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https://www.readbyqxmd.com/read/29784598/a-novel-digital-method-to-assess-air-space-loss-associated-with-acute-lung-injury-in-experimental-acute-pancreatitis
#1
R Mukherjee, L Wen, X Zhang, P Bhattacharya, W Huang, R Sutton
BACKGROUND/OBJECTIVES: Respiratory dysfunction and/or failure from acute lung injury (ALI) are common in acute pancreatitis (AP), but assessment of ALI in experimental AP has lacked standardisation. METHODS: A range of experimental AP models induced in C57BL/6 mice with corresponding controls (n = 6/group). Full double lung or right lung specimens were taken for histopathological assessment and slides analysed by a pre-set pipeline using Aperio Scanner (Leica), ImageJ software and CellProfiler software...
May 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29766934/spectrum-of-metastatic-neoplasms-of-the-brain-a-clinicopathological-study-in-a-tertiary-care-cancer-centre
#2
Smrita Singh, Usha Amirtham, Chennagiri S Premalata, Kuntegowdanahalli C Lakshmaiah, Lokesh Viswanath, Rekha V Kumar
Background: While brain metastases (BM) are the most common causes of neurologic disorders in patients with known systemic malignancies, they can often be the initial manifestations of an undetected primary elsewhere. BM are major causes of morbidity and mortality in cancer patients. Aims: We describe a mixed population (data from both retrospective and prospective collection) having a BM from a solid tumor. We report the percentage distribution of the most frequent types of BM, confirming the data published in the literature...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29755636/microfluidic-chip-for-non-invasive-analysis-of-tumor-cells-interaction-with-anti-cancer-drug-doxorubicin-by-afm-and-raman-spectroscopy
#3
Han Zhang, Lifu Xiao, Qifei Li, Xiaojun Qi, Anhong Zhou
Raman spectroscopy has been playing an increasingly significant role for cell classification. Here, we introduce a novel microfluidic chip for non-invasive Raman cell natural fingerprint collection. Traditional Raman spectroscopy measurement of the cells grown in a Polydimethylsiloxane (PDMS) based microfluidic device suffers from the background noise from the substrate materials of PDMS when intended to apply as an in vitro cell assay. To overcome this disadvantage, the current device is designed with a middle layer of PDMS layer sandwiched by two MgF2 slides which minimize the PDMS background signal in Raman measurement...
March 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29736283/chronic-pulmonary-silicone-embolism-from-breast-augmentation-is-not-a-common-finding-in-explanted-lungs
#4
Jarmanjeet Singh, Hanine Inaty, Sanjay Mukhopadhyay, Atul C Mehta
Objective: Acute pulmonary silicone embolism (APSE) related to subcutaneous silicone injections is a well-known entity. Recently, a few cases of pathologically confirmed chronic pulmonary silicone embolism (CPSE) from breast implants have been reported. The prevalence of CPSE in women with breast augmentation is unknown. This study was done to determine the prevalence of CPSE in female lung transplant recipients with a history of breast augmentation and to determine whether breast augmentation plays a role in chronic lung diseases requiring lung transplantation...
2018: Pulmonary Medicine
https://www.readbyqxmd.com/read/29723687/new-insights-on-diagnostic-reproducibility-of-biphasic-mesotheliomas-a-multi-institutional-evaluation-by-the-international-mesothelioma-panel-from-the-mesopath-reference-center
#5
F Galateau Salle, N Le Stang, A G Nicholson, D Pissaloux, A Churg, S Klebe, V Roggli, H Tazelaar, J M Vignaud, R Attanoos, M B Beasley, H Begueret, F Capron, L Chirieac, M C Copin, S Dacic, C Danel, A Foulet-Roge, A Gibbs, S Giusiano-Courcambeck, K Hiroshima, V Hofman, A Husain, K Kerr, A Marchevsky, K Nabeshima, J M Picquenot, I Rouquette, C Sagan, J Sauter, F Thivolet, W D Travis, M S Tsao, B Weynand, F Damiola, A Scherpereel, J C Pairon, S Lantuejoul, V Rusch, N Girard
BACKGROUND: The 2015 WHO classified malignant mesothelioma into epithelioid [EM], biphasic [BM] and sarcomatoid [SM] for prognostic relevance and treatment decisions. The survival of BM is suspected to correlate with the amount of the sarcomatoid component. The criteria for a sarcomatoid component and the interobserver variability between pathologists for identifying this component are not well described. In ambiguous cases, a "transitional"[TM] subtype has been proposed but was not accepted as a specific subtype in the 2015 WHO...
