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https://www.readbyqxmd.com/read/29775603/genetic-and-extracardiac-anomalies-are-associated-with-inferior-single-ventricle-palliation-outcomes
#1
Bahaaldin Alsoufi, Courtney McCracken, Matthew Oster, Subhadra Shashidharan, Kirk Kanter
BACKGROUND: We aim to examine the effect of genetic syndromes and extracardiac anomalies (GS/EC) on single ventricle (SV) palliation with focus on hospital death, interstage mortality, and progression towards subsequent palliation stages. METHODS: 530 neonates with SV underwent first-stage palliation: Norwood (n=284,53%), shunt (n=173,33%), band (n=73,14%). Outcomes were compared between those with GS/EC (n=121,23%) and without GS/EC (n=409,77%). Regression analyses were adjusted for other risk factors (age, gender, prematurity, weight, SV anomaly, first-stage palliation surgery)...
May 15, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29775543/native-bacterial-communities-and-listeria-monocytogenes-survival-in-soils-collected-from-the-lower-mainland-of-british-columbia-canada
#2
Justin Falardeau, Khalil Walji, Maxime Haure, Karen Fong, Gregory A Taylor, Yussanne Ma, Sean Smukler, Siyun Wang
Soil is an important reservoir for Listeria monocytogenes, a foodborne pathogen implicated in numerous produce-related outbreaks. Our objective was to (i) compare the survival of L. monocytogenes between three soils, (ii) compare the native bacterial communities across these soils, and (iii) investigate relationships between L. monocytogenes survival, native bacterial communities, and soil properties. Listeria spp. populations were monitored on PALCAM agar in three soils inoculated with L. monocytogenes (~5 x 106 CFU/g): conventionally farmed (CS), grassland transitioning to conventionally farmed (TS), and uncultivated grassland (GS)...
May 18, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29775044/effect-of-hydrophobicity-on-nano-bio-interactions-of-zwitterionic-luminescent-gold-nanoparticles-at-the-cellular-level
#3
Shasha Sun, Yingyu Huang, Chen Zhou, Sishan Chen, Mengxiao Yu, Jinbin Liu, Jie Zheng
Fundamental understanding of how the hydrophobicity impacts cellular interactions of engineered nanoparticles is critical to their future success in healthcare. Herein, we report that inserting hydrophobic octanethiol onto the surface of zwitterionic luminescent glutathione coated gold nanoparticles (GS-AuNPs) of 2 nm enhanced their affinity to the cellular membrane and increased cellular uptake kinetics by more than one order of magnitude, rather than inducing the accumulation of the AuNPs in the bilayer core or enhancing their passive diffusion...
May 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29773409/correlation-of-objective-assessment-data-with-general-surgery-resident-in-training-evaluation-reports-and-operative-volumes
#4
Jad M Abdelsattar, Yazan N AlJamal, Raaj K Ruparel, Phillip G Rowse, Stephanie F Heller, David R Farley
OBJECTIVE: Faculty evaluations, ABSITE scores, and operative case volumes often tell little about true resident performance. We developed an objective structured clinical examination called the Surgical X-Games (5 rooms, 15 minutes each, 12-15 tests total, different for each postgraduate [PGY] level). We hypothesized that performance in X-Games will prove more useful in identifying areas of strength or weakness among general surgery (GS) residents than faculty evaluations, ABSITE scores, or operative cases volumes...
