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https://www.readbyqxmd.com/read/27910005/doppler-images-of-intra-pulmonary-shunt-within-atelectasis-in-anesthetized-children
#1
Cecilia M Acosta, Gerardo Tusman, Mauro Costantini, Camila Echevarría, Sergio Pollioto, Diego Abrego, Fernando Suarez-Sipmann, Stephan H Böhm
BACKGROUND: Doppler images of pulmonary vessels in pulmonary diseases associated with subpleural consolidations have been described. Color Doppler easily identifies such vessels within consolidations while spectral Doppler analysis allows the differentiation between pulmonary and bronchial arteries. Thus, Doppler helps in diagnosing the nature of consolidations. To our knowledge, Doppler analysis of pulmonary vessels within anesthesia-induced atelectasis has never been described before...
December 2016: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/27906620/the-radiosensitizing-effect-of-fluorocyclopentenyl-cytosine-rx-3117-in-ovarian-and-lung-cancer-cell-lines
#2
Dzjemma Sarkisjan, Jaap van den Berg, Evelyn Smit, Young B Lee, Deog J Kim, Godefridus J Peters
RX-3117 (fluorocyclopentenyl-cytosine) is a novel cytidine analog currently being evaluated in a Phase Ib clinical trial in cancer patients with solid tumors. The radiosensitizing effect of RX-3117 was studied in A2780 ovarian cancer cells and non-small cell lung cancer cell lines and related to cell survival and the effect on cell cycle and cell cycle proteins. RX-3117 has a schedule-dependent radiosensitizing effect, but only at pre-incubation (dose modifying factors: 1.4-1.8), observed at pulse and fractionated irradiation...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27904601/evaluation-effects-of-nebulized-gentamicin-in-exacerbation-of-chronic-obstructive-lung-disease
#3
Forogh Soltaninejad, Soleiman Kheiri, Roya Habibian, Arshia Amra, Shahin Asgari-Savadjani
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. Exacerbation of COPD has negative effect on quality of life. Therapeutic effect of nebulized antibiotics in pulmonary infections has been reported previously. Hence, we evaluated the effect of nebulized gentamicin in acute exacerbation of COPD (AECOPD). MATERIALS AND METHODS: In this clinical trial study, 86 hospitalized patients with AECOPD were divided into two groups for using nebulized gentamicin twice daily (case group) and placebo (control group) for 5 days in addition to standard treatment...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903260/clinical-physiologic-and-radiographic-factors-contributing-to-development-of-hypoxemia-in-moderate-to-severe-copd-a-cohort-study
#4
J Michael Wells, Raul San Jose Estepar, Merry-Lynn N McDonald, Surya P Bhatt, Alejandro A Diaz, William C Bailey, Francine L Jacobson, Mark T Dransfield, George R Washko, Barry J Make, Richard Casaburi, Edwin J R van Beek, Eric A Hoffman, Frank C Sciurba, James D Crapo, Edwin K Silverman, Craig P Hersh
BACKGROUND: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic at baseline. We hypothesized that a combination of clinical, physiologic, and radiographic characteristics would predict development of resting hypoxemia after 5-years of follow-up in participants with moderate to severe COPD METHODS: We analyzed 678 participants with moderate-to-severe COPD recruited into the COPDGene cohort who completed baseline and 5-year follow-up visits and who were normoxic by pulse oximetry at baseline...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27891222/epidemiology-of-klebsiella-pneumoniae-bloodstream-infections-in-a-teaching-hospital-factors-related-to-the-carbapenem-resistance-and-patient-mortality
#5
Lijun Tian, Ruoming Tan, Yang Chen, Jingyong Sun, Jialin Liu, Hongping Qu, Xiaoli Wang
BACKGROUND: Although Klebsiella pneumoniae bloodstream infections (KP-BSIs) have recently attracted attention due to an alarming raise in morbidity and mortality, there have been few reports on the epidemiology of KP-BSIs in mainland China. We sought to describe the epidemiological, microbiological, and clinical characteristics of KP-BSIs, focusing on the risk factors of carbapenem resistance and patient mortality. METHODS: A retrospective analysis of WHONET data of KP-BSI patients admitted to a teaching hospital in Shanghai, China, between January 1, 2011 and December 31, 2015 was performed, and the annual percentage of patients with carbapenem-resistant K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27875408/diagnosing-acute-respiratory-distress-syndrome-in-resource-limited-settings-the-kigali-modification-of-the-berlin-definition
#6
Elisabeth D Riviello, Egide Buregeya, Theogene Twagirumugabe
PURPOSE OF REVIEW: The acute respiratory distress syndrome (ARDS) was re-defined by a panel of experts in Berlin in 2012. Although the Berlin criteria improved upon the validity and reliability of the definition, it did not make diagnosis of ARDS in resource limited settings possible. Mechanical ventilation, arterial blood gas measurements, and chest radiographs are not feasible in many regions of the world. In 2014, we proposed and applied the Kigali modification of the Berlin definition in a hospital in Rwanda...
