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https://www.readbyqxmd.com/read/28724445/sustained-benefit-from-combined-plasmapheresis-and-allogeneic-mesenchymal-stem-cells-transplantation-therapy-in-systemic-sclerosis
#1
Huayong Zhang, Jun Liang, Xiaojun Tang, Dandan Wang, Xuebing Feng, Fan Wang, Bingzhu Hua, Hong Wang, Lingyun Sun
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease involving the skin and several internal organs. Most therapies available for this disease are symptomatic. Given the difficulty in treating SSc, we conducted this study to investigate the effect of combined plasmapheresis (PE) and allogeneic mesenchymal stem cells transplantation (MSCT) therapy on SSc. METHODS: Fourteen patients underwent three repeated PE treatments with subsequent pulse cyclophosphamide on days 1, 3 and 5...
July 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28724041/effect-of-rhubarb-on-extravascular-lung-water-in-patients-with-acute-respiratory-distress-syndrome
#2
Jianxin He, Xiaoshui Si, Mingxia Ji, Jing Huang, Wenjuan Zheng, Jiao Wang, Junfeng Wang, Lijun Zhu
Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28722695/cardiac-cycle-efficiency-and-dicrotic-pressure-variations-new-parameters-for-fluid-therapy-a-pilot-observational-study
#3
Antonio Messina, Salvatore M Romano, Eleonora Bonicolini, Davide Colombo, Gianmaria Cammarota, Marco Chiostri, Francesco Della Corte, Paolo Navalesi, Didier Payen, Stefano Romagnoli
BACKGROUND: During a fluid challenge, the changes in cardiac performance and peripheral circulatory tone are closely related to the position of the ventricle on the Frank-Starling curve. Some patients have a good haemodynamic response to a fluid challenge, others hardly any response. The early haemodynamic effects of a fluid challenge could predict the final response before the entire fluid volume has been administered. OBJECTIVE: To assess whether a multivariate logistic regression model, including pulse pressure variation (PPV), cardiac cycle efficiency (CCE), arterial elastance and the difference between the dicrotic pressure and both systolic and mean arterial pressure (SAP - Pdic and MAP - Pdic) can predict cardiac responsiveness early during a fluid challenge in comparison with the standard procedure described elsewhere...
June 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28705304/clinical-practice-of-acute-respiratory-distress-syndrome-in-japan-a-nationwide-survey-and-scientific-evidences
#4
Sadatomo Tasaka, Koichiro Tatsumi
BACKGROUND: There has been limited information about epidemiology and clinical practice of acute respiratory distress syndrome (ARDS) in Japan. METHODS: An invitation letter to the web-based survey was mailed to all 871 board certified hospitals of the Japanese Respiratory Society. The questionnaires were designed to collect data on epidemiology and clinical practice of ARDS, including diagnostic measures and therapeutics. RESULTS: Within 4 months of the survey period, valid responses were obtained from 296 (34%) hospitals...
July 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28699887/upward-trend-of-dapsone-induced-methemoglobinemia-in-renal-transplant-community%C3%A2
#5
Sohail Abdul Salim, Lakshmi Ramachandran Nair, Venkataraman Palabindala, Iasmina Craici
Dapsone, a sulfone antibiotic, is used for prophylaxis of Pneumocystis jirovecii pneumonia in patients with documented sulfa allergy. Acquired methemoglobinemia caused by dapsone is not uncommon in patients with normal glucose-6-phosphate dehydrogenase (G6PD) levels. Discrepancy between oxygen saturation measured by pulse oximetry and arterial oxygen saturation (SpO2) readings, a phenomenon known as "saturation gap," is noted with cases of methemoglobinemia. Although its prevalence in renal transplant patients is poorly described, there is evidence that its incidence is increasing...