April 30, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29696124/diagnostic-value-of-sonography-for-confirmation-of-endotracheal-intubation-in-the-emergency-department
#6
Farzad Rahmani, Zahra Parsian, Kavous Shahsavarinia, Mahboob Pouraghaei, Sohrab Negargar, Robab Mehdizadeh Esfanjani, Hassan Soleimanpour
Background: Intubation and maintaining airway are crucial in the management of critically ill patients in the emergency department. Correct tracheal intubation should be confirmed by the physician, otherwise oesophageal intubation could lead to hypoxia with detrimental consequences and even death. Sonography can be used to determine proper placement of the tracheal tube. Methods: In this study, 75 patients, with an indication of intubation and age older than 18 years entered the study...
December 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29689594/does-the-addition-of-m-mode-to-b-mode-ultrasound-increase-the-accuracy-of-identification-of-lung-sliding-in-traumatic-pneumothoraces
#7
Jacob Avila, Ben Smith, Therese Mead, Duane Jurma, Matthew Dawson, Michael Mallin, Adam Dugan
OBJECTIVES: It is unknown whether the addition of M-mode to B-mode ultrasound (US) has any effect on the overall accuracy of interpretation of lung sliding in the evaluation of a pneumothorax by emergency physicians. This study aimed to determine what effect, if any, this addition has on US interpretation by emergency physicians of varying training levels. METHODS: One hundred forty emergency physicians were randomized via online software to receive a quiz with B-mode clips alone or B-mode with corresponding M-mode images and asked to identify the presence or absence of lung sliding...
April 24, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29682792/rapid-assessment-of-pulmonary-gas-transport-with-hyperpolarized-129xe-mri-using-a-3d-radial-double-golden-means-acquisition-with-variable-flip-angles
#8
Kai Ruppert, Faraz Amzajerdian, Hooman Hamedani, Yi Xin, Luis Loza, Tahmina Achekzai, Ian F Duncan, Harrilla Profka, Sarmad Siddiqui, Mehrdad Pourfathi, Maurizio F Cereda, Stephen Kadlecek, Rahim R Rizi
PURPOSE: To demonstrate the feasibility of using a 3D radial double golden-means acquisition with variable flip angles to monitor pulmonary gas transport in a single breath hold with hyperpolarized xenon-129 MRI. METHODS: Hyperpolarized xenon-129 MRI scans with interleaved gas-phase and dissolved-phase excitations were performed using a 3D radial double golden-means acquisition in mechanically ventilated rabbits. The flip angle was either held fixed at 15 ° or 5 °, or it was varied linearly in ascending or descending order between 5 ° and 15 ° over a sampling interval of 1000 spokes...
April 22, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29679518/new-insights-in-the-use-of-pleural-ultrasonography-for-diagnosis-and-treatment-of-pleural-disease
#9
Giampietro Marchetti, Sabrina Arondi, Francesca Baglivo, Sara Lonni, Federico Quadri, Alberto Valsecchi, Nicola Venturoli, Paolo Ceruti
The use of transthoracic ultrasound has acquired a wide consensus among respiratory physicians during the last few years. The developing of portable and easily available devices favorites patient's bedside evaluation. Transthoracic ultrasound provides rapid, real-time and low-cost diagnostic information, allowing image-guided chest interventions and reducing procedural risks. The different acoustic impedance between aerated and not aerated organs produces artifacts known as A lines, B lines, sliding sign, lung point, etc...