November 19, 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27870589/results-of-a-prospective-study-evaluating-a-non-invasive-method-of-hemoglobin-adjustment-for-determining-the-diffusing-capacity-of-the-lung
#7
Karla E Foster, Rashmi D Sahay, Nanhua Zhang, William D Hardie
RATIONALE: Measurement of the lung diffusing capacity for carbon monoxide (DLCO) is significantly influenced by the pulmonary capillary blood volume. Consequently, measurements require adjustment for blood hemoglobin concentration (DLCOADJ) to allow meaningful clinical interpretation. Noninvasive point-of-care devices that measure hemoglobin transcutaneously provide immediate values for hemoglobin that may be useful in pulmonary function laboratories for determining DLCOADJ. OBJECTIVES: To test the hypothesis that DLCOADJ determinations obtained using a commerciallyavailable device for noninvasive, point-of-care measurement of blood hemoglobin concentrations are not importantly different from determinations obtained using hemoglobin concentrations measured conventionally on venous blood samples...
November 21, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27867531/steroid-pulse-therapy-was-effective-for-cardiac-sarcoidosis-with-ventricular-tachycardia-and-systolic-dysfunction
#8
Toshitaka Okabe, Tadayuki Yakushiji, Michiaki Hiroe, Yuji Oyama, Wataru Igawa, Morio Ono, Takehiko Kido, Seitaro Ebara, Kennosuke Yamashita, Myong Hwa Yamamoto, Shigeo Saito, Koichi Hoshimoto, Amemiya Kisaki, Naoei Isomura, Hiroshi Araki, Masahiko Ochiai
A 32-year-old man presented with palpitation. He was diagnosed with pulmonary sarcoidosis by lung biopsy. The electrocardiogram showed first-degree atrioventricular block and complete right bundle branch block (CRBBB). We planned to examine laboratory data, echocardiography, Holter monitoring, and gallium-67 scintigraphy. Before he went through all these exams, he developed ventricular tachycardia. After defibrillation was performed, his electrocardiogram revealed complete atrioventricular block. We observed elevation of serum angiotensin-converting enzyme levels...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27858374/prediction-of-fluid-responsiveness-an-update
#9
REVIEW
Xavier Monnet, Paul E Marik, Jean-Louis Teboul
In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion does not always increase cardiac output as one expects. Thus, after the very initial phase and/or if fluid losses are not obvious, predicting fluid responsiveness should be the first step of fluid strategy. For this purpose, the central venous pressure as well as other "static" markers of preload has been used for decades, but they are not reliable...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27856711/pulmonary-vascular-collagen-content-not-cross-linking-contributes-to-right-ventricular-pulsatile-afterload-and-overload-in-early-pulmonary-hypertension
#10
Zhijie Wang, David A Schreier, Hinnah Abid, Timothy A Hacker, Naomi C Chesler
Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery (PA) remodeling and right ventricular (RV) overload. We have previously uncovered collagen-mediated mechanisms of proximal PA stiffening in early HPH by manipulating collagen degradation and crosslinking using a transgenic mouse strain and a potent collagen cross-link inhibitor β-aminopropionitrile (BAPN). However, the roles of collagen in distal PA remodeling, overall RV afterload and RV hypertrophy in HPH remain unknown. Here, we used the same experimental strategy to investigate the impact of pulmonary vascular collagen content and cross-linking on steady and pulsatile RV afterload as well as RV hypertrophy in early HPH...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27847557/thoracic-ultrasound-a-complementary-diagnostic-tool-in-cardiology
#11
REVIEW
Guglielmo M Trovato
