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https://www.readbyqxmd.com/read/29779887/pulmonary-capillary-hemorrhage-induced-by-diagnostic-ultrasound-in-ventilated-rats
#1
Douglas L Miller, Zhihong Dong, Chunyan Dou, Krishnan Raghavendran
Pulmonary capillary hemorrhage (PCH) can be induced by diagnostic ultrasound-a potential safety issue. Anesthetized rats were intubated for intermittent positive-pressure ventilation (IPPV) with 0 end-expiratory pressure, +4 cm H2 O end-expiratory pressure (PEEP) and -4 cm H2 O end-expiratory pressure (NEEP). Rats were imaged at 7.6 MHz with a Philips HDI 5000 ultrasound machine. The output was low (mechanical index [MI] = 0.22) for aiming and then was raised for 5 min in 20 different exposure groups with n = 8...
May 17, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29778209/ovine-mannheimia-haemolytica-isolates-from-lungs-with-and-without-pneumonic-lesions-belong-to-similar-genotypes
#2
Andrés García-Alvarez, José Francisco Fernández-Garayzábal, Fernando Chaves, Chris Pinto, Dolores Cid
This study investigated the genetic characteristics of 121 ovine Mannheimia haemolytica isolates from lungs with (n = 75) and without pneumonic lesions (n = 46) using multilocus sequence typing (MLST), virulence-associated gene typing and pulsed-field gel electrophoresis (PFGE). Twelve STs were identified with most isolates (81%) belonged to ST16, ST28 and ST8. Analysis of the M. haemolytica MLST Database indicate a wide distribution of these genotypes in small ruminants, never reported in bovine isolates...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29776439/concurrence-of-symmetrical-peripheral-gangrene-and-venous-limb-gangrene-following-polytrauma-a-case-report
#3
Jih Huei Tan, Yuzaidi Mohamad, Chor Lip Henry Tan, Mahazir Kassim, Theodore E Warkentin
BACKGROUND: Symmetrical peripheral gangrene is characterized as acral (distal extremity) ischemic limb injury affecting two or more extremities, without large vessel obstruction, typically in a symmetrical fashion. Risk factors include hypotension, disseminated intravascular coagulation, and acute ischemic hepatitis ("shock liver"). In contrast, venous limb gangrene is characterized by acral ischemic injury occurring in a limb with deep vein thrombosis. Both symmetrical peripheral gangrene and venous limb gangrene present as acral limb ischemic necrosis despite presence of arterial pulses...
May 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29764965/effect-of-treat-to-target-strategies-aiming-at-remission-of-arterial-stiffness-in-early-rheumatoid-arthritis-a-randomized-controlled-study
#4
Lydia Ho-Pui Tam, Qing Shang, Edmund Kwok-Ming Li, Priscilla Ching-Han Wong, Kitty Yan Kwok, Emily Wai-Lin Kun, Isaac Cheuk-Wan Yim, Violet Ka-Lai Lee, Ronald Man-Lung Yip, Steve Hin-Ting Pang, Virginia Weng-Nga Lao, Queenie Wah-Yan Mak, Isaac Tsz-Ho Cheng, Xerox Sze-Lok Lau, Tena Ka-Yan Li, Tracy Yaner Zhu, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count Disease Activity Score (DAS28) remission (DAS28 < 2.6) in the prevention of arterial stiffness in patients with early rheumatoid arthritis (RA). METHODS: This was an open-label study in which 120 patients with early RA were randomized to receive 1 year of tight control treatment. Group 1 (n = 60) aimed to achieve SDAI ≤ 3...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29755808/the-role-of-duration-of-hyperbaric-oxygen-therapy-on-lung-injury-an-experimental-study-lung-injury-and-hyperbaric-oxygen-therapy
