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Carlo Vecchioli Scaldazza, Carolina Morosetti, Rosita Giampieretti, Rossana Lorenzetti, Marinella Baroni
INTRODUCTION: This study compared percutaneous tibial nerve stimulation (PTNS) versus electrical stimulation with pelvic floor muscle training (ES + PFMT) in women with overactive bladder syndrome (OAB). MATERIALS AND METHODS: 60 women with OAB were enrolled. Patients were randomized into two groups. In group A, women underwent ES with PFMT, in group B women underwent PTNS. RESULTS: A statistically significant reduction in the number of daily micturitions, episo¬des of nocturia and urge incontinence was found in the two groups but the difference was more substantial in women treated with PTNS; voided volume increased in both groups...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Lalit Kumar, Jorge Liwanag, Eleni Athanasakos, Amanda Raeburn, Natalia Zarate-Lopez, Anton V Emmanuel
AIM: Chronic constipation can be aetiopathogenically classified in to slow transit constipation (STC), rectal evacuation difficulty (RED) or a combination (BOTH). Although the efficacy of percutaneous tibial nerve stimulation (PTNS) in faecal incontinence has been well proven, a current literature search identifies only one study which assessed its effect on constipation. We aimed to evaluate the effectiveness of PTNS in patients with different causes of constipation. METHOD: 34 patients (30 women, median age 50 (20-79) years with constipation who had previously failed maximal laxative and biofeedback therapy participated in the study...
May 20, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
S L Kelly, S C Radley, S R Brown
AIM: Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive treatment for faecal incontinence. Many patients with faecal incontinence have coexisting pelvic floor disorders such as urinary incontinence and vaginal symptoms. We utilized a pelvic floor assessment tool to analyse any effect of PTNS on global pelvic floor function. METHODS: Patients with faecal incontinence attending our institution who had failed to respond sufficiently to biofeedback were offered a course of PTNS...
May 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
P Moya, P Parra, A Arroyo, E Peña, J Benavides, R Calpena
BACKGROUND: Sacral nerve stimulation and percutaneous posterior tibial nerve stimulation have been described previously as effective treatments for fecal incontinence. Nevertheless, there does not exist any study that compares the efficiency of both. The aim of this study was to compare the use of SNS and PPTNS in males with FI. METHODS: We conducted a prospective cohort study on men with FI treated with SNS or PTNS in the Coloproctology Unit of the University General Hospital of Elche and Reina Sofia of Murcia between January 2010 and December 2011...
May 2016: Techniques in Coloproctology
Melissa T Sanford, Anne M Suskind
While neuromodulation is a well-established treatment option for patients with non-neurogenic overactive bladder and urinary retention, its applicability to the neurogenic bladder population has only recently been examined more in depth. In this article we will discuss the outcomes, contraindications, and special considerations of sacral and percutaneous tibial nerve stimulation (PTNS) in patients with neurogenic lower urinary tract dysfunction.
February 2016: Translational Andrology and Urology
Stefania Musco, Maurizio Serati, Giuseppe Lombardi, Ermal Lumi, Annunziata Isabella Parisi, Giulio Del Popolo, Enrico Finazzi Agrò
INTRODUCTION: Percutaneous tibial nerve stimulation (PTNS) is an established treatment for overactive bladder (OAB), especially in women with other concomitant pelvic disorders, such as sexual impairment. AIM: To evaluate the impact of PTNS on female sexual dysfunction (FSD) in women undergoing PTNS for OAB and analyze the results. METHODS: An observational prospective study was conducted in two Italian centers. Consecutive women undergoing PTNS for dry OAB were enrolled from May 2013 to June 2014...
February 2016: Journal of Sexual Medicine
Valentín Manríquez, Rodrigo Guzmán, Michel Naser, Amalia Aguilera, Simonie Narvaez, Ariel Castro, Steven Swift, G Alessandro Digesu
INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate the effectiveness of transcutaneous posterior tibial nerve stimulation (T.C. PTNS) versus extended release oxybutynin (E.R.O.) in patients with overactive bladder. MATERIALS AND METHODS: Seventy female patients were randomized to receive either 10mg E.R.O. daily or T.C. PTNS, using a TENS machine program with the 20Hz, 200 cycles/s, and normal stimulation setting for two 30-min sessions, each week for a 12-week period...
