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https://www.readbyqxmd.com/read/28231576/molecular-markers-involved-in-tumorigenesis-of-thyroid-carcinoma-focus-on-aggressive-histotypes
#1
Gustavo C Penna, Fernanda Vaisman, Mario Vaisman, Manuel Sobrinho-Simões, Paula Soares
Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma. Papillary thyroid carcinoma is the most common endocrine cancer, and its incidence is steadily increasing. Lethality and aggressiveness of TCDFC is inversely correlated with differentiation degree. In this review, an emphasis has been put on molecular markers involved in tumorigenesis of thyroid carcinoma with a focus on aggressive histotypes and the role of such biomarkers in predicting thyroid cancer outcome...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28230245/ct-guided-percutaneous-hookwire-localization-increases-the-efficacy-and-safety-of-vats-for-pulmonary-nodules
#2
Theo J Klinkenberg, Lars Dinjens, Rienhart F E Wolf, Anthonie J van der Wekken, Caroline van de Wauwer, Geertruida H de Bock, Wim Timens, Massimo A Mariani, Harry J M Groen
BACKGROUND AND OBJECTIVES: The diagnosis of pulmonary nodules of unknown origin is challenging, and such nodules are not always suitable for transthoracic needle biopsy. With the advent of video assisted thoracic surgery (VATS) and CT-guided percutaneous hookwire localization (CT-PHL) we hypothesized that the combination of these two procedures will improve early diagnosis. METHODS: Selection criteria were a nodule not well approachable with fine needle biopsy and the therapeutic consequences of a diagnosis as assessed by the multidisciplinary oncology board...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28226508/temperature-monitoring-during-radiofrequency-ablation-of-liver-in-vivo-trials
#3
P Saccomandi, G Frauenfelder, C Massaroni, M A Caponera, A Polimadei, F Taffoni, F M Di Matteo, G Costamagna, F Giurazza, E Schena, P Saccomandi, G Frauenfelder, C Massaroni, M A Caponera, A Polimadei, F Taffoni, F M Di Matteo, G Costamagna, F Giurazza, E Schena, F Taffoni, F M Di Matteo, F Giurazza, E Schena, G Costamagna, A Polimadei, G Frauenfelder, P Saccomandi, C Massaroni
Radiofrequency ablation (RFA) is a minimally invasive procedure used to treat tumors by means of hyperthermia, mostly through percutaneous approach. The tissue temperature plays a pivotal role in the achievement of the target volume heating, while sparing the surrounding healthy tissue from thermal damage. Several techniques for thermometry during RFA are investigated, most of them based on the use of single-point measurement system (e.g., thermocouples). The measurement of temperature map is crucial for the real-time control and fine adjustment of the treatment settings, to optimize the shape and size of the ablated volume...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225995/clinical-impact-of-thyroglobulin-tg-and-tg-autoantibody-tgab-measurements-in-needle-washouts-of-neck-lymph-node-biopsies-in-the-management-of-patients-with-papillary-thyroid-carcinoma
#4
M Cecilia Martins-Costa, Rui M B Maciel, Teresa S Kasamatsu, Claudia C D Nakabashi, Cleber P Camacho, Felipe Crispim, Elza S Ikejiri, M Conceição O Mamone, Danielle M Andreoni, Rosa Paula M Biscolla
Objectives: The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the follow-up of patients with papillary thyroid carcinoma (PTC). However, there are limited data regarding the measurement of anti-Tg antibodies in these washouts (TgAb-FNAB), and it is not clear whether these antibodies interfere with the assessment of Tg-FNAB or whether there are other factors that would more consistently justify the finding of low Tg-FNAB in metastatic LNs...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28224716/fine-needle-aspiration-cytology-of-the-papillary-thyroid-carcinoma-with-a-solid-component-a-cytological-and-clinical-correlation
#5
Ryuji Ohashi, Yukihiro Murase, Miyuki Matsubara, Yasuhiko Watarai, Takehito Igarashi, Iwao Sugitani, Zenya Naito
BACKGROUND: Solid variant of papillary thyroid carcinoma is a rare subtype of papillary thyroid carcinoma (PTC) containing a solid component (SC), and thus its cytological and clinicopathological features remain elusive. We examined fine needle aspiration (FNA) cytological features of PTC with variable degrees of SC (20-80% of the tumor)(PTCSC) in comparison to well-differentiated PTC (WPTC). METHODS: Twenty-six cases of PTCSC were histologically stratified into major-SC (SC >50% of the tumor) and minor-SC (<49%) groups...