#5
Menduh Oruç, Bennur Esen, Maşuk Taylan, Yusuf Nergis, Atalay Şahin
OBJECTIVES: We aim to histopathologically analyze the effect of hyperbaric oxygen (HBO) therapy in the lung tissue. MATERIAL AND METHODS: A total of 21 rabbits were divided into three groups, with each containing seven rabbits. Group 1 was the control group. Group 2 underwent HBO of 3 atmosphere absolute (ATA) for 90 min/day for 7 days. In group 3, HBO at 3 ATA was administered 90 min/day for 28 days. Oxygen saturation (SpO2 ) was determined by pulse oximetry before and after administration of HBO...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29753165/diagnosis-of-egfr-exon21-l858r-point-mutation-as-lung-cancer-biomarker-by-electrochemical-dna-biosensor-based-on-reduced-graphene-oxide-functionalized-ordered-mesoporous-carbon-ni-oxytetracycline-metallopolymer-nanoparticles-modified-pencil-graphite-electrode
#6
Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh
In this present work we made a novel, fast, selective and sensitive electrochemical genobiosensor to detection of EGFR exon 21 point mutation based on two step electropolymerization of Ni(II)-oxytetracycline conducting metallopolymer nanoparticles (Ni-OTC NPs) on the surface of pencil graphite electrode (PGE) which was modified by reduced graphene oxide/carboxyl functionalized ordered mesoporous carbon (rGO/f-OMC) nanocomposite. ssDNA capture probe with amine groups at the5' end which applied as recognition element was immobilized on the rGO/f-OMC/PGE surface via the strong amide bond...
April 14, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29750170/electroporation-with-cisplatin-against-metastatic-pancreatic-cancer-in-vitro-study-on-human-primary-cell-culture
#7
Olga Michel, Julita Kulbacka, Jolanta Saczko, Justyna Mączyńska, Piotr Błasiak, Joanna Rossowska, Adam Rzechonek
Despite the rapid progression of cancer pharmacotherapy, the high drug resistance of pancreatic ductal adenocarcinoma (PDA) makes it one of the most lethal malignancies. Therefore, there are high expectations associated with experimental therapies, such as electrochemotherapy (ECT). This technique involves the application of short electric pulses to induce transitional permeabilization of the cellular membrane, thus enhancing drug molecules influx. The aim of the study was to investigate the influence of electroporation with cisplatin (CisEP) on the primary culture of human PDA cells from lung metastases-their survival and stress response...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29741919/efficacy-of-acupuncture-treatment-for-improving-the-respiratory-status-in-patients-receiving-prolonged-mechanical-ventilation-in-intensive-care-units-a-retrospective-observational-study
#8
Jun Matsumoto-Miyazaki, Hiroaki Ushikoshi, Kodai Suzuki, Nagisa Miyazaki, Takahide Nawa, Hideshi Okada, Shozo Yoshida, Ichijiro Murata, Shinji Ogura, Shinya Minatoguchi
BACKGROUND AND OBJECTIVE: Patients in critical care settings often require prolonged mechanical ventilation (MV) therapy and, occasionally, they cannot be weaned from MV. The authors evaluated the efficacy of acupuncture treatment for improving the respiratory status and promoting successful weaning from prolonged MV in patients at intensive care units (ICUs). DESIGN: Retrospective observational study. SETTING: Gifu University Hospital, Gifu, Japan...