January 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Sadık Kızılyel, Ahmet Karakeçi, Tunç Ozan, İhsan Ünüş, Osman Barut, Rahmi Onur
OBJECTIVE: To evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS), either alone or combined with an anticholinergic agent, in treating patients with an overactive bladder (OAB) in whom previous conservative treatment failed. MATERIAL AND METHODS: In this study, we included a total of 30 female patients with OAB in whom all conventional therapies failed between January 2010 and April 2011. Patients were randomly divided into three groups: Group 1, PTNS group; Group 2, patients receiving an anticholinergic agent; and Group 3, patients receiving both PTNS and anticholinergic agent...
December 2015: Turkish Journal of Urology
Elita Wibisono, Harrina E Rahardjo
AIM: to evaluate the effectiveness of short-term PTNS for non-neurogenic OAB in adults systematically by comparing with sham procedure and other treatments. METHODS: we performed a systematic review of cohort study. Data sources were MEDLINE, EMBASE, CINAHL, National Library for Health, Cochrane, and google scholar from 2005 through 2015. Meta-analysis was performed using the random effects model. Heterogeneity of effects was assessed by calculating I2 statistic...
July 2015: Acta Medica Indonesiana
Sahin Kabay, Sibel Canbaz Kabay, Mustafa Cetiner, Emine Mestan, Mehmet Sevim, Selahattin Ayas, Hilmi Ozden, Handan Ozisik Karaman
OBJECTIVE: To investigate the effect of percutaneous posterior tibial nerve stimulation (PTNS) treatment after 12 weeks on urodynamic and clinical findings in patients with Parkinson's disease (PD) with neurogenic detrusor overactivity. METHODS: A total of 47 patients with PD with neurogenic detrusor overactivity were enrolled in the study. Urodynamic studies before and after 12-week PTNS treatment were performed. International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), Overactive Bladder Questionnaire (OAB-V8), and Overactive Bladder Questionnaire Short Form (OAB-q SF) have been assessed before and after PTNS treatment...
January 2016: Urology
Kathleen Beusterien, Michael J Kennelly, John F P Bridges, Kaitlan Amos, Mary Jo Williams, Sandip Vasavada
AIMS: Refractory overactive bladder (OAB) treatments, including sacral neuromodulation (SNM), onabotulinumtoxin A (OnabotA), and percutaneous tibial nerve stimulation (PTNS), differ considerably. Best-Worst Scaling (BWS) was used to assess patient preferences for these treatments. METHODS: A cross-sectional Web survey, based on findings from qualitative interviews with 23 OAB patients and 7 clinical experts, was conducted with idiopathic OAB patients in the US and UK...
November 2016: Neurourology and Urodynamics
Sibel Canbaz Kabay, Sahin Kabay, Emine Mestan, Mustafa Cetiner, Selahattin Ayas, Mehmet Sevim, Hilmi Ozden, Handan Ozisik Karaman
AIMS: The aim of this study is to determine the sustained therapeutic efficacy and treatment intervals for PTNS in NOAB with MS, offering periodic additional treatments during 1 year in patients who completed an initial course of 12 consecutive weekly sessions. METHODS: A total of 34 patients enrolled to the PTNS treatment and 21 patients completed the 1 year PTNS treatment with a tapering protocol of 6, 9, and 12 months of therapy, respectively. After 12 weeks of therapy, PTNS was applied at 14 day intervals for 3 months, 21 day intervals for 3 months, and 28 day intervals for 3 months...
January 2017: Neurourology and Urodynamics
Hashim Hashim, Kathleen Beusterien, John F P Bridges, Kaitlan Amos, Linda Cardozo
OBJECTIVE: To evaluate patient preferences for refractory overactive bladder (OAB) treatments: sacral neuromodulation (SNM), onabotulinum toxin A (Botox(®)), and percutaneous tibial nerve stimulation (PTNS). MATERIALS AND METHODS: A cross-sectional Web survey was conducted with UK idiopathic OAB patients, recruited by a market research company. Preference was explored using direct questioning, comparing SNM, Botox, and PTNS, and via best-worst scaling (BWS). In BWS, patients prioritized subsets of 13 treatment characteristics (attributes) across 13 choice tasks, identifying the attribute they considered best and worst in each task...