February 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28223766/cutaneous-implantation-metastasis-of-papillary-thyroid-carcinoma-following-fine-needle-aspiration-biopsy
#6
Chan Ho Na, Dong Jin Kim, Min Sung Kim, Bong Seok Shin
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28220939/acute-diffuse-thyroid-swelling-a-rare-complication-of-fine-needle-aspiration
#7
Wai Kiu Tang, Kunwar S S Bhatia, Angel S W Pang, Anil Ahuja
We present a case illustrating the rare complication of acute generalized thyroid swelling shortly after sonographic-guided fine needle aspiration of a thyroid nodule. Ultrasound revealed the presence of characteristic linear hypoechoic avascular areas interspersed throughout the gland suggestive of edema. The patient was treated conservatively, with near complete normalization of the thyroid within 24 hours. Recognition of this potential complication is important, as the rapid onset of diffuse thyroid enlargement is often alarming but typically has a transient and self-limiting course...
February 21, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28220692/diagnostic-approach-using-ercp-guided-transpapillary-forceps-biopsy-or-eus-guided-fine-needle-aspiration-biopsy-according-to-the-nature-of-stricture-segment-for-patients-with-suspected-malignant-biliary-stricture
#8
Yun Nah Lee, Jong Ho Moon, Hyun Jong Choi, Hee Kyung Kim, Seo-Youn Choi, Moon Han Choi, Tae Hee Lee, Tae Hoon Lee, Sang-Woo Cha, Sang-Heum Park
In malignant biliary stricture (MBS), the diagnostic accuracy of ERCP-based tissue sampling is insufficient. EUS-guided fine needle aspiration biopsy (EUS-FNAB) is emerging as a reliable diagnostic procedure. This study aimed to evaluate the usefulness of a diagnostic approach using ERCP-guided transpapillary forceps biopsy (TPB) or EUS-FNAB according to the characteristics of suspected MBS. Consecutive patients diagnosed with suspected MBS with obstructive jaundice and/or cholangitis were enrolled prospectively...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28218999/assessment-of-morbidity-and-mortality-associated-with-eus-guided-fna-for-pancreatic-cystic-lesions-a-system-review-and-meta-analysis
#9
REVIEW
Huiyun Zhu, Fei Jiang, Jianwei Zhu, Yiqi Du, Zhendong Jin, Zhaoshen Li
BACKGROUND AND AIM: With increased availability of imaging technology, detection of pancreatic cystic lesions (PCLs) is on the rise. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) improves the diagnosis accuracy of PCLs. Systematic evaluation of morbidity and mortality associated with EUS-FNA for PCLs has not been performed. We conducted a systematic review and meta-analysis of morbidity and mortality associated with EUS-FNA. METHODS: A literature search for relevant English-language articles was conducted on PubMed and EMBASE databases...
February 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28218205/endoscopic-ultrasound-guided-fine-needle-aspiration-of-peritoneal-deposits-in-patients-with-ascites-of-unknown-cause-with-videos
#10
Piyush Somani, Malay Sharma, Amol Patil, Charu Shastri
No abstract text is available yet for this article.
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28218198/harmonic-contrast-enhanced-endoscopic-ultrasound-fine-needle-aspiration-fact-or-fiction
#11
REVIEW
Andrada Seicean, Mariana Jinga
The negative predictive value of endoscopic ultrasonography fine-needle aspiration is relatively low. To achieve the improvement of the diagnostic yield, the following were proposed: a higher number of passes, the presence of the rapid on-site cytopathologist evaluation, the fanning technique, or the repetition of the fine needle biopsy. Harmonic contrast-enhanced endosonography may better identify the targeted area in the lesions by avoiding the inside necrosis and the vessels of fibrosis, so it can guide the fine-needle aspiration...
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28218197/role-of-contrast-harmonic-endoscopic-ultrasound-in-pancreatic-cystic-lesions
#12
REVIEW
Marta Serrani, Andrea Lisotti, Giancarlo Caletti, Pietro Fusaroli
Incidental pancreatic cysts (PCs) are frequently encountered in the general population often in asymptomatic patients who undergo imaging tests to investigate unrelated conditions. The detection of a PC poses a significant clinical dilemma, as the differential diagnosis is quite broad ranging from benign to malignant conditions. Endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) has been reported to be an accurate tool in the differential diagnosis; however, its sensitivity is suboptimal and false negative results do occur...
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28218194/role-of-contrast-enhanced-endoscopic-ultrasound-in-lymph-nodes
#13
REVIEW
Michael Hocke, Andre Ignee, Christoph Dietrich
Diagnosing unclear lymph node (LN) enlargements in the mediastinum and abdomen is the most important indication of endoscopic ultrasound (EUS)-fine needle aspiration (FNA) after the diagnosis and treatment of pancreatic diseases. Investigating LNs in these areas can happen in different clinical settings. Mostly, it is the first modality in general LN diseases without any peripheral LN enlargements. On the other hand, it can be the question of LN involvement in a known or suspected primary tumor. Due to EUS-FNA cytology, those questions can be answered highly, accurately...
