary Garber
BACKGROUND: All Ontario hospitals are mandated to self-report vancomycin-resistant enterocococi (VRE) bacteremias to Ontario's Ministry of Health and Long-term Care for public reporting purposes. Independent quarterly audits of publicly reported VRE bacteremias between September 2013 and June 2015 were carried out by Public Health Ontario. VRE bacteremia case-reporting errors between January 2009 and August 2013 were identified by a single retrospective audit. METHODS: Employing a quasiexperimental pre-post study design, the relative risk of VRE bacteremia reporting errors before and after quarterly audits were modeled using Poisson regression adjusting for hospital type, case counts reported to the Ministry of Health and Long-term Care, and autocorrelation via generalized estimating equation...
April 13, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29660743/-rehabilitation-after-multiple-trauma
#16
Stefan Simmel
Many polytrauma patients report significant long-term impairments to their physical and mental health, resulting in a reduction of their quality of life. In addition to the obvious physical accident sequences, psychological influences and the individual context factors pose special challenges to the rehabilitation team and the infrastructure of the facility. Professional reintegration and chronic pain are particularly common problems in the trauma rehabilitation. The central task of rehabilitation after accidents is the restoration or substantial improvement of the functional health and thus the reintegration into the social and professional environment...
April 2018: Die Rehabilitation
https://www.readbyqxmd.com/read/29658461/-monitoring-of-kidney-injury-in-preterm-infants
#17
Rong Zhang, Wen-Bin Dong
Acute kidney injury (AKI) is a common complication in the neonatal intensive care unit that causes a high mortality of preterm infants and various chronic kidney diseases in adulthood. Preterm infants have immature development of the kidneys at birth. The kidneys continue to develop within a specific time window after birth. However, due to various factors during pregnancy and after birth, preterm infants tend to develop AKI. At present, serum creatinine and urine volume are used for the assessment of kidney injury, and their early sensitivity and specificity have attracted increasing attention...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29658295/an-assessment-of-the-impact-of-just-culture-on-quality-and-safety-in-us-hospitals
#18
Marc T Edwards
In pursuit of high reliability, numerous organizations have promoted Just Culture, but its impact has never been assessed. This report combines data from a longitudinal survey-based study of clinical peer review practices in a cohort of 457 acute care hospitals with 43 measures from the Hospital Compare database and interprets them in relation to the long-term trends of Agency for Healthcare Research and Quality (AHRQ) data on the Hospital Survey of Patient Safety Culture. In all, 211 of 270 respondents (79%) indicated that their hospital has adopted Just Culture...
April 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29656802/impact-on-the-brain-of-the-inflammatory-response-to-surgery
#19
Sarah Saxena, Mervyn Maze
The brain is both the orchestrator as well as the target of the innate immune system's response to the aseptic trauma of surgery. When trauma-induced inflammation is not appropriately regulated persistent neuro-inflammation interferes with the synaptic plasticity that underlies the learning and memory aspects of cognition. The complications that ensue, include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) at two poles of a constellation that is now termed perioperative neurocognitive disorders...
April 12, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29656693/the-effect-of-first-clinical-assignments-on-prelicensure-nursing-students-attitudes-toward-older-people-an-observational-study
#20
Susan Larea Hovey, Mary J Dyck, MyoungJin Kim, Cynthia Reese
BACKGROUND: With the global population growth of older people, health care needs nurses interested in caring for this population. Studies have found a relationship between attitudes toward older people and career choices. AIM: The aim of this study was to determine the effect first clinical experiences had on nursing students' attitudes toward older people. DESIGN/METHOD: Using an observational research design, first-semester nursing students (n = 53) from the United States were assigned to one of two groups based on sequencing of clinical assignments...
April 16, 2018: Contemporary Nurse
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