July 12, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28690287/stroke-volume-variation-svv-and-pulse-pressure-variation-ppv-as-indicators-of-fluid-responsiveness-in-sevoflurane-anesthetized-mechanically-ventilated-euvolemic-dogs
#6
Yusuke Endo, Jun Tamura, Tomohito Ishizuka, Takaharu Itami, Kiwamu Hanazono, Kenjiro Miyoshi, Tadashi Sano, Kazuto Yamashita, William W Muir
Changes in stroke volume variation (SVV) and pulse pressure variation (PPV) in response to fluid infusion were experimentally evaluated during vecuronium infusion and sevoflurane anesthesia in 5 adult, mechanically ventilated, euvolemic, beagle dogs. Sequential increases in central venous pressure (CVP; 3-7[baseline], 8-12, 13-17, 18-22 and 23-27 mmHg) were produced by infusing lactated Ringer's solution and 6% hydroxyethyl starch solution. Heart rate (beats/min), right atrial pressure (RAP, mmHg), pulmonary arterial pressure (PAP, mmHg), pulmonary capillary wedge pressure (PCWP, mmHg), transpulmonary thermodilution cardiac output (TPTDCO, L/min), stroke volume (SV, ml/beat), arterial blood pressure (ABP, mmHg), extravascular lung water (EVLW, ml), pulmonary vascular permeability index (PVPI, calculated), SVV (%), PPV (%) and systemic vascular resistance (SVR, dynes/sec/cm(5)) were determined at each predetermined CVP range...
July 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28684597/dynamic-hyperinflation-and-exercise-limitations-in-obese-asthmatic-women
#7
Palmira Gabriele Ferreira, Patricia Duarte Freitas, Aline Grandi Silva, Desiderio Cano Porras, Rafael Stelmach, Alberto Cukier, Frederico Leon Arrabal Fernandes, Mílton A Martins, Celso R F Carvalho
Obese individuals and patients with asthma can develop dynamic hyperinflation (DH) during exercise; however, no previous study has investigated DH as a factor associated with reduced exercise capacity in obese asthmatic women. The aim of the present study was to examine the occurrence of DH and exercise limitations in obese asthmatics. Obese grade II (obese group (Ob-G); BMI 35-39.9 kg/m2; n=36) and non-obese (non-obese group (NOb-G); BMI 18.5-29.9 kg/m2; n=18) asthmatic patients performed a cardiopulmonary test to quantify peak VO2 and a submaximal exercise test to assess DH...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28681537/a-potential-contribution-of-psoriasin-to-vascular-and-epithelial-abnormalities-and-inflammation-in-systemic-sclerosis
#8
T Takahashi, Y Asano, T Yamashita, K Nakamura, R Saigusa, S Miura, Y Ichimura, T Toyama, M Hirabayashi, T Taniguchi, A Yoshizaki, S Sato
BACKGROUND: Antimicrobial peptides have attracted much attention as a member of disease-associated molecules in systemic sclerosis (SSc), which is pathologically characterized by immune abnormalities, vasculopathy, and tissue fibrosis. OBJECTIVE: To investigate the potential contribution of one of the anitimicrobial peptides psoriasin to the development of SSc. METHODS: Psoriasin expression in the skin samples and sera derived from SSc patients and its correlation with clinical parameters were analyzed...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28661960/longitudinal-study-of-the-influence-of-lung-function-on-vascular-health-from-adolescence-to-early-adulthood-in-a-british-multiethnic-cohort
#9
Yao Lu, Lum Sooky, Maria João Silva, Oarabile R Molaodi, Alexis Karamanos, J Kennedy Cruickshank, Seeromanie Harding
BACKGROUND: Vascular and lung function develop and decline over the life course; both predict cardiovascular events and mortality but little is known of how they develop over time. We analysed their relationship in a multiethnic cohort study to test whether lung function from early adolescence to young adulthood affected vascular indices. METHODS: 'DASH' (http://dash.sphsu.mrc.ac.uk) included 6643 children aged 11-13 years in 2003; a representative 10% sample (n = 665) participated in a pilot follow-up in 2013...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28637572/investigating-cyclooxygenase-inhibition-in-a-rat-pulmonary-contusion-model-a-laboratory-study-finding-no-improvement-with-ibuprofen