Clinical assessment and workup of patients referred to cardiologists may need an extension to chest disease. This requires more in-depth examination of respiratory co-morbidities due to uncertainty or severity of the clinical presentation. The filter and integration of ecg and echocardiographic information, addressing to the clues of right ventricular impairment, pulmonary embolism and pulmonary hypertension, and other less frequent conditions, such as congenital, inherited and systemic disease, usually allow more timely diagnosis and therapeutic choice...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27843548/assessment-of-proximal-pulmonary-arterial-stiffness-using-magnetic-resonance-imaging-effects-of-technique-age-and-exercise
#12
Jonathan R Weir-McCall, Anu Kamalasanan, Deidre B Cassidy, Allan D Struthers, Brian J Lipworth, J Graeme Houston
INTRODUCTION: To compare the reproducibility of pulmonary pulse wave velocity (PWV) techniques, and the effects of age and exercise on these. METHODS: 10 young healthy volunteers (YHV) and 20 older healthy volunteers (OHV) with no cardiac or lung condition were recruited. High temporal resolution phase contrast sequences were performed through the main pulmonary arteries (MPAs), right pulmonary arteries (RPAs) and left pulmonary arteries (LPAs), while high spatial resolution sequences were obtained through the MPA...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27837303/prediction-of-fluid-responsiveness-using-pulse-pressure-variation-in-infants-undergoing-ventricular-septal-defect-repair-with-median-sternotomy-or-minimally-invasive-right-thoracotomy
#13
Ding Han, Ya-Guang Liu, Yi Luo, Jia Li, Chuan Ou-Yang
Fluid management is challenging in infants after cardiopulmonary bypass. Pulse pressure variation (PPV) derived from pressure recording analytical method (PRAM) is based on lung-heart interaction during mechanical ventilation. A prospective observational study conducted in operating room tested PPV to predict fluid responsiveness in ventricular septal defect infants. Infants in open chest conditions with median sternotomy (n = 26) or minimally invasive right thoracotomy (n = 29) undergoing ventricular septal defect repair were enrolled...
November 11, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27819747/infant-position-in-neonates-receiving-mechanical-ventilation
#14
REVIEW
May Rivas-Fernandez, Marta Roqué I Figuls, Ana Diez-Izquierdo, Joaquin Escribano, Albert Balaguer
BACKGROUND: In patients of various ages undergoing mechanical ventilation (MV), it has been observed that positions other than the standard supine position, such as the prone position, may improve respiratory parameters. The benefits of these positions have not been clearly defined for critically ill newborns receiving MV.This is an update of a review first published in 2005 and last updated in 2013. OBJECTIVES: Primary objectiveTo assess the effects of different positioning of newborn infants receiving MV (supine vs prone, lateral decubitus or quarter turn from prone) in improving short-term respiratory outcomes...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27810156/pulmonary-arterial-capacitance-index-is-a-strong-predictor-for-adverse-outcome-in-children-with-idiopathic-and-heritable-pulmonary-arterial-hypertension
#15
Shinichi Takatsuki, Tomotaka Nakayama, Satoshi Ikehara, Hiroyuki Matsuura, David Dunbar Ivy, Tsutomu Saji
OBJECTIVES: To evaluate the clinical utility of pulmonary artery capacitance index (PACi) in the assessment of disease severity and prognostic value in children with idiopathic and heritable pulmonary arterial hypertension (PAH). STUDY DESIGN: PACi is defined as the ratio of stroke volume index over pulmonary pulse pressure. A retrospective study was performed to compare PACi, brain natriuretic peptide (BNP), 6-minute walk distance, New York Heart association (NYHA) functional class, and adverse outcomes (hospitalization due to heart failure, lung transplantation, and cardiac mortality) in 72 Japanese children (10 ± 3...
