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https://www.readbyqxmd.com/read/28436625/-effects-of-crocin-on-hippocampus-rapid-kindling-epilepsy-in-mice
#1
Xiting Wang, Oufeng Tang, Yilu Ye, Mingzhi Zheng, Jue Hu, Zhong Chen, Kai Zhong
Objective: To investigate the effect of crocin on the progression and generalized seizure of temporal lobe epilepsy in mice. Methods: Hippocampus rapid kindling model was established in C57BL/6J mice. The effects of crocin on seizure stage, afterdischarge duration (ADD), number of stimulation in each stage and final state, the incidence of generalized seizure (GS), average seizure stage and ADD were observed. Results: Crocin (20 mg/kg) significantly retarded behavioral seizure stages ( P<0.05) and shortened cumulative ADD ( P<0...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28434670/real-time-eutrophication-status-evaluation-of-coastal-waters-using-support-vector-machine-with-grid-search-algorithm
#2
Xianyu Kong, Yuyan Sun, Rongguo Su, Xiaoyong Shi
The development of techniques for real-time monitoring of the eutrophication status of coastal waters is of great importance for realizing potential cost savings in coastal monitoring programs and providing timely advice for marine health management. In this study, a GS optimized SVM was proposed to model relationships between 6 easily measured parameters (DO, Chl-a, C1, C2, C3 and C4) and the TRIX index for rapidly assessing marine eutrophication states of coastal waters. The good predictive performance of the developed method was indicated by the R(2) between the measured and predicted values (0...
April 20, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28433853/addition-of-an-extract-of-lucerne-medicago-sativa-l-to-cattle-diets-effects-on-fatty-acid-profile-meat-quality-and-eating-quality-of-the-m-longissimus-muscle
#3
Siân B MacKintosh, Ian Richardson, Eun Joong Kim, Dirk Dannenberger, Didier Coulmier, Nigel D Scollan
There is considerable interest in enhancing beneficial fatty acids, particularly 18:3n-3, conjugated linoleic acid and long chain n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in beef to provide benefits to human health. Here, the potential to enhance these fatty acids by feeding a n-3 polyunsaturated fatty acid (PUFA)-rich plant extract (PX) from lucerne is presented. Cattle (n=8/diet) were assigned to the following finishing diets: straw and concentrate (S-CC); straw and concentrate containing 25% PX and 2000IUvitaminE/kg PX-concentrate (S-PXC); grass silage (GS); GS plus 75gPX/kg dry matter intake (DMI) (GS-LPX) or GS plus 150g PX/kg DMI (GS-HPX)...
April 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28432503/high-voltage-zones-within-the-pulmonary-vein-antra-major-determinants-of-acute-pulmonary-vein-reconnections-after-atrial-fibrillation-ablation
#4
Koichi Nagashima, Ichiro Watanabe, Yasuo Okumura, Kazuki Iso, Keiko Takahashi, Ryuta Watanabe, Masaru Arai, Sayaka Kurokawa, Toshiko Nakai, Kimie Ohkubo, Shunichi Yoda, Atsushi Hirayama
PURPOSE: Recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) is mainly due to PV reconnections. Patient-specific tissue characteristics that may contribute remain unidentified. This study aimed to assess the relationship between the bipolar electrogram voltage amplitudes recorded from the PV-left atrial (LA) junction and acute PV reconnection sites. METHODS: Three-dimensional LA voltage maps created before an extensive encircling PVI in 47 AF patients (31 men; mean age 62 ± 11 years) were examined for an association between the EGM voltage amplitude recorded from the PV-LA junction and acute post-PVI PV reconnections (spontaneous PV reconnections and/or ATP-provoked dormant PV conduction)...