May 9, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29721013/changes-in-hepatic-blood-flow-and-liver-function-during-closed-abdominal-hyperthermic-intraperitoneal-chemotherapy-following-cytoreduction-surgery
#9
Stéphanie Dupont, Eduardo R C Schiffer, Marion J White, John R A Diaper, Marc-Joseph Licker, Philippe C Masouyé
Background: The increase in intra-abdominal pressure (IAP) during closed abdominal hyperthermic intraperitoneal chemotherapy (HIPEC) leads to major haemodynamic changes and potential organ dysfunction. We investigated these effects on hepatic blood flow (HBF) and liver function in patients undergoing HIPEC following cytoreductive surgery and fluid management guided by dynamic preload indices. Methods: In this prospective observational clinical study including 15 consecutive patients, we evaluated HBF by transesophageal echocardiography and liver function by determination of the indocyanine green plasma disappearance rate (ICG-PDR)...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29719811/unusual-long-survival-despite-severe-lung-disease-of-a-child-with-biallelic-loss-of-function-mutations-in-abca-3
#10
P El Boustany, R Epaud, C Grosse, F Barriere, E Grimont-Rolland, A Carsin, J C Dubus
Homozygous or compound heterozygous for frameshift or nonsense mutations in the ATP-binding cassette transporter A3 (ABCA3) is associated with neonatal respiratory failure and death within the first year of life without lung transplantation. We report the case of a newborn baby girl who developed severe respiratory distress soon after birth. She was diagnosed with compound heterozygous frameshift mutation of the ABCA3 gene. Despite extensive treatment (intravenous corticosteroids pulse therapy, oral corticosteroids, azithromycin, and hydroxychloroquine), she developed chronic respiratory failure...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29695251/efficacy-and-mechanism-of-steep-pulse-irreversible-electroporation-technology-on-xenograft-model-of-nude-mice-a-preclinical-study
#11
Zuoqing Song, Xiaohong Xu, Minghui Liu, Jinghao Liu, Jun Chen, Chengxiang Li, Chenguo Yao, Qinghua Zhou
BACKGROUND: Steep pulse therapy can irreversible electrically brackdown of tumor membrance and cause cell death. In previous studies, we investigated the effect of steep pulsed electroporation on the killing of large cell lung cancer cell line L981- in vitro, and determined the best parameters for killing lung cancer cells by steep pulse technology. But the optimal parameters and the mechanisms of steep pulse irreversible electroporation technology on nude mouse tumor model are unclear...
April 25, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29688849/cryptococcoma-of-a-transplanted-kidney-in-a-patient-presenting-with-recurrent-urinary-tract-infection-a-case-report
#12
Albert Z Muranda, Ludolf Greeff, Mike M Sathekge, Thabo Lengano, Victor O L Karusseit
BACKGROUND: Cryptococcosis is an important opportunistic infection of organ transplant recipients. It is the third most common fungal infection of transplant patients and occurs especially in kidney recipients. Cryptococcus neoformans is a ubiquitous fungus which infects humans by inhalation of spores. C. gattii has more recently been recognised as a pathogen. Infection commonly is disseminated affecting mainly the central nervous system and the lungs. Cryptococcoma, a localised form of the disease, has been described in various organs...
April 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29684994/postoperative-infusion-of-a-low-dose-of-dexmedetomidine-reduces-intravenous-consumption-of-sufentanil-in-patient-controlled-analgesia
#13
Dae-Eun Kweon, Youngbin Koo, Seonyi Lee, Kumhee Chung, Sowoon Ahn, Chunghyun Park
Background: Combining adjunctive medications with patient-controlled analgesia (PCA) has been used to minimize opioid related side-effects. The aim of this study was to evaluate whether postoperative infusion of a sub-sedative dose of dexmedetomidine can reduce opioid consumption and opioid related side-effects. Methods: We selected 60 patients from 18 to 60 years old with an American Society of Anesthesiologists physical status of 1-2 who were scheduled for elective surgery...
April 24, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29673645/intranasal-delivery-of-adjuvant-free-peptide-nanofibers-elicits-resident-cd8-t-cell-responses
#14
Youhui Si, Yi Wen, Sean H Kelly, Anita S Chong, Joel H Collier
Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers have been investigated previously as platforms for vaccines and immunotherapies and have been shown to raise immune responses in the absence of exogenous adjuvants and without measurable inflammation. However, at present it has not been tested whether the immunogenicity of these materials extends to the intranasal route...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29671629/impaired-left-ventricular-filling-is-associated-with-decreased-pulse-oximetry-values
#15
Lene Gjelseth Dalbak, Henrik Schirmer, Jørund Straand, Ibrahimu Mdala, Ole Geir Solberg, Hasse Melbye
OBJECTIVES: The aim of this study was to investigate the association between echocardiographic measures of diastolic left ventricular dysfunction and decreased arterial oxyhaemoglobin saturation measured with pulse oximetry (SpO2 ). DESIGN: This is a cross-sectional population-based survey of Norwegian adults. Values obtained using echocardiography, pulse oximetry, and spirometry were included. The primary outcome was abnormal mitral Doppler inflow, defined as normal: E/A ratio 0...