April 21, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29676358/frequency-distribution-and-immunomorphologic-characteristics-of-peripheral-t-cell-lymphoma-not-otherwise-specified-in-a-tertiary-care-center-in-southern-india
#10
Archana Lakshmanan, Deeksha Sikri, Sushama Patil, Ann Kurian, S Annapurneswari, Sheila Nair
Aims: In world literature, Peripheral T-cell lymphomas (PTCLs) constituted about 12% of non-Hodgkin's lymphomas (NHL) of which PTCL not otherwise specified (NOS) was the most common subtype. This study was undertaken to ascertain the frequency and to assess the morphologic and immunophenotypic characteristics of PTCL, NOS over a period of 5 years in a tertiary care referral center in Southern India. Materials and Methods: Slides and blocks of all PTCL, NOS were retrieved, and a detailed morphologic and immunophenotypic study using a wide panel of antibodies was done...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29667142/pulmonary-cement-embolism-is-not-associated-with-the-cause-of-death-in-a-post-mortem-cohort-of-cement-augmented-interventions-in-the-spine
#11
Sebastian Butscheidt, Tim Rolvien, Jakob Ritter, Axel Heinemann, Hermann Vogel, Michael Amling, Klaus Püschel
PURPOSE: Complications of cement-augmented interventions (e.g., kyphoplasty) in the spine include local cement leakage and pulmonary cement embolisms (PCE). This study was conducted to determine their extent in a unique post-mortem cohort. METHODS: Retrospective analysis of post-mortem whole-body CT scans and review of autopsy results in 29 consecutive cases with cement-augmented interventions in the spine. PCE findings were graded based on cement deposits: grade 0 (no PCE), grade 1 (1-3 PCE), grade 2 (4-6 PCE), and grade 3 (> 6 or branch-shaped PCE)...
April 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29662918/gifted-demons-deformable-image-registration-with-local-structure-preserving-regularization-using-supervoxels-for-liver-applications
#12
Bartłomiej W Papież, James M Franklin, Mattias P Heinrich, Fergus V Gleeson, Michael Brady, Julia A Schnabel
Deformable image registration, a key component of motion correction in medical imaging, needs to be efficient and provides plausible spatial transformations that reliably approximate biological aspects of complex human organ motion. Standard approaches, such as Demons registration, mostly use Gaussian regularization for organ motion, which, though computationally efficient, rule out their application to intrinsically more complex organ motions, such as sliding interfaces. We propose regularization of motion based on supervoxels, which provides an integrated discontinuity preserving prior for motions, such as sliding...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29643656/comparison-of-conventional-smear-and-liquid-based-cytology-preparation-in-diagnosis-of-lung-cancer-by-bronchial-wash-and-transbronchial-needle-aspiration
#13
Aasma Nalwa, Ritika Walia, Varsha Singh, Karan Madan, Sandeep Mathur, Venkateshwaran Iyer, Deepali Jain
Introduction: Liquid-based cytology (LBC), initially developed for screening gynecologic specimens, is now being used in nongynecologic aspiration and exfoliative specimens. In this study, the diagnostic yield and utility of thin-prep (TP) was compared with conventional preparations to ascertain its utility in improving the diagnosis of respiratory lesions. Materials and Methods: Bronchial washings (BW) and transbronchial needle aspirates (TBNA) (bronchoscopy/endobronchial ultrasound-guided) from 70 consecutive patients of mediastinal masses and endo/peribronchial growths were included...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29619581/approach-to-undifferentiated-dyspnea-in-emergency-department-aids-in-rapid-clinical-decision-making
#14
Siva Nageswara Rao Guttikonda, Kiran Vadapalli
BACKGROUND: Diagnosis and management of patients presenting with acute dyspnea is one of the major challenges for physicians in emergency department (ED). A correct diagnosis is frequently delayed and difficult to ascertain, and clinical uncertainty is common, explaining the need for rapid diagnosis and a management plan. The primary aim of our study is to assess a diagnostic strategy using multiorgan point of care ultrasonography (USG) to differentiate patients presenting with acute dyspnea to ED into different diagnostic categories for timely management in a resource-limited setting...
April 4, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29611210/interplay-effect-on-a-6-mv-flattening-filter-free-linear-accelerator-with-high-dose-rate-and-fast-multi-leaf-collimator-motion-treating-breast-and-lung-phantoms
#15
Tucker Netherton, Yuting Li, Paige Nitsch, Simona Shaitelman, Peter Balter, Song Gao, Ann Klopp, Manickam Muruganandham, Laurence Court
PURPOSE: Using a new linear accelerator with high dose rate (800 MU/min), fast MLC motions (5.0cm/s), fast gantry rotation (15sec/rotation), and 1cm wide MLCs, we aimed to quantify the effects of complexity, arc number, and fractionation on interplay for breast and lung treatments under target motion. METHODS: To study lung interplay, eight VMAT plans (one to six arcs) and four nine-field sliding-window IMRT plans varying in complexity were created. For the breast plans, four four-field sliding-window IMRT plans were created...