May 14, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29773088/lipoprotein-a-as-a-marker-for-predicting-the-presence-and-severity-of-coronary-artery-disease-in-untreated-chinese-patients-undergoing-coronary-angiography
#5
Di Sun, Xi Zhao, Sha Li, Yan Zhang, Na Qiong Wu, Cheng Gang Zhu, Yuan Lin Guo, Ying Gao, Ping Qing, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Low-density lipoprotein cholesterol (LDL-C) has been well known as the risk factor of coronary artery disease (CAD). However, the role of lipoprotein (a) [Lp(a)] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp(a) on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. METHODS: We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772837/conventional-pathology-versus-gene-signatures-for-assessing-luminal-a-and-b-type-breast-cancers-results-of-a-prospective-cohort-study
#6
Julia E C van Steenhoven, Anne Kuijer, Paul J van Diest, Joost M van Gorp, Marieke Straver, Sjoerd G Elias, Jelle Wesseling, Emiel Rutgers, Johanna N H Timmer-Bonte, Peter Nieboer, Tineke J Smilde, Alex Imholz, Charlotte F J M Blanken, Sabine Siesling, Thijs van Dalen
In this study, in estrogen receptor positive (ER+) early stage breast cancer patients who were considered candidates for 70-gene signature (70-GS, "MammaPrint") use, we compared molecular subtyping (MS) based on the previously validated 80-gene signature (80-GS, "BluePrint") versus surrogate pathological subtyping (PS). Between 1 January 2013 and 31 December 2015, 595 clinical intermediate risk ER+ early stage breast cancer patients were enrolled. Hormone receptor (HR) and HER2 receptor status were determined by conventional pathology using immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH)...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29772102/novel-nomograms-for-castration-resistant-prostate-cancer-and-survival-outcome-in-patients-with-de-novo-bone-metastatic-prostate-cancer
#7
Jinge Zhao, Guangxi Sun, Banghua Liao, Xingming Zhang, Cameron M Armstrong, Xiaoxue Yin, Jiandong Liu, Junru Chen, Yaojing Yang, Peng Zhao, Qidun Tang, Zhenghao Wang, Zhibin Chen, Xiong Li, Qiang Wei, Xiang Li, Ni Chen, Allen C Gao, Pengfei Shen, Hao Zeng
OBJECTIVES: To develop nomograms predicting the incidence of castration resistant prostate cancer (CRPC) and overall survival (OS) for de novo metastatic prostate cancer (mPCa). MATERIALS AND METHODS: Data from 449 de novo mPCa patients were retrospectively analyzed. Patients were randomly divided into the training (n=314, 70%) and validation cohort (n=135, 30%). Predictive factors were selected by Cox-proportional model and further used for building predictive models...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29770774/i-v-characteristics-of-graphene-nanoribbon-h-bn-heterojunctions-and-resonant-tunneling
#8
Taiga Wakai, Shoichi Sakamoto, Mitsuyoshi Tomiya
We present the first principle calculations of the electrical properties of graphene sheet/h-BN heterojunction(GS/h-BN) and 11-armchair graphene nanoribbon heterojunction(11-AGNR/h-BN), which were carried out using the density functional theory(DFT) method and the non-equilibrium Green's function(NEGF) technique. Since 11-AGNR belongs to the conductive (3n-1)-family of AGNR, both are metallic nanomaterials with two transverse arrays of h-BN, which is a wide-gap semi-conductor. The two h-BN arrays act as double barriers...
May 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29769592/unsaturation-of-vapour-pressure-inside-leaves-of-two-conifer-species
#9
Lucas A Cernusak, Nerea Ubierna, Michael W Jenkins, Steven R Garrity, Thom Rahn, Heath H Powers, David T Hanson, Sanna Sevanto, Suan Chin Wong, Nate G McDowell, Graham D Farquhar
Stomatal conductance (gs ) impacts both photosynthesis and transpiration, and is therefore fundamental to the global carbon and water cycles, food production, and ecosystem services. Mathematical models provide the primary means of analysing this important leaf gas exchange parameter. A nearly universal assumption in such models is that the vapour pressure inside leaves (ei ) remains saturated under all conditions. The validity of this assumption has not been well tested, because so far ei cannot be measured directly...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768382/transbronchial-drainage-using-endobronchial-ultrasonography-with-guide-sheath-for-lung-abscess-a-case-report
#10
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
RATIONALE: Lung abscess was previously treated surgically, but is now mainly treated with antibiotics and ideally with direct drainage, although postural drainage canalso be used. PATIENT CONCERNS: A chest abnormal shadow was detected in an 82-year-old man and he was referred to our department in November 2017. On chest computed tomography (CT), a low-density mass shadow was present in the left S8 segment. Lung abscess and lung cancer were considered as differential diagnoses, and treatment with sulbactam sodium/ampicillin sodium (SBT/ABPC) was first initiated for lung abscess...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767728/andecaliximab-anti-matrix-metalloproteinase-9-induction-therapy-for-ulcerative-colitis-a-randomised-double-blind-placebo-controlled-phase-2-3-study-in-patients-with-moderate-to-severe-disease
#11
William J Sandborn, Bal R Bhandari, Charles Randall, Ziad H Younes, Tomasz Romanczyk, Yan Xin, Emily Wendt, Hao Chai, Matt McKevitt, Sally Zhao, John S Sundy, Satish Keshav, Silvio Danese
Background and Aims: Matrix metalloproteinase-9 [MMP9] is implicated in the pathogenesis of ulcerative colitis [UC] via disruption of intestinal barrier integrity and function. A phase 2/3 combined trial was designed to examine the efficacy, safety, and pharmacokinetics of the anti-MMP9 antibody, andecaliximab [formerly GS-5745], in patients with moderately to severely active UC. Methods: Patients were randomised [1:1:1] to receive placebo, 150 mg andecaliximab every 2 weeks [Q2W], or 150 mg andecaliximab weekly [QW], via subcutaneous administration...