April 21, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28432097/diazotrophy-overcomes-the-deleterious-growth-phenotype-of-glne-deletion-in-azotobacter-vinelandii
#5
Florence Mus, Alex Tseng, Ray Dixon, John W Peters
Overcoming the inhibitory effects of excess environmental ammonium on nitrogenase synthesis or activity, or preventing ammonium assimilation, have both been considered as strategies to increase the amount of fixed nitrogen transferred from bacterial to plant partners in associative or symbiotic plant-diazotroph relationships. The GlnE adenylyltransferase/adenylyl-removing enzyme catalyzes reversible adenylylation of glutamine synthetase (GS), thereby affecting the post translational regulation of ammonium assimilation critical for appropriate coordination of carbon and nitrogen assimilation...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28432081/glucose-tolerance-and-insulin-responsiveness-in-gitelman-syndrome-patients
#6
Tao Yuan, Lanping Jiang, Chen Chen, Xiaoyan Peng, Min Nie, Xuemei Li, Xiaoping Xing, Xuewang Li, Limeng Chen
Objective Impaired glucose metabolism and insulin sensitivity have been reported in patients with Gitelman syndrome (GS), but insulin secretion and the related mechanisms are not well understood. Design and Methods The serum glucose levels, insulin secretion and insulin sensitivity were evaluated in patients with GS (n=28), patients with type 2 diabetes mellitus (DM) and healthy individuals (n=20 in both groups) using an oral glucose tolerance test. Serum and urine sodium, potassium and creatinine levels were measured at 0, 30, 60, 120 and 180 min after an oral glucose load was administered...
April 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28431182/joint-positions-matter-for-ultrasound-examination-of-ra-patients-increased-power-doppler-signal-in-neutral-versus-flat-position-of-hands
#7
Rusmir Husic, Angelika Lackner, Martin H Stradner, Josef Hermann, Christian Dejaco
Objective.: Position of joints might influence the result of US examination in patients with RA. The purpose of this work was to compare grey-scale (GS) and power Doppler (PWD) findings obtained in neutral vs flat position of hands. Methods.: A cross-sectional study of 42 RA patients with active disease. Two dimensional and 3D sonography of wrists and MCP joints were conducted in two different joint positions: neutral position, which is a slight flexion of the fingers with relaxed extensor muscles; and flat position, where all palm and volar sides of fingers touch the Table...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28431091/suppression-of-oral-sweet-taste-sensation-with-gymnema-sylvestre-affects-postprandial-gastrointestinal-blood-flow-and-gastric-emptying-in-humans
#8
Hideaki Kashima, Kohei Eguchi, Kanae Miyamoto, Masaki Fujimoto, Masako Yamaoka Endo, Nami Aso-Someya, Toshio Kobayashi, Naoyuki Hayashi, Yoshiyuki Fukuba
An oral sweet taste sensation (OSTS) exaggerates digestive activation transiently, but whether it has a role after swallowing a meal is not known. Gymnema sylvestre (GS) can inhibit the OSTS in humans. We explored the effect of the OSTS of glucose intake on gastrointestinal blood flow, gastric emptying, blood-glucose, and plasma-insulin responses during the postprandial phase. Eight participants ingested 200 g (50 g × 4 times) of 15% glucose solution containing 100 mg of 13C-sodium acetate after rinsing with 25 mL of 2...
May 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28430892/anti-arrhythmic-potential-of-the-late-sodium-current-inhibitor-gs-458967-in-murine-scn5a-1798insd-and-human-scn5a-1795insd-ipsc-derived-cardiomyocytes
#9
Vincent Portero, Simona Casini, Maaike Hoekstra, Arie O Verkerk, Isabella Mengarelli, Luiz Belardinelli, Sridharan Rajamani, Arthur A M Wilde, Connie R Bezzina, Marieke W Veldkamp, Carol Ann Remme
AIM: Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an overlap syndrome model of both gain and loss of sodium channel function, comprising cardiomyocytes derived from both human SCN5A-1795insD+/- induced pluripotent stem cells (hiPSC-CMs) and mice carrying the homologous mutation Scn5a-1798insD+/-...