April 2, 2018: Medical Physics
https://www.readbyqxmd.com/read/29611055/the-more-the-micropapillary-pattern-in-stage-i-lung-adenocarcinoma-the-worse-the-prognosis-a-retrospective-study-on-digitalized-slides
#16
Tamás Zombori, Tibor Nyári, László Tiszlavicz, Regina Pálföldi, Edit Csada, Tibor Géczi, Aurél Ottlakán, Balázs Pécsy, Gábor Cserni, József Furák
Although the majority of lung adenocarcinomas show mixed pattern, only the predominant component is taken into account according to the novel classification. We evaluated the proportion of different patterns and their impact on overall survival (OS) and disease-free survival (DFS). Patterns were recorded according to predominance and their proportions were rated and calculated by objective area measuring on digitalized, annotated slides of resected stage I lung adenocarcinomas. Spearman's rank correlation, Kaplan-Meier models and the log rank test were used for statistical evaluation...
April 2, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29605371/an-approach-to-successful-slide-tracheoplasty-in-the-low-birth-weight-neonate-with-single-lung
#17
Matthew S Yong, Joanne Harrison, Robert G Berkowitz, Sarath Ranganathan, Igor E Konstantinov
The advent of the slide tracheoplasty technique and a multi-disciplinary approach has improved outcomes of congenital tracheal stenosis. However, tracheal surgery in younger patients with pulmonary malformations, especially low birth-weight neonates, has been associated with increased mortality. Patients with very low birth-weight, pulmonary malformations and prematurity may be palliated prior to definitive tracheal surgery due to the poor prognosis. We report a successful and unique approach of delaying tracheal reconstruction to allow growth and development in the premature, very low birth-weight neonate (1046g) with left lung agenesis...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29600975/highly-activated-carbon-enterosorbent-mediates-the-suppression-of-paraneoplastic-syndrome-associated-with-lewis-lung-carcinoma-in-mice
#18
V V Sarnatskaya, L Sakhno, L M Paziuk, L A Yushko, N K Rodionova, V N Maslenniy, A S Sidorenko, V Nikolaev
AIM: To investigate the effect of enterosorption on the development of paraneoplastic syndrome in mice with Lewis lung carcinoma (LLC). MATERIALS AND METHODS: The study was performed on male С57/ВL6 mice with transplanted LLC. As an enterosorbent, highly activated powder fraction of HSGD was administered per os daily at a dose of 0.625 g/kg for two weeks starting from the 7th day after tumor cell transplantation. Analysis of hemo- and myelograms, morphological alterations in vital organs, the activities of catalase and superoxide dismutase, biochemical analysis of blood and quantitative analysis of hydroperoxides, malonic dialdehyde, аdvanced oxidation protein products was carried out by standard methods after completing the course of enterosorption...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29556302/tumor-suppressor-candidate-3-a-novel-grading-tool-and-predictor-of-clinical-malignancy-in-human-gliomas
#19
Jing Yuan, Xinshuang Yu, Aihua Wang, Yan Li, Fengjun Liu, Yao Wang, Shanmei Sun, Xiuyang Bing, Yiming Liu, Juan Du
For several years, the cause of autosomal recessive mental retardation has been attributed to the deletion or mutation of a gene named tumor suppressor candidate 3 (TUSC3). Previous research has identified that TUSC3 is a potential tumor suppressor gene in oral epidermoid carcinoma, lung cancer and esophageal cancer. However, to the best of our knowledge, no previously published data has existed on the expression of TUSC3 in gliomas. The present study focused on the expression of TUSC3 in brain gliomas. Additionally, the present study sought to identify he association between TUSC3 expression and the typical clinical and pathological disease manifestations of gliomas...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29529386/cell-type-specific-quantification-of-telomere-length-and-dna-double-strand-breaks-in-individual-lung-cells-by-fluorescence-in-situ-hybridization-and-fluorescent-immunohistochemistry
#20
Aernoud A van Batenburg, Karin M Kazemier, Ton Peeters, Matthijs F M van Oosterhout, Joanne J van der Vis, Jan C Grutters, Roel Goldschmeding, Coline H M van Moorsel
Telomeres are small repetitive DNA sequences at the ends of chromosomes which act as a buffer in age-dependent DNA shortening. Insufficient telomere repeats will be recognized as double-strand breaks. Presently, it is becoming more evident that telomere attrition, whether or not caused by mutations in telomere maintenance genes, plays an important role in many inflammatory and age-associated diseases. In this report, a method to (semi)quantitatively assess telomere length and DNA double-strand breaks in formalin-fixed paraffin-embedded (FFPE) tissue is described...
March 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
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