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Jeffrey M Harris, Christopher R Cabanski, Heleen Scheerens, Divya Samineni, Mary S Bradley, Colette Cochran, Petra Staubach, Martin Metz, Gordon Sussman, Marcus Maurer
No abstract text is available yet for this article.
December 2016: Journal of Allergy and Clinical Immunology
Jeffrey M Harris, Romeo Maciuca, Mary S Bradley, Christopher R Cabanski, Heleen Scheerens, Jeremy Lim, Fang Cai, Mona Kishnani, X Charlene Liao, Divya Samineni, Rui Zhu, Colette Cochran, Weily Soong, Joseph D Diaz, Patrick Perin, Miguel Tsukayama, Dimo Dimov, Ioana Agache, Steven G Kelsen
BACKGROUND: Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. In patients with mild asthma, quilizumab reduced serum IgE and attenuated the early and late asthmatic reaction following whole lung allergen challenge. This study evaluated the efficacy and safety of quilizumab in adults with allergic asthma, inadequately controlled despite high-dose inhaled corticosteroids (ICS) and a second controller...
March 18, 2016: Respiratory Research
Gail M Gauvreau, Jeffrey M Harris, Louis-Philippe Boulet, Heleen Scheerens, J Mark Fitzgerald, Wendy S Putnam, Donald W Cockcroft, Beth E Davis, Richard Leigh, Yanan Zheng, Barbro Dahlén, Yehong Wang, Romeo Maciuca, Irvin Mayers, X Charlene Liao, Lawren C Wu, John G Matthews, Paul M O'Byrne
Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE-positive cells with antibodies against M1 prime can inhibit the production of new IgE and significantly reduce the levels of serum IgE. We report results from two trials that investigated the safety, pharmacokinetics, and activity of quilizumab, a humanized monoclonal antibody targeting specifically the M1 prime epitope of membrane IgE, in subjects with allergic rhinitis (NCT01160861) or mild allergic asthma (NCT01196039)...
July 2, 2014: Science Translational Medicine
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