October 2015: International Urology and Nephrology
Mohamed A Thaha, Amin A Abukar, Noel N Thin, Anthony Ramsanahie, Charles H Knowles
BACKGROUND: Faecal incontinence (FI) and constipation are both socially-embarrassing and physically-disabling conditions that impair quality of life. For both, surgery may be required in a minority of people when more conservative measures fail. However, the invasiveness and irreversible nature of direct surgery on bowel and sphincter muscles, poor long-term outcomes and well-established compIications makes such procedures unappealing for these benign conditions. A less-invasive surgical option to treat faecal incontinence and constipation is direct, low-voltage stimulation of the sacral nerve roots, termed sacral nerve stimulation (SNS)...
2015: Cochrane Database of Systematic Reviews
Charles H Knowles, Emma J Horrocks, Stephen A Bremner, Natasha Stevens, Christine Norton, P Ronan O'Connell, Sandra Eldridge
BACKGROUND: Percutaneous tibial nerve stimulation (PTNS) is a new ambulatory therapy for faecal incontinence. Data from case series suggest it has beneficial outcomes in 50-80% patients; however its effectiveness against sham electrical stimulation has not been investigated. We therefore aimed to assess the short-term efficacy of PTNS against sham electrical stimulation in adults with faecal incontinence. METHODS: We did a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial (CONtrol of Faecal Incontinence using Distal NeuromodulaTion [CONFIDeNT]) in 17 specialist hospital units in the UK that had the skills to manage patients with faecal incontinence...
October 24, 2015: Lancet
Nitesh Patidar, Varun Mittal, Manoj Kumar, Sanjoy Kumar Sureka, Sohrab Arora, Mohd Sualeh Ansari
BACKGROUND: Non-neurogenic overactive bladder (OAB) is a common problem in children that may affect their quality of life. Various methods of neuromodulation have been reported to treat refractory lower urinary tract dysfunction. Since most of these techniques are invasive, they are less applicable in children. OBJECTIVE: To evaluate the efficacy of transcutaneous PTNS in treatment of OAB in children, in a randomized clinical setting. STUDY DESIGN: This study was single-blinded, prospective, sham controlled randomized trial...
December 2015: Journal of Pediatric Urology
Chiara Zecca, Letizia Panicari, Giulio Disanto, Paolo Maino, Anand Singh, G Alessandro Digesu, Claudio Gobbi
INTRODUCTION AND HYPOTHESIS: Bladder dysfunction is a frequent symptom complex in patients with multiple sclerosis (MS) and often compromises the patient's quality of life. Pharmacotherapy has been poorly studied in the MS population showing contradictory results and reduced compliance owing to intolerable side effects. A new neuromodulation technique known as percutaneous tibial nerve stimulation (PTNS) has shown good efficacy and safety in the treatment of neurogenic and non-neurogenic lower urinary tract symptoms...
April 2016: International Urogynecology Journal
Maged M Ragab, Ahmad M Tawfik, Mohamed Abo El-enen, Mohamed Elnady, Osama M El-Gamal, Mohamed El-Kordy, Tarek Gameel, Mohamed Rasheed
OBJECTIVE: To evaluate the efficacy of intermittent percutaneous tibial nerve stimulation (PTNS) as a treatment modality for patients with refractory interstitial cystitis/bladder pain syndrome (IC/BPS). PATIENTS AND METHODS: Twenty female patients with IC/BPS (mean symptom duration of 4.5 ± 2.4 years) each had a 30-minute session of PTNS per week for 12 successive weeks and the symptoms were assessed before, during, and after the treatment sessions by voiding diary, visual analog scale (VAS) for pain, interstitial cystitis symptom and problem indices (ICSI and ICPI), and global response assessment (GRA) scale...
October 2015: Urology
M A Kiselev, E V Zemlyanaya, O M Ipatova, A Yu Gruzinov, E V Ermakova, A V Zabelin, E I Zhabitskaya, O S Druzhilovskaya, V L Aksenov
Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2Å.
October 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
Oliver Preyer, Wolfgang Umek, Thomas Laml, Vesna Bjelic-Radisic, Boris Gabriel, Martina Mittlboeck, Engelbert Hanzal
OBJECTIVE: We performed a randomised controlled trial of percutaneous tibial nerve stimulation (PTNS) versus tolterodine for treating treatment naïve women with overactive bladder (OAB). STUDY DESIGN: 36 patients with symptoms of OAB were randomised to 3 months of treatment with weekly PTNS or tolterodine (2mg bid p.o.). The primary outcome measure was the difference of micturitions per 24h. The secondary outcome measure was the impact on quality of life (QoL) measured with a visual analogue scale (VAS) between baseline and after 3 months of therapy...
August 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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