#10
John P Sharpe, Nick R Khan, Arindam R Chatterjee, Jinsong Huang, Louis J Magnotti, Martin A Croce, Timothy C Fabian
Minimal advances have been made in the management of pulmonary contusions (PCs). The purpose of this study was to evaluate the impact of cyclooxygenase inhibition on outcomes following PC in a rat model. PC was induced in anesthetized adult rats. Ibuprofen was given to the treatment group (TG) and water was given to the control group (CG). Lung injury was assessed with pulse oximetry, arterial blood gases, CT, and histopathologic examination. Inflammation was measured with both serum and bronchoalveolar lavage (BAL) levels of tumor necrosis factor α and interleukin-6...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28629640/is-physical-activity-a-modifier-of-the-association-between-air-pollution-and-arterial-stiffness-in-older-adults-the-sapaldia-cohort-study
#11
Simon Endes, Emmanuel Schaffner, Seraina Caviezel, Julia Dratva, Daiana Stolz, Christian Schindler, Nino Künzli, Arno Schmidt-Trucksäss, Nicole Probst-Hensch
INTRODUCTION AND OBJECTIVES: Air pollution and insufficient physical activity have been associated with inflammation and oxidative stress, molecular mechanisms linked to arterial stiffness and cardiovascular disease. There are no studies on how physical activity modifies the association between air pollution and arterial stiffness. We examined whether the adverse cardiovascular effects of air pollution were modified by individual physical activity levels in 2823 adults aged 50-81 years from the well-characterized Swiss Cohort Study on Air Pollution and Lung and Heart Diseases (SAPALDIA)...
June 13, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28625256/-comparison-of-effect-of-norepinephrine-and-terlipressin-on-patients-with-ards-combined-with-septic-shock-a-prospective-single-blind-randomized-controlled-trial
#12
Zhi Chen, Ping Zhou, Yuanhua Lu, Chunli Yang
OBJECTIVE: To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock. METHODS: A prospective single-blind randomized controlled trial was conducted. ARDS patients with septic shock admitted to the Department of Critical Care Medicine of Jiangxi Provincial People's Hospital from January 1st, 2015 to May 1st, 2016 were enrolled...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625234/-effect-of-global-end-diastolic-volume-index-guidance-fluid-resuscitation-in-elderly-patients-with-septic-shock
#13
Shuang Ma, Rumin Zhang, Shifu Wang, Meiling Zhao, Lei Wang, Yun Zhang
OBJECTIVE: To evaluate the effect of global end diastolic volume index (GEDVI) on fluid resuscitation in elderly patients with septic shock. METHODS: A prospective randomized controlled trial (RCT) was conducted. Septic shock patients over 65 years admitted to intensive care unit (ICU) of Shandong Province, Zibo Central Hospital from January 2013 to December 2015 were enrolled. The patients were randomly divided into control group and observation group, 20 cases in each group...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625165/transpulmonary-thermodilution-advantages-and-limits
#14
REVIEW
Xavier Monnet, Jean-Louis Teboul
BACKGROUND: For complex patients in the intensive care unit or in the operating room, many questions regarding their haemodynamic management cannot be answered with simple clinical examination. In particular, arterial pressure allows only a rough estimation of cardiac output. Transpulmonary thermodilution is a technique that provides a full haemodynamic assessment through cardiac output and other indices. MAIN BODY: Through the analysis of the thermodilution curve recorded at the tip of an arterial catheter after the injection of a cold bolus in the venous circulation, transpulmonary thermodilution intermittently measures cardiac output...