May 14, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29765381/sequence-of-changes-in-maize-responding-to-soil-water-deficit-and-related-critical-thresholds
#12
Xueyan Ma, Qijin He, Guangsheng Zhou
The sequence of changes in crop responding to soil water deficit and related critical thresholds are essential for better drought damage classification and drought monitoring indicators. This study was aimed to investigate the critical thresholds of maize growth and physiological characteristics responding to changing soil water and to reveal the sequence of changes in maize responding to soil water deficit both in seedling and jointing stages based on 2-year's maize field experiment responding to six initial soil water statuses conducted in 2013 and 2014...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29765181/assessment-of-leg-muscle-activity-using-toe-tapping-in-patients-with-parkinson-s-disease-comparison-of-two-types-of-toe-tapping
#13
Seira Taniguchi, Ferdinand Peper, Tetsuya Shimokawa
[Purpose] This study investigates two types of toe tapping, i.e., "closed," with both feet on the floor, and "open," in which the foot does not touch the ground, and evaluates their usefulness in combination with monitoring of muscle activity during toe tapping. [Subjects and Methods] The study enrolled 11 patients with Parkinson's disease (PD) and 9 controls (Controls). The tibialis anterior (TA) and gastrocnemius (GS) muscle activity during toe tapping was measured using surface electromyography...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29762528/performance-enhanced-activated-carbon-electrodes-for-supercapacitors-combining-both-graphene-modified-current-collectors-and-graphene-conductive-additive
#14
Rubing Wang, Yuting Qian, Weiwei Li, Shoupu Zhu, Fengkui Liu, Yufen Guo, Mingliang Chen, Qi Li, Liwei Liu
Graphene has been widely used in the active material, conductive agent, binder or current collector for supercapacitors, due to its large specific surface area, high conductivity, and electron mobility. However, works simultaneously employing graphene as conductive agent and current collector were rarely reported. Here, we report improved activated carbon (AC) electrodes (AC@G@NiF/G) simultaneously combining chemical vapor deposition (CVD) graphene-modified nickel foams (NiF/Gs) current collectors and high quality few-layer graphene conductive additive instead of carbon black (CB)...
May 15, 2018: Materials
https://www.readbyqxmd.com/read/29760914/gas-stunning-with-co-2-affected-meat-color-lipid-peroxidation-oxidative-stress-and-gene-expression-of-mitogen-activated-protein-kinases-glutathione-s-transferases-and-cu-zn-superoxide-dismutase-in-the-skeletal-muscles-of-broilers
#15
Lei Xu, Haijun Zhang, Hongyuan Yue, Shugeng Wu, Haiming Yang, Zhiyue Wang, Guanghai Qi
Background: Meat color and lipid peroxidation are important traits related to meat quality. CO2 concentration is a critical factor that can affect meat quality in the commercial use of gas stunning (GS). However, the effect and mechanism of CO2 stunning on meat color and lipid peroxidation during long-term storage remain poorly studied. We aimed to study the effects of GS methods, especially CO2 concentration, on meat color and meat lipid peroxidation in broilers during long-term storage at 4 °C and to explore the potential mechanism of meat color change via lipid peroxidation and the inner lipid peroxide scavenging system...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29758220/evaluation-of-an-aggressive-prostate-biopsy-strategy-in-men-younger-than-50-years-of-age
#16
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Christopher J D Wallis, Ants Toi, Rashid Sayyid, Bimal Bhindi, Michael Nesbitt, Andrew Evans, Theo van der Kwast, Joan Sweet, Nathan Perlis, Robert J Hamilton, Girish S Kulkarni, Antonio Finelli, Alexandre Zlotta, Neil Fleshner
INTRODUCTION: Longitudinal cohort studies and guidelines demonstrate that PSA ≥1 ng/mL in younger patients confer an increased risk of delayed prostate cancer (PC) death. In our institution we have used an aggressive biopsy strategy among younger patients with PSA of>1 ng/ml. Our objective was to determine the proportion of detected cancer and specifically, clinical significant cancer, with this strategy. METHODS: The prostate biopsy (PB) database at Princess Margaret Cancer Centre was queried for patients younger than 50 who underwent a first PB between 2000 and 2016...