October 31, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27807253/lung-ultrasonography-to-diagnose-meconium-aspiration-syndrome-of-the-newborn
#16
Jing Liu, Hai-Ying Cao, Wei Fu
OBJECTIVE: To investigate the diagnostic value of lung ultrasonography for neonatal meconium aspiration syndrome (MAS). METHODS: This prospective observational study enrolled patients diagnosed with MAS based on medical history, clinical manifestations and chest X-ray and control newborns without MAS. During ultrasonography, each lung was divided into three regions (front, lateral, and back), using anterior and posterior axillary lines as the boundary. While scanning each region of the lungs, the hand piece was perpendicular or parallel to the ribs...
November 1, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27797350/ecg-case-of-the-month-heart-failure-in-a-man-from-chile
#17
D Luke Glancy, Glenn A Cochran, Frederick R Helmcke
A 49-year-old man visiting New Orleans from Chile comes to the hospital complaining of exertional dyspnea for 2 months with the more recent onset of ankle edema. He is a slender man with a blood pressure of 91/60 mmHg, crackles at both lung bases, and markedly distended neck veins. His cardiac rhythm is irregular. A soft murmur of mitral regurgitation and a soft S-3 are heard at the left ventricular apex. All four pedal pulses are easily palpable. Epigastric tenderness is noted on palpation; although the patient has a history of peptic ulcer disease, the tenderness is probably due to an enlarged left lobe of his liver, the result of hepatic congestion from his heart failure...
September 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27791285/signal-to-noise-ratio-t2-and-t2-for-hyperpolarized-helium-3-mri-of-the-human-lung-at-three-magnetic-field-strengths
#18
Peter Komlosi, Talissa A Altes, Kun Qing, Karen E Mooney, G Wilson Miller, Jaime F Mata, Eduard E de Lange, William A Tobias, Gordon D Cates, John P Mugler
PURPOSE: To evaluate T2 , T2*, and signal-to-noise ratio (SNR) for hyperpolarized helium-3 ((3) He) MRI of the human lung at three magnetic field strengths ranging from 0.43T to 1.5T. METHODS: Sixteen healthy volunteers were imaged using a commercial whole body scanner at 0.43T, 0.79T, and 1.5T. Whole-lung T2 values were calculated from a Carr-Purcell-Meiboom-Gill spin-echo-train acquisition. T2* maps and SNR were determined from dual-echo and single-echo gradient-echo images, respectively...
October 28, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27790119/paraneoplastic-dermatomyositis-in-hepatocellular-carcinoma-with-colonic-perforation-a-case-report
#19
Naoteru Miyata, Katsura Emoto, Yoshiaki Dei, Kazuhiro Tomiyasu, Ryoko Ishiyama, Tomofumi Horie, Gen Sakai, Toshiyuki Tahara
BACKGROUND: Dermatomyositis (DM) is an autoimmune disease characterized by cutaneous Gottron papules, heliotrope rash, and proximal myopathy. It may also present as a paraneoplastic syndrome that can complicate a variety of different cancers, such as lung, cervical, and breast cancer. However, the association with hepatocellular carcinoma (HCC) is extremely rare. Moreover, to our knowledge, there are no previous reports of colonic perforation following steroid pulse treatment for a DM patient...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27783918/a-randomized-trial-of-long-term-oxygen-for-copd-with-moderate-desaturation
#20
(no author information available yet)
Background Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. Methods We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%)...
October 27, 2016: New England Journal of Medicine
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