June 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28624061/new-noncontact-sensor-for-detecting-pulmonary-tumors-during-video-assisted-thoracic-surgery
#15
Koichi Akayama, Yoshihiro Miyata, Tomohiro Kawahara, Morihito Okada, Makoto Kaneko, Masazumi Okajima, Hideki Ohdan
BACKGROUND: Small pulmonary tumors are difficult to localize during video-assisted thoracic surgery (VATS) because of lack of direct tissue contact. However, in partial lung resection, tumor localization is quite important. The aim of this study was to evaluate the safety and feasibility of a new noncontact sensor for detecting pulmonary nodules during VATS using human and porcine models. METHODS: The sensor, based on the principle of phase differences, comprises an air nozzle for producing air pulse jets and an optical fiber sensor to measure phase differences and visualize object stiffness...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28619111/two-minute-disconnection-technique-with-a-double-lumen-tube-to-speed-the-collapse-of-the-non-ventilated-lung-for-one-lung-ventilation-in-thoracoscopic-surgery
#16
Qiongzhen Li, Xiaofeng Zhang, Jingxiang Wu, Meiying Xu
BACKGROUND: Thoracic surgery requires the effective collapse of the non-ventilated lung. In the majority of cases, we accomplished, accelerated lung collapse using a double-lumen tube (DLT). We hypothesized that using the two-minute disconnection technique with a DLT would improve lung collapse during subsequent one-lung ventilation. METHODS: Fifty patients undergoing thoracoscopic surgery with physical classification I or II according to the American Society of Anesthesiologists were randomly divided into two groups for respiratory management of one-lung ventilation (OLV)...
June 15, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28614220/rituximab-was-used-to-treat-recurrent-igg4-related-hypophysitis-with-ophthalmopathy-as-the-initial-presentation-a-case-report-and-literature-review
#17
REVIEW
Wei-Jun Gu, Qian Zhang, Jian Zhu, Jie Li, Shi-Hui Wei, Yi-Ming Mu
RATIONALE: Immunoglobulin G4 (IgG4)-related hypophysitis is a type of IgG4-related disease (IgG4-RD), which is characterized by plasma cells infiltration in the pituitary causing functional changes and (or) space-occupying effect in the pituitary. IgG4-related hypophysitis is sensitive to hormone therapy in most patients, but recurrence is very likely. PATIENT CONCERNS: Here, we report a 57-year-old male patient with bilateral eye redness as the initial presentation...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28604331/evidence-of-persistence-of-prevotella-spp-in-the-cystic-fibrosis-lung
#18
D F Gilpin, K A Nixon, M Bull, S J McGrath, L Sherrard, J M Rolain, E Mahenthiralingam, J S Elborn, M M Tunney
PURPOSE: Prevotella spp. represent a diverse genus of bacteria, frequently identified by both culture and molecular methods in the lungs of patients with chronic respiratory infection. However, their role in the pathogenesis of chronic lung infection is unclear; therefore, a more complete understanding of their molecular epidemiology is required. METHODOLOGY: Pulsed Field Gel Electrophoresis (PFGE) and Random Amplified Polymorphic DNA (RAPD) assays were developed and used to determine the degree of similarity between sequential isolates (n=42) from cystic fibrosis (CF) patients during periods of clinical stability and exacerbation...
June 13, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28597758/longitudinal-change-in-pulmonary-arterial-capacitance-as-an-indicator-of-prognosis-and-response-to-therapy-and-in-pulmonary-arterial-hypertension
#19
Sarah K Medrek, Chad Kloefkorn, Duc T M Nguyen, Edward A Graviss, Adaani E Frost, Zeenat Safdar
Pulmonary arterial hypertension (PAH) is a chronic progressive disease that leads to right heart failure and death. Pulmonary arterial capacitance (PAC), defined as stroke volume divided by the pulmonary pulse pressure, has been identified as a prognostic factor in PAH. The impact of changes in PAC over time, however, is unclear. We evaluated changes in PAC over time to determine if such changes predicted transplant-free survival. A single-center retrospective study of consecutive group 1 PAH patients who had two or more right heart catheterizations (RHC) between January 2007 and June 2016 was undertaken...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28589262/the-surgical-outcomes-of-lung-cancer-combined-with-interstitial-pneumonia-a-single-institution-report
#20
Daisuke Taniguchi, Naoya Yamasaki, Takuro Miyazaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Go Hatachi, Tomoyuki Kakugawa, Noriho Sakamoto, Hiroshi Mukae, Takeshi Nagayasu
PURPOSE: Several studies have reported that an acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection in patients with non-small cell lung cancer (NSCLC); however, the perioperative management strategy is controversial. METHODS: The data of lung cancer patients at Nagasaki University Hospital from June 1994 to October 2013 were retrospectively reviewed. RESULTS: Among all 1701 NSCLC patients who underwent lung resection, 59 (3...
June 6, 2017: Surgery Today
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