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28218193/can-contrast-harmonic-endoscopic-ultrasonography-replace-endoscopic-ultrasonography-guided-fine-needle-aspiration-in-patients-with-solid-pancreatic-lesions-an-american-perspective
#14
EDITORIAL
Joseph Yoo, Linda H Yan, Ali A Siddiqui
No abstract text is available yet for this article.
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28217985/two-unusual-variants-of-pancreatic-neuroendocrine-tumor-and-their-potential-pitfalls-on-fine-needle-aspiration-cytology
#15
Abby M Richmond, Sanjana Mehrotra
Endoscopic ultrasound-guided fine-needle aspiration is increasingly utilized for the diagnosis of pancreatic lesions. Although operator dependent, the procedure has good overall performance characteristics and is minimally invasive; however, accuracy and sensitivity are reportedly lower for pancreatic neuroendocrine tumor (PanNET) compared with the more common pancreatic ductal adenocarcinoma (pACA). The underperformance is further exacerbated by the unusual cases of PanNET presenting with variant cytomorphology...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217980/reproducibility-of-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-category-using-the-bethesda-system-for-reporting-thyroid-cytology-when-reviewing-slides-from-different-institutions-a-study-of-interobserver-variability-among
#16
Vijayalakshmi Padmanabhan, Carrie B Marshall, Guliz Akdas Barkan, Mohiedean Ghofrani, Alice Laser, Idris Tolgay Ocal, Charles David Sturgis, Rhona Souers, Daniel F I Kurtycz
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy, malignant, and unsatisfactory with an aim to standardize diagnostic criteria. Reported rate of AUS/FLUS category in the literature has varied from 3% to 20.5%. METHODS: The aim of this study was to assess interobserver variability among cytopathologists to assess reproducibility of the AUS/FLUS category...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217964/is-fine-needle-aspiration-really-not-necessary-in-patients-with-thyroid-nodules%C3%A2-%C3%A2-%C3%A2-1-cm-with-highly-suspicious-features-on-ultrasonography-and-candidates-for-active-surveillance
#17
Pedro Weslley Rosario, Alexandre Lemos Silva, Maria Regina Calsolari
BACKGROUND: The low rate of progression associated with the potential complications of thyroidectomy makes active surveillance an increasingly recommended management in low-risk papillary microcarcinomas of the thyroid (PMT). The objective of this study was to report the results of fine needle aspiration (FNA) of nodules ≤ 1 cm with highly suspicious appearance on ultrasonography (US) in patients who are potential candidates for active surveillance. METHODS: We revised thyroid nodules ≤ 1 cm with highly suspicious appearance on US in patients without known distant metastases, suspicion of extrathyroid extension, or suspicious lymph nodes on US...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217943/fine-needle-cytology-pre-surgical-differentiation-of-parathyroid-neoplasms-is-it-reliable
#18
A Caleo, M Vitale, L Valvano, M Siano, B Angrisani, M Forlenza, A Massari, A Puzziello, F Salzano, P Zeppa
BACKGROUND: Fine needle cytology (FNC) of a parathyroid neoplasia (PN) is reliable, but needs to be confirmed by Parathormone (PTH) and Thyroglobulin (TG) immunoassay on needle washing or by immunocytochemistry (ICC) evaluation. The differentiation between parathyroid adenoma (PA), atypical adenoma (PAA) and carcinoma (PC) is difficult on histology or even impossible on FNC. The aim of this study was to evaluate possible cytological criteria to classify FNC-PN further. METHODS: Twenty-three FNC samples of PN and parathyroid cysts were rather then have been reviewed...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28217870/adult-ocular-medulloepithelioma-diagnosed-by-transscleral-fine-needle-aspiration-a-case-report
#19
Amir Mahdjoubi, Nathalie Cassoux, Christine Levy-Gabriel, Laurence Desjardins, Jan Klos, Martial Caly, Tatjana Vlajnic, Sophie Gardrat, Jerzy Klijanienko
Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217853/use-of-cytological-samples-of-metastatic-melanoma-for-ancillary-studies
#20
H M Ko, M A Saieg, G da Cunha Santos, S Kamel-Reid, S L Boerner, W R Geddie
OBJECTIVE: Fine needle aspiration (FNA) is widely used in the diagnosis of metastatic melanoma, both at initial presentation and in the setting of recurrent disease. The purpose of this study was to evaluate the performance of confirmatory immunohistochemistry (IHC) and molecular analysis of the BRAF mutation in cytological preparations of metastatic melanoma. METHODS: A 2-year retrospective review of pathology reports was performed on cytological samples of metastatic melanoma at the University Health Network (Toronto, Canada) and the Santa Casa Medical School (Sao Paulo, Brazil)...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
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