April 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28429904/effect-of-lutein-supplementation-on-visual-function-in-nonproliferative-diabetic-retinopathy
#10
Ping-Chuan Zhang, Chang-Rui Wu, Zhi-Lun Wang, Li-Yuan Wang, Yue Han, Shu-Liu Sun, Qing-Shan Li, Le Ma
BACKGROUND AND OBJECTIVES: The purpose of this study was to determine whether supplementation with lutein improved visual function in patients with nonproliferative diabetic retinopathy (NPDR). METHODS AND STUDY DESIGN: In this randomized, double-blind, placebo-controlled trial, 31 patients with NPDR were assigned randomly to 10 mg/d of lutein or identical placebo for 36 weeks. Visual performance indices, including visual acuity (VA), contrast sensitivity (CS) and glare sensitivity (GS) at four different spatial frequencies, were measured at baseline, week 18 and 36...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429474/the-influence-of-glu-1-and-glu-3-loci-on-dough-rheology-and-bread-making-properties-in-wheat-t-aestivum-l-doubled-haploid-lines
#11
Monika Langner, Karolina Krystkowiak, Bolesław P Salmanowicz, Tadeusz Adamski, Paweł Krajewski, Zygmunt Kaczmarek, Maria Surma
BACKGROUND: The major determinants of wheat quality are Glu-1 and Glu-3 glutenin loci and environmental factors. Additive effects of alleles at Glu-1 and Glu-3 loci, and their interactions were evaluated for dough rheology and baking properties in four groups of wheat doubled haploid lines differing in HMW-GS and LMW-GS composition. RESULTS: Flour quality, Reomixer, dough extension, Farinograph and baking parameters were determined. Groups of lines with the alleles Glu-A3b and Glu-B3d were characterized by higher values of dough and baking parameters than those with the Glu-A3e and Glu-B3a alleles...
April 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28429471/formation-of-silver-nanoparticles-by-electron-transfer-in-peptides-and-c-cytochromes
#12
Serhii I Vasylevskyi, Sonja Kracht, Paula Corcosa, Katharina M Fromm, Bernd Giese, Michael Füeg
The reduction of Ag(+) ions to Ag(0) atoms is a highly endergonic reaction step, only the aggregation to Agn clusters leads to an exergonic process. These elementary chemical reactions play a decisive role if Ag nanoparticles (AgNPs) are generated by electron transfer (ET) reactions to Ag(+) ions. We studied the formation of AgNPs in peptides by photoinduced ET, and in c-cytochromes by ET from their Fe(2+) /hemes. Our earlier photoinduced experiments in peptides had demonstrated that histidine prevents AgNP formation...
April 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28428629/the-role-of-glutamine-synthetase-isozymes-in-enhancing-nitrogen-use-efficiency-of-n-efficient-winter-wheat
#13
Zhiyong Zhang, Shuping Xiong, Yihao Wei, Xiaodan Meng, Xiaochun Wang, Xinming Ma
Glutamine synthetase (GS) isozymes play critical roles in nitrogen (N) metabolism. However, the exact relationship between GS and nitrogen use efficiency (NUE) remain unclear. We have selected and compared two wheat cultivars, YM49 and XN509, which were identified as the N-efficient and N-inefficient genotypes, respectively. In this study, agronomical, morphological, physiological and biochemical approaches were performed. The results showed that TaGS1 was high expressed post-anthesis, and TaGS2 was highly expressed pre-anthesis in N-efficient genotype compared to N-inefficient genotype...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426733/mini-g-proteins-novel-tools-for-studying-gpcrs-in-their-active-conformation
#14
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G proteins, and their ease of expression and purification, they are ideal for biophysical studies of GPCRs in their fully active state. The first mini-G protein developed was mini-Gs. Here we extend the family of mini-G proteins to include mini-Golf, mini-Gi1, mini-Go1 and the chimeras mini-Gs/q and mini-Gs/i...
2017: PloS One
https://www.readbyqxmd.com/read/28426195/one-step-fabrication-of-non-fluorinated-transparent-super-repellent-surfaces-with-tunable-wettability-functioning-both-in-air-and-oil
#15
Mengying Long, Shan Peng, Xiaojun Yang, Wanshun Deng, Ni Wen, Kai Miao, Gongyun Chen, Xinrui Miao, Wenli Deng
In this paper, we have developed a one-step thermal treatment of polydimethylsiloxane (PDMS) liquid to create transparent super-repellent surface (TSS) and super-repellent powder. They are super-repellent toward water and ethylene glycol. During the one-step thermal treatment, PDMS soot generated and deposited onto glass slide (GS) surface to fabricate the TSS without fluorosilane modification. The facilely obtained TSS presented superhydrophobicity and self-cleaning property when immersed into very low-surface-tension oils such as petroleum ether, hexadecane, peanut oil, and dodecane...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28423871/behavioral-characteristics-of-hanwoo-bos-taurus-coreanae-steers-at-different-growth-stages-and-seasons
#16
Na Yeon Kim, Seong Jin Kim, Se Young Jang, Mi Rae Oh, Yu Jiao Tang, Hye Jin Seong, Yeong Sik Yun, Sang Ho Moon
The purpose of this research was to analyze behavioral characteristics of Hanwoo (Bos taurus coreanae) steers for each season and growth stage to enable measurement of animal welfare level for precision livestock farming. A hundred-eight beef steers were divided into three equal groups at a Hanwoo farm according to their growth stage: growing stage (GS), 8months; early-fattening stage (EFS), 19months; and late-fattening stage (LFS), 30months. Twelve behavioral categories were continuously recorded for 13day-time hours in each four seasons with three replications...