May 11, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29757863/efficacy-using-a-modified-technique-for-tissue-stabilized-guided-subcision-for-the-treatment-of-mild-to-moderate-cellulite-of-the-buttocks-and-thighs
#17
Omer Ibrahim, Adele Haimovic, Nicole Lee, Michael S Kaminer
BACKGROUND: Cellulite can be significantly improved using vacuum-assisted tissue stabilized-guided subcision (TS-GS). However, the treatment of shallow and linear cellulite has remained problematic. OBJECTIVE: In this retrospective study, we describe a modified technique of vacuum-assisted TS-GS. The aim is to demonstrate that this new limited-release technique is an effective treatment for long ripples and interconnected shallow dimples, which are characteristic of mild-to-moderate cellulite...
May 2, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29757153/facile-fabrication-of-3d-porous-mno-gs-cnt-architecture-as-advanced-anode-materials-for-high-performance-lithium-ion-battery
#18
Junyong Wang, Qinglin Deng, Mengjiao Li, Cong Wu, Kai Jiang, Zhigao Hu, Junhao Chu
To overcome inferior rate capability and cycle stability of MnO-based anode materials for lithium-ion batteries (LIBs), we reported a novel 3D porous MnO@GS/CNT composite, consisting of MnO nanoparticles homogeneously distributed on the conductive interconnected framework based on 2D graphene sheets (GS) and 1D carbon nanotubes (CNT). The distinctive architecture offers highly interpenetrated network along with efficient porous channels for fast electron transfer and ionic diffusion as well as abundant stress buffer space to accommodate the volume expansion of the MnO nanoparticles...
May 14, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29756595/96-weeks-treatment-of-tenofovir-alafenamide-vs-tenofovir-disoproxil-fumarate-for-hepatitis-b-virus-infection
#19
Kosh Agarwal, Maurizia Brunetto, Wai Kay Seto, Young-Suk Lim, Scott Fung, Patrick Marcellin, Sang Hoon Ahn, Namiki Izumi, Wan-Long Chuang, Ho Bae, Manoj Sharma, Harry L A Janssen, Calvin Q Pan, Mustafa Kemal Çelen, Norihiro Furusyo, Dr Shalimar, Ki Tae Yoon, Huy Trinh, John F Flaherty, Anuj Gaggar, Audrey H Lau, Andrea L Cathcart, Lanjia Lin, Neeru Bhardwaj, Vithika Suri, G Mani Subramanian, Edward J Gane, Maria Buti, Henry L Y Chan
BACKGROUND & AIMS: Tenofovir alafenamide (TAF) is a new prodrug of tenofovir developed to treat patients with chronic hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF) through more efficient delivery of tenofovir to hepatocytes. In 48-week results from two ongoing, double-blind, randomized phase III trials, TAF was non-inferior to TDF in efficacy with improved renal and bone safety. We report 96-week outcomes for both trials. METHODS: In two international trials, patients with chronic HBV infection were randomized 2:1 to receive 25 mg TAF or 300 mg TDF in a double-blinded fashion...
April 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29756456/no-time-to-delay-fiebig-stages-and-referral-in-acute-hiv-infection-seattle-primary-infection-program-experience
#20
Joanne Stekler, Kenneth Tapia, Janine Maenza, Claire E Stevens, George Ure, Joshua O'Neal, Aric Lane, James I Mullins, Robert Coombs, Sarah E Holte, Ann Cornwall Collier
INTRODUCTION: There has been increasing recognition of the importance of diagnosing individuals during the earliest stages of HIV infection. MATERIALS AND METHODS: Sera from individuals referred to a primary HIV infection research program were screened using the IgG-sensitive Vironostika HIV-1 Microelisa System, IgG/IgM-sensitive GS HIV-1/HIV-2 Plus O antibody EIA, or Abbott ARCHITECT HIV Ag/Ab Combo assay and confirmed by the Bio-Rad Multispot and Western Blot...
May 14, 2018: AIDS Research and Human Retroviruses
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