April 19, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29670534/divergent-mitochondrial-antioxidant-activities-and-lung-alveolar-architecture-in-the-lungs-of-rats-and-mice-at-high-altitude
#16
Alexandra Jochmans-Lemoine, Susana Revollo, Gabriella Villalpando, Ibana Valverde, Marcelino Gonzales, Sofien Laouafa, Jorge Soliz, Vincent Joseph
Compared with mice, adult rats living at 3,600 m above sea level (SL-La Paz, Bolivia) have high hematocrit, signs of pulmonary hypertension, and low lung volume with reduced alveolar surface area. This phenotype is associated with chronic mountain sickness in humans living at high altitude (HA). We tested the hypothesis that this phenotype is associated with impaired gas exchange and oxidative stress in the lungs. We used rats and mice (3 months old) living at HA (La Paz) and SL (Quebec City, Canada) to measure arterial oxygen saturation under graded levels of hypoxia (by pulse oximetry), the alveolar surface area in lung slices and the activity of pro- (NADPH and xanthine oxidases-NOX and XO) and anti- (superoxide dismutase, and glutathione peroxidase-SOD and GPx) oxidant enzymes in cytosolic and mitochondrial lung protein extracts...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29661432/evaluation-of-lung-function-in-liver-transplant-candidates
#17
L Roque, A K Sankarankutty, O C Silva, E D Mente
INTRODUCTION: A wide variety of pulmonary conditions are found in cirrhotic patients and may compromise the pleura, diaphragm, parenchyma, and pulmonary vasculature, influencing the results of liver transplantation. OBJECTIVE: To evaluate the pulmonary function (lung capacities, volumes, and gasometric study) of patients with liver cirrhosis awaiting liver transplantation. PATIENTS AND METHODS: Cirrhotic patients, subdivided into 3 groups stratified by liver disease severity using the Child-Pugh-Turcotte score, were compared with a control group of healthy volunteers...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29657726/high-dose-steroid-therapy-for-acute-respiratory-distress-syndrome-lacking-common-risk-factors-predictors-of-outcome
#18
Yoshiaki Kinoshita, Hiroshi Ishii, Hisako Kushima, Kentaro Watanabe, Masaki Fujita
Aim: Acute respiratory distress syndrome (ARDS) is a life-threatening lung disease that usually occurs in patients with the underling risk factors that triggers lung inflammation. We sometimes encounter patients with ARDS lacking common risk factors. Recent studies have indicated the effectiveness of corticosteroids for this cohort. However, the characteristics of survivors with ARDS who lack common risk factors, and who received high-dose methylprednisolone pulse therapy (MPPT), are not known...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29656748/nivolumab-induced-severe-pancytopenia-in-a-patient-with-lung-adenocarcinoma
#19
Kentaro Tokumo, Takeshi Masuda, Takahiko Miyama, Shinichiro Miura, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Takashi Yoshida, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Severe leukopenia, thrombocytopenia, and bi-cytopenia due to nivolumab have been reported. In this report, we present the first case of nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma. A 56-year-old Japanese man with lung adenocarcinoma received nivolumab therapy as second-line treatment. After 3 cycles of this therapy, although computed tomography (CT) showed a reduced tumor size, laboratory findings revealed pancytopenia and a bone marrow biopsy showed a severely hypoplastic marrow...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29655805/metabolic-syndrome-positively-correlates-with-the-risks-of-atherosclerosis-and-diabetes-in-a-chinese-population
#20
Sung-Sheng Tsai, Yu-Sheng Lin, Szu-Tah Chen, Pao-Hsien Chu
BACKGROUND: Published studies seldom tested the weight of different waist circumference (WC) cut-off values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes, including cardiovascular disease and diabetes. METHODS: This is a Chinese population-based cross-sectional study screening subjects from a Health Examination Program since 1999 to 2015. The MetS identification and scores were determined either according to the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points...
April 12, 2018: European Journal of Internal Medicine
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