April 19, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28423346/endobronchial-ultrasound-transbronchial-biopsy-with-guide-sheath-for-the-diagnosis-of-solitary-pulmonary-nodules
#17
Chun-Hua Xu, Qi Yuan, Li-Ke Yu, Wei Wang, Yong Lin
The aim of this study was to assess the usefulness of endobronchial ultrasound transbronchial biopsy with guide-sheath (EBUS-GS-TBB) for the diagnosis of solitary pulmonary nodules (SPNs). One hundred and eighty patients, who were diagnosed with SPNs and underwent an endobronchial ultrasound procedure. The diagnostic yield, safety and the associated factors were analyzed. Mean EBUS-GS procedure time was 14±8 min. The average number of biopsy specimens obtained in each SPNs was 5±1.2. One hundred and thirty-four SPNs were diagnosed by EBUS-GS-TBB and the diagnostic rate was 74...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422858/350-560%C3%A2-%C3%AE-m-gelatin-sponge-particles-combined-with-transcatheter-arterial-chemoembolization-for-the-treatment-of-elderly-hepatocellular-carcinoma-the-safety-and-efficacy
#18
Guang Sheng Zhao, Chuang Li, Ying Liu, Zhi Zhong Ren, Xiao Lin Yuan, Jun Zhou, Yue Wei Zhang, Ming Zhang
To retrospectively analyze the safety and efficacy of 350-560 μm gelatin sponge particles combined with single-chemotherapy drug transcatheter arterial chemoembolization (Gs-TACE) for the treatment of elderly hepatocellular carcinoma without surgical resection.Thirty elderly hepatocellular carcinoma patients without surgical resection, who received Gs-TACE in our hospital, were selected. Slowly injected gelatin sponge particles (350-560 μm)+ 10 mg lobaplatin injection into the regional embolization tumor target vessel...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421422/hepatitis-c-virus-genotype-3-update-on-current-and-emergent-therapeutic-interventions
#19
REVIEW
Steven W Johnson, Dorothea K Thompson, Brianne Raccor
PURPOSE OF REVIEW: Direct-acting antiviral agents (DAAs) have markedly improved the prognosis of hepatitis C virus (HCV)-genotype 3 (GT3), a highly prevalent infection worldwide. However, in patients with hepatic fibrosis, cirrhosis, or hepatocellular carcinoma (HCC), GT3 infection presents a treatment challenge compared with other genotypes. The dependence of the HCV life cycle on host lipid metabolism suggests the possible utility of targeting host cellular factors for combination anti-HCV therapy...
June 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28421151/extramedullary-relapse-in-a-cml-patient-after-allogeneic-stem-cell-transplantation
#20
Asu Fergun Yilmaz, Nur Soyer, Nazan Ozsan, Seckin Cagirgan, Ajda Gunes, Melda Comert, Fahri Sahin, Guray Saydam, Nur Selvi Gunel, Filiz Vural
Myeloid or granulocytic sarcoma (GS) is a tumoral lesion consisting of immature granulocytic cells. It is a rare entity during the course of CML patients especially after allogeneic stem cell transplantation (SCT). Relapse without bone marrow involvement is much rarer. We report a case of CML patient who relapsed with isolated granulocytic sarcoma after allogeneic SCT during cytogenetic and molecular remission. 28-year-old male was diagnosed as CML and allogeneic SCT was performed because of refractory disease to tyrosine kinase inhibitors...
2017: Case Reports in Hematology
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